Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine.
pmid: 15879096
abstract: Cyclosporine is an immunosuppressive drug that is widely used to prevent organ transplant rejection. Known intracellular ligands for cyclosporine include the cyclophilins, a large family of phylogenetically conserved proteins that potentially regulate protein folding in cells. Immunosuppression by cyclosporine is thought to result from the formation of a drug-cyclophilin complex that binds to and inhibits calcineurin, a serine/threonine phosphatase that is activated by TCR engagement. Amino acids within the cyclophilins that are critical for binding to cyclosporine have been identified. Most of these residues are highly conserved within the 15 mammalian cyclophilins, suggesting that many are potential targets for the drug. We examined the effects of cyclosporine on immune cells and mice lacking Ppia, the gene encoding the prototypical cyclophilin protein cyclophilin A. TCR-induced proliferation and signal transduction by Ppia(-/-) CD4(+) T cells were resistant to cyclosporine, an effect that was attributable to diminished calcineurin inhibition. Immunosuppressive doses of cyclosporine failed to block the responses of Ppia(-/-) mice to allogeneic challenge. Rag2(-/-) mice reconstituted with Ppia(-/-) splenocytes were also cyclosporine resistant, indicating that this property is intrinsic to Ppia(-/-) immune cells. Thus, among multiple potential ligands, CypA is the primary mediator of immunosuppression by cyclosporine.
has PII: 174/10/6030
doi: 10.4049/jimmunol.174.10.6030
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Colgan J
      type: Person
      first name: John
      last name: Colgan
      member of: Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
  slot:
    index: 2
    item: Asmal M
      type: Person
      first name: Mohammed
      last name: Asmal
  slot:
    index: 3
    item: Yu B
      type: Person
      first name: Bin
      last name: Yu
  slot:
    index: 4
    item: Luban J
      type: Person
      first name: Jeremy
      last name: Luban
created: 2005-5-10T09:00
date last updated: 2025-03-09
issued: 2005-05-15
dp: 2005 May 15
ISSN: 0022-1767
has issn l: 0022-1767
issue: 10
has NLM journal title abbreviation: J Immunol
publication name: Journal of immunology (Baltimore, Md. : 1950)
language: eng
has national library of medicine journal id: 2985117R
derived from: NLM
starting page: 6030
ending page: 8
has place of publication: United States
has primary subject term: D021984Q000172Q000235Q000502
has primary subject term: D016572Q000008Q000494
has primary subject term: D004351Q000235Q000276
has primary subject term: D007166Q000008Q000494
has subject term: D000818
has subject term: D019703Q000502
has subject term: D065095
has subject term: D045744
has subject term: D049109Q000187
has subject term: D002478
has subject term: D020868Q000187Q000276
has subject term: D007111Q000187Q000235
has subject term: D020935Q000187Q000276
has subject term: D051379
has subject term: D008807
has subject term: D018345
has subject term: D012513Q000201Q000235Q000276
has subject term: D013154Q000166Q000276Q000637
has subject term: D013601Q000187Q000201Q000378
source: J Immunol. 2005-05-15;174(10):6030-8.
volume: 174

Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.
pmid: 19258500
abstract: Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified and highly expressed in lobular carcinomas of the breast. In this report, we evaluated the biological activity of FGFR1 in a wide range of in vitro assays. Conditional activation of FGFR1 in the nontransformed MCF10A human mammary cell line, MCF10A, resulted in cellular transformation marked by epidermal growth factor-independent cell growth, anchorage-independent cell proliferation and survival, loss of cell polarity, and epithelial-to-mesenchymal transition. Interestingly, small-molecule or small interfering RNA inhibition of ribosomal S6 kinase (RSK) activity induced death of the FGFR1-transformed cells, but not of the parental MCF10A cell line. The dependence of FGFR1-transformed cells on RSK activity was further confirmed in cell lines derived from mouse and human lobular carcinomas that possess high FGFR1 activity. Taken together, these results show the transforming activity of FGFR1 in mammary epithelial cells and identify RSK as a critical component of FGFR1 signaling in lobular carcinomas, thus implicating RSK as a candidate therapeutic target in FGFR1-expressing tumors.
has PII: 0008-5472.CAN-08-3398
doi: 10.1158/0008-5472.CAN-08-3398
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Xian W
      type: Person
      first name: Wa
      last name: Xian
      member of: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 2
    item: Pappas L
      type: Person
      first name: Leontios
      last name: Pappas
  slot:
    index: 3
    item: Pandya D
      type: Person
      first name: Darshan
      last name: Pandya
  slot:
    index: 4
    item: Selfors LM
      type: Person
      first name: Laura M
      last name: Selfors
  slot:
    index: 5
    item: Derksen PW
      type: Person
      first name: Patrick W
      last name: Derksen
  slot:
    index: 6
    item: de Bruin M
      type: Person
      first name: Michiel
      last name: de Bruin
  slot:
    index: 7
    item: Gray NS
      type: Person
      first name: Nathanael S
      last name: Gray
  slot:
    index: 8
    item: Jonkers J
      type: Person
      first name: Jos
      last name: Jonkers
  slot:
    index: 9
    item: Rosen JM
      type: Person
      first name: Jeffrey M
      last name: Rosen
  slot:
    index: 10
    item: Brugge JS
      type: Person
      first name: Joan S
      last name: Brugge
created: 2009-3-5T09:00
date last updated: 2025-03-09
issued: 2009-03-15
dp: 2009 Mar 15
e ISSN: 1538-7445
has issn l: 0008-5472
issue: 6
has NLM journal title abbreviation: Cancer Res
publication name: Cancer research
language: eng
has national library of medicine journal id: 2984705R
derived from: NLM
starting page: 2244
ending page: 51
has place of publication: United States
has primary subject term: D001943Q000235Q000378Q000473
has primary subject term: D002471Q000235Q000378Q000473
has primary subject term: D042361Q000201Q000378Q000473
has primary subject term: D051496Q000096Q000235Q000378
has primary subject term: D038744Q000037Q000378
has subject term: D000818
has subject term: D018275Q000201Q000235Q000378Q000473
has subject term: D048708Q000502
has subject term: D045744
has subject term: D002470Q000502
has subject term: D004847Q000378Q000473
has subject term: D006801
has subject term: D008325Q000235Q000378Q000473
has subject term: D051379
has subject term: D015398
source: Cancer Res. 2009-03-15;69(6):2244-51.
volume: 69

Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use.
pmid: 23289664
abstract: Inadequate tissue perfusion is a key contributor to early complications following reconstructive procedures. Accurate and reliable intraoperative evaluation of tissue perfusion is critical to reduce complications and improve clinical outcomes. Clinical judgment is the most commonly used method for evaluating blood supply, but when used alone, is not always completely reliable. A variety of other methodologies have been evaluated, including Doppler devices, tissue oximetry, and fluorescein, among others. However, none have achieved widespread acceptance. Recently, intraoperative laser angiography using indocyanine green was introduced to reconstructive surgery. This vascular imaging technology provides real-time assessment of tissue perfusion that correlates with clinical outcomes and can be used to guide surgical decision making. Although this technology has been used for decades in other areas, surgeons may not be aware of its utility for perfusion assessment in reconstructive surgery. A group of experts with extensive experience with intraoperative laser angiography convened to identify key issues in perfusion assessment, review available methodologies, and produce initial recommendations for the use of this technology in reconstructive procedures.
has PII: 1750-1164-7-1
doi: 10.1186/1750-1164-7-1
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Gurtner GC
      type: Person
      first name: Geoffrey C
      last name: Gurtner
      member of: Plastic and Reconstructive Surgery, Duke University Medical Center, Durham, NC, USA. michael.zenn@duke.edu.
  slot:
    index: 2
    item: Jones GE
      type: Person
      first name: Glyn E
      last name: Jones
  slot:
    index: 3
    item: Neligan PC
      type: Person
      first name: Peter C
      last name: Neligan
  slot:
    index: 4
    item: Newman MI
      type: Person
      first name: Martin I
      last name: Newman
  slot:
    index: 5
    item: Phillips BT
      type: Person
      first name: Brett T
      last name: Phillips
  slot:
    index: 6
    item: Sacks JM
      type: Person
      first name: Justin M
      last name: Sacks
  slot:
    index: 7
    item: Zenn MR
      type: Person
      first name: Michael R
      last name: Zenn
created: 2013-1-8T06:00
date last updated: 2025-03-09
issued: 2013-01-07
dp: 2013 Jan 07
ISSN: 1750-1164
has issn l: 1750-1164
issue: 1
has NLM journal title abbreviation: Ann Surg Innov Res
publication name: Annals of surgical innovation and research
language: eng
has national library of medicine journal id: 101266580
derived from: NLM
pg: 1
has place of publication: England
source: Ann Surg Innov Res. 2013-01-07;7(1):1.
volume: 7

Using multiple methods to characterize the phenotype of individuals with a family history of major depressive disorder.
pmid: 23764382
abstract: Unaffected relatives (URs) of individuals with major depressive disorder (MDD) are biologically more vulnerable to depression. We compare healthy URs and controls at the level of phenotype (symptoms and functioning) and endophenotype (negative emotion bias), and further investigate the interrelation between these and the contribution of environmental early life stress.URs (n=101), identified using Family History Screen interview methods and matched controls completed written and interview questions assessing symptoms of depression and anxiety, negative cognitive style, life functioning and early life stress. Biases in emotion processing were measured using a facial expression of emotion identification paradigm.Compared to controls, URs reported higher levels of depression and anxiety, a stronger negative cognitive bias, and poorer functioning and lower satisfaction with life. URs were slower to correctly identify fear and sad facial expressions. A slower response time to identify sad faces was correlated with lower quality of life in the social domain. Early life stress (ELS) did not contribute significantly to any outcome.The methodology relies on accurate reporting of participants' own psychiatric history and that of their family members. The degree of vulnerability varies among URs.A family history of depression accounts for subtle differences in symptom levels and functioning without a necessary role of ELS. A negative emotion bias in processing emotion may be one vulnerability marker for MDD. Biological markers may affect functioning measures before symptoms at the level of experience.
rights: Copyright © 2013 Elsevier B.V. All rights reserved.
has PII: S0165-0327(13)00343-1
doi: 10.1016/j.jad.2013.04.042
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Watters AJ
      type: Person
      first name: Anna J
      last name: Watters
      member of: Discipline of Psychiatry, University of Sydney Medical School, NSW, Australia.
  slot:
    index: 2
    item: Gotlib IH
      type: Person
      first name: Ian H
      last name: Gotlib
  slot:
    index: 3
    item: Harris AW
      type: Person
      first name: Anthony W F
      last name: Harris
  slot:
    index: 4
    item: Boyce PM
      type: Person
      first name: Philip M
      last name: Boyce
  slot:
    index: 5
    item: Williams LM
      type: Person
      first name: Leanne M
      last name: Williams
created: 2013-6-15T06:00
date last updated: 2025-03-09
issued: 2013-09-05
dp: 2013 Sep 05
e ISSN: 1573-2517
has issn l: 0165-0327
issue: 2
has NLM journal title abbreviation: J Affect Disord
publication name: Journal of affective disorders
language: eng
has national library of medicine journal id: 7906073
derived from: NLM
starting page: 474
ending page: 80
has place of publication: Netherlands
has primary subject term: D003865Q000235Q000523
has primary subject term: D004644
has primary subject term: D010641
has subject term: D000293
has subject term: D000328
has subject term: D015982
has subject term: D016022
has subject term: D003071
has subject term: D003863
has subject term: D005239
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D013315
has subject term: D055815
source: J Affect Disord. 2013-09-05;150(2):474-80.
volume: 150

Melancholia in later life: late and early onset differences in presentation, course, and dementia risk.
pmid: 24677247
abstract: Depression is a risk factor for cognitive decline and dementia. This risk may vary with age of onset and depression subtype. Late onset depression (LOD, 60 years and older) is associated with more cognitive decline, whereas early onset depression (EOD, before 60 years) is associated with more residual depressive symptoms. Potential differences may reflect divergent etiologies. These onset differences, however, have not been examined in the melancholic subtype of depression in older adults.Data were obtained from the Neurocognitive Outcomes of Depression in the Elderly study. Participants (N = 284, 73% EOD-melancholic (EOD-M) and 27% LOD-melancholic (LOD-M)) were followed up over 3 years. Factor analyses examined differences in baseline depressive symptoms. Hierarchical linear growth curve models examined changes in depressive symptoms (Montgomery-Asberg Depression Rating Scale) and cognition (mini mental state examination). An annual clinical review panel assigned diagnoses of dementia.The LOD-M participants had more vegetative symptoms at baseline. LOD-M exhibited greater cognitive decline but fewer residual depressive symptoms than EOD-M. Among participants who remained in the study for at least 1 year, in uncontrolled analyses, a greater percentage of LOD-M compared with EOD-M developed dementia (23.0% vs. 7.8%). Whereas in logistic analyses, controlling for baseline demographics, age at onset remained a predictor of dementia, the odds ratio suggested that the effect was relatively small.The EOD-M and LOD-M participants have a different presentation and course. LOD-M may represent a syndrome of neuropsychiatric deterioration with expression of both depressive symptoms and cognitive decline.
rights: Copyright © 2014 John Wiley & Sons, Ltd.
doi: 10.1002/gps.4083
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Sachs-Ericsson N
      type: Person
      first name: Natalie
      last name: Sachs-Ericsson
      member of: Department of Psychology, Florida State University, Tallahassee, FL, USA.
  slot:
    index: 2
    item: Moxley JH
      type: Person
      first name: Jerad H
      last name: Moxley
  slot:
    index: 3
    item: Corsentino E
      type: Person
      first name: Elizabeth
      last name: Corsentino
  slot:
    index: 4
    item: Rushing NC
      type: Person
      first name: Nicole Collins
      last name: Rushing
  slot:
    index: 5
    item: Sheffler J
      type: Person
      first name: Julia
      last name: Sheffler
  slot:
    index: 6
    item: Selby EA
      type: Person
      first name: Edward A
      last name: Selby
  slot:
    index: 7
    item: Gotlib I
      type: Person
      first name: Ian
      last name: Gotlib
  slot:
    index: 8
    item: Steffens DC
      type: Person
      first name: David C
      last name: Steffens
created: 2014-3-29T06:00
date last updated: 2025-03-09
issued: 2014-09
dp: 2014 Sep
e ISSN: 1099-1166
has issn l: 0885-6230
issue: 9
has NLM journal title abbreviation: Int J Geriatr Psychiatry
publication name: International journal of geriatric psychiatry
language: eng
has national library of medicine journal id: 8710629
derived from: NLM
starting page: 943
ending page: 51
has place of publication: England
has primary subject term: D003704Q000175Q000523
has primary subject term: D003866Q000175Q000523
has subject term: D000367
has subject term: D017668
has subject term: D000368
has subject term: D000369
has subject term: D003072Q000523
has subject term: D005163
has subject term: D005260
has subject term: D006801
has subject term: D016014
has subject term: D008297
has subject term: D009483
has subject term: D011237
has subject term: D011446
has subject term: D012307
has subject term: D012737
source: Int J Geriatr Psychiatry. 2014-09;29(9):943-51.
volume: 29

Health information technology interventions enhance care completion, engagement in HIV care and treatment, and viral suppression among HIV-infected patients in publicly funded settings.
pmid: 25030033
abstract: The National HIV/AIDS Strategy (NHAS) emphasizes the use of technology to facilitate coordination of comprehensive care for people with HIV. We examined the effect of six health information technology (HIT) interventions in a Ryan White-funded Special Projects of National Significance (SPNS) on care completion services, engagement in HIV care, and viral suppression.Interventions included use of surveillance data to identify out-of-care individuals, extending access to electronic health records to support service providers, use of electronic laboratory ordering and prescribing, and development of a patient portal. Data from a sample of electronic patient records from each site were analyzed to assess changes in utilization of comprehensive care (prevention screening, support service utilization), engagement in primary HIV medical care (receipt of services and use of antiretroviral therapy), and viral suppression. We used weighted generalized estimating equations to estimate outcomes while accounting for the unequal contribution of data and differences in the distribution of patient characteristics across sites and over time.We observed statistically significant changes in the desired direction in comprehensive care utilization and engagement in primary care outcomes targeted by each site. Five of six sites experienced statistically significant increases in viral suppression.These results provide additional support for the use of HIT as a valuable tool for achieving the NHAS goal of providing comprehensive care for all people living with HIV. HIT has the potential to increase utilization of services, improve health outcomes for people with HIV, and reduce community viral load and subsequent transmission of HIV.
rights: © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com For affiliation see end of article.
has PII: amiajnl-2013-002623
doi: 10.1136/amiajnl-2013-002623
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Shade SB
      type: Person
      first name: Starley B
      last name: Shade
      member of: Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, California, USA.
  slot:
    index: 2
    item: Steward WT
      type: Person
      first name: Wayne T
      last name: Steward
      member of: Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, California, USA.
  slot:
    index: 3
    item: Koester KA
      type: Person
      first name: Kimberly A
      last name: Koester
      member of: Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, California, USA.
  slot:
    index: 4
    item: Chakravarty D
      type: Person
      first name: Deepalika
      last name: Chakravarty
      member of: Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, California, USA.
  slot:
    index: 5
    item: Myers JJ
      type: Person
      first name: Janet J
      last name: Myers
      member of: Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, California, USA.
created: 2014-7-18T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e104
ending page: 11
has place of publication: England
has primary subject term: D057286
has primary subject term: D015658Q000628Q000821
has primary subject term: D008490
has primary subject term: D010346
has subject term: D022126
has subject term: D044966Q000627
has subject term: D006801
has subject term: D011159
has subject term: D011314Q000331
has subject term: D011632
has subject term: D012044
has subject term: D014481
has subject term: D019562
source: J Am Med Inform Assoc. 2015-04;22(e1):e104-11.
volume: 22

Towards creating the perfect electronic prescription.
pmid: 25038197
abstract: Significant strides have been made in electronic (e)-prescribing standards and software applications that have further fueled the adoption and use of e-prescribing. However, for e-prescribing to realize its full potential for improving the safety, effectiveness, and efficiency of prescription drug delivery, important work remains to be carried out. This perspective describes the ultimate goal of all e-prescribing stakeholders including prescribers and dispensing pharmacists: a clear, complete, and unambiguous e-prescription order that can be seamlessly received, processed, and fulfilled at the dispensing pharmacy without the need for additional clarification from the prescriber. We discuss the challenges to creating the perfect e-prescription by focusing on selected data segments and data fields that are available in the new e-prescription transaction as defined in the NCPDP SCRIPT Standard and suggest steps that could be taken to move the industry closer to achieving this vision.
rights: © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-002738
doi: 10.1136/amiajnl-2014-002738
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Dhavle AA
      type: Person
      first name: Ajit A
      last name: Dhavle
      member of: Surescripts LLC, Arlington, Virginia, USA.
  slot:
    index: 2
    item: Rupp MT
      type: Person
      first name: Michael T
      last name: Rupp
      member of: Midwestern University, Glendale, Arizona, USA.
created: 2014-7-20T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e7
ending page: e12
has place of publication: England
has primary subject term: D055695Q000592
has primary subject term: D014584
has subject term: D050316Q000592
has subject term: D010594
has subject term: D055553
source: J Am Med Inform Assoc. 2015-04;22(e1):e7-e12.
volume: 22

Assessment of administrative claims data for public health reporting of Salmonella in Tennessee.
pmid: 25053578
abstract: In the USA, approximately 4% of the estimated 1 million Salmonella infections occurring annually are reported to public health. Administrative claims data from large health insurance companies capture disease-specific data which could potentially enhance public health surveillance. To determine the utility of medical claims data for public health reporting of Salmonella, we assessed medical claims data from BlueCross BlueShield of Tennessee (BCBST) members compared to Tennessee Department of Health (TDH) surveillance data. BCBST Salmonella cases diagnosed during 2007-2011 were matched to TDH Salmonella cases reported during the same time period. Matches and non-matches were validated using medical records. Of the 450 BCBST cases identified, 72% matched TDH cases. All culture-confirmed BCBST cases were reported to TDH. Non-matched BCBST cases included clinical diagnoses which were culture negative or not tested. Our findings indicate administrative claims data are not currently a viable mechanism for enhancing routine reporting of Salmonella infections.
rights: © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-002909
doi: 10.1136/amiajnl-2014-002909
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Marder E
      type: Person
      first name: Ellyn
      last name: Marder
      member of: Tennessee Department of Health, Communicable and Environmental Diseases and Emergency Preparedness, Nashville, Tennessee, USA CDC/CSTE Applied Epidemiology, Atlanta, Georgia, USA.
  slot:
    index: 2
    item: Garman K
      type: Person
      first name: Katie
      last name: Garman
      member of: Tennessee Department of Health, Communicable and Environmental Diseases and Emergency Preparedness, Nashville, Tennessee, USA.
  slot:
    index: 3
    item: Jones TF
      type: Person
      first name: Timothy F
      last name: Jones
      member of: Tennessee Department of Health, Communicable and Environmental Diseases and Emergency Preparedness, Nashville, Tennessee, USA.
  slot:
    index: 4
    item: Dunn J
      type: Person
      first name: John
      last name: Dunn
      member of: Tennessee Department of Health, Communicable and Environmental Diseases and Emergency Preparedness, Nashville, Tennessee, USA.
  slot:
    index: 5
    item: Jones S
      type: Person
      first name: Stephen
      last name: Jones
      member of: BlueCross BlueShield of Tennessee, Chattanooga, Tennessee, USA.
created: 2014-7-24T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e34
ending page: 8
has place of publication: England
has primary subject term: D018563
has primary subject term: D007345
has primary subject term: D062486Q000379
has primary subject term: D012480Q000453
has subject term: D000465
has subject term: D006801
has subject term: D015994
has subject term: D007348
has subject term: D013714Q000453
source: J Am Med Inform Assoc. 2015-04;22(e1):e34-8.
volume: 22

The double-edged sword of electronic health records: implications for patient disclosure.
pmid: 25059953
abstract: Electronic health record (EHR) systems are linked to improvements in quality of care, yet also privacy and security risks. Results from research studies are mixed about whether patients withhold personal information from their providers to protect against the perceived EHR privacy and security risks. This study seeks to reconcile the mixed findings by focusing on whether accounting for patients' global ratings of care reveals a relationship between EHR provider-use and patient non-disclosure.A nationally representative sample from the 2012 Health Information National Trends Survey was analyzed using bivariate and multivariable logit regressions to examine whether global ratings of care suppress the relationship between EHR provider-use and patient non-disclosure.13% of respondents reported having ever withheld information from a provider because of privacy/security concerns. Bivariate analysis showed that withholding information was unrelated to whether respondents' providers used an EHR. Multivariable analysis showed that accounting for respondents' global ratings of care revealed a positive relationship between having a provider who uses an EHR and withholding information.After accounting for global ratings of care, findings suggest that patients may non-disclose to providers to protect against the perceived EHR privacy and security risks. Despite evidence that EHRs inhibit patient disclosure, their advantages for promoting quality of care may outweigh the drawbacks.Clinicians should leverage the EHR's value in quality of care and discuss patients' privacy concerns during clinic visits, while policy makers should consider how to address the real and perceived privacy and security risks of EHRs.
rights: © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-002804
doi: 10.1136/amiajnl-2014-002804
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Campos-Castillo C
      type: Person
      first name: Celeste
      last name: Campos-Castillo
      member of: Department of Sociology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
  slot:
    index: 2
    item: Anthony DL
      type: Person
      first name: Denise L
      last name: Anthony
      member of: Department of Sociology, Institute for Security, Technology, and Society, Dartmouth College, Hanover, New Hampshire, USA.
created: 2014-7-26T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e130
ending page: 40
has place of publication: England
has primary subject term: D003219
has primary subject term: D030881
has primary subject term: D057286
has primary subject term: D011787
has subject term: D016494
has subject term: D019538
has subject term: D006801
has subject term: D015999
has subject term: D014481
source: J Am Med Inform Assoc. 2015-04;22(e1):e130-40.
volume: 22

Birth of identity: understanding changes to birth certificates and their value for identity resolution.
pmid: 25080533
abstract: Identity information is often used to link records within or among information systems in public health and clinical settings. The quality and stability of birth certificate identifiers impacts both the success of linkage efforts and the value of birth certificate registries for identity resolution.Our objectives were to describe: (1) the frequency and cause of changes to birth certificate identifiers as children age, and (2) the frequency of events (ie, adoptions, paternities, amendments) that may trigger changes and their impact on names.We obtained two de-identified datasets from the Utah birth certificate registry: (1) change history from 2000 to 2012, and (2) occurrences for adoptions, paternities, and amendments among births in 1987 and 2000. We conducted cohort analyses for births in 1987 and 2000, examining the number, reason, and extent of changes over time. We conducted cross-sectional analyses to assess the patterns of changes between 2000 and 2012.In a cohort of 48 350 individuals born in 2000 in Utah, 3164 (6.5%) experienced a change in identifiers prior to their 13th birthday, with most changes occurring before 2 years of age. Cross-sectional analysis showed that identifiers are stable for individuals over 5 years of age, but patterns of changes fluctuate considerably over time, potentially due to policy and social factors.Identities represented in birth certificates change over time. Specific events that cause changes to birth certificates also fluctuate over time. Understanding these changes can help in the development of automated strategies to improve identity resolution.
rights: © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-002774
doi: 10.1136/amiajnl-2014-002774
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Duncan J
      type: Person
      first name: Jeffrey
      last name: Duncan
      member of: Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA.
  slot:
    index: 2
    item: Narus SP
      type: Person
      first name: Scott P
      last name: Narus
      member of: Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA Intermountain Healthcare, Salt Lake City, Utah, USA.
  slot:
    index: 3
    item: Clyde S
      type: Person
      first name: Stephen
      last name: Clyde
      member of: Department of Computer Science, Utah State University, Logan, Utah, USA.
  slot:
    index: 4
    item: Eilbeck K
      type: Person
      first name: Karen
      last name: Eilbeck
      member of: Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA.
  slot:
    index: 5
    item: Thornton S
      type: Person
      first name: Sidney
      last name: Thornton
      member of: Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA Intermountain Healthcare, Salt Lake City, Utah, USA.
  slot:
    index: 6
    item: Staes C
      type: Person
      first name: Catherine
      last name: Staes
      member of: Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA.
created: 2014-8-1T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e120
ending page: 9
has place of publication: England
has primary subject term: D001719Q000331
has primary subject term: D008498
has subject term: D000293
has subject term: D000300Q000331
has subject term: D002648
has subject term: D002675
has subject term: D015331
has subject term: D003430
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D008297
has subject term: D010334
has subject term: D014589
source: J Am Med Inform Assoc. 2015-04;22(e1):e120-9.
volume: 22

The use of crowdsourcing for dietary self-monitoring: crowdsourced ratings of food pictures are comparable to ratings by trained observers.
pmid: 25092793
abstract: Crowdsourcing dietary ratings for food photographs, which uses the input of several users to provide feedback, has potential to assist with dietary self-monitoring.This study assessed how closely crowdsourced ratings of foods and beverages contained in 450 pictures from the Eatery mobile app as rated by peer users (fellow Eatery app users) (n = 5006 peers, mean 18.4 peer ratings/photo) using a simple 'healthiness' scale were related to the ratings of the same pictures by trained observers (raters). In addition, the foods and beverages present in each picture were categorized and the impact on the peer rating scale by food/beverage category was examined. Raters were trained to provide a 'healthiness' score using criteria from the 2010 US Dietary Guidelines.The average of all three raters' scores was highly correlated with the peer healthiness score for all photos (r = 0.88, p<0.001). Using a multivariate linear model (R(2) = 0.73) to examine the association of peer healthiness scores with foods and beverages present in photos, peer ratings were in the hypothesized direction for both foods/beverages to increase and ones to limit. Photos with fruit, vegetables, whole grains, and legumes, nuts, and seeds (borderline at p = 0.06) were all associated with higher peer healthiness scores, and processed foods (borderline at p = 0.06), food from fast food restaurants, refined grains, red meat, cheese, savory snacks, sweets/desserts, and sugar-sweetened beverages were associated with lower peer healthiness scores.The findings suggest that crowdsourcing holds potential to provide basic feedback on overall diet quality to users utilizing a low burden approach.
rights: © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-002636
doi: 10.1136/amiajnl-2014-002636
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Turner-McGrievy GM
      type: Person
      first name: Gabrielle M
      last name: Turner-McGrievy
      member of: Health Promotion, Education, and Behavior, University of South Carolina, Arnold School of Public Health, Columbia, South Carolina, USA.
  slot:
    index: 2
    item: Helander EE
      type: Person
      first name: Elina E
      last name: Helander
      member of: Department of Signal Processing, Tampere University of Technology, Tampere, Finland.
  slot:
    index: 3
    item: Kaipainen K
      type: Person
      first name: Kirsikka
      last name: Kaipainen
      member of: VTT Technical Research Centre of Finland, Tampere, Finland.
  slot:
    index: 4
    item: Perez-Macias JM
      type: Person
      first name: Jose Maria
      last name: Perez-Macias
      member of: Department of Signal Processing, Tampere University of Technology, Tampere, Finland.
  slot:
    index: 5
    item: Korhonen I
      type: Person
      first name: Ilkka
      last name: Korhonen
      member of: Department of Signal Processing, Tampere University of Technology, Tampere, Finland VTT Technical Research Centre of Finland, Tampere, Finland.
created: 2014-8-6T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e112
ending page: 9
has place of publication: England
has primary subject term: D001628
has primary subject term: D063045
has primary subject term: D004032
has primary subject term: D005502
has primary subject term: D063731
has primary subject term: D010781
has subject term: D006801
has subject term: D016014
has subject term: D012648
source: J Am Med Inform Assoc. 2015-04;22(e1):e112-9.
volume: 22

Availability and quality of mobile health app privacy policies.
pmid: 25147247
abstract: Mobile health (mHealth) customers shopping for applications (apps) should be aware of app privacy practices so they can make informed decisions about purchase and use. We sought to assess the availability, scope, and transparency of mHealth app privacy policies on iOS and Android. Over 35,000 mHealth apps are available for iOS and Android. Of the 600 most commonly used apps, only 183 (30.5%) had privacy policies. Average policy length was 1755 (SD 1301) words with a reading grade level of 16 (SD 2.9). Two thirds (66.1%) of privacy policies did not specifically address the app itself. Our findings show that currently mHealth developers often fail to provide app privacy policies. The privacy policies that are available do not make information privacy practices transparent to users, require college-level literacy, and are often not focused on the app itself. Further research is warranted to address why privacy policies are often absent, opaque, or irrelevant, and to find a remedy.
rights: © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2013-002605
doi: 10.1136/amiajnl-2013-002605
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sunyaev A
      type: Person
      first name: Ali
      last name: Sunyaev
      member of: Faculty of Management, Economics and Social Sciences, University of Cologne, Cologne, Germany.
  slot:
    index: 2
    item: Dehling T
      type: Person
      first name: Tobias
      last name: Dehling
      member of: Faculty of Management, Economics and Social Sciences, University of Cologne, Cologne, Germany.
  slot:
    index: 3
    item: Taylor PL
      type: Person
      first name: Patrick L
      last name: Taylor
      member of: Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, The Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard Law School, Boston, Massachusetts, USA.
  slot:
    index: 4
    item: Mandl KD
      type: Person
      first name: Kenneth D
      last name: Mandl
      member of: Children's Hospital Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
created: 2014-8-26T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
created: 2014-8-23T06:00
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e28
ending page: 33
has place of publication: England
has primary subject term: D063731
has primary subject term: D018907
has primary subject term: D017216
source: J Am Med Inform Assoc. 2015-04;22(e1):e28-33.
volume: 22

Reducing caregiver stress with internet-based interventions: a systematic review of open-label and randomized controlled trials.
pmid: 25125686
abstract: The high level of stress associated with caring for others with medical conditions has been recognized for some time. Reducing caregiver stress can improve caregiver quality of life as well as improve the care they provide to loved ones. This systematic review assesses the effectiveness of internet-based interventions to decrease caregiver stress.A comprehensive literature search of Ovid MEDLINE (1946-2013), Embase (1988-2013), PsycINFO (1987-2013), and CINAHL was conducted using terms related to caregiver and internet-based interventions. Internet-based interventions involving informal caregivers in an open-label or randomized controlled trial setting were included. A pair of raters independently reviewed all published abstracts. Data regarding participants, interventions, and outcomes were extracted and, for randomized trials, methodology quality was also reviewed.Eight open-label trials met the review criteria: three showed positive benefit in reducing caregiver stress, four were partially positive (some outcomes positive, others negative), and one was a negative study. Sixteen randomized trials met the review criteria: six showed positive benefit, five were partially positive, and five were negative. There were no clear patterns as to the variables (such as study duration and complexity of intervention) associated with better outcomes, although earlier studies typically had more negative outcomes.Internet-based interventions were mostly effective in reducing aspects of caregiver stress and improving their well-being. Further studies to assess outcomes for caregivers and their recipients' health, different technology delivery methods, and the cost of such interventions are needed.
rights: © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com For affiliation see end of article.
has PII: amiajnl-2014-002817
doi: 10.1136/amiajnl-2014-002817
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hu C
      type: Person
      first name: Chunling
      last name: Hu
      member of: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 2
    item: Kung S
      type: Person
      first name: Simon
      last name: Kung
      member of: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 3
    item: Rummans TA
      type: Person
      first name: Teresa A
      last name: Rummans
      member of: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 4
    item: Clark MM
      type: Person
      first name: Matthew M
      last name: Clark
      member of: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 5
    item: Lapid MI
      type: Person
      first name: Maria I
      last name: Lapid
      member of: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
created: 2014-8-16T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e194
ending page: 209
has place of publication: England
has primary subject term: D017028Q000523
has primary subject term: D006266Q000379
has primary subject term: D020407
has primary subject term: D013315Q000517
has subject term: D006801
has subject term: D016032
source: J Am Med Inform Assoc. 2015-04;22(e1):e194-209.
volume: 22

Automatic abstraction of imaging observations with their characteristics from mammography reports.
pmid: 25352567
abstract: Radiology reports are usually narrative, unstructured text, a format which hinders the ability to input report contents into decision support systems. In addition, reports often describe multiple lesions, and it is challenging to automatically extract information on each lesion and its relationships to characteristics, anatomic locations, and other information that describes it. The goal of our work is to develop natural language processing (NLP) methods to recognize each lesion in free-text mammography reports and to extract its corresponding relationships, producing a complete information frame for each lesion.We built an NLP information extraction pipeline in the General Architecture for Text Engineering (GATE) NLP toolkit. Sequential processing modules are executed, producing an output information frame required for a mammography decision support system. Each lesion described in the report is identified by linking it with its anatomic location in the breast. In order to evaluate our system, we selected 300 mammography reports from a hospital report database.The gold standard contained 797 lesions, and our system detected 815 lesions (780 true positives, 35 false positives, and 17 false negatives). The precision of detecting all the imaging observations with their modifiers was 94.9, recall was 90.9, and the F measure was 92.8.Our NLP system extracts each imaging observation and its characteristics from mammography reports. Although our application focuses on the domain of mammography, we believe our approach can generalize to other domains and may narrow the gap between unstructured clinical report text and structured information extraction needed for data mining and decision support.
rights: © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-003009
doi: 10.1136/amiajnl-2014-003009
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Bozkurt S
      type: Person
      first name: Selen
      last name: Bozkurt
      member of: Department of Biostatistics and Medical Informatics, Akdeniz University Faculty of Medicine, Antalya, Turkey.
  slot:
    index: 2
    item: Lipson JA
      type: Person
      first name: Jafi A
      last name: Lipson
      member of: Department of Radiology, Stanford University, Stanford, California, USA.
  slot:
    index: 3
    item: Senol U
      type: Person
      first name: Utku
      last name: Senol
      member of: Department of Radiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
  slot:
    index: 4
    item: Rubin DL
      type: Person
      first name: Daniel L
      last name: Rubin
      member of: Department of Radiology, Stanford University, Stanford, California, USA Department of Medicine (Biomedical Informatics Research), Stanford University, Stanford, California, USA.
created: 2014-10-30T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e81
ending page: 92
has place of publication: England
has primary subject term: D016247Q000379
has primary subject term: D008327
has primary subject term: D009323
has primary subject term: D011873
has subject term: D020000
has subject term: D001330
has subject term: D005260
has subject term: D006801
source: J Am Med Inform Assoc. 2015-04;22(e1):e81-92.
volume: 22

Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting.
pmid: 25359545
abstract: In alignment with a major shift toward patient-centered care as the model for improving care in our health system, informatics is transforming patient-provider relationships and overall care delivery. AMIA's 2013 Health Policy Invitational was focused on examining existing challenges surrounding full engagement of the patient and crafting a research agenda and policy framework encouraging the use of informatics solutions to achieve this goal. The group tackled this challenge from educational, technical, and research perspectives. Recommendations include the need for consumer education regarding rights to data access, the need for consumers to access their health information in real time, and further research on effective methods to engage patients. This paper summarizes the meeting as well as the research agenda and policy recommendations prioritized among the invited experts and stakeholders.
rights: © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: amiajnl-2014-003176
doi: 10.1136/amiajnl-2014-003176
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Brennan PF
      type: Person
      first name: Patti Flatley
      last name: Brennan
      member of: University of Wisconsin, Madison, Wisconsin, USA.
  slot:
    index: 2
    item: Valdez R
      type: Person
      first name: Rupa
      last name: Valdez
      member of: University of Virginia, Charlottesville, Virginia, USA.
  slot:
    index: 3
    item: Alexander G
      type: Person
      first name: Greg
      last name: Alexander
      member of: University of Missouri, Columbia, Missouri, USA.
  slot:
    index: 4
    item: Arora S
      type: Person
      first name: Shifali
      last name: Arora
      member of: Rush University, Chicago, Illinois, USA.
  slot:
    index: 5
    item: Bernstam EV
      type: Person
      first name: Elmer V
      last name: Bernstam
      member of: University of Texas Health Science Center, Houston, Texas, USA.
  slot:
    index: 6
    item: Edmunds M
      type: Person
      first name: Margo
      last name: Edmunds
      member of: AcademyHealth, Washington, DC, USA.
  slot:
    index: 7
    item: Kirienko N
      type: Person
      first name: Nikolai
      last name: Kirienko
      member of: Chronology.MD, San Francisco, California, USA.
  slot:
    index: 8
    item: Martin RD
      type: Person
      first name: Ross D
      last name: Martin
      member of: American Medical Informatics Association, Bethesda, Maryland, USA.
  slot:
    index: 9
    item: Sim I
      type: Person
      first name: Ida
      last name: Sim
      member of: University of California San Francisco, San Francisco, California, USA.
  slot:
    index: 10
    item: Skiba D
      type: Person
      first name: Diane
      last name: Skiba
      member of: University of Colorado, Denver, Colorado, USA.
  slot:
    index: 11
    item: Rosenbloom T
      type: Person
      first name: Trent
      last name: Rosenbloom
      member of: Vanderbilt University, Nashville, Tennessee, USA.
created: 2014-11-2T06:00
date last updated: 2025-03-09
issued: 2015-04
dp: 2015 Apr
created: 2014-11-1T06:00
e ISSN: 1527-974X
has issn l: 1067-5027
issue: e1
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: e2
ending page: 6
has place of publication: England
has primary subject term: D057286
has primary subject term: D006291
has primary subject term: D033283
has primary subject term: D018802
has subject term: D003142
has subject term: D003299
has subject term: D006801
has subject term: D012955
has subject term: D014481
source: J Am Med Inform Assoc. 2015-04;22(e1):e2-6.
volume: 22

Chronic hepatitis B infection in pregnancy.
pmid: 26019737
abstract: There are no standard guidelines to follow when a patient with chronic hepatitis B infection becomes pregnant or desires pregnancy. Topics to consider include which patients to treat, when to start treatment, what treatment to use and when to stop treatment. Without any prophylaxis or antiviral therapy, a hepatitis B surface antigen and E antigen positive mother has up to a 90% likelihood of vertical transmission of hepatitis B virus (HBV) to child. Standard of care in the United States to prevent perinatal transmission consists of administration of hepatitis B immune globulin and HBV vaccination to the infant. The two strongest risk factors of mother to child transmission (MTCT) of HBV infection despite immunoprophylaxis are high maternal HBV viral load and high activity of viral replication. The goal is to prevent transmission of HBV at birth by decreasing viral load and/or decreasing activity of the virus. Although it is still somewhat controversial, most evidence shows that starting antivirals in the third trimester is effective in decreasing MTCT without affecting fetal development. There is a growing body of literature supporting the safety and efficacy of antiviral therapies to reduce MTCT of hepatitis B. There are no formal recommendations regarding which agent to choose. Tenofovir, lamivudine and telbivudine have all been proven efficacious in decreasing viral load at birth without known birth defects, but final decision of which antiviral medication to use will have to be determined by physician and patient. The antivirals may be discontinued immediately if patient is breastfeeding, or within first four weeks if infant is being formula fed.
doi: 10.4254/wjh.v7.i9.1233
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lamberth JR
      type: Person
      first name: Jennifer R
      last name: Lamberth
      member of: Jennifer R Lamberth, Sheila C Reddy, Jen-Jung Pan, Kevin J Dasher, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
  slot:
    index: 2
    item: Reddy SC
      type: Person
      first name: Sheila C
      last name: Reddy
      member of: Jennifer R Lamberth, Sheila C Reddy, Jen-Jung Pan, Kevin J Dasher, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
  slot:
    index: 3
    item: Pan JJ
      type: Person
      first name: Jen-Jung
      last name: Pan
      member of: Jennifer R Lamberth, Sheila C Reddy, Jen-Jung Pan, Kevin J Dasher, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
  slot:
    index: 4
    item: Dasher KJ
      type: Person
      first name: Kevin J
      last name: Dasher
      member of: Jennifer R Lamberth, Sheila C Reddy, Jen-Jung Pan, Kevin J Dasher, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
created: 2015-5-29T06:00
date last updated: 2025-03-09
issued: 2015-05-28
dp: 2015 May 28
ISSN: 1948-5182
issue: 9
has NLM journal title abbreviation: World J Hepatol
publication name: World journal of hepatology
language: eng
has national library of medicine journal id: 101532469
derived from: NLM
starting page: 1233
ending page: 7
has place of publication: United States
source: World J Hepatol. 2015-05-28;7(9):1233-7.
volume: 7

Subcortical volumes differentiate Major Depressive Disorder, Bipolar Disorder, and remitted Major Depressive Disorder.
pmid: 26228406
abstract: Subcortical gray matter regions have been implicated in mood disorders, including Major Depressive Disorder (MDD) and Bipolar Disorder (BD). It is unclear, however, whether or how these regions differ among mood disorders and whether such abnormalities are state- or trait-like. In this study, we examined differences in subcortical gray matter volumes among euthymic BD, MDD, remitted MDD (RMD), and healthy (CTL) individuals. Using automated gray matter segmentation of T1-weighted MRI images, we estimated volumes of 16 major subcortical gray matter structures in 40 BD, 57 MDD, 35 RMD, and 61 CTL individuals. We used multivariate analysis of variance to examine group differences in these structures, and support vector machines (SVMs) to assess individual-by-individual classification. Analyses yielded significant group differences for caudate (p = 0.029) and ventral diencephalon (VD) volumes (p = 0.003). For the caudate, both the BD (p = 0.004) and the MDD (p = 0.037) participants had smaller volumes than did the CTL participants. For the VD, the MDD participants had larger volumes than did the BD and CTL participants (ps < 0.005). SVM distinguished MDD from BD with 59.5% accuracy. These findings indicate that mood disorders are characterized by anomalies in subcortical gray matter volumes and that the caudate and VD contribute uniquely to differential affective pathology. Identifying abnormalities in subcortical gray matter may prove useful for the prevention, diagnosis, and treatment of mood disorders.
rights: Copyright © 2015. Published by Elsevier Ltd.
has PII: S0022-3956(15)00173-9
doi: 10.1016/j.jpsychires.2015.06.002
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Sacchet MD
      type: Person
      first name: Matthew D
      last name: Sacchet
      member of: Neurosciences Program, Stanford University, Stanford, CA, USA; Department of Psychology, Stanford University, Stanford, CA, USA. Electronic address: msacchet@stanford.edu.
  slot:
    index: 2
    item: Livermore EE
      type: Person
      first name: Emily E
      last name: Livermore
      member of: Department of Psychology, Stanford University, Stanford, CA, USA. Electronic address: eliv@stanford.edu.
  slot:
    index: 3
    item: Iglesias JE
      type: Person
      first name: Juan Eugenio
      last name: Iglesias
      member of: Basque Center on Cognition, Brain and Language, San Sebastian - Donostia, Gipuzkoa, Spain. Electronic address: e.iglesias@bcbl.eu.
  slot:
    index: 4
    item: Glover GH
      type: Person
      first name: Gary H
      last name: Glover
      member of: Neurosciences Program, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA; Department of Biophysics, Stanford University, Stanford, CA, USA. Electronic address: gary.glover@stanford.edu.
  slot:
    index: 5
    item: Gotlib IH
      type: Person
      first name: Ian H
      last name: Gotlib
      member of: Neurosciences Program, Stanford University, Stanford, CA, USA; Department of Psychology, Stanford University, Stanford, CA, USA. Electronic address: ian.gotlib@stanford.edu.
created: 2015-8-1T06:00
date last updated: 2025-03-09
issued: 2015-09
dp: 2015 Sep
e ISSN: 1879-1379
has issn l: 0022-3956
has NLM journal title abbreviation: J Psychiatr Res
publication name: Journal of psychiatric research
language: eng
has national library of medicine journal id: 0376331
derived from: NLM
starting page: 91
ending page: 8
has place of publication: England
has primary subject term: D001714Q000473
has primary subject term: D001921Q000473
has primary subject term: D003865Q000473
has subject term: D000328
has subject term: D000704
has subject term: D005260
has subject term: D006801
has subject term: D007091
has subject term: D008279
has subject term: D008297
has subject term: D008875
has subject term: D011569
source: J Psychiatr Res. 2015-09;68():91-8.
volume: 68

Hepatitis B Virus (HBV) Variants in Untreated and Tenofovir Treated Chronic Hepatitis B (CHB) Patients during Pregnancy and Post-Partum Follow-Up.
pmid: 26474400
abstract: Chronic hepatitis B (CHB) is a dynamic disease that may be affected by immune changes in pregnancy. Guidelines suggest consideration of nucleos/tide analogs (NA), i.e., tenofovir, (TDF) in highly viremic mothers to reduce vertical transmission risk. HBV variability affects CHB outcome, but little is known about HBV genetic changes in pregnancy due to immune or NA selection.To evaluate HBV diversity in NA treated or untreated pregnant vs. post-partum CHB carriers.In plasma collected from 21 mothers (7 matching pre/post-partum), HBV serological tests, genotype and viral load were assayed. The HBV pre-surface (S) /S overlapping polymerase (P) (N = 20), pre-core (C) /C (N = 11) and/or full genome PCR amplicons (N = 3) underwent clonal sequence analysis.The median age was 31 y, 71% Asian, 68% genotype B or C, 33% HBV eAg+, 5 received TDF (median HBV DNA 8.5 log IU/ml). In untreated mothers, median antepartum vs. post-partum ALT was 21 vs. 24 U/L and HBV DNA was 2.7 vs. 2.4 log(10) IU/ml. ALT and/or HBV DNA flares occurred during pregnant and/or post-partum period in 47% (10/21). Clonal sequencing antepartum showed the presence of minor a determinant and/or vaccine escape mutants (VEM) but drug resistant variants were infrequent. Analysis of pregnant vs. post-partum samples showed different HBV variants and viral diversity.Differences in immune and/or by NA selective pressures during pregnancy may affect HBV evolution during pregnancy. The presence of minor VEM warrant infant follow-up.
has PII: PONE-D-15-22909
doi: 10.1371/journal.pone.0140070
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Virine B
      type: Person
      first name: Boris
      last name: Virine
      member of: Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, 3280 Hospital Drive NW, University of Calgary, Calgary, AB, Canada.
  slot:
    index: 2
    item: Osiowy C
      type: Person
      first name: Carla
      last name: Osiowy
      member of: Bloodborne Pathogens and Hepatitis Laboratory of the National Microbiology Laboratory, Winnipeg, MB, Canada.
  slot:
    index: 3
    item: Gao S
      type: Person
      first name: Shan
      last name: Gao
      member of: Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, 3280 Hospital Drive NW, University of Calgary, Calgary, AB, Canada; Artifical Liver Centre, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 4
    item: Wang T
      type: Person
      first name: Tong
      last name: Wang
      member of: Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  slot:
    index: 5
    item: Castillo E
      type: Person
      first name: Eliana
      last name: Castillo
      member of: Maternal Disorders in Pregnancy, Section of Internal Medicine, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  slot:
    index: 6
    item: Martin SR
      type: Person
      first name: Steven R
      last name: Martin
      member of: Department of Pediatrics, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  slot:
    index: 7
    item: Lee SS
      type: Person
      first name: Samuel S
      last name: Lee
      member of: Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  slot:
    index: 8
    item: Simmonds K
      type: Person
      first name: Kimberley
      last name: Simmonds
      member of: Alberta Health, Government of Alberta, Edmonton, AB, Canada.
  slot:
    index: 9
    item: van Marle G
      type: Person
      first name: Guido
      last name: van Marle
      member of: Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, 3280 Hospital Drive NW, University of Calgary, Calgary, AB, Canada.
  slot:
    index: 10
    item: Coffin CS
      type: Person
      first name: Carla S
      last name: Coffin
      member of: Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, 3280 Hospital Drive NW, University of Calgary, Calgary, AB, Canada.
created: 2015-10-17T06:00
date last updated: 2025-03-09
issued: 2015
dp: 2015
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 10
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0140070
has place of publication: United States
has primary subject term: D004279Q000235
has primary subject term: D006509Q000175Q000188Q000635
has primary subject term: D006515Q000235
has primary subject term: D018445Q000517
has primary subject term: D049590Q000235
has primary subject term: D011251Q000175Q000188Q000821
has primary subject term: D000068698Q000627
has subject term: D000328
has subject term: D000998Q000627
has subject term: D015415Q000032
has subject term: D005260
has subject term: D016679
has subject term: D006513Q000378
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D011247
has subject term: D011256
has subject term: D013997
has subject term: D019562Q000235
has subject term: D014764Q000378
has subject term: D055815
source: PLoS One. 2015;10(10):e0140070.
volume: 10

Dynamic perfusion assessment during perforator flap surgery: an up-to-date.
pmid: 26609259
abstract: Flap monitoring technology has progressed alongside flap design. The highly variable vascular anatomy and the complexity associated with modern perforator flaps demands dynamic, real-time, intraoperative information about the vessel location, perfusion patterns and flap physiology. Although most surgeons still assess flap perfusion and viability based solely on clinical experience, studies have shown that results may be highly variable and often misleading. Poor judgment of intraoperative perfusion leads to major complications. Employing dynamic perfusion imaging during flap reconstruction has led to a reduced complication rate, lower morbidity, shorter hospital stay, and an overall better result. With the emergence of multiple systems capable of intraoperative flap evaluation, the purpose of this article is to review the two systems that have been widely accepted and are currently used by plastic surgeons: Indocyanine green angiography (ICGA) and dynamic infrared thermography (DIRT).
has PII: cm-88-293
doi: 10.15386/cjmed-484
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Muntean MV
      type: Person
      first name: Maximilian Vlad
      last name: Muntean
      member of: Department of Plastic Surgery, Rehabilitation Hospital, Cluj-Napoca, Romania.
  slot:
    index: 2
    item: Muntean V
      type: Person
      first name: Valentin
      last name: Muntean
      member of: Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  slot:
    index: 3
    item: Ardelean F
      type: Person
      first name: Filip
      last name: Ardelean
      member of: Department of Plastic Surgery, Rehabilitation Hospital, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  slot:
    index: 4
    item: Georgescu A
      type: Person
      first name: Alexandru
      last name: Georgescu
      member of: Department of Plastic Surgery, Rehabilitation Hospital, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
created: 2015-11-27T06:00
date last updated: 2025-03-09
issued: 2015
dp: 2015
ISSN: 1222-2119
has issn l: 1222-2119
issue: 3
has NLM journal title abbreviation: Clujul Med
publication name: Clujul medical (1957)
language: eng
has national library of medicine journal id: 101653053
derived from: NLM
starting page: 293
ending page: 7
has place of publication: Romania
source: Clujul Med. 2015;88(3):293-7.
volume: 88

Comprehensive review of telbivudine in pregnant women with chronic hepatitis B.
pmid: 27028961
abstract: To achieve an evidence-based conclusion regarding the safety and efficacy of telbivudine during pregnancy.A pooled analysis of data from a literature search reported 1739 pregnancy outcomes (1673 live births) from 1725 non-overlapping pregnant women treated with telbivudine. The prevalence of live birth defects (3.6/1000) was similar to that of the non-antiviral controls (3.0/1000) and not increased as compared with overall prevalence (14.5 to 60/1000). No target organ toxicity was identified. The prevalence of spontaneous abortion in pregnant women treated with telbivudine (4.2/1000) was not increased compared with the overall prevalence (16/1000). The mother-to-child transmission rate was significantly reduced in pregnant women treated with telbivudine (0.70%) compared to those treated with the non-antiviral controls (11.9%; P < 0.0001) or compared to the historical rates of hepatitis B virus (HBV)-infected population without antiviral treatment (10%-15%).Cumulatively 489 pregnancy cases have been reported in the telbivudine pharmacovigilance database (with a cut-off date 31 August 2014), of those, 308 had known pregnancy outcomes with 249 cases of live births (239 cases of live birth without congenital anomaly and 10 cases of live birth with congenital anomaly). In the latest antiretroviral pregnancy registry report (1 January 1989 through 31 January 2015) of 27 patients exposed to telbivudine during pregnancy (18, 6 and 3 during first, second and third trimester, respectively) 19 live births were reported and there were no cases of birth defects reported.Telbivudine treatment during pregnancy presents a favorable safety profile without increased rates of live birth defects, spontaneous abortion or elective termination, or fetal/neonatal toxicity. Exposure to telbivudine in the first, second and third trimester of pregnancy has been shown to significantly reduce the risk of HBV transmission from mother to child on the basis of standard immune prophylaxis procedur[cell cut: 2002 characters, first 2000 kept]
doi: 10.4254/wjh.v8.i9.452
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Piratvisuth T
      type: Person
      first name: Teerha
      last name: Piratvisuth
      member of: Teerha Piratvisuth, Department of Medicine, NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University, Songkhla 90110, Thailand.
  slot:
    index: 2
    item: Han GR
      type: Person
      first name: Guo Rong
      last name: Han
      member of: Teerha Piratvisuth, Department of Medicine, NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University, Songkhla 90110, Thailand.
  slot:
    index: 3
    item: Pol S
      type: Person
      first name: Stanislas
      last name: Pol
      member of: Teerha Piratvisuth, Department of Medicine, NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University, Songkhla 90110, Thailand.
  slot:
    index: 4
    item: Dong Y
      type: Person
      first name: Yuhong
      last name: Dong
      member of: Teerha Piratvisuth, Department of Medicine, NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University, Songkhla 90110, Thailand.
  slot:
    index: 5
    item: Trylesinski A
      type: Person
      first name: Aldo
      last name: Trylesinski
      member of: Teerha Piratvisuth, Department of Medicine, NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University, Songkhla 90110, Thailand.
created: 2016-3-31T06:00
date last updated: 2025-03-09
issued: 2016-03-28
dp: 2016 Mar 28
ISSN: 1948-5182
issue: 9
has NLM journal title abbreviation: World J Hepatol
publication name: World journal of hepatology
language: eng
has national library of medicine journal id: 101532469
derived from: NLM
starting page: 452
ending page: 60
has place of publication: United States
source: World J Hepatol. 2016-03-28;8(9):452-60.
volume: 8

Preoperative computed tomography angiography for planning DIEP flap breast reconstruction reduces operative time and overall complications.
pmid: 27047777
abstract: The approach and operative techniques associated with breast reconstruction have steadily been refined since its inception, with abdominal perforator-based flaps becoming the gold standard reconstructive option for women undergoing breast cancer surgery. The current study comprises a cohort of 632 patients, in whom specific operative times are recorded by a blinded observer, and aims to address the potential benefits seen with the use of computer tomography (CT) scanning preoperatively on operative outcomes, complications and surgical times.A prospectively recorded, retrospective review was undertaken of patients undergoing autologous breast reconstruction with a DIEP flap at the St Andrews Centre over a 4-year period from 2010 to 2014. Computed tomography angiography (CTA) scanning of patients began in September 2012 and thus 2 time periods were compared: 2 years prior to the use of CTA scans and 2 years afterwards. For all patients, key variables were collected including patient demographics, operative times, flap harvest time, pedicle length, surgeon experience and complications.In group 1, comprising patients within the period prior to CTA scans, 265 patients underwent 312 flaps; whilst in group 2, the immediately following 2 years, 275 patients had 320 flaps. The use of preoperative CTA scans demonstrated a significant reduction in flap harvest time of 13 minutes (P<0.013). This significant time saving was seen in all flap modifications: unilateral, bilateral and bipedicled DIEP flaps. The greatest time saving was seen in bipedicle flaps, with a 35-minute time saving. The return to theatre rate significantly dropped from 11.2% to 6.9% following the use of CTA scans, but there was no difference in the total failure rate.The study has demonstrated both a benefit to flap harvest time as well as overall operative times when using preoperative CTA. The use of CTA was associated with a significant reduction in complications requiring a return to theatre in the immedi[cell cut: 2208 characters, first 2000 kept]
has PII: gs-05-02-093
doi: 10.3978/j.issn.2227-684X.2015.05.17
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Fitzgerald O'Connor E
      type: Person
      first name: Edmund
      last name: Fitzgerald O'Connor
      member of: 1 STAAR St Andrews Anglia Ruskin Research Group, Anglia Ruskin University, Essex, UK ; 2 St Andrew's Centre for Plastic Surgery and Burns, Room E322, Mayflower Ward, Level 3, Zone E, West Wing, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex CM1 7ET, UK.
  slot:
    index: 2
    item: Rozen WM
      type: Person
      first name: Warren Matthew
      last name: Rozen
      member of: 1 STAAR St Andrews Anglia Ruskin Research Group, Anglia Ruskin University, Essex, UK ; 2 St Andrew's Centre for Plastic Surgery and Burns, Room E322, Mayflower Ward, Level 3, Zone E, West Wing, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex CM1 7ET, UK.
  slot:
    index: 3
    item: Chowdhry M
      type: Person
      first name: Muhammad
      last name: Chowdhry
      member of: 1 STAAR St Andrews Anglia Ruskin Research Group, Anglia Ruskin University, Essex, UK ; 2 St Andrew's Centre for Plastic Surgery and Burns, Room E322, Mayflower Ward, Level 3, Zone E, West Wing, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex CM1 7ET, UK.
  slot:
    index: 4
    item: Band B
      type: Person
      first name: Bassam
      last name: Band
      member of: 1 STAAR St Andrews Anglia Ruskin Research Group, Anglia Ruskin University, Essex, UK ; 2 St Andrew's Centre for Plastic Surgery and Burns, Room E322, Mayflower Ward, Level 3, Zone E, West Wing, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex CM1 7ET, UK.
  slot:
    index: 5
    item: Ramakrishnan VV
      type: Person
      first name: Venkat V
      last name: Ramakrishnan
      member of: 1 STAAR St Andrews Anglia Ruskin Research Group, Anglia Ruskin University, Essex, UK ; 2 St Andrew's Centre for Plastic Surgery and Burns, Room E322, Mayflower Ward, Level 3, Zone E, West Wing, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex CM1 7ET, UK.
  slot:
    index: 6
    item: Griffiths M
      type: Person
      first name: Matthew
      last name: Griffiths
      member of: 1 STAAR St Andrews Anglia Ruskin Research Group, Anglia Ruskin University, Essex, UK ; 2 St Andrew's Centre for Plastic Surgery and Burns, Room E322, Mayflower Ward, Level 3, Zone E, West Wing, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex CM1 7ET, UK.
created: 2016-4-6T06:00
date last updated: 2025-03-09
issued: 2016-04
dp: 2016 Apr
ISSN: 2227-684X
has issn l: 2227-684X
issue: 2
has NLM journal title abbreviation: Gland Surg
publication name: Gland surgery
language: eng
has national library of medicine journal id: 101606638
derived from: NLM
starting page: 93
ending page: 8
has place of publication: China (Republic : 1949- )
source: Gland Surg. 2016-04;5(2):93-8.
volume: 5

Immediate Bilateral Breast Reconstruction with Unilateral Deep Superior Epigastric Artery and Superficial Circumflex Iliac Artery Flaps.
pmid: 27689054
abstract: Autologous breast reconstruction utilizing a perforator flap is an increasingly popular method for reducing donor site morbidity and implant-related complications. However, aberrant anatomy not readily visible on computed tomography angiography is a rare albeit real risk when undergoing perforator flap reconstruction. We present an operative case of a patient who successfully underwent a bilateral breast reconstruction sourced from a unilateral abdominal flap divided into deep superior epigastric artery and superficial circumflex iliac artery flap segments.
doi: 10.5999/aps.2016.43.5.457
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hansen KS
      type: Person
      first name: Keith S
      last name: Hansen
      member of: Division of Plastic and Reconstructive Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 2
    item: Gutwein LG
      type: Person
      first name: Luke G
      last name: Gutwein
      member of: Department of Anatomical Sciences, Saint George's University School of Medicine, Grenada, West Indies.
  slot:
    index: 3
    item: Hartman BC
      type: Person
      first name: Brett C
      last name: Hartman
      member of: Division of Plastic and Reconstructive Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 4
    item: Sood R
      type: Person
      first name: Rajiv
      last name: Sood
      member of: Division of Plastic and Reconstructive Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 5
    item: Socas J
      type: Person
      first name: Juan
      last name: Socas
      member of: Division of Plastic and Reconstructive Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
created: 2016-10-1T06:00
date last updated: 2025-03-09
issued: 2016-09
dp: 2016 Sep
ISSN: 2234-6163
has issn l: 2234-6163
issue: 5
has NLM journal title abbreviation: Arch Plast Surg
publication name: Archives of plastic surgery
language: eng
has national library of medicine journal id: 101577999
derived from: NLM
starting page: 457
ending page: 60
has place of publication: Korea (South)
source: Arch Plast Surg. 2016-09;43(5):457-60.
volume: 43

Current status and strategies for hepatitis B control in Korea.
pmid: 28942624
abstract: Hepatitis B virus (HBV) infection is the most common cause of chronic liver diseases in Korea. After the introduction of the universal HBV vaccination program, the prevalence of hepatitis B surface antigen was markedly reduced, and Korea is now classified as an area of intermediate endemicity for HBV. However, there are still hurdles for elimination of hepatitis B, such as immunoprophylaxis failure against vertical transmission, occurrence of acute hepatitis B among peoples who did not have vaccination at younger age, and rapid increase of immigrant populations from HBV endemic areas. To achieve the World Health Organization goal of viral hepatitis elimination by 2030 in Korea, we suggest comprehensive policies for more effective control of hepatitis B as following: i) insurance coverage for antiviral prophylaxis in mothers with high viremia, ii) screening for hepatitis B seromarkers and catch-up HBV vaccinations of susceptible persons with hepatitis B, iii) establishment of an independent 'viral hepatitis sector' in Centers for Disease Control & Prevention to organize and execute comprehensive strategy for management of viral hepatitis, iv) encourage of management of HBV infection in immigrant populations, v) national campaign to promote awareness of hepatitis B.
has PII: cmh-2017-0104
doi: 10.3350/cmh.2017.0104
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Cho EJ
      type: Person
      first name: Eun Ju
      last name: Cho
      member of: Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  slot:
    index: 2
    item: Kim SE
      type: Person
      first name: Sung Eun
      last name: Kim
      member of: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
  slot:
    index: 3
    item: Suk KT
      type: Person
      first name: Ki Tae
      last name: Suk
      member of: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
  slot:
    index: 4
    item: An J
      type: Person
      first name: Jihyun
      last name: An
      member of: Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  slot:
    index: 5
    item: Jeong SW
      type: Person
      first name: Soung Won
      last name: Jeong
      member of: Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
  slot:
    index: 6
    item: Chung WJ
      type: Person
      first name: Woo Jin
      last name: Chung
      member of: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  slot:
    index: 7
    item: Kim YJ
      type: Person
      first name: Yoon Jun
      last name: Kim
      member of: Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
created: 2017-9-26T06:00
date last updated: 2025-03-09
issued: 2017-09
dp: 2017 Sep
e ISSN: 2287-285X
has issn l: 2287-2728
issue: 3
has NLM journal title abbreviation: Clin Mol Hepatol
publication name: Clinical and molecular hepatology
language: eng
has national library of medicine journal id: 101586730
derived from: NLM
starting page: 205
ending page: 211
has place of publication: Korea (South)
has primary subject term: D000998Q000627
has primary subject term: D006509Q000188Q000453Q000517
has subject term: D054242
has subject term: D005260
has subject term: D006801
has subject term: D011247
has subject term: D015995
has subject term: D056910Q000453
source: Clin Mol Hepatol. 2017-09;23(3):205-211.
volume: 23

Elimination of Vertical Transmission of Hepatitis B in Africa: A Review of Available Tools and New Opportunities.
pmid: 29983265
abstract: This review article focuses on preventing vertical transmission of hepatitis B virus (HBV) among pregnant women living in sub-Saharan Africa (SSA), where disease is endemic and the estimated maternal HBV seroprevalence is >8%. Available interventions that have been studied in low- and middle-income countries are compared in terms of efficacy and effectiveness in clinical practice. Global disease-elimination targets, barriers to HBV-prevention efforts, and critical research gaps are discussed.A PubMed literature search in February 2018 identified relevant studies of interventions to reduce or prevent the transmission of HBV during pregnancy or in the peripartum period. Studies that focused on interventions that are currently available or could be made available in SSA were included. Trials conducted in SSA and other low-income countries were prioritized, although studies of interventions in middle- and high-income countries were included.Among 127 studies and reports included in the review, 60 included data from SSA. The most cost-effective intervention to reduce HBV infection rates in SSA is timely birth-dose vaccination followed by completion of the 3-dose infant-vaccination series. The identification and treatment of pregnant women with elevated HBV viral load to further reduce the risk for vertical transmission in SSA show promise, but efficacy and tolerability trials in Africa are lacking.Scale-up of currently available tools is required to reach HBV disease-elimination goals in SSA. Many countries in SSA are in the process of rolling out national birth-dose vaccination campaigns; this roll out provides an opportunity to evaluate and improve processes in order to expand coverage. Early antenatal care, promotion of facility deliveries, and increased awareness of HBV prevention are also key components of prevention success. Future studies in SSA should identity an HBV-prevention package that is effective, well tolerated, and feasible and can be administered in the[cell cut: 2061 characters, first 2000 kept]
rights: Copyright © 2018 Elsevier Inc. All rights reserved.
has PII: S0149-2918(18)30246-7
doi: 10.1016/j.clinthera.2018.05.016
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Dionne-Odom J
      type: Person
      first name: Jodie
      last name: Dionne-Odom
      member of: Department of Medicine, Division of Infectious Diseases, University of Alabama, Birmingham, Alabama. Electronic address: jdionne@uabmc.edu.
  slot:
    index: 2
    item: Njei B
      type: Person
      first name: Basile
      last name: Njei
      member of: Department of Medicine, Section of Digestive Disease, Yale University, New Haven, Connecticut.
  slot:
    index: 3
    item: Tita ATN
      type: Person
      first name: Alan T N
      last name: Tita
      member of: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Center for Women's Reproductive Health, University of Alabama, Birmingham, Alabama.
created: 2018-7-10T06:00
date last updated: 2025-03-09
issued: 2018-08
dp: 2018 08
e ISSN: 1879-114X
has issn l: 0149-2918
issue: 8
has NLM journal title abbreviation: Clin Ther
publication name: Clinical therapeutics
language: eng
has national library of medicine journal id: 7706726
derived from: NLM
starting page: 1255
ending page: 1267
has place of publication: United States
has primary subject term: D000998Q000627
has primary subject term: D006509Q000175Q000517Q000635
has primary subject term: D017589
has primary subject term: D018445Q000517
has subject term: D017954
has subject term: D057191
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D011247
has subject term: D011251Q000188
has subject term: D011295
has subject term: D016036
has subject term: D014611
source: Clin Ther. 2018-08;40(8):1255-1267.
volume: 40

Current progress in the prevention of mother-to-child transmission of hepatitis B and resulting clinical and programmatic implications.
pmid: 31118703
abstract: There is currently no cure for hepatitis B chronic infections. Because new hepatitis B infections result mainly from perinatal transmission, preventing mother-to-child transmission is essential to reach by 2030 the goal of hepatitis B elimination set by the World Health Organization. The universal administration of hepatitis B vaccine to all infants, regardless of maternal status, starting with the birth dose, is the cornerstone of the strategy for elimination. Additional interventions, such as hepatitis B immune globulin administered to newborns and antiviral prophylaxis administered to hepatitis B infected pregnant women, may contribute to reaching the goal earlier. Hepatitis B immune globulin may remain out for reach of many pregnant women in low- and middle-income countries due to cost and logistic issues, but antivirals are cheap and do not require a cold chain for distribution. However, it has been observed that some viruses harbor mutations associated with escape from vaccine-elicited antibodies following immunization or administration of hepatitis B immune globulin. Also, resistance associated mutations have been described for several drugs used for treatment of hepatitis B infected patients as well as for the prevention of mother-to-child transmission. Whether these mutations have the potential to compromise the prevention of mother-to-child transmission or future treatment of the mother is a question of importance. We propose a review of important recent studies assessing tenofovir disoproxil fumarate for the prevention of mother-to-child transmission, and provides detailed information on the mutations possibly relevant in this setting.
has PII: 171695
doi: 10.2147/IDR.S171695
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Jourdain G
      type: Person
      first name: Gonzague
      last name: Jourdain
      member of: Unit 174-PHPT, Institut de recherche pour le développement (IRD), Marseille, France.Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA.
  slot:
    index: 2
    item: Ngo-Giang-Huong N
      type: Person
      first name: Nicole
      last name: Ngo-Giang-Huong
      member of: Unit 174-PHPT, Institut de recherche pour le développement (IRD), Marseille, France.Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA.
  slot:
    index: 3
    item: Khamduang W
      type: Person
      first name: Woottichai
      last name: Khamduang
      member of: Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
created: 2019-5-24T06:00
date last updated: 2025-03-09
issued: 2019
dp: 2019
ISSN: 1178-6973
has issn l: 1178-6973
has NLM journal title abbreviation: Infect Drug Resist
publication name: Infection and drug resistance
language: eng
has national library of medicine journal id: 101550216
derived from: NLM
starting page: 977
ending page: 987
has place of publication: New Zealand
source: Infect Drug Resist. 2019;12():977-987.
volume: 12

Giant filarial retroperitoneal cyst: a diagnostic dilemma.
pmid: 31223269
abstract: Filarial infections are common in most tropical and subtropical regions of the world. Lymphatic filariasis is caused by either Wuchereria bancrofti, Brugia malayi, or Brugia timori. Extralymphatic filariasis presenting as a primary retroperitoneal mass is very rare despite filariasis being endemic in many regions of India. On review of literature, only a few isolated case reports have been described.We report a case of a huge retroperitoneal cystic mass in a 46-year-old patient who presented with a long-standing, painless progressive abdominal swelling. On examination, there was a large, non-tender, firm swelling of size around 20 × 15 cm occupying the left upper and lower quadrant. The computed tomography of the abdomen was suggestive of thin-walled hypodense cyst of size 25.7 × 15 × 14.3 cm. Laboratory investigations and cyst aspirate were inconclusive for a definite diagnosis. On exploration, a 3-kg cystic mass was removed. The diagnosis of filarial origin was confirmed by the demonstration of microfilaria in the cyst wall and immunochromatographic test (ICT) which was positive.Retroperitoneal lymphatic cyst of filarial origin is very unusual and requires a high index of suspicion if the patient is an inhabitant of an endemic area. The clinical dilemma cannot be resolved with imaging modalities alone, unless a disease-specific manifestation is there. The retroperitoneal cysts often pose a challenge in their diagnosis and management. Small cysts might respond to medical management, whereas large symptomatic cysts will require excision for the final diagnosis and treatment.
has PII: 164
doi: 10.1186/s41182-019-0164-7
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lal P
      type: Person
      first name: Pawan
      last name: Lal
      member of: 1Department of Surgery, Maulana Azad Medical College, New Delhi, India.
  slot:
    index: 2
    item: Bains L
      type: Person
      first name: Lovenish
      last name: Bains
      member of: 1Department of Surgery, Maulana Azad Medical College, New Delhi, India.
  slot:
    index: 3
    item: Sawant G
      type: Person
      first name: Gaurish
      last name: Sawant
      member of: 1Department of Surgery, Maulana Azad Medical College, New Delhi, India.
  slot:
    index: 4
    item: Saini R
      type: Person
      first name: Rahul
      last name: Saini
      member of: 1Department of Surgery, Maulana Azad Medical College, New Delhi, India.
  slot:
    index: 5
    item: Mandal S
      type: Person
      first name: Shramana
      last name: Mandal
      member of: 2Department of Pathology, Maulana Azad Medical College, New Delhi, India.
created: 2019-6-22T06:00
date last updated: 2025-03-09
issued: 2019
dp: 2019
ISSN: 1348-8945
has issn l: 1348-8945
has NLM journal title abbreviation: Trop Med Health
publication name: Tropical medicine and health
language: eng
has national library of medicine journal id: 101215093
derived from: NLM
pg: 37
has place of publication: Japan
source: Trop Med Health. 2019;47():37.
volume: 47

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.
pmid: 31703101
abstract: Metformin is a commonly used antihyperglycaemic agent for the treatment of type 2 diabetes mellitus. Nevertheless, the exact mechanisms of action, underlying the various therapeutic effects of metformin, remain elusive. The goal of this study was to evaluate the alterations in longitudinal whole-blood transcriptome profiles of healthy individuals after a one-week metformin intervention in order to identify the novel molecular targets and further prompt the discovery of predictive biomarkers of metformin response. Next generation sequencing-based transcriptome analysis revealed metformin-induced differential expression of genes involved in intestinal immune network for IgA production and cytokine-cytokine receptor interaction pathways. Significantly elevated faecal sIgA levels during administration of metformin, and its correlation with the expression of genes associated with immune response (CXCR4, HLA-DQA1, MAP3K14, TNFRSF21, CCL4, ACVR1B, PF4, EPOR, CXCL8) supports a novel hypothesis of strong association between metformin and intestinal immune system, and for the first time provide evidence for altered RNA expression as a contributing mechanism of metformin's action. In addition to universal effects, 4 clusters of functionally related genes with a subject-specific differential expression were distinguished, including genes relevant to insulin production (HNF1B, HNF1A, HNF4A, GCK, INS, NEUROD1, PAX4, PDX1, ABCC8, KCNJ11) and cholesterol homeostasis (APOB, LDLR, PCSK9). This inter-individual variation of the metformin effect on the transcriptional regulation goes in line with well-known variability of the therapeutic response to the drug.
has PII: PONE-D-19-13526
doi: 10.1371/journal.pone.0224835
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Briviba M
      type: Person
      first name: Monta
      last name: Briviba
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 2
    item: Silamikelis I
      type: Person
      first name: Ivars
      last name: Silamikelis
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 3
    item: Kalnina I
      type: Person
      first name: Ineta
      last name: Kalnina
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 4
    item: Ansone L
      type: Person
      first name: Laura
      last name: Ansone
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 5
    item: Rovite V
      type: Person
      first name: Vita
      last name: Rovite
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 6
    item: Elbere I
      type: Person
      first name: Ilze
      last name: Elbere
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 7
    item: Radovica-Spalvina I
      type: Person
      first name: Ilze
      last name: Radovica-Spalvina
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 8
    item: Fridmanis D
      type: Person
      first name: Davids
      last name: Fridmanis
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 9
    item: Aladyeva J
      type: Person
      first name: Jekaterina
      last name: Aladyeva
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 10
    item: Konrade I
      type: Person
      first name: Ilze
      last name: Konrade
      member of: Riga Stradins University, Riga, Latvia.
  slot:
    index: 11
    item: Pirags V
      type: Person
      first name: Valdis
      last name: Pirags
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 12
    item: Klovins J
      type: Person
      first name: Janis
      last name: Klovins
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
created: 2019-11-9T06:00
date last updated: 2025-03-09
issued: 2019
dp: 2019
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 11
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0224835
has place of publication: United States
has primary subject term: D001773Q000187Q000378
has primary subject term: D020869
has primary subject term: D005786Q000187
has primary subject term: D008687Q000494
has primary subject term: D059467
has subject term: D000328
has subject term: D015415
has subject term: D002986
has subject term: D019295Q000379
has subject term: D005243Q000737
has subject term: D005260
has subject term: D064368
has subject term: D059014
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D058977
has subject term: D011961
has subject term: D055815
source: PLoS One. 2019;14(11):e0224835.
volume: 14

A review of visualized preoperative imaging with a focus on surgical procedures of the breast.
pmid: 31709172
abstract: Preoperative imaging has become a valuable tool in the planning of perforator flaps, and to date, computed tomographic angiography (CTA) has been shown to be the gold standard in this role. The evidence for this is a source of constant investigation, with advances in newer modalities coming to the fore. A literature review was undertaken to evaluate the current role of relevant imaging modalities in 'visualized surgery'-the ability to map anatomy prior to surgical incision. A focus is made on their accuracy in perforator mapping and correlation with improved clinical outcomes in the context of deep inferior epigastric artery perforator (DIEP) flap surgery. Other applications for preoperative imaging in breast surgery such as imaging of alternate donor sites or of the recipient site and imaging for volumetric assessment are also discussed. Preoperative imaging is integral to the planning of reconstructive breast surgery. This review has discussed the range of imaging techniques used to map and visualize perforator vasculature, and whilst there are varied clinical applications for the imaging modalities, CTA has been demonstrated to be the most precise and to confer the best clinical outcomes. Applications of the other imaging techniques are varied and these should remain as valid alternatives, particularly for patients where radiation or contrast exposure should be limited. Further studies could focus on the development of a more definitive protocol regarding the approach to preoperative imaging in breast surgery.
rights: 2019 Gland Surgery. All rights reserved.
has PII: gs-08-S4-S301
doi: 10.21037/gs.2019.09.07
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Rodkin B
      type: Person
      first name: Bridget
      last name: Rodkin
      member of: Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, Victoria, Australia.Peninsula Clinical School, Central Clinical School at Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
  slot:
    index: 2
    item: Hunter-Smith DJ
      type: Person
      first name: David J
      last name: Hunter-Smith
      member of: Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, Victoria, Australia.Peninsula Clinical School, Central Clinical School at Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
  slot:
    index: 3
    item: Rozen WM
      type: Person
      first name: Warren M
      last name: Rozen
      member of: Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, Victoria, Australia.Peninsula Clinical School, Central Clinical School at Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
created: 2019-11-12T06:00
date last updated: 2025-03-09
issued: 2019-10
dp: 2019 Oct
ISSN: 2227-684X
has issn l: 2227-684X
issue: Suppl 4
has NLM journal title abbreviation: Gland Surg
publication name: Gland surgery
language: eng
has national library of medicine journal id: 101606638
derived from: NLM
starting page: S301
ending page: S309
has place of publication: China (Republic : 1949- )
source: Gland Surg. 2019-10;8(Suppl 4):S301-S309.
volume: 8

Early Start Of Tenofovir Treatment Achieves Better Viral Suppression In Pregnant Women With A High HBV Viral Load: A Real-World Prospective Study.
pmid: 31807036
abstract: To investigate whether tenofovir disoproxil fumarate (TDF) treatment that started from the second trimester had an advantage over TDF treatment that started from the third trimester.Twenty 35-year-old pregnant women with hepatitis B virus (HBV) DNA >2×106 IU/mL were prospectively enrolled in this study. All participants were divided into two subgroups: the second trimester group who started TDF treatment at 24-27 weeks and the third trimester group who started TDF treatment at 28-30 weeks. The primary outcome was the change in serum HBV DNA level from baseline to delivery. Each parameter was tested every 4 weeks from TDF initiation to 3 months postpartum.There were 80 pregnant women in the second trimester group and 49 pregnant women in the third trimester group. The decline in HBV DNA from baseline to delivery was more obvious in the second trimester group (4.8±1.2 log10 IU/mL) than that in the third trimester group (4.3±1.1 log10 IU/mL, p=0.041). The downward shift of haemoglobin (HB) from baseline to delivery was greater in the second trimester group (10.6±10.7 g/L) than in the third trimester group (6.3±12.3 g/L, p=0.041). The decline in HBV DNA from baseline to delivery was linearly related to the start of TDF treatment from the second trimester (β=0.50 and 95% CI: 0.26-0.75, p<0.001). There were no significant differences between the two groups regarding HBV serologic markers and safety indicators.Starting TDF treatment from the second trimester achieved better viral suppression than starting TDF treatment from the third trimester in highly viraemic pregnant women without increasing additional adverse reactions. HB level needed frequent monitoring during treatment to avoid anaemia.Clinical Trial No. NCT02719808.
rights: © 2019 Gao et al.
has PII: 228982
doi: 10.2147/IDR.S228982
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Gao F
      type: Person
      first name: Fan
      last name: Gao
      member of: Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
  slot:
    index: 2
    item: Zhang WT
      type: Person
      first name: Wen-Tao
      last name: Zhang
      member of: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
  slot:
    index: 3
    item: Lin YY
      type: Person
      first name: Ya-Yun
      last name: Lin
      member of: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
  slot:
    index: 4
    item: Wang WM
      type: Person
      first name: Wei-Min
      last name: Wang
      member of: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
  slot:
    index: 5
    item: Xu N
      type: Person
      first name: Na
      last name: Xu
      member of: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
  slot:
    index: 6
    item: Bai GQ
      type: Person
      first name: Gui-Qin
      last name: Bai
      member of: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.
created: 2019-12-7T06:00
date last updated: 2025-03-09
issued: 2019
dp: 2019
ISSN: 1178-6973
has issn l: 1178-6973
has NLM journal title abbreviation: Infect Drug Resist
publication name: Infection and drug resistance
language: eng
has national library of medicine journal id: 101550216
derived from: NLM
starting page: 3475
ending page: 3484
has place of publication: New Zealand
source: Infect Drug Resist. 2019;12():3475-3484.
volume: 12

Determinants of Medication Adherence in Liver Transplant Recipients.
pmid: 31889747
abstract: The aim of this study was to study the determinants of nonadherence to immunosuppressant drugs in liver transplant (LT) recipients using personalised interview and questionnaire methods.The study was conducted on adult LT recipients (deceased donor liver transplant [DDLT] and living donor liver transplant [LDLT]) from the Indian subcontinent, at post-LT clinic visit between July and December 2016. Recipient details included baseline demography, comorbidity, psychological status, details of addiction, indication and type of transplant. Details on financial support for transplantation, admissions for rejection, infection and posttransplant complications were obtained from the hospital records. An adherence questionnaire was completed by direct interview and using a questionnaire.Sixty-seven LT recipients (56 males, median age 48.17 years) constituted the study group. Overall, 11 patients (16.47%) were nonadherent to treatment. LDLT recipients were more adherent than DDLT recipients. Nonadherent recipients were believers in alternative systems of medicine. Medication-related factors such as improper dosing, meagre drug knowledge difficulty in remembering drug dose and timings and economic constraints in continuing medical treatment were statistically significant in nonadherent recipients. Although variation in the tacrolimus levels were significantly more common in the nonadherent group, acute cellular rejection and infection were not statistically different.The prevalence of nonadherence was 16.5%. Determinants of nonadherence were DDLT, belief in alternative medications, high regimen complexity, poor knowledge about medications and cost issues with long-term medications.
rights: © 2019 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.
has PII: S0973-6883(19)30064-7
doi: 10.1016/j.jceh.2019.03.003
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Jain M
      type: Person
      first name: Mayank
      last name: Jain
      member of: Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai 100, India.
  slot:
    index: 2
    item: Venkataraman J
      type: Person
      first name: Jayanthi
      last name: Venkataraman
      member of: Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai 100, India.
  slot:
    index: 3
    item: Reddy MS
      type: Person
      first name: Mettu S
      last name: Reddy
      member of: Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai 100, India.
  slot:
    index: 4
    item: Rela M
      type: Person
      first name: Mohamed
      last name: Rela
      member of: Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai 100, India.
created: 2020-1-1T06:00
date last updated: 2025-03-09
ISSN: 0973-6883
has issn l: 0973-6883
issue: 6
has NLM journal title abbreviation: J Clin Exp Hepatol
publication name: Journal of clinical and experimental hepatology
language: eng
has national library of medicine journal id: 101574137
derived from: NLM
starting page: 676
ending page: 683
has place of publication: India
source: J Clin Exp Hepatol. ;9(6):676-683.
volume: 9

Organ transplantation in persons with HIV.
pmid: 32167973
abstract: : With current antiretroviral therapy, the lifespan of newly diagnosed persons with HIV (PWH) approaches that of uninfected persons. However, metabolic abnormalities related to both the disease and the virus itself, along with comorbidities of aging, have resulted in end-organ disease and organ failure as a major cause of morbidity and mortality. Solid organ transplantation is a life-saving therapy for PWH who have organ failure, and the approval of the HIV Organ Policy Equity Act has opened and expanded opportunities for PWH to donate and receive organs. The current environment of organ transplantation for PWH will be reviewed and future directions of research and treatment will be discussed.
has PII: 00002030-202007010-00002
doi: 10.1097/QAD.0000000000002518
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Kumar RN
      type: Person
      first name: Rebecca N
      last name: Kumar
      member of: Division of Infectious Diseases.
  slot:
    index: 2
    item: Stosor V
      type: Person
      first name: Valentina
      last name: Stosor
      member of: Divisions of Infectious Diseases and Organ Transplantation and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
created: 2020-3-14T06:00
date last updated: 2025-03-09
issued: 2020-07-01
dp: 2020 07 01
e ISSN: 1473-5571
has issn l: 0269-9370
issue: 8
has NLM journal title abbreviation: AIDS
publication name: AIDS (London, England)
language: eng
has national library of medicine journal id: 8710219
derived from: NLM
starting page: 1107
ending page: 1116
has place of publication: England
has primary subject term: D015658Q000150Q000188Q000453
has primary subject term: D054625Q000331
has primary subject term: D014019Q000331
has primary subject term: D009927Q000331
has subject term: D000375
has subject term: D044966Q000627
has subject term: D015897
has subject term: D006291Q000331
has subject term: D006801
has subject term: D016030
has subject term: D016031
has subject term: D016377Q000331
source: AIDS. 2020-07-01;34(8):1107-1116.
volume: 34

Deep Learning Identifies Cardiomyocyte Nuclei With High Precision.
pmid: 32486999
doi: 10.1161/CIRCRESAHA.120.316672
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ali SR
      type: Person
      first name: Shah R
      last name: Ali
      member of: From the Division of Cardiology; Department of Internal Medicine (S.R.A., H.A.S.), The University of Texas Southwestern Medical Center, Dallas.
  slot:
    index: 2
    item: Nguyen D
      type: Person
      first name: Dan
      last name: Nguyen
      member of: Department of Radiation Oncology, Medical Artificial Intelligence and Automation Laboratory (D.N., B.W., S.J.), The University of Texas Southwestern Medical Center, Dallas.
  slot:
    index: 3
    item: Wang B
      type: Person
      first name: Brandon
      last name: Wang
      member of: Department of Radiation Oncology, Medical Artificial Intelligence and Automation Laboratory (D.N., B.W., S.J.), The University of Texas Southwestern Medical Center, Dallas.
  slot:
    index: 4
    item: Jiang S
      type: Person
      first name: Steven
      last name: Jiang
      member of: Department of Radiation Oncology, Medical Artificial Intelligence and Automation Laboratory (D.N., B.W., S.J.), The University of Texas Southwestern Medical Center, Dallas.
  slot:
    index: 5
    item: Sadek HA
      type: Person
      first name: Hesham A
      last name: Sadek
      member of: From the Division of Cardiology; Department of Internal Medicine (S.R.A., H.A.S.), The University of Texas Southwestern Medical Center, Dallas.Center for Regenerative Science and Medicine (H.A.S.), The University of Texas Southwestern Medical Center, Dallas.
created: 2020-6-4T06:00
date last updated: 2025-03-09
issued: 2020-08-14
dp: 2020 08 14
e ISSN: 1524-4571
has issn l: 0009-7330
issue: 5
has NLM journal title abbreviation: Circ Res
publication name: Circulation research
language: eng
has national library of medicine journal id: 0047103
derived from: NLM
starting page: 696
ending page: 698
has place of publication: United States
has primary subject term: D002467Q000378
has primary subject term: http://id.nlm.nih.gov/mesh/D000077321
has primary subject term: D007091
has primary subject term: D008853
has primary subject term: D032383Q000378
has subject term: D000818
has subject term: D015415Q000378
has subject term: D005456Q000737
has subject term: D007150
has subject term: D007211Q000737
has subject term: D019426Q000235Q000378
has subject term: D051379
has subject term: D008822
has subject term: D018995Q000235
has subject term: D015203
has subject term: D020107Q000378
source: Circ Res. 2020-08-14;127(5):696-698.
volume: 127

Nutritional status and the associated factors among people living with HIV: an evidence from cross-sectional survey in hospital based antiretroviral therapy site in Kathmandu, Nepal.
pmid: 32549993
abstract: Nutritional status is the key concern among the people living with HIV but this issue has been failed to be prioritized in HIV strategic plan of Nepal. This study aims to assess the nutritional status among people living with HIV and determine their associated factors.A hospital based cross-sectional study was conducted where 350 people living with HIV attending the ART clinic were selected using systematic random sampling technique. Nutritional status among people living with HIV was assessed through anthropometry, body mass index; Underweight (body mass index < 18.5 kg/m2) and overweight/obesity (body mass index > 23 kg/m2). HIV related clinical factors such CD4 count, WHO stage, opportunistic infection, antiretroviral therapy regimen etc. were collected from the medical records. Socio-demographic data were collected using pretested structured questionnaire through interview technique. Multiple linear regression method was employed to determine the association between different independent factors and body mass index score.The prevalence of underweight was found to be 18.3% (95% CI: 14.3-22.6). Most of the study participants were overweight/obese (39.1%). After subjection to multiple linear regression analysis, it was found that age, being male, being married, being in business occupation, smoking, hemoglobin level and antiretroviral therapy duration were significantly associated with body mass index score. Majority of the participants in our study lacked diversified food (62.3%).Overweight/obesity is an emerging problem among people living with HIV. This group of participants should be screened for the presence of non-communicable disease. This study also highlights the importance of nutritional program being an integral part of HIV/AIDS continuum of care. Therefore, an effort should be made to address the burden of malnutrition by addressing the identified determinants.
rights: © The Author(s) 2020.
has PII: 346
doi: 10.1186/s40795-020-00346-7
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Khatri S
      type: Person
      first name: Samip
      last name: Khatri
      member of: Central Department of Public Health, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.
  slot:
    index: 2
    item: Amatya A
      type: Person
      first name: Archana
      last name: Amatya
      member of: Central Department of Public Health, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.
  slot:
    index: 3
    item: Shrestha B
      type: Person
      first name: Binjwala
      last name: Shrestha
      member of: Central Department of Public Health, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.
created: 2020-6-19T06:00
date last updated: 2025-03-09
issued: 2020
dp: 2020
e ISSN: 2055-0928
has issn l: 2055-0928
has NLM journal title abbreviation: BMC Nutr
publication name: BMC nutrition
language: eng
has national library of medicine journal id: 101672434
derived from: NLM
pg: 22
has place of publication: England
source: BMC Nutr. 2020;6():22.
volume: 6

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response.
pmid: 32780768
abstract: Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the treatment of multiple health conditions, the glycemic response to metformin is highly variable, emphasizing the need for reliable biomarkers. We chose the RNA-Seq-based comparative transcriptomics approach to evaluate the systemic effect of metformin and highlight potential predictive biomarkers of metformin response in drug-naïve volunteers with type 2 diabetes in vivo. The longitudinal blood-derived transcriptome analysis revealed metformin-induced differential expression of novel and previously described genes involved in cholesterol homeostasis (SLC46A1 and LRP1), cancer development (CYP1B1, STAB1, CCR2, TMEM176B), and immune responses (CD14, CD163) after administration of metformin for three months. We demonstrate for the first time a transcriptome-based molecular discrimination between metformin responders (delta HbA1c ≥ 1% or 12.6 mmol/mol) and non-responders (delta HbA1c < 1% or 12.6 mmol/mol), that is determined by expression levels of 56 genes, explaining 13.9% of the variance in the therapeutic efficacy of the drug. Moreover, we found a significant upregulation of IRS2 gene (log2FC 0.89) in responders compared to non-responders before the use of metformin. Finally, we provide evidence for the mitochondrial respiratory complex I as one of the factors related to the high variability of the therapeutic response to metformin in patients with type 2 diabetes mellitus.
has PII: PONE-D-20-08607
doi: 10.1371/journal.pone.0237400
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Briviba M
      type: Person
      first name: Monta
      last name: Briviba
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 2
    item: Ansone L
      type: Person
      first name: Laura
      last name: Ansone
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 3
    item: Silamikelis I
      type: Person
      first name: Ivars
      last name: Silamikelis
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 4
    item: Rovite V
      type: Person
      first name: Vita
      last name: Rovite
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 5
    item: Elbere I
      type: Person
      first name: Ilze
      last name: Elbere
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 6
    item: Silamikele L
      type: Person
      first name: Laila
      last name: Silamikele
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 7
    item: Kalnina I
      type: Person
      first name: Ineta
      last name: Kalnina
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 8
    item: Fridmanis D
      type: Person
      first name: Davids
      last name: Fridmanis
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 9
    item: Sokolovska J
      type: Person
      first name: Jelizaveta
      last name: Sokolovska
      member of: Faculty of Medicine, University of Latvia, Riga, Latvia.
  slot:
    index: 10
    item: Konrade I
      type: Person
      first name: Ilze
      last name: Konrade
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.Faculty of Medicine, Riga Stradins University, Riga, Latvia.
  slot:
    index: 11
    item: Pirags V
      type: Person
      first name: Valdis
      last name: Pirags
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.Faculty of Medicine, University of Latvia, Riga, Latvia.
  slot:
    index: 12
    item: Klovins J
      type: Person
      first name: Janis
      last name: Klovins
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
created: 2020-8-12T06:00
date last updated: 2025-03-09
issued: 2020
dp: 2020
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 8
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0237400
has place of publication: United States
has primary subject term: D001774
has primary subject term: D020869
has primary subject term: D008687Q000494
has subject term: D000368
has subject term: D002784Q000378
has subject term: D005260
has subject term: D006706Q000187Q000235
has subject term: D006801
has subject term: D008297
has subject term: D008875
source: PLoS One. 2020;15(8):e0237400.
volume: 15

Non-coding RNAs regulate angiogenic processes.
pmid: 32784009
abstract: Angiogenesis has critical roles in numerous physiologic processes during embryonic and adult life such as wound healing and tissue regeneration. However, aberrant angiogenic processes have also been involved in the pathogenesis of several disorders such as cancer and diabetes mellitus. Vascular endothelial growth factor (VEGF) is implicated in the regulation of this process in several physiologic and pathologic conditions. Notably, several non-coding RNAs (ncRNAs) have been shown to influence angiogenesis through modulation of expression of VEGF or other angiogenic factors. In the current review, we summarize the function and characteristics of microRNAs and long non-coding RNAs which regulate angiogenic processes. Understanding the role of these transcripts in the angiogenesis can facilitate design of therapeutic strategies to defeat the pathogenic events during this process especially in the human malignancies. Besides, angiogenesis-related mechanisms can improve tissue regeneration after conditions such as arteriosclerosis, myocardial infarction and limb ischemia. Thus, ncRNA-regulated angiogenesis can be involved in the pathogenesis of several disorders.
rights: Copyright © 2020 Elsevier Inc. All rights reserved.
has PII: S1537-1891(20)30207-X
doi: 10.1016/j.vph.2020.106778
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ghafouri-Fard S
      type: Person
      first name: Soudeh
      last name: Ghafouri-Fard
      member of: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Shoorei H
      type: Person
      first name: Hamed
      last name: Shoorei
      member of: Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
  slot:
    index: 3
    item: Mohaqiq M
      type: Person
      first name: Mahdi
      last name: Mohaqiq
      member of: Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
  slot:
    index: 4
    item: Taheri M
      type: Person
      first name: Mohammad
      last name: Taheri
      member of: Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mohammad_823@yahoo.com.
created: 2020-8-14T06:00
date last updated: 2025-03-08
e ISSN: 1879-3649
has issn l: 1537-1891
has NLM journal title abbreviation: Vascul Pharmacol
publication name: Vascular pharmacology
language: eng
has national library of medicine journal id: 101130615
derived from: NLM
pg: 106778
has place of publication: United States
has primary subject term: D042783Q000378Q000473
has primary subject term: D035683Q000235Q000378
has primary subject term: D009369Q000098Q000235Q000378Q000473
has primary subject term: D009389Q000235
has primary subject term: D018919Q000235
has primary subject term: D062085Q000235Q000378
has subject term: D000818
has subject term: D005786
has subject term: D006801
has subject term: D015398
has subject term: D059016
source: Vascul Pharmacol. ;133-134():106778.
volume: 133-134

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients.
pmid: 33125401
abstract: The study was conducted to investigate the effects of metformin treatment on the human gut microbiome's taxonomic and functional profile in the Latvian population, and to evaluate the correlation of these changes with therapeutic efficacy and tolerance.In this longitudinal observational study, stool samples for shotgun metagenomic sequencing-based analysis were collected in two cohorts. The first cohort included 35 healthy nondiabetic individuals (metformin dose 2x850mg/day) at three time-points during metformin administration. The second cohort was composed of 50 newly-diagnosed type 2 diabetes patients (metformin dose-determined by an endocrinologist) at two concordant times. Patients were defined as Responders if their HbA1c levels during three months of metformin therapy had decreased by ≥12.6 mmol/mol (1%), while in Non-responders HbA1c were decreased by <12.6 mmol/mol (1%).Metformin reduced the alpha diversity of microbiota in healthy controls (p = 0.02) but not in T2D patients. At the species level, reduction in the abundance of Clostridium bartlettii and Barnesiella intestinihominis, as well as an increase in the abundance of Parabacteroides distasonis and Oscillibacter unclassified overlapped between both study groups. A large number of group-specific changes in taxonomic and functional profiles was observed. We identified an increased abundance of Prevotella copri (FDR = 0.01) in the Non-Responders subgroup, and enrichment of Enterococcus faecium, Lactococcus lactis, Odoribacter, and Dialister at baseline in the Responders group. Various taxonomic units were associated with the observed incidence of side effects in both cohorts.Metformin effects are different in T2D patients and healthy individuals. Therapy induced changes in the composition of gut microbiome revealed possible mediators of observed short-term therapeutic effects. The baseline composition of the gut microbiome may influence metformin therapy efficacy and tolerance in T2D patients and could [cell cut: 2038 characters, first 2000 kept]
has PII: PONE-D-20-11087
doi: 10.1371/journal.pone.0241338
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Elbere I
      type: Person
      first name: Ilze
      last name: Elbere
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 2
    item: Silamikelis I
      type: Person
      first name: Ivars
      last name: Silamikelis
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 3
    item: Dindune II
      type: Person
      first name: Ilze Izabella
      last name: Dindune
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 4
    item: Kalnina I
      type: Person
      first name: Ineta
      last name: Kalnina
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 5
    item: Briviba M
      type: Person
      first name: Monta
      last name: Briviba
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 6
    item: Zaharenko L
      type: Person
      first name: Linda
      last name: Zaharenko
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 7
    item: Silamikele L
      type: Person
      first name: Laila
      last name: Silamikele
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 8
    item: Rovite V
      type: Person
      first name: Vita
      last name: Rovite
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 9
    item: Gudra D
      type: Person
      first name: Dita
      last name: Gudra
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
  slot:
    index: 10
    item: Konrade I
      type: Person
      first name: Ilze
      last name: Konrade
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.Riga Stradins University, Riga, Latvia.
  slot:
    index: 11
    item: Sokolovska J
      type: Person
      first name: Jelizaveta
      last name: Sokolovska
      member of: Faculty of Medicine, University of Latvia, Riga, Latvia.
  slot:
    index: 12
    item: Pirags V
      type: Person
      first name: Valdis
      last name: Pirags
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.Faculty of Medicine, University of Latvia, Riga, Latvia.
  slot:
    index: 13
    item: Klovins J
      type: Person
      first name: Janis
      last name: Klovins
      member of: Latvian Biomedical Research and Study Centre, Riga, Latvia.
created: 2020-10-31T06:00
date last updated: 2025-03-09
issued: 2020
dp: 2020
created: 2020-10-30T17:13
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 10
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0241338
has place of publication: United States
has primary subject term: D003924Q000188Q000382
has primary subject term: D000069196Q000502
has primary subject term: D008687Q000627
has subject term: D000328
has subject term: D041963Q000187
has subject term: D005260
has subject term: D006801
has subject term: D013294Q000187
has subject term: D008137
has subject term: D008297
has subject term: D064307Q000187
has subject term: D018720Q000187
has subject term: D055815
source: PLoS One. 2020;15(10):e0241338.
volume: 15

Lives of Gender Incongruent Community: An Indian Subset Chants All is Well .
pmid: 33643869
abstract: Gender incongruent individuals are exposed to unique stressors as a result of their minority social position. Poor social support has a further adverse impact on the lives and wellbeing of gender incongruent individuals. There is a paucity of scientific data from India on the socioeconomic status (SES) of gender incongruent community.Aim of the study is to understand and estimate the social support, wellbeing, and SES of gender incongruent individuals in Eastern India.Data of 120 gender incongruent patients from the endocrinology outpatient department of a tertiary care hospital in eastern India were collected. We looked at demographic characteristics, social support, underlying psychiatric comorbidities, and SES. SES was calculated by the Kuppuswamy's socioeconomic status (KSS) scale based on occupation, education, and income.Microsoft Word and Excel were used to generate tables.Most of the gender incongruent individuals were transfeminine. Almost half of them had no history of addiction. Most of them had good support from family and friends and very few (only 3%) had mental health problems. Calculation by KSS scale showed most of the study population lay in the upper middle or lower middle socioeconomic class.Strong support from friends and family appears a key factor for protection against psychiatric comorbidities and an all-round impact on the lives and wellbeing of the study population.
rights: Copyright: © 2021 Indian Journal of Endocrinology and Metabolism.
has PII: IJEM-24-525
doi: 10.4103/ijem.IJEM_501_20
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Majumder A
      type: Person
      first name: Anirban
      last name: Majumder
      member of: Department of Endocrinology, KPC Medical College and Hospital, Kolkata, India.
  slot:
    index: 2
    item: Chatterjee S
      type: Person
      first name: Sudip
      last name: Chatterjee
      member of: Park Clinic, Kolkata, India.
  slot:
    index: 3
    item: Chaudhuri SR
      type: Person
      first name: Soumyabrata Roy
      last name: Chaudhuri
      member of: Department of Endocrinology, KPC Medical College and Hospital, Kolkata, India.
  slot:
    index: 4
    item: Chakraborty S
      type: Person
      first name: Soma
      last name: Chakraborty
      member of: Diabetes-Obesity-Thyroid and Hormone Clinic, Kolkata, India.
created: 2021-3-2T06:00
date last updated: 2025-03-09
created: 2021-3-1T05:38
ISSN: 2230-8210
has issn l: 2230-9500
issue: 6
has NLM journal title abbreviation: Indian J Endocrinol Metab
publication name: Indian journal of endocrinology and metabolism
language: eng
has national library of medicine journal id: 101555690
derived from: NLM
starting page: 525
ending page: 531
has place of publication: India
source: Indian J Endocrinol Metab. ;24(6):525-531.
volume: 24

Author Correction: Development of a functional salivary gland tissue chip with potential for high-content drug screening.
pmid: 33931722
has PII: 10.1038/s42003-021-02103-3
doi: 10.1038/s42003-021-02103-3
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Song Y
      type: Person
      first name: Yuanhui
      last name: Song
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 2
    item: Uchida H
      type: Person
      first name: Hitoshi
      last name: Uchida
      member of: Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 3
    item: Sharipol A
      type: Person
      first name: Azmeer
      last name: Sharipol
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 4
    item: Piraino L
      type: Person
      first name: Lindsay
      last name: Piraino
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 5
    item: Mereness JA
      type: Person
      first name: Jared A
      last name: Mereness
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 6
    item: Ingalls MH
      type: Person
      first name: Matthew H
      last name: Ingalls
      member of: Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 7
    item: Rebhahn J
      type: Person
      first name: Jonathan
      last name: Rebhahn
      member of: David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 8
    item: Newlands SD
      type: Person
      first name: Shawn D
      last name: Newlands
      member of: Department of Otolaryngology, University of Rochester Medical Center, Rochester, NY, USA.Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 9
    item: DeLouise LA
      type: Person
      first name: Lisa A
      last name: DeLouise
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.Materials Science Program, University of Rochester, Rochester, NY, USA.
  slot:
    index: 10
    item: Ovitt CE
      type: Person
      first name: Catherine E
      last name: Ovitt
      member of: Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 11
    item: Benoit DSW
      type: Person
      first name: Danielle S W
      last name: Benoit
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA. benoit@bme.rochester.edu.Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA. benoit@bme.rochester.edu.Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. benoit@bme.rochester.edu.Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA. benoit@bme.rochester.edu.Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. benoit@bme.rochester.edu.Materials Science Program, University of Rochester, Rochester, NY, USA. benoit@bme.rochester.edu.Department of Chemical Engineering, University of Rochester, Rochester, NY, USA. benoit@bme.rochester.edu.Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA. benoit@bme.rochester.edu.
created: 2021-5-2T06:00
date last updated: 2025-03-09
issued: 2021-04-30
dp: 2021 Apr 30
created: 2021-5-1T06:17
e ISSN: 2399-3642
has issn l: 2399-3642
issue: 1
has NLM journal title abbreviation: Commun Biol
publication name: Communications biology
language: eng
has national library of medicine journal id: 101719179
derived from: NLM
pg: 533
has place of publication: England
source: Commun Biol. 2021-04-30;4(1):533.
volume: 4

Computed Tomography Angiography (CTA) before Reconstructive Jaw Surgery Using Fibula Free Flap: Retrospective Analysis of Vascular Architecture.
pmid: 34679563
abstract: Computed tomography angiography (CTA) is widely used in preoperative evaluation of the lower limbs' vascular system for virtual surgical planning (VSP) of fibula free flap (FFF) for jaw reconstruction. The present retrospective clinical study analysed n = 72 computed tomography angiographies (CTA) of lower limbs for virtual surgical planning (VSP) for jaw reconstruction. The purpose of the investigation was to evaluate the morphology of the fibular bone and its vascular supply in CTA imaging, and further, the amount and distribution of periosteal branches (PB) and septo-cutaneous perforators (SCPs) of the fibular artery. A total of 144 lower limbs was assessed (mean age: 58.5 ± 15.3 years; 28 females, 38.9%; 44 males, 61.1%). The vascular system was categorized as regular (type I-A to II-C) in 140 cases (97.2%) regarding the classification by Kim. Absent anterior tibial artery (type III-A, n = 2) and posterior tibial artery (type III-B, n = 2) were detected in the left leg. Stenoses were observed mostly in the fibular artery (n = 11), once in the anterior tibial artery, and twice in the posterior tibial artery. In total, n = 361 periosteal branches (PBs) and n = 231 septo-cutaneous perforators (SCPs) were recorded. While a distribution pattern for PBs was separated into two clusters, a more tripartite distribution pattern for SCPs was found. We conclude that conventional CTA for VSP of free fibula flap (FFF) is capable of imaging and distinguishing SCPs and PBs.
has PII: diagnostics11101865
doi: 10.3390/diagnostics11101865
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Knitschke M
      type: Person
      first name: Michael
      last name: Knitschke
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 2
    item: Baumgart AK
      type: Person
      first name: Anna Katrin
      last name: Baumgart
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 3
    item: Bäcker C
      type: Person
      first name: Christina
      last name: Bäcker
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 4
    item: Adelung C
      type: Person
      first name: Christian
      last name: Adelung
      member of: Department of Radiology, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 5
    item: Roller F
      type: Person
      first name: Fritz
      last name: Roller
      member of: Department of Radiology, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 6
    item: Schmermund D
      type: Person
      first name: Daniel
      last name: Schmermund
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 7
    item: Böttger S
      type: Person
      first name: Sebastian
      last name: Böttger
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 8
    item: Howaldt HP
      type: Person
      first name: Hans-Peter
      last name: Howaldt
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
  slot:
    index: 9
    item: Attia S
      type: Person
      first name: Sameh
      last name: Attia
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany.
created: 2021-10-24T06:00
date last updated: 2025-03-09
issued: 2021-10-11
dp: 2021 Oct 11
created: 2021-10-23T01:01
ISSN: 2075-4418
has issn l: 2075-4418
issue: 10
has NLM journal title abbreviation: Diagnostics (Basel)
publication name: Diagnostics (Basel, Switzerland)
language: eng
has national library of medicine journal id: 101658402
derived from: NLM
has place of publication: Switzerland
source: Diagnostics (Basel). 2021-10-11;11(10):.
volume: 11

Impact of Periosteal Branches and Septo-Cutaneous Perforators on Free Fibula Flap Outcome: A Retrospective Analysis of Computed Tomography Angiography Scans in Virtual Surgical Planning.
pmid: 35127535
abstract: Virtual surgical planning (VSP) for jaw reconstruction with free fibula flap (FFF) became a routine procedure and requires computed tomography angiography (CTA) for preoperative evaluation of the lower limbs vascular system and the bone. The aim of the study was to assess whether the distribution and density of periosteal branches (PB) and septo-cutaneous perforators (SCP) of the fibular artery have an impact on flap success.This retrospective clinical study assessed preoperative CTA of the infra-popliteal vasculature and the small vessel system of 72 patients who underwent FFF surgery. Surgical outcome of flap transfer includes wound healing, subtotal, and total flap loss were matched with the segmental vascular supply.A total of 72 patients (28 females, 38.9 %; 44 males, 61.1 %) fulfilled the study inclusion criteria. The mean age was 58.5 (± 15.3 years). Stenoses of the lower limbs' vessel (n = 14) were mostly detected in the fibular artery (n = 11). Flap success was recorded in n = 59 (82.0%), partial flap failure in n = 4 (5.5%) and total flap loss in n = 9 (12.5%). The study found a mean number (± SD) of 2.53 ± 1.60 PBs and 1.39 ± 1.03 SCPs of the FA at the donor-site. The proximal FFF segment of poly-segmental jaw reconstruction showed a higher rate of PB per flap segment than in the distal segments. Based on the total number of prepared segments (n = 121), 46.7% (n = 7) of mono-, 40.4% (n = 21) of bi-, and 31.5 % (n = 17) of tri-segmental fibula flaps were at least supplied by one PB in the success group. Overall, this corresponds to 37.2% (45 out of 121) of all successful FFF. For total flap loss (n = 14), a relative number of 42.9% (n = 6) of distinct supplied segments was recorded. Wound healing disorder of the donor site was not statistically significant influenced by the detected rate of SCP.In general, a correlation between higher rates of PB and SCP and the flap success could not be statistically proved by the study sample. We conclude, that preoperat[cell cut: 2099 characters, first 2000 kept]
rights: Copyright © 2022 Knitschke, Baumgart, Bäcker, Adelung, Roller, Schmermund, Böttger, Streckbein, Howaldt and Attia.
doi: 10.3389/fonc.2021.821851
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Knitschke M
      type: Person
      first name: Michael
      last name: Knitschke
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 2
    item: Baumgart AK
      type: Person
      first name: Anna Katrin
      last name: Baumgart
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 3
    item: Bäcker C
      type: Person
      first name: Christina
      last name: Bäcker
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 4
    item: Adelung C
      type: Person
      first name: Christian
      last name: Adelung
      member of: Department of Diagnostic and Interventional Radiology and Pediatric Radiology, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 5
    item: Roller F
      type: Person
      first name: Fritz
      last name: Roller
      member of: Department of Diagnostic and Interventional Radiology and Pediatric Radiology, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 6
    item: Schmermund D
      type: Person
      first name: Daniel
      last name: Schmermund
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 7
    item: Böttger S
      type: Person
      first name: Sebastian
      last name: Böttger
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 8
    item: Streckbein P
      type: Person
      first name: Philipp
      last name: Streckbein
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 9
    item: Howaldt HP
      type: Person
      first name: Hans-Peter
      last name: Howaldt
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
  slot:
    index: 10
    item: Attia S
      type: Person
      first name: Sameh
      last name: Attia
      member of: Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Giessen, Germany.
created: 2022-2-8T06:00
date last updated: 2025-03-09
issued: 2021
dp: 2021
created: 2022-2-7T05:34
ISSN: 2234-943X
has issn l: 2234-943X
has NLM journal title abbreviation: Front Oncol
publication name: Frontiers in oncology
language: eng
has national library of medicine journal id: 101568867
derived from: NLM
pg: 821851
has place of publication: Switzerland
source: Front Oncol. 2021;11():821851.
volume: 11

Round window stimulation with an interface coupler demonstrates proof of concept.
pmid: 35606210
abstract: To mechanically stimulate the round window (RW) membrane, an actuator with an interface coupler (IC) has the potential to improve sound transmission to the cochlea as compared to the most used RW stimulation device implanted today. If a proof-of-concept IC prototype shows promise as compared the most common method for RW stimulation, there is potential that future design development of an IC will be worthwhile.A variety of hearing pathologies resulting in mixed and conductive hearing loss can be addressed by mechanically stimulating the RW to transmit sound to the cochlea. The most common method for RW stimulation is with the floating mass transducer (FMT, Med-El). However, the FMT suffers poor sound transmission and unreliable device positioning. The dynamic range and bandwidth of the FMT as a RW stimulator is limited because the entire FMT needs freedom to vibrate. Thus the FMT has difficulty overcoming its own inertia and it cannot be stabilized in a manner that may limit its motion. Here we test an idea of using a generic actuator that vibrates on one side while stationary and held stable on the other (unlike the FMT), and coupling the actuator vibration to the RW membrane with a proof-of-concept IC designed to safely transmit sound to the cochlea. We determine if this proof-of-concept IC can perform as well or better than the FMT in one specimen. If so, further developments of the IC would be worthwhile.RW sound transmission comparison was made between an ideally implanted FMT and a proof-of-concept IC prototype driven by a piezoelectric stack actuator with vibrating tip in a fresh human temporal bone. Velocities of stapes, FMT, and IC actuator were measured with laser Doppler vibrometry to determine bandwidth, linearity, and dynamic range of cochlear sound transmission.Stimulation with proof-of-concept prototype of the IC provided increased sound transmission, more linear output for larger dynamic range, and wider frequency range as compared to the FMT. This e[cell cut: 3398 characters, first 2000 kept]
rights: Copyright © 2022 Elsevier B.V. All rights reserved.
has PII: S0378-5955(22)00081-8
doi: 10.1016/j.heares.2022.108512
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Frear DL
      type: Person
      first name: Darcy L
      last name: Frear
      member of: Speech and Hearing Bioscience and Technology Program, Harvard University, Boston, MA, USA; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, USA. Electronic address: dlfrear@gmail.com.
  slot:
    index: 2
    item: Nakajima HH
      type: Person
      first name: Hideko Heidi
      last name: Nakajima
      member of: Speech and Hearing Bioscience and Technology Program, Harvard University, Boston, MA, USA; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, MA, USA. Electronic address: heidi_nakajima@meei.harvard.edu.
created: 2022-5-24T06:00
date last updated: 2025-03-09
issued: 2022-08
dp: 2022 08
created: 2022-5-23T22:04
e ISSN: 1878-5891
has issn l: 0378-5955
has NLM journal title abbreviation: Hear Res
publication name: Hearing research
language: eng
has national library of medicine journal id: 7900445
derived from: NLM
pg: 108512
has place of publication: Netherlands
has primary subject term: D009998
has primary subject term: D012405Q000502
has subject term: D000161Q000379
has subject term: D006801
has subject term: D007188
has subject term: D013199Q000502
has subject term: D013701Q000502
has subject term: D014732
source: Hear Res. 2022-08;421():108512.
volume: 421

Improving the Safety of DIEP Flap Transplantation: Detailed Perforator Anatomy Study Using Preoperative CTA.
pmid: 35629124
abstract: Background: Deep inferior epigastric perforator and muscle sparing transverse rectus abdominis muscle flaps are commonly used flaps for autologous breast reconstruction. CT-angiography allows to analyse the perforator course preoperatively. Our aim was to compare the different aspects of perforator anatomy in the most detailed study. Methods: CT-angiographies of 300 female patients with autologous breast reconstruction of 10 years were analysed regarding the anatomy of the deep inferior epigastric artery and every perforator. Results: Overall, 2260 perforators were included. We identified correlations regarding the DIEA branching point and number of perforators and their intramuscular course. The largest perforator emerged more often from the medial branch of the DIEA than the smaller perforators (70% (416/595) vs. 54% (878/1634), p < 0.001) and more often had a direct connection to the SIEV (large 67% (401/595) vs. small 39% (634/1634), p < 0.01). Medial row perforators were larger than the laterals (lateral 1.44 mm ± 0.43 (n = 941) vs. medial 1.58 mm ± 0.52 (n = 1304) (p < 0.001)). The larger and more medial the perforator, the more likely it was connected to the SIEV: perforators with direct connection to the SIEV had a diameter of 1.65 mm ± 0.53 (n = 1050), perforators with indirect connection had a diameter of 1.43 ± 0.43 (n = 1028), perforators without connection had a diameter of 1.31 mm ± 0.37 (n = 169) (p < 0.001). Medial perforators were more often directly connected to the SIEV than lateral perforators (medial 56% (723/1302) vs. lateral 35% (327/941), p < 0.001). A lateral perforator more often had a short intramuscular course than medial perforators (69% (554/800) vs. 45% (474/1055), p < 0.001), which was also more often observed in the case of a small perforator and a caudal exit of the rectus sheath. Conclusion: The largest perforator emerges more often from the medial branch of the DIEA and frequently has a direct connection to the SIEV, making medial[cell cut: 2053 characters, first 2000 kept]
has PII: jpm12050701
doi: 10.3390/jpm12050701
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Frank K
      type: Person
      first name: Katharina
      last name: Frank
      member of: Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 2
    item: Ströbel A
      type: Person
      first name: Armin
      last name: Ströbel
      member of: Center for Clinical Studies, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 3
    item: Ludolph I
      type: Person
      first name: Ingo
      last name: Ludolph
      member of: Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 4
    item: Hauck T
      type: Person
      first name: Theresa
      last name: Hauck
      member of: Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 5
    item: May MS
      type: Person
      first name: Matthias S
      last name: May
      member of: Department of Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 6
    item: Beier JP
      type: Person
      first name: Justus P
      last name: Beier
      member of: Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, 52074 Aachen, Germany.
  slot:
    index: 7
    item: Horch RE
      type: Person
      first name: Raymund E
      last name: Horch
      member of: Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 8
    item: Arkudas A
      type: Person
      first name: Andreas
      last name: Arkudas
      member of: Laboratory for Tissue Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
created: 2022-5-29T06:00
date last updated: 2025-03-09
issued: 2022-04-28
dp: 2022 Apr 28
created: 2022-5-28T01:26
ISSN: 2075-4426
has issn l: 2075-4426
issue: 5
has NLM journal title abbreviation: J Pers Med
publication name: Journal of personalized medicine
language: eng
has national library of medicine journal id: 101602269
derived from: NLM
has place of publication: Switzerland
source: J Pers Med. 2022-04-28;12(5):.
volume: 12

Computed Tomography-Based Deep Learning Nomogram Can Accurately Predict Lymph Node Metastasis in Gastric Cancer.
pmid: 35909203
abstract: Computed tomography is the most commonly used imaging modality for preoperative assessment of lymph node status, but the reported accuracy is unsatisfactory.To evaluate and verify the predictive performance of computed tomography deep learning on the presurgical evaluation of lymph node metastasis in patients with gastric cancer.347 patients were retrospectively selected (training cohort: 242, test cohort: 105). The enhanced computed tomography arterial phase images of gastric cancer were used for lesion segmentation, radiomics and deep learning feature extraction. Three methods were used for feature selection. Support vector machine (SVM) or random forest (RF) was used to build models. The classification performance of the models was evaluated using the area under the receiver operating characteristic curve (AUC). We also established a nomogram that included clinical predictors.The model based on ResNet50-RF showed favorable classification performance and was verified in the test cohort (AUC = 0.9803). The nomogram based on deep learning feature scores and the lymph node status reported by computed tomography showed excellent discrimination. AUC of 0.9978 was achieved in the training cohort and verified in the test cohort (AUC = 0.9914). Decision analysis curve showed the value of nomogram in clinical application.The computed tomography-based deep learning nomogram can accurately and effectively evaluate lymph node metastasis in patients with gastric cancer before surgery.
rights: © 2022. The Author(s).
has PII: 10.1007/s10620-022-07640-3
doi: 10.1007/s10620-022-07640-3
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Guan X
      type: Person
      first name: Xiao
      last name: Guan
      member of: Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, No. 121, Jiangjiayuan Road, Nanjing, 210011, Jiangsu, China.
  slot:
    index: 2
    item: Lu N
      type: Person
      first name: Na
      last name: Lu
      member of: Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, No. 121, Jiangjiayuan Road, Nanjing, 210011, Jiangsu, China.
  slot:
    index: 3
    item: Zhang J
      type: Person
      first name: Jianping
      last name: Zhang
      member of: Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, No. 121, Jiangjiayuan Road, Nanjing, 210011, Jiangsu, China. drzhangjp@njmu.edu.cn.
created: 2022-8-1T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-7-31T23:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1473
ending page: 1481
has place of publication: United States
has primary subject term: D013274Q000473
has primary subject term: http://id.nlm.nih.gov/mesh/D000077321
has subject term: D006801
has subject term: D049451
has subject term: D012189
has subject term: D008207Q000473
has subject term: D014057Q000379
has subject term: D008198Q000000981Q000473
source: Dig Dis Sci. 2023-04;68(4):1473-1481.
volume: 68

Endoscopic Ultrasound-Directed Transgastric ERCP (EDGE) Utilization of Trends Among Interventional Endoscopists.
pmid: 35947304
abstract: Endoscopic ultrasound-directed transgastric ERCP (EDGE) has become standard-of-care therapy at many centers for pancreaticobiliary disease in patients with Roux-en-Y Gastric Bypass. In this study, we aimed to evaluate the opinions and practices of endoscopists who perform EDGE.A 22-question utilization of EDGE survey was sent to 36 advanced endoscopists at tertiary care centers in the United States. The two-section survey included questions regarding advanced endoscopy volume and training at the respective facilities, and questions on specific details of EDGE utilization.Among 36 interventional endoscopists (IE) surveyed, 14 (39%) reported performing > 1000 ERCPs annually. Thirty (83%) offered EDGE as an option for Roux-en-Y gastric bypass patients with previous cholecystectomy. Other options offered included: 19 (53%) offered Laparoscopy-assisted ERCP (LA-ERCP), 7 (19%) offered Single-Balloon ERCP (SBE), and 10 (28%) offered percutaneous drainage (PTC). Twenty (56%) IE performed 10 or less EDGE procedures, while 16 (44%) performed 11 or more. Single-session EDGE was performed by 7 (19%) IE, while 15 (42%) performed dual session, and 13 (36%) performed both. 19 (53%) actively closed fistulas while 17 (47%) let them close spontaneously. Thirty one (86%) reported a technical success rate of 91% to 100%. The most frequently reported immediate adverse event post-procedurally was abdominal pain, reported by 17 IE (47%). Weight gain was reported by 2 IE (6%).EDGE continues to gain in popularity as an option for Roux-en-Y gastric bypass patients requiring pancreaticobiliary interventions, with 24/36 IE (67%) believing that it should be the new standard. In addition, most report a low frequency of post-procedural weight gain.ClinicalTrials.gov Identifier NCT05041608.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07650-1
doi: 10.1007/s10620-022-07650-1
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Shah-Khan SM
      type: Person
      first name: Sardar M
      last name: Shah-Khan
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 2
    item: Zhao E
      type: Person
      first name: Eric
      last name: Zhao
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 3
    item: Tyberg A
      type: Person
      first name: Amy
      last name: Tyberg
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 4
    item: Sarkar S
      type: Person
      first name: Sardar
      last name: Sarkar
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 5
    item: Shahid HM
      type: Person
      first name: Haroon M
      last name: Shahid
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 6
    item: Duarte-Chavez R
      type: Person
      first name: Rodrigo
      last name: Duarte-Chavez
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 7
    item: Gaidhane M
      type: Person
      first name: Monica
      last name: Gaidhane
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA.
  slot:
    index: 8
    item: Kahaleh M
      type: Person
      first name: Michel
      last name: Kahaleh
      member of: Department of Gastroenterology, Rutgers Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, NJ, 08901, USA. mk1611@rutgers.edu.
created: 2022-8-11T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-10T11:30
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1167
ending page: 1177
has place of publication: United States
has primary subject term: D002760Q000009Q000379
has primary subject term: D015390Q000009Q000379
has subject term: D006801
has subject term: D019160Q000379
has subject term: D016099
has subject term: D015430
has subject term: D012189
source: Dig Dis Sci. 2023-04;68(4):1167-1177.
volume: 68

Impact of Disease Activity and Inflammatory Bowel Disease Subtype on Quality of Life in Preconception and Pregnant Patients.
pmid: 35930124
abstract: Inflammatory bowel disease (IBD) and pregnancy both impact health-related quality of life (HRQoL). However, little is known about IBD-related HRQoL around pregnancy.To assess the trajectory and predictors of HRQoL in preconception and pregnant patients with Crohn's disease (CD) and ulcerative colitis (UC).Preconception and pregnant patients with IBD were followed prospectively from preconception to twelve months postpartum at a tertiary referral centre. Participants completed the Short IBD Questionnaire (SIBDQ) and were assessed for clinical disease activity (modified Harvey Bradshaw Index or partial Mayo score) and objective disease activity (C-reactive protein [CRP], fecal calprotectin [FCP]).A total of 61 patients with IBD (25 CD, 36 UC) were included. During preconception, patients with UC had higher SIBDQ bowel and social sub-scores than those with CD, but this reversed during postpartum. Patients with CD but not UC developed a significant, sustained improvement in SIBDQ upon becoming pregnant, which persisted into 12 months postpartum. In a multivariable linear regression model, clinical disease activity negatively predicted SIBDQ at every pregnancy timepoint and up to 12 months postpartum. SIBDQ was significantly lower in patients with CRP ≥ 8.0 mg/L during trimester 1 (T1), but not later in pregnancy. SIBDQ bowel sub-scores were significantly lower in patients with FCP ≥ 250 mg/kg at T2, T3, and 6 months postpartum.Clinical disease activity is a consistent negative predictor of HRQoL from conception to 12 months postpartum. Patients with UC experience better preconception HRQoL but suffer worse postpartum HRQoL than those with CD.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07638-x
doi: 10.1007/s10620-022-07638-x
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Wang G
      type: Person
      first name: Grace
      last name: Wang
      member of: Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, M5S 1A8, Canada. graceyang.wang@mail.utoronto.ca.
  slot:
    index: 2
    item: Tandon P
      type: Person
      first name: Parul
      last name: Tandon
      member of: Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, M5S 1A8, Canada.Department of Gastroenterology, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5, Canada.
  slot:
    index: 3
    item: Rodriguez N
      type: Person
      first name: Nicole
      last name: Rodriguez
      member of: Faculty of Medicine, University of Alberta, 8440 112 St NW, Edmonton, T6G 2R7, Canada.
  slot:
    index: 4
    item: Ambrosio L
      type: Person
      first name: Lindsy
      last name: Ambrosio
      member of: Faculty of Medicine, University of Alberta, 8440 112 St NW, Edmonton, T6G 2R7, Canada.Division of Gastroenterology, Zeidler Ledcor Centre, University of Alberta, 8540 112 St NW, Edmonton, T6G 2X8, Canada.
  slot:
    index: 5
    item: Sutton RT
      type: Person
      first name: Reed T
      last name: Sutton
      member of: Faculty of Medicine, University of Alberta, 8440 112 St NW, Edmonton, T6G 2R7, Canada.Division of Gastroenterology, Zeidler Ledcor Centre, University of Alberta, 8540 112 St NW, Edmonton, T6G 2X8, Canada.
  slot:
    index: 6
    item: Dieleman LA
      type: Person
      first name: Levinus A
      last name: Dieleman
      member of: Faculty of Medicine, University of Alberta, 8440 112 St NW, Edmonton, T6G 2R7, Canada.Division of Gastroenterology, Zeidler Ledcor Centre, University of Alberta, 8540 112 St NW, Edmonton, T6G 2X8, Canada.
  slot:
    index: 7
    item: Kroeker KI
      type: Person
      first name: Karen I
      last name: Kroeker
      member of: Faculty of Medicine, University of Alberta, 8440 112 St NW, Edmonton, T6G 2R7, Canada.Division of Gastroenterology, Zeidler Ledcor Centre, University of Alberta, 8540 112 St NW, Edmonton, T6G 2X8, Canada.
  slot:
    index: 8
    item: Huang V
      type: Person
      first name: Vivian
      last name: Huang
      member of: Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, M5S 1A8, Canada.Department of Gastroenterology, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5, Canada.
created: 2022-8-6T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-5T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1156
ending page: 1166
has place of publication: United States
has primary subject term: D015212
has primary subject term: D003424Q000175
has primary subject term: D003093Q000175
has subject term: D011247
has subject term: D005260
has subject term: D006801
has subject term: D011788
has subject term: D002097
has subject term: D011795
has subject term: D012720
source: Dig Dis Sci. 2023-04;68(4):1156-1166.
volume: 68

Endoscopic Ultrasound-Guided Antegrade Stent Placement in Patients with Failed ERCP as a Modality of Preoperative and Palliative Biliary Drainage.
pmid: 35947308
abstract: No large studies have addressed the role of endoscopic-ultrasound biliary drainage (EUS-BD) as preoperative biliary drainage (PBD) for malignant extrahepatic biliary obstruction (MEBO). We aimed to discuss the outcomes of EUS antegrade stent placement (EUS-AG) in the preoperative and palliative setting.Retrospective review of patients who underwent EUS-AG for MEBO between December 2019 and December 2021 was done. Primary outcome measures were technical success and clinical success. Secondary outcome measures were number of days of hospitalization postprocedure, adverse events related to EUS-AG procedure, morbidity related to surgery, and 3-month mortality after surgery.54 patients underwent attempt for EUS-AG (mean age 54.8 ± 12.1 years; female 44.4%). Most common primary cancer was pancreatic cancer in 42.1% (23/54) patients. Indication was palliative in 34 (62.9%) patients and PBD in 20 (37%) patients. Level of block was distal in 35 (64.8%) and proximal in 19 (35.1%) patients. Technical success of EUS-AG was 88.7% (47/53). Clinical success was seen in 95.7% (45/47) patients. Median number of days of hospitalization postprocedure was 1 day. No procedure-related severe adverse events were seen. Of 20 patients who underwent EUS-AG as PBD, 19 had technical success (95%) with clinical success in 94.5% (18/19). Surgery was performed in 11 patients, of whom 10 patients underwent successful PPPD (one intraoperative liver metastasis). Two patients had Clavein-Dindo III/IV complication post-PPPD, with one mortality within 30 days of surgery.EUS-AG is safe and effective after failed ERCP in both preoperative and palliative setting.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07655-w
doi: 10.1007/s10620-022-07655-w
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Sundaram S
      type: Person
      first name: Sridhar
      last name: Sundaram
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India. drsridharsundaram@gmail.com.Homi Bhabha National Institute, Parel, Mumbai, 400012, India. drsridharsundaram@gmail.com.
  slot:
    index: 2
    item: Mane K
      type: Person
      first name: Kiran
      last name: Mane
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India.Homi Bhabha National Institute, Parel, Mumbai, 400012, India.
  slot:
    index: 3
    item: Patil P
      type: Person
      first name: Prachi
      last name: Patil
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India.Homi Bhabha National Institute, Parel, Mumbai, 400012, India.
  slot:
    index: 4
    item: Rathod R
      type: Person
      first name: Raosaheb
      last name: Rathod
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India.Homi Bhabha National Institute, Parel, Mumbai, 400012, India.
  slot:
    index: 5
    item: Jain AK
      type: Person
      first name: Aadish Kumar
      last name: Jain
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India.Homi Bhabha National Institute, Parel, Mumbai, 400012, India.
  slot:
    index: 6
    item: Tyagi U
      type: Person
      first name: Unique
      last name: Tyagi
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India.Homi Bhabha National Institute, Parel, Mumbai, 400012, India.
  slot:
    index: 7
    item: Mehta S
      type: Person
      first name: Shaesta
      last name: Mehta
      member of: Department of Digestive Diseases and Clinical Nutrition, Tata Memorial Hospital, Mumbai, India.Homi Bhabha National Institute, Parel, Mumbai, 400012, India.
created: 2022-8-11T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-10T11:30
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1551
ending page: 1558
has place of publication: United States
has primary subject term: D010190Q000000981Q000601Q000150
has primary subject term: D002779Q000000981Q000209Q000601
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D008875
has subject term: D000368
has subject term: D002760Q000009Q000379
has subject term: D016896
has subject term: D019160Q000379
has subject term: D004322Q000009Q000379
has subject term: D015607
has subject term: D018084Q000009
source: Dig Dis Sci. 2023-04;68(4):1551-1558.
volume: 68

Impact of Medicaid Expansion on Incidence and Mortality from Gastric and Esophageal Cancer.
pmid: 35972583
abstract: Individuals in Medicaid expanded states have increased access to treatment for medical conditions and other health care resources. Esophageal and gastric cancer are associated with several modifiable risk factors (e.g. smoking, drinking, Helicobacter pylori infection). The impact of Medicaid expansion on these cancers incidence and mortality remains uninvestigated.We evaluated the association between Medicaid expansion and gastric and esophageal cancer incidence and mortality in adults aged 25-64. We employed an observational design using a difference-in-differences method with state level data, from 2010 to 2017. Annual, age-adjusted gastric and esophageal cancer incidence and mortality rates, from the CDC Wonder Database, were analyzed. Rates were adjusted for by several socio-demographic factors.Expansion and non-expansion states were similar in percent Hispanic ethnicity and female gender. The non-expansion states had significantly higher proportion of Black race, diabetics, obese persons, smokers, and those living below the federal poverty line. Adjusted analyses demonstrate that expansion states had significantly fewer new cases of gastric cancer: - 1.6 (95% CI 0.2-3.5; P = 0.08) per 1,000,000 persons per year. No significant association was seen between Medicaid expansion and gastric cancer mortality (0.46 [95% CI - 0.08 to 0.17; P = 0.46]) and esophageal cancer incidence (0.8 [95% CI - 0.08 to 0.24; P = 0.33]) and mortality (1.0 [95% CI - 0.06 to 0.26; P = 0.21]) in multivariable analyses.States that adopted Medicaid expansion saw a decrease in gastric cancer incidence when compared to states that did not expand Medicaid. Though several factors may influence gastric cancer incidence, this association is important to consider during health policy negotiations.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07659-6
doi: 10.1007/s10620-022-07659-6
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Niroomand E
      type: Person
      first name: Elaheh
      last name: Niroomand
      member of: Department of Internal Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, Miami, FL, 33136, USA.
  slot:
    index: 2
    item: Kumar SR
      type: Person
      first name: Smriti Rajita
      last name: Kumar
      member of: Department of Internal Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, Miami, FL, 33136, USA.
  slot:
    index: 3
    item: Goldberg D
      type: Person
      first name: David
      last name: Goldberg
      member of: Division of Gastroenterology and Hepatology, University of Miami Miller School of Medicine, Miami, FL, USA.Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL, USA.
  slot:
    index: 4
    item: Kumar S
      type: Person
      first name: Shria
      last name: Kumar
      member of: Division of Gastroenterology and Hepatology, University of Miami Miller School of Medicine, Miami, FL, USA. shriakumar@med.miami.edu.Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL, USA. shriakumar@med.miami.edu.
created: 2022-8-17T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-16T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1178
ending page: 1186
has place of publication: United States
has primary subject term: D004938Q000453
has primary subject term: D016481
has primary subject term: D016480
has primary subject term: D013274Q000453
has subject term: D000328
has subject term: D005260
has subject term: D006801
has subject term: D015994
has subject term: D019458
has subject term: D008484
has subject term: D058991
has subject term: D014481Q000453
source: Dig Dis Sci. 2023-04;68(4):1178-1186.
volume: 68

Fecal Microbiome Associated with Both Colon Adenomas and Lifetime Colorectal Cancer Risk.
pmid: 35986796
abstract: Increasing data indicates the gut flora including bacteria and fungi combined with environmental factors are important in the pathogenesis of colorectal cancer (CRC). Understanding differences in the microbiome in patients with colon neoplasia will foster the development of biomarkers for early detection.Determine the association of microbiome with presence of adenomas and predicted CRC risk.In subjects referred for colonoscopy, the NCI CRC risk assessment tool was completed and stool for microbiome analysis as well as fecal immunochemical test (FIT) were collected. We calculated the microbiome alpha diversity using the Shannon index as well as individual bacterial and fungal species.Among 34 patients, we identified 10 with one or more adenomas. Only 2 patients were FIT positive. The median predicted lifetime CRC risk was 2.75% and the prevalence of adenoma was higher in the fourth quartile (P < 0.001). The measured alpha diversity was somewhat higher in patients with adenomas (P = 0.07). We identified 4 bacterial species with an increased relative abundance among patients with adenomas [P < 0.5]. Lifetime CRC risk was associated with 2 specific bacterial species, P. distasonis & E. hermannii [P = 0.05 & 0.09, respectively]. No associations were seen with fungal species and adenoma prevalence or lifetime CRC risk.In addition to a strong correlation of predicted CRC risk and adenoma prevalence, we also found important differences in specific bacterial species and both adenoma prevalence and CRC risk. Larger trials are needed to potentially implement further data in the clinical setting.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07673-8
doi: 10.1007/s10620-022-07673-8
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Alharfi S
      type: Person
      first name: Sarah
      last name: Alharfi
      member of: Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  slot:
    index: 2
    item: Furey N
      type: Person
      first name: Nancy
      last name: Furey
      member of: Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.Division of Gastroenterology, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106-5066, USA.
  slot:
    index: 3
    item: Al-Shakhshir H
      type: Person
      first name: Hilmi
      last name: Al-Shakhshir
      member of: Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
  slot:
    index: 4
    item: Ghannoum M
      type: Person
      first name: Mahmoud
      last name: Ghannoum
      member of: Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  slot:
    index: 5
    item: Cooper GS
      type: Person
      first name: Gregory S
      last name: Cooper
      member of: Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Gregory.cooper@UHhospitals.org.The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Gregory.cooper@UHhospitals.org.Division of Gastroenterology, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106-5066, USA. Gregory.cooper@UHhospitals.org.
created: 2022-8-21T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-20T11:15
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1492
ending page: 1499
has place of publication: United States
has primary subject term: D015179Q000175Q000453Q000473
has primary subject term: D003110
has primary subject term: http://id.nlm.nih.gov/mesh/D000069196
has primary subject term: D000236Q000175Q000453Q000473
has subject term: D006801
has subject term: D003113
has subject term: D005243
has subject term: D055088
source: Dig Dis Sci. 2023-04;68(4):1492-1499.
volume: 68

Long-Term Impact of Endoscopic Gallbladder Stenting for Calculous Cholecystitis in Poor Surgical Candidates: A Multi-center Comparative Study.
pmid: 35989382
abstract: Although long-term stent placement using endoscopic gallbladder stenting (EGBS) reportedly reduces cholecystitis recurrence in patients unfit to undergo cholecystectomy, its efficacy and safety remain uncertain.This study aimed to examine the long-term effect of EGBS in poor surgical candidates of cholecystectomy.A total of 528 high-risk surgical patients with acute calculous cholecystitis met this study's eligibility criteria. The technical success and adverse events (AE) were compared between patients who underwent EGBS and those who underwent percutaneous transhepatic gallbladder drainage (PTGBD). Elective stent exchange and removal were not performed after EGBS. The external tube was removed after improvement of cholecystitis following PTGBD.The technical success rate was significantly lower with EGBS compared to PTGBD (75.4% versus 98.7%, P < 0.001), while the early-AE rate did not differ significantly between the two methods (7.7% versus 4.3%, P = 0.146). The 1-, 3-, and 5-year cumulative incidence rates of cholecystitis were 3.8%, 7.2%, and 7.2% with EGBS, and 11.7%, 17.6%, and 30.2% with PTGBD, respectively (P = 0.001). Conversely, those of symptomatic late-AE (except cholecystitis) were 8.2%, 22.7%, and 31.4% with EGBS, and 7.5%, 10.9%, and 13.1% with PTGBD, respectively (P = 0.035). Thus, the 1-, 3-, and 5-year cumulative incidence of overall late-AE was 12.0%, 30.4%, and 40.4% with EGBS, and 19.2%, 28.3%, and 42.5% with PTGBD, respectively (P = 0.649).Long-term stent placement via EGBS is useful for preventing the recurrence of cholecystitis, but the success rate is low and the frequency of other late-AE increases with the prolongation of the indwelling period.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07651-0
doi: 10.1007/s10620-022-07651-0
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Inoue T
      type: Person
      first name: Tadahisa
      last name: Inoue
      member of: Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. tinoue-tag@umin.ac.jp.
  slot:
    index: 2
    item: Suzuki Y
      type: Person
      first name: Yuta
      last name: Suzuki
      member of: Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, 5-161 Maehata-cho, Tajimi, Gifu, 507-8522, Japan.
  slot:
    index: 3
    item: Yoshida M
      type: Person
      first name: Michihiro
      last name: Yoshida
      member of: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
  slot:
    index: 4
    item: Naitoh I
      type: Person
      first name: Itaru
      last name: Naitoh
      member of: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
  slot:
    index: 5
    item: Okumura F
      type: Person
      first name: Fumihiro
      last name: Okumura
      member of: Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, 5-161 Maehata-cho, Tajimi, Gifu, 507-8522, Japan.
  slot:
    index: 6
    item: Kitano R
      type: Person
      first name: Rena
      last name: Kitano
      member of: Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
  slot:
    index: 7
    item: Haneda K
      type: Person
      first name: Kenichi
      last name: Haneda
      member of: Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, 5-161 Maehata-cho, Tajimi, Gifu, 507-8522, Japan.
  slot:
    index: 8
    item: Hayashi K
      type: Person
      first name: Kazuki
      last name: Hayashi
      member of: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
  slot:
    index: 9
    item: Yoneda M
      type: Person
      first name: Masashi
      last name: Yoneda
      member of: Department of Gastroenterology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
created: 2022-8-22T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-21T23:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1529
ending page: 1538
has place of publication: United States
has primary subject term: D002764Q000209Q000601
has primary subject term: D041881Q000000981Q000601
has subject term: D006801
has subject term: D005704Q000601
has subject term: D004322Q000009Q000379
has subject term: D015607
has subject term: D012189
has subject term: D016896
source: Dig Dis Sci. 2023-04;68(4):1529-1538.
volume: 68

A Risk Prediction Model for Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis After Stent Insertion for Malignant Biliary Obstruction: Development and Validation.
pmid: 35989385
abstract: Pancreatitis is the most common complication of post-endoscopic retrograde cholangiopancreatography (ERCP). There are currently no prediction models, particularly for post-ERCP pancreatitis (PEP) after biliary stent placement due to malignant biliary obstruction (MBO). To that end, we aim to develop and validate a predictive model for PEP.We retrospectively analyzed the data of patients who underwent ERCP for biliary stent placement due to MBO at the Second Affiliated Hospital of Harbin Medical University from January 1, 2014 to August 31, 2021. The eligible patients were randomly allocated to the development and validation cohorts. A prediction model was built using the development cohort, and the model's effect was validated using a validation cohort.A total of 1524 patients were enrolled, including 1016 in the development cohort and 508 in the validation cohort, with an overall PEP rate of 7.1%. The model's predictors included acute pancreatitis history, the absence of pancreatic duct dilation, nonpancreatic cancer, difficult cannulation, and pancreatic injection. The area under the curve (AUC) in the development cohort was 0.810, and the incidence of PEP in the low-risk, medium-risk, and high-risk groups was 1.53%, 9.12%, and 36.36%, respectively. Meanwhile, the AUC of the validation cohort was 0.781, and the incidence of PEP in the low-risk, medium-risk, and high-risk groups was 4.17%, 8.75%, and 41.67%, respectively.This study was the first to build and validate a risk prediction model, especially for PEP after biliary stent placement due to MBO. Moreover, this model might assist clinicians in identifying high-risk patients and help implement preventive measures in a more timely manner.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07649-8
doi: 10.1007/s10620-022-07649-8
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Fu Z
      type: Person
      first name: Zhifeng
      last name: Fu
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
  slot:
    index: 2
    item: Song J
      type: Person
      first name: Jitao
      last name: Song
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
  slot:
    index: 3
    item: Pi Y
      type: Person
      first name: Yilin
      last name: Pi
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
  slot:
    index: 4
    item: Sun X
      type: Person
      first name: Xianxin
      last name: Sun
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
  slot:
    index: 5
    item: Liu M
      type: Person
      first name: Maoning
      last name: Liu
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
  slot:
    index: 6
    item: Xiao Z
      type: Person
      first name: Zunlong
      last name: Xiao
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China.
  slot:
    index: 7
    item: Chen J
      type: Person
      first name: Jing
      last name: Chen
      member of: Department of Gastroenterology, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang Province, China. chenjingxiaohua@126.com.
created: 2022-8-22T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-21T23:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1574
ending page: 1584
has place of publication: United States
has primary subject term: D010195Q000453
has primary subject term: D002779Q000000981Q000209Q000601
has primary subject term: D009369
has subject term: D006801
has subject term: D002760Q000009
has subject term: D012189
has subject term: D000208
has subject term: D015607Q000009
has subject term: D012307
source: Dig Dis Sci. 2023-04;68(4):1574-1584.
volume: 68

Gastroesophageal Balloon Tamponade Simulation Training with 3D Printed Model Improves Knowledge, Skill, and Confidence.
pmid: 35989387
abstract: Gastroesophageal balloon tamponade (BT) tube placement is a life-saving procedure for refractory bleeding from gastroesophageal varices performed by gastroenterologists, intensivists, internists, and emergency medicine physicians. Despite a recognized need for procedural training, no standard curriculum or assessment tools exist. Given the infrequent performance of this procedure, the development of a representative and accessible simulation model would permit hands-on training to practice and maintain proficiency with BT tube placement.To assess BT tube placement performance before and after a novel simulation-based learning module in gastroenterology fellows and faculty.A 16-item knowledge questionnaire and 22-item procedural skill checklist utilizing a novel 3D printed esophagus model were developed to assess participant knowledge, procedural skills, and confidence prior to our simulation-based intervention and again 8-12 weeks after. Performance metrics were compared pre- and post-intervention within groups and between participant groups.Fifteen gastroenterology fellows (of 15 eligible; 100%) and 14 gastroenterology faculty (of 29 eligible; 48%) completed training. Fellows demonstrated improvement in knowledge (55% to 79%, p < 0.001) and procedural skill (35% to 57%, p < 0.001) following training. Baseline faculty performance did not differ from fellows' performance and post-intervention showed similar improvement in knowledge (61% to 77%, p = 0.001) and procedural skill (40% to 49%, p = 0.147). Overall satisfaction with training was high in both groups post-intervention and faculty felt more confident teaching fellows.The presented learning module offers a unique, low stakes opportunity for learners to improve skills, gain knowledge, and build confidence in placing BT tubes using a realistic simulation model.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07665-8
doi: 10.1007/s10620-022-07665-8
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Mowry C
      type: Person
      first name: Christopher
      last name: Mowry
      member of: Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 2
    item: Kohli R
      type: Person
      first name: Ruhail
      last name: Kohli
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  slot:
    index: 3
    item: Bhat C
      type: Person
      first name: Courtney
      last name: Bhat
      member of: Division of Digestive and Liver Health, Department of Medicine, Denver Health, Denver, CO, USA.
  slot:
    index: 4
    item: Truesdale A
      type: Person
      first name: Aimee
      last name: Truesdale
      member of: Division of Digestive and Liver Health, Department of Medicine, Denver Health, Denver, CO, USA.
  slot:
    index: 5
    item: Menard-Katcher P
      type: Person
      first name: Paul
      last name: Menard-Katcher
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Campus Box B146, Aurora, CO, 80045, USA.
  slot:
    index: 6
    item: Scallon A
      type: Person
      first name: Andrew
      last name: Scallon
      member of: Optogenetics and Neural Engineering (ONE) Core, Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 7
    item: Kriss M
      type: Person
      first name: Michael
      last name: Kriss
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, Campus Box B146, Aurora, CO, 80045, USA. Michael.Kriss@cuanschutz.edu.
created: 2022-8-22T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-21T23:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1187
ending page: 1194
has place of publication: United States
has primary subject term: D000066908Q000379
has primary subject term: D021721
has subject term: D006801
has subject term: D003479
has subject term: D004503Q000379
has subject term: D066330
has subject term: D002983
source: Dig Dis Sci. 2023-04;68(4):1187-1194.
volume: 68

Best Practices in Treatment of Laryngopharyngeal Reflux Disease: A Multidisciplinary Modified Delphi Study.
pmid: 35995882
abstract: Laryngopharyngeal reflux (LPR) is a common otolaryngologic diagnosis. Treatment of presumed LPR remains challenging, and limited frameworks exist to guide treatment.Using RAND/University of California, Los Angeles (UCLA) Appropriateness Methods, a modified Delphi approach identified consensus statements to guide LPR treatment. Experts independently and blindly scored proposed statements on importance, scientific acceptability, usability, and feasibility in a four-round iterative process. Accepted measures reached scores with ≥ 80% agreement in the 7-9 range (on a 9-point Likert scale) across all four categories.Fifteen experts rated 36 proposed initial statements. In round one, 10 (27.8%) statements were rated as valid. In round two, 8 statements were modified based on panel suggestions, and experts subsequently rated 5 of these statements as valid. Round three's discussion refined statements not yet accepted, and in round four, additional voting identified 2 additional statements as valid. In total, 17 (47.2%) best practice statements reached consensus, touching on topics as varied as role of empiric treatment, medication use, lifestyle modifications, and indications for laryngoscopy.Using a well-tested methodology, best practice statements in the treatment of LPR were identified. The statements serve to guide physicians on LPR treatment considerations.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07672-9
doi: 10.1007/s10620-022-07672-9
creator: OrderedList
  length: 18
  slot:
    index: 1
    item: Kamal AN
      type: Person
      first name: Afrin N
      last name: Kamal
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Redwood City, CA, USA. kamala@stanford.edu.
  slot:
    index: 2
    item: Dhar SI
      type: Person
      first name: Shumon I
      last name: Dhar
      member of: Department of Otolaryngology, Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  slot:
    index: 3
    item: Bock JM
      type: Person
      first name: Jonathan M
      last name: Bock
      member of: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
  slot:
    index: 4
    item: Clarke JO
      type: Person
      first name: John O
      last name: Clarke
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Redwood City, CA, USA.
  slot:
    index: 5
    item: Lechien JR
      type: Person
      first name: Jerome R
      last name: Lechien
      member of: Department of Otolaryngology Head Neck Surgery, Elsan Hospital, Paris, France.
  slot:
    index: 6
    item: Allen J
      type: Person
      first name: Jacqueline
      last name: Allen
      member of: Department of Otolaryngology, Head and Neck Surgery, University of Auckland, Auckland, New Zealand.
  slot:
    index: 7
    item: Belafsky PC
      type: Person
      first name: Peter C
      last name: Belafsky
      member of: Department of Otolaryngology/Head and Neck Surgery, Davis School of Medicine, University of California, Sacramento, CA, USA.
  slot:
    index: 8
    item: Blumin JH
      type: Person
      first name: Joel H
      last name: Blumin
      member of: Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
  slot:
    index: 9
    item: Chan WW
      type: Person
      first name: Walter W
      last name: Chan
      member of: Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  slot:
    index: 10
    item: Fass R
      type: Person
      first name: Ronnie
      last name: Fass
      member of: Division of Gastroenterology, Department of Medicine, MetroHealth, Cleveland, OH, USA.
  slot:
    index: 11
    item: Fisichella PM
      type: Person
      first name: P Marco
      last name: Fisichella
      member of: Abbvie Inc., Chicago, IL, USA.
  slot:
    index: 12
    item: Marohn M
      type: Person
      first name: Michael
      last name: Marohn
      member of: Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  slot:
    index: 13
    item: O'Rourke AK
      type: Person
      first name: Ashli K
      last name: O'Rourke
      member of: Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
  slot:
    index: 14
    item: Postma G
      type: Person
      first name: Gregory
      last name: Postma
      member of: Department of Otolaryngology, Head and Neck Surgery, Augusta University, Augusta, GA, USA.
  slot:
    index: 15
    item: Savarino EV
      type: Person
      first name: Edoardo V
      last name: Savarino
      member of: Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
  slot:
    index: 16
    item: Vaezi MF
      type: Person
      first name: Michael F
      last name: Vaezi
      member of: Division of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
  slot:
    index: 17
    item: Carroll TL
      type: Person
      first name: Thomas L
      last name: Carroll
      member of: Division of Otolaryngology and Harvard Medical School, Department of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Boston, MA, USA.
  slot:
    index: 18
    item: Akst LM
      type: Person
      first name: Lee M
      last name: Akst
      member of: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
created: 2022-8-23T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-22T23:22
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1125
ending page: 1138
has place of publication: United States
has primary subject term: D057045Q000175Q000628
has primary subject term: D010820
has subject term: D006801
has subject term: D003697
has subject term: D032921
has subject term: D001521
source: Dig Dis Sci. 2023-04;68(4):1125-1138.
volume: 68

Liver Cirrhosis Patients Homozygous for MTHFR C677T Develop Portal Vein Thrombosis 8 Years Earlier Than Wild Type.
pmid: 35999432
abstract: Age at portal vein thrombosis (PVT) in liver cirrhosis (LC) carriers of the methylene tetrahydrofolate reductase (MTHFR) rs1801133 (C → T667 transition) polymorphism has never been addressed; we compared age at PVT in LC patients genotyped for the MTHFR and explored the interrelated clinical and laboratory factors predicting age at PVT.Retrospective cross-sectional cohort study. PVT participants: MTHFR CC n = 36, MTHFR CT n = 53, MTHFR TT n = 19; age, sex, age at PVT, Child-Pugh score, rs1799963 PT polymorphisms (G → A 20,210 transition), plasma HC and natural anticoagulants available for all participants. Age at PVT was lower in MTHFR TT than CT and CC (56 ± 13 vs. 57 ± 13 vs. 64 ± 9 years, p = 0.001); median (IQR) plasma HC was higher in MTHFR TT than in the other groups [(17 (9.4, 23.3) vs 13 (8,14.7) vs 11 (8.9, 12.7) μmol/l, p = 0.03)]. MTHFR TT, male gender and protein C predicted age at PVT (p = 0.02, p = 0.04 and p = 0.08); MTHFR TT and Child-Pugh score predicted plasma HC (p = 0.005 and p = 0.01) as well as low plasma protein C (p < 0.0001 and p = 0.0002). Plasma HC inversely related to protein C in the MTHFR TT group (p < 0.0001). Compound MTHFR TT with PT GA had lower age at PVT compared to MTHFR TT alone (49 ± 18 vs 58 ± 12 years).MTHFR TT anticipates PVT associated with LC by an average of 8 years; MTHFR TT associates with severity of liver disease and to high plasma HC; the latter may contribute to the prematurity of PVT by interfering with the anticoagulant activity of protein C.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07666-7
doi: 10.1007/s10620-022-07666-7
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ames PRJ
      type: Person
      first name: Paul R J
      last name: Ames
      member of: Immune Response & Vascular Disease Unit, Universidade NOVA de Lisboa, Lisbon, Portugal. paul.ames2@nhs.scot.Dumfries & Galloway Royal Infirmary, Cargenbridge, DG2 8RX, Scotland, UK. paul.ames2@nhs.scot.
  slot:
    index: 2
    item: D'Andrea G
      type: Person
      first name: Giovanna
      last name: D'Andrea
      member of: Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  slot:
    index: 3
    item: Arcaro A
      type: Person
      first name: Alessia
      last name: Arcaro
      member of: Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Campobasso, Italy.
  slot:
    index: 4
    item: Marottoli V
      type: Person
      first name: Vincenzo
      last name: Marottoli
      member of: Multimedica Srl, Naples, Italy.
  slot:
    index: 5
    item: Iannaccone L
      type: Person
      first name: Luigi
      last name: Iannaccone
      member of: Multimedica Srl, Naples, Italy.
  slot:
    index: 6
    item: Maraglione M
      type: Person
      first name: Maurizio
      last name: Maraglione
      member of: Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  slot:
    index: 7
    item: Gentile F
      type: Person
      first name: Fabrizio
      last name: Gentile
      member of: Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Campobasso, Italy.
created: 2022-8-24T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-23T23:28
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1332
ending page: 1338
has place of publication: United States
has primary subject term: D042965Q000235
has primary subject term: D020246Q000235Q000150
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D000368
has subject term: D012189
has subject term: D011486
has subject term: D011169Q000473
has subject term: D003430
has subject term: D008103Q000150
has subject term: D005838
has subject term: D006710
source: Dig Dis Sci. 2023-04;68(4):1332-1338.
volume: 68

Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
pmid: 36002674
abstract: TOB1, a member of the transducer of erbB-2 /B-cell translocation gene family, was detected to be down-regulated in ESCC by RNA sequencing. TOB1-AS1, a head-to-head antisense lncRNA with TOB1, was down-regulated in several cancers. However, the roles of them in esophageal squamous cell carcinoma (ESCC) remained unclarified.To investigate the roles and functions of TOB1-AS1 and TOB1 in ESCC tumorigenesis.The expression levels, methylation status, biological function and mechanisms of TOB1-AS1 and TOB1 in ESCC were, respectively, detected.Frequent down-regulation of TOB1-AS1 and TOB1 was verified in esophageal cancer cells and ESCC tissues, and there was a positive correlation between them in ESCC tissues. The CpG sites hypermethylation within proximal promoter of TOB1-AS1 and TOB1 could lead to transcriptional inhibition of both genes. Furthermore, expression and proximal promoter methylation status of TOB1-AS1 or TOB1 may be associated with ESCC patients' prognosis. TOB1-AS1 and TOB1 may function as tumor suppressors by inhibiting growth, migration, and invasion of esophageal cancer cells. Up-regulation of TOB1-AS1 increased expression level of TOB1, and TOB1-AS1 could work as a ceRNA to modulate ATF3 expression via competitively binding with miR-103a-2-5p. Meanwhile, ATF3, as a transcription factor, could regulate transcription of TOB1; down-regulation of TOB1-AS1 in ESCC led to decreased expression of ATF3 through ceRNA mechanism, and further influenced the transcription of TOB1.TOB1-AS1 and TOB1 may act as tumor suppressors and may serve as potential targets for antitumor therapy in ESCC.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07664-9
doi: 10.1007/s10620-022-07664-9
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Dong Z
      type: Person
      first name: Zhiming
      last name: Dong
      member of: Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China.
  slot:
    index: 2
    item: Zhang G
      type: Person
      first name: Guoqiang
      last name: Zhang
      member of: The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  slot:
    index: 3
    item: Lu J
      type: Person
      first name: Juntao
      last name: Lu
      member of: Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China.
  slot:
    index: 4
    item: Guo Y
      type: Person
      first name: Yanli
      last name: Guo
      member of: Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China.
  slot:
    index: 5
    item: Liang J
      type: Person
      first name: Jia
      last name: Liang
      member of: Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China.
  slot:
    index: 6
    item: Shen S
      type: Person
      first name: Supeng
      last name: Shen
      member of: Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China.
  slot:
    index: 7
    item: Guo W
      type: Person
      first name: Wei
      last name: Guo
      member of: Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, China. guowei7303@163.com.
created: 2022-8-25T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-24T23:29
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1316
ending page: 1331
has place of publication: United States
has primary subject term: D000077277Q000473
has primary subject term: D004938Q000235Q000473
has primary subject term: D062085Q000235Q000378
has primary subject term: D035683Q000235Q000378
has subject term: D006801
has subject term: D015536
has subject term: D018450
has subject term: D045744
has subject term: D011379
has subject term: D019175
has subject term: D015972
has subject term: D049109Q000235
has subject term: D025521Q000235Q000378
has subject term: D047908Q000235Q000378
source: Dig Dis Sci. 2023-04;68(4):1316-1331.
volume: 68

P-element-Induced Wimpy-Testis-Like Protein 1 Regulates the Activation of Pancreatic Stellate Cells Through the PI3K/AKT/mTOR Signaling Pathway.
pmid: 36002675
abstract: Pancreatic fibrosis is the main pathological characteristic of chronic pancreatitis (CP) and pancreatic cancer. Pancreatic stellate cells (PSCs) play a critical role in pancreatic fibrosis. Any targets that may have an impact on the activation of PSCs could become potential treatment candidates for CP and pancreatic cancer. Our goal was to investigate the effect of P-element-induced wimpy-testis (PIWI) protein 1 (PIWIL1) on PSC activation.Lentivirus-based RNA interference (RNAi) and overexpression vector construction were used to knock down and over-express the PIWIL1 protein. Immunocytofluorescent staining, western blotting, wound healing assay, transwell assay, and phalloidin staining were used to investigate the effects of PIWIL1 on the secretion of extracellular matrix components (EMC), actin cytoskeleton, and on the invasion and migration abilities of primary PSCs isolated from C57BL/6 mice. Moreover, pancreatic fibrosis was induced by L-arginine in C57BL/6 mice. The expression of PIWIL1 and collagen deposition in vivo were tested by western blotting and Sirius red staining.Expression levels of collagen I, collagen III, and α-smooth muscle actin were significantly decreased in the LV-PIWIL1 group. Compared with the si-PIWIL1 group, significant differences were observed in the expression of desmin, p-PI3K, p-AKT, and p-mTOR in the LV-PIWIL1 group. Furthermore, PIWIL1 suppressed the PSCs' invasion and migration abilities. In a rescue experiment, the PI3K/AKT/mTOR signaling pathway was found to be the underlying mechanism in PSCs activation mediated by PIWIL1.Our findings suggest that PIWIL1 inhibits the activation of PSCs via the PI3K/AKT/mTOR signaling pathway. PIWIL1 is a potential therapeutic target for pancreatic fibrosis.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07605-6
doi: 10.1007/s10620-022-07605-6
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Xue R
      type: Person
      first name: Ran
      last name: Xue
      member of: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Early Drug Development Center, Peking University Cancer Hospital & Institute, Fucheng Road 52, Haidian District, 100142, Beijing, China. xueran2@sina.com.
  slot:
    index: 2
    item: Zhou J
      type: Person
      first name: Jun
      last name: Zhou
      member of: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China.
  slot:
    index: 3
    item: Wu J
      type: Person
      first name: Jing
      last name: Wu
      member of: Department of Medical Oncology, Beijing You-An Hospital, Capital Medical University, Beijing, 100069, China.
  slot:
    index: 4
    item: Meng Q
      type: Person
      first name: Qinghua
      last name: Meng
      member of: Department of Medical Oncology, Beijing You-An Hospital, Capital Medical University, Beijing, 100069, China.
  slot:
    index: 5
    item: Gong J
      type: Person
      first name: Jifang
      last name: Gong
      member of: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Early Drug Development Center, Peking University Cancer Hospital & Institute, Fucheng Road 52, Haidian District, 100142, Beijing, China.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China.
  slot:
    index: 6
    item: Shen L
      type: Person
      first name: Lin
      last name: Shen
      member of: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Early Drug Development Center, Peking University Cancer Hospital & Institute, Fucheng Road 52, Haidian District, 100142, Beijing, China.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China.
created: 2022-8-25T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-24T23:29
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1339
ending page: 1350
has place of publication: United States
has primary subject term: D010190Q000473
has primary subject term: D050500Q000139
has primary subject term: D010182Q000473
has subject term: D008297
has subject term: D051379
has subject term: D000818
has subject term: D010179Q000473
has subject term: D051057Q000378
has subject term: D019869Q000378
has subject term: D058954Q000473
has subject term: D013737Q000378Q000473
has subject term: D002478
has subject term: D008810
has subject term: D015398
has subject term: D058570Q000378
has subject term: D003094Q000378
has subject term: D005355
source: Dig Dis Sci. 2023-04;68(4):1339-1350.
volume: 68

Nintedanib Induces the Autophagy-Dependent Death of Gastric Cancer Cells by Inhibiting the STAT3/Beclin1 Pathway.
pmid: 36002676
abstract: Tyrosine kinase inhibitors are currently the most widely studied targeted therapies for gastric cancer. As a triple tyrosine inhibitor, nintedanib can alleviate the progression of a variety of cancers, but it is poorly studied in gastric cancer.To investigate the effect of nintedanib on gastric cancer.This study investigated nintedanib's effect on gastric cancer autophagy in vivo and in vitro, and the activity and morphological changes of gastric cancer cells were detected by MTT and HE staining. Proliferation, migration, invasion, and EMT-related marker proteins of AGS and MKN-28 cells were detected. The effects of nintedanib on autophagy in gastric cancer cells were detected by acridine orange, immunofluorescence, and Western blotting assays. The regulation of nintedanib on STAT3 and Beclin1 was detected by qPCR and Western blotting assays. Subsequently, the effects of nintedanib on the tumor STAT3/Beclin1 pathway were verified by stably overexpressing STAT3 in gastric cancer cell lines and tumor-bearing experiments in nude mice.The results showed that nintedanib could inhibit gastric cancer cells' proliferation and EMT process. Meanwhile, autophagy was induced in AGS and MKN-28 cells, and the expression of autophagy-related protein Beclin1 was upregulated, and the phosphorylation level of STAT3 was downregulated. Nintedanib inhibited STAT3 phosphorylation and upregulated Beclin1 to inhibit tumor growth in gastric cancer cell lines with stable STAT3 overexpression and tumor-bearing experiments in nude mice.By inhibiting STAT3, nintedanib upregulated Beclin1 and caused autophagic death in gastric cancer cells.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07653-y
doi: 10.1007/s10620-022-07653-y
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zhu H
      type: Person
      first name: Hui
      last name: Zhu
      member of: Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Yinzhou District, Ningbo city, 315000, China. zjnbzhuhui@126.com.
  slot:
    index: 2
    item: Xia MM
      type: Person
      first name: Min-Ming
      last name: Xia
      member of: Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Yinzhou District, Ningbo city, 315000, China.
  slot:
    index: 3
    item: Tong KH
      type: Person
      first name: Ke-Hui
      last name: Tong
      member of: Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Yinzhou District, Ningbo city, 315000, China.
  slot:
    index: 4
    item: Duan WB
      type: Person
      first name: Wen-Biao
      last name: Duan
      member of: Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, 251 Baizhang East Road, Yinzhou District, Ningbo city, 315000, China.
created: 2022-8-25T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-24T23:29
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1280
ending page: 1291
has place of publication: United States
has primary subject term: D013274Q000188Q000235Q000378
has subject term: D000818
has subject term: D051379
has subject term: D000071186Q000235
has subject term: D008819
has subject term: D045744
has subject term: D001343
has subject term: D049109
has subject term: D017209
source: Dig Dis Sci. 2023-04;68(4):1280-1291.
volume: 68

Bi-directional Relationship Between Celiac Disease and Liver Chemistries: A Systematic Review and Meta-Analysis.
pmid: 36002677
abstract: Previous studies have reported conflicting results regarding prevalence of elevated LC (2-70%) in celiac disease (CD). This systematic review and meta-analysis assessed the prevalence of elevated LC at time of CD diagnosis and associated response to GFD. We also report the prevalence of CD in patients with unexplained elevation of LC.Studies assessing LC (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) in CD patients were eligible. Studies with < 50 cases or in pediatric populations were excluded.In total, 20 studies assessing prevalence of elevated LC in 4,265 participants with newly diagnosed CD (mean age = 35.6 ± 6.5 years, 69.8% female) were included. Pooled prevalence of elevated LC was 18.7% (95% CI 13.8-24.8; I2 = 95%). Normalization of elevated LC was seen in 83.1% (95% CI 73.4-89.7; I2 = 79%, 11 studies) of patients after GFD. On meta-regression, age at CD diagnosis, gender, and Marsh grading were not associated with elevated LC. Among 979 participants (7 studies) with unexplained elevation of LC, pooled seroprevalence and biopsy-proven CD was 6.4% (95% CI 2.9-10.3, I2 = 71%) and 4.5% (95% CI 2.6-7.7, I2 = 67%), respectively.Elevated LC are seen in approximately one-fifth of patients at CD diagnosis with majority normalizing after GFD. Age, gender, and degree of intestinal damage are not predictive of elevated LC. In the appropriate clinical scenario, liver tests should be serially monitored in CD reserving workup for additional causes after a trial of GFD. Patients with unexplained elevation of liver tests should be screened for celiac disease.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07663-w
doi: 10.1007/s10620-022-07663-w
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Aggarwal M
      type: Person
      first name: Manik
      last name: Aggarwal
      member of: Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
  slot:
    index: 2
    item: Garg R
      type: Person
      first name: Rajat
      last name: Garg
      member of: Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.
  slot:
    index: 3
    item: Kumar P
      type: Person
      first name: Prabhat
      last name: Kumar
      member of: Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
  slot:
    index: 4
    item: Lindenmeyer CC
      type: Person
      first name: Christina C
      last name: Lindenmeyer
      member of: Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.
  slot:
    index: 5
    item: Wakim-Fleming J
      type: Person
      first name: Jamile
      last name: Wakim-Fleming
      member of: Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.
  slot:
    index: 6
    item: Jansson-Knodell C
      type: Person
      first name: Claire
      last name: Jansson-Knodell
      member of: Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.Celiac Disease Program, Department of Gastroenterology, Hepatology & Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, A3-208, Cleveland, OH, 44195, USA.
  slot:
    index: 7
    item: Rubio-Tapia A
      type: Person
      first name: Alberto
      last name: Rubio-Tapia
      member of: Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA. rubiota@ccf.org.Celiac Disease Program, Department of Gastroenterology, Hepatology & Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, A3-208, Cleveland, OH, 44195, USA. rubiota@ccf.org.
created: 2022-8-25T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-24T23:29
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1369
ending page: 1380
has place of publication: United States
has primary subject term: D002446Q000175Q000453Q000150
has subject term: D002648
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D008297
has subject term: D016036
has subject term: D008099
has subject term: D008111
has subject term: D000410
has subject term: D055050Q000379
source: Dig Dis Sci. 2023-04;68(4):1369-1380.
volume: 68

Efficacy and Predictors of Pain Response to Combined Antioxidants in Children with Chronic Pancreatitis.
pmid: 36030482
abstract: Pain is a major problem in 90% of patients with chronic pancreatitis (CP). Studies evaluating response to antioxidants (AO) are conflicting and no pediatric studies are available.To evaluate markers of oxidative stress (OS), and efficacy and predictors of response to AO in improving pain in children with CP.Antioxidants were given to CP children for 6 months. Subjects were assessed at baseline and post-therapy for pain and markers of OS [serum thiobarbituric acid reactive substances (TBARS), superoxide dismutase (S-SOD)] and antioxidant levels [vitamin C, selenium, total antioxidant capacity-ferric reducing ability of plasma (FRAP)]. Matched healthy controls were assessed for OS and antioxidant levels. Good response was defined as ≥ 50% reduction in number of painful days/month.48 CP children (25 boys, age 13 years) and 14 controls were enrolled. 38/48 cases completed 6 months of therapy. CP cases had higher OS [TBARS (7.8 vs 5.2 nmol/mL; p < 0.001)] and lower antioxidant levels [FRAP (231 vs. 381.3 µmol/L; p = 0.003), vitamin C (0.646 vs. 0.780 mg/dL; p < 0.001)] than controls. Significant reduction in TBARS and S-SOD and increase in FRAP, vitamin C, and selenium occurred after 6 months. 10.5% cases had minor side effects. 26(68%) cases had a good response, with 9(24%) becoming pain-free. Subjects with severe ductal changes had lower median BMI (- 0.73 vs 0.10; p = 0.04) and responded less often than those with mild changes (17/29 vs 9/9; p = 0.036).CP children have higher OS than healthy controls. Antioxidant therapy is safe. Pain response is seen in 68% cases, less often in patients with severe ductal changes.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07676-5
doi: 10.1007/s10620-022-07676-5
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Gopan A
      type: Person
      first name: Amrit
      last name: Gopan
      member of: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.
  slot:
    index: 2
    item: Srivastava A
      type: Person
      first name: Anshu
      last name: Srivastava
      member of: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India. avanianshu@yahoo.com.
  slot:
    index: 3
    item: Mathias A
      type: Person
      first name: Amrita
      last name: Mathias
      member of: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.
  slot:
    index: 4
    item: Yachha SK
      type: Person
      first name: Surender Kumar
      last name: Yachha
      member of: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.
  slot:
    index: 5
    item: Jain SK
      type: Person
      first name: Sunil Kumar
      last name: Jain
      member of: Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  slot:
    index: 6
    item: Mishra P
      type: Person
      first name: Prabhakar
      last name: Mishra
      member of: Department of Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
  slot:
    index: 7
    item: Sarma MS
      type: Person
      first name: Moinak Sen
      last name: Sarma
      member of: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.
  slot:
    index: 8
    item: Poddar U
      type: Person
      first name: Ujjal
      last name: Poddar
      member of: Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.
created: 2022-8-29T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-28T13:59
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1500
ending page: 1510
has place of publication: United States
has primary subject term: D012643Q000627
has primary subject term: D050500Q000150Q000188
has subject term: D008297
has subject term: D006801
has subject term: D002648
has subject term: D000293
has subject term: D000975Q000627Q000378
has subject term: D017392
has subject term: D018384Q000502
has subject term: D001205
has subject term: D010146Q000188
has subject term: D013482
has subject term: D014815Q000627
source: Dig Dis Sci. 2023-04;68(4):1500-1510.
volume: 68

Crohn's Disease Among the Poorest Billion: Burden of Crohn's Disease in Low- and Lower-Middle-Income Countries.
pmid: 36044105
abstract: To establish the epidemiology and patterns of care of Crohn's Disease in low- and lower-middle-income countries.A cross-sectional survey of gastroenterology providers in countries where the world's poorest billion live was conducted to learn more about the state of diagnostic and treatment capacity for Crohn's. Quantitative data were analyzed in R and Excel.A total of 46 survey responses from 15 countries were received, giving a response rate of 54.8%. All responses collected were from providers practicing in Africa and South Asia. The mean number of patients with Crohn's cared for in the last year was 89.5 overall but ranged from 0 reported at one facility in Rwanda to 1000 reported at two different facilities in India. Overall, Crohn's disease made up 20.6% of the inflammatory bowel disease diagnoses reported by survey respondents, with Africa exhibiting a larger proportion of Crohn's compared to ulcerative colitis than Asia. Most providers reported that patients with Crohn's have symptoms for 6-24 months prior to diagnosis and that 26-50% of their patients live in rural areas. The most reported diagnostic challenges are differentiating between Crohn's and intestinal tuberculosis, poor disease awareness, and lack of trained pathologists. The most widely reported challenge in managing Crohn's disease is patients' inability to afford biologics, reported by 65% of providers.Our study suggests there may be a greater burden of Crohn's disease in low- and lower-middle-income countries than is indicated in prior literature. Respondents reported many challenges in diagnosing and treating Crohn's disease.
rights: © 2022. The Author(s).
has PII: 10.1007/s10620-022-07675-6
doi: 10.1007/s10620-022-07675-6
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Rajbhandari R
      type: Person
      first name: Ruma
      last name: Rajbhandari
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. rrajbhandari@bwh.harvard.edu.Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, 02199, USA. rrajbhandari@bwh.harvard.edu.
  slot:
    index: 2
    item: Blakemore S
      type: Person
      first name: Samantha
      last name: Blakemore
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  slot:
    index: 3
    item: Gupta N
      type: Person
      first name: Neil
      last name: Gupta
      member of: Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, 02199, USA.Partners in Health, NCD Synergies, Boston, MA, 02199, USA.
  slot:
    index: 4
    item: Mannan S
      type: Person
      first name: Sara
      last name: Mannan
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  slot:
    index: 5
    item: Nikolli K
      type: Person
      first name: Klejda
      last name: Nikolli
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  slot:
    index: 6
    item: Yih A
      type: Person
      first name: Alison
      last name: Yih
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  slot:
    index: 7
    item: Drown L
      type: Person
      first name: Laura
      last name: Drown
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
  slot:
    index: 8
    item: Bukhman G
      type: Person
      first name: Gene
      last name: Bukhman
      member of: Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, 02199, USA.Partners in Health, NCD Synergies, Boston, MA, 02199, USA.
created: 2022-9-1T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-8-31T11:21
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1226
ending page: 1236
has place of publication: United States
has primary subject term: D003424Q000175Q000453Q000628
has primary subject term: D015212Q000453
has primary subject term: D003093Q000453
has subject term: D006801
has subject term: D003430
has subject term: D003906
source: Dig Dis Sci. 2023-04;68(4):1226-1236.
volume: 68

A Single-Center Experience with Dupilumab for Atopic or Psoriasiform Dermatitis in Patients with Inflammatory Bowel Disease.
pmid: 36064828
abstract: Dupilumab blocks IL4/IL13 and is used in atopic disease. There are concerns that blockade may lead to inflammatory bowel disease (IBD) inception or activity. Limited data exist on the use of this therapy in patients with IBD; we aimed to describe our experience using dupilumab in IBD to treat concomitant atopic dermatitis (AD) or anti-TNF-induced dermatitis.We analyzed the electronic medical records (2018-2022) in a single, tertiary care center to identify patients with IBD on dupilumab. Clinical and demographic data were gathered, including disease location/behavior, personal/family history of atopy, indication for and response to dupilumab, IBD medication history, and adverse events.Seventeen patients (65% Crohn's) were identified with IBD on dupilumab for dermatitis; 9 for severe AD and 8 for a worsened dermatitis, either AD or psoriasiform dermatitis (PD), induced by anti-TNF. They were treated for a median 1.2 [IQR 0.6-2.3] years. All patients had a dermatologic response to dupilumab and remained on dupilumab at last follow-up. No adverse events were identified, including no increase in IBD activity. In those with dermatitis worsened or induced by anti-TNF, all started dupilumab in combination with another biologic: 3 with anti-TNF, 4 with ustekinumab, and 1 with vedolizumab. Seven of the eight had a response to the initial combination of biologics; however, one patient using dupilumab-anti-TNF ultimately changed to combination dupilumab-ustekinumab to achieve resolution of the dermatitis.Dupilumab is safe and effective for dermatitis in patients with IBD, both primary atopic dermatitis and dermatitis induced or worsened by anti-TNF.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07684-5
doi: 10.1007/s10620-022-07684-5
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Spencer EA
      type: Person
      first name: Elizabeth A
      last name: Spencer
      member of: Division of Pediatric Gastroenterology & Nutrition, Department of Pediatrics Mount Sinai, Icahn School of Medicine, 1 Gustave L Levy Place, Box 1656, New York, NY, 10029, USA. elizabeth.spencer@mssm.edu.
  slot:
    index: 2
    item: Dolinger MT
      type: Person
      first name: Michael T
      last name: Dolinger
      member of: Division of Pediatric Gastroenterology & Nutrition, Department of Pediatrics Mount Sinai, Icahn School of Medicine, 1 Gustave L Levy Place, Box 1656, New York, NY, 10029, USA.
  slot:
    index: 3
    item: Dubinsky MC
      type: Person
      first name: Marla C
      last name: Dubinsky
      member of: Division of Pediatric Gastroenterology & Nutrition, Department of Pediatrics Mount Sinai, Icahn School of Medicine, 1 Gustave L Levy Place, Box 1656, New York, NY, 10029, USA.
created: 2022-9-7T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-6T00:09
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1121
ending page: 1124
has place of publication: United States
has primary subject term: D003876Q000175Q000188
has primary subject term: D015212Q000188
has subject term: D006801
has subject term: D000069549Q000627
has subject term: D000079424Q000627
has subject term: D016896
has subject term: D012720
source: Dig Dis Sci. 2023-04;68(4):1121-1124.
volume: 68

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.
pmid: 36066633
abstract: Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.
rights: © 2022. The Author(s).
has PII: 10.1007/s00401-022-02454-z
doi: 10.1007/s00401-022-02454-z
creator: OrderedList
  length: 146
  slot:
    index: 1
    item: Jansen IE
      type: Person
      first name: Iris E
      last name: Jansen
      member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. i.e.jansen@vu.nl.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. i.e.jansen@vu.nl.Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
  slot:
    index: 2
    item: van der Lee SJ
      type: Person
      first name: Sven J
      last name: van der Lee
      member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  slot:
    index: 3
    item: Gomez-Fonseca D
      type: Person
      first name: Duber
      last name: Gomez-Fonseca
      member of: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
  slot:
    index: 4
    item: de Rojas I
      type: Person
      first name: Itziar
      last name: de Rojas
      member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
  slot:
    index: 5
    item: Dalmasso MC
      type: Person
      first name: Maria Carolina
      last name: Dalmasso
      member of: Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.Neurosciences and Complex Systems Unit (ENyS), CONICET, Hospital El Cruce, National University A. Jauretche (UNAJ), Florencio Varela, Argentina.
  slot:
    index: 6
    item: Grenier-Boley B
      type: Person
      first name: Benjamin
      last name: Grenier-Boley
      member of: Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
  slot:
    index: 7
    item: Zettergren A
      type: Person
      first name: Anna
      last name: Zettergren
      member of: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
  slot:
    index: 8
    item: Mishra A
      type: Person
      first name: Aniket
      last name: Mishra
      member of: University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.
  slot:
    index: 9
    item: Ali M
      type: Person
      first name: Muhammad
      last name: Ali
      member of: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
  slot:
    index: 10
    item: Andrade V
      type: Person
      first name: Victor
      last name: Andrade
      member of: Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
  slot:
    index: 11
    item: Bellenguez C
      type: Person
      first name: Céline
      last name: Bellenguez
      member of: Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
  slot:
    index: 12
    item: Kleineidam L
      type: Person
      first name: Luca
      last name: Kleineidam
      member of: Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  slot:
    index: 13
    item: Küçükali F
      type: Person
      first name: Fahri
      last name: Küçükali
      member of: Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  slot:
    index: 14
    item: Sung YJ
      type: Person
      first name: Yun Ju
      last name: Sung
      member of: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
  slot:
    index: 15
    item: Tesí N
      type: Person
      first name: Niccolo
      last name: Tesí
      member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  slot:
    index: 16
    item: Vromen EM
      type: Person
      first name: Ellen M
      last name: Vromen
      member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  slot:
    index: 17
    item: Wightman DP
      type: Person
      first name: Douglas P
      last name: Wightman
      member of: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.
  slot:
    index: 18
    item: Alcolea D
      type: Person
      first name: Daniel
      last name: Alcolea
      member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  slot:
    index: 19
    item: Alegret M
      type: Person
      first name: Montserrat
      last name: Alegret
      member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
  slot:
    index: 20
    item: Alvarez I
      type: Person
      first name: Ignacio
      last name: Alvarez
      member of: Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, Terrassa, Spain.
  slot:
    index: 21
    item: Amouyel P
      type: Person
      first name: Philippe
      last name: Amouyel
      member of: Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
  slot:
    index: 22
    item: Athanasiu L
      type: Person
      first name: Lavinia
      last name: Athanasiu
      member of: NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.
  slot:
    index: 23
    item: Bahrami S
      type: Person
      first name: Shahram
      last name: Bahrami
      member of: NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.
  slot:
    index: 24
    item: Bailly H
      type: Person
      first name: Henri
      last name: Bailly
      member of: Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.
  slot:
    index: 25
    item: Belbin O
      type: Person
      first name: Olivia
      last name: Belbin
      member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  slot:
    index: 26
    item: Bergh S
      type: Person
      first name: Sverre
      last name: Bergh
      member of: The Research-Centre for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Brumunddal, Norway.Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
  slot:
    index: 27
    item: Bertram L
      type: Person
      first name: Lars
      last name: Bertram
      member of: Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
  slot:
    index: 28
    item: Biessels GJ
      type: Person
      first name: Geert Jan
      last name: Biessels
      member of: Department of Neurology, UMC Utrecht Brain Center, Utrecht, The Netherlands.
creator: EADB consortiumGR@ACE study group
created: 2022-9-7T06:00
date last updated: 2025-03-09
issued: 2022-11
dp: 2022 11
created: 2022-9-6T11:15
e ISSN: 1432-0533
has issn l: 0001-6322
issue: 5
has NLM journal title abbreviation: Acta Neuropathol
publication name: Acta neuropathologica
language: eng
has national library of medicine journal id: 0412041
derived from: NLM
starting page: 821
ending page: 842
has place of publication: Germany
has primary subject term: D000544Q000473
has subject term: D016229Q000134
has subject term: D001057Q000235
has subject term: D015415Q000134
has subject term: D018797
has subject term: D006801
has subject term: D010446Q000134
has subject term: D016875Q000134Q000235
source: Acta Neuropathol. 2022-11;144(5):821-842.
volume: 144

Dual peptide-functionalized hydrogels differentially control periodontal cell function and promote tissue regeneration.
pmid: 36067642
abstract: Restoring the tooth-supporting tissues lost during periodontitis is a significant clinical challenge, despite advances in both biomaterial and cell-based approaches. This study investigated poly(ethylene glycol) (PEG) hydrogels functionalized with integrin-binding peptides RGD and GFOGER for controlling periodontal ligament cell (PDLC) activity and promoting periodontal tissue regeneration. Dual presentation of RGD and GFOGER within PEG hydrogels potentiated two key PDLC functions, alkaline phosphatase (ALP) activity and matrix mineralization, over either peptide alone and could be tuned to differentially promote each function. Hydrogel matrix mineralization, fostered by high concentrations of GFOGER together with RGD, identified a PDLC phenotype with accelerated matrix adhesion formation and expression of cementoblast and osteoblast genes. In contrast, maximizing ALP activity through high RGD and low GFOGER levels resulted in minimal hydrogel mineralization, in part, through altered PDLC pyrophosphate regulation. Transplantation of PDLCs in hydrogels optimized for either outcome promoted cementum formation in rat periodontal defects; however, only hydrogels optimized for in vitro mineralization improved new bone formation. Overall, these results highlight the utility of engineered hydrogel systems for controlling PDLC functions and their promise for promoting periodontal tissue regeneration.
rights: Copyright © 2022 Elsevier B.V. All rights reserved.
has PII: S2772-9508(22)00370-3
doi: 10.1016/j.bioadv.2022.213093
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Fraser D
      type: Person
      first name: David
      last name: Fraser
      member of: Translational Biomedical Sciences, University of Rochester Medical Center, Rochester, NY, United States of America; Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, United States of America.
  slot:
    index: 2
    item: Benoit D
      type: Person
      first name: Danielle
      last name: Benoit
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY, United States of America; Department of Chemical Engineering, University of Rochester, Rochester, NY, United States of America; Materials Science Program, University Rochester, Rochester, NY, United States of America; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States of America. Electronic address: danielle.benoit@rochester.edu.
created: 2022-9-7T06:00
date last updated: 2025-03-09
issued: 2022-10
dp: 2022 Oct
created: 2022-9-6T18:21
e ISSN: 2772-9508
has issn l: 2772-9508
has NLM journal title abbreviation: Biomater Adv
publication name: Biomaterials advances
language: eng
has national library of medicine journal id: 9918383886206676
derived from: NLM
pg: 213093
has place of publication: Netherlands
has primary subject term: D011756
has primary subject term: D020100Q000494
has subject term: D000469Q000235
has subject term: D000818
has subject term: D001672
has subject term: D002454
has subject term: D016023
has subject term: D009842
has subject term: D010455
has subject term: D011092
has subject term: D051381
has subject term: D012038
source: Biomater Adv. 2022-10;141():213093.
volume: 141

Poxviruses capture host genes by LINE-1 retrotransposition.
pmid: 36069526
abstract: Horizontal gene transfer (HGT) provides a major source of genetic variation. Many viruses, including poxviruses, encode genes with crucial functions directly gained by gene transfer from hosts. The mechanism of transfer to poxvirus genomes is unknown. Using genome analysis and experimental screens of infected cells, we discovered a central role for Long Interspersed Nuclear Element-1 retrotransposition in HGT to virus genomes. The process recapitulates processed pseudogene generation, but with host messenger RNA directed into virus genomes. Intriguingly, hallmark features of retrotransposition appear to favor virus adaption through rapid duplication of captured host genes on arrival. Our study reveals a previously unrecognized conduit of genetic traffic with fundamental implications for the evolution of many virus classes and their hosts.
rights: © 2022, Fixsen et al.
has PII: 63332
doi: 10.7554/eLife.63332
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Fixsen SM
      type: Person
      first name: Sarah M
      last name: Fixsen
      member of: Department of Human Genetics, University of Utah, Salt Lake City, United States.
  slot:
    index: 2
    item: Cone KR
      type: Person
      first name: Kelsey R
      last name: Cone
      member of: Department of Human Genetics, University of Utah, Salt Lake City, United States.
  slot:
    index: 3
    item: Goldstein SA
      type: Person
      first name: Stephen A
      last name: Goldstein
      member of: Department of Human Genetics, University of Utah, Salt Lake City, United States.
  slot:
    index: 4
    item: Sasani TA
      type: Person
      first name: Thomas A
      last name: Sasani
      member of: Department of Human Genetics, University of Utah, Salt Lake City, United States.
  slot:
    index: 5
    item: Quinlan AR
      type: Person
      first name: Aaron R
      last name: Quinlan
      member of: Department of Human Genetics, University of Utah, Salt Lake City, United States.
  slot:
    index: 6
    item: Rothenburg S
      type: Person
      first name: Stefan
      last name: Rothenburg
      member of: Department of Medical Microbiology and Immunology, University of California, Davis, Davis, United States.
  slot:
    index: 7
    item: Elde NC
      type: Person
      first name: Nels C
      last name: Elde
      member of: Department of Human Genetics, University of Utah, Salt Lake City, United States.Howard Hughes Medical Institute, Chevy Chase, United States.
created: 2022-9-8T06:00
date last updated: 2025-03-09
issued: 2022-09-07
dp: 2022 09 07
created: 2022-9-7T08:53
e ISSN: 2050-084X
has issn l: 2050-084X
has NLM journal title abbreviation: Elife
publication name: eLife
language: eng
has national library of medicine journal id: 101579614
derived from: NLM
has place of publication: England
has primary subject term: D011212Q000235
has primary subject term: D014780Q000235
has subject term: D019143
has subject term: D022761
has subject term: D010802
has subject term: D012333
has subject term: D018626
source: Elife. 2022-09-07;11():.
volume: 11

Type of Infection Is Associated with Prognosis in Acute-on-Chronic Liver Failure: A National Veterans Health Administration Study.
pmid: 36083379
abstract: Acute-on-chronic liver failure (ACLF) is a syndrome in patients with cirrhosis with high short-term mortality. Infection is a frequent precipitant of ACLF; however, it is unclear if prognosis varies by difference infectious sources. To address this knowledge gap, we utilized a large national database of patients with cirrhosis.This was a retrospective cohort study of patients with cirrhosis in the Veterans Health Administration between 2008 and 2016. First ACLF hospitalizations were identified and infections were classified using validated algorithms, categorized as bacteremia, fungal, spontaneous bacterial peritonitis (SBP), pyelonephritis/urinary tract infection, or skin and soft tissue/musculoskeletal infection (SST/MSK). Inverse probability treatment weighing for infection-associated ACLF followed by multivariable logistic regression was used to evaluate the association between infection type and 90-day mortality.A total 22,589 ACLF hospitalizations were included, 3998 (17.7%) of which had ACLF grade 3. Infection was associated with 12,405 (54.9%) of ACLF hospitalizations. In regression models, SBP was associated with a 1.79-fold increased odds of 90-day mortality vs. no infection (95% confidence interval [CI] 1.58-2.02, p < 0.001), whereas SST/MSK infections had a lower relative odds of mortality (odds ratio 0.48, 95% CI 0.42-0.53, p < 0.001). There was a significant interaction between infection category and ACLF grade on the outcome of 90-day mortality (p < 0.001).The impact of infection on short-term mortality in ACLF varies depending on the source of infection. This has relevance for ACLF prognostication and challenges previous notions that bacterial infection invariably worsens prognosis among all patients with ACLF.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07680-9
doi: 10.1007/s10620-022-07680-9
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mahmud N
      type: Person
      first name: Nadim
      last name: Mahmud
      member of: Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. nadim@pennmedicine.upenn.edu.Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. nadim@pennmedicine.upenn.edu.Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. nadim@pennmedicine.upenn.edu.Leonard David Institute of Health Economics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. nadim@pennmedicine.upenn.edu.
  slot:
    index: 2
    item: Reddy KR
      type: Person
      first name: K Rajender
      last name: Reddy
      member of: Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  slot:
    index: 3
    item: Taddei TH
      type: Person
      first name: Tamar H
      last name: Taddei
      member of: Division of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.VA Connecticut Healthcare System, West Haven, CT, USA.
  slot:
    index: 4
    item: Kaplan DE
      type: Person
      first name: David E
      last name: Kaplan
      member of: Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.Department of Medicine, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
created: 2022-9-10T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-9T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1632
ending page: 1640
has place of publication: United States
has primary subject term: D065290Q000175Q000453
has primary subject term: D010538Q000150
has subject term: D006801
has subject term: D012189
has subject term: D058014
has subject term: D008103Q000150
has subject term: D011379
source: Dig Dis Sci. 2023-04;68(4):1632-1640.
volume: 68

Effects of Hepatitis B Virus Infection on Patients with COVID-19: A Meta-Analysis.
pmid: 36085229
abstract: The COVID-19 pandemic has brought new problems to patients infected with hepatitis B virus (HBV).We aim to know the effects of HBV infection on patients with COVID-19.We searched PubMed, Embase, and Web of Science for data and utilized Stata 14.0 software for this meta-analysis with a random-effects model. This paper was conducted in alignment with the preferred reporting items for systematic review and meta-analysis (PRISMA) guideline.In total, 37,696 patients were divided into two groups: 2591 COVID-19 patients infected with HBV in the experimental group and 35,105 COVID-19 patients not infected with HBV in the control group. Our study showed that the in-hospital mortality of the experimental group was significant higher than that of the control group (OR = 2.04, 95% CI 1.49-2.79). We also found that COVID-19 patients infected with HBV were more likely to develop severe disease (OR = 1.90, 95% CI 1.32-2.73) than COVID-19 patients not infected with HBV. Upon measuring alanine aminotransferase (SMD = 0.62, 95% CI 0.25-0.98), aspartate aminotransferase (SMD = 0.60, 95% CI 0.30-0.91), total bilirubin (SMD = 0.45, 95% CI 0.23-0.67), direct bilirubin (SMD = 0.36, 95% CI 0.24-0.47), lactate dehydrogenase (SMD = 0.32, 95% CI 0.18-0.47), we found that HBV infection led to significantly higher laboratory results in COVID-19 patients.COVID-19 patients infected with HBV should receive more attention, and special attention should be given to various liver function indices during treatment.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07687-2
doi: 10.1007/s10620-022-07687-2
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Yu Y
      type: Person
      first name: Yang
      last name: Yu
      member of: Department of Hepatobiliary and Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China.
  slot:
    index: 2
    item: Li X
      type: Person
      first name: Xingzhao
      last name: Li
      member of: Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China.
  slot:
    index: 3
    item: Wan T
      type: Person
      first name: Taihu
      last name: Wan
      member of: Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China. wantaihu@jlu.edu.cn.
created: 2022-9-10T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-9T23:48
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1615
ending page: 1631
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has primary subject term: D006509Q000453
has subject term: D006801
has subject term: D006515
has subject term: D058873
has subject term: D001663
source: Dig Dis Sci. 2023-04;68(4):1615-1631.
volume: 68

Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via IRF5-Mediated Macrophage Polarization.
pmid: 36088512
abstract: Patients with inflammatory bowel disease (IBD) and concurrent depression are predisposed to severer disease activity and a worse prognosis. Macrophage polarization toward the M1 phenotype may contribute to the exacerbation of IBD with comorbid depression. Moreover, interferon regulatory factor 5 (IRF5) is involved in the pathogenesis of IBD. The aim of this study was to explore the role of IRF5 in macrophage polarization in the impact of depression upon colitis.Depressive-like behavior was induced by repeated forced swim stress. Colon length, disease activity index (DAI), colon morphology, histology, ultrastructure of epithelial barrier, lamina propria macrophage polarization, and expression of IRF5 were compared between DSS colitis rats with and without depressive-like behavior. IRF5 shRNA was constructed to affect the rat peritoneal macrophages polarization in vitro. After IRF5 shRNA lentivirus was introduced into colon by enema, the colitis severity, lamina propria macrophage polarization, and TNF-α, IL-1β, and IL-10 of colon tissues were measured.The study found severer colonic inflammation in depressed versus non-depressed DSS-colitis rats. Depressed DSS-colitis rats exhibited smaller subepithelial macrophages size and reduced intracellular granule diversity compared with nondepressed DSS-colitis rats. Increased polarization toward the M1 phenotype, elevated expression of IRF5, and co-expression of IRF5 with CD86 were found in depressed versus nondepressed DSS-colitis rats. Lentivirus-mediated shRNA interference with IRF5 expression switched rat peritoneal macrophage polarization from the M1 to the M2 phenotype, downregulated TNF-α, IL-1β expression to a greater extent in depressed versus nondepressed colitis rats.IRF5-mediated macrophage polarization may likely underlie the deterioration of DSS-induced colitis caused by depression.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07679-2
doi: 10.1007/s10620-022-07679-2
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Liang C
      type: Person
      first name: Chang
      last name: Liang
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 2
    item: Tang Y
      type: Person
      first name: Yu
      last name: Tang
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 3
    item: Gao X
      type: Person
      first name: Xin
      last name: Gao
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 4
    item: Lei N
      type: Person
      first name: Na
      last name: Lei
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 5
    item: Luo Y
      type: Person
      first name: Ying
      last name: Luo
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 6
    item: Chen P
      type: Person
      first name: Pingrun
      last name: Chen
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 7
    item: Duan S
      type: Person
      first name: Shihao
      last name: Duan
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 8
    item: Cao Y
      type: Person
      first name: Yubin
      last name: Cao
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 9
    item: Yang Y
      type: Person
      first name: Yi
      last name: Yang
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China.
  slot:
    index: 10
    item: Zhang Y
      type: Person
      first name: Yan
      last name: Zhang
      member of: Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guoxue Street, Chengdu, Sichuan, China. hxzyan@163.com.
created: 2022-9-11T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-10T23:32
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1269
ending page: 1279
has place of publication: United States
has primary subject term: D003092Q000139Q000473
has primary subject term: D015212Q000473
has subject term: D051381
has subject term: D000818
has subject term: D051379
has subject term: D016264Q000633
has subject term: D014409Q000378
has subject term: D003863
has subject term: D008264Q000378
has subject term: D003106Q000473
has subject term: D034741Q000235
has subject term: D050835Q000235Q000378
has subject term: D008810
has subject term: D004195
source: Dig Dis Sci. 2023-04;68(4):1269-1279.
volume: 68

Prospective comparison of restriction spectrum imaging and non-invasive biomarkers to predict upgrading on active surveillance prostate biopsy.
pmid: 36097168
abstract: Protocol-based active surveillance (AS) biopsies have led to poor compliance. To move to risk-based protocols, more accurate imaging biomarkers are needed to predict upgrading on AS prostate biopsy. We compared restriction spectrum imaging (RSI-MRI) generated signal maps as a biomarker to other available non-invasive biomarkers to predict upgrading or reclassification on an AS biopsy.We prospectively enrolled men on prostate cancer AS undergoing repeat biopsy from January 2016 to June 2019 to obtain an MRI and biomarkers to predict upgrading. Subjects underwent a prostate multiparametric MRI and a short duration, diffusion-weighted enhanced MRI called RSI to generate a restricted signal map along with evaluation of 30 biomarkers (14 clinico-epidemiologic features, 9 molecular biomarkers, and 7 radiologic-associated features). Our primary outcome was upgrading or reclassification on subsequent AS prostate biopsy. Statistical analysis included operating characteristic improvement using AUROC and AUPRC.The individual biomarker with the highest area under the receiver operator characteristic curve (AUC) was RSI-MRI (AUC = 0.84; 95% CI: 0.71-0.96). The best non-imaging biomarker was prostate volume-corrected Prostate Health Index density (PHI, AUC = 0.68; 95% CI: 0.53-0.82). Non-imaging biomarkers had a negligible effect on predicting upgrading at the next biopsy but did improve predictions of overall time to progression in AS.RSI-MRI, PIRADS, and PHI could improve the predictive ability to detect upgrading in AS. The strongest predictor of clinically significant prostate cancer on AS biopsy was RSI-MRI signal output.
rights: © 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
has PII: 10.1038/s41391-022-00591-w
doi: 10.1038/s41391-022-00591-w
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Eng SE
      type: Person
      first name: Stefan E
      last name: Eng
      member of: Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.Institute for Precision Health, UCLA, Los Angeles, CA, USA.Department of Urology, UCLA, Los Angeles, CA, USA.
  slot:
    index: 2
    item: Basasie B
      type: Person
      first name: Benjamin
      last name: Basasie
      member of: Department of Urology, University of Texas Health San Antonio, San Antonio, TX, USA.
  slot:
    index: 3
    item: Lam A
      type: Person
      first name: Alfonso
      last name: Lam
      member of: Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.Institute for Precision Health, UCLA, Los Angeles, CA, USA.Department of Urology, UCLA, Los Angeles, CA, USA.
  slot:
    index: 4
    item: John Semmes O
      type: Person
      first name: O
      last name: John Semmes
      member of: Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA.
  slot:
    index: 5
    item: Troyer DA
      type: Person
      first name: Dean A
      last name: Troyer
      member of: Department of Pathology, Eastern Virginia Medical School, Norfolk, VA, USA.
  slot:
    index: 6
    item: Clarke GD
      type: Person
      first name: Geoffrey D
      last name: Clarke
      member of: Research Imaging Institute, University of Texas Health San Antonio, San Antonio, TX, USA.Department of Radiology, University of Texas Health San Antonio, San Antonio, TX, USA.
  slot:
    index: 7
    item: Sunnapwar AG
      type: Person
      first name: Abhijit G
      last name: Sunnapwar
      member of: Department of Radiology, University of Texas Health San Antonio, San Antonio, TX, USA.
  slot:
    index: 8
    item: Leach RJ
      type: Person
      first name: Robin J
      last name: Leach
      member of: Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
  slot:
    index: 9
    item: Johnson-Pais TL
      type: Person
      first name: Teresa L
      last name: Johnson-Pais
      member of: Department of Urology, University of Texas Health San Antonio, San Antonio, TX, USA.
  slot:
    index: 10
    item: Sokoll LJ
      type: Person
      first name: Lori J
      last name: Sokoll
      member of: Department of Pathology, Division of Clinical Chemistry, Johns Hopkins University, Baltimore, MD, USA.
  slot:
    index: 11
    item: Chan DW
      type: Person
      first name: Daniel W
      last name: Chan
      member of: Department of Pathology, Division of Clinical Chemistry, Johns Hopkins University, Baltimore, MD, USA.
  slot:
    index: 12
    item: Tosoian JJ
      type: Person
      first name: Jeffrey J
      last name: Tosoian
      member of: Department of Urlogy, Vanderbilt University, Nashville, TN, USA.
  slot:
    index: 13
    item: Siddiqui J
      type: Person
      first name: Javed
      last name: Siddiqui
      member of: Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  slot:
    index: 14
    item: Chinnaiyan AM
      type: Person
      first name: Arul M
      last name: Chinnaiyan
      member of: Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  slot:
    index: 15
    item: Thompson IM
      type: Person
      first name: Ian M
      last name: Thompson
      member of: CHRISTUS Santa Rosa Health System, San Antonio, TX, USA.
  slot:
    index: 16
    item: Boutros PC
      type: Person
      first name: Paul C
      last name: Boutros
      member of: Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. PBoutros@mednet.ucla.edu.Institute for Precision Health, UCLA, Los Angeles, CA, USA. PBoutros@mednet.ucla.edu.Department of Urology, UCLA, Los Angeles, CA, USA. PBoutros@mednet.ucla.edu.Department of Human Genetics, UCLA, Los Angeles, CA, USA. PBoutros@mednet.ucla.edu.Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA. PBoutros@mednet.ucla.edu.Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. PBoutros@mednet.ucla.edu.
  slot:
    index: 17
    item: Liss MA
      type: Person
      first name: Michael A
      last name: Liss
      member of: Department of Urology, University of Texas Health San Antonio, San Antonio, TX, USA. liss@uthscsa.edu.Research Imaging Institute, University of Texas Health San Antonio, San Antonio, TX, USA. liss@uthscsa.edu.College of Pharmacy, University of Texas Austin, Austin, TX, USA. liss@uthscsa.edu.Department of Urology, South Texas Veterans Healthcare System, San Antonio, TX, USA. liss@uthscsa.edu.
created: 2022-9-14T06:00
date last updated: 2025-03-09
issued: 2024-03
dp: 2024 Mar
created: 2022-9-13T00:05
e ISSN: 1476-5608
has issn l: 1365-7852
issue: 1
has NLM journal title abbreviation: Prostate Cancer Prostatic Dis
publication name: Prostate cancer and prostatic diseases
language: eng
has national library of medicine journal id: 9815755
derived from: NLM
starting page: 65
ending page: 72
has place of publication: England
has primary subject term: D011467Q000000981Q000473
has primary subject term: D011471Q000000981Q000473
has subject term: D008297
has subject term: D006801
has subject term: D057832Q000379
has subject term: D060787
has subject term: D001706
has subject term: D008279Q000379
has subject term: D015415
has subject term: D061705Q000379
source: Prostate Cancer Prostatic Dis. 2024-03;27(1):65-72.
volume: 27

NEDD8-Activating Enzyme Inhibitor MLN4924 Inhibits Both the Tumor Stroma and Angiogenesis in Pancreatic Cancer via Gli1 and REDD1.
pmid: 36098876
abstract: Pancreatic cancer is characterized by a dense desmoplasia stroma, which hinders efficient drug delivery and plays a critical role in tumor progression and metastasis. MLN4924 is a first-in-class NEDD8-activating enzyme inhibitor that exhibits anti-tumor activities toward pancreatic cancer, and given the comprehensive effects that MLN4924 could have, we ask what impact MLN4924 would have on the stroma of pancreatic cancer and its underlying mechanisms.Primary pancreatic stellate cells (PSCs) and human HMEC-1 cells were treated with MLN4924 in vitro. The proliferation and extracellular matrix protein levels of PSCs were tested, and their relationship with transcription factor Gli1 in PSCs was investigated. The angiogenic phenotypes of HMEC-1 cells were evaluated using capillary-like tube formation assay, and their relationship with REDD1 in HMEC-1 cells was investigated.In this study, we found that MLN4924 inhibited the proliferation of pancreatic stellate cells and their secretion of collagen and CXCL-1, and the collagen secretion inhibiting effect of MLN4924 was related with transcription factor Gli1. MLN4924 inhibited multiple angiogenic phenotypes of HMEC-1 cells, and mTOR agonist partially relieved the inhibition of MLN4924 on HEMCs. MLN4924 increased the expression of REDD1 and REDD1 knockdown promoted the angiogenic phenotypes of HMEC-1 cells.Our study suggests that MLN4924 inhibits both the tumor stroma and angiogenesis in pancreatic cancer, and the inhibition effect is related with Gli1 in pancreatic stellate cells and REDD1 in vascular endothelial cells, respectively.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07671-w
doi: 10.1007/s10620-022-07671-w
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Mao W
      type: Person
      first name: Weilin
      last name: Mao
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
  slot:
    index: 2
    item: Zhang L
      type: Person
      first name: Lei
      last name: Zhang
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
  slot:
    index: 3
    item: Rong Y
      type: Person
      first name: Yefei
      last name: Rong
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
  slot:
    index: 4
    item: Kuang T
      type: Person
      first name: Tiantao
      last name: Kuang
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
  slot:
    index: 5
    item: Wang D
      type: Person
      first name: Dansong
      last name: Wang
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
  slot:
    index: 6
    item: Xu X
      type: Person
      first name: Xuefeng
      last name: Xu
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
  slot:
    index: 7
    item: Lou W
      type: Person
      first name: Wenhui
      last name: Lou
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. lou.wenhui@zs-hospital.sh.cn.
  slot:
    index: 8
    item: Li J
      type: Person
      first name: Jianang
      last name: Li
      member of: Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. li.jian_ang@zs-hospital.sh.cn.
created: 2022-9-14T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-13T11:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1351
ending page: 1363
has place of publication: United States
has primary subject term: D042783Q000473
has primary subject term: D010190Q000188Q000473
has subject term: D006801
has subject term: D000071676Q000235
has subject term: D014157Q000235
has subject term: D004791Q000494
has subject term: D045744
has subject term: D017209
has subject term: http://id.nlm.nih.gov/mesh/D000075687
source: Dig Dis Sci. 2023-04;68(4):1351-1363.
volume: 68

Motorized Spiral Enteroscopy Is Effective in Patients with Prior Abdominal Surgery.
pmid: 36104534
abstract: Motorized Spiral Enteroscopy (MSE) reduces procedure time and increases insertion depth into the small bowel; however, there is scarce evidence on factors affecting MSE efficacy.To evaluate diagnostic yield and adverse events of MSE including patients with prior major abdominal surgery.A prospective observational study was conducted on patients undergoing MSE from June 2019 to December 2021. Demographic characteristics, procedure time, depth of maximum insertion (DMI), technical success, diagnostic yield, and adverse events were collected.Seventy-four anterograde (54.4%) and 62 retrograde (45.6%) enteroscopies were performed in 117 patients (64 males, median age 67 years). Fifty patients (42.7%) had prior major abdominal surgery. Technical success was 91.9% for anterograde and 90.3% for retrograde route. Diagnostic yield was 71.6% and 61.3%, respectively. The median DMI was 415 cm (264-585) for anterograde and 120 cm (37-225) for retrograde enteroscopy. In patients with prior major abdominal surgery, MSE showed significantly longer small bowel insertion time (38 vs 29 min, p = 0.004), with similar diagnostic yield (61 vs 71.4%, p = 0.201) and DMI (315 vs 204 cm, p = 0.226). The overall adverse event rate was 10.3% (SAE 1.5%), with no differences related to prior abdominal surgery (p = 0.598). Patients with prior surgeries directly involving the gastrointestinal tract showed lower DMI (189 vs 374 cm, p = 0.019) with equal exploration time (37.5 vs 38 min, p = 0.642) compared to those with other abdominal surgeries.MSE is effective and safe in patients with major abdominal surgery, although longer procedure times were observed. A lower depth of insertion was detected in patients with gastrointestinal surgery.
rights: © 2022. The Author(s).
has PII: 10.1007/s10620-022-07688-1
doi: 10.1007/s10620-022-07688-1
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Giordano A
      type: Person
      first name: Antonio
      last name: Giordano
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  slot:
    index: 2
    item: Casanova G
      type: Person
      first name: Gherzon
      last name: Casanova
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.
  slot:
    index: 3
    item: Escapa M
      type: Person
      first name: Miriam
      last name: Escapa
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.
  slot:
    index: 4
    item: Fernández-Esparrach G
      type: Person
      first name: Gloria
      last name: Fernández-Esparrach
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  slot:
    index: 5
    item: Ginès À
      type: Person
      first name: Àngels
      last name: Ginès
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  slot:
    index: 6
    item: Sendino O
      type: Person
      first name: Oriol
      last name: Sendino
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
  slot:
    index: 7
    item: Araujo IK
      type: Person
      first name: Isis K
      last name: Araujo
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
  slot:
    index: 8
    item: Cárdenas A
      type: Person
      first name: Andrés
      last name: Cárdenas
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.Faculty of Medicine, University of Barcelona, Barcelona, Spain.GI & Liver Transplant Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Barcelona, Spain.
  slot:
    index: 9
    item: Córdova H
      type: Person
      first name: Henry
      last name: Córdova
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
  slot:
    index: 10
    item: Martínez-Ocon J
      type: Person
      first name: Julia
      last name: Martínez-Ocon
      member of: Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  slot:
    index: 11
    item: Martínez-Palli G
      type: Person
      first name: Graciela
      last name: Martínez-Palli
      member of: Faculty of Medicine, University of Barcelona, Barcelona, Spain.Anesthesiology Department, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
  slot:
    index: 12
    item: Balaguer F
      type: Person
      first name: Francesc
      last name: Balaguer
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  slot:
    index: 13
    item: Llach J
      type: Person
      first name: Josep
      last name: Llach
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  slot:
    index: 14
    item: Ricart E
      type: Person
      first name: Elena
      last name: Ricart
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  slot:
    index: 15
    item: González-Suárez B
      type: Person
      first name: Begoña
      last name: González-Suárez
      member of: Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic of Barcelona, Barcelona, Spain. bgonzals@clinic.cat.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. bgonzals@clinic.cat.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain. bgonzals@clinic.cat.Faculty of Medicine, University of Barcelona, Barcelona, Spain. bgonzals@clinic.cat.
created: 2022-9-15T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-14T23:32
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1447
ending page: 1454
has place of publication: United States
has primary subject term: D007410Q000175
has primary subject term: D010535
has subject term: D008297
has subject term: D006801
has subject term: D000368
has subject term: D016099Q000009Q000379
has subject term: D011446
has subject term: D007421Q000601
has subject term: D058582Q000379
source: Dig Dis Sci. 2023-04;68(4):1447-1454.
volume: 68

Stratification Based on Risk Factors at Diagnosis Could Predict Progression in Patients with Pancreatic Cysts.
pmid: 36125596
abstract: Predicting the risk of malignant transformation in pancreatic cyst patients is challenging.We retrospectively investigated the risk factors for malignant transformation in pancreatic cyst patients.Patients with pancreatic cysts diagnosed using imaging tests were followed from November 2008 to December 2021. A significant change was defined as the additional development of high-risk stigmata (HRS), worrisome features (WFs), or pancreatic cancer during monitoring.In total, 479 patients were analyzed, with a median observation period of 50 months. Forty-four patients (9.2%) showed significant changes, and eight (1.7%) developed pancreatic cancer. The univariate analysis showed that the cyst diameter at diagnosis (≥ 14 mm), main pancreatic duct (MPD) diameter at diagnosis (≥ 3 mm), presence of multilocular cysts, and an inconsistent MPD caliber were significant predictive factors for a significant change. One point was assigned for each significant factor. We grouped the patients into three groups: the low-risk group (total score 0), medium-risk group (score 1-2), and high-risk group (score 3-4). The high-risk group had a higher risk of a significant change than the medium- and low-risk groups (age-adjusted HRs for the medium-risk and high-risk groups were 3.0 and 5.2 compared with the low-risk group).Stratification based on risk factors may help predict the development of significant changes in pancreatic cyst patients.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07699-y
doi: 10.1007/s10620-022-07699-y
creator: OrderedList
  length: 19
  slot:
    index: 1
    item: Sugio R
      type: Person
      first name: Ryo
      last name: Sugio
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 2
    item: Nishida T
      type: Person
      first name: Tsutomu
      last name: Nishida
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan. tnishida@gh.med.osaka-u.ac.jp.
  slot:
    index: 3
    item: Matsumoto K
      type: Person
      first name: Kengo
      last name: Matsumoto
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 4
    item: Kawamura K
      type: Person
      first name: Kosuke
      last name: Kawamura
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 5
    item: Park M
      type: Person
      first name: Miyoung
      last name: Park
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 6
    item: Hamabe T
      type: Person
      first name: Tomoya
      last name: Hamabe
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 7
    item: Hosokawa K
      type: Person
      first name: Kana
      last name: Hosokawa
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 8
    item: Kuriki S
      type: Person
      first name: Shinji
      last name: Kuriki
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 9
    item: Chang LS
      type: Person
      first name: Li-Sa
      last name: Chang
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 10
    item: Fujii Y
      type: Person
      first name: Yoshifumi
      last name: Fujii
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 11
    item: Osugi N
      type: Person
      first name: Naoto
      last name: Osugi
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 12
    item: Sugimoto A
      type: Person
      first name: Aya
      last name: Sugimoto
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 13
    item: Mukai K
      type: Person
      first name: Kaori
      last name: Mukai
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 14
    item: Nakamatsu D
      type: Person
      first name: Dai
      last name: Nakamatsu
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 15
    item: Hayashi S
      type: Person
      first name: Shiro
      last name: Hayashi
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 16
    item: Yamamoto M
      type: Person
      first name: Masashi
      last name: Yamamoto
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 17
    item: Nakajima S
      type: Person
      first name: Sachiko
      last name: Nakajima
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 18
    item: Fukui K
      type: Person
      first name: Koji
      last name: Fukui
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
  slot:
    index: 19
    item: Inada M
      type: Person
      first name: Masami
      last name: Inada
      member of: Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka, 560-8565, Japan.
created: 2022-9-21T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-20T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1511
ending page: 1518
has place of publication: United States
has primary subject term: D021441Q000473
has primary subject term: D010190Q000000981Q000473
has primary subject term: D010181Q000000981Q000473
has subject term: D006801
has subject term: D012189
has subject term: D012307
has subject term: D010183Q000000981Q000473
source: Dig Dis Sci. 2023-04;68(4):1511-1518.
volume: 68

Band Ligation Can Be Used to Treat Barrett's Esophagus and Concurrent Esophageal Varices: A Case Series.
pmid: 36131048
abstract: Patients with Barrett's esophagus (BE) and esophageal varices present a unique management dilemma. Endoscopic ablation and endoscopic resection are not suitable treatment options due to bleeding risk. Data are limited on successful eradication of BE and esophageal varices utilizing band ligation.To assess the outcomes of patients with BE and esophageal varices treated with banding.Retrospective analysis of patients with BE and esophageal varices who were treated with band ligation.A total of eight patients were included in the case series. In all eight cases, BE and esophageal varices were successfully treated with band ligation alone. There were no bleeding, perforation or infectious complications in any patients undergoing banding for treatment of BE. Four patients had biopsy-proven dysplasia prior to treatment with band ligation. After band ligation, the 2 of 4 dysplastic cases that had repeat biopsies showed histologic resolution of the dysplasia. All patients who received banding for BE were followed at least yearly except for one patient lost to follow up. No interval esophageal cancers were reported in any patients with BE that were banded.Band ligation was used to treat BE pathology in eight patients with esophageal varices. Treatment of dysplasia through this method yielded negative biopsies both for dysplasia and BE on repeat endoscopy. This case series highlights the value of utilizing band ligation to address the management dilemma of BE in the context of esophageal varices.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07696-1
doi: 10.1007/s10620-022-07696-1
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hartgerink C
      type: Person
      first name: Colin
      last name: Hartgerink
      member of: Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI, 48201, USA. colin.hartgerink@med.wayne.edu.
  slot:
    index: 2
    item: Nimri FM
      type: Person
      first name: Faisal M
      last name: Nimri
      member of: Department of Gastroenterology, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
  slot:
    index: 3
    item: Zuchelli T
      type: Person
      first name: Tobias
      last name: Zuchelli
      member of: Department of Gastroenterology, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
  slot:
    index: 4
    item: Jafri SM
      type: Person
      first name: Syed-Mohammed
      last name: Jafri
      member of: Department of Gastroenterology, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
  slot:
    index: 5
    item: Piraka C
      type: Person
      first name: Cyrus
      last name: Piraka
      member of: Department of Gastroenterology, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
created: 2022-9-22T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-21T23:24
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1381
ending page: 1385
has place of publication: United States
has primary subject term: D001471Q000150Q000601Q000473
has primary subject term: D004932Q000601Q000150
has primary subject term: D004938Q000150Q000601Q000473
has subject term: D006801
has subject term: D012189
has subject term: D004945Q000379
has subject term: D008026
has subject term: D006965Q000150
source: Dig Dis Sci. 2023-04;68(4):1381-1385.
volume: 68

Similar Time Trends of Hodgkin Lymphoma, Multiple Sclerosis, and Inflammatory Bowel Disease.
pmid: 36168073
abstract: The Epstein-Barr virus (EBV) plays a role in the causation of Hodgkin lymphoma (HL) and multiple sclerosis (MS). A previous study showed that the time trends of mortality from Crohn's disease (CD) and MS shared striking similarities. It was hypothesized that such similarities would also involve the time trends of ulcerative colitis and HL.To compare the time trends of CD and UC with those of HL and MS in 6 different countries.Using the vital statistics of England, Canada, Netherlands, Scotland, Switzerland, and United States from 1951 to 2020, the time trends of mortality from these 4 diseases were compared. The time-dependent changes of death rates were subjected to a birth-cohort analysis.Similar trends were observed in all 6 countries. UC mortality rose among generations born during the nineteenth century and decreased among all generations born subsequently during the twentieth century. CD mortality was similarly characterized by a birth-cohort pattern with a rise and fall that were shifted by 20-30 years towards more recent generations when compared to UC. The birth-cohort pattern of UC was matched by a similar pattern of HL, whereas the birth-cohort pattern of CD was matched by a similar pattern of MS.The similarities in the ubiquitous birth-cohort patterns of UC, CD, HL, and MS suggest that these 4 diseases share a common environmental risk factor. Such risk factor may be linked to EBV or its acquisition during an early period of a patient's lifetime.
rights: © 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
has PII: 10.1007/s10620-022-07705-3
doi: 10.1007/s10620-022-07705-3
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Sonnenberg A
      type: Person
      first name: Amnon
      last name: Sonnenberg
      member of: Section of Gastroenterology, Portland VA Medical Center, P3-GI, Portland, OR, 97239, USA. sonnenbe@ohsu.edu.Division of Gastroenterology and Hepatology, Oregon Health & Science University, Portland, OR, USA. sonnenbe@ohsu.edu.
created: 2022-9-29T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-28T00:12
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1455
ending page: 1463
has place of publication: United States
has primary subject term: D020031Q000453
has primary subject term: D006689Q000453Q000150Q000473
has primary subject term: D009103Q000453Q000150
has primary subject term: D015212Q000150
has primary subject term: D003093Q000453
has primary subject term: D003424Q000150
has subject term: D006801
has subject term: D004854
source: Dig Dis Sci. 2023-04;68(4):1455-1463.
volume: 68

COVID-19 Pandemic Had Minimal Impact on Colonoscopy Completion After Colorectal Cancer Red Flag Sign or Symptoms in US Veterans.
pmid: 36169748
abstract: Delays in colonoscopy work-up for red flag signs or symptoms of colorectal cancer (CRC) during the COVID-19 pandemic are not well characterized.To examine colonoscopy uptake and time to colonoscopy after red flag diagnosis, before and during the COVID-19 pandemic.Cohort study of adults ages 50-75 with iron deficiency anemia (IDA), hematochezia, or abnormal stool blood test receiving Veterans Health Administration (VHA) care from April 2019 to December 2020. Index date was first red flag diagnosis date, categorized into pre (April-December 2019) and intra (April-December 2020) policy implementation prioritizing diagnostic procedures, allowing for a 3-month washout (January-March 2020) period. Outcomes were colonoscopy completion and time to colonoscopy pre- vs. intra-COVID-19, examined using multivariable Cox models with hazard ratios (aHRs) and 95% confidence intervals (CIs).There were 52,539 adults with red flag signs or symptoms (pre-COVID: 25,154; washout: 7527; intra-COVID: 19,858). Proportion completing colonoscopy was similar pre- vs. intra-COVID-19 (27.0% vs. 26.5%; p = 0.24). Median time to colonoscopy among colonoscopy completers was similar for pre- vs. intra-COVID-19 (46 vs. 42 days), but longer for individuals with IDA (60 vs. 49 days). There was no association between time period and colonoscopy completion (aHR: 0.99, 95% CI 0.95-1.03).Colonoscopy work-up of CRC red flag signs and symptoms was not delayed within VHA during the COVID-19 pandemic, possibly due to VHA policies supporting prioritization and completion. Further work is needed to understand how COVID-19 policies on screening and surveillance impact CRC-related outcomes, and how to optimize colonoscopy completion after a red flag diagnosis.
rights: © 2022. The Author(s).
has PII: 10.1007/s10620-022-07685-4
doi: 10.1007/s10620-022-07685-4
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Demb J
      type: Person
      first name: Joshua
      last name: Demb
      member of: Jennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA. jdemb@health.ucsd.edu.Division of Gastroenterology, Department of Internal Medicine, University of California, San Diego, La Jolla, CA, USA. jdemb@health.ucsd.edu.University of California, San Diego, 3350 La Jolla Village Dr MC 151B, San Diego, CA, 92161, USA. jdemb@health.ucsd.edu.
  slot:
    index: 2
    item: Liu L
      type: Person
      first name: Lin
      last name: Liu
      member of: Jennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.Moores Cancer Center, University of California, La Jolla, CA, USA.
  slot:
    index: 3
    item: Bustamante R
      type: Person
      first name: Ranier
      last name: Bustamante
      member of: Jennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.Moores Cancer Center, University of California, La Jolla, CA, USA.
  slot:
    index: 4
    item: Dominitz JA
      type: Person
      first name: Jason A
      last name: Dominitz
      member of: National Gastroenterology and Hepatology Program, Veterans Health Administration, Washington, DC, USA.Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA, USA.
  slot:
    index: 5
    item: Earles A
      type: Person
      first name: Ashley
      last name: Earles
      member of: Jennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.Veterans Medical Research Foundation, San Diego, CA, USA.
  slot:
    index: 6
    item: Shah SC
      type: Person
      first name: Shailja C
      last name: Shah
      member of: Jennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.Division of Gastroenterology, Department of Internal Medicine, University of California, San Diego, La Jolla, CA, USA.Moores Cancer Center, University of California, La Jolla, CA, USA.
  slot:
    index: 7
    item: Gawron AJ
      type: Person
      first name: Andrew J
      last name: Gawron
      member of: VA Salt Lake City Health Care System, Salt Lake City, UT, USA.Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
  slot:
    index: 8
    item: Martinez ME
      type: Person
      first name: Maria Elena
      last name: Martinez
      member of: Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA, USA.Moores Cancer Center, University of California, La Jolla, CA, USA.
  slot:
    index: 9
    item: Gupta S
      type: Person
      first name: Samir
      last name: Gupta
      member of: Jennifer Moreno VA San Diego Healthcare System, San Diego, CA, USA.Division of Gastroenterology, Department of Internal Medicine, University of California, San Diego, La Jolla, CA, USA.Moores Cancer Center, University of California, La Jolla, CA, USA.
created: 2022-9-29T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-28T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1208
ending page: 1217
has place of publication: United States
has primary subject term: D015179Q000175Q000453Q000517
has primary subject term: D014728
has primary subject term: D000086382Q000453
has subject term: D000328
has subject term: D006801
has subject term: D008875
has subject term: D000368
has subject term: D015331
has subject term: D058873
has subject term: D007501
has subject term: D003113
has subject term: D055088Q000379
source: Dig Dis Sci. 2023-04;68(4):1208-1217.
volume: 68

Electronic Health Record Work Demands for Gastroenterology and Hepatology Providers: A Prospective Use Analysis and Survey Study.
pmid: 36169749
abstract: There is a paucity of research on the use of the electronic health record (EHR) by gastroenterology and hepatology providers and its effect on work-life balance. Our aim was to study the after-hour EHR work completed among providers within a multispecialty academic practice.Time spent completing EHR tasks during evening hours (7p-7a) and days off was prospectively recorded for 35 providers over six consecutive months at a single center. Type and time of EHR tasks completed were compared based on subspecialty, academic degree, academic track category, identified gender, and number of weekly assigned clinical days worked. Prior to the data collection, providers filled out a survey regarding EHR use, work hours, and work-life balance.All providers used EHR during evening hours and during days off. The total mean after-hours time spent completing EHR tasks was 18.4 m (± 13.0) per day and 45.0 m (± 25.8) during days off. There was significant variation in the daily mean after-hours time spent completing EHR tasks among subspecialties, range 45.3 m (± 27.1) (advanced endoscopy)-28.7 m (± 22.7) (hepatology), and among providers who work clinically > 7.5 days per week versus those who do not, 42.1 m (± 25.7) vs 30.0 m (± 14.0). The most common after-hours EHR task was note completion. 83% providers reported being unable to complete EHR tasks during allotted workday time and 87% report that EHR tasks interfered with family life; 74% with social life.Gastroenterology and hepatology providers spend a significant amount of after-hour time completing EHR tasks which is perceived to interfere with family/social life.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07691-6
doi: 10.1007/s10620-022-07691-6
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Benson M
      type: Person
      first name: Mark
      last name: Benson
      member of: University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue H6/516, Madison, WI, 53792, USA. mb4@medicine.wisc.edu.
  slot:
    index: 2
    item: Gopal D
      type: Person
      first name: Deepak
      last name: Gopal
      member of: University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue H6/516, Madison, WI, 53792, USA.
  slot:
    index: 3
    item: Pfau P
      type: Person
      first name: Patrick
      last name: Pfau
      member of: University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue H6/516, Madison, WI, 53792, USA.
created: 2022-9-29T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-28T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1218
ending page: 1225
has place of publication: United States
has primary subject term: D057286
has primary subject term: D005762
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000072358
has subject term: D013997
source: Dig Dis Sci. 2023-04;68(4):1218-1225.
volume: 68

Prepandemic Prevalence Estimates of Fatty Liver Disease and Fibrosis Defined by Liver Elastography in the United States.
pmid: 36173583
abstract: Fatty liver disease is a growing public health burden. We estimated prepandemic fatty liver disease prevalence determined by transient elastography-assessed hepatic steatosis and fibrosis, and examined associations with lifestyle and other factors in a United States population sample.Liver stiffness and controlled attenuation parameter (CAP) were assessed on 7923 non-Hispanic white, non-Hispanic black, non-Hispanic Asian, and Hispanic men and women aged 20 years and over in the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 prepandemic data.The prevalence of fatty liver disease (CAP > 300 dB/m) was 28.8% and of fibrosis (liver stiffness > 8 kPa) was 10.4%. Only 7.2% of participants with fatty liver disease and 10.9% with fibrosis reported being told by a health care provider that they had liver disease. In addition to known risk factors such as metabolic factors and ALT, persons with fatty liver disease were less likely to meet physical activity guidelines, more likely to be sedentary for ≥ 12 h a day, and reported a less healthy diet. Persons with fibrosis were less likely to have a college degree and reported a less healthy diet.In the U.S. population, most persons with fatty liver disease are unaware of their condition. Physical activity and dietary modifications might reduce the fatty liver disease burden. There is an urgent need for fatty liver disease management in high-risk individuals using transient elastography or other noninvasive methods to intervene in disease progression.
rights: © 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
has PII: 10.1007/s10620-022-07707-1
doi: 10.1007/s10620-022-07707-1
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Unalp-Arida A
      type: Person
      first name: Aynur
      last name: Unalp-Arida
      member of: Department of Health and Human Services, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Two Democracy Plaza, Room 6009, 6707 Democracy Blvd., Bethesda, MD, 20892-5458, USA.
  slot:
    index: 2
    item: Ruhl CE
      type: Person
      first name: Constance E
      last name: Ruhl
      member of: Social & Scientific Systems, Inc., a DLH Holdings Corp Company, 8757 Georgia Avenue, 12th Floor, Silver Spring, MD, 20910, USA. constance.ruhl@dlhcorp.com.
created: 2022-9-30T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-29T11:20
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1237
ending page: 1252
has place of publication: United States
has primary subject term: D054459
has primary subject term: D065626Q000000981Q000453Q000150
has subject term: D008297
has subject term: D006801
has subject term: D005260
has subject term: D014481Q000453
has subject term: D009749
has subject term: D008103Q000000981Q000453
has subject term: D015995
has subject term: D008099Q000473
source: Dig Dis Sci. 2023-04;68(4):1237-1252.
volume: 68

Age- and Gender-Based Differences in Anorectal Function, Gastrointestinal Symptoms, and Constipation-Specific Quality of Life in Patients with Chronic Constipation.
pmid: 36173584
abstract: The effect of age and gender differences on anorectal function, symptoms severity, and quality of life (QoL) in patients with chronic constipation (CC) is not well studied. This study examines the impact of age and gender on anorectal function testing (AFT) characteristics, symptoms burden, and QoL in patients with CC.This is a retrospective analysis of prospectively collected data from 2550 adults with CC who completed AFT. Collected data include demographics, sphincter response to simulated defecation during anorectal manometry (ARM), balloon expulsion testing (BET), and validated surveys assessing constipation symptoms and QoL. DD was defined as both the inability to relax the anal sphincter during simulated defecation and an abnormal BET.2550 subjects were included in the analysis (mean age = 48.6 years). Most patients were female (81.6%) and Caucasian (82%). 73% were < 60 years old (mean = 41) vs. 27% ≥ 60 years old (mean = 69). The prevalence of impaired anal sphincter relaxation on ARM, abnormal BET, and DD in patients with CC was 48%, 42.1%, and 22.9%, respectively. Patients who were older and male were significantly more frequently diagnosed with DD and more frequently had impaired anal sphincter relaxation on ARM, compared to patients who were younger and female (p < 0.05). Conversely, CC patients who were younger and female reported greater constipation symptoms severity and more impaired QoL (p ≤ 0.004).Among patients with CC referred for anorectal function testing, men and those older than 60 are more likely to have dyssynergic defecation, but women and patients younger than 60 experience worse constipation symptoms and QoL.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07709-z
doi: 10.1007/s10620-022-07709-z
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Nojkov B
      type: Person
      first name: Borko
      last name: Nojkov
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA. bnojkov@med.umich.edu.
  slot:
    index: 2
    item: Baker JR
      type: Person
      first name: Jason R
      last name: Baker
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 3
    item: Chey WD
      type: Person
      first name: William D
      last name: Chey
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 4
    item: Saad R
      type: Person
      first name: Richard
      last name: Saad
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 5
    item: Watts L
      type: Person
      first name: Lydia
      last name: Watts
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 6
    item: Armstrong M
      type: Person
      first name: Moira
      last name: Armstrong
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 7
    item: Collins K
      type: Person
      first name: Kristen
      last name: Collins
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 8
    item: Ezell G
      type: Person
      first name: Gabrielle
      last name: Ezell
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 9
    item: Phillips C
      type: Person
      first name: Cari
      last name: Phillips
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
  slot:
    index: 10
    item: Menees S
      type: Person
      first name: Stacy
      last name: Menees
      member of: Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr. SPC 5362, Ann Arbor, MI, 48109, USA.
created: 2022-9-30T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-29T11:20
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1403
ending page: 1410
has place of publication: United States
has primary subject term: D011788
has primary subject term: D003672Q000502
has subject term: D000328
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D008875
has subject term: D012189
has subject term: D012737
has subject term: D008365
has subject term: D003248Q000175Q000453
has subject term: D001003
has subject term: D011795
has subject term: D012007
source: Dig Dis Sci. 2023-04;68(4):1403-1410.
volume: 68

Efficacy and Safety of Bezafibrate Alone or in Combination with Ursodeoxycholic Acid in Primary Biliary Cholangitis: Systematic Review and Meta-Analysis.
pmid: 36180756
abstract: Bezafibrate (BZF) alone or in combination with ursodeoxycholic acid (UDCA) has been used to slow disease progression in patients with primary biliary cholangitis (PBC). We performed a systematic review and meta-analysis to assess the efficacy and harms of BZF monotherapy or combination therapy.We performed a systematic search of PubMed, EMBASE, Cochrane Library, Scopus, ClinicalTrials.gov, and WHO ICTRP from inception until January 2020, for randomized controlled clinical trials assessing BZF + UDCA versus UDCA monotherapy or BZF monotherapy versus UDCA monotherapy in PBC patients. Additionally, we systematically evaluated data on harms using seven observational studies. Pooled effect estimates were calculated for the outcomes of interest. The certainty of evidence was assessed using GRADE (Grading of Recommendations Assessment, Development and Evaluation).We identified 7 randomized controlled trials with a total of 279 participants. Comparing BZF + UDCA to UDCA alone, a clinically significant improvement was observed in serum ALP with a mean difference (MD) of - 159.04 U/L (95% CI - 186.45 to - 131.62) and a reduction in gamma-glutamyltransferase (GGT) (MD - 106.94 IU/L; 95% CI - 151.99 to - 61.89), but not in total bilirubin (TB) or IgM levels. A statistically significant reduction in ALP levels was also noticed with BZF monotherapy compared to UDCA monotherapy. The effect of BZF + UDCA versus UDCA on mortality remains unclear. Across 5 observational studies including 106 patients, one death was reported due to advanced liver disease in an incomplete responder getting treatment with BZF + UDCA. Analysis of observational studies demonstrated improvement in pruritus intensity with BZF.Use of BZF alone or in combination with UDCA improved liver biochemistries in patients with PBC, but its effect on mortality, liver-related complications or quality of life remains unknown.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07704-4
doi: 10.1007/s10620-022-07704-4
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Khakoo NS
      type: Person
      first name: Nidah Shabbir
      last name: Khakoo
      member of: Department of Internal Medicine, University of Miami School of Medicine, Miami, FL, USA.
  slot:
    index: 2
    item: Sultan S
      type: Person
      first name: Shahnaz
      last name: Sultan
      member of: Department of Gastroenterology and Hepatology, University of Minnesota and Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA.
  slot:
    index: 3
    item: Reynolds JM
      type: Person
      first name: John M
      last name: Reynolds
      member of: Department of Health Informatics, Calder Memorial Library, University of Miami Miller School of Medicine, Miami, FL, USA.
  slot:
    index: 4
    item: Levy C
      type: Person
      first name: Cynthia
      last name: Levy
      member of: Division of Digestive Health and Liver Diseases, University of Miami School of Medicine, 1500 NW 12th Avenue, Suite 1101, Miami, FL, 33136, USA. clevy@med.miami.edu.Schiff Center for Liver Diseases, University of Miami, Miami, FL, USA. clevy@med.miami.edu.
created: 2022-10-1T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-9-30T23:40
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1559
ending page: 1573
has place of publication: United States
has primary subject term: D014580Q000009
has primary subject term: D008105Q000175Q000188
has subject term: D006801
has subject term: D001629Q000009
has subject term: D011788
has subject term: D004359
has subject term: D002756Q000009
source: Dig Dis Sci. 2023-04;68(4):1559-1573.
volume: 68

Cannabidiol attenuates generalized tonic-clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain.
pmid: 36195689
abstract: Cannabidiol (CBD) has been of rapidly growing interest in the epilepsy research field due to its antiseizure properties in preclinical models and patients with pharmacoresistant epilepsy. However, little is known about CBD effects in genetic models of epilepsies. Here we assessed CBD dose-response effects in the Genetically Epilepsy Prone Rats (GEPR-3) strain, which exhibits two types of epileptic seizures, brainstem-dependent generalized tonic-clonic seizures and limbic seizures.GEPR-3 s were submitted to the audiogenic seizure (AGS) protocol. Acute AGS are brainstem-dependent generalized tonic-clonic, while repeated AGS (or audiogenic kindling, AK), an epileptogenic process, leads to increased AGS severity and limbic seizure expression. Therefore, two different dose-response studies were performed, one for generalized tonic-clonic seizures and the other for limbic seizures. CBD time-course effects were assessed 2, 4, and 6 h after drug injection. GEPR-3 s were submitted to within-subject tests, receiving intraperitoneal injections of CBD (1, 10, 50, 100 mg/kg/ml) and vehicle.CBD dose-dependently attenuated generalized tonic-clonic seizures in GEPR-3 s; CBD 50 and 100 mg/kg reduced brainstem-dependent seizure severity and duration. In fully kindled GEPR-3 s, CBD 10 mg/kg reduced limbic seizure severity and suppressed limbic seizure expression in 75% of animals.CBD was effective against brainstem and limbic seizures in the GEPR-3 s. These results support the use of CBD treatment for epilepsies by adding new information about the pharmacological efficacy of CBD in suppressing inherited seizure susceptibility in the GEPR-3 s.
rights: © 2022. The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences.
has PII: 10.1007/s43440-022-00416-6
doi: 10.1007/s43440-022-00416-6
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lazarini-Lopes W
      type: Person
      first name: Willian
      last name: Lazarini-Lopes
      member of: Department of Pharmacology and Physiology, Georgetown University, New Research Bldg., W209B, 3970 Reservoir Road NW, Washington, DC, 20007, USA.Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
  slot:
    index: 2
    item: Campos-Rodriguez C
      type: Person
      first name: Carolina
      last name: Campos-Rodriguez
      member of: Department of Pharmacology and Physiology, Georgetown University, New Research Bldg., W209B, 3970 Reservoir Road NW, Washington, DC, 20007, USA.
  slot:
    index: 3
    item: Garcia-Cairasco N
      type: Person
      first name: Norberto
      last name: Garcia-Cairasco
      member of: Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, SP, Brazil.Department of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
  slot:
    index: 4
    item: N'Gouemo P
      type: Person
      first name: Prosper
      last name: N'Gouemo
      member of: Department of Physiology and Biophysics, Howard University School of Medicine, Washington, DC, 20059, USA. prosper.ngouemo@howard.edu.
  slot:
    index: 5
    item: Forcelli PA
      type: Person
      first name: Patrick A
      last name: Forcelli
      member of: Department of Pharmacology and Physiology, Georgetown University, New Research Bldg., W209B, 3970 Reservoir Road NW, Washington, DC, 20007, USA. paf22@georgetown.edu.Department of Neuroscience, Georgetown University, Washington, DC, USA. paf22@georgetown.edu.
created: 2022-10-5T06:00
date last updated: 2025-03-09
issued: 2023-02
dp: 2023 Feb
created: 2022-10-4T23:22
e ISSN: 2299-5684
has issn l: 1734-1140
issue: 1
has NLM journal title abbreviation: Pharmacol Rep
publication name: Pharmacological reports : PR
language: eng
has national library of medicine journal id: 101234999
derived from: NLM
starting page: 166
ending page: 176
has place of publication: Switzerland
has primary subject term: D002185Q000494
has primary subject term: D007696Q000502
has primary subject term: D020195Q000188Q000235
has subject term: D051381
has subject term: D000818
has subject term: D012640Q000188
has subject term: D001933
has subject term: D009536Q000494
has subject term: D000161
has subject term: D004195
source: Pharmacol Rep. 2023-02;75(1):166-176.
volume: 75

Concomitant Diseases and Co-contribution on Progression of Liver Stiffness in Patients with Hepatitis B Virus Infection.
pmid: 36227429
abstract: The association between hepatitis B and concomitant diseases, such as fatty liver, T2DM, MetS, and Hp infection, remains unclear.The present study was to illustrate the association and explore the co-contribution on abnormal transaminase and progression of liver stiffness.A total of 95,998 participants underwent HBsAg screening in West China Hospital from 2014 to 2017. Multivariable logistic regression was used to determine the adjusted odds ratios.The prevalence of HBsAg-positive rate was 8.30% of our included study population. HBsAg positive was associated with negative risk of fatty liver (odds ratio [OR] 0.71, 95% confidence interval [CI] 0.65-0.78, p < 0.001) and MetS (OR 0.74, 95% CI 0.67-0.84, p < 0.001), and with positive risk of Hp infection (OR 1.09, 95% CI 1.02-1.17, p = 0.012) and T2DM (OR 1.18, 95% CI 1.01-1.40, p = 0.043). Besides, HBsAg-positive patients with T2DM had higher risk of elevated ALT (OR 2.09, 95% CI 1.69-2.83, p < 0.001 vs OR 1.59, 95% CI 1.51-1.68, p < 0.001), AST (OR 2.69, 95% CI 1.98-3.65, p < 0.001 vs OR 1.89, 95% CI 1.76-2.02, p < 0.001) than HBV alone. In addition to HBV, T2DM also can increase the risk of liver fibrosis (OR 3.23, 95% CI 1.35-7.71, p = 0.008) and cirrhosis (OR 4.31, 95% CI 1.41-13.20, p = 0.010).Hepatitis B patients have a lower risk of fatty liver and MetS, and a higher risk of T2DM and Hp infection. Besides, T2DM might be possibly associated with abnormal liver transaminase and fibrosis progression in HBsAg-positive patients.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07695-2
doi: 10.1007/s10620-022-07695-2
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Liu CH
      type: Person
      first name: Chang-Hai
      last name: Liu
      member of: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
  slot:
    index: 2
    item: Jiang W
      type: Person
      first name: Wei
      last name: Jiang
      member of: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
  slot:
    index: 3
    item: Wu DB
      type: Person
      first name: Dong-Bo
      last name: Wu
      member of: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
  slot:
    index: 4
    item: Zeng QM
      type: Person
      first name: Qing-Min
      last name: Zeng
      member of: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
  slot:
    index: 5
    item: Wang YJ
      type: Person
      first name: You-Juan
      last name: Wang
      member of: Health Management Center, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 6
    item: Tang H
      type: Person
      first name: Hong
      last name: Tang
      member of: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China. htang6198@hotmail.com.Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China. htang6198@hotmail.com.
created: 2022-10-14T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-13T11:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1605
ending page: 1614
has place of publication: United States
has primary subject term: D006509Q000150Q000453
has primary subject term: D005234Q000150
has primary subject term: D003924Q000150
has subject term: D006801
has subject term: D006515
has subject term: D006514
has subject term: D008103Q000175Q000453Q000150
has subject term: D000410
source: Dig Dis Sci. 2023-04;68(4):1605-1614.
volume: 68

Endo-histologic Normalization Is Achievable with Tofacitinib and Is Associated with Improved Clinical Outcomes.
pmid: 36242686
abstract: Recent real-world effectiveness studies investigating tofacitinib have been encouraging. Questions remain regarding the long-term effectiveness and safety of tofacitinib, effect on endoscopic remission rates, histologic changes, and alterations in fecal calprotectin levels.This retrospective study includes consecutive patients with inflammatory bowel disease (IBD) who initiated tofacitinib therapy. We reviewed electronic medical records for demographic and clinical data, as well as all adverse events and hospitalizations. All patients receiving tofacitinib were included in the safety analysis and only patients with ulcerative colitis (UC) were included in the effectiveness analysis.119 patients with IBD (97 UC, 12 CD, and 10 pouchitis) seen at our center between 2014 and 2020 were included in this study. Median follow-up was 32 weeks (interquartile range (IQR) 3-252). Clinical response and remission were observed in 70% and 21%, 59% and 33%, and 49%, and 37% at weeks 8, 24, and 52, respectively. Endo-histologic healing was achieved by 11%, 25%, and 37.5% of patients at weeks 8, 24, and 52, respectively. Histologic normalization occurred as early as 24 weeks in this cohort and was achieved by 26% of patients in endoscopic remission. Overall, there were 27 (25%) adverse events with 6 (5%) resulting in treatment discontinuation. There were 11 (10%) infections, none required treatment discontinuation. Ten (10.3%) patients underwent colectomy during the follow-up period. There were no cardiovascular adverse events in the cohort during follow-up.This study demonstrates the effectiveness and long-term safety of tofacitinib in patients with UC. Importantly, we show that the endpoint of endo-histologic healing is achievable with tofacitinib and can occur as early as week 8 of therapy.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07716-0
doi: 10.1007/s10620-022-07716-0
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Cohen NA
      type: Person
      first name: Nathaniel A
      last name: Cohen
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  slot:
    index: 2
    item: Steinberg JM
      type: Person
      first name: Joshua M
      last name: Steinberg
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 3
    item: Silfen A
      type: Person
      first name: Alexa
      last name: Silfen
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 4
    item: Traboulsi C
      type: Person
      first name: Cindy
      last name: Traboulsi
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 5
    item: Rodriguez TG
      type: Person
      first name: Tina G
      last name: Rodriguez
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 6
    item: Singer JM
      type: Person
      first name: Jorie M
      last name: Singer
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 7
    item: Patel S
      type: Person
      first name: Shivani
      last name: Patel
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 8
    item: Cohen RD
      type: Person
      first name: Russell D
      last name: Cohen
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 9
    item: Dalal SR
      type: Person
      first name: Sushila R
      last name: Dalal
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 10
    item: Sakuraba A
      type: Person
      first name: Atsushi
      last name: Sakuraba
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 11
    item: Pekow J
      type: Person
      first name: Joel
      last name: Pekow
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 12
    item: Micic D
      type: Person
      first name: Dejan
      last name: Micic
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA.
  slot:
    index: 13
    item: Rubin DT
      type: Person
      first name: David T
      last name: Rubin
      member of: University of Chicago Medicine Inflammatory Bowel Disease Center, 5841 S. Maryland Avenue, MC 4076, Chicago, IL, 60637, USA. drubin@medicine.bsd.uchicago.edu.
created: 2022-10-16T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-15T11:16
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1464
ending page: 1472
has place of publication: United States
has primary subject term: D003093Q000175Q000188Q000473
has primary subject term: D015212Q000188
has subject term: D006801
has subject term: D012189
has subject term: D010880Q000009
source: Dig Dis Sci. 2023-04;68(4):1464-1472.
volume: 68

Clinical Outcomes of Inside Stents and Conventional Plastic Stents as Bridge-to-Surgery Options for Malignant Hilar Biliary Obstruction.
pmid: 36242688
abstract: The appropriate method of preoperative endoscopic biliary drainage (EBD) for cholangiocarcinoma with hilar biliary obstruction remains controversial. The inside-stent technique is a method of placing plastic stents entirely inside the bile duct. Several studies of patients with unresectable stage have reported longer stent patency compared with conventional endoscopic biliary stenting (EBS). Inside-stent techniques have been introduced as a bridge-to-surgery option and as an alternative to conventional EBS.We aimed to evaluate the clinical outcomes of inside stent use and conventional EBS.During this retrospective multicenter study, we reviewed consecutive patients with cholangiocarcinoma who underwent radical surgery after conventional EBS or inside-stent insertion. Adverse event (AE) rates after EBD and post-surgical AEs were compared. A multivariable analysis was performed to identify factors affecting cholangitis after EBD.Conventional EBS and inside-stent procedures were performed for 56 and 73 patients, respectively. Patient backgrounds were similar between groups, except for percutaneous transhepatic portal vein embolization. The waiting time before surgery was similar between groups (28.5 days vs. 30 days). There were no significant differences in the cholangitis rate (21.4% vs. 26.0%; P = 0.68) and all AEs (25.0% vs. 30.1%; P = 0.56) between groups. The post-surgical AE rate was similar between the groups. The multivariable analysis found that preprocedural cholangitis was a risk factor for cholangitis after EBD (odds ratio: 5.67; 95% confidence interval: 1.61-19.9).The outcomes of inside-stent techniques and conventional EBS for the management of preoperative EBD are comparable for patients with cholangiocarcinoma.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07718-y
doi: 10.1007/s10620-022-07718-y
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Ishiwatari H
      type: Person
      first name: Hirotoshi
      last name: Ishiwatari
      member of: Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun, Shizuoka, Japan. ishihiro481019@gmail.com.
  slot:
    index: 2
    item: Kawabata T
      type: Person
      first name: Takanori
      last name: Kawabata
      member of: Clinical Research Center, Shizuoka Cancer Center, Shizuoka, Japan.
  slot:
    index: 3
    item: Kawashima H
      type: Person
      first name: Hiroki
      last name: Kawashima
      member of: Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan.
  slot:
    index: 4
    item: Nakai Y
      type: Person
      first name: Yousuke
      last name: Nakai
      member of: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  slot:
    index: 5
    item: Miura S
      type: Person
      first name: Shin
      last name: Miura
      member of: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  slot:
    index: 6
    item: Kato H
      type: Person
      first name: Hironari
      last name: Kato
      member of: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
  slot:
    index: 7
    item: Shiomi H
      type: Person
      first name: Hideyuki
      last name: Shiomi
      member of: Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.Division of Gastroenterology and Hepato-Biliary-Pancreatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
  slot:
    index: 8
    item: Fujimori N
      type: Person
      first name: Nao
      last name: Fujimori
      member of: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 9
    item: Ogura T
      type: Person
      first name: Takeshi
      last name: Ogura
      member of: Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University (Osaka Medical College), Osaka, Japan.
  slot:
    index: 10
    item: Inatomi O
      type: Person
      first name: Osamu
      last name: Inatomi
      member of: Division of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Otsu, Japan.
  slot:
    index: 11
    item: Kubota K
      type: Person
      first name: Kensuke
      last name: Kubota
      member of: Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  slot:
    index: 12
    item: Fujisawa T
      type: Person
      first name: Toshio
      last name: Fujisawa
      member of: Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
  slot:
    index: 13
    item: Takenaka M
      type: Person
      first name: Mamoru
      last name: Takenaka
      member of: Department of Gastroenterology and Hepatology, Faculty of Medicine, Kindai University, Osaka, Japan.
  slot:
    index: 14
    item: Mori H
      type: Person
      first name: Hiroshi
      last name: Mori
      member of: Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan.
  slot:
    index: 15
    item: Noguchi K
      type: Person
      first name: Kensaku
      last name: Noguchi
      member of: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  slot:
    index: 16
    item: Fujii Y
      type: Person
      first name: Yuki
      last name: Fujii
      member of: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
  slot:
    index: 17
    item: Sugiura T
      type: Person
      first name: Teiichi
      last name: Sugiura
      member of: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  slot:
    index: 18
    item: Ideno N
      type: Person
      first name: Noboru
      last name: Ideno
      member of: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 19
    item: Nakafusa T
      type: Person
      first name: Tomoki
      last name: Nakafusa
      member of: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 20
    item: Masamune A
      type: Person
      first name: Atsushi
      last name: Masamune
      member of: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  slot:
    index: 21
    item: Isayama H
      type: Person
      first name: Hiroyuki
      last name: Isayama
      member of: Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
  slot:
    index: 22
    item: Sasahira N
      type: Person
      first name: Naoki
      last name: Sasahira
      member of: Division of Hepato-Biliary-Pancreatic Medicine, Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
created: 2022-10-16T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-15T11:16
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1139
ending page: 1147
has place of publication: United States
has primary subject term: D001650Q000150Q000601Q000473
has primary subject term: D018281Q000150Q000601
has primary subject term: D002779Q000000981Q000209Q000601
has primary subject term: D002761Q000150
has subject term: D006801
has subject term: D016896
has subject term: D012189
has subject term: D001653Q000473
has subject term: D015607Q000009
has subject term: D010969
has subject term: D004322Q000009Q000379
has subject term: D015337
source: Dig Dis Sci. 2023-04;68(4):1139-1147.
volume: 68

Mid-Term and Long-Term Outcomes of Peroral Endoscopic Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis.
pmid: 36260203
abstract: Peroral endoscopic myotomy (POEM) achieves a satisfactory short-term clinical response in patients with achalasia. However, data on mid- and long-term clinical outcomes are limited. We aimed to assess the mid- and long-term efficacy and safety of POEM in achalasia patients.Using the pre-designed search strategy, we identified relevant studies that evaluated the efficacy and safety of POEM with a minimum of 2-year follow-up in the Embase, Cochrane, and PubMed databases from inception to January 2021. Primary outcome was pooled mid- and long-term clinical success rate based on the Eckardt score. Secondary outcome was pooled long-term reflux-related adverse events.A total of 21 studies involving 2,698 patients were included. Overall, the pooled clinical success rates with 2-, 3-, 4-, and 5-year follow-ups were 91.3% (95% confidence interval [CI] 88.4-93.6%), 90.4% (95% CI 88.1-92.2%), 89.8% (95% CI 83.6-93.9%), and 82.2% (95% CI 76.6-86.7%), respectively. Besides, the pooled long-term clinical success rates for type I, II, and III achalasia were 86.1% (95% CI 80.9-90.1%; I2 = 0%), 87.9% (95% CI 84.2-90.8%; I2 = 48.354%), and 83.9% (95% CI 72.5-91.2%; I2 = 0%), respectively. Moreover, the pooled incidence of symptomatic reflux and reflux esophagitis was 23.9% (95% CI 18.7-29.9%) and 16.7% (95% CI 11.9-23.1%), respectively.POEM is associated with a long-term clinical success of 82.2% after 5 years of follow-up. Randomized control trials comparing POEM with laparoscopic Heller myotomy or pneumatic dilation with longer follow-up periods are needed to further demonstrate the long-term safety and efficacy of POEM.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07720-4
doi: 10.1007/s10620-022-07720-4
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Zhang H
      type: Person
      first name: Han
      last name: Zhang
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 2
    item: Zeng X
      type: Person
      first name: Xinyi
      last name: Zeng
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 3
    item: Huang S
      type: Person
      first name: Shu
      last name: Huang
      member of: Department of Gastroenterology, The People's Hospital of Lianshui, Huaian, China.
  slot:
    index: 4
    item: Shi L
      type: Person
      first name: Lei
      last name: Shi
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 5
    item: Xia H
      type: Person
      first name: Huifang
      last name: Xia
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 6
    item: Jiang J
      type: Person
      first name: Jiao
      last name: Jiang
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 7
    item: Ren W
      type: Person
      first name: Wensen
      last name: Ren
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 8
    item: Peng Y
      type: Person
      first name: Yan
      last name: Peng
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 9
    item: Lü M
      type: Person
      first name: Muhan
      last name: Lü
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
  slot:
    index: 10
    item: Tang X
      type: Person
      first name: Xiaowei
      last name: Tang
      member of: Department of Gastroenterology, The Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China. solitude5834@hotmail.com.
created: 2022-10-20T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-19T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1386
ending page: 1396
has place of publication: United States
has primary subject term: D004931Q000601Q000150
has primary subject term: D005764Q000209
has primary subject term: D000074434Q000009
has primary subject term: D057605Q000009
has subject term: D006801
has subject term: D016896
has subject term: D004106
has subject term: D049630Q000601
source: Dig Dis Sci. 2023-04;68(4):1386-1396.
volume: 68

Existing Bowel Preparation Quality Scales Are Reliable in the Setting of Centralized Endoscopy Reading.
pmid: 36266592
abstract: Development of bowel preparation products has been based upon colon cleansing rating by a local endoscopist. It is unclear how bowel preparation scales perform when centrally evaluated.To evaluate the reliability of bowel preparation quality scales when assessed by central readers.Four central readers evaluated 52 videos in triplicate, 2 weeks apart, during the entire endoscopic procedure (insertion/withdrawal of the colonoscope) and exclusively on colonoscope withdrawal using the Boston Bowel Preparation Scale (BBPS), Chicago Bowel Preparation scale, Harefield Cleansing Scale, Ottawa Bowel Preparation Quality Scale (OBPQS), Aronchick score, a visual analogue scale, and additional items proposed in a modified Research and Development/University of California Los Angeles appropriateness process. Reliability was assessed with intraclass correlation coefficients.Intraclass correlation coefficients (95% confidence interval) for inter-rater reliability of the quality scales ranged from 0.51 to 0.65 (consistent with moderate to substantial inter-rater reliability) during the entire procedure. Corresponding intraclass correlation coefficients for intra-rater reliability ranged from 0.69 to 0.77 (consistent with substantial intra-rater reliability). Reliability was highest in the right colon and lowest in the left colon. No differences were observed in reliability when assessed for the procedure overall (insertion/withdrawal) relative to assessment on withdrawal alone.All five bowel preparation quality scales had moderate to substantial inter-rater reliability. Panelists considered the Aronchick score too simplistic for clinical trials and recognized that assessment of residual fluid in the Ottawa Bowel Preparation Quality Scale was not amenable to central assessment.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07729-9
doi: 10.1007/s10620-022-07729-9
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Hanzel J
      type: Person
      first name: Jurij
      last name: Hanzel
      member of: Department of Gastroenterology and Hepatology, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.Faculty of Medicine, University of Ljubljana, University Medical Centre Ljubljana, Zaloška Cesta 7, 1000, Ljubljana, Slovenia.Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada.
  slot:
    index: 2
    item: Sey M
      type: Person
      first name: Michael
      last name: Sey
      member of: Division of Gastroenterology, Department of Medicine, Western University & London Health Sciences Centre, University Hospital, 1151 Richmond St, Room A10-219, London, ON, Canada.Lawson Health Research Institute, London Health Sciences Centre-Victoria Hospital, 800 Commissioners Rd E, London, ON, Canada.
  slot:
    index: 3
    item: Ma C
      type: Person
      first name: Christopher
      last name: Ma
      member of: Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada.Division of Gastroenterology & Hepatology, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University Calgary, 2500 University Dr NW, Calgary, AB, Canada.
  slot:
    index: 4
    item: Zou G
      type: Person
      first name: Guangyong
      last name: Zou
      member of: Department of Epidemiology and Biostatistics, Western University, 1151 Richmond St, London, ON, Canada.
  slot:
    index: 5
    item: East JE
      type: Person
      first name: James E
      last name: East
      member of: Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX1 2JD, UK.Division of Gastroenterology and Hepatology, Mayo Clinic Healthcare, 15 Portland Pl, London, UK.
  slot:
    index: 6
    item: Siegel CA
      type: Person
      first name: Corey A
      last name: Siegel
      member of: Section of Gastroenterology & Hepatology, Department of Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH, USA.
  slot:
    index: 7
    item: Mosli M
      type: Person
      first name: Mahmoud
      last name: Mosli
      member of: Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, 22254, Saudi Arabia.
  slot:
    index: 8
    item: Reinisch W
      type: Person
      first name: Walter
      last name: Reinisch
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
  slot:
    index: 9
    item: McDonald JWD
      type: Person
      first name: John W D
      last name: McDonald
      member of: Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada.
  slot:
    index: 10
    item: Silverberg MS
      type: Person
      first name: Mark S
      last name: Silverberg
      member of: Inflammatory Bowel Disease Centre, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada.
  slot:
    index: 11
    item: Van Viegen T
      type: Person
      first name: Tanja
      last name: Van Viegen
      member of: Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada.
  slot:
    index: 12
    item: Shackelton LM
      type: Person
      first name: Lisa M
      last name: Shackelton
      member of: Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada.
  slot:
    index: 13
    item: Clayton LB
      type: Person
      first name: Lucy B
      last name: Clayton
      member of: Norgine Ltd, Widewater Place Moorhall Road, Harefield, England, UK.
  slot:
    index: 14
    item: Enns R
      type: Person
      first name: Robert
      last name: Enns
      member of: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada.
  slot:
    index: 15
    item: Epstein I
      type: Person
      first name: Ian
      last name: Epstein
      member of: Division of Digestive Care & Endoscopy, Department of Medicine, Dalhousie University, 6299 South St, Halifax, NS, Canada.
  slot:
    index: 16
    item: Hilsden RJ
      type: Person
      first name: Robert J
      last name: Hilsden
      member of: Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 2500 University Dr NW, Calgary, AB, Canada.Forzani & MacPhail Colon Cancer Screening Centre, Alberta Health Services, 3280 Hospital Dr NW, Calgary, AB, Canada.
  slot:
    index: 17
    item: Hookey L
      type: Person
      first name: Lawrence
      last name: Hookey
      member of: Gastrointestinal Diseases Research Unit, Department of Medicine, Queen's University, 99 University Ave, Kingston, ON, Canada.
  slot:
    index: 18
    item: Moffatt DC
      type: Person
      first name: Dana C
      last name: Moffatt
      member of: Department of Medicine, Max Rady College of Medicine, University of Manitoba, 66 Chancellors Cir, Winnipeg, Canada.
  slot:
    index: 19
    item: Ng Kwet Shing R
      type: Person
      first name: Richard
      last name: Ng Kwet Shing
      member of: Norgine Ltd, Widewater Place Moorhall Road, Harefield, England, UK.
  slot:
    index: 20
    item: Telford JJ
      type: Person
      first name: Jennifer J
      last name: Telford
      member of: Division of Gastroenterology, Department of Medicine, St. Paul's Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada.
  slot:
    index: 21
    item: von Renteln D
      type: Person
      first name: Daniel
      last name: von Renteln
      member of: Division of Gastroenterology, Department of Medicine, Université de Montréal, 2900 Edouard Montpetit Blvd, Montreal, QC, Canada.
  slot:
    index: 22
    item: Feagan BG
      type: Person
      first name: Brian G
      last name: Feagan
      member of: Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada.Division of Gastroenterology, Department of Medicine, Western University & London Health Sciences Centre, University Hospital, 1151 Richmond St, Room A10-219, London, ON, Canada.Department of Epidemiology and Biostatistics, Western University, 1151 Richmond St, London, ON, Canada.
  slot:
    index: 23
    item: Barkun A
      type: Person
      first name: Alan
      last name: Barkun
      member of: Division of Gastroenterology, McGill University and McGill University Health Centre, 845 Sherbrooke St W, Montreal, QC, Canada.
  slot:
    index: 24
    item: Jairath V
      type: Person
      first name: Vipul
      last name: Jairath
      member of: Alimentiv Inc, 100 Dundas St Suite 200, London, ON, Canada. vjairath@uwo.ca.Division of Gastroenterology, Department of Medicine, Western University & London Health Sciences Centre, University Hospital, 1151 Richmond St, Room A10-219, London, ON, Canada. vjairath@uwo.ca.Department of Epidemiology and Biostatistics, Western University, 1151 Richmond St, London, ON, Canada. vjairath@uwo.ca.
created: 2022-10-21T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-20T23:57
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1195
ending page: 1207
has place of publication: United States
has primary subject term: D003113Q000379
has primary subject term: D002400
has subject term: D006801
has subject term: D015203
has subject term: D016099
has subject term: D003106
source: Dig Dis Sci. 2023-04;68(4):1195-1207.
volume: 68

Missing Causality and Heritability of Autoimmune Hepatitis.
pmid: 36261672
abstract: Autoimmune hepatitis has an unknown cause and genetic associations that are not disease-specific or always present. Clarification of its missing causality and heritability could improve prevention and management strategies.Describe the key epigenetic and genetic mechanisms that could account for missing causality and heritability in autoimmune hepatitis; indicate the prospects of these mechanisms as pivotal factors; and encourage investigations of their pathogenic role and therapeutic potential.English abstracts were identified in PubMed using multiple key search phases. Several hundred abstracts and 210 full-length articles were reviewed.Environmental induction of epigenetic changes is the prime candidate for explaining the missing causality of autoimmune hepatitis. Environmental factors (diet, toxic exposures) can alter chromatin structure and the production of micro-ribonucleic acids that affect gene expression. Epistatic interaction between unsuspected genes is the prime candidate for explaining the missing heritability. The non-additive, interactive effects of multiple genes could enhance their impact on the propensity and phenotype of autoimmune hepatitis. Transgenerational inheritance of acquired epigenetic marks constitutes another mechanism of transmitting parental adaptations that could affect susceptibility. Management strategies could range from lifestyle adjustments and nutritional supplements to precision editing of the epigenetic landscape.Autoimmune hepatitis has a missing causality that might be explained by epigenetic changes induced by environmental factors and a missing heritability that might reflect epistatic gene interactions or transgenerational transmission of acquired epigenetic marks. These unassessed or under-evaluated areas warrant investigation.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07728-w
doi: 10.1007/s10620-022-07728-w
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Czaja AJ
      type: Person
      first name: Albert J
      last name: Czaja
      member of: Mayo Clinic College of Medicine and Science, Rochester, MN, USA. czaja.albert@mayo.edu.Professor Emeritus of Medicine, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA. czaja.albert@mayo.edu.
created: 2022-10-20T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-19T23:39
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1585
ending page: 1604
has place of publication: United States
has primary subject term: D019693
has subject term: D006801
has subject term: D044127
has subject term: D010641
source: Dig Dis Sci. 2023-04;68(4):1585-1604.
volume: 68

Safety and Efficacy of Sedation During Emergency Endoscopy for Upper Gastrointestinal Bleeding: A Propensity Score Matching Analysis.
pmid: 36272038
abstract: This study aimed to compare patients with and without sedation during emergency endoscopy for upper gastrointestinal bleeding (UGIB) and to clarify the safety and efficacy of sedation in emergency endoscopy.We retrospectively collected 389 patients who underwent emergency endoscopy for UGIB at Ureshino Medical Center from 2016 to 2021. Patients were divided into two groups: sedation group during emergency endoscopy and nonsedation group. Clinical characteristics, patient status on admission, and UGIB etiology were evaluated. Treatment outcomes and adverse events were evaluated using propensity score matching (PSM), and risk factors for mortality from UGIB were investigated using Cox multivariate analysis.The sedation group was significantly younger, composed of a higher proportion of males, and had chronic liver disease. Blood pressure and hemoglobin level on admission were significantly higher in the sedation group. The main cause of bleeding was peptic ulcer, which was significantly higher in the nonsedation group. PSM created 133 matched pairs. The success rate of endoscopic hemostasis was similar in both groups, and procedure time was significantly shorter in the sedation group than in the nonsedation group (17.6 ± 10.0 versus 20.2 ± 10.2 min, P = 0.04). There were no significant differences in adverse events between groups. Cox multivariate analyses revealed that red blood cell transfusion [hazard ratio (HR) 4.45, P < 0.02] and rebleeding (HR 3.30, P = 0.03) were associated with increased risk of 30-day mortality from UGIB.Sedation reduced the procedure time during emergency endoscopy for UGIB. Sedation during emergency endoscopy for UGIB is acceptable for safe endoscopic procedures.
rights: © 2022. The Author(s).
has PII: 10.1007/s10620-022-07740-0
doi: 10.1007/s10620-022-07740-0
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Yamaguchi D
      type: Person
      first name: Daisuke
      last name: Yamaguchi
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan. daisukehawks@gmail.com.Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan. daisukehawks@gmail.com.
  slot:
    index: 2
    item: Nagatsuma G
      type: Person
      first name: Goshi
      last name: Nagatsuma
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 3
    item: Sakata Y
      type: Person
      first name: Yasuhisa
      last name: Sakata
      member of: Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.
  slot:
    index: 4
    item: Mizuta Y
      type: Person
      first name: Yumi
      last name: Mizuta
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 5
    item: Nomura T
      type: Person
      first name: Tadahiro
      last name: Nomura
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 6
    item: Jinnouchi A
      type: Person
      first name: Azuki
      last name: Jinnouchi
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 7
    item: Gondo K
      type: Person
      first name: Kasumi
      last name: Gondo
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 8
    item: Asahi R
      type: Person
      first name: Ryosuke
      last name: Asahi
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 9
    item: Ishida S
      type: Person
      first name: Satoshi
      last name: Ishida
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 10
    item: Kimura S
      type: Person
      first name: Shunichiro
      last name: Kimura
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 11
    item: Fujimoto S
      type: Person
      first name: Shun
      last name: Fujimoto
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 12
    item: Shimakura A
      type: Person
      first name: Akane
      last name: Shimakura
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 13
    item: Jubashi A
      type: Person
      first name: Amane
      last name: Jubashi
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 14
    item: Takeuchi Y
      type: Person
      first name: Yuki
      last name: Takeuchi
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 15
    item: Ikeda K
      type: Person
      first name: Kei
      last name: Ikeda
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 16
    item: Tanaka Y
      type: Person
      first name: Yuichiro
      last name: Tanaka
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 17
    item: Yoshioka W
      type: Person
      first name: Wataru
      last name: Yoshioka
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 18
    item: Hino N
      type: Person
      first name: Naoyuki
      last name: Hino
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 19
    item: Morisaki T
      type: Person
      first name: Tomohito
      last name: Morisaki
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 20
    item: Ario K
      type: Person
      first name: Keisuke
      last name: Ario
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 21
    item: Tsunada S
      type: Person
      first name: Seiji
      last name: Tsunada
      member of: Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
  slot:
    index: 22
    item: Esaki M
      type: Person
      first name: Motohiro
      last name: Esaki
      member of: Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 849-8501, Japan.
created: 2022-10-23T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-22T11:18
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1426
ending page: 1434
has place of publication: United States
has primary subject term: D006471Q000175Q000209Q000628
has primary subject term: D010437Q000150
has subject term: D008297
has subject term: D006801
has subject term: D012189
has subject term: D057216
has subject term: D016099Q000009
source: Dig Dis Sci. 2023-04;68(4):1426-1434.
volume: 68

Clinical Outcomes of Patients with Benign Peptic Ulcer Bleeding After an Emergency Endoscopy Based on Patient Location.
pmid: 36284035
abstract: In the efforts toward reducing bleeding-related mortality, it is crucial to determine the risk factors for rebleeding after endoscopic hemostasis in benign peptic ulcer (BPU).Between 2013 and 2017, the medical records of 864 BPU patients were selected from 5076 who had undergone emergency endoscopy for suspected upper gastrointestinal bleeding. Patients who visited the emergency room or were hospitalized for other illnesses were selected. The primary end point was rebleeding within 30 days after initial endoscopy. The risk factors of rebleeding and subgroup analyses according to patient location were evaluated.Among 864 BPU bleeding patients, rebleeding after completion of BPU bleeding occurred in 140 (16.2%). Initial indicators of hypotension (OR 1.878, p = 0.005) and Forrest classes Ia (OR 25.53, p < 0.001), Ib (OR 27.91, p = 0.005), IIa (OR 21.41, p < 0.001), and IIb (OR 23.74, p < 0.001) were independent risk factors of rebleeding compared to Forrest class III, and being inpatients (OR 1.75, p = 0.01). Compared to the outpatients, the inpatients showed significantly higher rebleeding rates (25.6% vs 13.8%, p < 0.001), predictive bleeding scores, red blood transfusion counts, proportion of Forrest classes Ia, Ib, and IIb (p < 0.001), and overall mortality rates (68.8% vs 34.0%, p < 0.001).Patient location was a novel predictive factor of BPU rebleeding. Particularly, being an inpatient correlated with increased rebleeding. Furthermore, Forrest classes Ia, Ib, IIa, and IIb were predictive of rebleeding not only the included BPUs, but also in the inpatient or outpatient groups.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07708-0
doi: 10.1007/s10620-022-07708-0
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Cha B
      type: Person
      first name: Boram
      last name: Cha
      member of: Department of Internal Medicine, Digestive Disease Center, Inha University School of Medicine, Incheon, Republic of Korea.
  slot:
    index: 2
    item: Noh JH
      type: Person
      first name: Jin Hee
      last name: Noh
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 3
    item: Ahn JY
      type: Person
      first name: Ji Yong
      last name: Ahn
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea. ji110@hanmail.net.
  slot:
    index: 4
    item: Lee JS
      type: Person
      first name: Jun Su
      last name: Lee
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 5
    item: Kim GH
      type: Person
      first name: Ga Hee
      last name: Kim
      member of: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
  slot:
    index: 6
    item: Na HK
      type: Person
      first name: Hee Kyong
      last name: Na
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 7
    item: Jung KW
      type: Person
      first name: Kee Wook
      last name: Jung
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 8
    item: Lee JH
      type: Person
      first name: Jeong Hoon
      last name: Lee
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 9
    item: Kim DH
      type: Person
      first name: Do Hoon
      last name: Kim
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 10
    item: Choi KD
      type: Person
      first name: Kee Don
      last name: Choi
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 11
    item: Song HJ
      type: Person
      first name: Ho June
      last name: Song
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 12
    item: Lee GH
      type: Person
      first name: Gin Hyug
      last name: Lee
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
  slot:
    index: 13
    item: Jung HY
      type: Person
      first name: Hwoon-Yong
      last name: Jung
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
created: 2022-10-26T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-25T23:16
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1539
ending page: 1550
has place of publication: United States
has primary subject term: D010437
has primary subject term: D016558
has subject term: D006801
has subject term: D010438Q000175Q000628
has subject term: D016099
has subject term: D006471Q000175Q000209Q000628
has subject term: D012008
source: Dig Dis Sci. 2023-04;68(4):1539-1550.
volume: 68

Epigenetic Effects in HPA Axis Genes Associated with Cortical Thickness, ERP Components and SUD Outcome.
pmid: 36285916
abstract: Association between familial loading for alcohol use disorders (AUD) and event-related potentials (ERPs) suggests a genetic basis for these oscillations though much less is known about epigenetic pathways influenced by environmental variation. Early life adversity (ELA) influences negative outcomes much later in life. The stress-activated neuropeptide corticotropin-releasing hormone (CRH) contributes to the deleterious effects of ELA on brain structure and function in animals. Accordingly, we hypothesized that ELA would be related to cortical thickness and electrophysiological characteristics through an epigenetic effect on CRH receptor type-1 (CRHR1) methylation. A total of 217 adolescent and young adult participants from either multiplex alcohol dependence or control families were scanned using magnetic resonance imaging (MRI) at 3T and cortical thickness was determined. Longitudinal follow-up across childhood, adolescence, and young adulthood provided developmental ERP data and measures of adversity. Blood samples for genetic and epigenetic analyses were obtained in childhood. Cortical thickness and visual ERP components were analyzed for their association and tested for familial risk group differences. Visual P300 amplitude at Pz and cortical thickness of the left lateral orbitofrontal region (LOFC), were significantly related to risk group status. LOFC cortical thickness showed a negative correlation with CRHR1 methylation status and with childhood total stress scores from the Life Stressors and Social Resources Inventory (LISRES). Stress scores were also significantly related to P300 amplitude recorded in childhood. The present results suggest that early life adversity reflected in greater total LISRES stress scores in childhood can impact the methylation of the CRHR1 gene with implications for brain development as seen in cortical thickness and electrophysiological signals emanating from particular brain regions.
has PII: bs12100347
doi: 10.3390/bs12100347
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Hill SY
      type: Person
      first name: Shirley Y
      last name: Hill
      member of: Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
  slot:
    index: 2
    item: Wellman JL
      type: Person
      first name: Jeannette L
      last name: Wellman
      member of: Department of Psychiatry and Magee Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
  slot:
    index: 3
    item: Zezza N
      type: Person
      first name: Nicholas
      last name: Zezza
      member of: Department of Psychiatry and Shadyside Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
  slot:
    index: 4
    item: Steinhauer SR
      type: Person
      first name: Stuart R
      last name: Steinhauer
      member of: Pittsburgh VA Medical Center, University Drive C, Pittsburgh, PA 15240, USA.
  slot:
    index: 5
    item: Sharma V
      type: Person
      first name: Vinod
      last name: Sharma
      member of: Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
  slot:
    index: 6
    item: Holmes B
      type: Person
      first name: Brian
      last name: Holmes
      member of: UPMC Children's Hospital of Pittsburgh, 4401 Penn Ave., Pittsburgh, PA 15224, USA.
created: 2022-10-27T06:00
date last updated: 2025-03-09
issued: 2022-09-20
dp: 2022 Sep 20
created: 2022-10-26T07:12
ISSN: 2076-328X
has issn l: 2076-328X
issue: 10
has NLM journal title abbreviation: Behav Sci (Basel)
publication name: Behavioral sciences (Basel, Switzerland)
language: eng
has national library of medicine journal id: 101576826
derived from: NLM
has place of publication: Switzerland
source: Behav Sci (Basel). 2022-09-20;12(10):.
volume: 12

Cleaning the Flue in Wood-Burning Stoves Is a Key Factor in Reducing Household Air Pollution.
pmid: 36287895
abstract: In experimental settings, replacing old wood stoves with new wood stoves results in reduced personal exposure to household air pollution. We tested this assumption by measuring PM2.5 and levoglucosan concentrations inside homes and correlated them with wood stove age. Methods: Thirty homes in the Albuquerque, NM area were monitored over a seven-day period using in-home particulate monitors placed in a common living area during the winter months. Real-time aerosol monitoring was performed, and filter samples were analyzed gravimetrically to calculate PM2.5 concentrations and chemically to determine concentrations of levoglucosan. A linear regression model with backward stepwise elimination was performed to determine the factors that would predict household air pollution measures. Results: In this sample, 73.3% of the households used wood as their primary source of heating, and 60% burned daily or almost daily. The mean burn time over the test week was 50 ± 38 h, and only one household burned wood 24/day (168 h). The average PM2.5 concentration (standard deviation) for the 30 homes during the seven-day period was 34.6 µg/m3 (41.3 µg/m3), and median (min, max) values were 15.5 µg/m3 (7.3 µg/m3, 193 µg/m3). Average PM2.5 concentrations in 30 homes ranged from 0−15 μg/m3 to >100 μg/m3. Maximum PM2.5 concentrations ranged from 100−200 μg/m3 to >3000 μg/m3. The levoglucosan levels showed a linear correlation with the total PM2.5 collected by the filters (R2 = 0.92). However, neither mean nor peak PM2.5 nor levoglucosan levels were correlated with the age (10.85 ± 8.54 years) of the wood stove (R2 ≤ 0.07, p > 0.23). The final adjusted linear regression model showed that average PM2.5 was associated with reports of cleaning the flue with a beta estimate of 35.56 (3.47−67.65) and R2 = 0.16 (p = 0.04). Discussion: Cleaning the flue and not the wood stove age was associated with household air pollution indices. Education on wood stove maintenance and safe burning practices may [cell cut: 2086 characters, first 2000 kept]
has PII: toxics10100615
doi: 10.3390/toxics10100615
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Rahman M
      type: Person
      first name: Mizanur
      last name: Rahman
      member of: Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  slot:
    index: 2
    item: Petersen H
      type: Person
      first name: Hans
      last name: Petersen
      member of: Chronic Obstructive Pulmonary Disease Program, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.
  slot:
    index: 3
    item: Irshad H
      type: Person
      first name: Hammad
      last name: Irshad
      member of: Applied Sciences, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.
  slot:
    index: 4
    item: Liu C
      type: Person
      first name: Congjian
      last name: Liu
      member of: Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  slot:
    index: 5
    item: McDonald J
      type: Person
      first name: Jacob
      last name: McDonald
      member of: Applied Sciences, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA.
  slot:
    index: 6
    item: Sood A
      type: Person
      first name: Akshay
      last name: Sood
      member of: Department of Internal Medicine, University of New Mexico School of Medicine and Miners Colfax Medical Center, Raton, NM 87740, USA.
  slot:
    index: 7
    item: Meek PM
      type: Person
      first name: Paula M
      last name: Meek
      member of: Department of Internal Medicine, University of New Mexico School of Medicine and Miners Colfax Medical Center, Raton, NM 87740, USA.College of Nursing, University of Utah, Salt Lake City, UT 84102, USA.
  slot:
    index: 8
    item: Tesfaigzi Y
      type: Person
      first name: Yohannes
      last name: Tesfaigzi
      member of: Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
created: 2022-10-27T06:00
date last updated: 2025-03-09
issued: 2022-10-17
dp: 2022 Oct 17
created: 2022-10-26T12:33
e ISSN: 2305-6304
has issn l: 2305-6304
issue: 10
has NLM journal title abbreviation: Toxics
publication name: Toxics
language: eng
has national library of medicine journal id: 101639637
derived from: NLM
has place of publication: Switzerland
source: Toxics. 2022-10-17;10(10):.
volume: 10

Feline Oncogenomics: What Do We Know about the Genetics of Cancer in Domestic Cats?
pmid: 36288160
abstract: Cancer is a significant cause of morbidity and mortality in domestic cats. In humans, an understanding of the oncogenome of different cancer types has proven critical and is deeply interwoven into all aspects of patient care, including diagnostics, prognostics and treatments through the application of targeted therapies. Investigations into understanding the genetics of feline cancers started with cytogenetics and was then expanded to studies at a gene-specific level, looking for mutations and expression level changes of genes that are commonly mutated in human cancers. Methylation studies have also been performed and together with a recently generated high-quality reference genome for cats, next-generation sequencing studies are starting to deliver results. This review summarises what is currently known of the genetics of both common and rare cancer types in cats, including lymphomas, mammary tumours, squamous cell carcinomas, soft tissue tumours, mast cell tumours, haemangiosarcomas, pulmonary carcinomas, pancreatic carcinomas and osteosarcomas. Shining a spotlight on our current understanding of the feline oncogenome will hopefully serve as a springboard for more much-needed research into the genetics of cancer in domestic cats.
has PII: vetsci9100547
doi: 10.3390/vetsci9100547
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ludwig L
      type: Person
      first name: Latasha
      last name: Ludwig
      member of: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  slot:
    index: 2
    item: Dobromylskyj M
      type: Person
      first name: Melanie
      last name: Dobromylskyj
      member of: Finn Pathologists, Histopathology Department, Diss, Norfolk IP21 5TT, UK.
  slot:
    index: 3
    item: Wood GA
      type: Person
      first name: Geoffrey A
      last name: Wood
      member of: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
  slot:
    index: 4
    item: van der Weyden L
      type: Person
      first name: Louise
      last name: van der Weyden
      member of: Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
created: 2022-10-27T06:00
date last updated: 2025-03-09
issued: 2022-10-04
dp: 2022 Oct 04
created: 2022-10-26T13:13
e ISSN: 2306-7381
has issn l: 2306-7381
issue: 10
has NLM journal title abbreviation: Vet Sci
publication name: Veterinary sciences
language: eng
has national library of medicine journal id: 101680127
derived from: NLM
has place of publication: Switzerland
source: Vet Sci. 2022-10-04;9(10):.
volume: 9

Gait Analysis of Bilateral Knee Osteoarthritis and Its Correlation with Western Ontario and McMaster University Osteoarthritis Index Assessment.
pmid: 36295577
abstract: Background and objectives: Objective, accurate, and intuitive evaluation of knee joint function in patients with knee osteoarthritis (KOA) is important. This study aimed to clarify the gait characteristics of patients with bilateral KOA and their correlation with Western Ontario and McMaster University Osteoarthritis Index (WOMAC). Materials and Methods: 20 patients with bilateral KOA and 20 conditionally matched healthy individuals were enrolled in the experimental and control groups, respectively. Footscan and CODA motion gait analysis systems were used to analyse the gait parameters. Gait spatiotemporal parameters and knee joint motion parameters were collected. Weight-bearing balance and walking stability were assessed using discrete trends of relevant gait indicators. Patients in the experimental group were evaluated using WOMAC. Pearson’s correlation analysis was performed on the gait data and WOMAC score data of the experimental group. Results: Velocity, cadence, step length, and stride length of the experimental group were significantly lower than those of the control group (p < 0.01). Step time and gait cycle were significantly greater in the experimental group than in the control group (p < 0.01). Total stance and double-stance times of the experimental group were significantly greater than those of the control group (p < 0.01), whereas the single-stance time was shorter than that of the control group (p < 0.01). The range of motion and maximum flexion angle in the experimental group were significantly lower than those in the control group (p < 0.01), and the minimum angle of knee extension was greater than that in the control group (p < 0.01). The discrete trend of weight-bearing balance and walking stability gait index in the experimental group was greater than that in the control group. The WOMAC score and gait analysis were significantly correlated (p < 0.05). Conclusions: The gait function of patients with KOA is significantly worse than that of norma[cell cut: 2129 characters, first 2000 kept]
has PII: medicina58101419
doi: 10.3390/medicina58101419
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Li H
      type: Person
      first name: Haoqian
      last name: Li
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
  slot:
    index: 2
    item: Hu S
      type: Person
      first name: Shuai
      last name: Hu
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
  slot:
    index: 3
    item: Zhao R
      type: Person
      first name: Ruipeng
      last name: Zhao
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
  slot:
    index: 4
    item: Zhang Y
      type: Person
      first name: Yixuan
      last name: Zhang
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
  slot:
    index: 5
    item: Huang L
      type: Person
      first name: Lingan
      last name: Huang
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.Department of Pain Medicine, Sanya Central Hospital of Hainan Medical College, 1154 Jiefang Road, Sanya 572000, China.
  slot:
    index: 6
    item: Shi J
      type: Person
      first name: Junjun
      last name: Shi
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
  slot:
    index: 7
    item: Li P
      type: Person
      first name: Pengcui
      last name: Li
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
  slot:
    index: 8
    item: Wei X
      type: Person
      first name: Xiaochun
      last name: Wei
      member of: Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan 030001, China.
created: 2022-10-28T06:00
date last updated: 2025-03-09
issued: 2022-10-09
dp: 2022 Oct 09
created: 2022-10-27T01:38
e ISSN: 1648-9144
has issn l: 1010-660X
issue: 10
has NLM journal title abbreviation: Medicina (Kaunas)
publication name: Medicina (Kaunas, Lithuania)
language: eng
has national library of medicine journal id: 9425208
derived from: NLM
has place of publication: Switzerland
has primary subject term: D020370Q000175
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000077107
has subject term: D014495
has subject term: D009864
has subject term: D005684
has subject term: D007719
source: Medicina (Kaunas). 2022-10-09;58(10):.
volume: 58

Heterologous SARS-CoV-2 IgA neutralising antibody responses in convalescent plasma.
pmid: 36299410
abstract: Following infection with SARS-CoV-2, virus-specific antibodies are generated, which can both neutralise virions and clear infection via Fc effector functions. The importance of IgG antibodies for protection and control of SARS-CoV-2 has been extensively reported. By comparison, other antibody isotypes including IgA have been poorly characterised.Here, we characterised plasma IgA from 41 early convalescent COVID-19 subjects for neutralisation and Fc effector functions.Convalescent plasma IgA from > 60% of the cohort had the capacity to inhibit the interaction between wild-type RBD and ACE2. Furthermore, a third of the cohort induced stronger IgA-mediated ACE2 inhibition than matched IgG when tested at equivalent concentrations. Plasma IgA and IgG from this cohort broadly recognised similar RBD epitopes and had similar capacities to inhibit ACE2 from binding to 22 of the 23 prevalent RBD mutations assessed. However, plasma IgA was largely incapable of mediating antibody-dependent phagocytosis in comparison with plasma IgG.Overall, convalescent plasma IgA contributed to the neutralising antibody response of wild-type SARS-CoV-2 RBD and various RBD mutations. However, this response displayed large heterogeneity and was less potent than IgG.
rights: © 2022 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
has PII: CTI21424
doi: 10.1002/cti2.1424
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Davis SK
      type: Person
      first name: Samantha K
      last name: Davis
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 2
    item: Selva KJ
      type: Person
      first name: Kevin John
      last name: Selva
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 3
    item: Lopez E
      type: Person
      first name: Ester
      last name: Lopez
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 4
    item: Haycroft ER
      type: Person
      first name: Ebene R
      last name: Haycroft
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 5
    item: Lee WS
      type: Person
      first name: Wen Shi
      last name: Lee
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia.
  slot:
    index: 6
    item: Wheatley AK
      type: Person
      first name: Adam K
      last name: Wheatley
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 7
    item: Juno JA
      type: Person
      first name: Jennifer A
      last name: Juno
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 8
    item: Adair A
      type: Person
      first name: Amy
      last name: Adair
      member of: The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia.
  slot:
    index: 9
    item: Pymm P
      type: Person
      first name: Phillip
      last name: Pymm
      member of: The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia.
  slot:
    index: 10
    item: Redmond SJ
      type: Person
      first name: Samuel J
      last name: Redmond
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 11
    item: Gherardin NA
      type: Person
      first name: Nicholas A
      last name: Gherardin
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 12
    item: Godfrey DI
      type: Person
      first name: Dale I
      last name: Godfrey
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
  slot:
    index: 13
    item: Tham WH
      type: Person
      first name: Wai-Hong
      last name: Tham
      member of: The Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia.
  slot:
    index: 14
    item: Kent SJ
      type: Person
      first name: Stephen J
      last name: Kent
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.Melbourne Sexual Health Centre and Department of Infectious Diseases Alfred Hospital and Central Clinical School Monash University Melbourne VIC Australia.
  slot:
    index: 15
    item: Chung AW
      type: Person
      first name: Amy W
      last name: Chung
      member of: Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne VIC Australia.
created: 2022-10-28T06:00
date last updated: 2025-03-09
issued: 2022
dp: 2022
created: 2022-10-27T02:22
ISSN: 2050-0068
has issn l: 2050-0068
issue: 10
has NLM journal title abbreviation: Clin Transl Immunology
publication name: Clinical & translational immunology
language: eng
has national library of medicine journal id: 101638268
derived from: NLM
pg: e1424
has place of publication: Australia
source: Clin Transl Immunology. 2022;11(10):e1424.
volume: 11

Prediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA).
pmid: 36304436
abstract: Background: Short telomere length (TL) and telomere attrition (TA) have been associated with age-related diseases. Objective: We assessed whether a genetic risk score for short TL (GRS-TL) combining seven TL-associated genetic variants identified in a European-ancestry genome-wide association study (GWAS) was associated with TL and TA over 10 years. Methods: Relative TL (T/S ratio) was measured by the quantitative polymerase chain reaction method for a sample of white, African American, and Hispanic participants, who attended Exam 1 and/or 5 of the Multi-Ethnic Study of Atherosclerosis (MESA). Our final sample included 1,227 participants for the TL analysis and 1,138 for the TA analysis. Participants were 45-84 years at Exam 1. We used a linear mixed effects model and adjusted for age, sex, and population structure. Models were stratified by race/ethnicity. Results: In the TL analysis, higher GRS-TL significantly predicted shorter TL (estimates = -0.18 [S.E. = 0.08], p = 0.02 for white; -0.18 [0.07], p < 0.01 for African American; and -0.13 [0.05], p = 0.02 for Hispanic) in fully adjusted models. In the TA analysis, no association between GRS-TL and TA over 10 years was found. Conclusion: Although GRS-TL was developed in European-ancestry populations, it was significantly associated with TL (but not TA) in all three race/ethnic groups examined.
rights: Copyright © 2022 Castro-Diehl, Smith, Zhao, Wang, Mukherjee, Seeman and Needham.
has PII: 1021051
doi: 10.3389/fragi.2022.1021051
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Castro-Diehl C
      type: Person
      first name: Cecilia
      last name: Castro-Diehl
      member of: Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, United States.
  slot:
    index: 2
    item: Smith JA
      type: Person
      first name: Jennifer A
      last name: Smith
      member of: Department of Epidemiology and Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, MI, United States.Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States.
  slot:
    index: 3
    item: Zhao W
      type: Person
      first name: Wei
      last name: Zhao
      member of: Department of Epidemiology and Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, MI, United States.
  slot:
    index: 4
    item: Wang X
      type: Person
      first name: Xu
      last name: Wang
      member of: Department of Biostatistics, University of Washington, Seattle, WA, United States.
  slot:
    index: 5
    item: Mukherjee B
      type: Person
      first name: Bhramar
      last name: Mukherjee
      member of: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States.
  slot:
    index: 6
    item: Seeman T
      type: Person
      first name: Teresa
      last name: Seeman
      member of: Department of Medicine, Division of Geriatrics, UCLA, Los Angeles, CA, United States.
  slot:
    index: 7
    item: Needham BL
      type: Person
      first name: Belinda L
      last name: Needham
      member of: Department of Epidemiology and Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, MI, United States.
created: 2022-10-29T06:00
date last updated: 2025-03-09
issued: 2022
dp: 2022
created: 2022-10-28T02:50
e ISSN: 2673-6217
has issn l: 2673-6217
has NLM journal title abbreviation: Front Aging
publication name: Frontiers in aging
language: eng
has national library of medicine journal id: 9918231199706676
derived from: NLM
pg: 1021051
has place of publication: Switzerland
source: Front Aging. 2022;3():1021051.
volume: 3

Ibero-American Endometriosis Patient Phenome: Demographics, Obstetric-Gynecologic Traits, and Symptomatology.
pmid: 36303995
abstract: Background: An international collaborative study was conducted to determine the demographic and clinical profiles of Hispanic/Latinx endometriosis patients from Latin America and Spain using the Minimal Clinical Questionnaire developed by the World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonization Project (EPHect). Methods: This is a cross-sectional study to collect self-reported data on demographics, lifestyle, and endometriosis symptoms of Hispanic/Latinx endometriosis patients from April 2019 to February 2020. The EPHect Minimal Clinical Questionnaire (EPQ-M) was translated into Spanish. Comprehension and length of the translated survey were assessed by Spanish-speaking women. An electronic link was distributed via social media of endometriosis patient associations from 11 Latin American countries and Spain. Descriptive statistics (frequency, means and SD, percentages, and proportions) and correlations were conducted using SPSSv26. Results: The questionnaire was completed by 1,378 participants from 23 countries; 94.6% had self-reported diagnosis of endometriosis. Diagnostic delay was 6.6 years. Most participants had higher education, private health insurance, and were employed. The most common symptoms were back/leg pain (85.4%) and fatigue (80.7%). The mean number of children was 1.5; 34.4% had miscarriages; the mean length of infertility was 3.7 years; 47.2% reported pregnancy complications. The most common hormone treatment was oral contraceptives (47.0%). The most common comorbidities were migraines (24.1%), polycystic ovary syndrome (PCOS) (22.2%), and irritable bowel syndrome (21.1%). Most participants (97.0%) experienced pelvic pain during menses; for 78.7%, pain was severe; 86.4% reported dyspareunia. The mean age of dysmenorrhea onset was 16.2 years (SD ± 6.1). Hormone treatments were underutilized, while impact was substantial. Pain catastrophizing scores were significantly correlated with pain intensity (p < 0.[cell cut: 2760 characters, first 2000 kept]
rights: Copyright © 2021 Flores-Caldera, Ramos-Echevarría, Oliveras-Torres, Santos-Piñero, Rivera-Mudafort, Soto-Soto, Hernández-Colón, Rivera-Hiraldo, Mas, Rodríguez-Rabassa, Bracero, Rolla and Ibero-American Endometriosis Association.
doi: 10.3389/frph.2021.667345
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Flores-Caldera I
      type: Person
      first name: Idhaliz
      last name: Flores-Caldera
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.Department of Ob-Gyn, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 2
    item: Ramos-Echevarría PM
      type: Person
      first name: Paola M
      last name: Ramos-Echevarría
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 3
    item: Oliveras-Torres JA
      type: Person
      first name: José A
      last name: Oliveras-Torres
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 4
    item: Santos-Piñero N
      type: Person
      first name: Natasha
      last name: Santos-Piñero
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 5
    item: Rivera-Mudafort ED
      type: Person
      first name: Estefanía D
      last name: Rivera-Mudafort
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 6
    item: Soto-Soto DM
      type: Person
      first name: Denisse M
      last name: Soto-Soto
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.San Lucas Episcopal Medical Center, Ponce, Puerto Rico.
  slot:
    index: 7
    item: Hernández-Colón B
      type: Person
      first name: Brian
      last name: Hernández-Colón
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 8
    item: Rivera-Hiraldo LE
      type: Person
      first name: Luis E
      last name: Rivera-Hiraldo
      member of: San Lucas Episcopal Medical Center, Ponce, Puerto Rico.
  slot:
    index: 9
    item: Mas L
      type: Person
      first name: Loraine
      last name: Mas
      member of: Department of Basic Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 10
    item: Rodríguez-Rabassa M
      type: Person
      first name: Mary
      last name: Rodríguez-Rabassa
      member of: School of Behavioral and Brain Sciences, Ponce Health Sciences University, Ponce, Puerto Rico.
  slot:
    index: 11
    item: Bracero NJ
      type: Person
      first name: Nabal J
      last name: Bracero
      member of: Department of Ob-Gyn, University of Puerto Rico, San J uan, Puerto Rico.
  slot:
    index: 12
    item: Rolla E
      type: Person
      first name: Edgardo
      last name: Rolla
      member of: Sociedad Argentina de Endometriosis, Buenos Aires, Argentina.Sociedad Argentina de Cirugía Laparoscópica, Buenos Aires, Argentina.
creator: Ibero-American Endometriosis Association
created: 2021-6-4T00:00
date last updated: 2025-03-09
issued: 2021
dp: 2021
created: 2022-10-28T02:41
e ISSN: 2673-3153
has issn l: 2673-3153
has NLM journal title abbreviation: Front Reprod Health
publication name: Frontiers in reproductive health
language: eng
has national library of medicine journal id: 9918230899006676
derived from: NLM
pg: 667345
has place of publication: Switzerland
source: Front Reprod Health. 2021;3():667345.
volume: 3

The Frequency of Germline BRCA and Non-BRCA HR-Gene-Variants in a Cohort of Pancreatic Cancer Patients.
pmid: 36315333
abstract: Germline DNA alterations affecting homologous recombination pathway genes have been associated with pancreatic cancer (PC) risk. BRCA2 is the most studied gene and affects the management of PC patients and their families. Even though recent reports have suggested a similar role of germline ATM pathogenic variants (PV) in familial PC, there is still a disagreement between experts on how it could affect patient management given the lack of proper PC risk estimates. We retrospectively analyzed the germline data of 257 PC patients among whom nearly 50% were sporadic cases. We showed similar frequencies of BRCA2 (4.9%) and ATM (4.4%) PV or likely pathogenic variants, which were not related to familial history. Based on our findings and that of the literature, we suggest including ATM gene among the panel of genes analyzed in PC patients pending the publication of prospective studies.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07733-z
doi: 10.1007/s10620-022-07733-z
creator: OrderedList
  length: 26
  slot:
    index: 1
    item: Baz M
      type: Person
      first name: M
      last name: Baz
      member of: Département d'Oncogénétique, Hôpital Saint Louis, APHP, Paris, France. maria.baz.baz@hotmail.com.
  slot:
    index: 2
    item: Gondran-Teiller V
      type: Person
      first name: V
      last name: Gondran-Teiller
      member of: Service de Génétique des Tumeurs, Gustave Roussy, Villejuif, France.
  slot:
    index: 3
    item: Bressac B
      type: Person
      first name: B
      last name: Bressac
      member of: Service de Génétique des Tumeurs, Gustave Roussy, Villejuif, France.
  slot:
    index: 4
    item: Cabaret O
      type: Person
      first name: O
      last name: Cabaret
      member of: Service Oncogénétique, Gustave Roussy, Villejuif, France.
  slot:
    index: 5
    item: Fievet A
      type: Person
      first name: A
      last name: Fievet
      member of: Service Oncogénétique, Gustave Roussy, Villejuif, France.
  slot:
    index: 6
    item: Dimaria M
      type: Person
      first name: M
      last name: Dimaria
      member of: Service Oncogénétique, Gustave Roussy, Villejuif, France.
  slot:
    index: 7
    item: Goldbarg V
      type: Person
      first name: V
      last name: Goldbarg
      member of: Service Oncogénétique, Gustave Roussy, Villejuif, France.
  slot:
    index: 8
    item: Colas C
      type: Person
      first name: C
      last name: Colas
      member of: Département de Génétique (Department of Genetics), Institut Curie, Paris, France.Paris Sciences & Lettres Research University, Paris, France.
  slot:
    index: 9
    item: Bonnet-Dupeyron MN
      type: Person
      first name: M N
      last name: Bonnet-Dupeyron
      member of: Department of Genetics, Valence Hospital's Center, Valence, France.
  slot:
    index: 10
    item: Tinat J
      type: Person
      first name: J
      last name: Tinat
      member of: Service de Génétique Médicale, Unité d'Oncogénétique, Centre Hospitalier, Universitaire de Bordeaux, Bordeaux, France.
  slot:
    index: 11
    item: Lebrun M
      type: Person
      first name: M
      last name: Lebrun
      member of: CHU Saint Etienne, Genetic Service, Hôpital de Nord, Saint Etienne, France.
  slot:
    index: 12
    item: Mari V
      type: Person
      first name: V
      last name: Mari
      member of: Centre Antoine Lacassagne, CLCC, Unité d'Oncogénétique, Nice, France.
  slot:
    index: 13
    item: Limacher JM
      type: Person
      first name: J M
      last name: Limacher
      member of: Genetics Department, Hôpitaux Civils de Colmar, Colmar, France.
  slot:
    index: 14
    item: Corsini C
      type: Person
      first name: C
      last name: Corsini
      member of: Department of Cancer Genetics, CHU Montpellier, Univ Montpellier, Montpellier, France.
  slot:
    index: 15
    item: Ginglinger E
      type: Person
      first name: E
      last name: Ginglinger
      member of: CH de Mulhouse, Service de Génétique, Mulhouse, France.
  slot:
    index: 16
    item: Saurin JC
      type: Person
      first name: J C
      last name: Saurin
      member of: Department of Endoscopy and Gastroenterology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
  slot:
    index: 17
    item: Brahimi A
      type: Person
      first name: A
      last name: Brahimi
      member of: Department of Clinical Genetics, CHU Lille, 59000, Lille, France.
  slot:
    index: 18
    item: Rouzier C
      type: Person
      first name: C
      last name: Rouzier
      member of: Université Côte d'Azur, CHU de Nice, INSERM, CNRS, IRCAN, Nice, France.
  slot:
    index: 19
    item: Giraud S
      type: Person
      first name: S
      last name: Giraud
      member of: Service de Génétique Clinique, Centre Hospitalier Lyon-Sud, Lyon, France.
  slot:
    index: 20
    item: Schuster H
      type: Person
      first name: H
      last name: Schuster
      member of: Service d'Oncogénétique, CLCC Paul Strauss, Strasbourg, France.
  slot:
    index: 21
    item: Hollebecque A
      type: Person
      first name: A
      last name: Hollebecque
      member of: Département de Médecine Oncologique, Gustave Roussy, Villejuif, France.Université Paris-Saclay, Villejuif, France.
  slot:
    index: 22
    item: Boige V
      type: Person
      first name: V
      last name: Boige
      member of: Département de Médecine Oncologique, Gustave Roussy, Villejuif, France.Université Paris-Saclay, Villejuif, France.
  slot:
    index: 23
    item: Cauchin E
      type: Person
      first name: E
      last name: Cauchin
      member of: Institut de Cancérologie de l'Ouest René Gauducheau, Saint-Herblain, Nantes, France.
  slot:
    index: 24
    item: Malka D
      type: Person
      first name: D
      last name: Malka
      member of: Département de Médecine Oncologique, Gustave Roussy, Villejuif, France.Université Paris-Saclay, Villejuif, France.
  slot:
    index: 25
    item: Caron O
      type: Person
      first name: O
      last name: Caron
      member of: Service Oncogénétique, Gustave Roussy, Villejuif, France.
  slot:
    index: 26
    item: Rouleau E
      type: Person
      first name: E
      last name: Rouleau
      member of: Service de Génétique des Tumeurs, Gustave Roussy, Villejuif, France.
created: 2022-11-1T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-10-31T12:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1525
ending page: 1528
has place of publication: United States
has primary subject term: D020022
has primary subject term: D010190Q000235Q000473
has subject term: D006801
has subject term: D012189
has subject term: D011446
has subject term: D018095
source: Dig Dis Sci. 2023-04;68(4):1525-1528.
volume: 68

Pre-existing, Concurrent/Early-Onset, and Late-Onset Diabetes in Chronic Pancreatitis: Do Outcomes Differ?
pmid: 36318379
abstract: Diabetes secondary to endocrine insufficiency in chronic pancreatitis (CP) may develop at any time during the disease course. We sought to evaluate the differences in clinical characteristics and outcomes in CP patients with pre-existing, early-onset, and late-onset diabetes.We reviewed CP patients seen at our Pancreas Center during 2016-2021. We divided them into four groups: those without diabetes, with pre-existing diabetes, with early-onset diabetes, and with late-onset diabetes. We then compared clinical characteristics and outcomes.We identified 450 patients with CP: 271 without diabetes, 99 with pre-existing diabetes, 51 with early-onset diabetes, and 29 with late-onset diabetes. Early-onset diabetics were younger (54.1 vs 57.3 vs 62.5 vs 61.9 years), had more alcohol-related CP (45.1% vs 31.7% vs 32.3% vs 31%), had higher HbA1C levels (8.02% vs 5.11% vs 7.71% vs 7.66%), were more likely to be on insulin (78.4% vs 0% vs 48.4% vs 65.5%), and used more opioids (64.7% vs 43.9% vs 55.1% vs 44.8%) and gabapentinoids (66.7% vs 43.5% vs 48% vs 60.7%) compared to other groups (p < 0.05). Patients who developed diabetes after CP diagnosis had more exocrine insufficiency (72.4% vs 70.6% vs 65.7% vs 53.1%), anatomical complications, and interventions for pain control (p < 0.05). There was no difference in pancreatic cancer in the four groups.CP patients who are younger and use alcohol are at higher risk of having early-onset diabetes and have poorer glucose control compared other CP patients. Patients who develop diabetes after CP diagnosis have worse outcomes and use more resources.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07742-y
doi: 10.1007/s10620-022-07742-y
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zuberi SA
      type: Person
      first name: Shaharyar A
      last name: Zuberi
      member of: Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
  slot:
    index: 2
    item: Shah I
      type: Person
      first name: Ishani
      last name: Shah
      member of: Division of Gastroenterology, Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
  slot:
    index: 3
    item: Bocchino RL
      type: Person
      first name: Rachel L
      last name: Bocchino
      member of: Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
  slot:
    index: 4
    item: Ahmed A
      type: Person
      first name: Awais
      last name: Ahmed
      member of: Division of Gastroenterology, Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
  slot:
    index: 5
    item: Freedman SD
      type: Person
      first name: Steven D
      last name: Freedman
      member of: Division of Gastroenterology, Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
  slot:
    index: 6
    item: Kothari DJ
      type: Person
      first name: Darshan J
      last name: Kothari
      member of: Division of Gastroenterology, Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA.
  slot:
    index: 7
    item: Sheth SG
      type: Person
      first name: Sunil G
      last name: Sheth
      member of: Division of Gastroenterology, Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. ssheth@bidmc.harvard.edu.
created: 2022-11-2T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-11-1T12:20
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1519
ending page: 1524
has place of publication: United States
has primary subject term: D050500Q000150Q000175Q000453
has primary subject term: D003924Q000150Q000175Q000453
has primary subject term: D010190Q000150
has subject term: D006801
has subject term: D010179
has subject term: D007328Q000627
source: Dig Dis Sci. 2023-04;68(4):1519-1524.
volume: 68

M1/M2 Muscularis Macrophages Are Associated with Reduction of Interstitial Cells of Cajal and Glial Cells in Achalasia.
pmid: 36346489
abstract: Several studies showed muscularis macrophages (MMφ) are associated with GI motility disorders. The purpose of this study was to preliminary explore the association between MMφ and achalasia.Tissue samples of the lower esophageal sphincter (LES) high-pressure zone were obtained from 27 achalasia patients and 10 controls. Immunohistochemistry for MMφ, interstitial cells of Cajal (ICC), neuronal nitric oxide synthase (nNOS), and glial cells were conducted. Histological characteristics were compared between groups, and correlation analysis was performed.Fewer ICC was found in achalasia compared with controls (P = 0.018), and the level of M1 macrophages was higher than that in controls no matter in terms of the number or the proportion of M1(P = 0.026 for M1 and 0.037 for M1/MMφ). Statistical differences were found between two groups in terms of proportion of M2 and ratio of M1 to M2 (P = 0.048 for M2/ MMφ and < 0.001 for M1/M2). For the correlation analysis, significant correlations were detected between levels of nNOS, ICC, and glial cells in patients with achalasia (P = 0.026 for nNOS and ICC, 0.001 for nNOS and glial cells, 0.019 for ICC and glial cells). There were significant correlations between M2/MMφ and levels of ICC (P = 0.019), glial cells (P = 0.004), and nNOS (P = 0.135).Patients with achalasia had a higher level of M1/M2 ratio in LES and significant correlations were found between M2/MMφ and numbers of ICC and glial cells, which suggested that MMφ were probably associated with occurrence and development of achalasia.
rights: © 2022. The Author(s).
has PII: 10.1007/s10620-022-07734-y
doi: 10.1007/s10620-022-07734-y
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Qian H
      type: Person
      first name: Haisheng
      last name: Qian
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 2
    item: Wang Y
      type: Person
      first name: Yanjuan
      last name: Wang
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 3
    item: Chen X
      type: Person
      first name: Xiaosu
      last name: Chen
      member of: Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.
  slot:
    index: 4
    item: Lin L
      type: Person
      first name: Lin
      last name: Lin
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 5
    item: Zhang W
      type: Person
      first name: Weifeng
      last name: Zhang
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 6
    item: Wang Y
      type: Person
      first name: Yun
      last name: Wang
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 7
    item: Tang N
      type: Person
      first name: Nana
      last name: Tang
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 8
    item: Si X
      type: Person
      first name: Xinmin
      last name: Si
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 9
    item: Jiao C
      type: Person
      first name: Chunhua
      last name: Jiao
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 10
    item: Zhang G
      type: Person
      first name: Guoxin
      last name: Zhang
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China.
  slot:
    index: 11
    item: Ye B
      type: Person
      first name: Bixing
      last name: Ye
      member of: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China. nydybx@163.com.Department of Gastroenterology, The First School of Clinical Medicine of Nanjing Medical University, Nanjing, Jiangsu Province, China. nydybx@163.com.
created: 2022-11-9T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-11-8T11:15
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1260
ending page: 1268
has place of publication: United States
has primary subject term: D004931Q000473
has primary subject term: D056885Q000473
has subject term: D006801
has subject term: D008264Q000473
has subject term: D007150
has subject term: D009457Q000473
source: Dig Dis Sci. 2023-04;68(4):1260-1268.
volume: 68

Hydrogen Availability Is Dependent on the Actions of Both Hydrogen-Producing and Hydrogen-Consuming Microbes.
pmid: 36323965
abstract: Hydrogen gas (H2) is produced by H2-producing microbes in the gut during polysaccharide fermentation. Gut microbiome also includes H2-consuming microbes utilizing H2 for metabolism: methanogens producing methane, CH4, and sulfate-reducing bacteria producing hydrogen sulfide, H2S. H2S is not measured in the evaluation of gaseous byproducts of microbial fermentation. We hypothesize that the availability of measured H2 depends on both hydrogen producers and hydrogen consumers by measuring H2 in vitro and in vivo. In the in vitro study, groups were Bacteroides thetaiotaomicron (B. theta, H2 producers), Desulfovibrio vulgaris (D. vulgaris, H2 consumers), and D. vulgaris + B. theta combined. Gas samples were collected at 2 h and 24 h after incubation and assayed for H2, CH4, and H2S. In the in vivo study Sprague-Dawley rats were gavaged with suspended bacteria in four groups: B. theta, D. vulgaris, combined, and control. Gas was analyzed for H2 at 60 min. In the in vitro experiment, H2 concentration was higher in the combined group (188 ± 93.3 ppm) compared with D. vulgaris (27.17 ± 9.6 ppm) and B. theta groups (34.2 ± 29.8 ppm; P < 0.05); H2S concentration was statistically higher in the combined group (10.32 ± 1.5 ppm) compared with B. theta (0.19 ± 0.03 ppm) and D. vulgaris group (3.46 ± 0.28 ppm; P < 0.05). In the in vivo study, H2 concentrations were significantly higher in the B. theta group (44.3 ± 6.0 ppm) compared with control (31.8 ± 4.3) and the combined group (34.2 ± 8.7, P < 0.05). This study shows that sulfate-reducing bacteria could convert available H2 to H2S, leading to measured hydrogen levels that are dependent on the actions of both H2 producers and H2 consumers.
rights: © 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
has PII: 10.1007/s10620-022-07743-x
doi: 10.1007/s10620-022-07743-x
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Birg A
      type: Person
      first name: Aleksandr
      last name: Birg
      member of: Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM, 87106, USA.
  slot:
    index: 2
    item: Ritz N
      type: Person
      first name: Nathaniel
      last name: Ritz
      member of: Biomedical Research Institute of New Mexico, Albuquerque, NM, 87108, USA.
  slot:
    index: 3
    item: Barton LL
      type: Person
      first name: Larry L
      last name: Barton
      member of: Department of Biology, University of New Mexico, Albuquerque, NM, 87131, USA.
  slot:
    index: 4
    item: Lin HC
      type: Person
      first name: Henry C
      last name: Lin
      member of: Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM, 87106, USA. helin@salud.unm.edu.Medicine Service, New Mexico VA Health Care System, 1501 San Pedro St., Albuquerque, NM, 87108, USA. helin@salud.unm.edu.
created: 2022-11-4T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-11-3T00:39
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1253
ending page: 1259
has place of publication: United States
has primary subject term: D006859
has primary subject term: D003901
has subject term: D000818
has subject term: D051381
has subject term: D017207
has subject term: D001419
has subject term: D008697
has subject term: D013431
source: Dig Dis Sci. 2023-04;68(4):1253-1259.
volume: 68

Underwater Versus Conventional Endoscopic Mucosal Resection for Superficial Non-ampullary Duodenal Epithelial Tumors: A Systematic Review and Meta-Analysis.
pmid: 36346490
abstract: Duodenal underwater endoscopic mucosal resection (UEMR) has been suggested as a feasible treatment option for superficial non-ampullary duodenal epithelial tumors (SNADETs). However, its efficacy and safety have not been fully established yet. Thus, the objective of this systematic review and meta-analysis was to determine the efficacy and safety of UEMR as compared with conventional endoscopic mucosal resection (CEMR) in the treatment of SNADETs.We conducted a comprehensive literature search in PubMed, EMBASE, the Cochrane Library. Studies comparing CEMR and UEMR for the resection of SNADET were included. Outcomes included en-bloc and complete resection rates, adverse events, and procedure time.A total of six studies with 2454 lesions were included in the quantitative synthesis. En-bloc and complete resection rates were not significantly different between UEMR and CEMR (OR for en-bloc resection: 0.997 [95% CI 0.439-2.266]; OR for complete resection: 0.960 [95% CI 0.628-1.468]). There was no significant risk difference for perforation (risk difference: - 0.002; 95% CI - 0.009 to 0.005) or delayed bleeding (risk difference: - 0.001; 95% CI - 0.014 to 0.011). Procedure time was significantly shorter in the UEMR (standardized mean difference: - 1.294; 95% CI - 2.461 to - 0.127). The risk of recurrence was not significantly different between UEMR and CEMR (risk difference: 0.001; 95% CI - 0.041 to 0.044).Although our results did not show any superiority of UEMR over CEMR in the treatment of SNADETs, UEMR showed equivalent efficacy and safety as compared with CEMR and was associated with a shorter procedure time.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07715-1
doi: 10.1007/s10620-022-07715-1
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lee JG
      type: Person
      first name: Jae Gon
      last name: Lee
      member of: Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7 Keunjaebong-gil, Hwaseong, 18450, Korea.
  slot:
    index: 2
    item: Lee SP
      type: Person
      first name: Sang Pyo
      last name: Lee
      member of: Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7 Keunjaebong-gil, Hwaseong, 18450, Korea. ultra_pyo@hanmail.net.
  slot:
    index: 3
    item: Jang HJ
      type: Person
      first name: Hyun Joo
      last name: Jang
      member of: Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7 Keunjaebong-gil, Hwaseong, 18450, Korea.
  slot:
    index: 4
    item: Kae SH
      type: Person
      first name: Sea Hyub
      last name: Kae
      member of: Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7 Keunjaebong-gil, Hwaseong, 18450, Korea.
created: 2022-11-9T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-11-8T11:15
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1482
ending page: 1491
has place of publication: United States
has primary subject term: D000069916Q000009Q000379
has primary subject term: D004379Q000601Q000473
has primary subject term: D009375Q000209Q000473
has subject term: D006801
has subject term: D004386Q000601Q000473
has subject term: D016896
has subject term: D007413Q000601Q000473
source: Dig Dis Sci. 2023-04;68(4):1482-1491.
volume: 68

Cap-Assisted Endoscopic Esophageal Foreign Body Removal Is Safe and Efficacious Compared to Conventional Methods.
pmid: 36350475
abstract: Esophageal foreign body impaction (FBI) is a commonly encountered gastrointestinal emergency requiring immediate intervention. Foreign bodies can be composed of food, commonly referred to as a food bolus (FB), or other matter (non-food). We aim to conduct systematic review and meta-analysis to compare cap-assisted and conventional endoscopic techniques for removal of esophageal FBI.A comprehensive search technique was utilized to identify studies that used capped endoscopic devices to remove FB or other esophageal foreign bodies. The primary outcomes were the technical success rate, rate of en bloc retrieval, and procedure time. Secondary outcomes were overall adverse events, bleeding, mucosal tears, and perforation.Seven studies with a total of 1407 patients were included. The mean patient age was 55.3 (SD ± 7.2) years and 44.8% of patients were male. There were two RCTs and five observational studies among the included studies. The technical success rate was significantly higher in the cap-assisted group compared to the conventional group (OR 3.47, CI 1.68-7.168, I2 = 0%, p = < 0.001), as well as the en bloc retrieval rate (OR 26.90, CI 17.82-40.60, I2 = 0%, p = 0.001). There was a trend towards lower procedural time for the cap-assisted group compared to the conventional group, although the difference did not reach statistical significance (MD - 10.997, CI - 22.78-0.786, I2 = 99.9%, p = 0.06). The overall adverse events were significantly lower in the cap-assisted group compared to the conventional group (OR 0.118, CI 0.018-0.792, I2 = 81.79%, p = 0.02).The cap-assisted technique has improved efficacy and safety. To confirm these results, larger randomized trials are warranted.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07741-z
doi: 10.1007/s10620-022-07741-z
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Ahmed Z
      type: Person
      first name: Zohaib
      last name: Ahmed
      member of: Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA. Zohaib.Ahmed@utoledo.edu.
  slot:
    index: 2
    item: Arif SF
      type: Person
      first name: Syeda Faiza
      last name: Arif
      member of: Dow University of Health Sciences, Karachi, Pakistan.
  slot:
    index: 3
    item: Ong SL
      type: Person
      first name: Stephanie Lin
      last name: Ong
      member of: University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  slot:
    index: 4
    item: Badal J
      type: Person
      first name: Joyce
      last name: Badal
      member of: University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  slot:
    index: 5
    item: Lee-Smith W
      type: Person
      first name: Wade
      last name: Lee-Smith
      member of: University of Toledo Libraries, University of Toledo, Toledo, OH, USA.
  slot:
    index: 6
    item: Renno A
      type: Person
      first name: Anas
      last name: Renno
      member of: Division of Gastroenterology and Hepatology, University of Toledo Medical Center, Toledo, OH, USA.
  slot:
    index: 7
    item: Alastal Y
      type: Person
      first name: Yaseen
      last name: Alastal
      member of: Division of Gastroenterology and Hepatology, University of Toledo Medical Center, Toledo, OH, USA.
  slot:
    index: 8
    item: Nawras A
      type: Person
      first name: Ali
      last name: Nawras
      member of: Division of Gastroenterology and Hepatology, University of Toledo Medical Center, Toledo, OH, USA.
  slot:
    index: 9
    item: Aziz M
      type: Person
      first name: Muhammad
      last name: Aziz
      member of: Division of Gastroenterology and Hepatology, University of Toledo Medical Center, Toledo, OH, USA.
created: 2022-11-10T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-11-9T11:19
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1411
ending page: 1425
has place of publication: United States
has primary subject term: D004947Q000601
has primary subject term: D005547Q000000981Q000601
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D004724
has subject term: D005502
has subject term: D041981
has subject term: D012189
source: Dig Dis Sci. 2023-04;68(4):1411-1425.
volume: 68

Speckled Pigment of Upper GI Tract Mucosa on Endoscopy: A Case of Pseudomelanosis of the Stomach and Proximal Small Bowel.
pmid: 36534197
has PII: 10.1007/s10620-022-07757-5
doi: 10.1007/s10620-022-07757-5
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Abdul-Baki K
      type: Person
      first name: Kian
      last name: Abdul-Baki
      member of: Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA. ksabdulb@utmb.edu.
  slot:
    index: 2
    item: Tayyem OHS
      type: Person
      first name: Obada Hisham Saeed
      last name: Tayyem
      member of: Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, TX, USA.
  slot:
    index: 3
    item: Young P
      type: Person
      first name: Paul
      last name: Young
      member of: Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
  slot:
    index: 4
    item: Qiu S
      type: Person
      first name: Suimin
      last name: Qiu
      member of: Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
  slot:
    index: 5
    item: Aguirre J
      type: Person
      first name: Jose
      last name: Aguirre
      member of: Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, TX, USA.
created: 2022-12-20T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-12-19T11:16
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1075
ending page: 1076
has place of publication: United States
has primary subject term: D013270
has primary subject term: D041742
has subject term: D006801
has subject term: D016099
has subject term: D009092
has subject term: D004386
has subject term: D007413
source: Dig Dis Sci. 2023-04;68(4):1075-1076.
volume: 68

Sarcopenia Defined by Psoas Muscle Thickness Predicts Mortality After Transjugular Intrahepatic Portosystemic Shunt.
pmid: 36583804
abstract: To assess and compare the value of psoas muscle thickness at the level of the third lumbar (L3) vertebra (TPML) or umbilicus (TPMU) and skeletal muscle index (SMI) for diagnosing sarcopenia and predicting mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS).Two hundred forty-nine patients undergoing TIPS were included in this retrospective study. The cut-offs of L3-SMI for sarcopenia were 42.0 cm2/m2 in men and 38.0 cm2/m2 in women. The cut-offs for TPML/height and TPMU/height to predict mortality was established using a receiver-operating characteristic analysis. The Kaplan-Meier and Cox regression were used for survival analyses.Compared with TPMU/height, TPML/height was more consistent with L3-SM for the diagnosis of sarcopenia (Kappa coefficient: 0.63 vs. 0.36 in men; 0.61 vs. 0.45 in women). The Cox analysis showed that both TPML/height and TPMU/height were independent risk factors for mortality. The optimal cut-off values of TPML/height and TPMU/height for mortality in men and women were 11.2 mm/m, 9.4 mm/m, 18.4 mm/m, 15.1 mm/m, respectively. There were 119 (47.8%), 87 (34.9%), and 82 (32.9%) patients diagnosed with sarcopenia in the TPMU/height, TPML/height, and L3-SMI models, respectively. Kaplan-Meier analysis showed that the overall survival was significantly lower in the sarcopenia group in all three models.TPMU/height and TPML/height have a similar survival prognostic value as L3-SMI. TPML/height has better consistency with L3-SMI in diagnosing sarcopenia and is a more stable alternative to L3-SMI for diagnosing sarcopenia in patients undergoing TIPS.
rights: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07806-z
doi: 10.1007/s10620-022-07806-z
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Li T
      type: Person
      first name: Tongqiang
      last name: Li
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 2
    item: Liu J
      type: Person
      first name: Jiacheng
      last name: Liu
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 3
    item: Zhao J
      type: Person
      first name: Jianbo
      last name: Zhao
      member of: Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, China.
  slot:
    index: 4
    item: Bai Y
      type: Person
      first name: Yaowei
      last name: Bai
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 5
    item: Huang S
      type: Person
      first name: Songjiang
      last name: Huang
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 6
    item: Yang C
      type: Person
      first name: Chongtu
      last name: Yang
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 7
    item: Wang Y
      type: Person
      first name: Yingliang
      last name: Wang
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 8
    item: Zhou C
      type: Person
      first name: Chen
      last name: Zhou
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 9
    item: Wang C
      type: Person
      first name: Chaoyang
      last name: Wang
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 10
    item: Ju S
      type: Person
      first name: Shuguang
      last name: Ju
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 11
    item: Chen Y
      type: Person
      first name: Yang
      last name: Chen
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 12
    item: Yao W
      type: Person
      first name: Wei
      last name: Yao
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China.Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
  slot:
    index: 13
    item: Xiong B
      type: Person
      first name: Bin
      last name: Xiong
      member of: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China. herr_xiong@126.com.Department of Interventional Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. herr_xiong@126.com.
created: 2022-12-31T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2022-12-30T11:15
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1641
ending page: 1652
has place of publication: United States
has primary subject term: D055948Q000000981
has primary subject term: D019168Q000009
has subject term: D008297
has subject term: D006801
has subject term: D005260
has subject term: D016658Q000000981
has subject term: D008103Q000150
has subject term: D012189
has subject term: D018482
has subject term: D011379
source: Dig Dis Sci. 2023-04;68(4):1641-1652.
volume: 68

Using Virtual Reality for Deep Inferior Epigastric Perforator Flap Preoperative Planning.
pmid: 36660058
abstract: This study was designed to compare VR stereoscopical three-dimensional (3D) imaging with two-dimensional computed tomography angiography (CTA) images for evaluating the abdominal vascular anatomy before autologous breast reconstruction.This prospective case series feasibility study was conducted in two tertiary medical centers. Participants were women slated to undergo free transverse rectus abdominis muscle, unilateral or bilateral deep inferior epigastric perforator flap immediate breast reconstruction. Based on a routine CTA, a 3D VR model was generated. Before each procedure, the surgeons examined the CTA and then the VR model. Any new information provided by the VR imaging was submitted to a radiologist for confirmation before surgery. Following each procedure, the surgeons completed a questionnaire comparing the two methods.Thirty women between 34 and 68 years of age were included in the study; except for one, all breast reconstructions were successful. The surgeons ranked VR higher than CTA in terms of better anatomical understanding and operative anatomical findings. In 72.4% of cases, VR models were rated having maximum similarity to reality, with no significant difference between the type of perforator anatomical course or complexity. In more than 70% of the cases, VR was considered to have contributed to determining the surgical approach. In four cases, VR imaging modified the surgical strategy, without any complications.VR imaging was well-accepted by the surgeons who commented on its importance and ease compared with the standard CTA presentation. Further studies are needed to determine whether VR should become an integral part of preoperative deep inferior epigastric perforator surgery planning.
rights: Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
doi: 10.1097/GOX.0000000000004773
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Freidin D
      type: Person
      first name: Dor
      last name: Freidin
      member of: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Israel.
  slot:
    index: 2
    item: Singolda R
      type: Person
      first name: Roei
      last name: Singolda
      member of: Department of Plastic and Reconstructive Surgery, Tel Aviv Sourasky Medical Center, Israel.
  slot:
    index: 3
    item: Tejman-Yarden S
      type: Person
      first name: Shai
      last name: Tejman-Yarden
      member of: The Engineering Medical Research Lab, Sheba Medical Center, Israel.
  slot:
    index: 4
    item: Parmat I
      type: Person
      first name: Israel
      last name: Parmat
      member of: Department of Industrial Engineering and Management, Ben-Gurion University, Israel.
  slot:
    index: 5
    item: Liran A
      type: Person
      first name: Alon
      last name: Liran
      member of: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Israel.
  slot:
    index: 6
    item: Ofir H
      type: Person
      first name: Hagit
      last name: Ofir
      member of: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Israel.
  slot:
    index: 7
    item: Saukhat O
      type: Person
      first name: Olga
      last name: Saukhat
      member of: Department of Radiology, Sheba Medical Center, Israel.
  slot:
    index: 8
    item: Haik J
      type: Person
      first name: Josef
      last name: Haik
      member of: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Israel.Talpiot Medical Leadership Program, Sheba Medical Center, Israel.
  slot:
    index: 9
    item: Barnea Y
      type: Person
      first name: Yoav
      last name: Barnea
      member of: The Engineering Medical Research Lab, Sheba Medical Center, Israel.
  slot:
    index: 10
    item: Tessone A
      type: Person
      first name: Ariel
      last name: Tessone
      member of: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Israel.Talpiot Medical Leadership Program, Sheba Medical Center, Israel.
created: 2023-1-21T06:00
date last updated: 2025-03-09
issued: 2023-01
dp: 2023 Jan
created: 2023-1-20T02:05
ISSN: 2169-7574
has issn l: 2169-7574
issue: 1
has NLM journal title abbreviation: Plast Reconstr Surg Glob Open
publication name: Plastic and reconstructive surgery. Global open
language: eng
has national library of medicine journal id: 101622231
derived from: NLM
pg: e4773
has place of publication: United States
source: Plast Reconstr Surg Glob Open. 2023-01;11(1):e4773.
volume: 11

Self-Reported Gluten Intolerance Is Prevalent, but Not All Gluten-Containing Foods Are Equal.
pmid: 36662341
abstract: Celiac disease prevalence approaches 1%; more suffer from non-celiac gluten sensitivity.Our goal was to estimate the prevalence of gluten intolerance.We invited US adults (18-80 years) via Amazon's mechanical Turk to complete an online survey. Gluten intolerance was defined as self-reported intolerance to wheat, barley, rye, flour, or pasta. Those with celiac disease were not excluded.We collected 2133 responses. Rate of gluten intolerance was 5.1% (95% CI 4.2-6.1%). Each food had different rates: wheat 4.8%, flour 1.2%, pasta 0.9%, barley 0.8%, and rye 0.8%. Among 108 adults reporting any gluten intolerance, 62.0% selected only wheat, 10.2% selected all gluten-containing grains excluding pasta and flour, and 5.6% selected all gluten-containing products. Overall intolerance to any food was 24.8% (95% CI 23.0-26.6%). Wheat was second only to lactose.Self-reported intolerance to wheat, but not all gluten-containing foods, is common. Findings may suggest poor knowledge of gluten-containing foods or that self-perceived non-celiac gluten sensitivity is prevalent.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07800-5
doi: 10.1007/s10620-022-07800-5
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Jansson-Knodell CL
      type: Person
      first name: Claire L
      last name: Jansson-Knodell
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Suite 225, Indianapolis, IN, 46202, USA.Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
  slot:
    index: 2
    item: White M
      type: Person
      first name: Mattie
      last name: White
      member of: Internal Medicine, Department of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
  slot:
    index: 3
    item: Lockett C
      type: Person
      first name: Carolyn
      last name: Lockett
      member of: Roudebush VA Medical Center, 1481 W 10Th St, Indianapolis, IN, 46202, USA.
  slot:
    index: 4
    item: Xu H
      type: Person
      first name: Huiping
      last name: Xu
      member of: Department of Biostatistics, Indiana University School of Medicine, 410 W 10th Street, Indianapolis, IN, 46202, USA.
  slot:
    index: 5
    item: Rubio-Tapia A
      type: Person
      first name: Alberto
      last name: Rubio-Tapia
      member of: Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
  slot:
    index: 6
    item: Shin A
      type: Person
      first name: Andrea
      last name: Shin
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Suite 225, Indianapolis, IN, 46202, USA. ashin@iu.edu.
created: 2023-1-21T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2023-1-20T11:18
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1364
ending page: 1368
has place of publication: United States
has primary subject term: D005983Q000009
has primary subject term: D002446Q000175Q000453
has subject term: D000328
has subject term: D006801
has subject term: D057566
has subject term: D005502
has subject term: D011795
has subject term: D055050
source: Dig Dis Sci. 2023-04;68(4):1364-1368.
volume: 68

An updated norepinephrine equivalent score in intensive care as a marker of shock severity.
pmid: 36670410
abstract: Vasopressors and fluids are the cornerstones for the treatment of shock. The current international guidelines on shock recommend norepinephrine as the first-line vasopressor and vasopressin as the second-line vasopressor. In clinical practice, due to drug availability, local practice variations, special settings, and ongoing research, several alternative vasoconstrictors and adjuncts are used in the absence of precise equivalent doses. Norepinephrine equivalence (NEE) is frequently used in clinical trials to overcome this heterogeneity and describe vasopressor support in a standardized manner. NEE quantifies the total amount of vasopressors, considering the potency of each such agent, which typically includes catecholamines, derivatives, and vasopressin. Intensive care studies use NEE as an eligibility criterion and also an outcome measure. On the other hand, NEE has several pitfalls which clinicians should know, important the lack of conversion of novel vasopressors such as angiotensin II and also adjuncts such as methylene blue, including a lack of high-quality data to support the equation and validate its predictive performance in all types of critical care practice. This review describes the history of NEE and suggests an updated formula incorporating novel vasopressors and adjuncts.
rights: © 2023. The Author(s).
has PII: 10.1186/s13054-023-04322-y
doi: 10.1186/s13054-023-04322-y
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kotani Y
      type: Person
      first name: Yuki
      last name: Kotani
      member of: Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58, 20132, Milan, Italy.Department of Intensive Care Medicine, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan.
  slot:
    index: 2
    item: Di Gioia A
      type: Person
      first name: Annamaria
      last name: Di Gioia
      member of: Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
  slot:
    index: 3
    item: Landoni G
      type: Person
      first name: Giovanni
      last name: Landoni
      member of: Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. landoni.giovanni@hsr.it.School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58, 20132, Milan, Italy. landoni.giovanni@hsr.it.
  slot:
    index: 4
    item: Belletti A
      type: Person
      first name: Alessandro
      last name: Belletti
      member of: Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
  slot:
    index: 5
    item: Khanna AK
      type: Person
      first name: Ashish K
      last name: Khanna
      member of: Section on Critical Care Medicine, Department of Anesthesiology, Wake Forest Center for Biomedical Informatics, Perioperative Outcomes and Informatics Collaborative, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.Outcomes Research Consortium, Cleveland, OH, 44195, USA.
created: 2023-1-21T06:00
date last updated: 2025-03-08
issued: 2023-01-20
dp: 2023 01 20
created: 2023-1-20T23:36
e ISSN: 1466-609X
has issn l: 1364-8535
issue: 1
has NLM journal title abbreviation: Crit Care
publication name: Critical care (London, England)
language: eng
has national library of medicine journal id: 9801902
derived from: NLM
pg: 29
has place of publication: England
has primary subject term: D012772Q000188
has primary subject term: D012769Q000188
has subject term: D006801
has subject term: D009638Q000494Q000627
has subject term: D014662Q000494Q000627
has subject term: D014667Q000627
has subject term: D003422
source: Crit Care. 2023-01-20;27(1):29.
volume: 27

http://rdf.ncbi.nlm.nih.gov/pubmed/36700496
pmid: 36700496
abstract: Anticoagulation of patients supported by extracorporeal membrane oxygenation is challenging because of a high risk of both bleeding and thrombotic complications, and often empirical. Practice in anticoagulation management is therefore highly variable. The scope of this guidance document is to provide clinicians with practical advice on the choice of an anticoagulant agent, dosing, and the optimal anticoagulant monitoring strategy during extracorporeal membrane oxygenation support in adult patients.
rights: Copyright © 2022 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.
has PII: S1538-7836(22)07628-0
doi: 10.1016/j.jtha.2022.11.014
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Helms J
      type: Person
      first name: Julie
      last name: Helms
      member of: Strasbourg University (UNISTRA), Strasbourg University Hospital, Medical Intensive Care Unit - NHC, INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France. Electronic address: Julie.helms@chru-strasbourg.fr.
  slot:
    index: 2
    item: Frere C
      type: Person
      first name: Corinne
      last name: Frere
      member of: Sorbonne Université, UMRS 1166, AP-HP. Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, France.
  slot:
    index: 3
    item: Thiele T
      type: Person
      first name: Thomas
      last name: Thiele
      member of: Institut für Transfusionsmedizin, Universitätsmedizin Rostock, Schillingallee 36, Rostock, Germany.
  slot:
    index: 4
    item: Tanaka KA
      type: Person
      first name: Kenichi A
      last name: Tanaka
      member of: Department of Anesthesiology, Universit of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  slot:
    index: 5
    item: Neal MD
      type: Person
      first name: Matthew D
      last name: Neal
      member of: Department of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 6
    item: Steiner ME
      type: Person
      first name: Marie E
      last name: Steiner
      member of: Division of Hematology/Oncology and Division of Critical Care, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
  slot:
    index: 7
    item: Connors JM
      type: Person
      first name: Jean M
      last name: Connors
      member of: Hematology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 8
    item: Levy JH
      type: Person
      first name: Jerrold H
      last name: Levy
      member of: Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.
created: 2023-1-27T06:00
date last updated: 2025-03-08
issued: 2023-02
dp: 2023 02
created: 2023-1-26T06:51
e ISSN: 1538-7836
has issn l: 1538-7836
issue: 2
has NLM journal title abbreviation: J Thromb Haemost
publication name: Journal of thrombosis and haemostasis : JTH
language: eng
has national library of medicine journal id: 101170508
derived from: NLM
starting page: 373
ending page: 396
has place of publication: England
has primary subject term: D015199Q000009
has primary subject term: D013927Q000517Q000209
has subject term: D006801
has subject term: D000328
has subject term: D001777
has subject term: D000925Q000009
has subject term: D003422
has subject term: D006493
has subject term: D012189
source: J Thromb Haemost. 2023-02;21(2):373-396.
title: Anticoagulation in adult patients supported with extracorporeal membrane oxygenation: guidance from the Scientific and Standardization Committees on Perioperative and Critical Care Haemostasis and Thrombosis of the International Society on Thrombosis and Haemostasis.
volume: 21

A National Survey of the Infrastructure and Scope of Practice for Gastroenterology Hospitalists.
pmid: 36797510
abstract: Hospital-based specialty-trained physicians have become more prevalent with emerging data suggesting benefit in consult and procedure volume, reduced complication rates, and increased practice productivity. Interest in gastroenterology (GI) hospitalist programs has increased in recent years. However, little is known regarding the types of GI hospitalist models that currently exist.To characterize the infrastructure of GI hospitalist models across the USA.A 50-question survey was distributed to the GI Hospitalist Special Interest Group of the American Society for Gastrointestinal Endoscopy. Information on demographics, hospital infrastructure, and compensation were collected.31 of 33 (94%) GI hospitalists completed the questionnaire. Respondents were mostly male (65%), white (48%) or Asian (42%). Most GI hospitalists spent at least half of their clinical time dedicated to the inpatient consultation service (73%), during which they had no other clinical duties. Most services had endoscopy suites with dedicated inpatient endoscopy rooms (66%), over 4 h allotted for procedures (83%), and were available on weekends (62%). Over half of GI hospitalists reported having outpatient duties, the most common being performance of direct access endoscopy (69%). Outside of clinical responsibilities, GI hospitalists were most frequently involved in clinical education or fellowship program leadership (48%). Most GI hospitalists were salaried with an incentive-based bonus based on work relative value units.GI hospitalist programs are varied throughout the USA but key commonalities exist between most programs.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-023-07831-6
doi: 10.1007/s10620-023-07831-6
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Wan DW
      type: Person
      first name: David W
      last name: Wan
      member of: Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
  slot:
    index: 2
    item: Latorre M
      type: Person
      first name: Melissa
      last name: Latorre
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health, New York, NY, USA.
  slot:
    index: 3
    item: Sun E
      type: Person
      first name: Edward
      last name: Sun
      member of: Division of Gastroenterology and Hepatology, Department of Medicine, Stony Brook University Hospital, Stony Brook, NY, USA.
  slot:
    index: 4
    item: Hughes ML
      type: Person
      first name: Michelle L
      last name: Hughes
      member of: Section of Digestive Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
  slot:
    index: 5
    item: Buckholz A
      type: Person
      first name: Adam
      last name: Buckholz
      member of: Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.
  slot:
    index: 6
    item: Li DK
      type: Person
      first name: Darrick K
      last name: Li
      member of: Section of Digestive Diseases, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. darrick.li@yale.edu.
created: 2023-2-17T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2023-2-16T23:27
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1148
ending page: 1155
has place of publication: United States
has primary subject term: D020445
has primary subject term: D005762
has subject term: D006801
has subject term: D008297
has subject term: D014481
has subject term: D005260
has subject term: http://id.nlm.nih.gov/mesh/D000079103
has subject term: D011795
has subject term: D006761
source: Dig Dis Sci. 2023-04;68(4):1148-1155.
volume: 68

Hair Loss in Patients with Gastroparesis: A Sign of Nutritional Deficiency in Gastroparesis?
pmid: 36853546
abstract: Some patients with gastroparesis (Gp) report hair loss. The aim of this study was to investigate the prevalence of patient-reported hair loss in Gp patients, analyze hair loss association to severity of Gp and nutritional deficiencies, and study effects of multivitamin treatment on hair loss.Patients with Gp were questioned about hair characteristics, Gp symptoms, and diet. Patients with hair loss had blood drawn for vitamin levels. Patients with hair loss were treated with daily multivitamin and assessed 8 weeks later.Hair loss was reported in 65 of 143 patients with Gp (45.5%), occurring similarly in idiopathic and diabetic Gp. Hair loss was most commonly noticed while washing and/or combing hair. Patients with hair loss had more severe nausea, abdominal pain, stomach fullness, loss of appetite, abdominal discomfort, bloating, retching, stomach distension, vomiting, early satiety, postprandial fullness, and constipation. Hair loss patients lost more weight over prior 6 months. Patients with hair loss had similar gastric retention on gastric emptying scintigraphy. Overall, 29 of 61 (47.5%) patients with hair loss had at least one abnormal bloodwork result. After 8 weeks of treatment with a daily multivitamin, 17 of 41 (41%) patients had improvement in hair loss.Hair loss occurred in 46% of patients with Gp, being associated with more severe symptoms, loss of weight, and several vitamin deficiencies, although not a specific one. Treatment with multivitamins improved hair loss in 40% of patients. Presence of hair loss in patients with Gp should prompt nutritional evaluation and supplementation.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07803-2
doi: 10.1007/s10620-022-07803-2
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Silver PJ
      type: Person
      first name: Paul J
      last name: Silver
      member of: Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
  slot:
    index: 2
    item: Coles MJ
      type: Person
      first name: Michael J
      last name: Coles
      member of: Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
  slot:
    index: 3
    item: Heath CR
      type: Person
      first name: Candrice R
      last name: Heath
      member of: Department of Dermatology, Temple University School of Medicine, Philadelphia, PA, USA.
  slot:
    index: 4
    item: Parkman HP
      type: Person
      first name: Henry P
      last name: Parkman
      member of: Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA. henry.parkman@temple.edu.Gastroenterology Section, Temple University School of Medicine, Parkinson Pavilion, 8th floor, Philadelphia, PA, 19140, USA. henry.parkman@temple.edu.
created: 2023-3-1T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2023-2-28T11:39
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1397
ending page: 1402
has place of publication: United States
has primary subject term: D018589Q000175Q000453Q000209
has primary subject term: D044342Q000150
has subject term: D006801
has subject term: D005746
has subject term: D014839Q000453
has subject term: D009325
has subject term: D014815Q000494
source: Dig Dis Sci. 2023-04;68(4):1397-1402.
volume: 68

Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer.
pmid: 36877334
abstract: SALL4 has been demonstrated in many cancers and participated in tumorigenesis and tumor progression, however, its expression and function still remain ambiguous in GC, especially its upstream mechanistic modulators.We explored whether the dual mediation of EZH2 and KDM6A could be involved in upstream regulation of SALL4, which promotes GC cell progression via the Wnt/β-catenin pathway.Analysis of discrepant gene expression in GC and normal gastric tissues from The Cancer Genome Atlas (TCGA) dataset. GC cell lines were transfected by siEZH2 and siKDM6A, the transduction molecules of KDM6A/EZH2-SALL4-β-catenin signaling were quantified in the GC cells.Here, we showed that only SALL4 levels of SALL family members were upregulated in nonpaired and paired GC tissues than those in corresponding normal tissues and were associated with its histological types, pathological stages, TNM stages including T stage (local invasion), N stage (lymph node metastasis), M stage (distant metastasis), and overall survival from the TCGA dataset. SALL4 level was elevated in GC cells compared to normal gastric epithelial cell line (GES-1) and was correlated to cancer cell progression and invasion through the Wnt/β-catenin pathway in GC, which levels would be separately upregulated or downregulated by KDM6A or EZH2.We first proposed and demonstrated that SALL4 promoted GC cell progression via the Wnt/β-catenin pathway, which was mediated by the dual regulation of EZH2 and KDM6A on SALL4. This mechanistic pathway in gastric cancer represents a novel targetable pathway.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-022-07790-4
doi: 10.1007/s10620-022-07790-4
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ren L
      type: Person
      first name: Lei
      last name: Ren
      member of: Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.Department of Surgery, Klinikum Rechts Der Isar, Technical University of Munich, School of Medicine, Munich, Germany.
  slot:
    index: 2
    item: Deng H
      type: Person
      first name: Hong
      last name: Deng
      member of: Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
  slot:
    index: 3
    item: Jiang Y
      type: Person
      first name: Yu
      last name: Jiang
      member of: Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Taiping Str. 25, Luzhou, 646000, China.
  slot:
    index: 4
    item: Liu C
      type: Person
      first name: Chunfeng
      last name: Liu
      member of: Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Taiping Str. 25, Luzhou, 646000, China. Liu.Chunfeng@med.uni-muenchen.de.Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Taiping Str. 25, Luzhou, 646000, China. Liu.Chunfeng@med.uni-muenchen.de.Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University, Thalkirchner Str. 36, 80337, Munich, Germany. Liu.Chunfeng@med.uni-muenchen.de.
created: 2023-3-7T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2023-3-6T11:17
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1292
ending page: 1305
has place of publication: United States
has primary subject term: D013274Q000473
has subject term: D006801
has subject term: D051176Q000235Q000378
has subject term: D045744
has subject term: D002465Q000235
has subject term: D049109Q000235
has subject term: D002471Q000235
has subject term: D000071221Q000235Q000378
has subject term: D015972
has subject term: D014157Q000235Q000378
has subject term: D060449Q000235
source: Dig Dis Sci. 2023-04;68(4):1292-1305.
volume: 68

Arteriovenous malformation of the small intestine presenting with a transfusion-dependent anaemia in pregnancy.
pmid: 36889804
abstract: Gastrointestinal bleeding that originates in the small intestine is often difficult to diagnose. Bleeding from a small intestinal arteriovenous malformation (AVM) is rare, with congenital AVMs more commonly located in the rectum or sigmoid. There is a relative paucity of cases reported in the literature. In the gastrointestinal tract, it can cause acute and chronic bleeding, which can be fatal. Although the incidence of small bowel AVMs is quite low, such lesions can be identified as the bleeding source in patients with obscure gastrointestinal bleeding (OGIB) harbouring severe, transfusion-dependent anaemia. It can be exceedingly difficult to localise and diagnose gastrointestinal tract bleeding, particularly in cases of occult small bowel AVMs. CT angiography and capsule endoscopy can help to establish the diagnosis. Laparoscopy is an appropriate and beneficial treatment modality for small bowel resection. The authors present the case of a primigravida woman in her late 20s diagnosed with a symptomatic transfusion-dependent anaemia during her pregnancy. She developed OGIB and despite no history of chronic liver disease became encephalopathic. Due to her physical deterioration and uncertain diagnosis, her caesarean section was performed at 36+6 weeks to expedite investigations and treatment. She was diagnosed with a jejunal AVM and underwent coiled embolisation of her superior mesenteric artery. She became haemodynamically unstable and underwent a laparotomy and small bowel resection. A full non-invasive liver screen was negative, however, her MRI liver described multiple focal nodular hyperplasia (FNH) lesions raising the possibility of FNH syndrome in the context of a previous AVM malformation. A prompt stepwise, multimodality diagnostic approach is required to prevent patient morbidity and mortality.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/3/e251653
doi: 10.1136/bcr-2022-251653
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Dunphy L
      type: Person
      first name: Louise
      last name: Dunphy
      member of: Department of Obstetrics, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, UK Louise.Dunphy@doctors.org.uk.
  slot:
    index: 2
    item: Ford J
      type: Person
      first name: Jonathan
      last name: Ford
      member of: Department of Obstetrics, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, UK.
created: 2023-3-9T06:00
date last updated: 2025-03-09
issued: 2023-03-08
dp: 2023 Mar 08
created: 2023-3-8T20:42
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 3
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D000740Q000628Q000150
has primary subject term: D001165Q000175Q000000981
has subject term: D011247
has subject term: D006801
has subject term: D005260
has subject term: D002585Q000009
has subject term: D007421Q000473
has subject term: D006471Q000209Q000628Q000175
source: BMJ Case Rep. 2023-03-08;16(3):.
volume: 16

Feingold syndrome type 1: a rare cause of fetal microcephaly (prenatal diagnosis).
pmid: 36889805
abstract: We report a case of fetal microcephaly found during the second trimester ultrasound and confirmed by further ultrasound scans and fetal MRI. The array comparative genomic hybridisation analysis of the fetus and the male parent showed a 1.5 Mb deletion overlapping the Feingold syndrome region, an autosomal dominant syndrome that can cause microcephaly, facial/hand abnormalities, mild neurodevelopmental delay and others. This case illustrates the need for a detailed investigation by a multidisciplinary team to provide prenatal counselling regarding a postnatal outcome to the parents and orient their decision towards the continuation or termination of pregnancy.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/3/e254366
doi: 10.1136/bcr-2022-254366
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Gouveia I
      type: Person
      first name: Inês
      last name: Gouveia
      member of: Obstetrics and Gynecology, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Portugal inescfmgouveia@gmail.com.
  slot:
    index: 2
    item: Geraldo AF
      type: Person
      first name: Ana Filipa
      last name: Geraldo
      member of: Diagnostic Neuroradiology Unit, Radiology Department, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Portugal.
  slot:
    index: 3
    item: Godinho C
      type: Person
      first name: Cristina
      last name: Godinho
      member of: Obstetrics and Gynecology, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila Nova de Gaia, Portugal.
  slot:
    index: 4
    item: Castedo S
      type: Person
      first name: Sérgio
      last name: Castedo
      member of: Genetics Department of Faculty of Medicine, Universidade do Porto, Porto, Portugal.Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
created: 2023-3-9T06:00
date last updated: 2025-03-09
issued: 2023-03-08
dp: 2023 Mar 08
created: 2023-3-8T20:42
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 3
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D017880Q000235
has primary subject term: D008831Q000000981Q000235
has primary subject term: D008607Q000235
has subject term: D008297
has subject term: D005260
has subject term: D011247
has subject term: D006801
has subject term: D014138
has subject term: D016216
has subject term: D011296
has subject term: D005143Q000002
source: BMJ Case Rep. 2023-03-08;16(3):.
volume: 16

Peripapillary choroidal cavitation as a feature of pathological myopia.
pmid: 36889806
has PII: 16/3/e255072
doi: 10.1136/bcr-2023-255072
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Stephenson KAJ
      type: Person
      first name: Kirk A J
      last name: Stephenson
      member of: The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada kirkstephenson@hotmail.com.
  slot:
    index: 2
    item: Liu RT
      type: Person
      first name: Ruozhou Tom
      last name: Liu
      member of: The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada.
  slot:
    index: 3
    item: Mammo ZN
      type: Person
      first name: Zaid N
      last name: Mammo
      member of: The University of British Columbia Department of Ophthalmology & Visual Sciences, Vancouver, British Columbia, Canada.
created: 2023-3-9T06:00
date last updated: 2025-03-09
issued: 2023-03-08
dp: 2023 03 08
created: 2023-3-8T20:42
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 3
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D047728
has subject term: D006801
has subject term: D002829Q000000981
has subject term: D041623
source: BMJ Case Rep. 2023-03-08;16(3):.
volume: 16

Relationship Between Esophageal Disease and Pulmonary Fibrosis.
pmid: 36918450
abstract: Esophageal disorders are prevalent among patients with chronic lung diseases, including idiopathic pulmonary fibrosis (IPF). Gastroesophageal reflux disease (GERD) has been associated with IPF prevalence, severity, and respiratory decline. The pathophysiologic relationship between GERD and IPF is likely bidirectional, with aspiration of refluxate leading to lung inflammation and fibrosis, while the restrictive pulmonary physiology may contribute to altered transdiaphragmatic pressure gradient and increased reflux. Esophageal symptoms are frequently absent and do not predict esophageal dysfunction or pathologic reflux in patients with IPF, and objective diagnostic tools including upper endoscopy, ambulatory reflux monitoring, and high-resolution manometry are often needed. Impedance-based testing that identifies both weakly/non-acidic and acid reflux may provide important additional diagnostic value beyond pH-based acid testing alone. Novel metrics and maneuvers, including advanced impedance measures on impedance-pH study and provocative testing on HRM, may hold promise to future diagnostic advancements. The main treatment options include medical therapy with acid suppressants and anti-reflux surgery, although their potential benefits in pulmonary outcomes of IPF require further validations. Future directions of research include identifying phenotypes of IPF patients who may benefit from esophageal testing and treatment, determining the optimal testing strategy and protocol, and prospectively assessing the value of different esophageal therapies to improve outcomes while minimizing risks. This review will discuss the pathophysiology, evaluation, and management of esophageal diseases, particularly GERD, in patients with IPF, as informed by the most recent publications in the field, in hopes of identifying targets for future study and research.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10620-023-07908-2
doi: 10.1007/s10620-023-07908-2
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zhou JC
      type: Person
      first name: Joyce C
      last name: Zhou
      member of: Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.Harvard Medical School, Boston, MA, USA.
  slot:
    index: 2
    item: Gavini S
      type: Person
      first name: Sravanya
      last name: Gavini
      member of: Division of Digestive and Liver Diseases, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
  slot:
    index: 3
    item: Chan WW
      type: Person
      first name: Walter W
      last name: Chan
      member of: Harvard Medical School, Boston, MA, USA. wwchan@bwh.harvard.edu.Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. wwchan@bwh.harvard.edu.
  slot:
    index: 4
    item: Lo WK
      type: Person
      first name: Wai-Kit
      last name: Lo
      member of: Harvard Medical School, Boston, MA, USA.Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
created: 2023-3-16T06:00
date last updated: 2025-03-08
issued: 2023-04
dp: 2023 04
created: 2023-3-15T00:35
e ISSN: 1573-2568
has issn l: 0163-2116
issue: 4
has NLM journal title abbreviation: Dig Dis Sci
publication name: Digestive diseases and sciences
language: eng
has national library of medicine journal id: 7902782
derived from: NLM
starting page: 1096
ending page: 1105
has place of publication: United States
has primary subject term: D005764Q000150Q000175Q000453
has primary subject term: D054990Q000175Q000453Q000628
has primary subject term: D004942Q000150
has subject term: D006801
has subject term: D050782
has subject term: D008365
source: Dig Dis Sci. 2023-04;68(4):1096-1105.
volume: 68

Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate.
pmid: 37014788
abstract: Apolipoprotein E (ApoE)'s ϵ4 alle is the most important genetic risk factor for late onset Alzheimer's Disease (AD). Cell-surface heparan sulfate (HS) is a cofactor for ApoE/LRP1 interaction and the prion-like spread of tau pathology between cells. 3-O-sulfo (3-O-S) modification of HS has been linked to AD through its interaction with tau, and enhanced levels of 3-O-sulfated HS and 3-O-sulfotransferases in the AD brain. In this study, we characterized ApoE/HS interactions in wildtype ApoE3, AD-linked ApoE4, and AD-protective ApoE2 and ApoE3-Christchurch. Glycan microarray and SPR assays revealed that all ApoE isoforms recognized 3-O-S. NMR titration localized ApoE/3-O-S binding to the vicinity of the canonical HS binding motif. In cells, the knockout of HS3ST1-a major 3-O sulfotransferase-reduced cell surface binding and uptake of ApoE. 3-O-S is thus recognized by both tau and ApoE, suggesting that the interplay between 3-O-sulfated HS, tau and ApoE isoforms may modulate AD risk.
rights: © 2023 Wiley-VCH GmbH.
doi: 10.1002/anie.202212636
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Mah D
      type: Person
      first name: Dylan
      last name: Mah
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 2
    item: Zhu Y
      type: Person
      first name: Yanan
      last name: Zhu
      member of: Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani School of Medicine, Tampa, FL 33620, USA.
  slot:
    index: 3
    item: Su G
      type: Person
      first name: Guowei
      last name: Su
      member of: Glycan Therapeutics, Raleigh, NC 27606, USA.
  slot:
    index: 4
    item: Zhao J
      type: Person
      first name: Jing
      last name: Zhao
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.China Agricultural University, Beijing, 100083, China.
  slot:
    index: 5
    item: Canning A
      type: Person
      first name: Ashely
      last name: Canning
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 6
    item: Gibson J
      type: Person
      first name: James
      last name: Gibson
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 7
    item: Song X
      type: Person
      first name: Xuehong
      last name: Song
      member of: Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani School of Medicine, Tampa, FL 33620, USA.
  slot:
    index: 8
    item: Stancanelli E
      type: Person
      first name: Eduardo
      last name: Stancanelli
      member of: Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
  slot:
    index: 9
    item: Xu Y
      type: Person
      first name: Yongmei
      last name: Xu
      member of: Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
  slot:
    index: 10
    item: Zhang F
      type: Person
      first name: Fuming
      last name: Zhang
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 11
    item: Linhardt RJ
      type: Person
      first name: Robert J
      last name: Linhardt
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 12
    item: Liu J
      type: Person
      first name: Jian
      last name: Liu
      member of: Glycan Therapeutics, Raleigh, NC 27606, USA.Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA.
  slot:
    index: 13
    item: Wang L
      type: Person
      first name: Lianchun
      last name: Wang
      member of: Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani School of Medicine, Tampa, FL 33620, USA.
  slot:
    index: 14
    item: Wang C
      type: Person
      first name: Chunyu
      last name: Wang
      member of: Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
created: 2023-4-5T06:00
date last updated: 2025-03-09
issued: 2023-06-05
dp: 2023 06 05
created: 2023-4-4T12:53
e ISSN: 1521-3773
has issn l: 1433-7851
issue: 23
has NLM journal title abbreviation: Angew Chem Int Ed Engl
publication name: Angewandte Chemie (International ed. in English)
language: eng
has national library of medicine journal id: 0370543
derived from: NLM
pg: e202212636
has place of publication: Germany
has primary subject term: D000544Q000378
has subject term: D006801
has subject term: D053318Q000235
has subject term: D001057Q000737Q000235Q000378
has subject term: D006497Q000737
has subject term: D020033Q000378
source: Angew Chem Int Ed Engl. 2023-06-05;62(23):e202212636.
volume: 62

Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala.
pmid: 37076616
abstract: Stress is known to be a significant risk factor for the development of Major Depressive Disorder (MDD), yet the neural mechanisms that underlie this risk are poorly understood. Prior work has heavily implicated the corticolimbic system in the pathophysiology of MDD. In particular, the prefrontal cortex (PFC) and amygdala play a central role in regulating the response to stress, with dorsal PFC and ventral PFC exhibiting reciprocal excitatory and inhibitory influences on amygdala subregions. However, it remains unclear how best to disentangle the impact of stress from the impact of current MDD symptoms on this system. Here, we examined stress-induced changes in resting state functional connectivity (rsFC) within an a priori corticolimbic network in MDD patients and healthy controls (total n = 80) before and after an acute stressor or a no stress control condition. Using graph theoretic analysis, we found that connectivity between basolateral amygdala and dorsal prefrontal nodes of the corticolimbic network had a negative association with individual differences in chronic perceived stress at baseline. Following the acute stressor, healthy individuals showed a reduction of the amygdala node strength, while MDD patients exhibited little change. Finally, dorsal PFC-particularly dorsomedial PFC- connectivity to the basolateral amygdala was associated with the strength of the basolateral amygdala responses to loss feedback during a reinforcement learning task. These findings highlight attenuated connectivity between basolateral amygdala and prefrontal cortex in patients with MDD. In healthy individuals, acute stress exposure was found to push the corticolimbic network to a stress-phenotype that may be chronically present in patients with current depression and high levels of perceived stress. In sum, these results help to identify circuit mechanisms underlying the effects of acute stress and their role in mood disorders.
rights: © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
has PII: 10.1038/s41380-023-02056-5
doi: 10.1038/s41380-023-02056-5
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Hossein S
      type: Person
      first name: Shabnam
      last name: Hossein
      member of: Department of Psychology, Emory University, Atlanta, GA, USA.
  slot:
    index: 2
    item: Cooper JA
      type: Person
      first name: Jessica A
      last name: Cooper
      member of: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  slot:
    index: 3
    item: DeVries BAM
      type: Person
      first name: Brittany A M
      last name: DeVries
      member of: Department of Psychology, Emory University, Atlanta, GA, USA.
  slot:
    index: 4
    item: Nuutinen MR
      type: Person
      first name: Makiah R
      last name: Nuutinen
      member of: Department of Psychology, Emory University, Atlanta, GA, USA.
  slot:
    index: 5
    item: Hahn EC
      type: Person
      first name: Emma C
      last name: Hahn
      member of: Department of Psychology, Emory University, Atlanta, GA, USA.
  slot:
    index: 6
    item: Kragel PA
      type: Person
      first name: Philip A
      last name: Kragel
      member of: Department of Psychology, Emory University, Atlanta, GA, USA.
  slot:
    index: 7
    item: Treadway MT
      type: Person
      first name: Michael T
      last name: Treadway
      member of: Department of Psychology, Emory University, Atlanta, GA, USA. mtreadway@emory.edu.Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. mtreadway@emory.edu.
created: 2023-4-20T00:41
date last updated: 2025-03-09
issued: 2023-11
dp: 2023 Nov
created: 2023-04-19T23:23
e ISSN: 1476-5578
has issn l: 1359-4184
issue: 11
has NLM journal title abbreviation: Mol Psychiatry
publication name: Molecular psychiatry
language: eng
has national library of medicine journal id: 9607835
derived from: NLM
starting page: 4602
ending page: 4612
has place of publication: England
has primary subject term: D003865
has subject term: D006801
has subject term: D003863
has subject term: D008279
has subject term: D017397
has subject term: D000679
source: Mol Psychiatry. 2023-11;28(11):4602-4612.
volume: 28

Comparison of pulmonary congestion severity using artificial intelligence-assisted scoring versus clinical experts: A secondary analysis of BLUSHED-AHF.
pmid: 37218619
abstract: Acute decompensated heart failure (ADHF) is the leading cause of cardiovascular hospitalizations in the United States. Detecting B-lines through lung ultrasound (LUS) can enhance clinicians' prognostic and diagnostic capabilities. Artificial intelligence/machine learning (AI/ML)-based automated guidance systems may allow novice users to apply LUS to clinical care. We investigated whether an AI/ML automated LUS congestion score correlates with expert's interpretations of B-line quantification from an external patient dataset.This was a secondary analysis from the BLUSHED-AHF study which investigated the effect of LUS-guided therapy on patients with ADHF. In BLUSHED-AHF, LUS was performed and B-lines were quantified by ultrasound operators. Two experts then separately quantified the number of B-lines per ultrasound video clip recorded. Here, an AI/ML-based lung congestion score (LCS) was calculated for all LUS clips from BLUSHED-AHF. Spearman correlation was computed between LCS and counts from each of the original three raters. A total of 3858 LUS clips were analysed on 130 patients. The LCS demonstrated good agreement with the two experts' B-line quantification score (r = 0.894, 0.882). Both experts' B-line quantification scores had significantly better agreement with the LCS than they did with the ultrasound operator's score (p < 0.005, p < 0.001).Artificial intelligence/machine learning-based LCS correlated with expert-level B-line quantification. Future studies are needed to determine whether automated tools may assist novice users in LUS interpretation.
rights: © 2023 European Society of Cardiology.
doi: 10.1002/ejhf.2881
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Goldsmith AJ
      type: Person
      first name: Andrew J
      last name: Goldsmith
      member of: Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.Harvard Medical School, Boston, MA, USA.
  slot:
    index: 2
    item: Jin M
      type: Person
      first name: Mike
      last name: Jin
      member of: Centaur Labs, Boston, MA, USA.Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
  slot:
    index: 3
    item: Lucassen R
      type: Person
      first name: Ruben
      last name: Lucassen
      member of: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
  slot:
    index: 4
    item: Duggan NM
      type: Person
      first name: Nicole M
      last name: Duggan
      member of: Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.Harvard Medical School, Boston, MA, USA.
  slot:
    index: 5
    item: Harrison NE
      type: Person
      first name: Nicholas E
      last name: Harrison
      member of: Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 6
    item: Wells W
      type: Person
      first name: William
      last name: Wells
      member of: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
  slot:
    index: 7
    item: Ehrman RR
      type: Person
      first name: Robert R
      last name: Ehrman
      member of: Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
  slot:
    index: 8
    item: Ferre R
      type: Person
      first name: Robinson
      last name: Ferre
      member of: Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 9
    item: Gargani L
      type: Person
      first name: Luna
      last name: Gargani
      member of: Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
  slot:
    index: 10
    item: Noble V
      type: Person
      first name: Vicki
      last name: Noble
      member of: Department of Emergency Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.Department of Emergency Medicine, Case Western Reserve University, Cleveland, OH, USA.
  slot:
    index: 11
    item: Levy P
      type: Person
      first name: Phil
      last name: Levy
      member of: Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
  slot:
    index: 12
    item: Lane K
      type: Person
      first name: Katie
      last name: Lane
      member of: Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 13
    item: Li X
      type: Person
      first name: Xiaochun
      last name: Li
      member of: Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 14
    item: Collins S
      type: Person
      first name: Sean
      last name: Collins
      member of: Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  slot:
    index: 15
    item: Pang P
      type: Person
      first name: Peter
      last name: Pang
      member of: Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  slot:
    index: 16
    item: Kapur T
      type: Person
      first name: Tina
      last name: Kapur
      member of: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
  slot:
    index: 17
    item: Russell FM
      type: Person
      first name: Frances M
      last name: Russell
      member of: Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
created: 2023-5-23T13:05
date last updated: 2025-03-09
issued: 2023-07
dp: 2023 07
created: 2023-5-23T06:23
e ISSN: 1879-0844
has issn l: 1388-9842
issue: 7
has NLM journal title abbreviation: Eur J Heart Fail
publication name: European journal of heart failure
language: eng
has national library of medicine journal id: 100887595
derived from: NLM
starting page: 1166
ending page: 1169
has place of publication: England
has primary subject term: D006333Q000000981Q000150
has primary subject term: D011654Q000000981Q000209
has subject term: D006801
has subject term: D001185
has subject term: D008168Q000000981
has subject term: D014463Q000379
source: Eur J Heart Fail. 2023-07;25(7):1166-1169.
volume: 25

INTEREST 2022: new perspectives in HIV treatment, pathogenesis and prevention in Africa.
pmid: 37275773
has PII: 10.1177_20499361231177856
doi: 10.1177/20499361231177856
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Baluku JB
      type: Person
      first name: Joseph Baruch
      last name: Baluku
      member of: Kiruddu National Referral Hospital, Kampala, Uganda.Makerere University Lung Institute, Kampala, Uganda.
  slot:
    index: 2
    item: Torpey K
      type: Person
      first name: Kwasi
      last name: Torpey
      member of: University of Ghana School of Public Health, P.O Box LG 13, Legon, Accra, Ghana.Amsterdam Institute for Global Health & Development, Paasheuvelweg 25, 1105 BP Amsterdam, The Netherlands.
created: 2023-6-5T19:10
date last updated: 2025-03-09
created: 2023-6-5T12:21
ISSN: 2049-9361
has issn l: 2049-9361
has NLM journal title abbreviation: Ther Adv Infect Dis
publication name: Therapeutic advances in infectious disease
language: eng
has national library of medicine journal id: 101606715
derived from: NLM
pg: 20499361231177856
has place of publication: England
source: Ther Adv Infect Dis. ;10():20499361231177856.
volume: 10

http://rdf.ncbi.nlm.nih.gov/pubmed/37546235
pmid: 37546235
abstract: The diagnosis of cow's milk allergy (CMA) in infants and young children remains a challenge because many of the presenting symptoms are similar to those experienced in other diagnoses. Both over- and under-diagnosis occur frequently. Misdiagnosis carries allergic and nutritional risks, including acute reactions, growth faltering, micronutrient deficiencies and a diminished quality of life for infants and caregivers. An inappropriate diagnosis may also add a financial burden on families and on the healthcare system. Elimination and reintroduction of cow's milk (CM) and its derivatives is essential for diagnosing CMA as well as inducing tolerance to CM. In non-IgE mediated CMA, the diagnostic elimination diet typically requires 2-4 weeks before reintroduction, while for IgE mediated allergy the time window may be shorter (1-2 weeks). An oral food challenge (OFC) under medical supervision remains the most reliable diagnostic method for IgE mediated and more severe types of non-IgE mediated CMA such as food protein induced enterocolitis syndrome (FPIES). Conversely, for other forms of non-IgE mediated CMA, reintroduction can be performed at home. The OFC cannot be replaced by the milk ladder after a diagnostic elimination diet. The duration of the therapeutic elimination diet, once a diagnosis was confirmed, can only be established through testing changes in sensitization status, OFCs or home reintroduction, which are directed by local protocols and services' availability. Prior non-evidence-based recommendations suggest that the first therapeutic elimination diet should last for at least 6 months or up to the age of 9-12 months, whichever is reached first. After a therapeutic elimination diet, a milk-ladder approach can be used for non-IgE mediated allergies to determine tolerance. Whilst some centers use the milk ladder also for IgE mediated allergies, there are concerns about the risk of having immediate-type reactions at home. Milk ladders have been adapted to local[cell cut: 2350 characters, first 2000 kept]
rights: © 2023 The Author(s).
has PII: S1939-4551(23)00045-5
doi: 10.1016/j.waojou.2023.100785
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Meyer R
      type: Person
      first name: Rosan
      last name: Meyer
      member of: Faculty Medicine, Imperial College London, Department Nutrition and Dietetics, Winchester University, UK and Faculty Medicine, KU Leuven, Belgium.
  slot:
    index: 2
    item: Venter C
      type: Person
      first name: Carina
      last name: Venter
      member of: Children's Hospital Colorado, University of Colorado, Denver, CO, USA.
  slot:
    index: 3
    item: Bognanni A
      type: Person
      first name: Antonio
      last name: Bognanni
      member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Evidence in Allergy Group; Department of Medicine and Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 4
    item: Szajewska H
      type: Person
      first name: Hania
      last name: Szajewska
      member of: Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.
  slot:
    index: 5
    item: Shamir R
      type: Person
      first name: Raanan
      last name: Shamir
      member of: Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  slot:
    index: 6
    item: Nowak-Wegrzyn A
      type: Person
      first name: Anna
      last name: Nowak-Wegrzyn
      member of: Hassenfeld Children's Hospital, Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA.
  slot:
    index: 7
    item: Fiocchi A
      type: Person
      first name: Alessandro
      last name: Fiocchi
      member of: Allergy Unit - Area of Translational Research in Pediatric Specialities, Bambino Gesù Children's Hospital, Rome, Italy.
  slot:
    index: 8
    item: Vandenplas Y
      type: Person
      first name: Yvan
      last name: Vandenplas
      member of: Vrije Universiteit Brussel, UZ Brussel, KidZ Health Castle, Brussels, Belgium.
creator: WAO DRACMA Guideline Group
created: 2023-8-7T06:42
date last updated: 2025-03-09
issued: 2023-07
dp: 2023 Jul
created: 2023-8-7T04:34
ISSN: 1939-4551
has issn l: 1939-4551
issue: 7
has NLM journal title abbreviation: World Allergy Organ J
publication name: The World Allergy Organization journal
language: eng
has national library of medicine journal id: 101481283
derived from: NLM
pg: 100785
has place of publication: United States
source: World Allergy Organ J. 2023-07;16(7):100785.
title: World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guideline update - VII - Milk elimination and reintroduction in the diagnostic process of cow's milk allergy.
volume: 16

Change of sexual behavior among men who have sex with men before, during and after COVID-19 pandemic in China: a cross-sectional study.
pmid: 37563554
abstract: The COVID-19 epidemic control and prevention strategies affected people's sexual activities and behaviors. Little was known about long-term effects of COVID-19 prevention and control strategies on sexual behaviors among men who have sex with men (MSM). This study aimed to examine changes in risky sexual behaviors of MSM before and after the local epidemic.An online survey was conducted nationwide from June 1 to June 10, 2022. MSM aged 16 years and above, residing in China were recruited through convenience sampling. A generalized estimating equation model with modified Poisson regression was used to analyze changes in multiple sexual partners, unprotected sex, mobility for sexual activity, and recreational substance use before and after the local epidemic.Compared to the pre-pandemic (36.5%), the prevalence of multiple sexual partners (11.5%) significantly decreased during the local epidemic and then increased after the local epidemic (25.2%) but remained lower than pre-pandemic, as did the prevalence of unprotected sex (31.1%, 19.4%, and 26.1%), mobility for sexual activity (7.5%, 2.8%, and 4.1%) and recreational substance use (47.7%, 27.2%, and 39.5%). Compared to the pre-pandemic, higher declines in the prevalence of risky sexual behaviors during the local epidemic existed among MSM living without a regular partner (44% decrease in unprotected sex and 46% in recreational substance use), with a bachelor's degree and above (70% decrease in multiple sex partners, 39% in unprotected sex, 67% in mobility for sexual activity and 44% in recreational substance use), higher incomes (70% decrease in multiple sex partners), self-identified gay or bisexual/unsure (38-71%), and HIV infection (49-83% decrease respectively in these four indicators). After the local epidemic, the declines in the above indicators compared to the pre-pandemic were correspondingly. And higher declines existed among MSM living without a regular partner (8% decrease in unprotected sex and 13% in recr[cell cut: 2687 characters, first 2000 kept]
rights: © 2023. BioMed Central Ltd., part of Springer Nature.
has PII: 10.1186/s12879-023-08488-2
doi: 10.1186/s12879-023-08488-2
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Wang S
      type: Person
      first name: Shi
      last name: Wang
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  slot:
    index: 2
    item: Yang J
      type: Person
      first name: Jie
      last name: Yang
      member of: Shenlan Public Health Counsel Service Center, Tianjin, China.
  slot:
    index: 3
    item: Niu D
      type: Person
      first name: Dandan
      last name: Niu
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  slot:
    index: 4
    item: Hou Y
      type: Person
      first name: Yushan
      last name: Hou
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  slot:
    index: 5
    item: Fei L
      type: Person
      first name: Liping
      last name: Fei
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  slot:
    index: 6
    item: Zhao H
      type: Person
      first name: Hehe
      last name: Zhao
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
  slot:
    index: 7
    item: Chen F
      type: Person
      first name: Fangfang
      last name: Chen
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. chenfangfang@chinaaids.cn.
  slot:
    index: 8
    item: Lv F
      type: Person
      first name: Fan
      last name: Lv
      member of: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. fanlv@chinaaids.cn.
created: 2023-8-11T00:42
date last updated: 2025-03-09
issued: 2023-08-10
dp: 2023 Aug 10
created: 2023-8-10T23:39
e ISSN: 1471-2334
has issn l: 1471-2334
issue: 1
has NLM journal title abbreviation: BMC Infect Dis
publication name: BMC infectious diseases
language: eng
has national library of medicine journal id: 100968551
derived from: NLM
pg: 527
has place of publication: England
has primary subject term: D015658Q000453Q000517
has primary subject term: http://id.nlm.nih.gov/mesh/D000072339
has primary subject term: D000086382Q000453
has primary subject term: D019966Q000453
has subject term: D008297
has subject term: D006801
has subject term: D018451
has subject term: D003430
has subject term: D058873
has subject term: D012725
has subject term: D012747
has subject term: D002681Q000453
has subject term: D012309
source: BMC Infect Dis. 2023-08-10;23(1):527.
volume: 23

Unmet needs for modern contraceptive methods among sexually active adolescents and young women in Togo: a nationwide cross-sectional study.
pmid: 37575119
abstract: The unmet need for modern contraceptives among sexually active adolescent and young women (AYW) in Africa contributes to high morbidity and mortality. To investigate the prevalence of unmet need for modern contraceptives and its associated factors among AYW in Togo, we performed a secondary analysis of data from the MICS-62017 survey.We extracted data from sexually active AYW aged 15-24 years for the analysis and used multi-level logistic regression models to identify factors associated with unmet need for modern contraceptives.Among the AYW, the median age was 20 years. The prevalence of unmet need for modern contraceptives was 27.02%. Factors that increased the likelihood of having unmet need for contraceptives included being in the Poor or Middle quintile of household wealth, aged 20-24 years, and completing primary or secondary education. Living in a household headed by a woman and having a household head aged 19-38, 39-58, or greater than 78 years decreased the likelihood of unmet need for modern contraceptives.The study highlights the high-unmet need for modern contraceptives among sexually active AYW in Togo and emphasizes the importance of addressing individual and household/community factors to improve their sexual and reproductive health. Interventions such as increasing AYW awareness, providing social marketing campaigns in schools, and targeting men-headed households could help promote modern contraceptive use and improve the sexual and reproductive health of AYW in Togo.
rights: Copyright © 2023 Alidou, Dahourou, Dah, Sogo, Kenao, Yehadji, Meda and Ekouevi.
doi: 10.3389/fpubh.2023.1169180
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Alidou S
      type: Person
      first name: Smaila
      last name: Alidou
      member of: Département de Santé Publique, Unité de Formation et de Recherche en Sciences de la Santé, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.Ministère de la Santé, Hygiène Publique et de l'Accès Universel aux Soins, Lomé, Togo.
  slot:
    index: 2
    item: Dahourou LD
      type: Person
      first name: Lucien Désiré
      last name: Dahourou
      member of: Institut de Recherche en Sciences de la Santé (IRSS/CNRST), Ouagadougou, Burkina Faso.Institut National de la Santé et de la Recherche Médicale (INSERM, UMR1295), Centre d'épidémiologie et de Recherche en Santé des Populations (CERPOP), Université de Toulouse, Toulouse, France.
  slot:
    index: 3
    item: Dah TTE
      type: Person
      first name: Ter Tiero Elias
      last name: Dah
      member of: Unité de Formation et de Recherche en Sciences de la Santé, Université de Ouahigouya, Ouahigouya, Burkina Faso.
  slot:
    index: 4
    item: Sogo A
      type: Person
      first name: Armel
      last name: Sogo
      member of: Institut de Recherche en Sciences de la Santé (IRSS/CNRST), Ouagadougou, Burkina Faso.
  slot:
    index: 5
    item: Kenao TS
      type: Person
      first name: Tchasso Serge
      last name: Kenao
      member of: Département de Promotion de la Santé, Institut Régionale de Santé Publique, Université d'Abomey-Calavi, Cotonou, Benin.
  slot:
    index: 6
    item: Yehadji D
      type: Person
      first name: Dègninou
      last name: Yehadji
      member of: Ministère de la Santé, Hygiène Publique et de l'Accès Universel aux Soins, Lomé, Togo.
  slot:
    index: 7
    item: Meda N
      type: Person
      first name: Nicolas
      last name: Meda
      member of: Département de Santé Publique, Unité de Formation et de Recherche en Sciences de la Santé, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
  slot:
    index: 8
    item: Ekouevi DK
      type: Person
      first name: Didier Koumavi
      last name: Ekouevi
      member of: Département de Santé Publique, Faculté des Sciences de la Santé (FSS), Université de Lomé, Lomé, Togo.
created: 2023-8-14T06:42
date last updated: 2025-03-09
issued: 2023
dp: 2023
created: 2023-8-14T04:24
e ISSN: 2296-2565
has issn l: 2296-2565
has NLM journal title abbreviation: Front Public Health
publication name: Frontiers in public health
language: eng
has national library of medicine journal id: 101616579
derived from: NLM
pg: 1169180
has place of publication: Switzerland
has primary subject term: D003267
has primary subject term: D003270
has subject term: D005260
has subject term: D000293
has subject term: D006801
has subject term: D055815
has subject term: D000328
has subject term: D003430
has subject term: D014037
has subject term: D012725
source: Front Public Health. 2023;11():1169180.
volume: 11

Spanish Pediatricians' Positions Regarding Prevention, Diagnosis, Nutritional Management, and Challenges in Cow's Milk Protein Allergy.
pmid: 37630776
abstract: Management of cow's milk protein allergy (CMPA) can vary depending on the experience and area of expertise of the clinician responsible for the patient's follow-up, which may or may not align with the recently published literature. To analyze the perspectives of Spanish pediatricians on this topic, a survey was conducted. The survey aimed to determine the current opinions and attitudes of 222 primary care and hospital pediatricians toward CMPA prevention and nutritional management. Participating pediatricians completed the questionnaire, providing insights into their daily clinical practices, including access to testing, attitudes with respect to various aspects of CMPA diagnosis, prevention, oral food challenges, and treatment. The findings revealed that pediatricians generally agree on the use of extensively hydrolyzed formulas (eHFs) to prevent CMPA in high-risk atopic children, despite limited evidence supporting the widespread use of this practice. However, consensus was lacking regarding the utility of formulas with prebiotics and probiotics for expediting tolerance development. In most cases, pediatricians preferred eHFs for the nutritional management of CMPA, followed by hydrolyzed rice formulas (HRFs), with amino-acid-based formulas (AAFs) being the third option. Certain issues remained controversial among pediatricians, such as prevention methods, symptom assessment, and the role of probiotics. These variations in management approaches reflect the influence of clinician experience and area of expertise, underscoring the need for standardized guidelines in this field.
has PII: nu15163586
doi: 10.3390/nu15163586
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Martín-Masot R
      type: Person
      first name: Rafael
      last name: Martín-Masot
      member of: Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, 29011 Málaga, Spain.
  slot:
    index: 2
    item: Díaz-Martín JJ
      type: Person
      first name: Juan José
      last name: Díaz-Martín
      member of: Pediatric Gastroenterology and Nutrition Unit, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
  slot:
    index: 3
    item: Santamaría-Orleans A
      type: Person
      first name: Alicia
      last name: Santamaría-Orleans
      member of: Laboratorios Ordesa S.L., Scientific Communication Department, 08830 Sant Boi del Llobregat, Spain.
  slot:
    index: 4
    item: Navas-López VM
      type: Person
      first name: Víctor Manuel
      last name: Navas-López
      member of: Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, 29011 Málaga, Spain.
created: 2023-8-26T10:45
date last updated: 2025-03-09
issued: 2023-08-15
dp: 2023 Aug 15
created: 2023-8-26T01:27
e ISSN: 2072-6643
has issn l: 2072-6643
issue: 16
has NLM journal title abbreviation: Nutrients
publication name: Nutrients
language: eng
has national library of medicine journal id: 101521595
derived from: NLM
has place of publication: Switzerland
has primary subject term: D016269Q000175Q000517
has subject term: D000818
has subject term: D002417
has subject term: D005260
has subject term: D006801
has subject term: D015073
has subject term: D000596
has subject term: http://id.nlm.nih.gov/mesh/D000072143
has subject term: D056692
source: Nutrients. 2023-08-15;15(16):.
volume: 15

Exploring health insurance and knowledge of the ovulatory cycle: evidence from Demographic and Health Surveys of 29 countries in Sub-Saharan Africa.
pmid: 37649040
abstract: Unplanned pregnancy continues to be a major public health concern in Sub-Saharan Africa (SSA). Understanding the ovulatory cycle can help women avoid unplanned pregnancy. Though a wide range of factors for ovulatory cycle knowledge in SSA countries has not been well assessed, the influence of health insurance on ovulatory cycle knowledge is largely unknown. As a result, we set out to investigate the relationship between health insurance enrollment and knowledge of the ovulatory cycle among women of childbearing age. This study aims to investigate the relationship between health insurance enrollment and knowledge of the ovulatory cycle among women of childbearing age in sub-Saharan Africa (SSA).Demographic and Health Surveys (DHSs) data from 29 SSA countries were analyzed. The association between health insurance and ovulatory cycle knowledge was investigated using bivariate and multivariate multilevel logistic regression models among 372,692 women of reproductive age (15-49). The findings were presented as adjusted odds ratios (AOR) with 95% confidence intervals (CI). A p-value of 0.05 was considered statistically significant.The pooled result shows that the prevalence of knowledge of ovulatory cycle in the studied 29 SSA countries was 25.5% (95% CI; 24.4%-26.6%). Findings suggest higher odds of ovulatory cycle knowledge among women covered by health insurance (AOR = 1.27, 95% CI; 1.02-1.57), with higher education (higher-AOR = 2.83, 95% CI; 1.95-4.09), from the richest wealth quintile (richest-AOR = 1.39, 95% CI; 1.04-1.87), and from female headed households (AOR = 1.16, 95% CI; 1.01-1.33) compared to women who had no formal education, were from the poorest wealth quintile and belonged to male headed households, respectively. We found lower odds of ovulatory cycle knowledge among women who had 2-4 parity history (AOR = 0.80, 95% CI; 0.65-0.99) compared to those with history of one parity.The findings indicate that the knowledge of the ovulatory cycle is lacking in [cell cut: 2460 characters, first 2000 kept]
rights: © 2023. BioMed Central Ltd., part of Springer Nature.
has PII: 10.1186/s12978-023-01675-z
doi: 10.1186/s12978-023-01675-z
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zegeye B
      type: Person
      first name: Betregiorgis
      last name: Zegeye
      member of: HaSET Maternal and Child Health Research Program, Addis Ababa, Ethiopia.
  slot:
    index: 2
    item: Idriss-Wheeler D
      type: Person
      first name: Dina
      last name: Idriss-Wheeler
      member of: Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Canada.
  slot:
    index: 3
    item: Oladimeji O
      type: Person
      first name: Olanrewaju
      last name: Oladimeji
      member of: Faculty of Health Sciences, Department of Public Health, Walter Sisulu University, Eastern Cape, Mthatha, South Africa.
  slot:
    index: 4
    item: Yaya S
      type: Person
      first name: Sanni
      last name: Yaya
      member of: School of International Development and Global Studies, University of Ottawa, Ottawa, Canada. sanni.yaya@uottawa.ca.The George Institute for Global Health, Imperial College London, London, UK. sanni.yaya@uottawa.ca.
created: 2023-8-31T00:42
date last updated: 2025-03-09
issued: 2023-08-30
dp: 2023 Aug 30
created: 2023-8-30T23:41
e ISSN: 1742-4755
has issn l: 1742-4755
issue: 1
has NLM journal title abbreviation: Reprod Health
publication name: Reproductive health
language: eng
has national library of medicine journal id: 101224380
derived from: NLM
pg: 129
has place of publication: England
has primary subject term: D007348
has subject term: D011247
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D055361
has subject term: D016017
has subject term: D010298
has subject term: D018873
source: Reprod Health. 2023-08-30;20(1):129.
volume: 20

Post-embryonic endogenous expression and localization of LET-60/Ras in C. elegans.
pmid: 37692087
abstract: Ras GTPases regulate many developmental and physiological processes and mutations in Ras are associated with numerous human cancers. Here, we report the function, levels, and localization of an N-terminal knock-in of mNeonGreen (mNG) into C. elegans LET-60 /Ras. mNG:: LET-60 interferes with some but not all LET-60 /Ras functions. mNG:: LET-60 is broadly present in tissues, found at different levels in cells, and concentrates in distinct subcellular compartments, including the nucleolus, nucleus, intracellular region, and plasma membrane. These results suggest that mNG:: LET-60 can be a useful tool for determining LET-60 levels and localization once its functionality in a developmental or physiological process is established.
rights: Copyright: © 2023 by the authors.
doi: 10.17912/micropub.biology.000931
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Jayadev R
      type: Person
      first name: Ranjay
      last name: Jayadev
      member of: Department of Biology, Duke University, Durham, NC, USA.
  slot:
    index: 2
    item: Chi Q
      type: Person
      first name: Qiuyi
      last name: Chi
      member of: Department of Biology, Duke University, Durham, NC, USA.
  slot:
    index: 3
    item: Sherwood DR
      type: Person
      first name: David R
      last name: Sherwood
      member of: Department of Biology, Duke University, Durham, NC, USA.
created: 2023-9-11T06:42
date last updated: 2025-03-09
issued: 2023
dp: 2023
created: 2023-9-11T04:32
e ISSN: 2578-9430
has issn l: 2578-9430
has NLM journal title abbreviation: MicroPubl Biol
publication name: microPublication biology
language: eng
has national library of medicine journal id: 101759238
derived from: NLM
has place of publication: United States
source: MicroPubl Biol. 2023;2023():.
volume: 2023

Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis Through Restoring Gut Microbiota and Metabolites.
pmid: 37704113
abstract: Pien Tze Huang (PZH) is a well-established traditional medicine with beneficial effects against inflammation and cancer. We aimed to explore the chemopreventive effect of PZH in colorectal cancer (CRC) through modulating gut microbiota.CRC mouse models were established by azoxymethane plus dextran sulfate sodium treatment or in Apcmin/+ mice treated with or without PZH (270 mg/kg and 540 mg/kg). Gut barrier function was determined by means of intestinal permeability assays and transmission electron microscopy. Fecal microbiota and metabolites were analyzed by means of metagenomic sequencing and liquid chromatography mass spectrometry, respectively. Germ-free mice or antibiotic-treated mice were used as models of microbiota depletion.PZH inhibited colorectal tumorigenesis in azoxymethane plus dextran sulfate sodium-treated mice and in Apcmin/+ mice in a dose-dependent manner. PZH treatment altered the gut microbiota profile, with an increased abundance of probiotics Pseudobutyrivibrio xylanivorans and Eubacterium limosum, while pathogenic bacteria Aeromonas veronii, Campylobacter jejuni, Collinsella aerofaciens, and Peptoniphilus harei were depleted. In addition, PZH increased beneficial metabolites taurine and hypotaurine, bile acids, and unsaturated fatty acids, and significantly restored gut barrier function. Transcriptomic profiling revealed that PZH inhibited PI3K-Akt, interleukin-17, tumor necrosis factor, and cytokine-chemokine signaling. Notably, the chemopreventive effect of PZH involved both microbiota-dependent and -independent mechanisms. Fecal microbiota transplantation from PZH-treated mice to germ-free mice partly recapitulated the chemopreventive effects of PZH. PZH components ginsenoside-F2 and ginsenoside-Re demonstrated inhibitory effects on CRC cells and primary organoids, and PZH also inhibited tumorigenesis in azoxymethane plus dextran sulfate sodium-treated germ-free mice.PZH manipulated gut microbiota and metabolites toward a more favorable pr[cell cut: 2140 characters, first 2000 kept]
rights: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S0016-5085(23)04982-X
doi: 10.1053/j.gastro.2023.08.052
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Gou H
      type: Person
      first name: Hongyan
      last name: Gou
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 2
    item: Su H
      type: Person
      first name: Hao
      last name: Su
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 3
    item: Liu D
      type: Person
      first name: Dehua
      last name: Liu
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 4
    item: Wong CC
      type: Person
      first name: Chi Chun
      last name: Wong
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 5
    item: Shang H
      type: Person
      first name: Haiyun
      last name: Shang
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 6
    item: Fang Y
      type: Person
      first name: Yi
      last name: Fang
      member of: Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 7
    item: Zeng X
      type: Person
      first name: Xianyi
      last name: Zeng
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 8
    item: Chen H
      type: Person
      first name: Huarong
      last name: Chen
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China; Department of Anesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  slot:
    index: 9
    item: Li Y
      type: Person
      first name: Yan
      last name: Li
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 10
    item: Huang Z
      type: Person
      first name: Ziheng
      last name: Huang
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 11
    item: Fan M
      type: Person
      first name: Miao
      last name: Fan
      member of: Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 12
    item: Wei C
      type: Person
      first name: Chunxian
      last name: Wei
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 13
    item: Wang X
      type: Person
      first name: Xin
      last name: Wang
      member of: Department of Pathology, the First Hospital of Hebei Medical University, Hebei, China.
  slot:
    index: 14
    item: Zhang X
      type: Person
      first name: Xiang
      last name: Zhang
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China.
  slot:
    index: 15
    item: Li X
      type: Person
      first name: Xiaoxing
      last name: Li
      member of: Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 16
    item: Yu J
      type: Person
      first name: Jun
      last name: Yu
      member of: Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shenzhen Research Institute, Hong Kong Special Administrative Region, China. Electronic address: junyu@cuhk.edu.hk.
created: 2023-9-14T00:42
date last updated: 2025-03-09
issued: 2023-12
dp: 2023 12
created: 2023-9-13T19:17
e ISSN: 1528-0012
has issn l: 0016-5085
issue: 6
has NLM journal title abbreviation: Gastroenterology
publication name: Gastroenterology
language: eng
has national library of medicine journal id: 0374630
derived from: NLM
starting page: 1404
ending page: 1419
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000069196
has primary subject term: D015179Q000139Q000517Q000378
has subject term: D051379
has subject term: D000818
has subject term: D015398
has subject term: D016264Q000633
has subject term: D019869Q000378
has subject term: D017209
has subject term: D008519
has subject term: D063646
has subject term: D001397Q000633
source: Gastroenterology. 2023-12;165(6):1404-1419.
volume: 165

Investigating Pseudomonas aeruginosa Gene Function During Pathogenesis Using Mobile-CRISPRi.
pmid: 37819512
abstract: CRISPR interference (CRISPRi) is a robust gene silencing technique that is ideal for targeting essential and conditionally essential (CE) genes. CRISPRi is especially valuable for investigating gene function in pathogens such as P. aeruginosa where essential and CE genes underlie clinically important phenotypes such as antibiotic susceptibility and virulence. To facilitate the use of CRISPRi in diverse bacteria-including P. aeruginosa-we developed a suite of modular, mobilizable, and integrating vectors we call, Mobile-CRISPRi. We further optimized Mobile-CRISPRi for use in P. aeruginosa mouse models of acute lung infection by expressing the CRISPRi machinery at low levels constitutively, enabling partial knockdown of essential and CE genes without the need for an exogenous inducer. Here, we describe protocols for creating Mobile-CRISPRi knockdown strains and testing their phenotypes in a mouse pneumonia model of P. aeruginosa infection. In addition, we provide comprehensive guide RNA designs to target genes in common laboratory strains of P. aeruginosa and other Pseudomonas species.
rights: © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
doi: 10.1007/978-1-0716-3473-8_2
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Yu MA
      type: Person
      first name: Michelle A
      last name: Yu
      member of: Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
  slot:
    index: 2
    item: Banta AB
      type: Person
      first name: Amy B
      last name: Banta
      member of: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI, USA.
  slot:
    index: 3
    item: Ward RD
      type: Person
      first name: Ryan D
      last name: Ward
      member of: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA.
  slot:
    index: 4
    item: Prasad NK
      type: Person
      first name: Neha K
      last name: Prasad
      member of: Chan Zuckerberg Biohub, San Francisco, CA, USA.Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  slot:
    index: 5
    item: Kwon MS
      type: Person
      first name: Michael S
      last name: Kwon
      member of: Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
  slot:
    index: 6
    item: Rosenberg OS
      type: Person
      first name: Oren S
      last name: Rosenberg
      member of: Chan Zuckerberg Biohub, San Francisco, CA, USA.Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
  slot:
    index: 7
    item: Peters JM
      type: Person
      first name: Jason M
      last name: Peters
      member of: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA. jason.peters@wisc.edu.Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin-Madison, Madison, WI, USA. jason.peters@wisc.edu.Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. jason.peters@wisc.edu.Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA. jason.peters@wisc.edu.
created: 2023-10-11T14:43
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2023-10-11T11:11
e ISSN: 1940-6029
has issn l: 1064-3745
has NLM journal title abbreviation: Methods Mol Biol
publication name: Methods in molecular biology (Clifton, N.J.)
language: eng
has national library of medicine journal id: 9214969
derived from: NLM
starting page: 13
ending page: 32
has place of publication: United States
has primary subject term: D011550Q000235
has primary subject term: D064113
has subject term: D000818
has subject term: D051379
has subject term: D064112
has subject term: D020868
has subject term: D010641
source: Methods Mol Biol. 2024;2721():13-32.
volume: 2721

Tolerance development in non-IgE mediated food allergies: lessons from Brazil.
pmid: 37858601
has PII: S0021-7557(23)00119-5
doi: 10.1016/j.jped.2023.10.001
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Venter C
      type: Person
      first name: Carina
      last name: Venter
      member of: University of Colorado School of Medicine, Department of Pediatrics, Section of Allergy & Immunology, Colorado, USA; Children's Hospital Colorado, Colorado, USA. Electronic address: carina.venter@childrenscolorado.org.
  slot:
    index: 2
    item: Vieira MC
      type: Person
      first name: Mario C
      last name: Vieira
      member of: Hospital Pequeno Príncipe, Centro de Gastroenterologia Pediátrica, Curitiba, PR, Brazil.
  slot:
    index: 3
    item: Fleischer D
      type: Person
      first name: David
      last name: Fleischer
      member of: University of Colorado School of Medicine, Department of Pediatrics, Section of Allergy & Immunology, Colorado, USA; Children's Hospital Colorado, Colorado, USA.
created: 2023-10-20T06:42
date last updated: 2025-03-09
created: 2023-10-20T00:29
e ISSN: 1678-4782
has issn l: 0021-7557
issue: 1
has NLM journal title abbreviation: J Pediatr (Rio J)
publication name: Jornal de pediatria
language: eng
has national library of medicine journal id: 2985188R
derived from: NLM
starting page: 4
ending page: 7
has place of publication: Brazil
has primary subject term: D005512
has subject term: D006801
has subject term: D001938
has subject term: D007108
has subject term: D000485
source: J Pediatr (Rio J). ;100(1):4-7.
volume: 100

Fertility counseling guide for transgender and gender diverse people.
pmid: 37901065
has PII: 2257062
doi: 10.1080/26895269.2023.2257062
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Stolk THR
      type: Person
      first name: T H R
      last name: Stolk
      member of: Amsterdam UMC, location Vrije Universiteit Amsterdam, Center of Expertise on Gender Dysphoria, Amsterdam University Medical Centers, Amsterdam, The Netherlands.Department of Obstetrics & Gynaecology, Amsterdam UMC, Amsterdam, The Netherlands.Amsterdam Reproduction and Development, Amsterdam, The Netherlands.
  slot:
    index: 2
    item: van den Boogaard E
      type: Person
      first name: E
      last name: van den Boogaard
      member of: Amsterdam UMC, location Vrije Universiteit Amsterdam, Center of Expertise on Gender Dysphoria, Amsterdam University Medical Centers, Amsterdam, The Netherlands.Department of Obstetrics & Gynaecology, Amsterdam UMC, Amsterdam, The Netherlands.Amsterdam Reproduction and Development, Amsterdam, The Netherlands.
  slot:
    index: 3
    item: Huirne JAF
      type: Person
      first name: J A F
      last name: Huirne
      member of: Department of Obstetrics & Gynaecology, Amsterdam UMC, Amsterdam, The Netherlands.Amsterdam Reproduction and Development, Amsterdam, The Netherlands.
  slot:
    index: 4
    item: van Mello NM
      type: Person
      first name: N M
      last name: van Mello
      member of: Amsterdam UMC, location Vrije Universiteit Amsterdam, Center of Expertise on Gender Dysphoria, Amsterdam University Medical Centers, Amsterdam, The Netherlands.Department of Obstetrics & Gynaecology, Amsterdam UMC, Amsterdam, The Netherlands.Amsterdam Reproduction and Development, Amsterdam, The Netherlands.
created: 2023-10-30T06:46
date last updated: 2025-03-09
issued: 2023
dp: 2023
created: 2023-10-30T04:44
e ISSN: 2689-5277
has issn l: 2689-5269
issue: 4
has NLM journal title abbreviation: Int J Transgend Health
publication name: International journal of transgender health
language: eng
has national library of medicine journal id: 101765532
derived from: NLM
starting page: 361
ending page: 367
has place of publication: United States
source: Int J Transgend Health. 2023;24(4):361-367.
volume: 24

Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
pmid: 37945820
abstract: Regulatory T (Treg) cell modulation of adaptive immunity and tissue homeostasis is well described; however, less is known about Treg cell-mediated regulation of the innate immune response. Here we show that deletion of ST2, the receptor for interleukin (IL)-33, on Treg cells increased granulocyte influx into the lung and increased cytokine production by innate lymphoid and γδ T cells without alteration of adaptive immunity to influenza. IL-33 induced high levels of the interleukin-1 receptor antagonist (IL-1Ra) in ST2+ Treg cells and deletion of IL-1Ra in Treg cells increased granulocyte influx into the lung. Treg cell-specific deletion of ST2 or IL-1Ra improved survival to influenza, which was dependent on IL-1. Adventitial fibroblasts in the lung expressed high levels of the IL-1 receptor and their chemokine production was suppressed by Treg cell-produced IL-1Ra. Thus, we define a new pathway where IL-33-induced IL-1Ra production by tissue Treg cells suppresses IL-1-mediated innate immune responses to respiratory viral infection.
rights: © 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
has PII: 10.1038/s41590-023-01655-2
doi: 10.1038/s41590-023-01655-2
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Griffith JW
      type: Person
      first name: Jason W
      last name: Griffith
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 2
    item: Faustino LD
      type: Person
      first name: Lucas D
      last name: Faustino
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 3
    item: Cottrell VI
      type: Person
      first name: Victoria I
      last name: Cottrell
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 4
    item: Nepal K
      type: Person
      first name: Keshav
      last name: Nepal
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 5
    item: Hariri LP
      type: Person
      first name: Lida P
      last name: Hariri
      member of: Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  slot:
    index: 6
    item: Chiu RS
      type: Person
      first name: Rebecca Suet-Yan
      last name: Chiu
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 7
    item: Jones MC
      type: Person
      first name: Michael C
      last name: Jones
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 8
    item: Julé A
      type: Person
      first name: Amélie
      last name: Julé
      member of: Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  slot:
    index: 9
    item: Gabay C
      type: Person
      first name: Cem
      last name: Gabay
      member of: Division of Rheumatology, University Hospitals of Geneva and University of Geneva Faculty of Medicine, Geneva, Switzerland.
  slot:
    index: 10
    item: Luster AD
      type: Person
      first name: Andrew D
      last name: Luster
      member of: Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. aluster@mgh.harvard.edu.Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. aluster@mgh.harvard.edu.
created: 2023-11-10T00:44
date last updated: 2025-03-09
issued: 2023-12
dp: 2023 Dec
created: 2023-11-9T23:48
e ISSN: 1529-2916
has issn l: 1529-2908
issue: 12
has NLM journal title abbreviation: Nat Immunol
publication name: Nature immunology
language: eng
has national library of medicine journal id: 100941354
derived from: NLM
starting page: 2091
ending page: 2107
has place of publication: United States
has primary subject term: D007251
has primary subject term: D050378
has subject term: D006801
has subject term: D007113
has subject term: D053590
has subject term: D007375Q000235
has subject term: D000072179Q000235
has subject term: D000067596Q000378
has subject term: D008214Q000378
has subject term: D000818
has subject term: D051379
source: Nat Immunol. 2023-12;24(12):2091-2107.
volume: 24

Early Introduction of Novel and Less-Studied Food Allergens in the Plant-Based Era: Considerations for US and EU Infant Formula Regulations.
pmid: 37960183
abstract: Early life feeding practices may affect the long-term health of individuals, particularly in terms of the development of non-communicable diseases, such as metabolic and allergic diseases. Accumulating evidence suggests that the interplay of breastfeeding and/or formula feeding followed by the introduction of solids plays a role in the occurrence of non-communicable diseases both in the short and long term. International food allergy guidelines recommend that breastfeeding women do not need to avoid food allergens and do not recommend any infant formula for allergy prevention. Guidelines regarding solid food introduction for food allergy prevention recommend the introduction of well-cooked eggs and peanuts around 4-6 months of age, and not to delay the introduction of other food allergens. There is also an increasing trend to feed infants a plant-based or plant-forward diet and have access to infant formulas based on plant-based ingredients. The use of novel plant-based infant formulas raises a few questions reviewed in this paper: (1) Do fortified, plant-based infant formulas, compliant with US Food and Drug Administration (FDA) regulations and European Food Safety Authority (EFSA) (European) guidelines, support adequate infant growth? (2) Are plant-based infant formulas suitable for the management of cow's milk allergy? (3) Does feeding with novel, plant-based infant formulas increase the risk of food allergies to the food allergens they contain? (4) Does feeding infants plant-based food allergens in early life increase the risk of allergic and severe allergic reactions? The review of the literature indicated that (1) plant-based formulas supplemented with amino acids and micronutrients to comply with FDA regulations and EFSA guidelines, evaluated in sufficiently powered growth studies, can support adequate growth in infants; (2) currently available plant-based infant formulas are suitable for the management of CMA; (3) an early introduction and continuous intake [cell cut: 2162 characters, first 2000 kept]
has PII: nu15214530
doi: 10.3390/nu15214530
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Venter C
      type: Person
      first name: Carina
      last name: Venter
      member of: University of Colorado/Children's Hospital Colorado: Section of Pediatric Allergy and Clinical Immunology, Aurora, CO 80045, USA.
  slot:
    index: 2
    item: Shamir R
      type: Person
      first name: Raanan
      last name: Shamir
      member of: Institute for Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center of Israel, Faculty of Medicine, Tel Aviv University, Tel Aviv 74071-12-20, Israel.
  slot:
    index: 3
    item: Fleischer DM
      type: Person
      first name: David Mark
      last name: Fleischer
      member of: University of Colorado/Children's Hospital Colorado: Section of Pediatric Allergy and Clinical Immunology, Aurora, CO 80045, USA.
created: 2023-11-14T06:42
date last updated: 2025-03-09
issued: 2023-10-25
dp: 2023 Oct 25
created: 2023-11-14T02:18
e ISSN: 2072-6643
has issn l: 2072-6643
issue: 21
has NLM journal title abbreviation: Nutrients
publication name: Nutrients
language: eng
has national library of medicine journal id: 101521595
derived from: NLM
has place of publication: Switzerland
has primary subject term: http://id.nlm.nih.gov/mesh/D000073296
has primary subject term: D005512Q000517
has primary subject term: D016269Q000517
has subject term: D007223
has subject term: D000818
has subject term: D002417
has subject term: D006801
has subject term: D005260
has subject term: D041943Q000737
has subject term: D001942
has subject term: D000485
has subject term: D007225
source: Nutrients. 2023-10-25;15(21):.
volume: 15

Cow's Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6-12 months: a cross-sectional study.
pmid: 37973640
abstract: The Cow's Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating cow's milk-related symptoms. Previous studies have focused on providing CoMiSS values for healthy and symptomatic infants aged 0-6 months. However, there is a notable gap in the literature concerning CoMiSS values for infants older than 6 months. This cross-sectional study aimed to determine CoMiSS values in presumed healthy infants who have completed 6 months and are up to 12 months old, hereafter referred to as 6 to 12 months old. Physicians from six European countries prospectively determined CoMiSS values in infants attending well-child clinics. Exclusion criteria included preterm delivery, acute or chronic disease, and the consumption of a therapeutic formula, dietary supplements (except vitamins), or medication. The following information was collected: gestational age, gender, age, type of feed (breast milk or infant formula), and complementary feeding. Descriptive statistics were summarized with mean and standard deviation for normally distributed continuous variables, median and IQR for non-normally distributed variables, and differences in CoMiSS values were analyzed with appropriate tests. Data from 609 infants were obtained. The overall median (Q1-Q3) CoMiSS values were 3 (1-5). Significant differences were found across age groups (p < 0.001), but not across groups based on gender (p = 0.551) or feeding type (p = 0.880). Conclusions: This study provided CoMiSS values in presumed healthy infants aged 6-12 months. Additional studies should be conducted to establish the use of CoMiSS to assess cow's milk-related symptoms in infants 6 months and older. What is Known: • The Cow's Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating symptoms related to cow's milk. • CoMiSS values for presumed healthy infants aged 0-6 months infants are already available. What is New: • CoMiSS values in European infants aged 6-12 months are provided. • These CoMiSS values differe[cell cut: 2082 characters, first 2000 kept]
rights: © 2023. The Author(s).
has PII: 10.1007/s00431-023-05334-0
doi: 10.1007/s00431-023-05334-0
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Jankiewicz M
      type: Person
      first name: Mateusz
      last name: Jankiewicz
      member of: Department of Paediatrics, The Medical University of Warsaw, Żwirki I Wigury 63A, 02-091, Warsaw, Poland.
  slot:
    index: 2
    item: Ahmed F
      type: Person
      first name: Fatme
      last name: Ahmed
      member of: Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, Varna, Bulgaria.Research Group NutriLect, Department of Neuroscience, Research Institute, Medical University Prof. Dr. Paraskev Stoyanov , Varna, Bulgaria.
  slot:
    index: 3
    item: Bajerova K
      type: Person
      first name: Katerina
      last name: Bajerova
      member of: Department of Pediatrics, University Hospital Brno and Masaryk's University, Brno, Czech Republic.Department of Internal Medicine, Geriatrics and Practical Medicine, University Hospital Brno and Masaryk´S University, Brno, Czech Republic.
  slot:
    index: 4
    item: Carvajal Roca ME
      type: Person
      first name: Maria Eva
      last name: Carvajal Roca
      member of: Hospital La Salud, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.
  slot:
    index: 5
    item: Dupont C
      type: Person
      first name: Christophe
      last name: Dupont
      member of: Ramsay Group, France Et Clinique Marcel Sembat, Paris Descartes University, Boulogne-Billancourt, Paris, France.
  slot:
    index: 6
    item: Huysentruyt K
      type: Person
      first name: Koen
      last name: Huysentruyt
      member of: Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Laarbeeklaan 101, Brussels, Belgium.
  slot:
    index: 7
    item: Kuitunen M
      type: Person
      first name: Mikael
      last name: Kuitunen
      member of: Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  slot:
    index: 8
    item: Meyer R
      type: Person
      first name: Rosan
      last name: Meyer
      member of: Department Paediatrics, Imperial College London, London, SW7 2BX, UK.Department Dietetics, Winchester University, Winchester, SO23 4NR, UK.Department Medicine, KU Leuven, Louvain, Belgium.
  slot:
    index: 9
    item: Pancheva R
      type: Person
      first name: Rouzha
      last name: Pancheva
      member of: Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University of Varna, Varna, Bulgaria.Research Group NutriLect, Department of Neuroscience, Research Institute, Medical University Prof. Dr. Paraskev Stoyanov , Varna, Bulgaria.
  slot:
    index: 10
    item: Koninckx CR
      type: Person
      first name: Carmen Ribes
      last name: Koninckx
      member of: Pediatric Gastroenterology, La Fe University Hospital, Instituto de Investigation Sanitaria La FE Valencia, Valencia, Spain.
  slot:
    index: 11
    item: Salvatore S
      type: Person
      first name: Silvia
      last name: Salvatore
      member of: Department of Paediatrics, University of Insubria, Varese, Italy.
  slot:
    index: 12
    item: Shamir R
      type: Person
      first name: Raanan
      last name: Shamir
      member of: Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center, Lea and Arieh Pickel for Pediatric Research, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  slot:
    index: 13
    item: Staiano A
      type: Person
      first name: Annamaria
      last name: Staiano
      member of: Department of Translational Medical Science, Section of Pediatrics, University Federico II, Naples, Italy.
  slot:
    index: 14
    item: Vandenplas Y
      type: Person
      first name: Yvan
      last name: Vandenplas
      member of: Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Laarbeeklaan 101, Brussels, Belgium.
  slot:
    index: 15
    item: Szajewska H
      type: Person
      first name: Hania
      last name: Szajewska
      member of: Department of Paediatrics, The Medical University of Warsaw, Żwirki I Wigury 63A, 02-091, Warsaw, Poland. szajewska@gmail.com.
created: 2023-11-17T15:28
date last updated: 2025-03-09
issued: 2024-02
dp: 2024 Feb
created: 2023-11-16T23:14
e ISSN: 1432-1076
has issn l: 0340-6199
issue: 2
has NLM journal title abbreviation: Eur J Pediatr
publication name: European journal of pediatrics
language: eng
has national library of medicine journal id: 7603873
derived from: NLM
starting page: 707
ending page: 713
has place of publication: Germany
has primary subject term: D008892
has primary subject term: D016269Q000175
has subject term: D007223
has subject term: D007231
has subject term: D005260
has subject term: D000818
has subject term: D002417
has subject term: D006801
has subject term: D003430
has subject term: D008895
has subject term: D000485
has subject term: D041943
source: Eur J Pediatr. 2024-02;183(2):707-713.
volume: 183

The Remaining Challenge to Diagnose and Manage Cow's Milk Allergy: An Opinion Paper to Daily Clinical Practice.
pmid: 38004156
abstract: Guidelines and recommendations for the diagnosis and management of cow's milk allergy (CMA) in childhood are based on scientific review of the available evidence. While this approach is the most rigorous, guidelines may not fully address all scenarios encountered by clinicians. Many symptoms of CMA overlap with other common childhood illnesses and are subjectively reported by the caregivers of the infant, as is the interpretation of the dietary interventions. Additionally, many healthcare professionals and caregivers do not follow the recommendations to perform an oral food challenge or reintroduction of cow's milk after a diagnostic elimination diet because (1) the infant is doing well and (2) the carer's fear of symptoms relapsing with this procedure. As a result, CMA in infants may be either under-diagnosed leading to reduced quality of life for families or over-diagnosed, resulting in unnecessary long-term elimination diets and increasing the risk for nutritional deficiencies. This paper discusses some of these controversial topics, focusing on misdiagnosis and mismanagement in clinical practice. The lack of objective diagnostic criteria can hamper the diagnosis and management of CMA in daily practice.
has PII: nu15224762
doi: 10.3390/nu15224762
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Vandenplas Y
      type: Person
      first name: Yvan
      last name: Vandenplas
      member of: UZ Brussel, KidZ Health Castle, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.
  slot:
    index: 2
    item: Meyer R
      type: Person
      first name: Rosan
      last name: Meyer
      member of: Department Paediatrics, Imperial College London, London SW7 2BX, UK.Department Dietetics, Winchester University, Winchester SO23 4NR, UK.Department Medicine, KU Leuven, 3001 Leuven, Belgium.
  slot:
    index: 3
    item: Nowak-Wegrzyn A
      type: Person
      first name: Anna
      last name: Nowak-Wegrzyn
      member of: Department of Pediatrics, NYU Grossman School of Medicine, Hassenfeld Children's Hospital, New York, NY 10016, USA.Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, Poland.
  slot:
    index: 4
    item: Salvatore S
      type: Person
      first name: Silvia
      last name: Salvatore
      member of: Department of Pediatrics, Hospital F. Del Ponte , University of Insubria, 21100 Varese, Italy.
  slot:
    index: 5
    item: Venter C
      type: Person
      first name: Carina
      last name: Venter
      member of: Section of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado, Aurora, CO 80045, USA.
  slot:
    index: 6
    item: Vieira MC
      type: Person
      first name: Mario C
      last name: Vieira
      member of: Center for Pediatric Gastroenterology, Hospital Pequeno Príncipe, Curitiba 80250, Brazil.
created: 2023-11-25T12:46
date last updated: 2025-03-09
issued: 2023-11-13
dp: 2023 Nov 13
created: 2023-11-25T01:20
e ISSN: 2072-6643
has issn l: 2072-6643
issue: 22
has NLM journal title abbreviation: Nutrients
publication name: Nutrients
language: eng
has national library of medicine journal id: 101521595
derived from: NLM
has place of publication: Switzerland
has primary subject term: D016269Q000175Q000628
has primary subject term: D044342
has subject term: D007223
has subject term: D000818
has subject term: D005260
has subject term: D002417
has subject term: D006801
has subject term: D011788
has subject term: D008892Q000009
has subject term: D000485
source: Nutrients. 2023-11-13;15(22):.
volume: 15

Cardiovascular-kidney-metabolic syndrome: A step toward multidisciplinary and inclusive care.
pmid: 38056429
abstract: In a recent Presidential Advisory report, the American Heart Association (AHA) defined cardiovascular-kidney-metabolic (CKM) syndrome as a spectrum of pathology associated with dysfunctional or excess adiposity and leading to adverse cardiovascular outcomes. Implementing the guidelines set forth by the AHA has the potential to improve population-wide CKM health.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S1550-4131(23)00384-4
doi: 10.1016/j.cmet.2023.10.015
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Claudel SE
      type: Person
      first name: Sophie E
      last name: Claudel
      member of: Department of Medicine, Boston Medical Center, Boston, MA, USA.
  slot:
    index: 2
    item: Verma A
      type: Person
      first name: Ashish
      last name: Verma
      member of: Department of Medicine, Section of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: ashverma@bu.edu.
created: 2023-12-7T00:42
date last updated: 2025-03-09
issued: 2023-12-05
dp: 2023 12 05
created: 2023-12-6T18:20
e ISSN: 1932-7420
has issn l: 1550-4131
issue: 12
has NLM journal title abbreviation: Cell Metab
publication name: Cell metabolism
language: eng
has national library of medicine journal id: 101233170
derived from: NLM
starting page: 2104
ending page: 2106
has place of publication: United States
has primary subject term: D024821Q000628
has primary subject term: D002318Q000628
has subject term: D006801
has subject term: D007668
source: Cell Metab. 2023-12-05;35(12):2104-2106.
volume: 35

Integrating osteoimmunology and nanoparticle-based drug delivery systems for enhanced fracture healing.
pmid: 38056586
abstract: Fracture healing is a complex interplay of molecular and cellular mechanisms lasting from days to weeks. The inflammatory phase is the first stage of fracture healing and is critical in setting the stage for successful healing. There has been growing interest in exploring the role of the immune system and novel therapeutic strategies, such as nanoparticle drug delivery systems in enhancing fracture healing. Advancements in nanotechnology have revolutionized drug delivery systems to the extent that they can modulate immune response during fracture healing by leveraging unique physiochemical properties. Therefore, understanding the intricate interactions between nanoparticle-based drug delivery systems and the immune response, specifically macrophages, is essential for therapeutic efficacy. This review provides a comprehensive overview of the relationship between the immune system and nanoparticles during fracture healing. Specifically, we highlight the influence of nanoparticle characteristics, such as size, surface properties, and composition, on macrophage activation, polarization, and subsequent immune responses. IMPACT STATEMENT: This review provides valuable insights into the interplay between fracture healing, the immune system, and nanoparticle-based drug delivery systems. Understanding nanoparticle-macrophage interactions can advance the development of innovative therapeutic approaches to enhance fracture healing, improve patient outcomes, and pave the way for advancements in regenerative medicine.
rights: Copyright © 2023. Published by Elsevier Inc.
has PII: S1549-9634(23)00078-3
doi: 10.1016/j.nano.2023.102727
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Xiao B
      type: Person
      first name: Baixue
      last name: Xiao
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14623, USA; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14623, USA.
  slot:
    index: 2
    item: Adjei-Sowah E
      type: Person
      first name: Emmanuela
      last name: Adjei-Sowah
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14623, USA; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14623, USA.
  slot:
    index: 3
    item: Benoit DSW
      type: Person
      first name: Danielle S W
      last name: Benoit
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, NY 14623, USA; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14623, USA; Department of Chemical Engineering, University of Rochester, Rochester, NY 14623, USA; Materials Science Program, University of Rochester, Rochester, NY 14623, USA; Department of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, USA. Electronic address: dbenoit@uoregon.edu.
created: 2023-12-7T00:42
date last updated: 2025-03-09
issued: 2024-02
dp: 2024 Feb
created: 2023-12-6T19:24
e ISSN: 1549-9642
has issn l: 1549-9634
has NLM journal title abbreviation: Nanomedicine
publication name: Nanomedicine : nanotechnology, biology, and medicine
language: eng
has national library of medicine journal id: 101233142
derived from: NLM
pg: 102727
has place of publication: United States
has primary subject term: D017102
has primary subject term: D053758Q000737
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000090783
has subject term: D016503
has subject term: D008264
source: Nanomedicine. 2024-02;56():102727.
volume: 56

Factors Influencing Sexuality in Late Adolescence: A Qualitative Study on Heterosexual Adolescents' Perspectives.
pmid: 38063600
abstract: (1) Background: Sexuality is influenced by the school, family, and social contexts. All of these play a crucial role in promoting adolescents' sexual health and well-being. However, little is known about the factors that have an impact on sexuality in late adolescence. The aim of this study was to explore and describe the perspectives of late adolescents on the factors that influence their sexual lives. (2) Methods: A qualitative study with a descriptive design was carried out. Thirteen interviews were conducted. Data were audio-recorded, transcribed, and categorized into themes and subthemes. (3) Results: The results of our study offer support for the importance of sexual aspects in the lives of late adolescents who identify as heterosexual. (4) Conclusions: The most influential environments in late adolescent sexuality are the social, family, school, and peer contexts.
has PII: healthcare11233032
doi: 10.3390/healthcare11233032
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Fernández-Medina IM
      type: Person
      first name: Isabel María
      last name: Fernández-Medina
      member of: Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.
  slot:
    index: 2
    item: Ramal-Gea MA
      type: Person
      first name: Miguel Angel
      last name: Ramal-Gea
      member of: Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.
  slot:
    index: 3
    item: Ruíz-Fernández MD
      type: Person
      first name: María Dolores
      last name: Ruíz-Fernández
      member of: Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.Faculty of Health Sciences, Universidad Autónoma de Chile, Temuco 4780000, Chile.
  slot:
    index: 4
    item: Granero-Molina J
      type: Person
      first name: José
      last name: Granero-Molina
      member of: Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.Faculty of Health Sciences, Universidad Autónoma de Chile, Temuco 4780000, Chile.
  slot:
    index: 5
    item: Jiménez-Lasserrotte MDM
      type: Person
      first name: María Del Mar
      last name: Jiménez-Lasserrotte
      member of: Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.
  slot:
    index: 6
    item: Ventura-Miranda MI
      type: Person
      first name: María Isabel
      last name: Ventura-Miranda
      member of: Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.
created: 2023-12-8T12:42
date last updated: 2025-03-09
issued: 2023-11-24
dp: 2023 Nov 24
created: 2023-12-8T10:13
ISSN: 2227-9032
has issn l: 2227-9032
issue: 23
has NLM journal title abbreviation: Healthcare (Basel)
publication name: Healthcare (Basel, Switzerland)
language: eng
has national library of medicine journal id: 101666525
derived from: NLM
has place of publication: Switzerland
source: Healthcare (Basel). 2023-11-24;11(23):.
volume: 11

Effects of live-online, group mindfulness training on opioid use and anxiety during buprenorphine treatment: A comparative effectiveness RCT.
pmid: 38135210
abstract: Office-based opioid treatment with buprenorphine has emerged as a popular evidence-based treatment for opioid use disorder. Unfortunately, psychosocial stress, anxiety, pain, and co-morbid substance use increase patients' risk for relapse. We designed this study to compare the effects of complementing buprenorphine treatment with 24 weeks of a live-online Mindful Recovery Opioid Care Continuum (M-ROCC) group to a time and attention-matched, live-online Recovery Support Group (RSG) active control condition.We plan to enroll a maximum of N = 280 and randomize at least N = 192 patients prescribed buprenorphine through referrals from office-based and telemedicine buprenorphine treatment providers and social media advertisements. Participants will be randomly assigned to M-ROCC or RSG and will be blinded to their treatment condition. The primary outcome for this study will be biochemically confirmed periods of abstinence from illicit opioids, as measured by self-reported use and randomly collected, video-observed oral fluid toxicology testing during the final 12 weeks of study participation. Secondary outcomes include changes in Patient-Reported Outcomes Measurement Information System (PROMIS) anxiety and pain interference scores between baseline and week 24.The trial was funded by the National Institutes of Health, HEAL Initiative through NCCIH (R33AT010125). Data collection is projected to end by September 2023, and we expect publication of results in 2024.If the M-ROCC intervention is found to be effective in this format, it will demonstrate that live-online mindfulness groups can improve outcomes and address common co-morbidities like anxiety and pain during buprenorphine treatment.
rights: Copyright © 2023. Published by Elsevier Inc.
has PII: S1551-7144(23)00340-3
doi: 10.1016/j.cct.2023.107417
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Rosansky JA
      type: Person
      first name: Joseph A
      last name: Rosansky
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America; Harvard Medical School, Department of Psychiatry, 25 Shattuck St., Boston, MA 02115, United States of America.
  slot:
    index: 2
    item: Howard L
      type: Person
      first name: Leah
      last name: Howard
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America.
  slot:
    index: 3
    item: Goodman H
      type: Person
      first name: Hannah
      last name: Goodman
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America.
  slot:
    index: 4
    item: Okst K
      type: Person
      first name: Kayley
      last name: Okst
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America.
  slot:
    index: 5
    item: Fatkin T
      type: Person
      first name: Thomas
      last name: Fatkin
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America.
  slot:
    index: 6
    item: Fredericksen AK
      type: Person
      first name: A Kiera
      last name: Fredericksen
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America.
  slot:
    index: 7
    item: Sokol R
      type: Person
      first name: Randi
      last name: Sokol
      member of: Cambridge Health Alliance, Department of Family Medicine, 1493 Cambridge St., Cambridge, MA 02139, United States of America; Tufts University School of Medicine, Family Medicine Residency Training Program, 136 Harrison Ave., Boston, MA 02111, United States of America.
  slot:
    index: 8
    item: Gardiner P
      type: Person
      first name: Paula
      last name: Gardiner
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America.
  slot:
    index: 9
    item: Parry G
      type: Person
      first name: Gareth
      last name: Parry
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America; Harvard Medical School, Department of Psychiatry, 25 Shattuck St., Boston, MA 02115, United States of America.
  slot:
    index: 10
    item: Cook BL
      type: Person
      first name: Benjamin L
      last name: Cook
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America; Harvard Medical School, Department of Psychiatry, 25 Shattuck St., Boston, MA 02115, United States of America; Health Equity Research Lab, Cambridge Health Alliance, Cambridge, MA 02139, United States of America.
  slot:
    index: 11
    item: Weiss RD
      type: Person
      first name: Roger D
      last name: Weiss
      member of: Harvard Medical School, Department of Psychiatry, 25 Shattuck St., Boston, MA 02115, United States of America; McLean Hospital, 115 Mill St., Belmont, MA 02478, United States of America.
  slot:
    index: 12
    item: Schuman-Olivier ZD
      type: Person
      first name: Zev D
      last name: Schuman-Olivier
      member of: Cambridge Health Alliance, Center for Mindfulness and Compassion, 350 Main Street, Suite 5126, Malden, MA 02148, United States of America; Harvard Medical School, Department of Psychiatry, 25 Shattuck St., Boston, MA 02115, United States of America. Electronic address: zschuman@cha.harvard.edu.
created: 2023-12-23T12:42
date last updated: 2025-03-09
issued: 2024-02
dp: 2024 02
created: 2023-12-22T19:33
e ISSN: 1559-2030
has issn l: 1551-7144
has NLM journal title abbreviation: Contemp Clin Trials
publication name: Contemporary clinical trials
language: eng
has national library of medicine journal id: 101242342
derived from: NLM
pg: 107417
has place of publication: United States
has primary subject term: D002047Q000627
has primary subject term: D064866
has primary subject term: D009293Q000188
has subject term: D006801
has subject term: D000701Q000627
has subject term: D009364
has subject term: D001007
has subject term: D010146
source: Contemp Clin Trials. 2024-02;137():107417.
volume: 137

New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease.
pmid: 38146639
abstract: Mitochondrial dysfunction is an early pathological feature of Alzheimer disease and plays a crucial role in the development and progression of Alzheimer's disease. Strategies to rescue mitochondrial function and cognition remain to be explored. Cyclophilin D (CypD), the peptidylprolyl isomerase F (PPIase), is a key component in opening the mitochondrial membrane permeability transition pore, leading to mitochondrial dysfunction and cell death. Blocking membrane permeability transition pore opening by inhibiting CypD activity is a promising therapeutic approach for Alzheimer's disease. However, there is currently no effective CypD inhibitor for Alzheimer's disease, with previous candidates demonstrating high toxicity, poor ability to cross the blood-brain barrier, compromised biocompatibility and low selectivity. Here, we report a new class of non-toxic and biocompatible CypD inhibitor, ebselen, using a conventional PPIase assay to screen a library of ∼2000 FDA-approved drugs with crystallographic analysis of the CypD-ebselen crystal structure (PDB code: 8EJX). More importantly, we assessed the effects of genetic and pharmacological blockade of CypD on Alzheimer's disease mitochondrial and glycolytic bioenergetics in Alzheimer's disease-derived mitochondrial cybrid cells, an ex vivo human sporadic Alzheimer's disease mitochondrial model, and on synaptic function, inflammatory response and learning and memory in Alzheimer's disease mouse models. Inhibition of CypD by ebselen protects against sporadic Alzheimer's disease- and amyloid-β-induced mitochondrial and glycolytic perturbation, synaptic and cognitive dysfunction, together with suppressing neuroinflammation in the brain of Alzheimer's disease mouse models, which is linked to CypD-related membrane permeability transition pore formation. Thus, CypD inhibitors have the potential to slow the progression of neurodegenerative diseases, including Alzheimer's disease, by boosting mitochondrial bioenergetics and improvin[cell cut: 2034 characters, first 2000 kept]
rights: © The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7497276
doi: 10.1093/brain/awad432
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Samanta S
      type: Person
      first name: Sourav
      last name: Samanta
      member of: Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, NY 10032, USA.
  slot:
    index: 2
    item: Akhter F
      type: Person
      first name: Firoz
      last name: Akhter
      member of: Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, NY 10032, USA.
  slot:
    index: 3
    item: Roy A
      type: Person
      first name: Anuradha
      last name: Roy
      member of: High Throughput Screening Laboratory, Del M. Shankel Structural Biology Center, University of Kansas, Lawrence, KS 66047, USA.
  slot:
    index: 4
    item: Chen D
      type: Person
      first name: Doris
      last name: Chen
      member of: Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  slot:
    index: 5
    item: Turner B
      type: Person
      first name: Benjamin
      last name: Turner
      member of: High Throughput Screening Laboratory, Del M. Shankel Structural Biology Center, University of Kansas, Lawrence, KS 66047, USA.
  slot:
    index: 6
    item: Wang Y
      type: Person
      first name: Yongfu
      last name: Wang
      member of: Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  slot:
    index: 7
    item: Clemente N
      type: Person
      first name: Nicolina
      last name: Clemente
      member of: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, New York, NY 12180-3590, USA.
  slot:
    index: 8
    item: Wang C
      type: Person
      first name: Chunyu
      last name: Wang
      member of: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, New York, NY 12180-3590, USA.
  slot:
    index: 9
    item: Swerdlow RH
      type: Person
      first name: Russell Howard
      last name: Swerdlow
      member of: Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
  slot:
    index: 10
    item: Battaile KP
      type: Person
      first name: Kevin P
      last name: Battaile
      member of: New York Structural Biology Center, NSLS-II, Upton, NY 11973, USA.
  slot:
    index: 11
    item: Lovell S
      type: Person
      first name: Scott
      last name: Lovell
      member of: Protein Structure and X-Ray Crystallography Laboratory, The University of Kansas, Lawrence, KS 66047, USA.
  slot:
    index: 12
    item: Yan SF
      type: Person
      first name: Shi Fang
      last name: Yan
      member of: Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, NY 10032, USA.
  slot:
    index: 13
    item: Yan SS
      type: Person
      first name: Shirley ShiDu
      last name: Yan
      member of: Division of Surgical Science of Department of Surgery, Columbia University in New York, New York, NY 10032, USA.Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032, USA.
created: 2023-12-26T06:41
date last updated: 2025-03-09
issued: 2024-05-03
dp: 2024 May 03
created: 2023-12-26T05:28
e ISSN: 1460-2156
has issn l: 0006-8950
issue: 5
has NLM journal title abbreviation: Brain
publication name: Brain : a journal of neurology
language: eng
has national library of medicine journal id: 0372537
derived from: NLM
starting page: 1710
ending page: 1725
has place of publication: England
has primary subject term: D000544Q000188Q000378
has primary subject term: D000081406Q000378
has primary subject term: D008928Q000187Q000378
has primary subject term: D016566
has primary subject term: D054833
has subject term: D000818
has subject term: D051379
has subject term: D006801
has subject term: D003071Q000187
has subject term: D001393Q000494Q000627
has subject term: D021983Q000378Q000037
has subject term: D008822
has subject term: D008810
has subject term: D008297
has subject term: D004195
has subject term: D004791Q000494Q000627
source: Brain. 2024-05-03;147(5):1710-1725.
volume: 147

Lesion network guided delta frequency neuromodulation improves cognition in patients with psychosis spectrum disorders: A pilot study.
pmid: 38183737
abstract: Transcranial electric stimulation (tES) may improve cognition in psychosis spectrum disorders. However, few studies have used novel tES approaches, such as high definition tES (HD-tES) to target specific brain circuits. Recently, the extrastriate visual cortex (V5/MT) has been causally linked to visual hallucinations through lesion network mapping and this may be a promising approach for improving cognition.We aim to determine if causal lesion network guided HD-tES to V5/MT improves cognitive performance as measured by the Brief Assessment of Cognition in Schizophrenia (BACS).A single-blind pilot study with a within-subjects crossover design was performed to characterize the effect of cathodal HD-transcranial direct current stimulation (tDCS) and 2 Hz HD-transcranial alternating current stimulation (tACS) on cognition. Enrolled patients received 20 mins of HD-tES twice daily for 5 consecutive days applied bilaterally to V5/MT with a washout between conditions. BACS assessments were performed at baseline, day-5, and 1-month.6 participants with psychosis spectrum disorder were enrolled. 6 individuals received cathodal HD-tDCS. 4 individuals received 2 Hz HD-tACS. HD-tACS resulted in significant (p < 0.1 baseline to 1-month improvements for Digit Sequencing, Verbal Fluency, and Tower of London. HD-tDCS did not result in significant improvement on any task.HD-tACS targeting V5/MT may be a promising treatment to improve cognitive abilities in individuals with psychosis. By promoting delta oscillations, tACS may enhance cortico-cortico communications across brain networks to improve verbal working memory, processing speed, and executive function. Large-scale investigations are needed to replicate these results.
rights: Copyright © 2024 Elsevier B.V. All rights reserved.
has PII: S1876-2018(23)00444-6
doi: 10.1016/j.ajp.2023.103887
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Molho W
      type: Person
      first name: Willa
      last name: Molho
      member of: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: wmolho@gmail.com.
  slot:
    index: 2
    item: Raymond N
      type: Person
      first name: Nicolas
      last name: Raymond
      member of: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: njraymon@bidmc.harvard.edu.
  slot:
    index: 3
    item: Reinhart RMG
      type: Person
      first name: Robert M G
      last name: Reinhart
      member of: Department of Psychological and Brain Science, Boston University, Boston, MA, USA.
  slot:
    index: 4
    item: Trotti R
      type: Person
      first name: Rebekah
      last name: Trotti
      member of: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  slot:
    index: 5
    item: Grover S
      type: Person
      first name: Shrey
      last name: Grover
      member of: Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  slot:
    index: 6
    item: Keshavan M
      type: Person
      first name: Matcheri
      last name: Keshavan
      member of: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 7
    item: Lizano P
      type: Person
      first name: Paulo
      last name: Lizano
      member of: Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: plizano@bidmc.harvard.edu.
created: 2024-1-7T06:44
date last updated: 2025-03-09
issued: 2024-02
dp: 2024 Feb
created: 2024-1-6T18:02
e ISSN: 1876-2026
has issn l: 1876-2018
has NLM journal title abbreviation: Asian J Psychiatr
publication name: Asian journal of psychiatry
language: eng
has national library of medicine journal id: 101517820
derived from: NLM
pg: 103887
has place of publication: Netherlands
has primary subject term: D011618Q000150Q000628
has primary subject term: D065908Q000379
has subject term: D006801
has subject term: D003071Q000502
has subject term: D008570Q000502
has subject term: D010865
has subject term: D016037
has subject term: D018592
source: Asian J Psychiatr. 2024-02;92():103887.
volume: 92

Racial and ethnic trends in mental health service utilisation and perceived unmet need in the USA.
pmid: 38242681
abstract: Two decades ago, the Surgeon General issued a report highlighting concerning disparities in mental healthcare among racial and ethnic minority populations. The present study characterised national trends in mental health treatment utilisation by race and ethnicity across a 13-year period.Nationally representative data were drawn from the National Survey on Drug Use and Health from 2008 through 2020 (unweighted n=4 41 993). Trends in mental health treatment utilisation and perceived unmet treatment need among individuals with and without psychiatric illness were stratified by race and ethnicity.Logistic regression analyses revealed most racial/ethnic minority groups were less likely to receive treatment than white individuals, regardless of mental health status. Treatment utilisation increased among those with (annual per cent change (APC)=0.83, 95% CI=0.41 to 1.26) and without psychiatric illness (APC=1.39, 95% CI=0.53 to 2.26). Among individuals with psychiatric illness, treatment use increased among white (APC=0.88, 95% CI=0.51 to 1.24), Hispanic (APC=2.12, 95% CI=0.70 to 3.57) and black adults (APC=1.07, 95% CI=0.11 to 2.04). White (APC=1.88, 95% CI=0.86 to 2.91) and Hispanic (APC=2.45, 95% CI=0.02 to 4.93) individuals without psychiatric illness also saw increased treatment use. Although increases in perceived unmet treatment need were observed for all racial and ethnic groups except blacks and Native Americans with psychiatric illness, rates remained low across all groups.Although national rates of mental health treatment utilisation have risen, this was almost entirely observed among white and Hispanic individuals with and without psychiatric illness, highlighting the limited progress made towards eliminating disparities in care.
rights: © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: jech-2023-220683
doi: 10.1136/jech-2023-220683
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Sheehan A
      type: Person
      first name: Ana
      last name: Sheehan
      member of: Department of Psychological, University of Delaware, Newark, Delaware, USA ansheeha@udel.edu.
  slot:
    index: 2
    item: Walsh R
      type: Person
      first name: Rachel
      last name: Walsh
      member of: Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
  slot:
    index: 3
    item: Liu R
      type: Person
      first name: Richard
      last name: Liu
      member of: Massachusetts General Hospital, Boston, Massachusetts, USA.Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.Stanley Center for Psychiatric Research, Eli and Edythe L. Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
created: 2024-1-20T05:42
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 03 08
created: 2024-1-19T21:23
e ISSN: 1470-2738
has issn l: 0143-005X
issue: 4
has NLM journal title abbreviation: J Epidemiol Community Health
publication name: Journal of epidemiology and community health
language: eng
has national library of medicine journal id: 7909766
derived from: NLM
starting page: 228
ending page: 234
has place of publication: England
has primary subject term: D005006
has primary subject term: D008605
has subject term: D000328
has subject term: D006801
has subject term: D006630
has subject term: D008913
has subject term: D044469
has subject term: D014481Q000453
has subject term: http://id.nlm.nih.gov/mesh/D000095223
has subject term: D001741
has subject term: D044467
source: J Epidemiol Community Health. 2024-03-08;78(4):228-234.
volume: 78

Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate.
pmid: 38211589
abstract: Pioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed and active states. However, cell fate control requires the coordination of both lineage-specific gene activation and repression of alternative-lineage programs, a process that is poorly understood. Here, we demonstrate that the pioneer TF FOXA coordinates with PRDM1 TF to recruit nucleosome remodeling and deacetylation (NuRD) complexes and Polycomb repressive complexes (PRCs), which establish highly occupied, accessible nucleosome conformation with bivalent epigenetic states, thereby preventing precocious and alternative-lineage gene expression during human endoderm differentiation. Similarly, the pioneer TF OCT4 coordinates with PRDM14 to form bivalent enhancers and repress cell differentiation programs in human pluripotent stem cells, suggesting that this may be a common and critical function of pioneer TFs. We propose that pioneer and PRDM TFs coordinate to safeguard cell fate through epigenetic repression mechanisms.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S1097-2765(23)01026-2
doi: 10.1016/j.molcel.2023.12.007
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Matsui S
      type: Person
      first name: Satoshi
      last name: Matsui
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 2
    item: Granitto M
      type: Person
      first name: Marissa
      last name: Granitto
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 3
    item: Buckley M
      type: Person
      first name: Morgan
      last name: Buckley
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 4
    item: Ludwig K
      type: Person
      first name: Katie
      last name: Ludwig
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 5
    item: Koigi S
      type: Person
      first name: Sandra
      last name: Koigi
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 6
    item: Shiley J
      type: Person
      first name: Joseph
      last name: Shiley
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 7
    item: Zacharias WJ
      type: Person
      first name: William J
      last name: Zacharias
      member of: Division of Pulmonary Biology and Pulmonary and Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 8
    item: Mayhew CN
      type: Person
      first name: Christopher N
      last name: Mayhew
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  slot:
    index: 9
    item: Lim HW
      type: Person
      first name: Hee-Woong
      last name: Lim
      member of: Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: heewoong.lim@cchmc.org.
  slot:
    index: 10
    item: Iwafuchi M
      type: Person
      first name: Makiko
      last name: Iwafuchi
      member of: Division of Developmental Biology, Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: makiko.iwafuchi@cchmc.org.
created: 2024-1-12T00:42
date last updated: 2025-03-08
issued: 2024-02-01
dp: 2024 Feb 01
created: 2024-1-11T18:41
e ISSN: 1097-4164
has issn l: 1097-2765
issue: 3
has NLM journal title abbreviation: Mol Cell
publication name: Molecular cell
language: eng
has national library of medicine journal id: 9802571
derived from: NLM
starting page: 476
ending page: 489.e10
has place of publication: United States
has primary subject term: D014157Q000235Q000378
has primary subject term: D009707Q000235
has subject term: D006801
has subject term: D002454Q000235
has subject term: D063146Q000378
has subject term: D044127
source: Mol Cell. 2024-02-01;84(3):476-489.e10.
volume: 84

Teleophthalmology at a primary and tertiary eye care network from India: environmental and economic impact.
pmid: 38253864
abstract: To evaluate the environmental and economic impact of teleophthalmological services provided by a primary (rural) and tertiary (urban) eyecare network in India.This prospective study utilised a random sampling method, and administered an environmental and economic impact assessment questionnaire. The study included 324 (primary: 173; tertiary: 151) patients who received teleconsultations from July to September 2022. The primary network (rural) used a colour-coded triage system (Green: eye conditions managed by teleconsult alone; yellow: semi-urgent referral within 1 week to a month, red: urgent referral within a day to a week). The tertiary network (urban) included new and follow-up patients. The environmental impact was assessed by estimating the potential CO2 emissions saved by avoiding travel for various transport modes. Economic impact measured by the potential cost savings from direct (travel) and indirect (food and wages lost) expenses spent by yellow and red referrals (primary) and the first-visit expenses of follow-up (tertiary) patients.The primary rural network saved 2.89 kg CO2/person and 80 km/person. The tertiary urban network saved 176.6 kg CO2/person and 1666 km/person. The potential cost savings on travel expenses were INR 19,970 (USD 250) for the primary (average: INR 370 (USD 4.6) per patient) and INR 758,870 (USD 9486) for the tertiary network (average: INR 8339 (USD 104) per patient). Indirect cost savings (food and wages) were of INR 29,100 (USD 364) for the primary and INR 347,800 (USD 4347) for the tertiary network.Teleophthalmology offers substantial environmental and economic benefits in rural and urban eyecare systems.
rights: © 2024. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
has PII: 10.1038/s41433-024-02934-4
doi: 10.1038/s41433-024-02934-4
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Rani PK
      type: Person
      first name: Padmaja Kumari
      last name: Rani
      member of: Department of Teleophthalmology, L V Prasad Eye Institute, Hyderabad, Telangana, India. rpk@lvpei.org.Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India. rpk@lvpei.org.University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA. rpk@lvpei.org.
  slot:
    index: 2
    item: Khanna RC
      type: Person
      first name: Rohit C
      last name: Khanna
      member of: University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India.Brien Holden Eye Research Centre, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia.
  slot:
    index: 3
    item: Ravindrane R
      type: Person
      first name: Ramyadevi
      last name: Ravindrane
      member of: St Helens and Knowsley Teaching Hospitals, NHS Trust, Merseyside, UK.
  slot:
    index: 4
    item: Yeleswarapu SC
      type: Person
      first name: Sarath Chandra
      last name: Yeleswarapu
      member of: Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India.
  slot:
    index: 5
    item: Panaganti AK
      type: Person
      first name: Anand Kumar
      last name: Panaganti
      member of: Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India.
  slot:
    index: 6
    item: Thakur VS
      type: Person
      first name: Vishal Singh
      last name: Thakur
      member of: Department of Teleophthalmology, L V Prasad Eye Institute, Hyderabad, Telangana, India.Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
  slot:
    index: 7
    item: Sharadi V
      type: Person
      first name: Viresh
      last name: Sharadi
      member of: Department of Teleophthalmology, L V Prasad Eye Institute, Hyderabad, Telangana, India.Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
  slot:
    index: 8
    item: Iype V
      type: Person
      first name: Varghese
      last name: Iype
      member of: Department of Teleophthalmology, L V Prasad Eye Institute, Hyderabad, Telangana, India.Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
  slot:
    index: 9
    item: Rathi VM
      type: Person
      first name: Varsha M
      last name: Rathi
      member of: Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India.
  slot:
    index: 10
    item: Vaddavalli PK
      type: Person
      first name: Pravin Krishna
      last name: Vaddavalli
      member of: Department of Teleophthalmology, L V Prasad Eye Institute, Hyderabad, Telangana, India.Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, India.
created: 2024-1-23T00:42
date last updated: 2025-03-09
issued: 2024-08
dp: 2024 Aug
created: 2024-1-22T23:52
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 11
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 2203
ending page: 2208
has place of publication: England
has primary subject term: D017216Q000191Q000706
has primary subject term: D009885Q000191Q000379Q000706
has primary subject term: D011320Q000191Q000706
has primary subject term: D063128Q000191Q000706
has primary subject term: D003362Q000706
has primary subject term: D001335Q000032
has subject term: D011446
has subject term: D007194
has subject term: D011897
has subject term: D019037Q000191Q000706
has subject term: D019035Q000191Q000706
has subject term: D002245Q000032
has subject term: D004777
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D002648
has subject term: D000293
has subject term: D055815
has subject term: D000328
has subject term: D008875
has subject term: D000368
source: Eye (Lond). 2024-08;38(11):2203-2208.
volume: 38

Recent Approaches on Molecular Markers, Treatment and Novel Drug Delivery System Used for the Management of Colorectal Cancer: A Comprehensive Review.
pmid: 38275054
abstract: Colorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics. Novel potential agents have increased survival in acute and chronic disease conditions, with a higher risk of side effects and cost. However, metastatic disease has an insignificant long-term diagnosis, and significant challenges remain due to last-stage diagnosis and treatment failure. Early detection, survival, and treatment efficacy are all improved by biomarkers. The advancement of cancer biomarkers' molecular pathology and genomics during the last three decades has improved therapy. Clinically useful prognostic biomarkers assist clinical judgment, for example, by predicting the success of EGFR-inhibiting antibodies in the presence of KRAS gene mutations. Few biomarkers are currently used in clinical settings, so further research is still needed. Nanocarriers, with materials like Carbon nanotubes and gold nanoparticles, provide targeted CRC drug delivery and diagnostics. Light-responsive drugs with gold and silica nanoparticles effectively target and destroy CRC cells. We evaluate the potential use of the long non-coding RNA (non-coding RNA) oncogene plasmacytoma variant translocation 1 (PVT1) as a diagnostic, prognostic, and therapeutic biomarker, along with the latest nanotech breakthroughs in CRC diagnosis and treatment.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-137828
doi: 10.2174/0113892010270975231208113157
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Chauhan S
      type: Person
      first name: Sonia
      last name: Chauhan
      member of: Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, U.P, 201306, India.
  slot:
    index: 2
    item: Sharma S
      type: Person
      first name: Sakshi
      last name: Sharma
      member of: Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, U.P, 201306, India.
created: 2024-1-26T06:43
date last updated: 2025-03-08
issued: 2024
dp: 2024
created: 2024-1-26T04:13
e ISSN: 1873-4316
has issn l: 1389-2010
issue: 15
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
starting page: 1969
ending page: 1985
has place of publication: Netherlands
has primary subject term: D000970Q000494
has primary subject term: D014408Q000032Q000235
has primary subject term: D015179Q000175Q000188Q000235
has primary subject term: D005819Q000187Q000235
has primary subject term: D000090783Q000494
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D011379
has subject term: D002986
source: Curr Pharm Biotechnol. 2024;25(15):1969-1985.
volume: 25

From plan to practice: A qualitative study of public mental health therapists' session-planning practices.
pmid: 38300589
abstract: Therapists must dedicate considerable time to session plan to implement evidence-based practices (EBPs) flexibly and with fidelity. It is unclear whether public mental health settings offer the structural and organizational support for therapists to engage in session planning and, therefore, whether they provide the necessary infrastructure for EBP implementation. In Fall 2022, 18 therapists working in public mental health settings in New York City were recruited through snowball sampling to participate in 90-min semistructured qualitative interviews. Therapists were prompted to review their session-planning practices using a chart-stimulated recall strategy; to describe structural, organizational, and individual barriers and facilitators to session planning; and to generate recommendations to support their session planning. Qualitative data were analyzed using thematic analysis. A diverse group of therapists participated in the study-22% identified as Black; 22% as Asian; and 11% as Hispanic/Latinx. Seventy-eight percent of therapists were social workers; and they had on average 6.18 (SD = 5.70) years of clinical experience. The research team identified four multilevel session-planning barriers and three multilevel session-planning facilitators. Therapists proposed seven multilevel recommendations to support their session planning. Overall, therapists indicated that managing high productivity standards, severe clinical presentations, and clients' social needs often prevent them from having time to plan for sessions. Efforts to implement EBPs in public mental health settings cannot neglect the structural realities faced by agencies, therapists, and clients. Multilevel resources and reforms to support therapists' session planning are necessary. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2024-50448-001
doi: 10.1037/ser0000840
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Last BS
      type: Person
      first name: Briana S
      last name: Last
      member of: Department of Psychology, Stony Brook University.
  slot:
    index: 2
    item: Mirhashem R
      type: Person
      first name: Rebecca
      last name: Mirhashem
      member of: Department of Psychology, Stony Brook University.
  slot:
    index: 3
    item: Yang Y
      type: Person
      first name: Yuanyuan
      last name: Yang
      member of: Department of Psychology, Stony Brook University.
created: 2024-2-1T12:42
date last updated: 2025-03-09
issued: 2024-11
dp: 2024 Nov
created: 2024-2-1T11:35
e ISSN: 1939-148X
has issn l: 1541-1559
issue: 4
has NLM journal title abbreviation: Psychol Serv
publication name: Psychological services
language: eng
has national library of medicine journal id: 101214316
derived from: NLM
starting page: 893
ending page: 907
has place of publication: United States
has primary subject term: D036301
has primary subject term: D055317
has subject term: D006801
has subject term: D000328
has subject term: D009519
has subject term: D005260
has subject term: D008297
has subject term: D008605Q000458Q000592
has subject term: D008875
has subject term: D011613
has subject term: http://id.nlm.nih.gov/mesh/D000082383
has subject term: D001523Q000628
has subject term: D001291
source: Psychol Serv. 2024-11;21(4):893-907.
volume: 21

Lactose Intolerance versus Cow's Milk Allergy in Infants: A Clinical Dilemma.
pmid: 38337698
abstract: Due to its very early introduction, cow's milk is one of the first foods that can cause adverse reactions in human beings. Lactose intolerance (LI) and cow's milk allergy (CMA) are the most common adverse reactions to cow's milk. While LI is due to insufficient small intestinal lactase activity and/or a large quantity of ingested lactose, CMA is an aberrant immune reaction to cow's milk proteins, particularly casein or β-lactoglobulin. However, the clinical manifestations of LI and CMA, particularly their gastrointestinal signs and symptoms, are very similar, which might lead to misdiagnosis or delayed diagnosis as well as nutritional risks due to inappropriate dietary interventions or unnecessary dietary restriction. Formula-fed infants with LI should be treated with formula with reduced or no lactose, while those with CMA should be treated with formula containing extensive hydrolyzed cow's milk protein or amino acids. This review is therefore written to assist clinicians to better understand the pathophysiologies of LI and CMA as well as to recognize the similarities and differences between clinical manifestations of LI and CMA.
has PII: nu16030414
doi: 10.3390/nu16030414
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Darma A
      type: Person
      first name: Andy
      last name: Darma
      member of: Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia.Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.
  slot:
    index: 2
    item: Sumitro KR
      type: Person
      first name: Khadijah Rizky
      last name: Sumitro
      member of: Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya 60286, Indonesia.Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.
  slot:
    index: 3
    item: Jo J
      type: Person
      first name: Juandy
      last name: Jo
      member of: Department of Biology, Faculty of Science and Technology, Universitas Pelita Harapan, Tangerang 15811, Indonesia.Mochtar Riady Institute for Nanotechnology, Tangerang 15811, Indonesia.
  slot:
    index: 4
    item: Sitorus N
      type: Person
      first name: Nova
      last name: Sitorus
      member of: Danone Specialized Nutrition Indonesia, Jakarta 12940, Indonesia.
created: 2024-2-10T10:45
date last updated: 2025-03-09
issued: 2024-01-31
dp: 2024 Jan 31
created: 2024-2-10T01:04
e ISSN: 2072-6643
has issn l: 2072-6643
issue: 3
has NLM journal title abbreviation: Nutrients
publication name: Nutrients
language: eng
has national library of medicine journal id: 101521595
derived from: NLM
has place of publication: Switzerland
has primary subject term: D016269
has primary subject term: D007787Q000150
has subject term: D007223
has subject term: D000818
has subject term: D002417
has subject term: D005260
has subject term: D006801
has subject term: D008892Q000009
has subject term: D002364
has subject term: D000485
has subject term: D011492
has subject term: D008894
source: Nutrients. 2024-01-31;16(3):.
volume: 16

Characterizing coma in large vessel occlusion stroke.
pmid: 38366071
abstract: Coma is an unresponsive state of disordered consciousness characterized by impaired arousal and awareness. The epidemiology and pathophysiology of coma in ischemic stroke has been underexplored. We sought to characterize the incidence and clinical features of coma as a presentation of large vessel occlusion (LVO) stroke.Individuals who presented with LVO were retrospectively identified from July 2018 to December 2020. Coma was defined as an unresponsive state of impaired arousal and awareness, operationalized as a score of 3 on NIHSS item 1a.28/637 (4.4%) patients with LVO stroke were identified as presenting with coma. The median NIHSS was 32 (IQR 29-34) for those with coma versus 11 (5-18) for those without (p < 0.0001). In coma, occlusion locations included basilar (13), vertebral (2), internal carotid (5), and middle cerebral (9) arteries. 8/28 were treated with endovascular thrombectomy (EVT), and 20/28 died during the admission. 65% of patients not treated with EVT had delayed presentations or large established infarcts. In models accounting for pre-stroke mRS, basilar occlusion location, intravenous thrombolysis, and EVT, coma independently increased the odds of transitioning to comfort care during admission (aOR 6.75; 95% CI 2.87,15.84; p < 0.001) and decreased the odds of 90-day mRS 0-2 (aOR 0.12; 95% CI 0.03,0.55; p = 0.007).It is not uncommon for patients with LVO to present with coma, and delayed recognition of LVO can lead to poor outcomes, emphasizing the need for maintaining a high index of suspicion. While more commonly thought to result from posterior LVO, coma in our cohort was similarly likely to result from anterior LVO. Efforts to improve early diagnosis and care of patients with LVO presenting with coma are crucial.
rights: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
has PII: 10.1007/s00415-024-12199-2
doi: 10.1007/s00415-024-12199-2
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Young MJ
      type: Person
      first name: Michael J
      last name: Young
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA. michael.young@mgh.harvard.edu.
  slot:
    index: 2
    item: Awad A
      type: Person
      first name: Amine
      last name: Awad
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.
  slot:
    index: 3
    item: Andreev A
      type: Person
      first name: Alexander
      last name: Andreev
      member of: Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  slot:
    index: 4
    item: Bonkhoff AK
      type: Person
      first name: Anna K
      last name: Bonkhoff
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.
  slot:
    index: 5
    item: Schirmer MD
      type: Person
      first name: Markus D
      last name: Schirmer
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.
  slot:
    index: 6
    item: Dmytriw AA
      type: Person
      first name: Adam A
      last name: Dmytriw
      member of: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
  slot:
    index: 7
    item: Vranic JE
      type: Person
      first name: Justin E
      last name: Vranic
      member of: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
  slot:
    index: 8
    item: Rabinov JD
      type: Person
      first name: James D
      last name: Rabinov
      member of: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
  slot:
    index: 9
    item: Doron O
      type: Person
      first name: Omer
      last name: Doron
      member of: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
  slot:
    index: 10
    item: Stapleton CJ
      type: Person
      first name: Christopher J
      last name: Stapleton
      member of: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
  slot:
    index: 11
    item: Das AS
      type: Person
      first name: Alvin S
      last name: Das
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  slot:
    index: 12
    item: Edlow BL
      type: Person
      first name: Brian L
      last name: Edlow
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.
  slot:
    index: 13
    item: Singhal AB
      type: Person
      first name: Aneesh B
      last name: Singhal
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.
  slot:
    index: 14
    item: Rost NS
      type: Person
      first name: Natalia S
      last name: Rost
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.
  slot:
    index: 15
    item: Patel AB
      type: Person
      first name: Aman B
      last name: Patel
      member of: Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
  slot:
    index: 16
    item: Regenhardt RW
      type: Person
      first name: Robert W
      last name: Regenhardt
      member of: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 101 Merrimac Street, Suite 310, Boston, MA, 02114, USA.Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
created: 2024-2-17T12:44
date last updated: 2025-03-09
issued: 2024-05
dp: 2024 May
created: 2024-2-17T00:02
e ISSN: 1432-1459
has issn l: 0340-5354
issue: 5
has NLM journal title abbreviation: J Neurol
publication name: Journal of neurology
language: eng
has national library of medicine journal id: 0423161
derived from: NLM
starting page: 2658
ending page: 2661
has place of publication: Germany
has primary subject term: D003128Q000209
has primary subject term: D000083242Q000628Q000150
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000368
has subject term: D008875
has subject term: D012189
has subject term: D000369
has subject term: D017131
has subject term: D020521Q000628Q000150Q000209
has subject term: D057510
source: J Neurol. 2024-05;271(5):2658-2661.
volume: 271

Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.
pmid: 38366602
abstract: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity.In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity.The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity.This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity.This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.
rights: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
has PII: S2666-6340(24)00040-0
doi: 10.1016/j.medj.2024.01.010
creator: OrderedList
  length: 21
  slot:
    index: 1
    item: Tessier AJ
      type: Person
      first name: Anne-Julie
      last name: Tessier
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: ajtessier@hsph.harvard.edu.
  slot:
    index: 2
    item: Wang F
      type: Person
      first name: Fenglei
      last name: Wang
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  slot:
    index: 3
    item: Liang L
      type: Person
      first name: Liming
      last name: Liang
      member of: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  slot:
    index: 4
    item: Wittenbecher C
      type: Person
      first name: Clemens
      last name: Wittenbecher
      member of: Chalmers University of Technology, Gothenburg, Sweden.
  slot:
    index: 5
    item: Haslam DE
      type: Person
      first name: Danielle E
      last name: Haslam
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 6
    item: Eliassen AH
      type: Person
      first name: A Heather
      last name: Eliassen
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 7
    item: Tobias DK
      type: Person
      first name: Deirdre K
      last name: Tobias
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 8
    item: Li J
      type: Person
      first name: Jun
      last name: Li
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 9
    item: Zeleznik OA
      type: Person
      first name: Oana A
      last name: Zeleznik
      member of: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 10
    item: Ascherio A
      type: Person
      first name: Alberto
      last name: Ascherio
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 11
    item: Sun Q
      type: Person
      first name: Qi
      last name: Sun
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 12
    item: Stampfer MJ
      type: Person
      first name: Meir J
      last name: Stampfer
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 13
    item: Grodstein F
      type: Person
      first name: Francine
      last name: Grodstein
      member of: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  slot:
    index: 14
    item: Rexrode KM
      type: Person
      first name: Kathryn M
      last name: Rexrode
      member of: Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 15
    item: Manson JE
      type: Person
      first name: JoAnn E
      last name: Manson
      member of: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 16
    item: Balasubramanian R
      type: Person
      first name: Raji
      last name: Balasubramanian
      member of: Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
  slot:
    index: 17
    item: Clish CB
      type: Person
      first name: Clary B
      last name: Clish
      member of: Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  slot:
    index: 18
    item: Martínez-González MA
      type: Person
      first name: Miguel A
      last name: Martínez-González
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
  slot:
    index: 19
    item: Chavarro JE
      type: Person
      first name: Jorge E
      last name: Chavarro
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 20
    item: Hu FB
      type: Person
      first name: Frank B
      last name: Hu
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  slot:
    index: 21
    item: Guasch-Ferré M
      type: Person
      first name: Marta
      last name: Guasch-Ferré
      member of: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Public Health and Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: mguasch@hsph.harvard.edu.
created: 2024-2-17T12:44
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 Mar 08
created: 2024-2-17T01:38
e ISSN: 2666-6340
has issn l: 2666-6340
issue: 3
has NLM journal title abbreviation: Med
publication name: Med (New York, N.Y.)
language: eng
has national library of medicine journal id: 101769215
derived from: NLM
starting page: 224
ending page: 238.e5
has place of publication: United States
has primary subject term: D008136
has primary subject term: http://id.nlm.nih.gov/mesh/D000070497
has subject term: D006801
has subject term: D011446
has subject term: D012307
has subject term: D015331
source: Med. 2024-03-08;5(3):224-238.e5.
volume: 5

The Comparison of Patient Characteristics, Therapy Outcome, and Sexual Functions in Vaginismus Patients Prior to and During the COVID-19 Pandemic.
pmid: 38374859
abstract: Background The objective of this study conducted at one center is to compare the demographic features and female sexual functions of patients treated for vaginismus before the COVID-19 pandemic to those treated for vaginismus during the pandemic. Aim Additionally, the study intends to evaluate the results of vaginismus therapy and assess the post-treatment sexual functioning of women. Methods A retrospective analysis was conducted on the medical records of patients diagnosed with vaginismus who sought treatment between March 2018 and March 2022. The enrolled patients were categorized into two groups: the pre-COVID-19 group and the COVID-19 group. The following data have been collected: age, education level, occupation, and marriage duration. After three months of treatment, the patients were called for a follow-up examination and evaluation of their sexual functions. Outcomes Compared to the pre-COVID-19 group, an increase of 52.51% was observed in the number of patients admitted for treatment in the COVID-19 group. Results The severity of vaginismus in the patients was similar in both groups. There were no statistically significant changes observed in any of the areas of the Female Sexual Function Index (FSFI) scale. Clinical implications According to our findings, there was no significant difference in female sexual functioning between women who had vaginismus treatment during the pandemic and those who underwent pre-pandemic treatment. Strengths and limitations The research sample comprised women who sought medical care at our women's health clinic. Conclusions We believe that vaginismus patients who had previously avoided seeking treatment are now seeking it during the pandemic.
rights: Copyright © 2024, Zulfikaroglu et al.
doi: 10.7759/cureus.52612
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Zulfikaroglu EE
      type: Person
      first name: Ebru E
      last name: Zulfikaroglu
      member of: Obstetrics and Gynecology, Eva Women's Health Clinic, Ankara, TUR.
created: 2024-2-20T11:51
date last updated: 2025-03-09
issued: 2024-01
dp: 2024 Jan
created: 2024-2-20T03:35
ISSN: 2168-8184
has issn l: 2168-8184
issue: 1
has NLM journal title abbreviation: Cureus
publication name: Cureus
language: eng
has national library of medicine journal id: 101596737
derived from: NLM
pg: e52612
has place of publication: United States
source: Cureus. 2024-01;16(1):e52612.
volume: 16

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin.
pmid: 38400013
abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively charged property, heparan sulfate (HS) on the surface of host cells is used by many viruses as cofactor to facilitate viral attachment and initiate cellular entry. Therefore, inhibition of the interaction between viruses and HS could be a promising target to inhibit viral infection. In the current study, the interaction between the receptor-binding domain (RBD) of MERS-CoV and heparin was exploited to assess the inhibitory activity of various sulfated glycans such as glycosaminoglycans, marine-sourced glycans (sulfated fucans, fucosylated chondroitin sulfates, fucoidans, and rhamnan sulfate), pentosan polysulfate, and mucopolysaccharide using Surface Plasmon Resonance. We believe this study provides valuable insights for the development of sulfated glycan-based inhibitors as potential antiviral agents.
has PII: v16020237
doi: 10.3390/v16020237
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Yang J
      type: Person
      first name: Jiyuan
      last name: Yang
      member of: The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 2
    item: Song Y
      type: Person
      first name: Yuefan
      last name: Song
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 3
    item: Jin W
      type: Person
      first name: Weihua
      last name: Jin
      member of: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
  slot:
    index: 4
    item: Xia K
      type: Person
      first name: Ke
      last name: Xia
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 5
    item: Burnett GC
      type: Person
      first name: Grace C
      last name: Burnett
      member of: Department of Cell & Molecular Biology, The University of Mississippi Medical Center, Jackson, MS 39216, USA.
  slot:
    index: 6
    item: Qiao W
      type: Person
      first name: Wanjin
      last name: Qiao
      member of: The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.
  slot:
    index: 7
    item: Bates JT
      type: Person
      first name: John T
      last name: Bates
      member of: Department of Cell & Molecular Biology, The University of Mississippi Medical Center, Jackson, MS 39216, USA.
  slot:
    index: 8
    item: Pomin VH
      type: Person
      first name: Vitor H
      last name: Pomin
      member of: Department of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, The University of Mississippi, Oxford, MS 38677, USA.
  slot:
    index: 9
    item: Wang C
      type: Person
      first name: Chunyu
      last name: Wang
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 10
    item: Qiao M
      type: Person
      first name: Mingqiang
      last name: Qiao
      member of: The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.
  slot:
    index: 11
    item: Linhardt RJ
      type: Person
      first name: Robert J
      last name: Linhardt
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.Departments of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 12
    item: Dordick JS
      type: Person
      first name: Jonathan S
      last name: Dordick
      member of: Departments of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 13
    item: Zhang F
      type: Person
      first name: Fuming
      last name: Zhang
      member of: Departments of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
created: 2024-2-24T11:44
date last updated: 2025-03-09
issued: 2024-02-02
dp: 2024 02 02
created: 2024-2-24T01:22
e ISSN: 1999-4915
has issn l: 1999-4915
issue: 2
has NLM journal title abbreviation: Viruses
publication name: Viruses
language: eng
has national library of medicine journal id: 101509722
derived from: NLM
has place of publication: Switzerland
has primary subject term: D006493Q000494
has primary subject term: D065207Q000378
has subject term: D000818
has subject term: D013431Q000737
has subject term: D006025Q000378
has subject term: D006497Q000378
has subject term: D008322
source: Viruses. 2024-02-02;16(2):.
volume: 16

Assessing the role of dryness and burning sensation in diagnosing laryngopharyngeal reflux.
pmid: 38402357
abstract: Laryngopharyngeal reflux disease (LPRD) is a condition characterized by the regurgitation of stomach and duodenal contents into the laryngopharynx, with variable and non-specific symptoms. Therefore, developing an accurate symptom scale for different regions is essential. Notably, the symptoms of dryness and burning sensation in the laryngopharynx or mouth are prevalent among the Chinese population but are often omitted from conventional symptom assessment scales, such as the Reflux Symptom Index (RSI) and Reflux Symptom Score-12 (RSS-12) scales. To address this gap, our study incorporated the symptoms into the RSI and RSS-12 scales, developing the RSI-10/RSS-13 scales. Afterward, we assessed the role of the new scale's reliability (Cronbach's α and test-retest reliability), construct validity (confirmatory factor analysis and confirmatory factor analysis), and diagnostic efficiency. Our study encompassed 479 participants (average = 39.5 ± 13.4 years, 242 female) and 91 (average = 34.01 ± 13.50 years, 44 female) completed 24 h MII-pH monitoring. The Cronbach's α values of 0.80 and 0.82 for the RSI-10 and RSS-13 scales, respectively. RSI-10 and RSS-13 exhibited strong test-retest reliability (ICCs = 0.82-0.96) and diagnostic efficacy (AUC = 0.84-0.85). Furthermore, the factor analysis identified the RSS-13 and its three sub-scales (ear-nose-throat, digestive tract, respiratory tract) exhibited good to excellent structural validity (χ2/df = 1.95, P < 0.01; CFI = 0.95, RMSEA = 0.06, SRMR = 0.05). The AUC optimal thresholds for the RSI-10 and RSS-13 in the Chinese population were 13 and 36, respectively. Besides, the inclusion of the new item significantly improved the diagnostic efficiency of the RSI scale (P = 0.04), suggesting that RSI-10 holds promise as a more effective screening tool for LPRD, and global validation is needed to demonstrate the impact of this new symptom on the diagnosis of LPRD.
rights: © 2024. The Author(s).
has PII: 10.1038/s41598-024-55420-y
doi: 10.1038/s41598-024-55420-y
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zheng X
      type: Person
      first name: Xiaowei
      last name: Zheng
      member of: Department of Otorhinolaryngology Head and Neck Surgery, Shengli Clinical Medical College of Fujian Medical University, 134 Dong Jie, Gulou District, Fuzhou City, 350001, Fujian Province, China.
  slot:
    index: 2
    item: Chen Z
      type: Person
      first name: Zhiwei
      last name: Chen
      member of: Department of Otorhinolaryngology Head and Neck Surgery, Shengli Clinical Medical College of Fujian Medical University, 134 Dong Jie, Gulou District, Fuzhou City, 350001, Fujian Province, China.
  slot:
    index: 3
    item: Chen T
      type: Person
      first name: Ting
      last name: Chen
      member of: Department of Otorhinolaryngology Head and Neck Surgery, Shengli Clinical Medical College of Fujian Medical University, 134 Dong Jie, Gulou District, Fuzhou City, 350001, Fujian Province, China. iambbp@vip.sina.com.
  slot:
    index: 4
    item: Zhou L
      type: Person
      first name: Liqun
      last name: Zhou
      member of: Department of Otorhinolaryngology Head and Neck Surgery, Shengli Clinical Medical College of Fujian Medical University, 134 Dong Jie, Gulou District, Fuzhou City, 350001, Fujian Province, China.
  slot:
    index: 5
    item: Liu C
      type: Person
      first name: Chaofeng
      last name: Liu
      member of: Department of Otorhinolaryngology Head and Neck Surgery, Shengli Clinical Medical College of Fujian Medical University, 134 Dong Jie, Gulou District, Fuzhou City, 350001, Fujian Province, China.
  slot:
    index: 6
    item: Zheng J
      type: Person
      first name: Jingyi
      last name: Zheng
      member of: Department of Otorhinolaryngology Head and Neck Surgery, Shengli Clinical Medical College of Fujian Medical University, 134 Dong Jie, Gulou District, Fuzhou City, 350001, Fujian Province, China.
  slot:
    index: 7
    item: Hu R
      type: Person
      first name: Renyou
      last name: Hu
      member of: Chongqing Jinshan Science and Technology (Group) Co Ltd, Chongqing, 401120, China.
created: 2024-2-25T00:42
date last updated: 2025-03-09
issued: 2024-02-24
dp: 2024 02 24
created: 2024-2-24T23:28
e ISSN: 2045-2322
has issn l: 2045-2322
issue: 1
has NLM journal title abbreviation: Sci Rep
publication name: Scientific reports
language: eng
has national library of medicine journal id: 101563288
derived from: NLM
pg: 4542
has place of publication: England
has primary subject term: D057045Q000175
has subject term: D006801
has subject term: D005260
has subject term: D015203
has subject term: D007013
has subject term: D012677
source: Sci Rep. 2024-02-24;14(1):4542.
volume: 14

Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs.
pmid: 38423011
abstract: Perineural invasion (PNI) and nerve density within the tumor microenvironment (TME) have long been associated with worse outcomes in head and neck squamous cell carcinoma (HNSCC). This prompted an investigation into how nerves within the tumor microenvironment affect the adaptive immune system and tumor growth.We used RNA sequencing analysis of human tumor tissue from a recent HNSCC clinical trial, proteomics of human nerves from HNSCC patients, and syngeneic orthotopic murine models of HPV-unrelated HNSCC to investigate how sensory nerves modulate the adaptive immune system.Calcitonin gene-related peptide (CGRP) directly inhibited CD8 T cell activity in vitro, and blocking sensory nerve function surgically, pharmacologically, or genetically increased CD8 and CD4 T cell activity in vivo.Our data support sensory nerves playing a role in accelerating tumor growth by directly acting on the adaptive immune system to decrease Th1 CD4 T cells and activated CD8 T cells in the TME. These data support further investigation into the role of sensory nerves in the TME of HNSCC and points toward the possible treatment efficacy of blocking sensory nerve function or specifically inhibiting CGRP release or activity within the TME to improve outcomes.1R01DE028282-01, 1R01DE028529-01, 1P50CA261605-01 (to S.D.K.), 1R01CA284651-01 (to S.D.K.), and F31 DE029997 (to L.B.D.).
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S2666-6340(24)00074-6
doi: 10.1016/j.medj.2024.02.002
creator: OrderedList
  length: 27
  slot:
    index: 1
    item: Darragh LB
      type: Person
      first name: Laurel B
      last name: Darragh
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA; Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 2
    item: Nguyen A
      type: Person
      first name: Alexander
      last name: Nguyen
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 3
    item: Pham TT
      type: Person
      first name: Tiffany T
      last name: Pham
      member of: Department of Otolaryngology - Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 4
    item: Idlett-Ali S
      type: Person
      first name: Shaquia
      last name: Idlett-Ali
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 5
    item: Knitz MW
      type: Person
      first name: Michael W
      last name: Knitz
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 6
    item: Gadwa J
      type: Person
      first name: Jacob
      last name: Gadwa
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 7
    item: Bukkapatnam S
      type: Person
      first name: Sanjana
      last name: Bukkapatnam
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 8
    item: Corbo S
      type: Person
      first name: Sophia
      last name: Corbo
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 9
    item: Olimpo NA
      type: Person
      first name: Nicholas A
      last name: Olimpo
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 10
    item: Nguyen D
      type: Person
      first name: Diemmy
      last name: Nguyen
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 11
    item: Van Court B
      type: Person
      first name: Benjamin
      last name: Van Court
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 12
    item: Neupert B
      type: Person
      first name: Brooke
      last name: Neupert
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 13
    item: Yu J
      type: Person
      first name: Justin
      last name: Yu
      member of: Department of Otolaryngology - Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 14
    item: Ross RB
      type: Person
      first name: Richard B
      last name: Ross
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 15
    item: Corbisiero M
      type: Person
      first name: Michaele
      last name: Corbisiero
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 16
    item: Abdelazeem KNM
      type: Person
      first name: Khalid N M
      last name: Abdelazeem
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA; Radiation Biology Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
  slot:
    index: 17
    item: Maroney SP
      type: Person
      first name: Sean P
      last name: Maroney
      member of: Department of Biochemistry and Molecular Genetics, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 18
    item: Galindo DC
      type: Person
      first name: David C
      last name: Galindo
      member of: Department of Biochemistry and Molecular Genetics, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 19
    item: Mukdad L
      type: Person
      first name: Laith
      last name: Mukdad
      member of: Department of Head & Neck Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
  slot:
    index: 20
    item: Saviola A
      type: Person
      first name: Anthony
      last name: Saviola
      member of: Department of Biochemistry and Molecular Genetics, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 21
    item: Joshi M
      type: Person
      first name: Molishree
      last name: Joshi
      member of: Department of Pharmacology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 22
    item: White R
      type: Person
      first name: Ruth
      last name: White
      member of: Department of Medicine, Columbia University, New York, NY, USA.
  slot:
    index: 23
    item: Alhiyari Y
      type: Person
      first name: Yazeed
      last name: Alhiyari
      member of: Department of Head & Neck Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
  slot:
    index: 24
    item: Samedi V
      type: Person
      first name: Von
      last name: Samedi
      member of: Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 25
    item: Van Bokhoven A
      type: Person
      first name: Adrie
      last name: Van Bokhoven
      member of: Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 26
    item: St John M
      type: Person
      first name: Maie
      last name: St John
      member of: Department of Head & Neck Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
  slot:
    index: 27
    item: Karam SD
      type: Person
      first name: Sana D
      last name: Karam
      member of: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA; Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. Electronic address: sana.karam@cuanschutz.edu.
created: 2024-3-1T01:22
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 Mar 08
created: 2024-2-29T18:41
e ISSN: 2666-6340
has issn l: 2666-6340
issue: 3
has NLM journal title abbreviation: Med
publication name: Med (New York, N.Y.)
language: eng
has national library of medicine journal id: 101769215
derived from: NLM
starting page: 254
ending page: 270.e8
has place of publication: United States
has primary subject term: D015740Q000378
has primary subject term: D006258Q000378Q000473
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D015496
has subject term: D018414
has subject term: http://id.nlm.nih.gov/mesh/D000077195
has subject term: D059016
source: Med. 2024-03-08;5(3):254-270.e8.
volume: 5

New thymol-derived triazole exhibits promising activity against Trichophyton rubrum.
pmid: 38453819
abstract: Fungal infections have emerged worldwide, and azole antifungals are widely used to control these infections. However, the emergence of antifungal resistance has been compromising the effectiveness of these drugs. Therefore, the objective of this study was to evaluate the antifungal and cytotoxic activities of the nine new 1,2,3 triazole compounds derived from thymol that were synthesized through Click chemistry. The binding mode prediction was carried out by docking studies using the crystallographic structure of Lanosterol 14α-demethylase G73E mutant from Saccharomyces cerevisiae. The new compounds showed potent antifungal activity against Trichophyton rubrum but did not show relevant action against Aspergillus fumigatus and Candida albicans. For T. rubrum, molecules nº 5 and 8 showed promising results, emphasizing nº 8, whose fungicidal and fungistatic effects were similar to fluconazole. In addition, molecule nº 8 showed low toxicity for keratinocytes and fibroblasts, concluding that this compound demonstrates promising characteristics for developing a new drug for dermatophytosis caused by T. rubrum, or serves as a structural basis for further research.
rights: © 2024. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.
has PII: 10.1007/s42770-024-01295-0
doi: 10.1007/s42770-024-01295-0
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: de Sousa Cutrim TA
      type: Person
      first name: Thiago Antonio
      last name: de Sousa Cutrim
      member of: Pharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil.
  slot:
    index: 2
    item: Eloy MA
      type: Person
      first name: Mariana Alves
      last name: Eloy
      member of: Agrochemical Graduate Program, Federal University of Espírito Santo, Alegre, Espirito Santo, 29500-000, Brazil.
  slot:
    index: 3
    item: Barcelos FF
      type: Person
      first name: Fernando Fontes
      last name: Barcelos
      member of: Plant Biotechnology Graduate Program, Universidade Vila Velha, Vila Velha, Espírito Santo, 29102-770, Brazil.
  slot:
    index: 4
    item: Meireles LM
      type: Person
      first name: Leandra Martins
      last name: Meireles
      member of: Pharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil.
  slot:
    index: 5
    item: de Freitas Ferreira LC
      type: Person
      first name: Lara Chaves
      last name: de Freitas Ferreira
      member of: Agrochemical Graduate Program, Federal University of Espírito Santo, Alegre, Espirito Santo, 29500-000, Brazil.
  slot:
    index: 6
    item: Reis TA
      type: Person
      first name: Tatiana Alves
      last name: Reis
      member of: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  slot:
    index: 7
    item: Gonçalves SS
      type: Person
      first name: Sarah Santos
      last name: Gonçalves
      member of: Center for Research in Medical Mycology, Department of Pathology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
  slot:
    index: 8
    item: Lacerda V
      type: Person
      first name: Valdemar
      last name: Lacerda
      member of: Chemistry Graduate Program, Universidade Federal Do Espírito Santo, Vitória, Espírito Santo, Brazil.
  slot:
    index: 9
    item: Fronza M
      type: Person
      first name: Marcio
      last name: Fronza
      member of: Pharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil.
  slot:
    index: 10
    item: Morais PAB
      type: Person
      first name: Pedro Alves Bezerra
      last name: Morais
      member of: Agrochemical Graduate Program, Federal University of Espírito Santo, Alegre, Espirito Santo, 29500-000, Brazil. pedro.morais@ufes.br.
  slot:
    index: 11
    item: Scherer R
      type: Person
      first name: Rodrigo
      last name: Scherer
      member of: Pharmaceutical Sciences Graduate Program, Universidade Vila Velha, Comissário José Dantas de Melo St., 21, Boa Vista, Vila Velha, Espírito Santo, 29102-770, Brazil. rodrigo.scherer@uvv.br.
created: 2024-3-8T00:43
date last updated: 2025-03-09
issued: 2024-06
dp: 2024 Jun
created: 2024-3-7T23:29
e ISSN: 1678-4405
has issn l: 1517-8382
issue: 2
has NLM journal title abbreviation: Braz J Microbiol
publication name: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
language: eng
has national library of medicine journal id: 101095924
derived from: NLM
starting page: 1287
ending page: 1295
has place of publication: Brazil
has primary subject term: D000935Q000494Q000737
has primary subject term: D014230Q000494Q000737
has primary subject term: D008826
has primary subject term: D013943Q000494Q000737
has primary subject term: D062105
has primary subject term: D003883Q000187Q000235
has subject term: D006801
has subject term: D002176Q000187Q000235
has subject term: D001232Q000187Q000235
has subject term: D012441Q000187Q000235
has subject term: D015603Q000187
has subject term: D014249Q000187Q000235
source: Braz J Microbiol. 2024-06;55(2):1287-1295.
volume: 55

The use of serum methotrexate level as an assessment of biochemical drug adherence in psoriasis.
pmid: 38454565
has PII: 7624237
doi: 10.1093/bjd/ljae096
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ra AG
      type: Person
      first name: Amelle G
      last name: Ra
      member of: Dermatology Centre, Northern Care Alliance NHS Foundation Trust, Manchester, UK.NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  slot:
    index: 2
    item: Littlewood Z
      type: Person
      first name: Zoe
      last name: Littlewood
      member of: Dermatology Centre, Northern Care Alliance NHS Foundation Trust, Manchester, UK.
  slot:
    index: 3
    item: Barton A
      type: Person
      first name: Anne
      last name: Barton
      member of: NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
  slot:
    index: 4
    item: Keevil B
      type: Person
      first name: Brian
      last name: Keevil
      member of: Clinical Biochemistry, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  slot:
    index: 5
    item: McTaggart M
      type: Person
      first name: Malcolm
      last name: McTaggart
      member of: Clinical Biochemistry, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  slot:
    index: 6
    item: Warren RB
      type: Person
      first name: Richard B
      last name: Warren
      member of: Dermatology Centre, Northern Care Alliance NHS Foundation Trust, Manchester, UK.NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
  slot:
    index: 7
    item: Bluett J
      type: Person
      first name: James
      last name: Bluett
      member of: NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
created: 2024-3-8T06:42
date last updated: 2025-03-09
issued: 2024-05-17
dp: 2024 05 17
created: 2024-3-8T01:13
e ISSN: 1365-2133
has issn l: 0007-0963
issue: 6
has NLM journal title abbreviation: Br J Dermatol
publication name: The British journal of dermatology
language: eng
has national library of medicine journal id: 0004041
derived from: NLM
starting page: 927
ending page: 929
has place of publication: England
has primary subject term: D011565Q000188Q000097
has primary subject term: D008727Q000097Q000627
has primary subject term: D003879Q000627Q000008
has primary subject term: http://id.nlm.nih.gov/mesh/D000099059
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D008875
has subject term: D000328
has subject term: D000368
source: Br J Dermatol. 2024-05-17;190(6):927-929.
volume: 190

Long non-coding RNA lung cancer-associated transcript-1 promotes glioblastoma progression by enhancing Hypoxia-inducible factor 1 alpha activity.
pmid: 38456228
abstract: Hypoxia is associated with poor prognosis in many cancers including glioblastoma (GBM). Glioma stem-like cells (GSCs) often reside in hypoxic regions and serve as reservoirs for disease progression. Long non-coding RNAs (lncRNAs) have been implicated in GBM. However, the lncRNAs that modulate GSC adaptations to hypoxia are poorly understood. Identification of these lncRNAs may provide new therapeutic strategies to target GSCs under hypoxia.lncRNAs induced by hypoxia in GSCs were identified by RNA-seq. Lung cancer-associated transcript-1 (LUCAT1) expression was assessed by qPCR, RNA-seq, Northern blot, single molecule FISH in GSCs, and interrogated in IvyGAP, The Cancer Genome Atlas, and CGGA databases. LUCAT1 was depleted by shRNA, CRISPR/Cas9, and CRISPR/Cas13d. RNA-seq, Western blot, immunohistochemistry, co-IP, ChIP, ChIP-seq, RNA immunoprecipitation, and proximity ligation assay were performed to investigate mechanisms of action of LUCAT1. GSC viability, limiting dilution assay, and tumorigenic potential in orthotopic GBM xenograft models were performed to assess the functional consequences of depleting LUCAT1.A new isoform of Lucat1 is induced by Hypoxia inducible factor 1 alpha (HIF1α) and Nuclear factor erythroid 2-related factor 2 (NRF2) in GSCs under hypoxia. LUCAT1 is highly expressed in hypoxic regions in GBM. Mechanistically, LUCAT1 formed a complex with HIF1α and its co-activator CBP to regulate HIF1α target gene expression and GSC adaptation to hypoxia. Depletion of LUCAT1 impaired GSC self-renewal. Silencing LUCAT1 decreased tumor growth and prolonged mouse survival in GBM xenograft models.A HIF1α-LUCAT1 axis forms a positive feedback loop to amplify HIF1α signaling in GSCs under hypoxia. LUCAT1 promotes GSC self-renewal and GBM tumor growth. LUCAT1 is a potential therapeutic target in GBM.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7624290
doi: 10.1093/neuonc/noae036
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Huang H
      type: Person
      first name: Haidong
      last name: Huang
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 2
    item: Shah H
      type: Person
      first name: Hariti
      last name: Shah
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 3
    item: Hao J
      type: Person
      first name: Jing
      last name: Hao
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 4
    item: Lin J
      type: Person
      first name: Jianhong
      last name: Lin
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 5
    item: Prayson RA
      type: Person
      first name: Richard A
      last name: Prayson
      member of: Department of Anatomic Pathology, The Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 6
    item: Xie L
      type: Person
      first name: Liangqi
      last name: Xie
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 7
    item: Bao S
      type: Person
      first name: Shideng
      last name: Bao
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 8
    item: Chakraborty AA
      type: Person
      first name: Abhishek A
      last name: Chakraborty
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 9
    item: Jankowsky E
      type: Person
      first name: Eckhard
      last name: Jankowsky
      member of: Center for RNA Science and Therapeutics and Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  slot:
    index: 10
    item: Zhao J
      type: Person
      first name: Jianjun
      last name: Zhao
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  slot:
    index: 11
    item: Yu JS
      type: Person
      first name: Jennifer S
      last name: Yu
      member of: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.Center for RNA Science and Therapeutics and Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
created: 2024-3-8T06:43
date last updated: 2025-03-09
issued: 2024-08-05
dp: 2024 08 05
created: 2024-3-8T04:23
e ISSN: 1523-5866
has issn l: 1522-8517
issue: 8
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
starting page: 1388
ending page: 1401
has place of publication: England
has primary subject term: D062085Q000235
has primary subject term: D005909Q000378Q000473Q000235
has primary subject term: D051795Q000378Q000235
has primary subject term: D001932Q000378Q000473Q000235
has primary subject term: D015972
has subject term: D006801
has subject term: D000818
has subject term: D051379
has subject term: D014411Q000378Q000473
has subject term: D018450
has subject term: D023041
has subject term: D049109
has subject term: D014407
has subject term: D008819
has subject term: D045744
has subject term: D014408Q000378Q000235
has subject term: D011379
has subject term: D017209
source: Neuro Oncol. 2024-08-05;26(8):1388-1401.
volume: 26

Exploring the antimicrobial and cytotoxic potential of novel chloroquine analogues.
pmid: 38456272
abstract: Aim: To synthesize novel chloroquine analogues and evaluate them for antimicrobial and cytotoxic potential. Methods: Novel analogues were synthesized from chloroquine by nucleophilic substitution reaction at the 4-amino position. Results: Analogue CS1 showed maximum antimicrobial potential (30.3 ± 0.15 mm zone) against Pseudomonas aeruginosa and produced a 19.2 ± 0.21 mm zone against Candida albicans, while CS0 produced no zone at the same concentration. Analogue CS9 has excellent cytotoxic potential (HeLa cell line), showing 100% inhibition (IC50 = 8.9 ± 1.2 μg/ml), compared with CS0 (61.9% inhibition at 30 μg/ml). Conclusion: These synthesized chloroquine analogues have excellent activity against different microbial strains and cervical cancer cell lines (HeLa) compared with their parent molecule.
doi: 10.4155/fmc-2023-0343
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Islam S
      type: Person
      first name: Shamsul
      last name: Islam
      member of: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
  slot:
    index: 2
    item: Shahzad SA
      type: Person
      first name: Sohail A
      last name: Shahzad
      member of: Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
  slot:
    index: 3
    item: Ismail T
      type: Person
      first name: Tariq
      last name: Ismail
      member of: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
  slot:
    index: 4
    item: Sherani UA
      type: Person
      first name: Usman As
      last name: Sherani
      member of: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
  slot:
    index: 5
    item: Khan KM
      type: Person
      first name: Kashif M
      last name: Khan
      member of: Institute of Pharmaceutical Sciences, University of Veterinary & Animal Sciences, Lahore, 54000, Pakistan.
  slot:
    index: 6
    item: Fatima N
      type: Person
      first name: Nighat
      last name: Fatima
      member of: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
  slot:
    index: 7
    item: Khan SA
      type: Person
      first name: Shujaat A
      last name: Khan
      member of: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
  slot:
    index: 8
    item: Mannan A
      type: Person
      first name: Abdul
      last name: Mannan
      member of: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
created: 2024-3-8T06:42
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-3-8T05:27
e ISSN: 1756-8927
has issn l: 1756-8919
issue: 8
has NLM journal title abbreviation: Future Med Chem
publication name: Future medicinal chemistry
language: eng
has national library of medicine journal id: 101511162
rights holder: [Box: see text].
derived from: NLM
starting page: 737
ending page: 749
has place of publication: England
has primary subject term: D002176Q000187
has primary subject term: D002738Q000494Q000737
has primary subject term: D011550Q000187
has primary subject term: D008826
has primary subject term: D000970Q000494Q000737Q000138
has subject term: D006801
has subject term: D006367
has subject term: D000900Q000494Q000737Q000138
has subject term: D013329
has subject term: D000935Q000494Q000737Q000138
has subject term: D015394
has subject term: D004354
has subject term: D049109Q000187
has subject term: D000890Q000494Q000737Q000138
source: Future Med Chem. 2024;16(8):737-749.
volume: 16

Diagnostic predictability of serum miR-4793-3p and miR-1180-3p expression in community-acquired pneumonia.
pmid: 38456294
abstract: Background: Early identification of community-acquired pneumonia (CAP) is crucial to prevent severe progression. Methods: The authors enrolled 150 hospitalized CAP patients and collected clinicopathologic features and blood indicators. Plasma miRNA profiling was conducted using microarray detection, and selected miRNAs were tested with reverse transcription quantitative PCR. Predictive models were built using least shrinkage and selection operator regression. Results: Least shrinkage and selection operator regression identified two miRNAs (miR-4793-3p and miR-1180-3p) that distinguished mild from severe CAP patients (area under the curve = 0.948). The miRNA model outperformed D-dimer, platelet and procalcitonin (max area under the curve = 0.729). Conclusion: Increased levels of miR-4793-3p and miR-1180-3p may indicate severe pneumonia development. Plasma miRNA profiling enables early prediction of severe CAP, aiding therapeutic decisions.
doi: 10.2217/bmm-2023-0463
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Chai R
      type: Person
      first name: Rong
      last name: Chai
      member of: Department of Respiratory & Critical Care Medicine, Changhai Hospital, Navy Military Medical University, No. 168 Changhai RD, Yangpu District, Shanghai, P.R. China.
  slot:
    index: 2
    item: Zhou C
      type: Person
      first name: Cihang
      last name: Zhou
      member of: Department of General Practice Teaching & Research Office, Changhai Hospital, Navy Military Medical University, No. 168 Changhai RD, Yangpu District, Shanghai, P.R. China.
  slot:
    index: 3
    item: Hu Z
      type: Person
      first name: Zhenli
      last name: Hu
      member of: Department of Respiratory & Critical Care Medicine, Changhai Hospital, Navy Military Medical University, No. 168 Changhai RD, Yangpu District, Shanghai, P.R. China.
  slot:
    index: 4
    item: Hu J
      type: Person
      first name: Jingjing
      last name: Hu
      member of: Department of Clinical Laboratory, Changhai Hospital, Navy Military Medical University, No. 168 Changhai RD, Yangpu District, Shanghai, P.R. China.
created: 2024-3-8T06:43
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-3-8T05:28
e ISSN: 1752-0371
has issn l: 1752-0363
issue: 6
has NLM journal title abbreviation: Biomark Med
publication name: Biomarkers in medicine
language: eng
has national library of medicine journal id: 101312535
derived from: NLM
starting page: 231
ending page: 241
has place of publication: England
has primary subject term: D017714Q000097Q000175Q000235
has primary subject term: D035683Q000097Q000235
has primary subject term: D011014Q000097Q000175Q000235
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D008875
has subject term: D000368
has subject term: D015415Q000097
has subject term: D012372
source: Biomark Med. 2024;18(6):231-241.
volume: 18

IDH-mutant astrocytoma arising from a demyelinating plaque in a child with X-linked adrenoleukodystrophy.
pmid: 38456320
has PII: 7624297
doi: 10.1093/jnen/nlae021
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Kalter JA
      type: Person
      first name: Joshua A
      last name: Kalter
      member of: Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 2
    item: Yang RA
      type: Person
      first name: Ronald A
      last name: Yang
      member of: Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 3
    item: Toland A
      type: Person
      first name: Angus
      last name: Toland
      member of: Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 4
    item: Milla S
      type: Person
      first name: Sarah
      last name: Milla
      member of: Department of Radiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 5
    item: Lund TC
      type: Person
      first name: Troy C
      last name: Lund
      member of: Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.
  slot:
    index: 6
    item: Hankinson T
      type: Person
      first name: Todd
      last name: Hankinson
      member of: Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA.Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 7
    item: Dahl NA
      type: Person
      first name: Nathan A
      last name: Dahl
      member of: Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
created: 2024-3-8T06:43
date last updated: 2025-03-09
issued: 2024-03-20
dp: 2024 03 20
created: 2024-3-8T05:30
e ISSN: 1554-6578
has issn l: 0022-3069
issue: 4
has NLM journal title abbreviation: J Neuropathol Exp Neurol
publication name: Journal of neuropathology and experimental neurology
language: eng
has national library of medicine journal id: 2985192R
derived from: NLM
starting page: 289
ending page: 292
has place of publication: England
has primary subject term: D000326Q000235
has primary subject term: D001254Q000235
has primary subject term: D001932Q000000981Q000235
has subject term: D002648
has subject term: D006801
has subject term: D007521Q000235
has subject term: D009154Q000235
source: J Neuropathol Exp Neurol. 2024-03-20;83(4):289-292.
volume: 83

Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus.
pmid: 38456386
abstract: Hereditary angioedema (HAE) is a rare inherited disorder causing recurrent episodes of swelling that can be potentially life threatening. Treatment of HAE can be divided into on-demand treatment for swelling, and prophylaxis. The last UK consensus on HAE was in 2014 and since then, new medications for prophylaxis have been developed, with more drugs in the pipeline. International guidelines currently recommend the use of long-term prophylaxis (LTP) as the only way of achieving disease control and normalizing patient lives. Modern prophylactic medications are available in the UK, although access is restricted primarily by HAE attack frequency. To establish an updated view of UK clinicians and patients, a Delphi process was used to develop statements regarding LTP as well as other aspects of HAE management. There was consensus that UK access criteria for modern LTP agents based on numerical frequency of attacks alone are too simplistic and potentially disadvantage a cohort of patients who may benefit from LTP. Additionally, there was agreement that patients should be seen in expert centres, remote monitoring of patients is popular post-pandemic, and that the use of patient-reported outcome measures has the potential to improve patient care. Psychological health is an area in which patients may benefit, and recognition of this is important for future research and development.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7624313
doi: 10.1093/cei/uxae020
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Yong PFK
      type: Person
      first name: Patrick F K
      last name: Yong
      member of: Department of Immunology, Frimley Health NHS Foundation Trust, Frimley, UK.
  slot:
    index: 2
    item: Annals R
      type: Person
      first name: Rachel
      last name: Annals
      member of: Hereditary Angioedema UK, Bridgwater, UK.
  slot:
    index: 3
    item: Diwakar L
      type: Person
      first name: Lavanya
      last name: Diwakar
      member of: Department of Immunology, University Hospital of North Midlands NHS Trust, Stoke-on-Trent, UK.
  slot:
    index: 4
    item: Elkhalifa S
      type: Person
      first name: Shuayb
      last name: Elkhalifa
      member of: Department of Allergy and Immunology, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
  slot:
    index: 5
    item: Gompels M
      type: Person
      first name: Mark
      last name: Gompels
      member of: Department of Immunology, North Bristol NHS Trust, Bristol, UK.
  slot:
    index: 6
    item: Jain R
      type: Person
      first name: Rashmi
      last name: Jain
      member of: Department of Clinical Immunology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  slot:
    index: 7
    item: Karim MY
      type: Person
      first name: Mohammed Yousuf
      last name: Karim
      member of: Hematopathology, Sidra Medicine, Doha, Qatar.
  slot:
    index: 8
    item: Khan S
      type: Person
      first name: Sujoy
      last name: Khan
      member of: Department of Immunology and Allergy, Hull University Teaching Hospitals NHS Trust, Hull, UK.
  slot:
    index: 9
    item: Metcalfe A
      type: Person
      first name: Angela
      last name: Metcalfe
      member of: Hereditary Angioedema UK, Bridgwater, UK.
  slot:
    index: 10
    item: Noorani S
      type: Person
      first name: Sadia
      last name: Noorani
      member of: Department of Immunology, Sandwell and West Birmingham NHS Trust, Birmingham, UK.
  slot:
    index: 11
    item: Steele C
      type: Person
      first name: Cathal
      last name: Steele
      member of: Regional Immunology Service, Royal Hospitals Belfast, Belfast, UK.
  slot:
    index: 12
    item: Kiani-Alikhan S
      type: Person
      first name: Sorena
      last name: Kiani-Alikhan
      member of: Department of Immunology, Royal Free London NHS Foundation Trust, London, UK.
  slot:
    index: 13
    item: Garcez T
      type: Person
      first name: Tomaz
      last name: Garcez
      member of: Department of Immunology, Manchester University NHS Foundation Trust, Manchester, UK.
created: 2024-3-8T06:42
date last updated: 2025-03-09
issued: 2024-06-20
dp: 2024 Jun 20
created: 2024-3-8T05:54
e ISSN: 1365-2249
has issn l: 0009-9104
issue: 1
has NLM journal title abbreviation: Clin Exp Immunol
publication name: Clinical and experimental immunology
language: eng
has national library of medicine journal id: 0057202
derived from: NLM
starting page: 109
ending page: 116
has place of publication: England
has primary subject term: D054179Q000517Q000188
has primary subject term: D032921
has primary subject term: D003697
has subject term: D006801
has subject term: D006113
has subject term: D050718Q000627
source: Clin Exp Immunol. 2024-06-20;217(1):109-116.
volume: 217

KRAS Mutation Detection with (2S,4R)-4-[18F]FGln for Noninvasive PDAC Diagnosis.
pmid: 38456403
abstract: Pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis and nonspecific symptoms and progresses rapidly, is the most common pancreatic cancer type. Inhibitors targeting KRAS G12D and G12C mutations have been pivotal in PDAC treatment. Cancer cells with different KRAS mutations exhibit various degrees of glutamine dependency; in particular, cells with KRAS G12D mutations exhibit increased glutamine uptake. (2S,4R)-4-[18F]FGln has recently been developed for clinical cancer diagnosis and tumor cell metabolism analysis. Thus, we verified the heterogeneity of glutamine dependency in PDAC models with different KRAS mutations by a visual and noninvasive method with (2S,4R)-4-[18F]FGln. Two tumor-bearing mouse models (bearing the KRAS G12D or G12C mutation) were injected with (2S,4R)-4-[18F]FGln, and positron emission tomography (PET) imaging features and biodistribution were observed and analyzed. The SUVmax in the regions of interest (ROI) was significantly higher in PANC-1 (G12D) tumors than in MIA PaCa-2 (G12C) tumors. Biodistribution analysis revealed higher tumor accumulation of (2S,4R)-4-[18F]FGln and other metrics, such as T/M and T/B, in the PANC-1 mouse models compared to those in the MIAPaCa-2 mouse models. In conclusion, PDAC cells with the KRAS G12D and G12C mutations exhibit various degrees of (2S,4R)-4-[18F]FGln uptake, indicating that (2S,4R)-4-[18F]FGln might be applied to detect KRAS G12C and G12D mutations and provide treatment guidance.
doi: 10.1021/acs.molpharmaceut.4c00082
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Liu S
      type: Person
      first name: Song
      last name: Liu
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 2
    item: Liu F
      type: Person
      first name: Futao
      last name: Liu
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 3
    item: Hou X
      type: Person
      first name: Xingguo
      last name: Hou
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 4
    item: Zhang Q
      type: Person
      first name: Qian
      last name: Zhang
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 5
    item: Ren Y
      type: Person
      first name: Ya'nan
      last name: Ren
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 6
    item: Zhu H
      type: Person
      first name: Hua
      last name: Zhu
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 7
    item: Yang Z
      type: Person
      first name: Zhi
      last name: Yang
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  slot:
    index: 8
    item: Xu X
      type: Person
      first name: Xiaoxia
      last name: Xu
      member of: State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
created: 2024-3-8T12:43
date last updated: 2025-03-09
issued: 2024-04-01
dp: 2024 Apr 01
created: 2024-3-8T07:59
e ISSN: 1543-8392
has issn l: 1543-8384
issue: 4
has NLM journal title abbreviation: Mol Pharm
publication name: Molecular pharmaceutics
language: eng
has national library of medicine journal id: 101197791
derived from: NLM
starting page: 2034
ending page: 2042
has place of publication: United States
has primary subject term: D021441Q000000981Q000235
has primary subject term: D010190Q000000981Q000235
has subject term: D000818
has subject term: D051379
has subject term: D005973Q000378Q000494
has subject term: D009154
has subject term: D016283Q000235
has subject term: D014018
has subject term: D005462Q000737Q000494
source: Mol Pharm. 2024-04-01;21(4):2034-2042.
volume: 21

Identification of the YIPF3-YIPF4 heterodimer as a novel Golgiphagy receptor.
pmid: 38456639
abstract: Golgiphagy is a selective form of macroautophagy, characterized by the targeted degradation of Golgi compartments through specific receptors. In two recent studies, the YIPF3-YIPF4 heterodimer has been independently identified as the first Golgiphagy receptor within mammalian cells. This heterodimeric complex exhibits a direct affinity for mammalian Atg8-family proteins (ATG8s), thereby facilitating the expansion of phagophores in proximity to Golgi regions. Notably, the interaction between YIPF3-YIPF4 heterodimers and ATG8s undergoes regulatory modulation through phosphorylation. Furthermore, cells lacking either YIPF3 or YIPF4 display defects in Golgiphagy. To elucidate the physiological relevance of these proteins, the necessity of YIPF3-YIPF4 in orchestrating Golgi proteome remodeling was substantiated through experimentation in an in vitro neuronal differentiation model.Abbreviation: ATG: autophagy related; ATG8s: mammalian Atg8-family proteins; LIR, LC3-interacting region.
doi: 10.1080/15548627.2024.2323297
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Huang Y
      type: Person
      first name: Yuxiang
      last name: Huang
  slot:
    index: 2
    item: Klionsky DJ
      type: Person
      first name: Daniel J
      last name: Klionsky
      member of: Life Sciences Institute and Department of Molecular, Cellular and Development Biology, University of Michigan, Ann Arbor, MI, USA.
created: 2024-3-8T12:43
date last updated: 2025-03-09
issued: 2024-06
dp: 2024 06
created: 2024-3-8T08:33
e ISSN: 1554-8635
has issn l: 1554-8627
issue: 6
has NLM journal title abbreviation: Autophagy
publication name: Autophagy
language: eng
has national library of medicine journal id: 101265188
derived from: NLM
starting page: 1211
ending page: 1212
has place of publication: United States
has primary subject term: D001343Q000502
has primary subject term: D006056Q000378
has subject term: D000818
has subject term: D006801
has subject term: D055503
source: Autophagy. 2024-06;20(6):1211-1212.
volume: 20

Pink1 balances reticulophagy and mitophagy by regulating distinct E3 ubiquitin ligases.
pmid: 38456640
abstract: The selective clearance of unwanted, damaged or dangerous components by macroautophagy/autophagy is critical for maintaining cellular homeostasis in organisms from yeast to humans. In recent years, significant progress has been made in understanding how phagophores selectively sequester specific cargo. Nevertheless, a fundamental question remains: Can distinct selective autophagy programs simultaneously operate within the same cell? A recent study from the Baehrecke lab has unveiled a developmentally programmed Pink1-dependent reticulophagy process in the Drosophila intestine. Furthermore, this study demonstrated that autophagy differentially clears mitochondria and ER in the same cell under the regulation of Pink1 through different E3 ubiquitin ligases, highlighting the need for further exploration in understanding the complexity of autophagic substrate selection and crosstalk between diverse autophagy programs.
doi: 10.1080/15548627.2024.2323294
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Yin Z
      type: Person
      first name: Zhangyuan
      last name: Yin
      member of: Life Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.Broad Institute of MIT and Harvard, Program in Infectious Disease and Microbiome, Cambridge, MA USA.
  slot:
    index: 2
    item: Klionsky DJ
      type: Person
      first name: Daniel J
      last name: Klionsky
      member of: Life Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
created: 2024-3-8T12:43
date last updated: 2025-03-09
issued: 2024-05
dp: 2024 05
created: 2024-3-8T08:33
e ISSN: 1554-8635
has issn l: 1554-8627
issue: 5
has NLM journal title abbreviation: Autophagy
publication name: Autophagy
language: eng
has national library of medicine journal id: 101265188
derived from: NLM
starting page: 983
ending page: 984
has place of publication: United States
has primary subject term: D044767Q000378
has primary subject term: D063306Q000502
has subject term: D000818
has subject term: D006801
has subject term: D029721Q000378Q000235
has subject term: D001343Q000502
has subject term: D017346Q000378
has subject term: D008928Q000378
has subject term: D004331Q000378
source: Autophagy. 2024-05;20(5):983-984.
volume: 20

Assessing the Level of Poverty and Utilization of Government Social Programs Among Tobacco Farmers in Indonesia.
pmid: 38456837
abstract: Studies examining profit suggest that former tobacco farmers do as well or better than current tobacco farmers. Research has yet to examine the relationship among current and former tobacco farmers, poverty, and receipt of government social assistance. This type of research is critical to understanding the direct and indirect subsidization of tobacco growing. This study analyzed tobacco farmers' poverty levels and receipt of government social assistance programs.We designed and conducted an original four-wave economic survey of current and former tobacco farming households in Indonesia between 2016 and 2022. We then used descriptive analysis and probit regression for panel data to estimate the relationship between tobacco farming and poverty status.Tobacco farmers' per capita income and poverty rates vary across years. The poverty rate was significantly higher in the year with a higher-than-normal rainfall as it negatively affected farming outcomes. During this year, the poverty rate among current tobacco farmers was also higher than that of former tobacco farmers. Regression estimates from the panel data confirm the association between tobacco farming and the likelihood of being poor. We also found a high share of current tobacco farmers who receive government social assistance programs, such as cash transfer programs and a universal healthcare program.Our findings show high poverty rates-particularly during bad farming years-and high rates of government social assistance among tobacco farmers. The high rates of government assistance among tobacco farmers living in poverty show that the government is indirectly subsidizing the tobacco industry.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7624464
doi: 10.1093/ntr/ntae050
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Sahadewo GA
      type: Person
      first name: Gumilang Aryo
      last name: Sahadewo
      member of: Departement of Economics, Faculty of Economics and Business, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  slot:
    index: 2
    item: Lencucha R
      type: Person
      first name: Raphael
      last name: Lencucha
      member of: School of Physical and Occupational Therapy, Faculty of Medicine and Health and Sciences, McGill University, Montreal, QC, Canada.
  slot:
    index: 3
    item: Bandara S
      type: Person
      first name: Shashika
      last name: Bandara
      member of: Department of Family Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
  slot:
    index: 4
    item: Drope J
      type: Person
      first name: Jeffrey
      last name: Drope
      member of: Bloomberg School of Public Health, John Hopkins University, Baltimore, MD, USA.
  slot:
    index: 5
    item: Witoelar F
      type: Person
      first name: Firman
      last name: Witoelar
      member of: Crawford School of Public Policy, Australian National University, Canberra, ACT, Australia.
created: 2024-3-8T12:42
date last updated: 2025-03-09
issued: 2024-08-22
dp: 2024 Aug 22
created: 2024-3-8T10:42
e ISSN: 1469-994X
has issn l: 1462-2203
issue: 9
has NLM journal title abbreviation: Nicotine Tob Res
publication name: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
language: eng
has national library of medicine journal id: 9815751
derived from: NLM
starting page: 1132
ending page: 1140
has place of publication: England
has primary subject term: D000067565Q000706
has primary subject term: D011203Q000706
has subject term: D007214Q000453
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000328
has subject term: D006078Q000191Q000706
has subject term: D011632Q000706
has subject term: D007182Q000706
has subject term: D014026
has subject term: D011795
source: Nicotine Tob Res. 2024-08-22;26(9):1132-1140.
volume: 26

Melanotic Neuroectodermal Tumor of Infancy: A Case Image.
pmid: 38456974
abstract: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign neoplasm that can be mistaken for malignancies due to its unfamiliarity among clinicians and aggressive clinical appearance. We herein contributed by reporting an additional case of MNTI characterized by an extensive extraoral protrusion in a 2-month-old infant. The lesion involved the anterior maxilla, cheek, and infraorbital region, resulting the displacement of the nose to the contralateral side, and measuring approximately 10 cm in size. Surgical resection of the lesion was performed. After a 6-month follow-up, the patient has shown no evidence of recurrence. The rapid growth and aggressive behavior of MNTI emphasize the importance of an early diagnosis and prompt intervention in order to achieve favorable outcomes.
rights: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12105-024-01619-4
doi: 10.1007/s12105-024-01619-4
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Monsalve R
      type: Person
      first name: Ricardo
      last name: Monsalve
      member of: Hospital Dr. Domingo Luciani, Caracas, Venezuela.
  slot:
    index: 2
    item: Arias C
      type: Person
      first name: César
      last name: Arias
      member of: Hospital Dr. Domingo Luciani, Caracas, Venezuela.
  slot:
    index: 3
    item: Vélez H
      type: Person
      first name: Henrique
      last name: Vélez
      member of: Hospital Dr. Domingo Luciani, Caracas, Venezuela.
  slot:
    index: 4
    item: Villarroel-Dorrego M
      type: Person
      first name: Mariana
      last name: Villarroel-Dorrego
      member of: Department of Oral Medicine, School of Dentistry, Universidad Central de Venezuela, Caracas, Venezuela.
  slot:
    index: 5
    item: de Arruda JAA
      type: Person
      first name: José Alcides Almeida
      last name: de Arruda
      member of: Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, R. Rodolpho Paulo Rocco, n. 325, 1st floor, Cidade Universitária, Rio de Janeiro, RJ, CEP: 21.941-902, Brazil. alcides_almeida@hotmail.com.
  slot:
    index: 6
    item: de Andrade BAB
      type: Person
      first name: Bruno Augusto Benevenuto
      last name: de Andrade
      member of: Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, R. Rodolpho Paulo Rocco, n. 325, 1st floor, Cidade Universitária, Rio de Janeiro, RJ, CEP: 21.941-902, Brazil.
created: 2024-3-8T12:43
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 Mar 08
created: 2024-3-8T11:07
e ISSN: 1936-0568
has issn l: 1936-055X
issue: 1
has NLM journal title abbreviation: Head Neck Pathol
publication name: Head and neck pathology
language: eng
has national library of medicine journal id: 101304010
derived from: NLM
pg: 15
has place of publication: United States
has primary subject term: D017600Q000175Q000473Q000601
has subject term: D006801
has subject term: D007223
has subject term: D002610Q000473
has subject term: D008437Q000473
source: Head Neck Pathol. 2024-03-08;18(1):15.
volume: 18

Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma.
pmid: 38457034
abstract: Despite the increasing recognition of PD-L1 as predictor of immunotherapeutic response in various malignancies, its role and prognostic significance in thyroid cancer remain underexplored and subject to debate. This study begins to address this gap by comprehensively analyzing PD-L1 expression in papillary thyroid carcinoma (PTC) and investigating its correlation with key clinicopathological variables.We conducted immunohistochemistry (IHC) to assess PD-L1 expression in whole-tissue sections from 121 primary papillary thyroid carcinoma (PTC) cases. We then analyzed the correlations between PD-L1 expression and various clinicopathological variables.PD-L1 expression was detected in 33.1% of papillary thyroid carcinomas (PTCs), predominantly exhibiting weak to moderate intensity. Notably, this study found no significant correlation between PD-L1 expression and various clinicopathological variables. The lack of association with traditional factors such as age, sex, histological subtype, and tumor size suggests the complex and multifaceted nature of PD-L1 regulation in PTC. Multivariate logistic regression analysis identified chronic lymphocytic thyroiditis with oncocytic metaplasia as the sole independent predictor of PD-L1 expression (P = 0.014), underlining the potential influence of the tumor microenvironment on immune checkpoint expression in PTC.Our study underscores the intricate interplay between chronic lymphocytic thyroiditis with oncocytic metaplasia and PD-L1 expression in papillary thyroid carcinoma. The observed link suggests a potential avenue for therapeutic intervention using anti-PD-1/PD-L1 therapies in surgery-refractory PTC. Understanding the dynamics of immune checkpoint regulation in the context of the tumor microenvironment is crucial for devising effective treatment strategies. Future research endeavors should delve deeper into the molecular mechanisms underlying this interaction and explore its implications for patient outcomes. As the field of i[cell cut: 2135 characters, first 2000 kept]
rights: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12105-024-01618-5
doi: 10.1007/s12105-024-01618-5
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Santana VB
      type: Person
      first name: Vitor Barreto
      last name: Santana
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil. vitor_barretoo@hotmail.com.
  slot:
    index: 2
    item: Krüger VM
      type: Person
      first name: Vitória Machado
      last name: Krüger
      member of: Rio Grande Sul State Health Department, Porto Alegre, RS, Brazil.
  slot:
    index: 3
    item: Abrahão MCY
      type: Person
      first name: Maria Cristina Yunes
      last name: Abrahão
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 4
    item: Cantú PLM
      type: Person
      first name: Pietru Lentz Martins
      last name: Cantú
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 5
    item: Brackmann RL
      type: Person
      first name: Rosicler Luzia
      last name: Brackmann
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 6
    item: Pandolfi GM
      type: Person
      first name: Gisele Moroni
      last name: Pandolfi
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 7
    item: Marisco LS
      type: Person
      first name: Liane Scheffler
      last name: Marisco
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 8
    item: Remonatto G
      type: Person
      first name: Gabriela
      last name: Remonatto
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 9
    item: Ferreira LA
      type: Person
      first name: Luciana Adolfo
      last name: Ferreira
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.
  slot:
    index: 10
    item: Graudenz MS
      type: Person
      first name: Marcia Silveira
      last name: Graudenz
      member of: Department of Pathology, Hospital de Clínicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, 2350, 90035-903, Rio Grande do Sul, Brazil.Laboratory of Pathology, Genetics and Molecular Biology, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
created: 2024-3-8T12:42
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 Mar 08
created: 2024-3-8T11:09
e ISSN: 1936-0568
has issn l: 1936-055X
issue: 1
has NLM journal title abbreviation: Head Neck Pathol
publication name: Head and neck pathology
language: eng
has national library of medicine journal id: 101304010
derived from: NLM
pg: 14
has place of publication: United States
has primary subject term: D050031Q000150
has primary subject term: D013964Q000473
has subject term: D006801
has subject term: D000077273Q000473
has subject term: D060890
has subject term: D008679
has subject term: D059016
source: Head Neck Pathol. 2024-03-08;18(1):14.
volume: 18

Primary Oropharyngeal SMARCA4-Deficient Carcinoma: Expanding the Diagnostic Spectrum in Head and Neck Cancer.
pmid: 38457069
abstract: With the advent of molecular immunohistochemistry and next generation sequencing, Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex altered tumors have gained recognition recently. SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily B member 1 (SMARCB1) and SMARCA4 are the primary SWI/SNF components altered in several recently described undifferentiated malignancies in head and neck region with predilection for paranasal sinuses in SMARCB1-deficient tumors and nasal cavity in SMARCA4-deficient tumors. However, to the best of our knowledge, SMARCA4-deficient tumors of the oropharynx have not been described. We present an unusual case of SMARCA4-deficient carcinoma of the oropharynx (palatine tonsil) which is the first case in the literature, expanding the topographic distribution of SMARCA4-deficient tumors in the head and neck region and emphasizing the importance of BRG1 as an essential immunohistochemical marker for the diagnosis of this distinct entity.
rights: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12105-024-01614-9
doi: 10.1007/s12105-024-01614-9
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Pasricha S
      type: Person
      first name: Sunil
      last name: Pasricha
      member of: Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
  slot:
    index: 2
    item: Goyal S
      type: Person
      first name: Sumit
      last name: Goyal
      member of: Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
  slot:
    index: 3
    item: Kamboj M
      type: Person
      first name: Meenakshi
      last name: Kamboj
      member of: Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
  slot:
    index: 4
    item: Diwan H
      type: Person
      first name: Himanshi
      last name: Diwan
      member of: Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India. himanshidiwan89@gmail.com.
  slot:
    index: 5
    item: Gairola M
      type: Person
      first name: Munish
      last name: Gairola
      member of: Department of Radiation Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
  slot:
    index: 6
    item: Sethi JS
      type: Person
      first name: Jaskaran Singh
      last name: Sethi
      member of: Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
  slot:
    index: 7
    item: Gupta M
      type: Person
      first name: Manoj
      last name: Gupta
      member of: Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
  slot:
    index: 8
    item: Mehta A
      type: Person
      first name: Anurag
      last name: Mehta
      member of: Department of Laboratory & Transfusion Services and Director Research, Rajiv Gandhi Cancer Institute & Research Centre, Delhi, 110085, India.
created: 2024-3-8T12:42
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 Mar 08
created: 2024-3-8T11:11
e ISSN: 1936-0568
has issn l: 1936-055X
issue: 1
has NLM journal title abbreviation: Head Neck Pathol
publication name: Head and neck pathology
language: eng
has national library of medicine journal id: 101304010
derived from: NLM
pg: 16
has place of publication: United States
has primary subject term: D002277Q000473
has primary subject term: D006258Q000175
has subject term: D006801
has subject term: D009333Q000473
has subject term: D014408
has subject term: D004265Q000235
has subject term: D009687Q000235
has subject term: D014157Q000235
source: Head Neck Pathol. 2024-03-08;18(1):16.
volume: 18

α2-Antiplasmin is associated with macrophage activation and fibrin deposition in a macrophage activation syndrome mouse model.
pmid: 38457368
abstract: Macrophage activation syndrome (MAS) is a life-threatening condition, characterized by cytopenia, multi-organ dysfunction, and coagulopathy associated with excessive activation of macrophages. In this study, we investigated the roles of alpha2-antiplasmin (α2AP) in the progression of MAS using fulminant MAS mouse model induced by toll-like receptor-9 agonist (CpG) and D-(+)-galactosamine hydrochloride (DG). α2AP deficiency attenuated macrophage accumulation, liver injury, and fibrin deposition in the MAS model mice. Interferon-γ (IFN-γ) is associated with macrophage activation, including migration, and plays a pivotal role in MAS progression. α2AP enhanced the IFN-γ-induced migration, and tissue factor production. Additionally, we showed that fibrin-induced macrophage activation and tumor necrosis factor-α production. Moreover, the blockade of α2AP by neutralizing antibodies attenuated macrophage accumulation, liver injury, and fibrin deposition in the MAS model mice. These data suggest that α2AP may regulate IFN-γ-induced responses and be associated with macrophage activation and fibrin deposition in the MAS progression.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7624590
doi: 10.1093/cei/uxae021
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kanno Y
      type: Person
      first name: Yosuke
      last name: Kanno
      member of: Department of Molecular Pathology, Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts, Kodo Kyo-tanabe, Kyoto, Japan.
  slot:
    index: 2
    item: Toyama K
      type: Person
      first name: Kinomi
      last name: Toyama
      member of: Department of Molecular Pathology, Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts, Kodo Kyo-tanabe, Kyoto, Japan.
  slot:
    index: 3
    item: Shibata H
      type: Person
      first name: Haruna
      last name: Shibata
      member of: Department of Molecular Pathology, Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts, Kodo Kyo-tanabe, Kyoto, Japan.
  slot:
    index: 4
    item: Matsuo O
      type: Person
      first name: Osamu
      last name: Matsuo
      member of: Faculty of Medicine, Kindai University, Osaka-sayama, Japan.
  slot:
    index: 5
    item: Ozaki KI
      type: Person
      first name: Kei-Ichi
      last name: Ozaki
      member of: Department of Molecular Pathology, Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts, Kodo Kyo-tanabe, Kyoto, Japan.
created: 2024-3-8T18:42
date last updated: 2025-03-09
issued: 2024-05-16
dp: 2024 May 16
created: 2024-3-8T13:22
e ISSN: 1365-2249
has issn l: 0009-9104
issue: 3
has NLM journal title abbreviation: Clin Exp Immunol
publication name: Clinical and experimental immunology
language: eng
has national library of medicine journal id: 0057202
derived from: NLM
starting page: 272
ending page: 279
has place of publication: England
has primary subject term: D000979Q000378
has primary subject term: D005337Q000378
has primary subject term: D008262Q000276
has primary subject term: D055501Q000276
has primary subject term: D008264Q000276Q000378
has subject term: D000818
has subject term: D008297
has subject term: D051379
has subject term: D004195
has subject term: D005688
has subject term: D007371Q000378
has subject term: D008099Q000276Q000378Q000473
has subject term: D008810
has subject term: D018345
has subject term: D014409Q000378
source: Clin Exp Immunol. 2024-05-16;216(3):272-279.
volume: 216

Comparisons of Hounsfield units and volumetric bone density in discriminating vertebral fractures on lumbar CT scans.
pmid: 38457607
abstract: To compare the performance of areal Hounsfield units (aHUs), volumetric Hounsfield units (vHUs), and volumetric bone mineral density (vBMD) by quantitative CT (QCT) in discriminating vertebral fractures (VFs) risk.We retrospectively included CT scans of the lumbar spine 101 VFs cases (60 women, mean age: 64 ± 4 years; 41 men, mean age: 73 ± 10 years) and sex- and age-matched 101 control subjects (60 women, mean age: 64 ± 4 years; 41 men, mean age: 72 ± 7 years). In order to assess the discriminatory capability of aHU, vHU, and vBMD measurements at the L1 and L2 levels in identifying VFs, we conducted binary logistic regression and receiver operating characteristic (ROC) curve analyses in men and women. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.In both men and women with and without VFs, aHU, vHU, and vBMD were highly correlated with each other (r2 from 0.832 to 0.957, all P < .001). There was a statistically significant difference in aHU, vHU, and vBMD between subjects with and without VFs (P < .001). When age, gender, and BMI were taken into account as covariances and adjusted simultaneously, odds ratios (ORs) for aHU, vHU, and vBMD values, which represent the risk of VFs, were significant (P < .001). Compared with aHU and vHU, vBMD was more strongly associated with VF risk (vBMD: OR, 6.29; 95% CI, 3.83-10.35 vs vHU: OR, 3.64; 95% CI, 2.43-5.46 vs aHU: OR, 2.56; 95% CI, 1.79-3.67). In both men and women, further, vBMD had higher values for AUC, sensitivity, specificity, PPV, and NPV compared to vHU, with vHU in turn surpassing aHU. The area under the receiver operating characteristic curve (AUC) for discriminating VFs using the average aHU, vHU, and vBMD of 2 vertebrae was 0.72, 0.77, and 0.87 in men and 0.76, 0.79, and 0.86 in women. In both men and women, there exist statistically significant differences in the AUC when employing the 3 measurements-namely, aHU, vHU, and vBMD-to discriminate frac[cell cut: 2779 characters, first 2000 kept]
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
has PII: 7624623
doi: 10.1093/bjr/tqae053
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Zhou F
      type: Person
      first name: Fengyun
      last name: Zhou
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 2
    item: Zhang W
      type: Person
      first name: Wenshuang
      last name: Zhang
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 3
    item: Geng J
      type: Person
      first name: Jian
      last name: Geng
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 4
    item: Liu Y
      type: Person
      first name: Yandong
      last name: Liu
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 5
    item: Yuan Y
      type: Person
      first name: Yi
      last name: Yuan
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 6
    item: Ma K
      type: Person
      first name: Kangkang
      last name: Ma
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 7
    item: Cheng Z
      type: Person
      first name: Zitong
      last name: Cheng
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 8
    item: Huang P
      type: Person
      first name: Pengju
      last name: Huang
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 9
    item: Cheng X
      type: Person
      first name: Xiaoguang
      last name: Cheng
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 10
    item: Wang L
      type: Person
      first name: Ling
      last name: Wang
      member of: Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.JST sarcopenia Research Centre, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
  slot:
    index: 11
    item: Liu Y
      type: Person
      first name: Yajun
      last name: Liu
      member of: JST sarcopenia Research Centre, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
created: 2024-3-8T18:42
date last updated: 2025-03-09
issued: 2024-05-07
dp: 2024 May 07
created: 2024-3-8T14:32
e ISSN: 1748-880X
has issn l: 0007-1285
issue: 1157
has NLM journal title abbreviation: Br J Radiol
publication name: The British journal of radiology
language: eng
has national library of medicine journal id: 0373125
derived from: NLM
starting page: 1003
ending page: 1009
has place of publication: England
has primary subject term: D016103Q000000981
has primary subject term: D015519
has primary subject term: D008159Q000000981
has primary subject term: D014057Q000379
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000368
has subject term: D008875
has subject term: D012189
has subject term: D012680
has subject term: D012372
has subject term: D016022
source: Br J Radiol. 2024-05-07;97(1157):1003-1009.
volume: 97

RaptGen-Assisted Generation of an RNA/DNA Hybrid Aptamer against SARS-CoV-2 Spike Protein.
pmid: 38457656
abstract: Optimization of aptamers in length and chemistry is crucial for industrial applications. Here, we developed aptamers against the SARS-CoV-2 spike protein and achieved optimization with a deep-learning-based algorithm, RaptGen. We conducted a primer-less SELEX against the receptor binding domain (RBD) of the spike with an RNA/DNA hybrid library, and the resulting sequences were subjected to RaptGen analysis. Based on the sequence profiling by RaptGen, a short truncation aptamer of 26 nucleotides was obtained and further optimized by a chemical modification of relevant nucleotides. The resulting aptamer is bound to RBD not only of SARS-CoV-2 wildtype but also of its variants, SARS-CoV-1, and Middle East respiratory syndrome coronavirus (MERS-CoV). We concluded that the RaptGen-assisted discovery is efficient for developing optimized aptamers.
doi: 10.1021/acs.biochem.3c00596
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Adachi T
      type: Person
      first name: Tatsuo
      last name: Adachi
      member of: RIBOMIC Inc., 3-16-13 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan.
  slot:
    index: 2
    item: Nakamura S
      type: Person
      first name: Shigetaka
      last name: Nakamura
      member of: RIBOMIC Inc., 3-16-13 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan.
  slot:
    index: 3
    item: Michishita A
      type: Person
      first name: Akiya
      last name: Michishita
      member of: Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan.Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology (AIST), 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan.
  slot:
    index: 4
    item: Kawahara D
      type: Person
      first name: Daiki
      last name: Kawahara
      member of: RIBOMIC Inc., 3-16-13 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan.
  slot:
    index: 5
    item: Yamamoto M
      type: Person
      first name: Mizuki
      last name: Yamamoto
      member of: Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  slot:
    index: 6
    item: Hamada M
      type: Person
      first name: Michiaki
      last name: Hamada
      member of: Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan.Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology (AIST), 3-4-1, Okubo Shinjuku-ku, Tokyo 169-8555, Japan.
  slot:
    index: 7
    item: Nakamura Y
      type: Person
      first name: Yoshikazu
      last name: Nakamura
      member of: RIBOMIC Inc., 3-16-13 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan.The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
created: 2024-3-8T18:42
date last updated: 2025-03-09
issued: 2024-04-02
dp: 2024 04 02
created: 2024-3-8T15:13
e ISSN: 1520-4995
has issn l: 0006-2960
issue: 7
has NLM journal title abbreviation: Biochemistry
publication name: Biochemistry
language: eng
has national library of medicine journal id: 0370623
derived from: NLM
starting page: 906
ending page: 912
has place of publication: United States
has primary subject term: D052157
has primary subject term: D000086402Q000737Q000235
has subject term: D006801
has subject term: D000086382Q000517
has subject term: D004247
has subject term: D064370Q000235Q000737
source: Biochemistry. 2024-04-02;63(7):906-912.
volume: 63

EIF4A3-negatively driven circular RNA β-catenin (circβ-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis.
pmid: 38459187
abstract: Circβ-catenin, our first reported circRNA, has been reported to mediate tumorigenesis in various cancers. However, its biological functions and underlying mechanisms in colorectal cancer (CRC) remain unknown.The qRT-PCR examination was used to detect the expression of circβ-catenin, miR-197-3p, and CTNND1 in cells and human tissues. Western blot was conducted to detect the protein expression levels. The biological function of circβ-catenin was verified by MTT, colony formation, wound healing, and transwell assays. The in vivo effects of circβ-catenin were verified by nude mice xenograft and metastasis models. The regulatory network of circβ-catenin/miR-197-3p/CTNND1 was confirmed via dual-luciferase reporter and RIP assays.In the present study, circβ-catenin was found to promote CRC cell proliferation and metastasis in vitro and in vivo. Mechanistically, circβ-catenin served as miRNA decoy to directly bind to miR-197-3p, then antagonized the repression of the target gene CTNND1, and eventually promoted the malignant phenotype of CRC. More interestingly, the inverted repeated Alu pairs termed AluJb1/2 and AluY facilitated the biogenesis of circβ-catenin, which could be partially reversed by EIF4A3 binding to Alu element AluJb2.Our findings illustrated a novel mechanism of circβ-catenin in modulating CRC tumorigenesis and metastasis, which provides a potential therapeutic target for CRC patients.
rights: © 2024. The Author(s), under exclusive licence to Springer Nature Limited.
has PII: 10.1038/s41416-024-02612-y
doi: 10.1038/s41416-024-02612-y
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Deng LQ
      type: Person
      first name: Li-Qiang
      last name: Deng
      member of: Cancer center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.Research Institute, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China.
  slot:
    index: 2
    item: Shi CJ
      type: Person
      first name: Chuan-Jian
      last name: Shi
      member of: Cancer center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.Research Institute, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China.
  slot:
    index: 3
    item: Zhou ST
      type: Person
      first name: Shu-Ting
      last name: Zhou
      member of: Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
  slot:
    index: 4
    item: Zeng WQ
      type: Person
      first name: Wei-Qiang
      last name: Zeng
      member of: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  slot:
    index: 5
    item: Xian YF
      type: Person
      first name: Yan-Fang
      last name: Xian
      member of: School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
  slot:
    index: 6
    item: Wang YY
      type: Person
      first name: Yu-Yan
      last name: Wang
      member of: Cancer center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China.
  slot:
    index: 7
    item: Fu WM
      type: Person
      first name: Wei-Ming
      last name: Fu
      member of: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  slot:
    index: 8
    item: Lin HL
      type: Person
      first name: Han-Li
      last name: Lin
      member of: Research Institute, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China. linhanli2010@163.com.
  slot:
    index: 9
    item: Liu W
      type: Person
      first name: Wei
      last name: Liu
      member of: Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. liuwei@gzucm.edu.cn.
  slot:
    index: 10
    item: Zhang JF
      type: Person
      first name: Jin-Fang
      last name: Zhang
      member of: Cancer center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China. zhangjf06@gzucm.edu.cn.Research Institute, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China. zhangjf06@gzucm.edu.cn.Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. zhangjf06@gzucm.edu.cn.
created: 2024-3-9T10:42
date last updated: 2025-03-09
issued: 2024-05
dp: 2024 May
created: 2024-3-8T23:33
e ISSN: 1532-1827
has issn l: 0007-0920
issue: 9
has NLM journal title abbreviation: Br J Cancer
publication name: British journal of cancer
language: eng
has national library of medicine journal id: 0370635
derived from: NLM
starting page: 1517
ending page: 1528
has place of publication: England
has primary subject term: D035683Q000235
has primary subject term: D015179Q000235Q000473Q000378
has primary subject term: D000079962Q000235
has primary subject term: D051176Q000378Q000235
has primary subject term: D008819
has primary subject term: D049109Q000235
has primary subject term: D018450
has primary subject term: D039601Q000235Q000378
has subject term: D006801
has subject term: D000818
has subject term: D051379
has subject term: http://id.nlm.nih.gov/mesh/D000095002
has subject term: D015972
has subject term: D045744
has subject term: D008297
has subject term: D005260
has subject term: D002465Q000235
has subject term: D008807
source: Br J Cancer. 2024-05;130(9):1517-1528.
volume: 130

Mendelian randomization analysis using multiple biomarkers of an underlying common exposure.
pmid: 38459704
abstract: Mendelian randomization (MR) analysis is increasingly popular for testing the causal effect of exposures on disease outcomes using data from genome-wide association studies. In some settings, the underlying exposure, such as systematic inflammation, may not be directly observable, but measurements can be available on multiple biomarkers or other types of traits that are co-regulated by the exposure. We propose a method for MR analysis on latent exposures (MRLE), which tests the significance for, and the direction of, the effect of a latent exposure by leveraging information from multiple related traits. The method is developed by constructing a set of estimating functions based on the second-order moments of GWAS summary association statistics for the observable traits, under a structural equation model where genetic variants are assumed to have indirect effects through the latent exposure and potentially direct effects on the traits. Simulation studies show that MRLE has well-controlled type I error rates and enhanced power compared to single-trait MR tests under various types of pleiotropy. Applications of MRLE using genetic association statistics across five inflammatory biomarkers (CRP, IL-6, IL-8, TNF-α, and MCP-1) provide evidence for potential causal effects of inflammation on increasing the risk of coronary artery disease, colorectal cancer, and rheumatoid arthritis, while standard MR analysis for individual biomarkers fails to detect consistent evidence for such effects.
rights: © The Author 2024. Published by Oxford University Press. All rights reserved. For Permissions, email: journals.permissions@oup.com.
has PII: 7624600
doi: 10.1093/biostatistics/kxae006
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Jin J
      type: Person
      first name: Jin
      last name: Jin
      member of: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United States.Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104-6021, United States.
  slot:
    index: 2
    item: Qi G
      type: Person
      first name: Guanghao
      last name: Qi
      member of: Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, United States.Department of Biostatistics, University of Washington, 3980 15th Avenue NE, Seattle, WA 98195-1617, United States.
  slot:
    index: 3
    item: Yu Z
      type: Person
      first name: Zhi
      last name: Yu
      member of: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 415 Main St Cambridge, MA 02142, United States.
  slot:
    index: 4
    item: Chatterjee N
      type: Person
      first name: Nilanjan
      last name: Chatterjee
      member of: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United States.Department of Oncology, School of Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, United States.
created: 2024-3-9T10:44
date last updated: 2025-03-09
issued: 2024-10-01
dp: 2024 Oct 01
created: 2024-3-9T02:08
e ISSN: 1468-4357
has issn l: 1465-4644
issue: 4
has NLM journal title abbreviation: Biostatistics
publication name: Biostatistics (Oxford, England)
language: eng
has national library of medicine journal id: 100897327
derived from: NLM
starting page: 1015
ending page: 1033
has place of publication: England
has primary subject term: D057182Q000379
has primary subject term: D015415Q000097
has primary subject term: D055106Q000379
has subject term: D006801
has subject term: D007249Q000235
has subject term: D015233
source: Biostatistics. 2024-10-01;25(4):1015-1033.
volume: 25

Systematic evaluation of MRI-based characterization of tumor-associated vascular morphology and hemodynamics via a dynamic digital phantom.
pmid: 38463607
abstract: Validation of quantitative imaging biomarkers is a challenging task, due to the difficulty in measuring the ground truth of the target biological process. A digital phantom-based framework is established to systematically validate the quantitative characterization of tumor-associated vascular morphology and hemodynamics based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).A digital phantom is employed to provide a ground-truth vascular system within which 45 synthetic tumors are simulated. Morphological analysis is performed on high-spatial resolution DCE-MRI data (spatial/temporal resolution = 30 to 300 μm/60 s) to determine the accuracy of locating the arterial inputs of tumor-associated vessels (TAVs). Hemodynamic analysis is then performed on the combination of high-spatial resolution and high-temporal resolution (spatial/temporal resolution = 60 to 300 μm/1 to 10 s) DCE-MRI data, determining the accuracy of estimating tumor-associated blood pressure, vascular extraction rate, interstitial pressure, and interstitial flow velocity.The observed effects of acquisition settings demonstrate that, when optimizing the DCE-MRI protocol for the morphological analysis, increasing the spatial resolution is helpful but not necessary, as the location and arterial input of TAVs can be recovered with high accuracy even with the lowest investigated spatial resolution. When optimizing the DCE-MRI protocol for hemodynamic analysis, increasing the spatial resolution of the images used for vessel segmentation is essential, and the spatial and temporal resolutions of the images used for the kinetic parameter fitting require simultaneous optimization.An in silico validation framework was generated to systematically quantify the effects of image acquisition settings on the ability to accurately estimate tumor-associated characteristics.
rights: © 2024 Society of Photo-Optical Instrumentation Engineers (SPIE).
has PII: 23149GR
doi: 10.1117/1.JMI.11.2.024002
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Wu C
      type: Person
      first name: Chengyue
      last name: Wu
      member of: University of Texas at Austin, Oden Institute for Computational Engineering and Sciences, Austin, Texas, United States.MD Anderson Cancer Center, Department of Imaging Physics, Houston, Texas, United States.MD Anderson Cancer Center, Department of Breast Imaging, Houston, Texas, United States.MD Anderson Cancer Center, Department of Breast Imaging, Houston, Texas, United States.MD Anderson Cancer Center, Department of Biostatistics, Houston, Texas, United States.
  slot:
    index: 2
    item: Hormuth DA
      type: Person
      first name: David A
      last name: Hormuth
      member of: University of Texas at Austin, Oden Institute for Computational Engineering and Sciences, Austin, Texas, United States.University of Texas at Austin, Livestrong Cancer Institutes, Austin, Texas, United States.
  slot:
    index: 3
    item: Easley T
      type: Person
      first name: Ty
      last name: Easley
      member of: Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States.
  slot:
    index: 4
    item: Pineda F
      type: Person
      first name: Federico
      last name: Pineda
      member of: University of Chicago, Department of Radiology, Chicago, Illinois, United States.
  slot:
    index: 5
    item: Karczmar GS
      type: Person
      first name: Gregory S
      last name: Karczmar
      member of: University of Chicago, Department of Radiology, Chicago, Illinois, United States.
  slot:
    index: 6
    item: Yankeelov TE
      type: Person
      first name: Thomas E
      last name: Yankeelov
      member of: University of Texas at Austin, Oden Institute for Computational Engineering and Sciences, Austin, Texas, United States.MD Anderson Cancer Center, Department of Imaging Physics, Houston, Texas, United States.University of Texas at Austin, Livestrong Cancer Institutes, Austin, Texas, United States.University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas, United States.University of Texas at Austin, Department of Diagnostic Medicine, Austin, Texas, United States.University of Texas at Austin, Department of Oncology, Austin, Texas, United States.
created: 2024-3-11T06:42
date last updated: 2025-03-09
issued: 2024-03
dp: 2024 Mar
created: 2024-3-11T04:23
ISSN: 2329-4302
has issn l: 2329-4302
issue: 2
has NLM journal title abbreviation: J Med Imaging (Bellingham)
publication name: Journal of medical imaging (Bellingham, Wash.)
language: eng
has national library of medicine journal id: 101643461
derived from: NLM
pg: 024002
has place of publication: United States
source: J Med Imaging (Bellingham). 2024-03;11(2):024002.
volume: 11

From the Editor-in-Chief.
pmid: 38465359
has PII: 10.1177_24741264241234111
doi: 10.1177/24741264241234111
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Murray TG
      type: Person
      first name: Timothy G
      last name: Murray
created: 2024-3-11T06:44
date last updated: 2025-03-09
created: 2024-3-11T04:50
e ISSN: 2474-1272
has issn l: 2474-1264
issue: 2
has NLM journal title abbreviation: J Vitreoretin Dis
publication name: Journal of vitreoretinal diseases
language: eng
has national library of medicine journal id: 101700301
derived from: NLM
starting page: 121
ending page: 124
has place of publication: United States
source: J Vitreoretin Dis. ;8(2):121-124.
volume: 8

Addressing Mental Health Barriers in HIV Care Coordination Is Crucial to Providing Optimal HIV/AIDS Care.
pmid: 38471091
abstract: For people with HIV (PWH) who have psychological comorbidities, effective management of mental health issues is crucial to achieving and maintaining viral suppression. Care coordination programs (CCPs) have been shown to improve outcomes across the HIV care continuum, but little research has focused on the role of care coordination in supporting the mental health of PWH. This study reports qualitative findings from the Program Refinements to Optimize Model Impact and Scalability based on Evidence (PROMISE) study, which evaluated a revised version of an HIV CCP for Ryan White Part A clients in New York City. Semistructured interviews were conducted with 30 providers and 27 clients from 6 CCP-implementing agencies to elucidate barriers and facilitators of program engagement. Transcripts were analyzed for key themes related to clients' mental health needs and providers' successes and challenges in meeting these needs. Providers and clients agreed that insufficiently managed mental health issues are a common barrier to achieving and maintaining viral suppression. Although the CCP model calls for providers to address clients' unmet mental health needs primarily through screening and referrals to psychiatric and/or psychological care, both clients and providers reported that the routine provision of emotional support is a major part of providers' role that is highly valued by clients. Some concerns raised by providers included insufficient training to address clients' mental health needs and an inability to document the provision of emotional support as a delivered service. These findings suggest the potential value of formally integrating mental health services into HIV care coordination provision. ClinicalTrials.gov protocol number: NCT03628287.
doi: 10.1089/apc.2023.0240
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Hernandez M
      type: Person
      first name: Miguel
      last name: Hernandez
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 2
    item: Guarino H
      type: Person
      first name: Honoria
      last name: Guarino
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 3
    item: Kozlowski S
      type: Person
      first name: Sarah
      last name: Kozlowski
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 4
    item: Srivastava A
      type: Person
      first name: Avantika
      last name: Srivastava
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 5
    item: Schenkel R
      type: Person
      first name: Rachel
      last name: Schenkel
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 6
    item: Tapia T
      type: Person
      first name: Thamara
      last name: Tapia
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 7
    item: Seabrook TB
      type: Person
      first name: Tyeirra B
      last name: Seabrook
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 8
    item: Nash D
      type: Person
      first name: Denis
      last name: Nash
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
  slot:
    index: 9
    item: Irvine MK
      type: Person
      first name: Mary K
      last name: Irvine
      member of: Institute for Implementation Science in Population Health (ISPH), CUNY Graduate School of Public Health & Health Policy, New York, New York, USA.
created: 2024-3-12T18:42
date last updated: 2025-03-09
issued: 2024-03
dp: 2024 03
created: 2024-3-12T16:53
e ISSN: 1557-7449
has issn l: 1087-2914
issue: 3
has NLM journal title abbreviation: AIDS Patient Care STDS
publication name: AIDS patient care and STDs
language: eng
has national library of medicine journal id: 9607225
derived from: NLM
starting page: 107
ending page: 114
has place of publication: United States
has primary subject term: D015658Q000523
has primary subject term: D008605
has subject term: D006801
has subject term: D003266
has subject term: D003376
has subject term: D008603
source: AIDS Patient Care STDS. 2024-03;38(3):107-114.
volume: 38

Morpho-functional analysis of the temporomandibular joint following mandible-first bimaxillary surgery with mandible-only patient-specific implants.
pmid: 38485626
abstract: The aim of this study was to evaluate condylar and glenoid fossa remodeling after bimaxillary orthognathic surgery guided by patient-specific mandibular implants. In total, 18 patients suffering from dentofacial dysmorphism underwent a virtually planned bimaxillary mandibular PSI-guided orthognathic procedure. One month prior to surgery, patients underwent a CBCT scan and optical scans of the dental arches; these datasets were re-acquired 1 month and at least 9 months postsurgery. Three-dimensional models of the condyles, glenoid fossae, and interarticular surface space (IASS) were obtained and compared to evaluate the roto-translational positional discrepancy and surface variation of each condyle and glenoid fossa, and the IASS variation. The condylar position varied by an average of 4.31° and 2.18 mm, mainly due to surgically unavoidable ramus position correction. Condylar resorption remodeling was minimal (average ≤ 0.1 mm), and affected skeletal class III patients the most. Later condylar remodeling was positively correlated with patient age. No significant glenoid fossa remodeling was observed. No postoperative orofacial pain was recorded at clinical follow-up. The procedure was accurate in minimizing the shift in relationship between the bony components of the TMJ and their remodeling, and was effective in avoiding postoperative onset of orofacial pain. An increase in sample size, however, would be useful to confirm our findings.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1010-5182(24)00058-1
doi: 10.1016/j.jcms.2024.02.009
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Bevini M
      type: Person
      first name: Mirko
      last name: Bevini
      member of: Oral and Maxillo-Facial Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy. Electronic address: mirko.bevini@studio.unibo.it.
  slot:
    index: 2
    item: Gulotta C
      type: Person
      first name: Chiara
      last name: Gulotta
      member of: Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum - University of Bologna, Italy. Electronic address: chiara.gulotta@studio.unibo.it.
  slot:
    index: 3
    item: Lunari O
      type: Person
      first name: Ottavia
      last name: Lunari
      member of: School of Medecine, Alma Mater Studiorum, University of Bologna, Italy. Electronic address: ottavia.lunari@studio.unibo.it.
  slot:
    index: 4
    item: Cercenelli L
      type: Person
      first name: Laura
      last name: Cercenelli
      member of: Laboratory of Bioengineering-eDIMES Lab, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Italy. Electronic address: laura.cercenelli@unibo.it.
  slot:
    index: 5
    item: Marcelli E
      type: Person
      first name: Emanuela
      last name: Marcelli
      member of: Laboratory of Bioengineering-eDIMES Lab, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Italy. Electronic address: emanuela.marcelli@unibo.it.
  slot:
    index: 6
    item: Felice P
      type: Person
      first name: Pietro
      last name: Felice
      member of: Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum - University of Bologna, Italy. Electronic address: pietro.felice@unibo.it.
  slot:
    index: 7
    item: Tarsitano A
      type: Person
      first name: Achille
      last name: Tarsitano
      member of: Oral and Maxillo-Facial Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum - University of Bologna, Italy. Electronic address: achille.tarsitano2@unibo.it.
  slot:
    index: 8
    item: Badiali G
      type: Person
      first name: Giovanni
      last name: Badiali
      member of: Oral and Maxillo-Facial Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum - University of Bologna, Italy. Electronic address: giovanni.badiali@unibo.it.
created: 2024-3-15T00:43
date last updated: 2025-03-08
issued: 2024-05
dp: 2024 May
created: 2024-3-14T23:01
e ISSN: 1878-4119
has issn l: 1010-5182
issue: 5
has NLM journal title abbreviation: J Craniomaxillofac Surg
publication name: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
language: eng
has national library of medicine journal id: 8704309
derived from: NLM
starting page: 570
ending page: 577
has place of publication: Scotland
has primary subject term: D013704Q000000981Q000601
has primary subject term: D056948Q000379
has primary subject term: D054893
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000328
has subject term: D008334Q000601Q000000981
has subject term: D008335Q000000981Q000601Q000473
has subject term: D055815
has subject term: D016723Q000502
has subject term: D021621Q000379
has subject term: D008437Q000601Q000000981
has subject term: D000293
has subject term: D061165Q000000981Q000473Q000601
source: J Craniomaxillofac Surg. 2024-05;52(5):570-577.
volume: 52

Dominant NARS1 mutations causing axonal Charcot-Marie-Tooth disease expand NARS1-associated diseases.
pmid: 38495304
abstract: Pathogenic variants in six aminoacyl-tRNA synthetase (ARS) genes are implicated in neurological disorders, most notably inherited peripheral neuropathies. ARSs are enzymes that charge tRNA molecules with cognate amino acids. Pathogenic variants in asparaginyl-tRNA synthetase (NARS1) cause a neurological phenotype combining developmental delay, ataxia and demyelinating peripheral neuropathy. NARS1 has not yet been linked to axonal Charcot-Marie-Tooth disease. Exome sequencing of patients with inherited peripheral neuropathies revealed three previously unreported heterozygous NARS1 variants in three families. Clinical and electrophysiological details were assessed. We further characterized all three variants in a yeast complementation model and used a knock-in mouse model to study variant p.Ser461Phe. All three variants (p.Met236del, p.Cys342Tyr and p.Ser461Phe) co-segregate with the sensorimotor axonal neuropathy phenotype. Yeast complementation assays show that none of the three NARS1 variants support wild-type yeast growth when tested in isolation (i.e. in the absence of a wild-type copy of NARS1), consistent with a loss-of-function effect. Similarly, the homozygous knock-in mouse model (p.Ser461Phe/Ser472Phe in mouse) also demonstrated loss-of-function characteristics. We present three previously unreported NARS1 variants segregating with a sensorimotor neuropathy phenotype in three families. Functional studies in yeast and mouse support variant pathogenicity. Thus, NARS1 is the seventh ARS implicated in dominant axonal Charcot-Marie-Tooth disease, further stressing that all dimeric ARSs should be evaluated for Charcot-Marie-Tooth disease.
rights: © Crown copyright 2024.
has PII: fcae070
doi: 10.1093/braincomms/fcae070
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Beijer D
      type: Person
      first name: Danique
      last name: Beijer
      member of: Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, B-2610, Belgium.Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Wilrijk, B-2610, Belgium.Department for Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL 33136, USA.
  slot:
    index: 2
    item: Marte S
      type: Person
      first name: Sheila
      last name: Marte
      member of: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  slot:
    index: 3
    item: Li JC
      type: Person
      first name: Jiaxin C
      last name: Li
      member of: The Jackson Laboratory, Bar Harbor, ME 04609, USA.Genetics Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
  slot:
    index: 4
    item: De Ridder W
      type: Person
      first name: Willem
      last name: De Ridder
      member of: Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, B-2610, Belgium.Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Wilrijk, B-2610, Belgium.Neuromuscular Reference Centre, Department of Neurology, Antwerp University Hospital, Wilrijk, B-2610, Belgium.
  slot:
    index: 5
    item: Chen JZ
      type: Person
      first name: Jessie Z
      last name: Chen
      member of: Department of Neurology, Austin Health, Melbourne, VIC 3084, Australia.
  slot:
    index: 6
    item: Tadenev ALD
      type: Person
      first name: Abigail L D
      last name: Tadenev
      member of: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  slot:
    index: 7
    item: Miers KE
      type: Person
      first name: Kathy E
      last name: Miers
      member of: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  slot:
    index: 8
    item: Deconinck T
      type: Person
      first name: Tine
      last name: Deconinck
      member of: Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, B-2610, Belgium.Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Edegem, B-2650, Belgium.
  slot:
    index: 9
    item: Macdonell R
      type: Person
      first name: Richard
      last name: Macdonell
      member of: Department of Neurology, Austin Health, Melbourne, VIC 3084, Australia.
  slot:
    index: 10
    item: Marques W
      type: Person
      first name: Wilson
      last name: Marques
      member of: Department of Neurosciences and Behavior Sciences, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, SP, 14051-140, Brazil.
  slot:
    index: 11
    item: De Jonghe P
      type: Person
      first name: Peter
      last name: De Jonghe
      member of: Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, B-2610, Belgium.Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Wilrijk, B-2610, Belgium.Neuromuscular Reference Centre, Department of Neurology, Antwerp University Hospital, Wilrijk, B-2610, Belgium.
  slot:
    index: 12
    item: Pratt SL
      type: Person
      first name: Samia L
      last name: Pratt
      member of: The Jackson Laboratory, Bar Harbor, ME 04609, USA.Neuroscience Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
  slot:
    index: 13
    item: Meyer-Schuman R
      type: Person
      first name: Rebecca
      last name: Meyer-Schuman
      member of: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  slot:
    index: 14
    item: Züchner S
      type: Person
      first name: Stephan
      last name: Züchner
      member of: Department for Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL 33136, USA.
  slot:
    index: 15
    item: Antonellis A
      type: Person
      first name: Anthony
      last name: Antonellis
      member of: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.Department of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  slot:
    index: 16
    item: Burgess RW
      type: Person
      first name: Robert W
      last name: Burgess
      member of: The Jackson Laboratory, Bar Harbor, ME 04609, USA.Genetics Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.Neuroscience Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
  slot:
    index: 17
    item: Baets J
      type: Person
      first name: Jonathan
      last name: Baets
      member of: Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, B-2610, Belgium.Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Wilrijk, B-2610, Belgium.Neuromuscular Reference Centre, Department of Neurology, Antwerp University Hospital, Wilrijk, B-2610, Belgium.
created: 2024-3-18T06:43
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-3-18T04:18
e ISSN: 2632-1297
has issn l: 2632-1297
issue: 2
has NLM journal title abbreviation: Brain Commun
publication name: Brain communications
language: eng
has national library of medicine journal id: 101755125
derived from: NLM
pg: fcae070
has place of publication: England
source: Brain Commun. 2024;6(2):fcae070.
volume: 6

Rome IV Clinical Criteria and Management of Functional Constipation: Indonesian Health Care Professionals' Perspective.
pmid: 38510582
abstract: The updated ROME IV criteria for functional constipation (FC) in children were published in 2016. However, information on the use of these criteria is scarce. This study aimed to report the frequency of the use of the ROME IV criteria by Indonesian pediatricians and general practitioners (GPs) in FC management in infants and toddlers.An anonymous cross-sectional online survey was conducted between November 2021 and March 2022.A total of 248 respondents (183 pediatricians and 65 GPs) from 24 Indonesian provinces completed the survey. Most respondents reported an estimated prevalence of FC to be less than 5% both in infants and toddlers. On average, only 64.6% of respondents frequently used the ROME IV criteria. Pediatricians used the ROME IV criteria more often than GPs did (p<0.001). The most frequently used criteria were painful or hard bowel movements (75.0%) and ≤2 defecations/week (71.4%). Lactulose as a laxative was the preferred treatment choice, followed by changing the standard formula to a specific nutritional formula. Most of the respondents carried out parenteral reassurance and education. Normal growth, as a marker of good digestion and absorption function, and normal stool consistency and frequency were the most reported indicators of gut health.The ROME IV criteria for functional constipation are not extensively used by pediatricians and GPs in Indonesia. Laxatives and specific nutritional formulas were the most used management approaches in infants and toddlers. Medical education, especially for general practitioners, should be updated.
rights: Copyright © 2024 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.
doi: 10.5223/pghn.2024.27.2.125
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Darma A
      type: Person
      first name: Andy
      last name: Darma
      member of: Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  slot:
    index: 2
    item: Sumitro KR
      type: Person
      first name: Khadijah Rizky
      last name: Sumitro
      member of: Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  slot:
    index: 3
    item: Muhardi L
      type: Person
      first name: Leilani
      last name: Muhardi
      member of: FrieslandCampina AMEA, Singapore, Singapore.
  slot:
    index: 4
    item: Vandenplas Y
      type: Person
      first name: Yvan
      last name: Vandenplas
      member of: Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium.
  slot:
    index: 5
    item: Hegar B
      type: Person
      first name: Badriul
      last name: Hegar
      member of: Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
created: 2024-3-21T06:43
date last updated: 2025-03-09
issued: 2024-03
dp: 2024 Mar
created: 2024-3-21T04:12
ISSN: 2234-8646
has issn l: 2234-8840
issue: 2
has NLM journal title abbreviation: Pediatr Gastroenterol Hepatol Nutr
publication name: Pediatric gastroenterology, hepatology & nutrition
language: eng
has national library of medicine journal id: 101590471
derived from: NLM
starting page: 125
ending page: 135
has place of publication: Korea (South)
source: Pediatr Gastroenterol Hepatol Nutr. 2024-03;27(2):125-135.
volume: 27

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children.
pmid: 38515948
abstract: The detection rate of peptic ulcer in children is improving, with development of diagnostic procedures. Gastroscopy is the gold standard for the diagnosis of peptic ulcer, but it is an invasive procedure. Gastrointestinal contrast-enhanced ultrasonography (CEUS) has the advantages of being painless, noninvasive, nonradioactive, easy to use, and safe.To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in children.We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June 2022. All children were examined by routine ultrasound, gastrointestinal CEUS, and gastroscopy. The pathological results of gastroscopy were taken as the gold standard. Routine ultrasonography was performed before gastrointestinal CEUS. Conventional ultrasound showed the thickness of the gastroduodenal wall, gastric peristalsis, and the adjacent organs and tissues around the abdominal cavity. Gastrointestinal CEUS recorded the thickness of the gastroduodenal wall; the size, location and shape of the ulcer; gastric peristalsis; and adjacent organs and tissues around the abdominal cavity. The results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal CEUS. All children received informed consent from their guardians for CEUS. This study was reviewed and approved by the hospital medical ethics committee.Among the 43 children, 17 (15 male, 2 female) were diagnosed with peptic ulcer by gastroscopy. There were 26 children with nonpeptic ulcer. There were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional ultrasound. The diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1% (34/43), which was significantly different from that of gastroscopy (P = 0.033). It indicates that the coincidence rate of gastrointestinal contras[cell cut: 2543 characters, first 2000 kept]
rights: ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.3748/wjg.v30.i7.705
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zhang YH
      type: Person
      first name: Yu-Hua
      last name: Zhang
      member of: Department of Ultrasound, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
  slot:
    index: 2
    item: Xu ZH
      type: Person
      first name: Zhi-Hua
      last name: Xu
      member of: Department of Ultrasound, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
  slot:
    index: 3
    item: Ni SS
      type: Person
      first name: Shuang-Shuang
      last name: Ni
      member of: Department of Ultrasound, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
  slot:
    index: 4
    item: Luo HX
      type: Person
      first name: Hong-Xia
      last name: Luo
      member of: Department of Ultrasound, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. luohongxia0127@163.com.
created: 2024-3-22T06:44
date last updated: 2025-03-09
issued: 2024-02-21
dp: 2024 Feb 21
created: 2024-3-22T04:02
e ISSN: 2219-2840
has issn l: 1007-9327
issue: 7
has NLM journal title abbreviation: World J Gastroenterol
publication name: World journal of gastroenterology
language: eng
has national library of medicine journal id: 100883448
derived from: NLM
starting page: 705
ending page: 713
has place of publication: United States
has primary subject term: D003287
has primary subject term: D010437Q000000981Q000628
has subject term: D002648
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D014456
has subject term: D014463Q000379
source: World J Gastroenterol. 2024-02-21;30(7):705-713.
volume: 30

Heterotopic Auxiliary Whole Liver Rat Transplant Model Utilizing a Hepaticoureterostomy for Allograft Rejection Studies.
pmid: 38526116
abstract: Small animal transplant models are indispensable for organ tolerance studies investigating feasible therapeutic interventions in preclinical studies. Rat liver transplantation (LTx) protocols typically use an orthotopic model where the recipients' native liver is removed and replaced with a donor liver. This technically demanding surgical procedure requires advanced micro-surgical skills and is further complicated by lengthy anhepatic and lower body ischemia times. This prompted the development of a less complicated heterotopic method that can be performed faster with no anhepatic or lower body ischemia time, reducing post-surgery stress for the recipient animal. This heterotopic LTx protocol includes two main steps: excising the liver from the donor rat and transplanting the whole liver into the recipient rat. During the excision of the donor liver, the surgeon ligates the supra-hepatic vena cava (SHVC) and hepatic artery (HA). On the recipient side, the surgeon removes the left kidney and positions the donor liver with the portal vein (PV), infra-hepatic vena cava (IHVC), and bile duct facing the renal vessels. Further, the surgeon anastomoses the recipient's renal vein end to end with the IHVC of the liver and arterializes the PV with the renal artery using a stent. A hepaticoureterostomy is utilized for biliary drainage by anastomosing the bile duct to the recipient's ureter, permitting the discharge of bile via the bladder. The average duration of the transplantation was 130 min, cold ischemia duration was around 35 min, and warm ischemia duration was less than 25 min. Hematoxylin and eosin histology of the auxiliary liver from syngeneic transplants showed normal hepatocyte structure with no significant parenchymal alterations 30 days post-transplant. In contrast, 8-day post-transplant allogeneic graft specimens demonstrated extensive lymphocytic infiltration with a Banff Schema rejection activity index score of 9. Therefore, this LTx method facilitates a low m[cell cut: 2055 characters, first 2000 kept]
doi: 10.3791/66516
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Verhoven B
      type: Person
      first name: Bret
      last name: Verhoven
      member of: Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison.
  slot:
    index: 2
    item: Zeng W
      type: Person
      first name: Weifeng
      last name: Zeng
      member of: Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Wisconsin.
  slot:
    index: 3
    item: Chlebeck P
      type: Person
      first name: Peter
      last name: Chlebeck
      member of: Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison.
  slot:
    index: 4
    item: Matkowskyj K
      type: Person
      first name: Kristina
      last name: Matkowskyj
      member of: Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison; UW Carbone Cancer Center; William S. Middleton Memorial Veterans' Hospital.
  slot:
    index: 5
    item: Jennings H
      type: Person
      first name: Heather
      last name: Jennings
      member of: Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison.
  slot:
    index: 6
    item: Poore S
      type: Person
      first name: Samuel
      last name: Poore
      member of: Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Wisconsin.
  slot:
    index: 7
    item: Al-Adra D
      type: Person
      first name: David
      last name: Al-Adra
      member of: Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison; aladra@wisc.edu.
created: 2024-3-25T12:43
date last updated: 2025-03-09
issued: 2024-03-08
dp: 2024 Mar 08
created: 2024-3-25T09:04
e ISSN: 1940-087X
has issn l: 1940-087X
issue: 205
has NLM journal title abbreviation: J Vis Exp
publication name: Journal of visualized experiments : JoVE
language: eng
has national library of medicine journal id: 101313252
derived from: NLM
has place of publication: United States
has primary subject term: D016031Q000379
has subject term: D051381
has subject term: D000818
has subject term: D006801
has subject term: D019520
has subject term: D008099Q000473
has subject term: D000714Q000379
has subject term: D007511Q000473
has subject term: D064591
source: J Vis Exp. 2024-03-08;(205):.

Editorial: Heparan sulfate-binding proteins in health and disease.
pmid: 38572447
has PII: 1386623
doi: 10.3389/fmolb.2024.1386623
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Gandy LA
      type: Person
      first name: Lauren A
      last name: Gandy
      member of: Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States.Glycobiology, Cell Growth and Tissue Repair Research Unit (Gly-CRRET), Université Paris-est Créteil, Créteil, France.
  slot:
    index: 2
    item: Zhang F
      type: Person
      first name: Fuming
      last name: Zhang
      member of: Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States.
  slot:
    index: 3
    item: Xu D
      type: Person
      first name: Ding
      last name: Xu
      member of: Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY, United States.
  slot:
    index: 4
    item: Pedersen LC
      type: Person
      first name: Lars C
      last name: Pedersen
      member of: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, United States.
  slot:
    index: 5
    item: Grobe K
      type: Person
      first name: Kay
      last name: Grobe
      member of: Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany.
  slot:
    index: 6
    item: Wang C
      type: Person
      first name: Chunyu
      last name: Wang
      member of: Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States.Department of Biology, Troy, NY, United States.Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, United States.
created: 2024-4-4T06:44
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-4-4T04:14
ISSN: 2296-889X
has issn l: 2296-889X
has NLM journal title abbreviation: Front Mol Biosci
publication name: Frontiers in molecular biosciences
language: eng
has national library of medicine journal id: 101653173
derived from: NLM
pg: 1386623
has place of publication: Switzerland
source: Front Mol Biosci. 2024;11():1386623.
volume: 11

Oleogel classification, physicochemical characterization methods, and typical cases of application in food: a review.
pmid: 38585566
abstract: The harmful effects of trans and saturated fatty acids have attracted worldwide attention. Edible oleogels, which can structure liquid oils, are promising healthy alternatives to traditional fats. Active research on oleogels is focused on the interaction between unsaturated oils with different fatty acid compositions and low molecular weight or polymer oleogels. The unique network structure inside oleogels has facilitated their application in candies, spreads, meat, and other products. However, the micro- and macro-properties, as well as the functional properties of oleogels vary by preparation method and the system composition. This review discusses the characteristics of oleogels, serving as a reference for the application of oleogels in food products. Specifically, it (i) classifies oleogels and explains the influence of gelling factors on their gelation, (ii) describes the methods for measuring the physicochemical properties of oleogels, and (iii) discusses the current applications of oleogels in food products.
rights: © The Korean Society of Food Science and Technology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 1501
doi: 10.1007/s10068-023-01501-z
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Qiu H
      type: Person
      first name: Hongtu
      last name: Qiu
      member of: Department of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, 77 Yongbong-ro Buk-gu, Gwangju, 61186 South Korea.Department of School of Life Science and Bioengineering, Jining University, No.1 Xin tan Road, JiNing, 273155 China.Yanbian University, Department of Food Science and Technology, No.977 Gong yuan Road, Yanji, 133002 China.
  slot:
    index: 2
    item: Zhang H
      type: Person
      first name: Hua
      last name: Zhang
      member of: Yanbian University, Department of Food Science and Technology, No.977 Gong yuan Road, Yanji, 133002 China.
  slot:
    index: 3
    item: Eun JB
      type: Person
      first name: Jong-Bang
      last name: Eun
      member of: Department of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, 77 Yongbong-ro Buk-gu, Gwangju, 61186 South Korea.
created: 2024-4-8T06:42
date last updated: 2025-03-09
issued: 2024-05
dp: 2024 May
created: 2024-4-8T04:32
e ISSN: 2092-6456
has issn l: 1226-7708
issue: 6
has NLM journal title abbreviation: Food Sci Biotechnol
publication name: Food science and biotechnology
language: eng
has national library of medicine journal id: 9816587
derived from: NLM
starting page: 1273
ending page: 1293
has place of publication: Korea (South)
source: Food Sci Biotechnol. 2024-05;33(6):1273-1293.
volume: 33

Role of placental membrane in ACL graft healing - A series of 18 patients.
pmid: 38586184
abstract: ACL injuries are common and the standard treatment remains to be ACL reconstruction. Controversy still remains around graft ligamentisation and various methods have been experimented to augment this process. In this series we discuss the outcome of using dehydrated umbilical cord derived membrane in ACL reconstruction.A prospective Level IV analysis of outcome in 30 consecutive patients of complete isolated ACL tear presenting to us between May 2022 to September 2022 was done. There was no age or sex restriction. Revision cases were excluded from this series. ACL reconstruction was done using standard all inside technique using the ipsilateral semitendinosus graft which was wrapped with dehydrated umbilical cord derived membrane (5*3 cm2) after soaking in normal saline (Cord Thick - Life Cell; LifeCell international private limited, Chennai, Tamil Nadu, India) and secured with Monocryl 3-0 sutures in a continuous manner.18 patients completed the one year follow up and were analysed for final results. Eleven of the patients followed up were females and seven males, with an average age of 30.3 years.The average VAS score at 6 weeks was 2.2. The mean KOOS score at the follow up visits were 72.3, 82.3, 90.7, 95.8. The mean SANE score reported at 6 weeks, 3 months, 6 months and 1 year were 68.8, 80, 87.5, 95.1.The follow up MRI's confirmed good ligamentisation of the graft even as early as 6 weeks with minimal fluid in the tunnel.The use of dehydrated umbilical cord derived membrane augmentation to potentiate graft integration in ACL reconstruction seems promising and helps improve patient outcomes.
rights: © 2024 Delhi Orthopedic Association. All rights reserved.
has PII: S0976-5662(24)00047-X
doi: 10.1016/j.jcot.2024.102378
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mukhopadhyay R
      type: Person
      first name: Reetadyuti
      last name: Mukhopadhyay
      member of: Shoulder, Arthroscopy & Sports Injuries, CK Birla Hospital, Gurgaon, India.
  slot:
    index: 2
    item: Chanda D
      type: Person
      first name: Debashish
      last name: Chanda
      member of: Knee & Joint Replacement, CK Birla Hospital, Gurgaon, India.
  slot:
    index: 3
    item: Chawla A
      type: Person
      first name: Anuj
      last name: Chawla
      member of: Foot & Ankle, CK Birla Hospital, Gurgaon, India.
  slot:
    index: 4
    item: Arora C
      type: Person
      first name: Chirag
      last name: Arora
      member of: Orthopaedics, CK Birla Hospital, Gurgaon, India.
created: 2024-4-8T06:42
date last updated: 2025-03-09
issued: 2024-03
dp: 2024 Mar
created: 2024-4-8T04:42
ISSN: 0976-5662
has issn l: 0976-5662
has NLM journal title abbreviation: J Clin Orthop Trauma
publication name: Journal of clinical orthopaedics and trauma
language: eng
has national library of medicine journal id: 101559469
derived from: NLM
pg: 102378
has place of publication: India
source: J Clin Orthop Trauma. 2024-03;50():102378.
volume: 50

Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2.
pmid: 38591877
abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide range of hosts, including hippopotami, which are semi-aquatic mammals and phylogenetically closely related to Cetacea. In this study, we characterized the binding properties of hippopotamus angiotensin-converting enzyme 2 (hiACE2) to the spike (S) protein receptor binding domains (RBDs) of the SARS-CoV-2 prototype (PT) and variants of concern (VOCs). Furthermore, the cryo-electron microscopy (cryo-EM) structure of the SARS-CoV-2 PT S protein complexed with hiACE2 was resolved. Structural and mutational analyses revealed that L30 and F83, which are specific to hiACE2, played a crucial role in the hiACE2/SARS-CoV-2 RBD interaction. In addition, comparative and structural analysis of ACE2 orthologs suggested that the cetaceans may have the potential to be infected by SARS-CoV-2. These results provide crucial molecular insights into the susceptibility of hippopotami to SARS-CoV-2 and suggest the potential risk of SARS-CoV-2 VOCs spillover and the necessity for surveillance.The hippopotami are the first semi-aquatic artiodactyl mammals wherein SARS-CoV-2 infection has been reported. Exploration of the invasion mechanism of SARS-CoV-2 will provide important information for the surveillance of SARS-CoV-2 in hippopotami, as well as other semi-aquatic mammals and cetaceans. Here, we found that hippopotamus ACE2 (hiACE2) could efficiently bind to the RBDs of the SARS-CoV-2 prototype (PT) and variants of concern (VOCs) and facilitate the transduction of SARS-CoV-2 PT and VOCs pseudoviruses into hiACE2-expressing cells. The cryo-EM structure of the SARS-CoV-2 PT S protein complexed with hiACE2 elucidated a few critical residues in the RBD/hiACE2 interface, especially L30 and F83 of hiACE2 which are unique to hiACE2 and contributed to the decreased binding affinity to PT RBD compared to human ACE2. Our work provides insight into cross-species transmission and highlights the necessity for monitoring host jump[cell cut: 2069 characters, first 2000 kept]
doi: 10.1128/jvi.00451-24
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Yang R
      type: Person
      first name: Ruirui
      last name: Yang
      member of: College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
  slot:
    index: 2
    item: Han P
      type: Person
      first name: Pu
      last name: Han
      member of: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
  slot:
    index: 3
    item: Han P
      type: Person
      first name: Pengcheng
      last name: Han
      member of: School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.
  slot:
    index: 4
    item: Li D
      type: Person
      first name: Dedong
      last name: Li
      member of: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.College of Veterinary Medicine, China Agricultural University, Beijing, China.
  slot:
    index: 5
    item: Zhao R
      type: Person
      first name: Runchu
      last name: Zhao
      member of: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.Institute of Physical Science and Information Technology, Anhui University, Hefei, China.
  slot:
    index: 6
    item: Niu S
      type: Person
      first name: Sheng
      last name: Niu
      member of: College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
  slot:
    index: 7
    item: Liu K
      type: Person
      first name: Kefang
      last name: Liu
      member of: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
  slot:
    index: 8
    item: Li S
      type: Person
      first name: Shihua
      last name: Li
      member of: CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
  slot:
    index: 9
    item: Tian W-X
      type: Person
      first name: Wen-Xia
      last name: Tian
      member of: College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
  slot:
    index: 10
    item: Gao GF
      type: Person
      first name: George Fu
      last name: Gao
      member of: College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
created: 2024-4-9T12:44
date last updated: 2025-03-09
issued: 2024-05-14
dp: 2024 May 14
created: 2024-4-9T09:02
e ISSN: 1098-5514
has issn l: 0022-538X
issue: 5
has NLM journal title abbreviation: J Virol
publication name: Journal of virology
language: eng
has national library of medicine journal id: 0113724
derived from: NLM
pg: e0045124
has place of publication: United States
has primary subject term: D000085962Q000378Q000737Q000235
has primary subject term: D001188Q000821
has primary subject term: D000086402Q000235Q000378
has primary subject term: D064370Q000378Q000737Q000235
has subject term: D000818
has subject term: D006801
has subject term: D000073640Q000235Q000378
has subject term: D001665
has subject term: D000086382Q000821Q000378
has subject term: D020285
has subject term: D011485
source: J Virol. 2024-05-14;98(5):e0045124.
volume: 98

Bioactive carbohydrate polymers from marine sources as potent nutraceuticals in modulating obesity: a review.
pmid: 38623423
abstract: The majority of bioactive polysaccharides are present in some marine creatures. These polysaccharides are considered as promising anti-obesity agents, their anti-obesity properties involve a number of mechanisms, including suppression of lipid metabolism and absorption, impact on satiety, and prevention of adipocyte differentiation. Obesity is linked to type 2 diabetes, cardiovascular disease, and other metabolic syndromes. In this review various bioactive polysaccharides like chitin, chitosan, fucosylated chondroitin sulphate, chitooligosaccharides and glycosaminoglycans have been discussed for their anti-obesity effects through various pathways. Critical evaluation of observational studies and intervention trials on obesity, lipid hypertrophy, dyslipidemia, and type 2 diabetes was done with a primary focus on specific marine fauna polysaccharide as a source of seafood that is consumed all over the world. It has been observed that consumption of individual seafood constituents was effective in reducing obesity. Thus, marine derived novel bioactive polysaccharides have potential applications in food and pharmaceutical industries.
rights: © The Korean Society of Food Science and Technology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 1525
doi: 10.1007/s10068-024-01525-z
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Geetha V
      type: Person
      first name: V
      last name: Geetha
      member of: Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru, 570020 India.Department of Biosciences, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199 India.
  slot:
    index: 2
    item: Mayookha VP
      type: Person
      first name: V P
      last name: Mayookha
      member of: Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru, 570020 India.Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India.
  slot:
    index: 3
    item: Das M
      type: Person
      first name: Moumita
      last name: Das
      member of: Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru, 570020 India.Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India.
  slot:
    index: 4
    item: Kumar GS
      type: Person
      first name: G Suresh
      last name: Kumar
      member of: Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru, 570020 India.Department of Biosciences, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199 India.Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002 India.
created: 2024-4-16T12:45
date last updated: 2025-03-09
issued: 2024-06
dp: 2024 Jun
created: 2024-4-16T03:40
e ISSN: 2092-6456
has issn l: 1226-7708
issue: 7
has NLM journal title abbreviation: Food Sci Biotechnol
publication name: Food science and biotechnology
language: eng
has national library of medicine journal id: 9816587
derived from: NLM
starting page: 1517
ending page: 1528
has place of publication: Korea (South)
source: Food Sci Biotechnol. 2024-06;33(7):1517-1528.
volume: 33

Assessment of the Impact of SARS-CoV-2 Infection on the Sexual Function of Women, Levels of Oxytocin and Prolactin: A Prospective Cohort Study.
pmid: 38673504
abstract: (1) Background: There is a lack of direct evidence on whether SARS-CoV-2 affects women's sexual function through a biological-organic mechanism. Existing studies on the topic are few and have produced contradictory results. This study aims to explore the possible relationship between sex hormones and sexual function in patients who have been infected with SARS-CoV-2. Moreover, we aimed to determine whether these changes are related to the clinical course of COVID-19 and whether they are temporary or long-lasting. (2) Methods: A study was conducted on 104 women, including 64 women infected with COVID-19 and a control group of 40 healthy women, between January 2021 and August 2022. Blood samples were collected to measure prolactin and oxytocin levels, and a clinical assessment was performed 3 and 6 months later. Sexual function self-assessment was captured based on the FSFI scale. (3) Results: Our study found that patients with severe COVID-19 had better sexual satisfaction scores one month after recovery but no discernible difference after six months. High levels of serum prolactin were observed in patients with active COVID-19 but became similar to a control group after one month and remained stable over time. Higher prolactin levels were significantly associated with increased arousal and hydration. Individuals with severe COVID-19 had notably low levels of plasma oxytocin, but there was no correlation between oxytocin levels and sexual satisfaction. (4) Conclusions: The gynecologic symptoms, as well as disturbances in oxytocin and prolactin levels, might be observed in a short time after infection. However, SARS-CoV-2 infection has no lasting effect on sexual function, oxytocin, and prolactin levels among women.
has PII: jcm13082230
doi: 10.3390/jcm13082230
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Żak K
      type: Person
      first name: Klaudia
      last name: Żak
      member of: Department of Medical Chemistry, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 2
    item: Starek E
      type: Person
      first name: Ernest
      last name: Starek
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
  slot:
    index: 3
    item: Korga-Plewko A
      type: Person
      first name: Agnieszka
      last name: Korga-Plewko
      member of: Independent Medical Biology Unit, Medical University of Lublin, 20-090 Lublin, Poland.
  slot:
    index: 4
    item: Rasoul-Pelińska K
      type: Person
      first name: Karolina
      last name: Rasoul-Pelińska
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
  slot:
    index: 5
    item: Abramiuk M
      type: Person
      first name: Monika
      last name: Abramiuk
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 6
    item: Michalczuk M
      type: Person
      first name: Mariola
      last name: Michalczuk
      member of: Independent Medical Biology Unit, Medical University of Lublin, 20-090 Lublin, Poland.
  slot:
    index: 7
    item: Rajtak A
      type: Person
      first name: Alicja
      last name: Rajtak
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
  slot:
    index: 8
    item: Kotarski J
      type: Person
      first name: Jan
      last name: Kotarski
      member of: Independent Laboratory of Cancer Diagnostics and Immunology, Medical University in Lublin, 20-081 Lublin, Poland.
  slot:
    index: 9
    item: Frankowska K
      type: Person
      first name: Karolina
      last name: Frankowska
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
  slot:
    index: 10
    item: Bis L
      type: Person
      first name: Liliana
      last name: Bis
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
  slot:
    index: 11
    item: Ostrowska-Leśko M
      type: Person
      first name: Marta
      last name: Ostrowska-Leśko
      member of: Chair and Department of Toxicology, Medical University of Lublin, 20-090 Lublin, Poland.
  slot:
    index: 12
    item: Bobiński M
      type: Person
      first name: Marcin
      last name: Bobiński
      member of: I Chair and Department of Oncologic Gynecology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
created: 2024-4-27T09:54
date last updated: 2025-03-09
issued: 2024-04-12
dp: 2024 Apr 12
created: 2024-4-27T01:11
ISSN: 2077-0383
has issn l: 2077-0383
issue: 8
has NLM journal title abbreviation: J Clin Med
publication name: Journal of clinical medicine
language: eng
has national library of medicine journal id: 101606588
derived from: NLM
has place of publication: Switzerland
source: J Clin Med. 2024-04-12;13(8):.
volume: 13

Comparison of aspiration catheter performance using adaptive pulsatile aspiration in an in vitro thrombectomy model.
pmid: 38693768
abstract: Aspiration with a pump or syringe is a mainstay of mechanical thrombectomy (MT) for acute ischemic stroke (AIS), but this technology has seen minimal evolution. Non-continuous adaptive pulsatile aspiration (APA) has been proposed as a potential alternative to standard continuous aspiration as a means of improving revascularization efficiency.Using a pathophysiological flow bench model with a synthetic clot, we performed in vitro thrombectomies using the ALGO® Von Vascular, Inc. (Sunrise, FL) APA pump. A total of 25 FDA-approved aspiration catheters were tested, representing inner diameters (ID) from 0.035 in. to 0.088 in. The pump was used in 30 trials with each catheter to remove a simulated M1 occlusion. Revascularization, clot ingestion, time to clot removal, and distal embolization were measured.Among catheters tested using APA, first-pass TICI 3 revascularization was achieved in 100% of the 750 thrombectomy trials using 25 different catheters. There were no distal emboli detected in any trial run. Complete clot ingestion into the pump collection chamber was achieved in 87% to 100% of trials (overall 95%) with clot in the remaining trials corking within the catheter and removed from the model. Time from clot contact to clot removal ranged from 11 s to 90 s (mean 22.6 s, SD 16.8 s), which was negatively correlated with catheter ID (p = 0.007).APA via the Von Vascular, Inc. ALGO® pump achieved a high success rate in an in vitro MT model. All catheters tested with the pump achieved complete reperfusion in all trials, and complete clot ingestion into the pump was seen in a majority of trials. The promising in vitro performance of APA using multiple catheters warrants future in vivo investigation.
doi: 10.1177/15910199241250082
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Silva MA
      type: Person
      first name: Michael A
      last name: Silva
      member of: Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  slot:
    index: 2
    item: Sanikommu S
      type: Person
      first name: Sai
      last name: Sanikommu
      member of: Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  slot:
    index: 3
    item: Bartkevitch Rodrigues P
      type: Person
      first name: Pedro
      last name: Bartkevitch Rodrigues
      member of: Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  slot:
    index: 4
    item: Hanser M
      type: Person
      first name: Manning
      last name: Hanser
      member of: Von Vascular Inc., Sunrise, FL, USA.
  slot:
    index: 5
    item: Ortiz R
      type: Person
      first name: Ryan
      last name: Ortiz
      member of: Von Vascular Inc., Sunrise, FL, USA.
  slot:
    index: 6
    item: Gamez V
      type: Person
      first name: Victor
      last name: Gamez
      member of: Von Vascular Inc., Sunrise, FL, USA.
  slot:
    index: 7
    item: Starke RM
      type: Person
      first name: Robert M
      last name: Starke
      member of: Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
created: 2024-5-2T06:42
date last updated: 2025-03-09
issued: 2024-05-01
dp: 2024 May 01
created: 2024-5-2T02:43
e ISSN: 2385-2011
has issn l: 1591-0199
has NLM journal title abbreviation: Interv Neuroradiol
publication name: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
language: eng
has national library of medicine journal id: 9602695
derived from: NLM
pg: 15910199241250082
has place of publication: United States
source: Interv Neuroradiol. 2024-05-01;():15910199241250082.

European Survey on Clinical Practice of Detecting and Treating T-Cell Mediated Kidney Transplant Rejection.
pmid: 38699173
abstract: The KDIGO guideline for acute rejection treatment recommends use of corticosteroids and suggests using lymphocyte-depleting agents as second line treatment. Aim of the study was to determine the current practices of detection and treatment of TCMR of kidney allografts amongst European kidney transplant centres. An invitation was sent through ESOT/EKITA newsletters and through social media to transplant professionals in Europe for taking part in the survey. A total of 129 transplant professionals responded to the survey. There was equal representation of small and large sized transplant centres. The majority of centres treat borderline changes (BL) and TCMR (Grade IA-B, IIA-B) in indication biopsies and protocol biopsies with corticosteroids as first line treatment. Thymoglobulin is used mainly as second line treatment for TCMR Grade IA-B (80%) and TCMR IIA-B (85%). Treatment success is most often evaluated within one month of therapy. There were no differences observed between the large and small centres for the management of TCMR. This survey highlights the common practices and diversity in clinics for the management of TCMR in Europe. Testing new therapies for TCMR should be in comparison to the current standard of care in Europe. Better consensus on treatment success is crucial for robust study designs.
rights: Copyright © 2024 Koshy, Furian, Nickerson, Zaza, Haller, de Vries and Naesens.
has PII: 12283
doi: 10.3389/ti.2024.12283
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Koshy P
      type: Person
      first name: Priyanka
      last name: Koshy
      member of: Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 2
    item: Furian L
      type: Person
      first name: Lucrezia
      last name: Furian
      member of: Kidney and Pancreas Transplantation Unit, Department of Surgical Gastroenterological and Oncological Sciences, University Hospital of Padua, Padua, Italy.
  slot:
    index: 3
    item: Nickerson P
      type: Person
      first name: Peter
      last name: Nickerson
      member of: Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
  slot:
    index: 4
    item: Zaza G
      type: Person
      first name: Gianluigi
      last name: Zaza
      member of: Renal, Dialysis and Transplant Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
  slot:
    index: 5
    item: Haller M
      type: Person
      first name: Maria
      last name: Haller
      member of: Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Vienna, Austria.Nephrology, Ordensklinikum Linz, Elisabethinen, Linz, Austria.
  slot:
    index: 6
    item: de Vries APJ
      type: Person
      first name: Aiko P J
      last name: de Vries
      member of: Department of Medicine, Division of Nephrology, Leiden Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
  slot:
    index: 7
    item: Naesens M
      type: Person
      first name: Maarten
      last name: Naesens
      member of: Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.Department of Nephrology and Kidney Transplantation, University Hospitals Leuven, Leuven, Belgium.
created: 2024-5-3T06:43
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-5-3T03:50
e ISSN: 1432-2277
has issn l: 0934-0874
has NLM journal title abbreviation: Transpl Int
publication name: Transplant international : official journal of the European Society for Organ Transplantation
language: eng
has national library of medicine journal id: 8908516
derived from: NLM
pg: 12283
has place of publication: Switzerland
has primary subject term: D016030
has primary subject term: D006084Q000175
has subject term: D006801
has subject term: D005060
has subject term: D011795
has subject term: D013601Q000276
has subject term: D007166Q000627
has subject term: D000305Q000627
has subject term: D001706
has subject term: D000961Q000627
source: Transpl Int. 2024;37():12283.
volume: 37

http://rdf.ncbi.nlm.nih.gov/pubmed/38706757
pmid: 38706757
abstract: Cow's milk allergy (CMA) is the most common food allergy in infants. The replacement with specialized formulas is an established clinical approach to ensure adequate growth and minimize the risk of severe allergic reactions when breastfeeding is not possible. Still, given the availability of multiple options, such as extensively hydrolyzed cow's milk protein formula (eHF-CM), amino acid formula (AAF), hydrolyzed rice formula (HRF) and soy formulas (SF), there is some uncertainty as to the most suitable choice with respect to health outcomes. Furthermore, the addition of probiotics to a formula has been proposed as a potential approach to maximize benefit.These evidence-based guidelines from the World Allergy Organization (WAO) intend to support patients, clinicians, and others in decisions about the use of milk specialized formulas, with and without probiotics, for individuals with CMA.WAO formed a multidisciplinary guideline panel balanced to include the views of all stakeholders and to minimize potential biases from competing interests. The McMaster University GRADE Centre supported the guideline-development process, including updating or performing systematic evidence reviews. The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used, including GRADE Evidence-to-Decision frameworks, which were subject to review by stakeholders.After reviewing the summarized evidence and thoroughly discussing the different management options, the WAO guideline panel suggests: a) using an extensively hydrolyzed (cow's milk) formula or a hydrolyzed rice formula as the first option for managing infants with immunoglobulin E (IgE) and non-IgE-mediated CMA who are not being breastfed. An amino-acid formula or a soy formula could be regarded as second and third options respectively; b) using either a formula without a probiotic or a casei[cell cut: 2812 characters, first 2000 kept]
rights: © 2024 The Author(s).
has PII: S1939-4551(24)00019-X
doi: 10.1016/j.waojou.2024.100888
creator: OrderedList
  length: 39
  slot:
    index: 1
    item: Bognanni A
      type: Person
      first name: Antonio
      last name: Bognanni
      member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  slot:
    index: 2
    item: Fiocchi A
      type: Person
      first name: Alessandro
      last name: Fiocchi
      member of: Translational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy.
  slot:
    index: 3
    item: Arasi S
      type: Person
      first name: Stefania
      last name: Arasi
      member of: Translational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy.
  slot:
    index: 4
    item: Chu DK
      type: Person
      first name: Derek K
      last name: Chu
      member of: Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 5
    item: Ansotegui I
      type: Person
      first name: Ignacio
      last name: Ansotegui
      member of: Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain.
  slot:
    index: 6
    item: Assa'ad AH
      type: Person
      first name: Amal H
      last name: Assa'ad
      member of: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  slot:
    index: 7
    item: Bahna SL
      type: Person
      first name: Sami L
      last name: Bahna
      member of: Allergy and Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
  slot:
    index: 8
    item: Berni Canani R
      type: Person
      first name: Roberto
      last name: Berni Canani
      member of: Pediatric Allergy Program at the Department of Translational Medical Science, and ImmunoNutritionLab at Ceinge Advanced Biotechnologies, University of Naples Federico II, Naples, Italy.
  slot:
    index: 9
    item: Bozzola M
      type: Person
      first name: Martin
      last name: Bozzola
      member of: Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.Department of Pediatrics, British Hospital-Perdriel, Buenos Aires, Argentina.
  slot:
    index: 10
    item: Dahdah L
      type: Person
      first name: Lamia
      last name: Dahdah
      member of: Translational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy.
  slot:
    index: 11
    item: Dupont C
      type: Person
      first name: Christophe
      last name: Dupont
      member of: Paris Descartes University, Pediatric Gastroenterology, Necker Hospital, Paris, France.Clinique Marcel Sembat, Boulogne-Billancourt, France.
  slot:
    index: 12
    item: Dziechciarz P
      type: Person
      first name: Piotr
      last name: Dziechciarz
      member of: Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland.
  slot:
    index: 13
    item: Ebisawa M
      type: Person
      first name: Motohiro
      last name: Ebisawa
      member of: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.
  slot:
    index: 14
    item: Firmino RT
      type: Person
      first name: Ramon T
      last name: Firmino
      member of: Faculty of Medical Sciences of Campina Grande, UNIFACISA University Centre, Campina Grande, Paraiba, Brazil.
  slot:
    index: 15
    item: Chu A
      type: Person
      first name: Alexandro
      last name: Chu
      member of: Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 16
    item: Galli E
      type: Person
      first name: Elena
      last name: Galli
      member of: Pediatric Allergy Unit, San Pietro Hospital - Fatebenefratelli, Rome, Italy.
  slot:
    index: 17
    item: Horvath A
      type: Person
      first name: Andrea
      last name: Horvath
      member of: Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland.
  slot:
    index: 18
    item: Kamenwa R
      type: Person
      first name: Rose
      last name: Kamenwa
      member of: Department of Paediatrics and Child Health, Aga Khan University Hospital, Nairobi, Kenya.
  slot:
    index: 19
    item: Lack G
      type: Person
      first name: Gideon
      last name: Lack
      member of: King's College London, Asthma-UK Centre in Allergic Mechanisms of Asthma, Department of Pediatric Allergy, St Thomas' Hospital, London, UK.
  slot:
    index: 20
    item: Li H
      type: Person
      first name: Haiqi
      last name: Li
      member of: Department of Primary Child Care, Children's Hospital, Chongqing Medical University, China.
  slot:
    index: 21
    item: Martelli A
      type: Person
      first name: Alberto
      last name: Martelli
      member of: Member of Italian Society of Allergy and Pediatric Immunology (SIAIP), Italy.
  slot:
    index: 22
    item: Nowak-Węgrzyn A
      type: Person
      first name: Anna
      last name: Nowak-Węgrzyn
      member of: Department of Pediatrics, NYU Grossman School of Medicine, Hassenfeld Children's Hospital, New York, NY, USA.Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
  slot:
    index: 23
    item: Papadopoulos NG
      type: Person
      first name: Nikolaos G
      last name: Papadopoulos
      member of: Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
  slot:
    index: 24
    item: Pawankar R
      type: Person
      first name: Ruby
      last name: Pawankar
      member of: Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
  slot:
    index: 25
    item: Roldan Y
      type: Person
      first name: Yetiani
      last name: Roldan
      member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 26
    item: Said M
      type: Person
      first name: Maria
      last name: Said
      member of: Allergy & Anaphylaxis Australia, Castle Hill, New South Wales, Australia.
  slot:
    index: 27
    item: Sánchez-Borges M
      type: Person
      first name: Mario
      last name: Sánchez-Borges
      member of: Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad and Clínica El Avila, Caracas, Venezuela.
  slot:
    index: 28
    item: Shamir R
      type: Person
      first name: Raanan
      last name: Shamir
      member of: Institute for Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
created: 2024-5-6T06:44
date last updated: 2025-03-09
issued: 2024-04
dp: 2024 Apr
created: 2024-5-6T04:01
ISSN: 1939-4551
has issn l: 1939-4551
issue: 4
has NLM journal title abbreviation: World Allergy Organ J
publication name: The World Allergy Organization journal
language: eng
has national library of medicine journal id: 101481283
derived from: NLM
pg: 100888
has place of publication: United States
source: World Allergy Organ J. 2024-04;17(4):100888.
title: World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update - XII - Recommendations on milk formula supplements with and without probiotics for infants and toddlers with CMA.
volume: 17

Melanin in Auricularia auricula: biosynthesis, production, physicochemical characterization, biological functions, and applications.
pmid: 38752125
abstract: Auricularia auricular (A. auricula), a nutritious fungus and traditional medicinal resource, is known for melanin. This review aims to summarize the research progress on melanin in A. auricula, specifically focusing on biosynthesis, fermentation production, extraction processes, physicochemical characterization, biological functions, and applications. The biosynthesis of melanin in A. auricula primarily involves the oxidative polymerization reaction of phenolic compounds. To enhance melanin production, strategies such as deep fermentation culture, selection of optimal fermentation materials, and optimization of the culture medium have been employed. Various extraction processes have been compared to determine their impact on the physicochemical properties and stability of melanin. Moreover, the antioxidant and antibiofilm activities of A. auricula melanin, as well as its potential beneficial effects on the human body through in vivo experiments, have been investigated. These findings provide valuable insights into the application of A. auricula melanin and serve as a reference for future research in this field.
rights: © The Korean Society of Food Science and Technology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 1542
doi: 10.1007/s10068-024-01542-y
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wang J
      type: Person
      first name: Jiaying
      last name: Wang
      member of: Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing, 100048 People's Republic of China.
  slot:
    index: 2
    item: Ma Z
      type: Person
      first name: Zihui
      last name: Ma
      member of: Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing, 100048 People's Republic of China.
  slot:
    index: 3
    item: Wang C
      type: Person
      first name: Chengtao
      last name: Wang
      member of: Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing, 100048 People's Republic of China.
  slot:
    index: 4
    item: Chen W
      type: Person
      first name: Wei
      last name: Chen
      member of: Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing, 100048 People's Republic of China.
created: 2024-5-16T06:42
date last updated: 2025-03-09
issued: 2024-06
dp: 2024 Jun
created: 2024-5-16T03:55
e ISSN: 2092-6456
has issn l: 1226-7708
issue: 8
has NLM journal title abbreviation: Food Sci Biotechnol
publication name: Food science and biotechnology
language: eng
has national library of medicine journal id: 9816587
derived from: NLM
starting page: 1751
ending page: 1758
has place of publication: Korea (South)
source: Food Sci Biotechnol. 2024-06;33(8):1751-1758.
volume: 33

Explainability of three-dimensional convolutional neural networks for functional magnetic resonance imaging of Alzheimer's disease classification based on gradient-weighted class activation mapping.
pmid: 38771733
abstract: Currently, numerous studies focus on employing fMRI-based deep neural networks to diagnose neurological disorders such as Alzheimer's Disease (AD), yet only a handful have provided results regarding explainability. We address this gap by applying several prevalent explainability methods such as gradient-weighted class activation mapping (Grad-CAM) to an fMRI-based 3D-VGG16 network for AD diagnosis to improve the model's explainability. The aim is to explore the specific Region of Interest (ROI) of brain the model primarily focuses on when making predictions, as well as whether there are differences in these ROIs between AD and normal controls (NCs). First, we utilized multiple resting-state functional activity maps including ALFF, fALFF, ReHo, and VMHC to reduce the complexity of fMRI data, which differed from many studies that utilized raw fMRI data. Compared to methods utilizing raw fMRI data, this manual feature extraction approach may potentially alleviate the model's burden. Subsequently, 3D-VGG16 were employed for AD classification, where the final fully connected layers were replaced with a Global Average Pooling (GAP) layer, aimed at mitigating overfitting while preserving spatial information within the feature maps. The model achieved a maximum of 96.4% accuracy on the test set. Finally, several 3D CAM methods were employed to interpret the models. In the explainability results of the models with relatively high accuracy, the highlighted ROIs were primarily located in the precuneus and the hippocampus for AD subjects, while the models focused on the entire brain for NC. This supports current research on ROIs involved in AD. We believe that explaining deep learning models would not only provide support for existing research on brain disorders, but also offer important referential recommendations for the study of currently unknown etiologies.
rights: Copyright: © 2024 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-23-40870
doi: 10.1371/journal.pone.0303278
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Song B
      type: Person
      first name: Boyue
      last name: Song
      member of: Graduate School of Engineering, Kochi University of Technology, Kami City, Kochi Prefecture, Japan.
  slot:
    index: 2
    item: Yoshida S
      type: Person
      first name: Shinichi
      last name: Yoshida
      member of: School of Information, Kochi University of Technology, Kami City, Kochi Prefecture, Japan.
creator: Alzheimer’s Disease Neuroimaging Initiative
created: 2024-5-21T18:44
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-5-21T13:23
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 5
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0303278
has place of publication: United States
has primary subject term: D000544Q000000981Q000145Q000503
has primary subject term: D008279Q000379
has primary subject term: D016571
has primary subject term: D001931Q000379
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000368
has subject term: D001921Q000000981Q000503
source: PLoS One. 2024;19(5):e0303278.
volume: 19

Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust.
pmid: 38771937
abstract: Uranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been described; however, transcriptomic changes within the intestinal epithelial cells and impacts on lineage differentiation are largely unknown.Herein, we sought to determine the molecular and cellular changes that occur in the colon in response to uranium bearing dust (UBD) exposure.Human colonoids from three biologically distinct donors were acutely exposed to UBD then digested for single cell RNA sequencing to define the molecular changes that occur to specific identities of colonic epithelial cells. Validation in colonoids was assessed using morphological and imaging techniques.Human colonoids acutely exposed to UBD exhibited disrupted proliferation and hyperplastic differentiation of the secretory lineage cell, enteroendocrine cells (EEC). Single-cell RNA sequencing also showed more EEC subtypes present in UBD-exposed colonoids.These findings highlight the significance of crypt-based proliferative cells and secretory cell differentiation using human colonoids to model major colonic responses to uranium-bearing particulate dust exposure. https://doi.org/10.1289/EHP13855.
doi: 10.1289/EHP13855
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Atanga R
      type: Person
      first name: Roger
      last name: Atanga
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  slot:
    index: 2
    item: Appell LL
      type: Person
      first name: Lidia L
      last name: Appell
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  slot:
    index: 3
    item: Thompson MN
      type: Person
      first name: Myranda N
      last name: Thompson
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  slot:
    index: 4
    item: Lauer FT
      type: Person
      first name: Fredine T
      last name: Lauer
      member of: Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  slot:
    index: 5
    item: Brearley A
      type: Person
      first name: Adrian
      last name: Brearley
      member of: Department of Earth and Planetary Sciences, College of Arts and Sciences, University of New Mexico, Albuquerque, New Mexico, USA.
  slot:
    index: 6
    item: Campen MJ
      type: Person
      first name: Matthew J
      last name: Campen
      member of: Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  slot:
    index: 7
    item: Castillo EF
      type: Person
      first name: Eliseo F
      last name: Castillo
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  slot:
    index: 8
    item: In JG
      type: Person
      first name: Julie G
      last name: In
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
created: 2024-5-21T18:43
date last updated: 2025-03-09
issued: 2024-05
dp: 2024 May
created: 2024-5-21T14:23
e ISSN: 1552-9924
has issn l: 0091-6765
issue: 5
has NLM journal title abbreviation: Environ Health Perspect
publication name: Environmental health perspectives
language: eng
has national library of medicine journal id: 0330411
derived from: NLM
pg: 57006
has place of publication: United States
has primary subject term: D014501Q000633
has primary subject term: D004391
has primary subject term: D059010
has primary subject term: D003106Q000187
has subject term: D006801
has subject term: D004847Q000187
source: Environ Health Perspect. 2024-05;132(5):57006.
volume: 132

Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task.
pmid: 38774430
abstract: The Probabilistic Reward Task (PRT) is widely used to investigate the impact of Major Depressive Disorder (MDD) on reinforcement learning (RL), and recent studies have used it to provide insight into decision-making mechanisms affected by MDD. The current project used PRT data from unmedicated, treatment-seeking adults with MDD to extend these efforts by: (1) providing a more detailed analysis of standard PRT metrics-response bias and discriminability-to better understand how the task is performed; (2) analyzing the data with two computational models and providing psychometric analyses of both; and (3) determining whether response bias, discriminability, or model parameters predicted responses to treatment with placebo or the atypical antidepressant bupropion. Analysis of standard metrics replicated recent work by demonstrating a dependency between response bias and response time (RT), and by showing that reward totals in the PRT are governed by discriminability. Behavior was well-captured by the Hierarchical Drift Diffusion Model (HDDM), which models decision-making processes; the HDDM showed excellent internal consistency and acceptable retest reliability. A separate belief model reproduced the evolution of response bias over time better than the HDDM, but its psychometric properties were weaker. Finally, the predictive utility of the PRT was limited by small samples; nevertheless, depressed adults who responded to bupropion showed larger pre-treatment starting point biases in the HDDM than non-responders, indicating greater sensitivity to the PRT's asymmetric reinforcement contingencies. Together, these findings enhance our understanding of reward and decision-making mechanisms that are implicated in MDD and probed by the PRT.
rights: Copyright: © 2024 The Author(s).
doi: 10.5334/cpsy.108
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Dillon DG
      type: Person
      first name: Daniel G
      last name: Dillon
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.Harvard Medical School, Boston MA, USA.
  slot:
    index: 2
    item: Belleau EL
      type: Person
      first name: Emily L
      last name: Belleau
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.Harvard Medical School, Boston MA, USA.
  slot:
    index: 3
    item: Origlio J
      type: Person
      first name: Julianne
      last name: Origlio
      member of: Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 4
    item: McKee M
      type: Person
      first name: Madison
      last name: McKee
      member of: Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 5
    item: Jahan A
      type: Person
      first name: Aava
      last name: Jahan
      member of: Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 6
    item: Meyer A
      type: Person
      first name: Ashley
      last name: Meyer
      member of: Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 7
    item: Souther MK
      type: Person
      first name: Min Kang
      last name: Souther
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.
  slot:
    index: 8
    item: Brunner D
      type: Person
      first name: Devon
      last name: Brunner
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.
  slot:
    index: 9
    item: Kuhn M
      type: Person
      first name: Manuel
      last name: Kuhn
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 10
    item: Ang YS
      type: Person
      first name: Yuen Siang
      last name: Ang
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.
  slot:
    index: 11
    item: Cusin C
      type: Person
      first name: Cristina
      last name: Cusin
      member of: Harvard Medical School, Boston MA, USA.Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 12
    item: Fava M
      type: Person
      first name: Maurizio
      last name: Fava
      member of: Harvard Medical School, Boston MA, USA.Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
  slot:
    index: 13
    item: Pizzagalli DA
      type: Person
      first name: Diego A
      last name: Pizzagalli
      member of: Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA.Depression Clinical and Research Program, Massachusetts General Hospital, Boston MA, USA.
created: 2024-5-22T06:42
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-5-22T03:42
e ISSN: 2379-6227
has issn l: 2379-6227
issue: 1
has NLM journal title abbreviation: Comput Psychiatr
publication name: Computational psychiatry (Cambridge, Mass.)
language: eng
has national library of medicine journal id: 101719151
derived from: NLM
starting page: 46
ending page: 69
has place of publication: England
source: Comput Psychiatr. 2024;8(1):46-69.
volume: 8

Inferring Trajectories of Psychotic Disorders Using Dynamic Causal Modeling.
pmid: 38774642
abstract: Illness course plays a crucial role in delineating psychiatric disorders. However, existing nosologies consider only its most basic features (e.g., symptom sequence, duration). We developed a Dynamic Causal Model (DCM) that characterizes course patterns more fully using dense timeseries data. This foundational study introduces the new modeling approach and evaluates its validity using empirical and simulated data.A three-level DCM was constructed to model how latent dynamics produce symptoms of depression, mania, and psychosis. This model was fit to symptom scores of nine patients collected prospectively over four years, following first hospitalization. Simulated subjects based on these empirical data were used to evaluate model parameters at the subject-level. At the group-level, we tested the accuracy with which the DCM can estimate the latent course patterns using Parametric Empirical Bayes (PEB) and leave-one-out cross-validation.Analyses of empirical data showed that DCM accurately captured symptom trajectories for all nine subjects. Simulation results showed that parameters could be estimated accurately (correlations between generative and estimated parameters >= 0.76). Moreover, the model could distinguish different latent course patterns, with PEB correctly assigning simulated patients for eight of nine course patterns. When testing any pair of two specific course patterns using leave-one-out cross-validation, 30 out of 36 pairs showed a moderate or high out-of-samples correlation between the true group-membership and the estimated group-membership values.DCM has been widely used in neuroscience to infer latent neuronal processes from neuroimaging data. Our findings highlight the potential of adopting this methodology for modeling symptom trajectories to explicate nosologic entities, temporal patterns that define them, and facilitate personalized treatment.
rights: Copyright: © 2023 The Author(s).
doi: 10.5334/cpsy.94
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Jin J
      type: Person
      first name: Jingwen
      last name: Jin
      member of: Department of Psychology, The University of Hong Kong, Hong Kong SAR, China.State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China.
  slot:
    index: 2
    item: Zeidman P
      type: Person
      first name: Peter
      last name: Zeidman
      member of: Wellcome Centre for Human Neuroimaging, University College London, UK.
  slot:
    index: 3
    item: Friston KJ
      type: Person
      first name: Karl J
      last name: Friston
      member of: Wellcome Centre for Human Neuroimaging, University College London, UK.
  slot:
    index: 4
    item: Kotov R
      type: Person
      first name: Roman
      last name: Kotov
      member of: Department of Psychiatry, Renaissance School of Medicine, Stony Brook University, USA.
created: 2024-5-22T06:42
date last updated: 2025-03-09
issued: 2023
dp: 2023
created: 2024-5-22T03:48
e ISSN: 2379-6227
has issn l: 2379-6227
issue: 1
has NLM journal title abbreviation: Comput Psychiatr
publication name: Computational psychiatry (Cambridge, Mass.)
language: eng
has national library of medicine journal id: 101719151
derived from: NLM
starting page: 60
ending page: 75
has place of publication: England
source: Comput Psychiatr. 2023;7(1):60-75.
volume: 7

Herpes virus entry mediator signaling blockade produces mortality in neonatal sepsis through induced cardiac dysfunction.
pmid: 38774873
abstract: Sepsis remains a major source of morbidity and mortality in neonates, and characterization of immune regulation in the neonatal septic response remains limited. HVEM is a checkpoint regulator which can both stimulate or inhibit immune responses and demonstrates altered expression after sepsis. We hypothesized that signaling via HVEM would be essential for the neonatal response to sepsis, and that therefore blockade of this pathway would improve survival to septic challenge.To explore this, neonatal mice were treated with cecal slurry (CS), CS with Anti-HVEM antibody (CS-Ab) or CS with isotype (CS-IT) and followed for 7-day survival. Mice from all treatment groups had thymus, lung, kidney and peritoneal fluid harvested, weighed, and stained for histologic evaluation, and changes in cardiac function were assessed with echocardiography.Mortality was significantly higher for CS-Ab mice (72.2%) than for CS-IT mice (22.2%). CS resulted in dysregulated alveolar remodeling, but CS-Ab lungs demonstrated significantly less dysfunctional alveolar remodeling than CS alone (MCL 121.0 CS vs. 87.6 CS-Ab), as well as increased renal tubular vacuolization. No morphologic differences in alveolar septation or thymic karyorrhexis were found between CS-Ab and CS-IT. CS-Ab pups exhibited a marked decrease in heart rate (390.3 Sh vs. 342.1 CS-Ab), stroke volume (13.08 CS-IT vs. 8.83 CS-Ab) and ultimately cardiac output (4.90 Sh vs. 3.02 CS-Ab) as well as a significant increase in ejection fraction (73.74 Sh vs. 83.75 CS-Ab) and cardiac strain (40.74 Sh vs. 51.16 CS-Ab) as compared to CS-IT or Sham animals.While receptor ligation of aspects of HVEM signaling, via antibody blockade, appears to mitigate aspects of lung injury and thymic involution, stimulatory signaling via HVEM still seems to be necessary for vascular and hemodynamic resilience and overall neonatal mouse survival in response to this experimental polymicrobial septic insult. This dissonance in the activity of anti-HVEM neutr[cell cut: 2160 characters, first 2000 kept]
rights: Copyright © 2024 Wakeley, Denning, Jiang, De Paepe, Chung, Wang and Ayala.
doi: 10.3389/fimmu.2024.1365174
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Wakeley ME
      type: Person
      first name: Michelle E
      last name: Wakeley
      member of: Division of Surgical Research, Department of Surgery, Brown University, Rhode Island Hospital, Providence, RI, United States.
  slot:
    index: 2
    item: Denning NL
      type: Person
      first name: Naomi-Liza
      last name: Denning
      member of: Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.
  slot:
    index: 3
    item: Jiang J
      type: Person
      first name: Jihong
      last name: Jiang
      member of: Division of Surgical Research, Department of Surgery, Brown University, Rhode Island Hospital, Providence, RI, United States.Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 4
    item: De Paepe ME
      type: Person
      first name: Monique E
      last name: De Paepe
      member of: Department of Pathology, Women and Infants Hospital, Providence, RI, United States.
  slot:
    index: 5
    item: Chung CS
      type: Person
      first name: Chun-Shiang
      last name: Chung
      member of: Division of Surgical Research, Department of Surgery, Brown University, Rhode Island Hospital, Providence, RI, United States.
  slot:
    index: 6
    item: Wang P
      type: Person
      first name: Ping
      last name: Wang
      member of: Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.
  slot:
    index: 7
    item: Ayala A
      type: Person
      first name: Alfred
      last name: Ayala
      member of: Division of Surgical Research, Department of Surgery, Brown University, Rhode Island Hospital, Providence, RI, United States.
created: 2024-5-22T06:42
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-5-22T03:52
e ISSN: 1664-3224
has issn l: 1664-3224
has NLM journal title abbreviation: Front Immunol
publication name: Frontiers in immunology
language: eng
has national library of medicine journal id: 101560960
derived from: NLM
pg: 1365174
has place of publication: Switzerland
has primary subject term: D000831
has primary subject term: D015398
has primary subject term: D000071074Q000276Q000401
has subject term: D000818
has subject term: D051379
has subject term: D053240Q000378Q000276
has subject term: D004195
has subject term: D005260
has subject term: D006331Q000209Q000276
has subject term: D008168Q000276Q000473
has subject term: D018805Q000276Q000378
source: Front Immunol. 2024;15():1365174.
volume: 15

Marine-Derived Sulfated Glycans Inhibit the Interaction of Heparin with Adhesion Proteins of Mycoplasma pneumoniae.
pmid: 38786623
abstract: Mycoplasma pneumoniae, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate, is critical in facilitating pathogen-host interactions, presenting a strategic target for therapeutic intervention. In this study, we assembled a glycan library comprising heparin, its oligosaccharide derivatives, and a variety of marine-derived sulfated glycans to screen the potential inhibitors for the pathogen-host interactions. By using Surface Plasmon Resonance spectroscopy, we evaluated the library's efficacy in inhibiting the interaction between M. pneumoniae adhesion proteins and heparin. Our findings offer a promising avenue for developing novel therapeutic strategies against M. pneumoniae infections.
has PII: md22050232
doi: 10.3390/md22050232
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Yang J
      type: Person
      first name: Jiyuan
      last name: Yang
      member of: The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 2
    item: Song Y
      type: Person
      first name: Yuefan
      last name: Song
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 3
    item: Xia K
      type: Person
      first name: Ke
      last name: Xia
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 4
    item: Pomin VH
      type: Person
      first name: Vitor H
      last name: Pomin
      member of: Department of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, The University of Mississippi, Oxford, MS 38677, USA.
  slot:
    index: 5
    item: Wang C
      type: Person
      first name: Chunyu
      last name: Wang
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 6
    item: Qiao M
      type: Person
      first name: Mingqiang
      last name: Qiao
      member of: The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.
  slot:
    index: 7
    item: Linhardt RJ
      type: Person
      first name: Robert J
      last name: Linhardt
      member of: Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 8
    item: Dordick JS
      type: Person
      first name: Jonathan S
      last name: Dordick
      member of: Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  slot:
    index: 9
    item: Zhang F
      type: Person
      first name: Fuming
      last name: Zhang
      member of: Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
created: 2024-5-24T12:44
date last updated: 2025-03-09
issued: 2024-05-20
dp: 2024 May 20
created: 2024-5-24T09:23
e ISSN: 1660-3397
has issn l: 1660-3397
issue: 5
has NLM journal title abbreviation: Mar Drugs
publication name: Marine drugs
language: eng
has national library of medicine journal id: 101213729
derived from: NLM
has place of publication: Switzerland
has primary subject term: D006493Q000494Q000737
has primary subject term: D009177Q000187
has primary subject term: D011134Q000494Q000737
has subject term: D000818
has subject term: D018829Q000378Q000187
has subject term: D000900Q000494Q000737
has subject term: D059001
has subject term: D001422Q000187
has subject term: D054884
has subject term: D011019Q000188Q000382
has subject term: D013431Q000737Q000494
source: Mar Drugs. 2024-05-20;22(5):.
volume: 22

[Explorations about the correlation between biological changes of meninges in periodontitis mice and cognitive impairment via single-cell RNA sequencing].
pmid: 38808420
abstract: Objective: To clarify the potential correlation between biological changes of meninges in periodontitis mice and cognitive impairment by analyzing the biological changes of meninges in periodontitis mice using single-cell RNA sequencing. Methods: Thirty C57BL/6 mice were divided into two groups by using random number table method (15 mice in each group). Mice in the control group were locally administered 2% carboxyl methyl cellulose (CMC) without Porphyromonas gingivalis (Pg) on both buccal sides. A mixture of Pg W83 and 2% CMC was applied on both buccal sides in the experimental group mice three times a week, lasting for 16 weeks in total. The absorption of alveolar bone, locomotor activity and cognitive function, the activation of microglia and astrocytes in the cortex were observed and assessed. The mRNA expression levels of Occludin in meninges and brain were detected in two groups. Single-cell RNA sequencing data of meninges were processed by uniform manifold approximation and projection (UMAP). Differential genes expressions of endothelial cells were processed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. In addition, real-time fluorescence quantitative PCR (RT-qPCR) was used to verify the expressions of transcription activating factor 3 (Atf3) and apolpoprotein L domain-containing 1 (Apold 1). Results: Methylene blue staining found the distances of buccal and palatal cement-enamel junction-alveolar bone crest in experimental mice [(185.60±17.60), (206.90±13.37) μm] increased significantly compared with the control group [(135.33±9.57), (163.05±14.98) μm] (t=5.02, P=0.002; t=4.37, P=0.005). Open field experiment showed the total distance and average speed of mice in the experimental group [(971.88±164.57) cm, (3.25±0.55) cm/s] were not statistically significant compared with the control group [(914.24±278.81) cm, (3.05±0.93) cm/s] (t=0.65, P=0.525; t=0.65, P=0.520). The recognition index of the experimental grou[cell cut: 4029 characters, first 2000 kept]
doi: 10.3760/cma.j.cn112144-20231102-00234
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Jiang YT
      type: Person
      first name: Y T
      last name: Jiang
      member of: Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 2
    item: Xu LN
      type: Person
      first name: L N
      last name: Xu
      member of: Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 3
    item: Zhao XR
      type: Person
      first name: X R
      last name: Zhao
      member of: Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 4
    item: Shen H
      type: Person
      first name: H
      last name: Shen
      member of: Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 5
    item: Qiu C
      type: Person
      first name: C
      last name: Qiu
      member of: Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 6
    item: He ZY
      type: Person
      first name: Z Y
      last name: He
      member of: Laboratory of Oral Microbiota and Systemic Disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 7
    item: Zhou W
      type: Person
      first name: W
      last name: Zhou
      member of: Laboratory of Oral Microbiota and Systemic Disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
  slot:
    index: 8
    item: Song ZC
      type: Person
      first name: Z C
      last name: Song
      member of: Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China.
created: 2024-5-29T06:42
date last updated: 2025-03-08
issued: 2024-06-09
dp: 2024 Jun 09
created: 2024-5-29T04:19
ISSN: 1002-0098
has issn l: 1002-0098
issue: 6
has NLM journal title abbreviation: Zhonghua Kou Qiang Yi Xue Za Zhi
publication name: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
language: chi
has national library of medicine journal id: 8711066
rights holder: 目的： 运用单细胞转录组测序分析牙周炎小鼠脑膜的生物学改变，探讨牙周炎小鼠脑膜生物学改变与认知障碍的相关性。 方法： 将30只C57BL/6小鼠按随机数字表法随机分为2组（每组15只），在对照组小鼠上颌双颊侧局部涂抹不含牙龈卟啉单胞菌（Pg）的2%羧甲基纤维素（CMC），在实验组小鼠上颌双颊侧局部涂抹Pg W83和2%CMC的混合物，3次/周，持续16周。观察对照组和实验组小鼠上颌牙槽骨吸收情况、自主活动能力与认知功能的变化、大脑皮层中小胶质细胞和星形胶质细胞激活情况、检测小鼠脑膜和大脑内紧密连接蛋白Occludin mRNA表达情况。然后使用统一流形逼近与投影（UMAP）算法对单细胞转录组各细胞亚群数据进行降维整合处理。对内皮细胞差异基因进行基因本体（GO）和京都基因和基因组数据库（KEGG）富集分析，进一步采用实时荧光定量PCR（RT-qPCR）验证差异基因转录激活因子3（Atf3）、含载脂蛋白L域1（Apold1）的表达情况。 结果： 亚甲蓝染色实验显示，实验组小鼠上颌颊、腭侧釉质牙骨质界到牙槽嵴顶的距离［分别为（185.60±17.60）、（206.90±13.37）μm］均显著大于对照组［分别为（135.33±9.57）、（163.05±14.98）μm］（t=5.02，P=0.002；t=4.37，P=0.005）。旷场实验显示实验组小鼠的总路程和平均速度［（971.88±164.57）cm和（3.25±0.55）cm/s］与对照组［（914.24±278.81）cm和（3.05±0.93）cm/s］相比差异均无统计学意义（t=0.65，P=0.525；t=0.65，P=0.520）。新物体识别实验中实验组小鼠相对辨别指数［（48.02±16.92）%］显著低于对照组［（66.27±17.90）%］（t=2.40，P=0.027）。Y迷宫实验显示，实验组小鼠的自发交替率［（50.99±14.17）%］显著低于对照组［（63.56±11.88）%］（t=2.33，P=0.030）。免疫组化染色结果显示，实验组小鼠脑内小胶质细胞和星形胶质细胞被激活。RT-qPCR结果显示，实验组小鼠脑膜和大脑中紧密连接蛋白Occludin mRNA的表达（分别为0.61±0.10、0.64±0.20）均显著低于对照组（分别为1.02±0.25、1.04±0.31）（t=3.47，P=0.010；t=2.66，P=0.024）。单细胞转录组测序显示，脑膜存在11种细胞类型，包括内皮细胞、成纤维细胞、免疫细胞等，其中内皮细胞占比最大［对照组为26.47%（1 589/6 004），实验组为26.26%（807/3 073）］，是脑膜中最主要的细胞类型；实验组小鼠脑膜组织中粒细胞比例［11.65%（358/3 073）］较对照组［5.56%（334/6 004）］增加。进一步聚类分析内皮细胞，GO富集分析显示差异基因与血管生成、细胞黏附、细胞凋亡等有关；KEGG分析显示差异基因与白细胞介素-17信号通路、松弛素信号通路等相关。RT-qPCR显示，实验组小鼠脑膜组织中Atf3和Apold1 mRNA表达（分别为0.42±0.24、0.54±0.27）均显著低于对照组（分别为1.03±0.26、1.02±0.23）（t=3.88，P=0.005；t=3.02，P=0.017）。 结论： Pg W83慢性感染的牙周炎小鼠认知能力下降，存在神经炎症，屏障功能改变；单细胞转录组测序发现脑膜组织存在免疫细胞浸润，Atf3和Apold1基因表达下调，提示脑膜免疫和屏障功能的改变在牙周炎导致的认知障碍中发挥作用。.
derived from: NLM
starting page: 595
ending page: 603
has place of publication: China
has primary subject term: D008578Q000382Q000502
has primary subject term: D010518Q000150Q000378Q000382
has primary subject term: D060825Q000209Q000378Q000382
has subject term: D017423
has subject term: D000818
has subject term: D051379
has subject term: D008810
has subject term: D016966
has subject term: D012333
has subject term: D062793Q000235Q000378
has subject term: D023421
has subject term: D011897
source: Zhonghua Kou Qiang Yi Xue Za Zhi. 2024-06-09;59(6):595-603.
volume: 59

Association of enlarged extra-axial spaces and subdural hemorrhage in preterm infants at term-equivalent age.
pmid: 38833078
abstract: To determine the incidence of enlarged extra-axial space (EES) and its association with subdural hemorrhage (SDH) in a regional cohort of preterm infants. As part of a prospective cohort study of 395 preterm infants, brain magnetic resonance imaging (MRI) was collected on each infant at term-equivalent age. Six preterm infants showed evidence of SDH. We reviewed the MRIs to identify the incidence of EES in these 6 infants and the cohort broadly. We then completed a retrospective chart review of the 6 infants to identify any concerns for non-accidental trauma (NAT) since the MRI was obtained. The incidence of SDH in the cohort was 1.6%. The incidence of EES was 48.1% including all 6 infants with SDH. The incidence of SDH in infants with EES was 3.2%. The retrospective chart review of the 6 infants did not yield any evidence of NAT. The incidence of EES and SDH in our cohort was significantly higher than similar cohorts of term infants, demonstrating an increased risk in preterm infants. The incidence of SDH in infants with EES was greater than in the total cohort, suggesting that it is a risk factor for asymptomatic SDH in preterm infants.
rights: © 2024. The Author(s), under exclusive licence to American Society of Emergency Radiology (ASER).
has PII: 10.1007/s10140-024-02250-0
doi: 10.1007/s10140-024-02250-0
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Sharma P
      type: Person
      first name: Puneet
      last name: Sharma
      member of: Division of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue | Enders 961, Boston, 02115, MA, United States. puneet.sharma@childrens.harvard.edu.Neurodevelopmental Disorders Prevention Center, The Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, United States. puneet.sharma@childrens.harvard.edu.
  slot:
    index: 2
    item: Kline-Fath BM
      type: Person
      first name: Beth M
      last name: Kline-Fath
      member of: Neurodevelopmental Disorders Prevention Center, The Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States.Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, United States.
  slot:
    index: 3
    item: Mukthapuram S
      type: Person
      first name: Shanmukha
      last name: Mukthapuram
      member of: Neurodevelopmental Disorders Prevention Center, The Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States.Envision Physician Services, Wellington Regional Medical Center, Wellington, United States.
  slot:
    index: 4
    item: Shapiro RA
      type: Person
      first name: Robert A
      last name: Shapiro
      member of: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States.Mayerson Center for Safe and Healthy Children, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
  slot:
    index: 5
    item: Parikh NA
      type: Person
      first name: Nehal A
      last name: Parikh
      member of: Neurodevelopmental Disorders Prevention Center, The Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States.
created: 2024-6-4T12:42
date last updated: 2025-03-09
issued: 2024-08
dp: 2024 Aug
created: 2024-6-4T11:12
e ISSN: 1438-1435
has issn l: 1070-3004
issue: 4
has NLM journal title abbreviation: Emerg Radiol
publication name: Emergency radiology
language: eng
has national library of medicine journal id: 9431227
derived from: NLM
starting page: 619
ending page: 623
has place of publication: United States
has primary subject term: D008279
has primary subject term: D007234
has primary subject term: D006408Q000000981
has subject term: D006801
has subject term: D007231
has subject term: D008297
has subject term: D005260
has subject term: D012189
has subject term: D015994
has subject term: D011446
has subject term: D012307
has subject term: D007235Q000000981
source: Emerg Radiol. 2024-08;31(4):619-623.
volume: 31

Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration.
pmid: 38871216
abstract: Ocular surface hydration is critical for eye health and its impairment can lead to dry eye disease. Extracellular calcium-sensing receptor (CaSR) is regulator of ion transport in epithelial cells expressing cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. CFTR is also a major ion channel in ocular surface epithelia, however the roles of CaSR in ocular surface are not well studied. This study aims to investigate expression and functional roles of CaSR in ocular surface.CaSR immunostaining was performed in mouse and human cornea and conjunctiva. Ocular surface potential difference (OSPD) and tear fluid volume measurements were performed in mice with topically applied cinacalcet (CaSR activator) and NPS-2143 (CaSR inhibitor).CaSR is expressed in corneal and conjunctival epithelia of mice and humans. Topically administered CaSR activator cinacalcet inhibits cAMP agonist forskolin-induced Cl- secretion and CFTR activity up to 90 %. CaSR inhibitor NPS-2143 stimulates CFTR-mediated Cl- secretion in mouse ocular surface, after which cAMP agonist forskolin had minimal additional secretory effects. Single dose NPS-2143 treatment (as an eye drop) increases tear fluid volume in mice by ∼60 % compared to vehicle treatment. NPS-2143 effect on tear volume lasts at least 8 h after single dose.CaSR is a key regulator of ocular surface ion transport and CaSR inhibition promotes Cl- and tear secretion in the ocular surface. If they are found to be effective in in dry eye models, CaSR inhibitors (currently in clinical development) can potentially be repurposed as novel prosecretory treatments for dry eye disease.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S1542-0124(24)00065-X
doi: 10.1016/j.jtos.2024.06.002
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Pasricha ND
      type: Person
      first name: Neel D
      last name: Pasricha
      member of: Department of Ophthalmology, University of California, San Francisco, United States; Francis I. Proctor Foundation, University of California, San Francisco, United States.
  slot:
    index: 2
    item: Lindgren ES
      type: Person
      first name: Ethan S
      last name: Lindgren
      member of: Department of Ophthalmology, University of California, San Francisco, United States.
  slot:
    index: 3
    item: Yan R
      type: Person
      first name: Rongshan
      last name: Yan
      member of: Department of Ophthalmology, University of California, San Francisco, United States.
  slot:
    index: 4
    item: Kuo YM
      type: Person
      first name: Yien-Ming
      last name: Kuo
      member of: Department of Ophthalmology, University of California, San Francisco, United States.
  slot:
    index: 5
    item: Chan M
      type: Person
      first name: Matilda
      last name: Chan
      member of: Department of Ophthalmology, University of California, San Francisco, United States; Francis I. Proctor Foundation, University of California, San Francisco, United States.
  slot:
    index: 6
    item: Verkman AS
      type: Person
      first name: Alan S
      last name: Verkman
      member of: Department of Medicine and Physiology, University of California, San Francisco, United States.
  slot:
    index: 7
    item: Chu T
      type: Person
      first name: Tifany
      last name: Chu
      member of: Department of Pediatrics, University of California, San Francisco, United States.
  slot:
    index: 8
    item: Yottasan P
      type: Person
      first name: Pattareeya
      last name: Yottasan
      member of: Department of Pediatrics, University of California, San Francisco, United States.
  slot:
    index: 9
    item: de Souza Goncalves L
      type: Person
      first name: Livia
      last name: de Souza Goncalves
      member of: Department of Pediatrics, University of California, San Francisco, United States.
  slot:
    index: 10
    item: Cil O
      type: Person
      first name: Onur
      last name: Cil
      member of: Department of Pediatrics, University of California, San Francisco, United States. Electronic address: onur.cil@ucsf.edu.
created: 2024-6-14T00:42
date last updated: 2025-03-09
issued: 2024-10
dp: 2024 Oct
created: 2024-6-13T19:28
e ISSN: 1937-5913
has issn l: 1542-0124
has NLM journal title abbreviation: Ocul Surf
publication name: The ocular surface
language: eng
has national library of medicine journal id: 101156063
derived from: NLM
starting page: 30
ending page: 37
has place of publication: United States
has primary subject term: D044169Q000378Q000037
has primary subject term: D003228Q000378Q000187
has primary subject term: D013666Q000378
has subject term: D000818
has subject term: D051379
has subject term: D006801
has subject term: D015352Q000378Q000188
has subject term: D000069449Q000494
has subject term: D002712Q000378
has subject term: D019005Q000378Q000037
has subject term: D008810
has subject term: D003315Q000378Q000187
has subject term: D017136Q000187
has subject term: D008297
has subject term: D005260
has subject term: D009281
source: Ocul Surf. 2024-10;34():30-37.
volume: 34

A cell culture system for RPE hypoxia, a physiologic stressor relevant to AMD deposit formation.
pmid: 38871935
has PII: 10.1038/s41433-024-03166-2
doi: 10.1038/s41433-024-03166-2
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Curcio CA
      type: Person
      first name: Christine A
      last name: Curcio
      member of: Department of Ophthalmology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. cacurcio@gmail.com.
  slot:
    index: 2
    item: Goerdt L
      type: Person
      first name: Lukas
      last name: Goerdt
      member of: Department of Ophthalmology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.Department of Ophthalmology, University of Bonn, Bonn, Germany.
created: 2024-6-14T00:42
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-6-13T23:26
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 611
ending page: 612
has place of publication: England
source: Eye (Lond). 2025-03;39(4):611-612.
volume: 39

Characterizing the Communication Networks of Spanish- and English-Speaking Latinx Sexual Minority Men and Their Roles in Pre-Exposure Prophylaxis Uptake.
pmid: 38872332
abstract: While pre-exposure prophylaxis (PrEP) has demonstrated efficacy in preventing HIV transmission, disparities in access persist in the United States, especially among Hispanic/Latinx sexual minority men (SMM). Language barriers and differences in how Latinx SMM obtain information may impact access to PrEP and HIV prevention. This study used data from the 2021 American Men's Internet Survey (AMIS) to examine differences in communication networks and PrEP use among Latinx SMM by primary language (Spanish vs. English). We examined the associations between Latinx SMM's individual- and meso-level communication networks and PrEP-related outcomes using modified Poisson regression with robust variances. Spanish-speaking Latinx SMM in the study were less likely to test for HIV, be aware of PrEP, and use daily PrEP, compared to English-speaking participants. Sexuality disclosure to a healthcare provider was positively associated with PrEP uptake among all participants and predicted STI testing over the past 12 months among English-speaking Latinx SMM. Findings highlight disparities in PrEP awareness and uptake among Latinx SMM, especially among those whose primary language is Spanish. Addressing these disparities through targeted interventions, including improved communication with healthcare providers, may help facilitate PrEP access and use in this population.
doi: 10.1080/10810730.2024.2366498
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Lee JJ
      type: Person
      first name: Jane J
      last name: Lee
      member of: School of Social Work, University of Washington, Seattle, Washington, USA.
  slot:
    index: 2
    item: Wang L
      type: Person
      first name: Liying
      last name: Wang
      member of: Department of Psychology, University of Washington, Seattle, Washington, USA.
  slot:
    index: 3
    item: Vo K
      type: Person
      first name: Katie
      last name: Vo
      member of: School of Public Health, University of Washington, Seattle, Washington, USA.
  slot:
    index: 4
    item: Gonzalez C
      type: Person
      first name: Carmen
      last name: Gonzalez
      member of: Department of Communication, University of Washington, Seattle, Washington, USA.
  slot:
    index: 5
    item: Orellana ER
      type: Person
      first name: E Roberto
      last name: Orellana
      member of: School of Social Work, University of Washington, Seattle, Washington, USA.
  slot:
    index: 6
    item: Kerani RP
      type: Person
      first name: Roxanne P
      last name: Kerani
      member of: Department of Medicine, University of Washington, Seattle, Washington, USA.
  slot:
    index: 7
    item: Katz DA
      type: Person
      first name: David A
      last name: Katz
      member of: Department of Global Health, University of Washington, Seattle, Washington, USA.
  slot:
    index: 8
    item: Sanchez TH
      type: Person
      first name: Travis H
      last name: Sanchez
      member of: Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  slot:
    index: 9
    item: Graham SM
      type: Person
      first name: Susan M
      last name: Graham
      member of: Department of Medicine, University of Washington, Seattle, Washington, USA.Department of Global Health, University of Washington, Seattle, Washington, USA.Department of Epidemiology, University of Washington, Seattle, Washington, USA.
created: 2024-6-14T06:43
date last updated: 2025-03-09
issued: 2024-07-02
dp: 2024 Jul 02
created: 2024-6-14T02:13
e ISSN: 1087-0415
has issn l: 1081-0730
issue: 7
has NLM journal title abbreviation: J Health Commun
publication name: Journal of health communication
language: eng
has national library of medicine journal id: 9604100
derived from: NLM
starting page: 467
ending page: 480
has place of publication: United States
has primary subject term: D006630Q000706Q000523
has primary subject term: D065129Q000706
has primary subject term: D015658Q000517Q000208
has primary subject term: D000072339Q000706Q000523
has primary subject term: D007802
has subject term: D006801
has subject term: D008297
has subject term: D000328
has subject term: D014481
has subject term: D055815
has subject term: D008875
has subject term: D000293
has subject term: D011795
has subject term: D003144
has subject term: D003142
has subject term: D010342Q000706Q000208Q000523
has subject term: D007722
source: J Health Commun. 2024-07-02;29(7):467-480.
volume: 29

Basic science observations link subretinal drusenoid deposit formation to retinal pigment epithelial hypoxia.
pmid: 38871936
has PII: 10.1038/s41433-024-03167-1
doi: 10.1038/s41433-024-03167-1
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Digsby K
      type: Person
      first name: Kaitlyn
      last name: Digsby
      member of: University of Michigan, Department of Pharmacology, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.
  slot:
    index: 2
    item: Zhang Q
      type: Person
      first name: Qitao
      last name: Zhang
      member of: University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA. qitaoz@umich.edu.
  slot:
    index: 3
    item: Miller JML
      type: Person
      first name: Jason M L
      last name: Miller
      member of: University of Michigan, Department of Ophthalmology and Visual Sciences, Cellular and Molecular Biology Program, Ann Arbor, MI, USA. miljason@umich.edu.
created: 2024-6-14T00:42
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-6-13T23:26
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 790
ending page: 792
has place of publication: England
source: Eye (Lond). 2025-03;39(4):790-792.
volume: 39

Artificial intelligence iterative reconstruction in abdominal CT of patients with irregular arm positioning: a case-by-case evaluation.
pmid: 38873726
abstract: Streak artifacts induced by irregular arm positioning have been an issue in diagnosing the abdomen.To illustrate the risk of misdiagnosis in abdominal computed tomography (CT) of patients with irregular arm positioning through a case-by-case evaluation and to test if it can be solved by the artificial intelligence iterative reconstruction (AIIR) algorithm.By reviewing 5220 cases of chest and thoracoabdominal CT, 64 patients with irregular arm positioning were enrolled, whose image data were reconstructed using AIIR in addition to routine hybrid iterative reconstruction (HIR). Lesion detection for livers, spleens, kidneys, gallbladders, and pancreas on AIIR images, performed by two radiologists, was compared with those on HIR images. Discrepancies arising from AIIR images included both cases with additional abnormalities and those with corrections made on previous detections. For cases with discrepancies, artifact scores for organs where discrepancies were found, and contrast-to-noise ratios (CNRs) of cysts with discrepancies were compared between two image sets.Additional abnormalities were detected for 15 cases: additional liver cirrhosis (n=2); additional gallbladder stone (n=1); additional cholecystitis (n=1), additional spleen nodule (n=1); additional kidney cysts (n=8); additional liver cysts (3); and additional spleen cyst (n=1). A spleen contusion was corrected for one case. All involved artifact scores were improved on AIIR images. CNRs of involved liver, kidney, and spleen cysts were improved by up to 539.7%, 538.5%, and 245.5%, respectively.Irregular arm positioning may induce a variety of misdiagnoses in abdominal CT, which is almost totally avoidable by the AIIR algorithm.
doi: 10.1177/02841851241258845
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Li J
      type: Person
      first name: Jin
      last name: Li
      member of: Department of Radiology, The Fourth Affiliated Hospital of Soochow University, Suzhou, PR China.
  slot:
    index: 2
    item: Meng T
      type: Person
      first name: Ting
      last name: Meng
      member of: Central Research Institute, United Imaging Healthcare, Shanghai, PR China.
  slot:
    index: 3
    item: Zhang G
      type: Person
      first name: Guozhi
      last name: Zhang
      member of: Central Research Institute, United Imaging Healthcare, Shanghai, PR China.
  slot:
    index: 4
    item: Yu X
      type: Person
      first name: Xiang
      last name: Yu
      member of: Department of Radiology, The Fourth Affiliated Hospital of Soochow University, Suzhou, PR China.
  slot:
    index: 5
    item: Lu Z
      type: Person
      first name: Zhihua
      last name: Lu
      member of: Department of Radiology, The Fourth Affiliated Hospital of Soochow University, Suzhou, PR China.
  slot:
    index: 6
    item: Zhang W
      type: Person
      first name: Weiguo
      last name: Zhang
      member of: Department of Radiology, The Fourth Affiliated Hospital of Soochow University, Suzhou, PR China.
created: 2024-6-14T06:42
date last updated: 2025-03-08
issued: 2024-08
dp: 2024 Aug
created: 2024-6-14T04:33
e ISSN: 1600-0455
has issn l: 0284-1851
issue: 8
has NLM journal title abbreviation: Acta Radiol
publication name: Acta radiologica (Stockholm, Sweden : 1987)
language: eng
has national library of medicine journal id: 8706123
derived from: NLM
starting page: 907
ending page: 912
has place of publication: England
has primary subject term: D000005Q000000981
has primary subject term: D056888Q000009Q000706
has primary subject term: D007090Q000379Q000706
has primary subject term: D004066Q000000981
has primary subject term: D003951Q000517
has primary subject term: D014057Q000379Q000706
has subject term: D012189
has subject term: D006801
has subject term: D008297
has subject term: D000293
has subject term: D055815
has subject term: D000328
has subject term: D008875
has subject term: D000368
has subject term: D000369
has subject term: D001132
has subject term: D016477
has subject term: D013909Q000000981
source: Acta Radiol. 2024-08;65(8):907-912.
volume: 65

Situational context of home-based sexual education in urban slums of Ibadan, Nigeria-evidence from a qualitative study.
pmid: 38885279
abstract: This study explores the influence of situational context on parent-adolescent communication about sexual and reproductive health (SRH) issues in the urban slums of Ibadan, Nigeria. A qualitative exploratory study was conducted in the Southeast and Northeast LGAs of Ibadan. Eight (8) vignette-based focus group discussions (FGDs) with parents and adolescents of both sexes were conducted in addition to four (4) key informant interviews (KIIs) with community and women's leaders. Interviews were tape-recorded, transcribed, and translated into English. Thematic analysis was adopted using ATLAS Ti 9 software. Findings portray SRH meanings and experiences, intergenerational cultural norms, and expectations for SRH, gender double standards in SRH discussion, streetwise SRH knowledge, and social media exposure as contexts that interfere with parent-adolescent communication on SRH issues. The findings show that despite understanding the need for SRH discussion, parents and adolescents lack effective communication on SRH issues due to the interference of unfiltered streetwise SRH knowledge and social media exposure. Also, SRH conversation between parents and adolescents promotes gender inequalities as different information is passed to adolescent girls and boys. Interventions that take into account situational occurrences must be geared towards enabling parents to give their adolescents early exposure to relevant, context-specific SRH knowledge.
rights: Copyright: © 2024 Taofeek Kolawole Aliyu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-23-21001
doi: 10.1371/journal.pone.0304200
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Aliyu TK
      type: Person
      first name: Taofeek Kolawole
      last name: Aliyu
      member of: Department of Sociology and Anthropology, Obafemi Awolowo University, Ile-Ife, Nigeria.Department of Sociology, Centre for Demographic and Ageing Research (CEDAR), Umeå University, Umeå, Sweden.
created: 2024-6-18T17:43
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-6-17T13:43
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 6
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0304200
has place of publication: United States
has primary subject term: D012736
has primary subject term: D011204
has primary subject term: D036301
has subject term: D006801
has subject term: D009549
has subject term: D005260
has subject term: D008297
has subject term: D000293
has subject term: D000328
has subject term: D014505
has subject term: D007722
has subject term: D008875
has subject term: D017144
has subject term: D010290Q000523
has subject term: http://id.nlm.nih.gov/mesh/D000074384
has subject term: D060728
has subject term: D055815
has subject term: D012725Q000523
source: PLoS One. 2024;19(6):e0304200.
volume: 19

The DIAPH3 linker specifies a β-actin network that maintains RhoA and Myosin-II at the cytokinetic furrow.
pmid: 38897998
abstract: Cytokinesis is the final step of the cell division cycle that leads to the formation of two new cells. Successful cytokinesis requires significant remodelling of the plasma membrane by spatially distinct β- and γ-actin networks. These networks are generated by the formin family of actin nucleators, DIAPH3 and DIAPH1 respectively. Here we show that β- and γ-actin perform specialized and non-redundant roles in cytokinesis and cannot substitute for one another. Expression of hybrid DIAPH1 and DIAPH3 proteins with altered actin isoform specificity relocalized cytokinetic actin isoform networks within the cell, causing cytokinetic failure. Consistent with this we show that β-actin networks, but not γ-actin networks, are required for the maintenance of non-muscle myosin II and RhoA at the cytokinetic furrow. These data suggest that independent and spatially distinct actin isoform networks form scaffolds of unique interactors that facilitate localized biochemical activities to ensure successful cell division.
rights: © 2024. The Author(s).
has PII: 10.1038/s41467-024-49427-2
doi: 10.1038/s41467-024-49427-2
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Shah R
      type: Person
      first name: Riya
      last name: Shah
      member of: Department of Biochemistry, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada.
  slot:
    index: 2
    item: Panagiotou TC
      type: Person
      first name: Thomas C
      last name: Panagiotou
      member of: Department of Molecular Genetics, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada.
  slot:
    index: 3
    item: Cole GB
      type: Person
      first name: Gregory B
      last name: Cole
      member of: Department of Biochemistry, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada.
  slot:
    index: 4
    item: Moraes TF
      type: Person
      first name: Trevor F
      last name: Moraes
      member of: Department of Biochemistry, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada.
  slot:
    index: 5
    item: Lavoie BD
      type: Person
      first name: Brigitte D
      last name: Lavoie
      member of: Department of Molecular Genetics, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada.
  slot:
    index: 6
    item: McCulloch CA
      type: Person
      first name: Christopher A
      last name: McCulloch
      member of: Faculty of Dentistry, University of Toronto, Toronto, ON, M5G 1G6, Canada.
  slot:
    index: 7
    item: Wilde A
      type: Person
      first name: Andrew
      last name: Wilde
      member of: Department of Biochemistry, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada. andrew.wilde@utoronto.ca.Department of Molecular Genetics, University of Toronto, 661 University Ave, Toronto, ON, M5G 1M1, Canada. andrew.wilde@utoronto.ca.
created: 2024-6-20T00:42
date last updated: 2025-03-09
issued: 2024-06-19
dp: 2024 Jun 19
created: 2024-6-19T23:13
e ISSN: 2041-1723
has issn l: 2041-1723
issue: 1
has NLM journal title abbreviation: Nat Commun
publication name: Nature communications
language: eng
has national library of medicine journal id: 101528555
derived from: NLM
pg: 5250
has place of publication: England
has primary subject term: D020742Q000378Q000235
has primary subject term: D048749
has primary subject term: D000080865Q000378Q000235
has primary subject term: D000199Q000378
has primary subject term: D024462Q000378
has primary subject term: D048868Q000378Q000235
has subject term: D006801
has subject term: D006367
has subject term: D000818
has subject term: D020033Q000378Q000235
source: Nat Commun. 2024-06-19;15(1):5250.
volume: 15

The association of non-severe COVID-19 infection and progression to frailty among robust older veterans.
pmid: 38901116
abstract: Studies have shown that frailty was increased in hospitalized COVID-19 patients. However, it is not clear whether non-severe COVID-19 increases the risk for pre-frailty and frailty development. Our study aimed to determine the risk of developing frailty and pre-frailty in robust veterans who contracted non-severe COVID-19.We conducted a retrospective cohort study to assess the association of SARS-CoV-2 infection with the development of pre-frailty and frailty status among robust U.S. veterans using VA COVID-19 Shared Data Resource. We included patients 55 years and older who had at least one SARS-CoV-2 testing between March 15, 2020, and November 30, 2020, had been active patients in the past 12 months, and had a VA frailty index of zero (robust status) at the time of testing. Cox proportional hazard model was used to assess the association between COVID-19 infection and developing frailty or pre-frailty and frailty. We also assessed the association by patients' age groups, sex, and race.We identified 82070 veterans mean age 68.3 ± 7.8, 74738 (91.1%) male, 53899 (65.7%) white, 7557 (9.2%) with mild COVID-19 infection. Over the follow up period of 36 months, testing positive for COVID-19 was associated with a 66% increase in the hazard of becoming frail (adjusted HR = 1.66, 95%CI: 1.32-2.08), and a 68% increase in the hazard of becoming pre-frail (adjusted HR = 1.68, 95%CI: 1.45-1.94). Among male patients, mild COVID-19 infection was associated with a 54% increase in the hazard of becoming frail (adjusted HR = 1.54, 95% CI: 1.21-1.96), while among female patients there was a 330% increase (adjusted HR = 4.30, 95% CI: 2.13-8.64).Non-severe COVID-19 infection that occurred in robust older adults increased the risk of developing frailty. Further multi-center prospective cohort studies evaluating the mechanism of action and clinical trials of treatment options for post-COVID frailty are indicated in Veterans to support clinical care.
rights: Published by Elsevier Masson SAS.
has PII: S1279-7707(24)00383-X
doi: 10.1016/j.jnha.2024.100296
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Resendes NM
      type: Person
      first name: Natasha M
      last name: Resendes
      member of: Miami VA (Veterans Administration) Healthcare System Geriatric Research, Education and Clinical Center (GRECC), Miami, Florida, USA; Dept. of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address: natasha.resendes@va.gov.
  slot:
    index: 2
    item: Bradley J
      type: Person
      first name: Jerry
      last name: Bradley
      member of: Dept. of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  slot:
    index: 3
    item: Tang F
      type: Person
      first name: Fei
      last name: Tang
      member of: Miami VA (Veterans Administration) Healthcare System Geriatric Research, Education and Clinical Center (GRECC), Miami, Florida, USA.
  slot:
    index: 4
    item: Hammel IS
      type: Person
      first name: Iriana S
      last name: Hammel
      member of: Miami VA (Veterans Administration) Healthcare System Geriatric Research, Education and Clinical Center (GRECC), Miami, Florida, USA; Dept. of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  slot:
    index: 5
    item: Ruiz JG
      type: Person
      first name: Jorge G
      last name: Ruiz
      member of: Memorial Healthcare System, Hollywood, Florida, USA; Dept of Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, Florida, USA.
created: 2024-6-21T00:42
date last updated: 2025-03-08
issued: 2024-08
dp: 2024 Aug
created: 2024-6-20T18:02
e ISSN: 1760-4788
has issn l: 1279-7707
issue: 8
has NLM journal title abbreviation: J Nutr Health Aging
publication name: The journal of nutrition, health & aging
language: eng
has national library of medicine journal id: 100893366
derived from: NLM
pg: 100296
has place of publication: France
has primary subject term: http://id.nlm.nih.gov/mesh/D000086402
has primary subject term: D000073496Q000453Q000473Q000821
has primary subject term: D014728Q000706
has primary subject term: D012720
has primary subject term: D000094024Q000150Q000453
has subject term: D012189
has subject term: D014481Q000453
has subject term: D014493Q000706
has subject term: D016016
has subject term: D012307
has subject term: D000367
has subject term: D012737
has subject term: D044469Q000706
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D008875
has subject term: D000368
has subject term: D018450
source: J Nutr Health Aging. 2024-08;28(8):100296.
volume: 28

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa.
pmid: 38920394
abstract: Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can also be induced via genetic inactivation of PG biogenesis factors such as the endopeptidase DacB that cleaves PG crosslinks. Mutants in dacB occur in beta-lactam-resistant clinical isolates of P. aeruginosa, but it has remained unclear why DacB inactivation promotes ampC induction. Similarly, the inactivation of lytic transglycosylase (LT) enzymes such as SltB1 that cut PG glycans has also been associated with ampC induction and beta-lactam resistance. Given that LT enzymes are capable of producing AMP products that serve as ampC inducers, this latter observation has been especially difficult to explain. Here, we show that ampC induction in sltB1 or dacB mutants requires another LT enzyme called MltG. In Escherichia coli, MltG has been implicated in the degradation of nascent PG strands produced upon beta-lactam treatment. Accordingly, in P. aeruginosa sltB1 and dacB mutants, we detected the MltG-dependent production of pentapeptide-containing AMP products that are signatures of nascent PG degradation. Our results therefore support a model in which SltB1 and DacB use their PG-cleaving activity to open space in the PG matrix for the insertion of new material. Thus, their inactivation mimics low-level beta-lactam treatment by reducing the efficiency of new PG insertion into the wall, causing the degradation of some nascent PG material by MltG to produce the ampC-inducing signal.Inducible beta-lactamases like the ampC system of Pseudomonas aeruginosa are a common determinant of beta-lactam resistance among gram-negative bacteria. The regulation of ampC is elegantly tuned to detect defects in cell wall synthesis caused by beta-lactam drugs. Studies of mutations causing ampC induction in the absence of drug therefore pro[cell cut: 2452 characters, first 2000 kept]
doi: 10.1128/mbio.01419-24
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Gyger J
      type: Person
      first name: Joël
      last name: Gyger
      member of: Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  slot:
    index: 2
    item: Torrens G
      type: Person
      first name: Gabriel
      last name: Torrens
      member of: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Center for Microbial Research (UCMR), Umea, Sweden.Department of Molecular Biology, Science for Life Laboratory (SciLifeLab), Umeå University, Umeå, Sweden.
  slot:
    index: 3
    item: Cava F
      type: Person
      first name: Felipe
      last name: Cava
      member of: Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Center for Microbial Research (UCMR), Umea, Sweden.Department of Molecular Biology, Science for Life Laboratory (SciLifeLab), Umeå University, Umeå, Sweden.
  slot:
    index: 4
    item: Bernhardt TG
      type: Person
      first name: Thomas G
      last name: Bernhardt
      member of: Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 5
    item: Fumeaux C
      type: Person
      first name: Coralie
      last name: Fumeaux
      member of: Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
created: 2024-6-26T12:42
date last updated: 2025-03-09
issued: 2024-07-17
dp: 2024 Jul 17
created: 2024-6-26T09:04
e ISSN: 2150-7511
issue: 7
has NLM journal title abbreviation: mBio
publication name: mBio
language: eng
has national library of medicine journal id: 101519231
derived from: NLM
pg: e0141924
has place of publication: United States
has primary subject term: D011550Q000235Q000201Q000187Q000378
has primary subject term: D002473Q000378Q000187
has primary subject term: D001618Q000235Q000378
has primary subject term: D001426Q000235Q000378
has subject term: D018440Q000235
has subject term: D010641
has subject term: D010457Q000378
has subject term: D000900Q000494
has subject term: D047090Q000494Q000378
has subject term: D015964
source: mBio. 2024-07-17;15(7):e0141924.
volume: 15

Generative AI for diabetologists: a concise tutorial on dataset analysis.
pmid: 38932811
abstract: This paper aims to provide a tutorial for diabetologists and endocrinologists on using generative AI to analyze datasets. It is designed to be accessible to those new to generative AI or without programming experience.The paper presents three examples using a real diabetes dataset. The examples demonstrate binary classification with the 'Group' variable, cross-validation analysis, and NT-proBNP regression.The binary classification achieved a prediction accuracy of nearly 0.9. However, the NT-proBNP regression was not successful with this dataset. The calculated R-squared values indicate a poor fit between the predicted model and the raw data.The unsuccessful NT-proBNP regression may be due to insufficient training data or the need for additional determinants. The dataset may be too small or new metrics may be required to accurately predict NT-proBNP regression values. It is crucial for users to verify the generated codes to ensure that they can achieve their desired objectives.
rights: © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 1377
doi: 10.1007/s40200-023-01377-0
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Takefuji Y
      type: Person
      first name: Yoshiyasu
      last name: Takefuji
      member of: Faculty of Data Science, Musashino University, 3-3-3 Ariake Koto-Ku, Tokyo, 135-8181 Japan.
created: 2024-6-27T06:42
date last updated: 2025-03-09
issued: 2024-06
dp: 2024 Jun
created: 2024-6-27T04:24
ISSN: 2251-6581
has issn l: 2251-6581
issue: 1
has NLM journal title abbreviation: J Diabetes Metab Disord
publication name: Journal of diabetes and metabolic disorders
language: eng
has national library of medicine journal id: 101590741
derived from: NLM
starting page: 1419
ending page: 1423
has place of publication: Switzerland
source: J Diabetes Metab Disord. 2024-06;23(1):1419-1423.
volume: 23

Enhancement of keratinocyte survival and migration elicited by interleukin 24 upregulation in dermal microvascular endothelium upon welding-fume exposure.
pmid: 38940434
abstract: Occupational exposure to welding fumes constitutes a serious health concern. Although the effects of fumes on the respiratory tract have been investigated, few apparent reports were published on their effects on the skin. The purpose of this study was to investigate the effects of exposure to welding fumes on skin cells, focusing on interleukin-24 (IL-24), a cytokine involved in the pathophysiology of skin conditions, such as atopic dermatitis and psoriasis. Treatment with welding fumes increased IL-24 expression and production levels in human dermal microvascular endothelial cells (HDMEC) which were higher than that in normal human epidermal keratinocytes. IL-24 levels in Trolox and deferoxamine markedly suppressed welding fume-induced IL-24 expression in HDMEC, indicating that oxidative stress may be involved in this cytokine expression. IL-24 released from HDMEC protected keratinocytes from welding fume-induced damage and enhanced keratinocyte migration. Serum IL-24 was higher in welding workers than in general subjects and was positively correlated with elevated serum levels of 8-hydroxy-2'-deoxyguanosine, an oxidative stress marker. In summary, welding fumes enhanced IL-24 expression in HDMEC, stimulating keratinocyte survival and migration. IL-24 expression in endothelial cells may act as an adaptive response to welding-fume exposure in the skin.
doi: 10.1080/15287394.2024.2372403
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Kono M
      type: Person
      first name: Maori
      last name: Kono
      member of: Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.Advanced Technology Institute, Mandom Corporation, Osaka, Japan.
  slot:
    index: 2
    item: Ishihara N
      type: Person
      first name: Nami
      last name: Ishihara
      member of: Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
  slot:
    index: 3
    item: Nakane T
      type: Person
      first name: Tatsuto
      last name: Nakane
      member of: Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
  slot:
    index: 4
    item: Nabetani Y
      type: Person
      first name: Yu
      last name: Nabetani
      member of: Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Miyazaki, Japan.
  slot:
    index: 5
    item: Kajino M
      type: Person
      first name: Mizuo
      last name: Kajino
      member of: Meteorological Research Institute, Japan Meteorological Agency, Tsukuba, Ibaraki, Japan.
  slot:
    index: 6
    item: Okuda T
      type: Person
      first name: Tomoaki
      last name: Okuda
      member of: Faculty of Science and Technology, Keio University, Tokyo, Kanagawa, Japan.
  slot:
    index: 7
    item: Hayashi M
      type: Person
      first name: Masahiko
      last name: Hayashi
      member of: Faculty of Science, Fukuoka University, Fukuoka, Japan.
  slot:
    index: 8
    item: Koriyama C
      type: Person
      first name: Chihaya
      last name: Koriyama
      member of: Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  slot:
    index: 9
    item: Vogel CFA
      type: Person
      first name: Christoph F A
      last name: Vogel
      member of: Department of Environmental Toxicology, University of California, Davis, CA, USA.Center for Health and the Environment, University of California, Davis, CA, USA.
  slot:
    index: 10
    item: Tsuji M
      type: Person
      first name: Mayumi
      last name: Tsuji
      member of: Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
  slot:
    index: 11
    item: Ishihara Y
      type: Person
      first name: Yasuhiro
      last name: Ishihara
      member of: Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.Center for Health and the Environment, University of California, Davis, CA, USA.
created: 2024-6-28T12:43
date last updated: 2025-03-09
issued: 2024-10
dp: 2024 10
created: 2024-6-28T08:02
ISSN: 1528-7394
has issn l: 0098-4108
issue: 19
has NLM journal title abbreviation: J Toxicol Environ Health A
publication name: Journal of toxicology and environmental health. Part A
language: eng
has national library of medicine journal id: 100960995
derived from: NLM
starting page: 792
ending page: 810
has place of publication: England
has primary subject term: D002465Q000187
has primary subject term: D002470Q000187
has primary subject term: D007378Q000378
has primary subject term: D015603Q000187
has primary subject term: D015854Q000187
has primary subject term: D014896
has subject term: D000328
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D000395Q000633Q000009
has subject term: D002478
has subject term: D042783Q000187Q000378
has subject term: D016273Q000009
has subject term: D018384Q000187
has subject term: D012867Q000378Q000187Q000098
source: J Toxicol Environ Health A. 2024-10;87(19):792-810.
volume: 87

Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study.
pmid: 38950286
abstract: BackgroundRetinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare, autosomal dominant, universally fatal disease without effective treatment options. This study explores the safety and preliminary efficacy of crizanlizumab, a humanized monoclonal antibody against P-selectin approved for the prevention of sickle cell crises, in slowing retinal nonperfusion and preserving vision in patients with RVCL-S.METHODSEleven patients with RVCL-S with confirmed exonuclease 3 prime repair exonuclease 1 (TREX1) mutations received monthly crizanlizumab infusions over 2 years. The study measured the nonperfusion index within 3 retinal zones and the total retina with fluorescein angiography, visual acuity, intraocular pressure (IOP), and optical coherence tomography central subfield thickness (CST) at baseline, 1 year, and 2 years. A mixed repeated-measures analysis was performed to assess the progression rates and changes from baseline.RESULTSEleven participants received crizanlizumab infusions. All of the participants tolerated crizanlizumab well, with 8 of 11 (72.7%) reporting mild adverse effects such as nausea, fatigue, and gastrointestinal symptoms. The change in total retinal nonperfusion was 7.22% [4.47, 9.97] in year 1 and -0.69% [-4.06, 2.68] in year 2 (P < 0.001). In the mid periphery, the change in nonperfusion was 10.6% [5.1, 16.1] in year 1 and -0.68% [-3.98, 5.35] in year 2 (P < 0.01), demonstrating a reduction in progression of nonperfusion in the second year of treatment. Visual acuity, IOP, and CST remained stable.CONCLUSIONCrizanlizumab has an acceptable safety profile. These results show promising potential for examining crizanlizumab in larger studies of RVCL-S and similar small-vessel diseases and for using the retina as a biomarker for systemic disease.Trial registrationClinicalTrials.gov NCT04611880.FUNDINGThe Clayco Foundation; DeNardo Education and Research Foundation Grant; Jeffrey T. Fort Innovation Fund; Site[cell cut: 2238 characters, first 2000 kept]
has PII: 180916
doi: 10.1172/JCI180916
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Wang WX
      type: Person
      first name: Wilson X
      last name: Wang
      member of: John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.
  slot:
    index: 2
    item: Spiegelman D
      type: Person
      first name: Dan
      last name: Spiegelman
      member of: John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.
  slot:
    index: 3
    item: Rao PK
      type: Person
      first name: P Kumar
      last name: Rao
      member of: John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.
  slot:
    index: 4
    item: Rhee RL
      type: Person
      first name: Rennie L
      last name: Rhee
      member of: Department of Medicine and RVCL Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
  slot:
    index: 5
    item: Ford AL
      type: Person
      first name: Andria L
      last name: Ford
      member of: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
  slot:
    index: 6
    item: Miner JJ
      type: Person
      first name: Jonathan J
      last name: Miner
      member of: Departments of Medicine and Microbiology, Colton Center for Autoimmunity, and RVCL Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
  slot:
    index: 7
    item: Apte RS
      type: Person
      first name: Rajendra S
      last name: Apte
      member of: John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.Department of Medicine, Washington University, St. Louis, Missouri, USA.
created: 2024-7-1T18:43
date last updated: 2025-03-09
issued: 2024-05-07
dp: 2024 May 07
created: 2024-7-1T15:53
e ISSN: 1558-8238
has issn l: 0021-9738
issue: 12
has NLM journal title abbreviation: J Clin Invest
publication name: The Journal of clinical investigation
language: eng
has national library of medicine journal id: 7802877
derived from: NLM
has place of publication: United States
has primary subject term: D061067Q000627Q000009Q000008
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000328
has subject term: D008875
has subject term: D056784Q000188
has subject term: D005090Q000235
has subject term: D012164Q000188
has subject term: D010750
source: J Clin Invest. 2024-05-07;134(12):.
volume: 134

Evidence-based Prostate Cancer Screening Interventions for Black Men: A Systematic Review.
pmid: 38987514
abstract: Prostate cancer is the second leading cause of death for men in the U.S. and Black men are twice as likely to die from the disease. However, prostate cancer, if diagnosed at an earlier stage, is curable. The purpose of this review is to identify prostate cancer screening clinical trials that evaluate screening decision-making processes of Black men.The databases PubMed, Ovid MEDLINE, CINAHL Plus, and PsychInfo were utilized to examine peer-reviewed publications between 2017 and 2023. Data extracted included implementation plans, outcome measures, intervention details, and results of the study. The Critical Appraisal Skills Programme was used to assess the quality of the evidence presented.Of the 206 full-text articles assessed, three were included in this review. Educational interventions about prostate cancer knowledge with shared and informed decision-making (IDM) features, as well as counseling, treatment options, and healthcare navigation information, may increase prostate cancer screening participation among Black men. Additionally, health partner educational interventions may not improve IDM related to screening participation. The quality of the evidence presented in each article was valid and potentially impactful to the community.Black men face various social determinants of health barriers related to racism, discrimination, cost of health services, time away from work, and lack of trust in the healthcare system when making health-related decisions, including prostate cancer screening participation. A multifactorial intervention approach is required to address these inequities faced by Black men especially as prostate cancer is curable when diagnosed at an earlier stage.
rights: © 2024. The Author(s).
has PII: 10.1007/s40615-024-02085-y
doi: 10.1007/s40615-024-02085-y
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lopez A
      type: Person
      first name: Abigail
      last name: Lopez
      member of: Department of Health Sciences, Crean College of Health and Behavioral Sciences, Chapman University, One University Drive, Orange, CA, USA.
  slot:
    index: 2
    item: Bailey JT
      type: Person
      first name: Jared T
      last name: Bailey
      member of: Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  slot:
    index: 3
    item: Galloway D
      type: Person
      first name: Dorothy
      last name: Galloway
      member of: River Oak Center for Children, Sacramento, CA, USA.
  slot:
    index: 4
    item: Woods-Burnham L
      type: Person
      first name: Leanne
      last name: Woods-Burnham
      member of: Department of Surgery, Morehouse School of Medicine, Atlanta, GA, USA.
  slot:
    index: 5
    item: Montgomery SB
      type: Person
      first name: Susanne B
      last name: Montgomery
      member of: School of Behavioral Health, Loma Linda University, Loma Linda, CA, USA.
  slot:
    index: 6
    item: Kittles R
      type: Person
      first name: Rick
      last name: Kittles
      member of: Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
  slot:
    index: 7
    item: Teteh-Brooks DK
      type: Person
      first name: Dede K
      last name: Teteh-Brooks
      member of: Department of Health Sciences, Crean College of Health and Behavioral Sciences, Chapman University, One University Drive, Orange, CA, USA. teteh@chapman.edu.
created: 2024-7-11T00:42
date last updated: 2025-03-09
issued: 2024-07-10
dp: 2024 Jul 10
created: 2024-7-10T23:29
e ISSN: 2196-8837
has issn l: 2196-8837
has NLM journal title abbreviation: J Racial Ethn Health Disparities
publication name: Journal of racial and ethnic health disparities
language: eng
has national library of medicine journal id: 101628476
derived from: NLM
has place of publication: Switzerland
source: J Racial Ethn Health Disparities. 2024-07-10;():.

Indazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity.
pmid: 38997232
abstract: Tuberculosis remains a leading cause of death from a single infection worldwide. Drug resistance to existing and even new antimycobacterials calls for research into novel targets and unexplored mechanisms of action. Recently we reported on the development of tight-binding inhibitors of Mycobacterium tuberculosis (Mtb) lipoamide dehydrogenase (Lpd), which selectively inhibit the bacterial but not the human enzyme based on a differential modality of inhibitor interaction with these targets. Here we report on the striking improvement in inhibitor residence time on the Mtb enzyme associated with scaffold progression from an indazole to 2-cyanoindole. Cryo-EM of Lpd with the bound 2-cyanoindole inhibitor 19 confirmed displacement of the buried water molecule deep in the binding channel with a cyano group. The ensuing hours-long improvement in on-target residence time is associated with enhanced antibacterial activity in axenic culture and in primary mouse macrophages. Resistance to 2-cyanoindole inhibitors involves mutations within the inhibitor binding site that have little effect on inhibitor affinity but change the modality of inhibitor-target interaction, resulting in fast dissociation from Lpd. These findings underscore that on-target residence time is a major determinant of antibacterial activity and in vivo efficacy.
rights: © 2024 Wiley-VCH GmbH.
doi: 10.1002/anie.202407276
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Sun S
      type: Person
      first name: Shan
      last name: Sun
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.
  slot:
    index: 2
    item: Ginn J
      type: Person
      first name: John
      last name: Ginn
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.
  slot:
    index: 3
    item: Kochanczyk T
      type: Person
      first name: Tomasz
      last name: Kochanczyk
      member of: Structural Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
  slot:
    index: 4
    item: Arango N
      type: Person
      first name: Nancy
      last name: Arango
      member of: Structural Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
  slot:
    index: 5
    item: Jiang X
      type: Person
      first name: Xiuju
      last name: Jiang
      member of: Department of Microbiology and Immunology, Weill Cornell Medicine, 413 East 69 Street, New York, NY 10021, USA.
  slot:
    index: 6
    item: Huggins DJ
      type: Person
      first name: David J
      last name: Huggins
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.Department of Physiology and Biophysics, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10021, USA.
  slot:
    index: 7
    item: Bean J
      type: Person
      first name: James
      last name: Bean
      member of: Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
  slot:
    index: 8
    item: Michino M
      type: Person
      first name: Mayako
      last name: Michino
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.
  slot:
    index: 9
    item: Baxt L
      type: Person
      first name: Leigh
      last name: Baxt
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.
  slot:
    index: 10
    item: Liverton N
      type: Person
      first name: Nigel
      last name: Liverton
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.
  slot:
    index: 11
    item: Meinke PT
      type: Person
      first name: Peter T
      last name: Meinke
      member of: Sanders Tri-Institutional Therapeutics Discovery Institute, Bronk Laboratory, 1230 York Avenue, Box 122, New York, NY 10065, USA.
  slot:
    index: 12
    item: Bryk R
      type: Person
      first name: Ruslana
      last name: Bryk
      member of: Department of Microbiology and Immunology, Weill Cornell Medicine, 413 East 69 Street, New York, NY 10021, USA.
created: 2024-7-13T07:42
date last updated: 2025-03-09
issued: 2024-10-24
dp: 2024 Oct 24
created: 2024-7-12T22:12
e ISSN: 1521-3773
has issn l: 1433-7851
issue: 44
has NLM journal title abbreviation: Angew Chem Int Ed Engl
publication name: Angewandte Chemie (International ed. in English)
language: eng
has national library of medicine journal id: 0370543
derived from: NLM
pg: e202407276
has place of publication: Germany
has primary subject term: D007211Q000737Q000494
has primary subject term: D009169Q000187Q000201
has primary subject term: D008058Q000037Q000378
has primary subject term: D007191Q000737Q000494
has subject term: D004791Q000494Q000737Q000138
has subject term: D000818
has subject term: D008826
has subject term: D051379
has subject term: D000900Q000494Q000737
has subject term: D000995Q000494Q000737
has subject term: D013329
has subject term: D015394
has subject term: D006801
source: Angew Chem Int Ed Engl. 2024-10-24;63(44):e202407276.
volume: 63

Enzymatic control of intermolecular interactions for generating synthetic nanoarchitectures in cellular environment.
pmid: 39011064
abstract: Nanoarchitectonics, as a technology to arrange nano-sized structural units such as molecules in a desired configuration, requires nano-organization, which usually relies on intermolecular interactions. This review briefly introduces the development of using enzymatic reactions to control intermolecular interactions for generating artificial nanoarchitectures in a cellular environment. We begin the discussion with the early examples and uniqueness of enzymatically controlled self-assembly. Then, we describe examples of generating intracellular nanostructures and their relevant applications. Subsequently, we discuss cases of forming nanostructures on the cell surface via enzymatic reactions. Following that, we highlight the use of enzymatic reactions for creating intercellular nanostructures. Finally, we provide a summary and outlook on the promises and future direction of this strategy. Our aim is to give an updated introduction to the use of enzymatic reaction in regulating intermolecular interactions, a phenomenon ubiquitous in biology but relatively less explored by chemists and materials scientists. Our goal is to stimulate new developments in this simple and versatile approach for addressing societal needs.
rights: © 2024 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group.
has PII: 2373045
doi: 10.1080/14686996.2024.2373045
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Tan W
      type: Person
      first name: Weiyi
      last name: Tan
      member of: Department of Chemistry, Brandeis University, Waltham, MA, USA.
  slot:
    index: 2
    item: Zhang Q
      type: Person
      first name: Qiuxin
      last name: Zhang
      member of: Department of Chemistry, Brandeis University, Waltham, MA, USA.
  slot:
    index: 3
    item: Lee M
      type: Person
      first name: Mikki
      last name: Lee
      member of: Department of Chemistry, Brandeis University, Waltham, MA, USA.Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore.
  slot:
    index: 4
    item: Lau W
      type: Person
      first name: William
      last name: Lau
      member of: Department of Chemistry, Brandeis University, Waltham, MA, USA.
  slot:
    index: 5
    item: Xu B
      type: Person
      first name: Bing
      last name: Xu
      member of: Department of Chemistry, Brandeis University, Waltham, MA, USA.
created: 2024-7-16T06:42
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-7-16T04:06
ISSN: 1468-6996
has issn l: 1468-6996
issue: 1
has NLM journal title abbreviation: Sci Technol Adv Mater
publication name: Science and technology of advanced materials
language: eng
has national library of medicine journal id: 101614420
rights holder: Enzymatic reactions in cells create precise nanoarchitectures, offering insights into cell biology through controllable nanoarchitectonics, as shown by numerous examples in this review.
derived from: NLM
pg: 2373045
has place of publication: United States
source: Sci Technol Adv Mater. 2024;25(1):2373045.
volume: 25

Recurrent tethered cord: outcome and follow-up of 20 de-thetering for symptomatic spina bifida: choort study.
pmid: 39017694
abstract: The objective of this study was to evaluate the prevalence of tethered cord among patients in the postoperative period of open and occult spina bifida. To identify warning signs for its early diagnosis, as well as outcomes after the new surgical approach.Retrospective study of patients followed at the Pediatric Neurosurgery Department of the Federal University of São Paulo with spinal dysraphism. Signs and symptoms indicating reoperation were collected, and postoperative results were classified as improved, unchanged, or worsened.222 medical records of patients diagnosed with spinal dysraphism were evaluated. Symptomatic Tethered Cord Syndrome (STCS) was identified in 30 patients (13.51%), with clinical manifestations related to orthopedic deformities (66.7%), neurological deficits (56.7%), urological dysfunction (50%), and intestinal dysfunction (40%). 20 cases underwent surgery for tethered cord release. The mean age at the time of surgery was 7.7 ± 4.9 years, with 13 female patients (65%). In the postoperative evaluation, improvement in low back pain (90.9%), urological pattern, and urinary tract infection episodes (45.4%) were particularly noteworthy. 3 patients (33.3%) with constipation showed improvement, and one worsened (11.1%). Improvement in ambulation was seen in two cases (16.7%). Low back pain was the first symptom to improve after surgery, with an average time of 1.3 months, followed by changes in the urological pattern at 15.6 months. Improvement in constipation was observed in the first month in 2 cases (66.7%), positive changes in ambulation were observed around 7 months after surgery, and only one case showed improvement in clubfoot correction.The prevalence of tethered cord recurrence after primary correction surgery for open or occult neural tube closure defects was similar to that found in the literature. The results were encouraging, with good postoperative evolution of patients, especially in the improvement of low back pain and urological sym[cell cut: 2006 characters, first 2000 kept]
rights: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00381-024-06537-y
doi: 10.1007/s00381-024-06537-y
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: de Almeida VC
      type: Person
      first name: Vitoria Cristina
      last name: de Almeida
      member of: Universidade Federal de São Paulo, Sao Paulo, SP, Brazil. almeida.vitoria@unifesp.br.
  slot:
    index: 2
    item: Leite MTC
      type: Person
      first name: Mila Torii Correa
      last name: Leite
      member of: Department of Pediatric surgery, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
  slot:
    index: 3
    item: Dastoli PA
      type: Person
      first name: Patricia Alessandra
      last name: Dastoli
      member of: Department of Neurosurgery, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
  slot:
    index: 4
    item: Watanabe RA
      type: Person
      first name: Rodrigo Akira
      last name: Watanabe
      member of: Department of Neurosurgery, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
  slot:
    index: 5
    item: Zanon N
      type: Person
      first name: Nelci
      last name: Zanon
      member of: Department of Neurosurgery, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.
created: 2024-7-17T12:44
date last updated: 2025-03-08
issued: 2024-11
dp: 2024 Nov
created: 2024-7-17T11:04
e ISSN: 1433-0350
has issn l: 0256-7040
issue: 11
has NLM journal title abbreviation: Childs Nerv Syst
publication name: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
language: eng
has national library of medicine journal id: 8503227
derived from: NLM
starting page: 3703
ending page: 3708
has place of publication: Germany
has primary subject term: D009436Q000175Q000453Q000209
has primary subject term: D016135Q000150Q000601
has primary subject term: D012086Q000706
has primary subject term: D019635Q000379Q000706
has subject term: D012189
has subject term: D015995
has subject term: D006801
has subject term: D005260
has subject term: D002648
has subject term: D011184
has subject term: D016896
source: Childs Nerv Syst. 2024-11;40(11):3703-3708.
volume: 40

Saliva assay: a call for methodological standardization.
pmid: 39058348
abstract: The oral cavity provides an ideal environment for microorganisms, including bacteria, viruses, and fungi, to flourish. Increasing attention has been focused on the connection between the oral microbiome and both oral and systemic diseases, spurring active research into the collection and analysis of specimens for healthcare purposes. Among the various methods for analyzing the oral microbiome, saliva analysis is especially prominent. Saliva samples, which can be collected non-invasively, provide information on the systemic health and oral microbiome composition of an individual. This review was performed to evaluate the current state of the relevant research through an examination of the literature and to suggest an appropriate assay method for investigating the oral microbiome. We analyzed articles published in English in SCI(E) journals after January 1, 2000, ultimately selecting 53 articles for review. Articles were identified through keyword searches in the PubMed, Embase, Cochrane, Web of Science, and CINAHL databases. Three experienced researchers conducted full-text assessments following title and abstract screening to select appropriate papers. Subsequently, they organized and analyzed the desired data. Our review revealed that most studies utilized unstimulated saliva samples for oral microbiome analysis. Of the 53 studies examined, 29 identified relationships between the oral microbiome and various diseases, such as oral disease, Behçet disease, cancer, and oral lichen planus. However, the studies employed diverse methods of collection and analysis, which compromised the reliability and accuracy of the findings. To address the limitations caused by methodological inconsistencies, a standardized saliva assay should be established.
rights: Copyright © 2025. Korean Academy of Periodontology.
has PII: 54.e13
doi: 10.5051/jpis.2304180209
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Baek HJ
      type: Person
      first name: Hyeong-Jin
      last name: Baek
      member of: Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea.
  slot:
    index: 2
    item: Kim KS
      type: Person
      first name: Keun-Suh
      last name: Kim
      member of: Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea.
  slot:
    index: 3
    item: Kwoen M
      type: Person
      first name: MinJeong
      last name: Kwoen
      member of: Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea.
  slot:
    index: 4
    item: Park ES
      type: Person
      first name: Eun-Sun
      last name: Park
      member of: Medical Library, College of Medicine, Seoul National University, Seoul, Korea.
  slot:
    index: 5
    item: Lee HJ
      type: Person
      first name: Hyo-Jung
      last name: Lee
      member of: Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea. periolee@gmail.com.
  slot:
    index: 6
    item: Park KU
      type: Person
      first name: Kyoung-Un
      last name: Park
      member of: Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. m91w95pf@snu.ac.kr.
created: 2024-7-26T12:47
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-7-26T10:33
ISSN: 2093-2278
has issn l: 2093-2278
issue: 1
has NLM journal title abbreviation: J Periodontal Implant Sci
publication name: Journal of periodontal & implant science
language: eng
has national library of medicine journal id: 101526931
derived from: NLM
starting page: 2
ending page: 17
has place of publication: Korea (South)
source: J Periodontal Implant Sci. 2025-02;55(1):2-17.
volume: 55

Assessment of variations in the nasopalatine canal on CBCT: considerations from an anatomical point of view.
pmid: 39058352
abstract: The nasopalatine canal (NPC) is one of the most significant anatomical markers in the anterior maxillary region. Its location is quite important, especially for implant placement. Therefore, the purpose of this study was to use cone-beam computed tomography (CBCT) to evaluate the morphology, size, and anatomic variations of the NPC.A total of 150 individual CBCT images were assessed in various sections to evaluate the dimensions, morphology, and extent of the NPC. Reformatted sagittal images were chosen to classify the shape and course of the canal. The Student's t-test, the χ² test, and Pearson correlation coefficients were used.The NPC was longer in males than in females, and the mediolateral diameter of the canal was greater in older adults. In sagittal sections, the canal predominantly exhibits a cylindrical shape, while a spindle shape is the least common. In coronal sections, a single shape is most frequently observed, with a Y-shape being the least common. Regarding the orientation of the canal, slanted canals are more prevalent, whereas vertically curved canals are rare. Typically, 2 canal openings are observed, with 4 openings being the least common.The current study highlights the challenges associated with identifying the anatomical appearance and variations of the NPC. Consequently, possessing a thorough understanding of this anatomy is essential before undertaking any surgical procedures, such as implant placement. This knowledge helps prevent complications such as nerve injury-related loss of sensation, bleeding due to blood vessel injury, and the development of a nasopalatine duct cyst following trauma to the canal during surgery.
rights: Copyright © 2025. Korean Academy of Periodontology.
has PII: 54.e20
doi: 10.5051/jpis.2401300065
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Yadav U
      type: Person
      first name: Utkarsh
      last name: Yadav
      member of: Oral Medicine and Radiology, Faculty of Dental Sciences, IMS, BHU, Varanasi, Uttar Pradesh, India.
  slot:
    index: 2
    item: Shenoy N
      type: Person
      first name: Nandita
      last name: Shenoy
      member of: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, India. nandita.shenoy@manipal.edu.
  slot:
    index: 3
    item: Ahmed J
      type: Person
      first name: Junaid
      last name: Ahmed
      member of: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, India.
  slot:
    index: 4
    item: Sujir N
      type: Person
      first name: Nanditha
      last name: Sujir
      member of: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, India.
  slot:
    index: 5
    item: M A
      type: Person
      first name: Archana
      last name: M
      member of: Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, India.
  slot:
    index: 6
    item: Gupta A
      type: Person
      first name: Aarti
      last name: Gupta
      member of: Oxford Dental College, Rajiv Gandhi University, Bangalore, Karnataka, India.
created: 2024-7-26T12:47
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-7-26T10:33
ISSN: 2093-2278
has issn l: 2093-2278
issue: 1
has NLM journal title abbreviation: J Periodontal Implant Sci
publication name: Journal of periodontal & implant science
language: eng
has national library of medicine journal id: 101526931
derived from: NLM
starting page: 62
ending page: 71
has place of publication: Korea (South)
source: J Periodontal Implant Sci. 2025-02;55(1):62-71.
volume: 55

Clinical evaluation of implants placed within or beyond the boundaries of the alveolar ridge preservation: a retrospective case series with 10 weeks of observations in 28 patients.
pmid: 39058351
abstract: This study investigated the effect of implant vertical positioning within alveolar ridge preservation (ARP) sites on implant stability quotient (ISQ) values, which were measured 10 weeks post-implantation.Patients who underwent ARP using collagenized deproteinized bovine bone mineral, followed by implant placement in the posterior area, were divided into 2 groups: the within-ARP group and the beyond-ARP group. In the within-ARP group, osteotomy and implant placement occurred within the ARP boundary. In contrast, in the beyond-ARP group, these procedures were performed beyond the ARP boundary, incorporating 3 mm of pristine bone at the implant's apex. Bone quality was assessed by tactile sense, and both insertion torque during implant surgery and ISQ values at 10 weeks post-implant surgery were measured. Multiple linear regression analysis and Pearson correlation analysis were used to explore the relationship between insertion torque and ISQ values.In total, 30 ARP sites in 28 patients were analyzed. There was no significant difference in bone quality, as determined by tactile sense, between the within-ARP and beyond-ARP groups. At the time of implant placement, the beyond-ARP group exhibited a higher insertion torque (33.33±13.39 Ncm) compared to the within-ARP group (17.08±11.17 Ncm). However, the ISQ values were similar between the 2 groups 10 weeks after implant placement. A positive correlation between insertion torque and ISQ values was confirmed at 10 weeks post-implant.The engagement of pristine bone may facilitate high insertion torque during the placement of implants in ARP sites. Nevertheless, by 10 weeks post-implantation, the ISQ values were found to be comparable, irrespective of the implant's position.
rights: Copyright © 2025. Korean Academy of Periodontology.
has PII: 54.e19
doi: 10.5051/jpis.2400800040
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Ko YC
      type: Person
      first name: Young-Chang
      last name: Ko
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
  slot:
    index: 2
    item: Koo KT
      type: Person
      first name: Ki-Tae
      last name: Koo
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
  slot:
    index: 3
    item: Li L
      type: Person
      first name: Ling
      last name: Li
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
  slot:
    index: 4
    item: Lee D
      type: Person
      first name: Dongseob
      last name: Lee
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.National Dental Care Center for Persons with Special Needs, Seoul National University Dental Hospital, Seoul, Korea.
  slot:
    index: 5
    item: Lee YM
      type: Person
      first name: Yong-Moo
      last name: Lee
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
  slot:
    index: 6
    item: Seol YJ
      type: Person
      first name: Yang-Jo
      last name: Seol
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
  slot:
    index: 7
    item: Kim TH
      type: Person
      first name: Tae-Hyung
      last name: Kim
      member of: Private Practice, Kim & Lee Dental Clinic, Seoul, Korea. kthrock@nate.com.
  slot:
    index: 8
    item: Lee J
      type: Person
      first name: Jungwon
      last name: Lee
      member of: Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, Korea. houy1980@snu.ac.kr.
created: 2024-7-26T12:46
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-7-26T10:33
ISSN: 2093-2278
has issn l: 2093-2278
issue: 1
has NLM journal title abbreviation: J Periodontal Implant Sci
publication name: Journal of periodontal & implant science
language: eng
has national library of medicine journal id: 101526931
derived from: NLM
starting page: 50
ending page: 61
has place of publication: Korea (South)
source: J Periodontal Implant Sci. 2025-02;55(1):50-61.
volume: 55

Effects of cannabinoid receptor activation on Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells in vitro.
pmid: 39058353
abstract: Periodontitis is an inflammatory disease that results in the loss of periodontal tissue. The endocannabinoid system has anti-inflammatory properties and displays considerable potential for tissue regeneration. In this study, we aimed to explore whether the activation of this system can alleviate or reverse the inflammatory phenotype of human periodontal ligament stem cells (hPDLSCs) induced by exposure to the inflammagen lipopolysaccharide (LPS).We investigated the effects of activating specific cannabinoid receptors (CB1 and CB2) on the inflammatory phenotype of LPS-stimulated hPDLSCs. The exogenous ligands WIN55,212-2 and JWH-133 were employed to target the cannabinoid receptors. We conducted a thorough assessment of cell proliferation, metabolic activity, and adipogenic, osteogenic, and chondrogenic differentiation potential. Additionally, we measured cytokine release using enzyme-linked immunosorbent assays.Exposure to Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) caused an increase in cell proliferation while decreasing metabolic activity. While this exposure did not influence adipogenic or chondrogenic differentiation, it did result in reduced osteogenesis. Additionally, LPS induced the release of interleukin (IL)-6, IL-8, and monocyte chemoattractant protein 1. Immunolabeling revealed the presence of CB1 and CB2 on the cellular membrane, with these receptors playing distinct roles in hPDLSCs. The CB1 agonist WIN55,212-2 was found to increase metabolic activity and promote adipogenic differentiation, whereas the CB2 agonist JWH-133 promoted cell proliferation and osteogenic differentiation. When hPDLSCs were co-exposed to Pg-LPS and CB ligands, JWH-133 slightly ameliorated the inhibition of osteogenic differentiation and suppressed the release of inflammatory cytokines.This study clarifies the effects of specific CB receptor activation on hPDLCs and the inflammatory phenotype. Stimulation of the endocannabinoid system through the manipulation of endogen[cell cut: 2148 characters, first 2000 kept]
rights: Copyright © 2025. Korean Academy of Periodontology.
has PII: 54.e21
doi: 10.5051/jpis.2303680184
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Leypold T
      type: Person
      first name: Tim
      last name: Leypold
      member of: Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Aachen, Germany. tleypold@ukaachen.de.
  slot:
    index: 2
    item: Herbsthofer A
      type: Person
      first name: Alix
      last name: Herbsthofer
      member of: Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Aachen, Germany.
  slot:
    index: 3
    item: Craveiro RB
      type: Person
      first name: Rogerio B
      last name: Craveiro
      member of: Department of Orthodontics, University Hospital RWTH Aachen, Aachen, Germany.
  slot:
    index: 4
    item: Wolf M
      type: Person
      first name: Michael
      last name: Wolf
      member of: Department of Orthodontics, University Hospital RWTH Aachen, Aachen, Germany.
  slot:
    index: 5
    item: Beier JP
      type: Person
      first name: Justus P
      last name: Beier
      member of: Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Aachen, Germany.
  slot:
    index: 6
    item: Ruhl T
      type: Person
      first name: Tim
      last name: Ruhl
      member of: Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Aachen, Germany.
created: 2024-7-26T12:46
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-7-26T10:33
ISSN: 2093-2278
has issn l: 2093-2278
issue: 1
has NLM journal title abbreviation: J Periodontal Implant Sci
publication name: Journal of periodontal & implant science
language: eng
has national library of medicine journal id: 101526931
derived from: NLM
starting page: 18
ending page: 34
has place of publication: Korea (South)
source: J Periodontal Implant Sci. 2025-02;55(1):18-34.
volume: 55

The relation between preoperative radiological sarcopenia and postoperative recovery of physical activity in older surgical cancer patients; an explorative study.
pmid: 39182320
abstract: To identify older surgical cancer patients at risk of decreased postoperative recovery of physical activity (PA), this study assesses whether preoperative radiological sarcopenia (RS) is associated with a decreased ability to return to baseline PA. RS was defined as decreased psoas muscle mass or -density by gender-specific cut-offs on CT-scans at level of vertebra L3. PA was assessed as steps/day measured with PA tracker and recovery of PA was defined as >90% of preoperative steps/day at 3 months postoperatively. Of 44 included patients aged 65 and over undergoing oncologic surgery, 18 patients (41%) showed RS. Seventeen patients (39%) returned to baseline PA, of which eight patients had RS (47%). RS was not associated with a return to baseline PA (OR: 1.38, 95%CI 0.39-4.92, p = 0.61). In this exploratory study, no association was found between preoperative RS and recovery of PA postoperatively.
rights: Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
has PII: S1279-7707(24)00432-9
doi: 10.1016/j.jnha.2024.100345
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Hendriks S
      type: Person
      first name: S
      last name: Hendriks
      member of: Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: s.hendriks@umcg.nl.
  slot:
    index: 2
    item: Huisman MG
      type: Person
      first name: M G
      last name: Huisman
      member of: Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
  slot:
    index: 3
    item: Weerink L
      type: Person
      first name: L
      last name: Weerink
      member of: Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  slot:
    index: 4
    item: Jonker LT
      type: Person
      first name: L T
      last name: Jonker
      member of: Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  slot:
    index: 5
    item: van Munster BC
      type: Person
      first name: B C
      last name: van Munster
      member of: Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
  slot:
    index: 6
    item: de Haan JJ
      type: Person
      first name: J J
      last name: de Haan
      member of: Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  slot:
    index: 7
    item: de Bock GH
      type: Person
      first name: G H
      last name: de Bock
      member of: Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  slot:
    index: 8
    item: van Leeuwen BL
      type: Person
      first name: B L
      last name: van Leeuwen
      member of: Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
created: 2024-8-26T12:39
date last updated: 2025-03-08
issued: 2024-10
dp: 2024 Oct
created: 2024-8-25T18:02
e ISSN: 1760-4788
has issn l: 1279-7707
issue: 10
has NLM journal title abbreviation: J Nutr Health Aging
publication name: The journal of nutrition, health & aging
language: eng
has national library of medicine journal id: 100893366
derived from: NLM
pg: 100345
has place of publication: France
has primary subject term: D009369Q000150Q000503Q000601
has primary subject term: D020127
has primary subject term: D055948Q000000981Q000209Q000503
has primary subject term: D014057Q000706
has primary subject term: D061725Q000706
has subject term: D006801
has subject term: D008297
has subject term: D000368
has subject term: D057234
has subject term: D011184
has subject term: D015444
has subject term: D016658Q000000981Q000503
has subject term: D018709
has subject term: D012680
has subject term: D016896
source: J Nutr Health Aging. 2024-10;28(10):100345.
volume: 28

Racial and Ethnic Disparities in Testing of Hepatitis C Virus-Exposed Children Across the United States.
pmid: 39171788
abstract: Despite rising hepatitis C virus (HCV) prevalence among pregnant individuals in the United States, HCV testing among exposed infants remains low. Although recent guidelines recommend early ribonucleic acid (RNA) testing for HCV-exposed children to help improve testing rates, national studies describing factors associated with HCV testing and the type of testing completed are lacking.In this retrospective national study, we characterized HCV testing and care among HCV-exposed infants born between 2010 and 2020 captured in the electronic health record-based TriNetX Research Network. We analyzed factors associated with appropriate HCV testing completion (negative or positive HCV RNA testing or negative HCV antibody testing at any age through study end in 2022) and with RNA compared with antibody testing using univariable and multivariable logistic regression with clustered standard errors by healthcare organization.Of 8516 HCV-exposed children, 45.8% completed any HCV testing and 42.1% completed appropriate testing (25% of whom had RNA testing only). A total of 182 (5.1% of appropriately tested children) had evidence of HCV infection. Of 104 treatment-eligible children, 14.4% were treated. Black (odds ratio [OR]: 0.38, 95% confidence interval [CI]: 0.26-0.55), Asian/Pacific Islander (OR: 0.06, 95% CI: 0.03-0.11), and Hispanic/Latinx (OR: 0.56, 95% CI: 0.36-0.88) children had lower odds of appropriate testing compared with White and non-Hispanic/Latinx children.Fewer than half of HCV-exposed children in this national sample were tested for HCV, with lower testing odds among Black, Asian/Pacific Islander, and Hispanic/Latinx children. Substantial work to increase testing and treatment and decrease disparities in testing among HCV-exposed children is needed to help reach US HCV elimination goals.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7738776
doi: 10.1093/jpids/piae082
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Epstein RL
      type: Person
      first name: Rachel L
      last name: Epstein
      member of: Department of Medicine, Section of Infectious Diseases, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.Department of Pediatrics, Section of Infectious Diseases, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  slot:
    index: 2
    item: Kurnellas A
      type: Person
      first name: Anna
      last name: Kurnellas
      member of: Boston University School of Public Health, Boston, Massachusetts, USA.
  slot:
    index: 3
    item: Munroe S
      type: Person
      first name: Sarah
      last name: Munroe
      member of: Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA.
  slot:
    index: 4
    item: Curtis MR
      type: Person
      first name: Megan R
      last name: Curtis
      member of: Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA.Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
  slot:
    index: 5
    item: Biondi B
      type: Person
      first name: Breanne
      last name: Biondi
      member of: Department of Health Law, Policy and Management, Boston University School of Public Health, Boston, Massachusetts, USA.
  slot:
    index: 6
    item: Wachman EM
      type: Person
      first name: Elisha M
      last name: Wachman
      member of: Department of Pediatrics, Section of Newborn Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
created: 2024-8-22T12:44
date last updated: 2025-03-09
issued: 2024-11-21
dp: 2024 Nov 21
created: 2024-8-22T08:03
e ISSN: 2048-7207
has issn l: 2048-7193
issue: Supplement_5
has NLM journal title abbreviation: J Pediatric Infect Dis Soc
publication name: Journal of the Pediatric Infectious Diseases Society
language: eng
has national library of medicine journal id: 101586049
derived from: NLM
starting page: S159
ending page: S165
has place of publication: England
has primary subject term: D054625
has primary subject term: D006526Q000175Q000208Q000453
has subject term: D002648
has subject term: D002675
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D008297
has subject term: D011247
has subject term: D005006
has subject term: D016174Q000235Q000276
has subject term: D018937Q000097
has subject term: D018445Q000517
has subject term: D011251Q000175
has subject term: D012189
has subject term: D012367Q000097
has subject term: D014481Q000453
has subject term: D044469
source: J Pediatric Infect Dis Soc. 2024-11-21;13(Supplement_5):S159-S165.
volume: 13

Early Life Origins of Neurodevelopmental Disabilities in the Boston Birth Cohort: Research findings and future directions.
pmid: 39184946
abstract: Neurodevelopmental disabilities (NDD) are a group of conditions with onset in early development period and is characterized by limitations in several functional domains. Autism spectrum disorder (ASD) and Attention-Deficit Hyperactivity Disorders (ADHD), the most common NDDs, have complex etiologies and possibly multiple pathways leading up to the manifestation of these disorders. Boston Birth Cohort (BBC) is a preterm enriched birth cohort, and over the years, researchers have used the BBC dataset to study a broad spectrum of early life protective and risk factors in the context of NDDs. Broadly, some of them include: 1) nutrition (e.g. maternal folate, vitamin B12, cord folate species, selenium), 2) metabolic factors (e.g. role of maternal diabetes, obesity, branched chain amino acids and other essential amino acids), 3) lipid metabolism (e.g. maternal cholesterol), 4) immune activation and/or systematic inflammation (including maternal immune activation, inflammation of the placenta, inflammatory markers, maternal antibiotic use and acetaminophen use), and 5) other factors associated with NDDs (e.g. maternal stress, sickle cell disease). The findings from these studies are discussed in this review. BBC studies have advanced the field of NDD in the following important ways: 1) generating evidence that sheds light on new exposures, 2) furthering the existing knowledge using better methodological approaches, 3) analyzing novel mechanistic pathways on already proven relationship, and 4) advancing knowledge on the under-studied minority population in the U.S. BBC researchers are involved in ongoing efforts to characterize NDD developmental trajectories across the life stages by integrating multi-omics data (genome, epigenome, and metabolome) to gain a deeper understanding of the molecular pathways by which early life factors drive or shape the developmental trajectories of NDDs.
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Raghavan R
      type: Person
      first name: Ramkripa
      last name: Raghavan
      member of: Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  slot:
    index: 2
    item: Wang X
      type: Person
      first name: Xiaobin
      last name: Wang
      member of: Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
created: 2024-8-26T12:42
date last updated: 2025-03-09
issued: 2024-03
dp: 2024 Mar
created: 2024-8-26T05:10
ISSN: 2563-9021
has issn l: 2563-9021
issue: 1
has NLM journal title abbreviation: Precis Nutr
publication name: Precision nutrition
language: eng
has national library of medicine journal id: 9918419162506676
derived from: NLM
has place of publication: Canada
source: Precis Nutr. 2024-03;3(1):.
volume: 3

Relative Value Unit (RVU) and Medicare Severity Diagnosis-related Group (MS-DRG) Reimbursement in Cervical Spinal Fusion: A 2011-2023 Trends Report.
pmid: 39194047
abstract: Level 3 retrospective database study.This study aims to compare work RVU (wRVU), practice expense RVU (peRVU), malpractice RVU (mpRVU), and inflation-adjusted facility price alongside MS-DRG relative weight length of stay (LOS) for cervical spine fusions between 2011 and 2023.Both RVU and MS-DRG reimbursement have been studied in various surgical subspecialties; however, little investigation has centered on cervical spine fusions. To the best of our knowledge, this is the first study to investigate trends in RVU and MS-DRG reimbursement in cervical spine fusion throughout the COVID-19 pandemic.Center for Medicaid and Medicare Services (CMS) physician fee schedule was queried between 2011 and 2023 for RVU and facility reimbursement using common single and multilevel anterior and posterior cervical fusion codes. RVU facility prices were inflation adjusted to 2023. MS-DRG reimbursement data from 2011 to 2022 were compiled for cervical spinal fusion procedures with major complication or comorbidity (MCC) 471, complication or comorbidity (CC) 472, and without CC/MCC 473. Compound annual growth rates (CAGRs), Mean Annual Change, and yearly percent changes were calculated.No changes in wRVU were seen for all cervical CPT codes; however, the CAGR of peRVU (-0.51%±0.60%) and mpRVU (0.69%±0.41%) demonstrated marginal fluctuations. Every CPT code displayed an inflation-adjusted facility price decrease (-2.18%±0.24%). When assessing MS-DRG, there were marginal changes in geometric mean LOS (0.17%±0.45%), arithmetic mean LOS (-0.15%±0.84%), and relative weight (1.09%±0.68%). Unlike RVU reimbursement, the yearly percent change differs between each MS-DRG code.Inflation-adjusted RVU reimbursement facility prices demonstrated a consistent decrease, while DRG code reimbursement stayed relatively consistent over the study period. This data may help surgeons and hospitals become cognizant of temporal variations in reimbursement patterns as it may affect their personal practice.Level I[cell cut: 2023 characters, first 2000 kept]
rights: Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 01933606-990000000-00348
doi: 10.1097/BSD.0000000000001660
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Asthana S
      type: Person
      first name: Shravan
      last name: Asthana
      member of: Department of Orthopedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
  slot:
    index: 2
    item: Bajaj PM
      type: Person
      first name: Pranav M
      last name: Bajaj
  slot:
    index: 3
    item: Staub JR
      type: Person
      first name: Jacob R
      last name: Staub
  slot:
    index: 4
    item: Workman CD
      type: Person
      first name: Connor D
      last name: Workman
  slot:
    index: 5
    item: Reyes SG
      type: Person
      first name: Samuel G
      last name: Reyes
  slot:
    index: 6
    item: Follett MA
      type: Person
      first name: Matthew A
      last name: Follett
  slot:
    index: 7
    item: Patel AA
      type: Person
      first name: Alpesh A
      last name: Patel
  slot:
    index: 8
    item: Hsu WK
      type: Person
      first name: Wellington K
      last name: Hsu
  slot:
    index: 9
    item: Divi SN
      type: Person
      first name: Srikanth N
      last name: Divi
created: 2024-8-28T12:42
date last updated: 2025-03-08
issued: 2025-03-01
dp: 2025 Mar 01
created: 2024-8-28T08:24
e ISSN: 2380-0194
has issn l: 2380-0186
issue: 2
has NLM journal title abbreviation: Clin Spine Surg
publication name: Clinical spine surgery
language: eng
has national library of medicine journal id: 101675083
derived from: NLM
starting page: E75
ending page: E80
has place of publication: United States
has primary subject term: D003953Q000191Q000639
has primary subject term: D013123Q000191Q000639
has primary subject term: D006278Q000191Q000639
has primary subject term: D015895
has primary subject term: D008318Q000191Q000639
has subject term: D012189
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000368
has subject term: D002574Q000601
has subject term: D014481Q000453
has subject term: D014487Q000706
has subject term: D005245Q000706
has subject term: D012720
has subject term: D000072161Q000191Q000331Q000639
source: Clin Spine Surg. 2025-03-01;38(2):E75-E80.
volume: 38

Developing a mouse model of human coronavirus NL63 infection: comparison with rhinovirus-A1B and effects of prior rhinovirus infection.
pmid: 39189801
abstract: Human coronavirus (HCoV)-NL63 causes respiratory tract infections in humans and uses angiotensin-converting enzyme 2 (ACE2) as a receptor. We sought to establish a mouse model of HCoV-NL63 and determine whether prior rhinovirus (RV)-A1B infection affected HCoV-NL63 replication. HCoV-NL63 was propagated in LLC-MK2 cells expressing human ACE2. RV-A1B was grown in HeLa-H1 cells. C57BL6/J or transgenic mice expressing human ACE2 were infected intranasally with sham LLC-MK2 cell supernatant or 1 × 105 tissue culture infectious dose (TCID50) units HCoV-NL63. Wild-type mice were infected with 1 × 106 plaque-forming units (PFU) RV-A1B. Lungs were assessed for vRNA, bronchoalveolar lavage (BAL) cells, histology, HCoV-NL63 nonstructural protein 3 (nsp3), and host gene expression by next-generation sequencing and qPCR. To evaluate sequential infections, mice were infected with RV-A1B followed by HCoV-NL63 infection 4 days later. We report that hACE2 mice infected with HCoV-NL63 showed evidence of replicative infection with increased levels of vRNA, BAL neutrophils and lymphocytes, peribronchial and perivascular infiltrates, and expression of nsp3. Viral replication peaked 3 days after infection and inflammation persisted 6 days after infection. HCoV-NL63-infected hACE2 mice showed increased mRNA expression of IFNs, IFN-stimulated proteins, and proinflammatory cytokines. Infection with RV-A1B 4 days before HCoV-NL63 significantly decreased both HCoV-NL63 vRNA levels and airway inflammation. Mice infected with RV-A1B prior to HCoV-NL63 showed increased expression of antiviral proteins compared with sham-treated mice. In conclusion, we established a mouse model of HCoV-NL63 replicative infection characterized by relatively persistent viral replication and inflammation. Prior infection with RV-A1B reduced HCoV-NL63 replication and airway inflammation, indicative of viral interference.NEW & NOTEWORTHY We describe a mouse model of human coronavirus (HCoV) infection. Infection of tra[cell cut: 2503 characters, first 2000 kept]
doi: 10.1152/ajplung.00149.2023
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Bentley JK
      type: Person
      first name: J Kelley
      last name: Bentley
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 2
    item: Kreger JE
      type: Person
      first name: Jordan E
      last name: Kreger
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 3
    item: Breckenridge HA
      type: Person
      first name: Haley A
      last name: Breckenridge
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 4
    item: Singh S
      type: Person
      first name: Shilpi
      last name: Singh
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 5
    item: Lei J
      type: Person
      first name: Jing
      last name: Lei
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 6
    item: Li Y
      type: Person
      first name: Yiran
      last name: Li
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 7
    item: Baker SC
      type: Person
      first name: Susan C
      last name: Baker
      member of: Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States.
  slot:
    index: 8
    item: Lumeng CN
      type: Person
      first name: Carey N
      last name: Lumeng
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.Department Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States.
  slot:
    index: 9
    item: Hershenson MB
      type: Person
      first name: Marc B
      last name: Hershenson
      member of: Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, United States.Department Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States.
created: 2024-8-27T12:45
date last updated: 2025-03-09
issued: 2024-10-01
dp: 2024 Oct 01
created: 2024-8-27T09:13
e ISSN: 1522-1504
has issn l: 1040-0605
issue: 4
has NLM journal title abbreviation: Am J Physiol Lung Cell Mol Physiol
publication name: American journal of physiology. Lung cellular and molecular physiology
language: eng
has national library of medicine journal id: 100901229
derived from: NLM
starting page: L557
ending page: L573
has place of publication: United States
has primary subject term: D058957Q000502
has primary subject term: D004195
has primary subject term: D012229Q000502Q000472
has primary subject term: D010850Q000821Q000378Q000473
has primary subject term: D000085962Q000378Q000235
has primary subject term: D008810
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D014779
has subject term: D018352Q000821Q000473Q000378
has subject term: D008822
has subject term: D008168Q000821Q000473Q000378
has subject term: D006367
has subject term: D001992Q000821
has subject term: D004770
source: Am J Physiol Lung Cell Mol Physiol. 2024-10-01;327(4):L557-L573.
volume: 327

World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines update - XVI - Nutritional management of cow's milk allergy.
pmid: 39228431
abstract: Cow's milk allergy (CMA) is one of the most common presentations of food allergy in early childhood. Management of CMA involves individualized avoidance of cow's milk and other mammalian milk and foods containing these. Optimal elimination of cow's milk avoidance includes: label reading; information about safe and nutritious substitute foods; appropriate choice of infant formula or a plant-based food; establishing tolerance to baked milk and monitoring nutritional intake and growth. Substitute formulas are divided into soy formula (not hydrolyzed), milk-based extensively hydrolyzed formulas, rice based extensive, and partially hydrolyzed formulas and amino acid-based formulas. The use of other mammalian milks is not recommended for the management of cow's milk allergy due to a high level of cross-reactivity and nutritional concerns. For toddlers who are eating well, children, and adults, a suitable plant-based beverage may be a suitable alternative to a specialized formula, following careful nutritional considerations. Families need to be instructed on finding suitable nutritious foods and how to prepare suitable meals at home. Individuals with CMA also need to know how to identify and treat acute severe reactions.
rights: © 2024 The Author(s).
has PII: S1939-4551(24)00062-0
doi: 10.1016/j.waojou.2024.100931
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Venter C
      type: Person
      first name: Carina
      last name: Venter
      member of: Section of Allergy and Immunology, University of Colorado Denver School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.
  slot:
    index: 2
    item: Meyer R
      type: Person
      first name: Rosan
      last name: Meyer
      member of: Department of Medicine, Imperial College, London. Department Medicine KU Leuven, Belgium. Department Nutrition and Dietetics, Winchester University, UK.
  slot:
    index: 3
    item: Groetch M
      type: Person
      first name: Marion
      last name: Groetch
      member of: Department of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai. New York, NY, USA.
  slot:
    index: 4
    item: Nowak-Wegrzyn A
      type: Person
      first name: Anna
      last name: Nowak-Wegrzyn
      member of: Department of Pediatrics, NYU Grossman School of Medicine, Hassenfeld Childrens' Hospital, New York, NY, USA.Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
  slot:
    index: 5
    item: Mennini M
      type: Person
      first name: Maurizio
      last name: Mennini
      member of: NESMOS Department, Sapienza University, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.
  slot:
    index: 6
    item: Pawankar R
      type: Person
      first name: Ruby
      last name: Pawankar
      member of: Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
  slot:
    index: 7
    item: Kamenwa R
      type: Person
      first name: Rose
      last name: Kamenwa
      member of: Department of Paediatrics and Child Health, Aga Khan University Hospital, Nairobi, Kenya.
  slot:
    index: 8
    item: Assa'ad A
      type: Person
      first name: Amal
      last name: Assa'ad
      member of: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center - Cincinnati Ohio, USA.
  slot:
    index: 9
    item: Amara S
      type: Person
      first name: Shriya
      last name: Amara
      member of: University of California, Los Angeles, USA.
  slot:
    index: 10
    item: Fiocchi A
      type: Person
      first name: Alessandro
      last name: Fiocchi
      member of: Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy.
  slot:
    index: 11
    item: Bognanni A
      type: Person
      first name: Antonio
      last name: Bognanni
      member of: Clinical Epidemiology and Research Center (CERC), Humanitas University & Humanitas Research Hospital, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele (Milano), Italy.Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.
creator: DRACMA Panel
created: 2024-9-4T06:42
date last updated: 2025-03-09
issued: 2024-08
dp: 2024 Aug
created: 2024-9-4T04:24
contributor: OrderedList
  length: 27
  slot:
    index: 1
    item: Ansotegui I
      type: Person
      first name: Ignacio
      last name: Ansotegui
      member of: Department of Allergy & Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
  slot:
    index: 2
    item: Arasi S
      type: Person
      first name: Stefania
      last name: Arasi
      member of: Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy.
  slot:
    index: 3
    item: Bahna SL
      type: Person
      first name: Sami L
      last name: Bahna
      member of: Allergy & Immunology Section, Louisiana State University Health Sciences Center - Shreveport, Louisiana, USA.
  slot:
    index: 4
    item: Canani RB
      type: Person
      first name: Roberto Berni
      last name: Canani
      member of: Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
  slot:
    index: 5
    item: Bozzola M
      type: Person
      first name: Martin
      last name: Bozzola
      member of: Department of Pediatrics, Section of Pediatric Allergy and Immunology. British Hospital. Buenos Aires, Argentina.
  slot:
    index: 6
    item: Brozek J
      type: Person
      first name: Jan
      last name: Brozek
      member of: McMaster's University, Hamilton, Ontario, Canada.
  slot:
    index: 7
    item: Chu D
      type: Person
      first name: Derek
      last name: Chu
      member of: McMaster's University, Hamilton, Ontario, Canada.
  slot:
    index: 8
    item: Dahdah L
      type: Person
      first name: Lamia
      last name: Dahdah
      member of: Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio, 4, Rome 00165, Italy.
  slot:
    index: 9
    item: Dupont C
      type: Person
      first name: Christophe
      last name: Dupont
      member of: Paris Descartes University, Pediatric Gastroenterology, Necker Hospital, Paris, Clinique Marcel Sembat, Boulogne-Billancourt, France.
  slot:
    index: 10
    item: Ebisawa M
      type: Person
      first name: Motohiro
      last name: Ebisawa
      member of: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.
  slot:
    index: 11
    item: Firmino RT
      type: Person
      first name: Ramon T
      last name: Firmino
      member of: Faculty of Medical Sciences of Campina Grande, UNIFACISA University Centre, Campina Grande, Paraiba, Brazil.
  slot:
    index: 12
    item: Galli E
      type: Person
      first name: Elena
      last name: Galli
      member of: Pediatric Allergy Unit, San Pietro Hospital - Fatebenefratelli, Rome, Italy.
  slot:
    index: 13
    item: Lack G
      type: Person
      first name: Gideon
      last name: Lack
      member of: Department of Woman and Childrens' Health/Peter Gorer Department of Immunobiology, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, UK.Evelina London Children's Hospital, Guy's St Thomas' Hospital, NHS Foundation Trust, London, UK.
  slot:
    index: 14
    item: Li H
      type: Person
      first name: Haiqi
      last name: Li
      member of: Department of Primary Child Care, Children's Hospital, Chongqing Medical University, China.
  slot:
    index: 15
    item: Martelli A
      type: Person
      first name: Alberto
      last name: Martelli
      member of: Allergist, Edmondo de Amicis School, Milan, Italy.
  slot:
    index: 16
    item: Papadopoulos NG
      type: Person
      first name: Nikolas G
      last name: Papadopoulos
      member of: Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.Allergy Unit, 2nd Paediatric Clinic, University of Athens, Athens, Greece.
ISSN: 1939-4551
has issn l: 1939-4551
issue: 8
has NLM journal title abbreviation: World Allergy Organ J
publication name: The World Allergy Organization journal
language: eng
has national library of medicine journal id: 101481283
derived from: NLM
pg: 100931
has place of publication: United States
source: World Allergy Organ J. 2024-08;17(8):100931.
volume: 17

A Review of the Indications, Outcomes, and Postoperative Management After Total and Completion Pancreatectomy for Pancreatic Cancer: More Is Not Necessarily Better.
pmid: 39237163
abstract: With improvements in surgical technique and advances in pancreatic endocrine and exocrine replacement therapy, the indications for, and threshold to perform, total or completion pancreatectomy in the modern surgical era are ever evolving. The following review will evaluate such indications for pancreatic cancer including pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasms. The authors also review the literature on oncologic outcomes of total and completion pancreatectomy for pancreatic cancer. Finally, they discuss the quality of life and postoperative management of the a-pancreatic state.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0039-6109(24)00067-7
doi: 10.1016/j.suc.2024.04.012
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Oppat KM
      type: Person
      first name: Kailey M
      last name: Oppat
      member of: Emory University, 1365B Clifton Road, NE Building B, Suite 4100, Office 4202, Atlanta, GA 30302, USA.
  slot:
    index: 2
    item: Bennett FJ
      type: Person
      first name: Frances J
      last name: Bennett
      member of: Emory University, 1365B Clifton Road, NE Building B, Suite 4100, Office 4202, Atlanta, GA 30302, USA.
  slot:
    index: 3
    item: Maithel SK
      type: Person
      first name: Shishir K
      last name: Maithel
      member of: Emory University, 1365B Clifton Road, NE Building B, Suite 4100, Office 4202, Atlanta, GA 30302, USA. Electronic address: smaithe@emory.edu.
created: 2024-9-6T01:02
date last updated: 2025-03-09
issued: 2024-10
dp: 2024 Oct
created: 2024-9-5T20:56
e ISSN: 1558-3171
has issn l: 0039-6109
issue: 5
has NLM journal title abbreviation: Surg Clin North Am
publication name: The Surgical clinics of North America
language: eng
has national library of medicine journal id: 0074243
derived from: NLM
starting page: 1049
ending page: 1064
has place of publication: United States
has primary subject term: D010180Q000379
has primary subject term: D010190Q000601
has subject term: D006801
has subject term: D011788
has subject term: D021441Q000601
has subject term: D011182Q000379
has subject term: D011183Q000453Q000209
has subject term: D016896
source: Surg Clin North Am. 2024-10;104(5):1049-1064.
volume: 104

Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees.
pmid: 39239461
abstract: Lifestyle has widespread effects on human health and aging. Prior results from chimpanzees (Pan troglodytes), one of humans' closest evolutionary relatives, indicate that these lifestyle effects may also be shared with other species, as semi-free-ranging chimpanzees fed a naturalistic diet show healthier values in several specific health biomarkers, compared with their sedentary, captive counterparts. Here, we examined how lifestyle factors associated with different environments affect rates of physiological aging in closely related chimpanzees.We compared physiological dysregulation, an index of biological aging, in semi-free-ranging chimpanzees in an African sanctuary versus captive chimpanzees in US laboratories. If the rate of aging is accelerated by high-calorie diet and sedentism, we predicted greater age-related dysregulation in the laboratory populations. Conversely, if costs of a wild lifestyle accelerate aging, then semi-free-ranging chimpanzees at the sanctuary, whose environment better approximates the wild, should show greater age-related dysregulation. We further tested whether dysregulation differed based on sex or body system, as in humans.We found that semi-free-ranging chimpanzees showed lower overall dysregulation, as well as lower age-related change in dysregulation, than laboratory chimpanzees. Males experienced lower dysregulation than females in both contexts, and the two populations exhibited distinct aging patterns based on body system.Our results support the conclusion that naturalistic living conditions result in healthier aging in chimpanzees. These data provide support for the proposal that lifestyle effects on human health and aging are conserved from deeper into our evolutionary history.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.
has PII: eoae010
doi: 10.1093/emph/eoae010
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Cole MF
      type: Person
      first name: Megan F
      last name: Cole
      member of: Department of Anthropology, University of New Mexico, Albuquerque, NM, USA.
  slot:
    index: 2
    item: Barnes P
      type: Person
      first name: Paige
      last name: Barnes
      member of: Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
  slot:
    index: 3
    item: Monroe IG
      type: Person
      first name: Isabelle G
      last name: Monroe
      member of: Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
  slot:
    index: 4
    item: Rukundo J
      type: Person
      first name: Joshua
      last name: Rukundo
      member of: Chimpanzee Sanctuary and Wildlife Conservation Trust, Entebbe, Uganda.
  slot:
    index: 5
    item: Emery Thompson M
      type: Person
      first name: Melissa
      last name: Emery Thompson
      member of: Department of Anthropology, University of New Mexico, Albuquerque, NM, USA.
  slot:
    index: 6
    item: Rosati AG
      type: Person
      first name: Alexandra G
      last name: Rosati
      member of: Department of Psychology, University of Michigan, Ann Arbor, MI, USA.Department of Anthropology, University of Michigan, Ann Arbor, MI, USA.
created: 2024-9-6T06:41
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-9-6T04:37
ISSN: 2050-6201
has issn l: 2050-6201
issue: 1
has NLM journal title abbreviation: Evol Med Public Health
publication name: Evolution, medicine, and public health
language: eng
has national library of medicine journal id: 101616698
derived from: NLM
starting page: 129
ending page: 142
has place of publication: England
source: Evol Med Public Health. 2024;12(1):129-142.
volume: 12

The Impact of Pregnancy Readiness on Lupus Activity, Maternal Mental Health, and Pregnancy Outcomes.
pmid: 39245944
abstract: Among individuals with systemic lupus erythematosus (SLE) who became pregnant, we explored the impact of medical readiness for pregnancy and personal readiness for pregnancy on the following aspects of maternal health: (1) provider-reported disease activity, (2) patient-perceived disease activity, (3) mood symptoms, (4) pregnancy-related health behaviors, and (5) pregnancy outcomes.All study participants were enrolled in a prospective registry, met Systemic Lupus Collaborating Clinics (SLICC) criteria for SLE, and had at least one pregnancy. Patient-reported outcomes were collected at the first rheumatology visit during pregnancy. Medically ready for pregnancy was defined as (1) <1 g of proteinuria, (2) no rheumatic teratogens at conception, and (3) continuing pregnancy-compatible SLE medications after conception. Personally ready was defined as planned pregnancy based on a London Measure of Unplanned Pregnancy score ≥10. Multivariable logistic regression models estimated the association of pregnancy readiness with each outcome of interest.Among the 111 individuals enrolled, lack of medical readiness for pregnancy was associated with significantly higher rates of active disease and worse pregnancy outcomes; however, these patients did not perceive themselves as having higher disease activity. Lack of personal readiness for pregnancy was associated with significantly higher patient-perceived disease activity. Although medical readiness did not impact depressive symptoms substantially, lack of personal readiness for pregnancy was associated with much higher maternal depressive symptoms.To improve pregnancy outcomes among individuals with SLE, greater focus is needed on improving medical optimization before conception. For maternal mental health and quality of life, greater focus is needed on decreasing the incidence of unplanned pregnancy.
rights: © 2024 American College of Rheumatology.
doi: 10.1002/acr.25430
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Harding CC
      type: Person
      first name: Ceshae C
      last name: Harding
      member of: Duke University School of Medicine, Durham, North Carolina.
  slot:
    index: 2
    item: Eudy AM
      type: Person
      first name: Amanda M
      last name: Eudy
      member of: Duke University School of Medicine, Durham, North Carolina.
  slot:
    index: 3
    item: Sims CA
      type: Person
      first name: Cathrine A
      last name: Sims
      member of: Duke University School of Medicine, Durham, North Carolina.
  slot:
    index: 4
    item: Edens C
      type: Person
      first name: Cuoghi
      last name: Edens
      member of: University of Chicago Medicine, Chicago, Illinois.
  slot:
    index: 5
    item: Birru Talabi M
      type: Person
      first name: Mehret
      last name: Birru Talabi
      member of: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  slot:
    index: 6
    item: Ramsey-Goldman R
      type: Person
      first name: Rosalind
      last name: Ramsey-Goldman
      member of: Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  slot:
    index: 7
    item: Neil L
      type: Person
      first name: Laura
      last name: Neil
      member of: Duke University School of Medicine, Durham, North Carolina.
  slot:
    index: 8
    item: Clowse MEB
      type: Person
      first name: Megan E B
      last name: Clowse
      member of: Duke University School of Medicine, Durham, North Carolina.
created: 2024-9-9T06:42
date last updated: 2025-03-09
issued: 2024-09-08
dp: 2024 Sep 08
created: 2024-9-9T01:42
e ISSN: 2151-4658
has issn l: 2151-464X
has NLM journal title abbreviation: Arthritis Care Res (Hoboken)
publication name: Arthritis care & research
language: eng
has national library of medicine journal id: 101518086
derived from: NLM
has place of publication: United States
source: Arthritis Care Res (Hoboken). 2024-09-08;():.

Endocrine therapy for early breast cancer in the era of oral selective estrogen receptor degraders: challenges and future perspectives.
pmid: 39246179
abstract: Growth and survival of hormone receptor positive breast cancer cells are dependent on circulating hormones (e.g., estrogen and progesterone). Endocrine therapy improved outcomes in both early and advanced hormone receptor positive breast cancer. These treatments include drugs with different mechanisms of action, namely selective estrogen receptor modulators (SERM), aromatase inhibitors, and selective estrogen receptor degraders (SERDs). SERDs represent estrogen receptor antagonists, favoring its degradation and thus interfering with proliferation genes transcription and activation. Fulvestrant is the first approved SERD, administered intramuscularly for treating advanced breast cancer.Oral SERDs have been tested to overcome the limitation of the intramuscular administration, and to increase SERD bioavailability. Recently, an oral SERD, Elacestrant, has been approved by the Food and Drug Administration (FDA) for patients carrying an ESR1 mutation. In fact, oral SERDs seem to be effective in tumors harboring ESR1 mutations, a well known mechanism of resistance to endocrine therapy (especially aromatase inhibitors).More recently, oral SERDs have been tested in patients with early hormone receptor positive breast cancer, although their impact on survival and in this curative setting compared to standard endocrine therapy still needs to be elucidated. The best timing and duration of SERD administration and specific biomarkers in (neo)adjuvant setting remain largely unknown.
rights: Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
has PII: 00001622-202411000-00002
doi: 10.1097/CCO.0000000000001085
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ascione L
      type: Person
      first name: Liliana
      last name: Ascione
      member of: Division of Early Drug Development for Innovative Therapies, European Institute of Oncology (IEO) IRCCS.Department of Oncology and Hematology (DIPO), University of Milan, Milan, Italy.
  slot:
    index: 2
    item: Castellano G
      type: Person
      first name: Grazia
      last name: Castellano
      member of: Division of Early Drug Development for Innovative Therapies, European Institute of Oncology (IEO) IRCCS.Department of Oncology and Hematology (DIPO), University of Milan, Milan, Italy.
  slot:
    index: 3
    item: Curigliano G
      type: Person
      first name: Giuseppe
      last name: Curigliano
      member of: Division of Early Drug Development for Innovative Therapies, European Institute of Oncology (IEO) IRCCS.Department of Oncology and Hematology (DIPO), University of Milan, Milan, Italy.
  slot:
    index: 4
    item: Zagami P
      type: Person
      first name: Paola
      last name: Zagami
      member of: Division of Early Drug Development for Innovative Therapies, European Institute of Oncology (IEO) IRCCS.Department of Oncology and Hematology (DIPO), University of Milan, Milan, Italy.
created: 2024-9-9T06:41
date last updated: 2025-03-08
issued: 2024-11-01
dp: 2024 Nov 01
created: 2024-9-9T04:13
e ISSN: 1531-703X
has issn l: 1040-8746
issue: 6
has NLM journal title abbreviation: Curr Opin Oncol
publication name: Current opinion in oncology
language: eng
has national library of medicine journal id: 9007265
derived from: NLM
starting page: 465
ending page: 473
has place of publication: United States
has primary subject term: D018931Q000494
has primary subject term: D001943Q000188Q000378
has primary subject term: D065171Q000494
has primary subject term: D020845Q000494
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D000284
has subject term: D047072Q000494
has subject term: D001682
has subject term: D000076722Q000639
has subject term: D000077267Q000494
has subject term: D002986
source: Curr Opin Oncol. 2024-11-01;36(6):465-473.
volume: 36

Identifying Artifacts from Large Library Docking.
pmid: 39255340
abstract: While large library docking has discovered potent ligands for multiple targets, as the libraries have grown the hit lists can become dominated by rare artifacts that cheat our scoring functions. Here, we investigate rescoring top-ranked docked molecules with orthogonal methods to identify these artifacts, exploring implicit solvent models and absolute binding free energy perturbation as cross-filters. In retrospective studies, this approach deprioritized high-ranking nonbinders for nine targets while leaving true ligands relatively unaffected. We tested the method prospectively against hits from docking against AmpC β-lactamase. We prioritized 128 high-ranking molecules for synthesis and testing, a mixture of 39 molecules flagged as likely cheaters and 89 that were plausible inhibitors. None of the predicted cheating compounds inhibited AmpC detectably, while 57% of the 89 plausible compounds did so. As our libraries continue to grow, deprioritizing docking artifacts by rescoring with orthogonal methods may find wide use.
doi: 10.1021/acs.jmedchem.4c01632
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Wu Y
      type: Person
      first name: Yujin
      last name: Wu
      member of: Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States.
  slot:
    index: 2
    item: Liu F
      type: Person
      first name: Fangyu
      last name: Liu
      member of: Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States.
  slot:
    index: 3
    item: Glenn I
      type: Person
      first name: Isabella
      last name: Glenn
      member of: Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States.
  slot:
    index: 4
    item: Fonseca-Valencia K
      type: Person
      first name: Karla
      last name: Fonseca-Valencia
      member of: Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States.
  slot:
    index: 5
    item: Paris L
      type: Person
      first name: Lu
      last name: Paris
      member of: Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States.
  slot:
    index: 6
    item: Xiong Y
      type: Person
      first name: Yuyue
      last name: Xiong
      member of: Schrödinger, Inc., 9868 Scranton Road, San Diego, California 92121, United States.
  slot:
    index: 7
    item: Jerome SV
      type: Person
      first name: Steven V
      last name: Jerome
      member of: Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
  slot:
    index: 8
    item: Brooks CL
      type: Person
      first name: Charles L
      last name: Brooks
      member of: Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109, United States.
  slot:
    index: 9
    item: Shoichet BK
      type: Person
      first name: Brian K
      last name: Shoichet
      member of: Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States.
created: 2024-9-10T18:41
date last updated: 2025-03-09
issued: 2024-09-26
dp: 2024 Sep 26
created: 2024-9-10T14:13
e ISSN: 1520-4804
has issn l: 0022-2623
issue: 18
has NLM journal title abbreviation: J Med Chem
publication name: Journal of medicinal chemistry
language: eng
has national library of medicine journal id: 9716531
derived from: NLM
starting page: 16796
ending page: 16806
has place of publication: United States
has primary subject term: D062105
has primary subject term: D001618Q000737Q000378
has primary subject term: D054852Q000737Q000378Q000494
has subject term: D008024
has subject term: D001426Q000737Q000378
has subject term: D016477
has subject term: D065093Q000737Q000494Q000138
source: J Med Chem. 2024-09-26;67(18):16796-16806.
volume: 67

Enlightening the toxinological dark matter of spider venom enzymes.
pmid: 39271930
abstract: Spiders produce highly adapted venoms featuring a complex mixture of biomolecules used mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a major focus of research and drug development, whereas venom enzymes have been largely neglected. Nevertheless, investigation of venom enzymes not only reveals insights into their biological functions, but also provides templates for future industrial applications. Here we compared spider venom enzymes validated at protein level contained in the VenomZone database and from all publicly available proteo-transcriptomic spider venom datasets. We assigned reported enzymes to cellular processes and known venom functions, including toxicity, prey pre-digestion, venom preservation, venom component activation, and spreading factors. Our study unveiled extensive discrepancy between public databases and publications with regard to enzyme coverage, which impedes the development of novel spider venom enzyme-based applications. Uncovering the previously unrecognized abundance and diversity of venom enzymes will open new avenues for spider venom biodiscovery.
rights: © 2024. The Author(s).
has PII: 10.1038/s44185-024-00058-2
doi: 10.1038/s44185-024-00058-2
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Dresler J
      type: Person
      first name: Josephine
      last name: Dresler
      member of: Animal Venomics Lab, Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Gießen, Germany. josephine.dresler@ime.fraunhofer.de.LOEWE Centre for Translational Biodiversity Genomics, Frankfurt a. M., Germany. josephine.dresler@ime.fraunhofer.de.
  slot:
    index: 2
    item: Herzig V
      type: Person
      first name: Volker
      last name: Herzig
      member of: Centre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD, Australia.School of Science, Technology and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
  slot:
    index: 3
    item: Vilcinskas A
      type: Person
      first name: Andreas
      last name: Vilcinskas
      member of: Animal Venomics Lab, Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Gießen, Germany.LOEWE Centre for Translational Biodiversity Genomics, Frankfurt a. M., Germany.Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Gießen, Germany.
  slot:
    index: 4
    item: Lüddecke T
      type: Person
      first name: Tim
      last name: Lüddecke
      member of: Animal Venomics Lab, Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Gießen, Germany. tim.lueddecke@ime.fraunhofer.de.LOEWE Centre for Translational Biodiversity Genomics, Frankfurt a. M., Germany. tim.lueddecke@ime.fraunhofer.de.
created: 2024-9-14T10:46
date last updated: 2025-03-09
issued: 2024-09-13
dp: 2024 Sep 13
created: 2024-9-13T23:41
e ISSN: 2731-4243
has issn l: 2731-4243
issue: 1
has NLM journal title abbreviation: NPJ Biodivers
publication name: npj biodiversity
language: eng
has national library of medicine journal id: 9918804277406676
derived from: NLM
pg: 25
has place of publication: England
source: NPJ Biodivers. 2024-09-13;3(1):25.
volume: 3

Contextualising samples: supporting reference genomes of European biodiversity through sample and associated metadata collection.
pmid: 39289524
abstract: The European Reference Genome Atlas (ERGA) consortium aims to generate a reference genome catalogue for all of Europe's eukaryotic biodiversity. The biological material underlying this mission, the specimens and their derived samples, are provided through ERGA's pan-European network. To demonstrate the community's capability and capacity to realise ERGA's ambitious mission, the ERGA Pilot project was initiated. In support of the ERGA Pilot effort to generate reference genomes for European biodiversity, the ERGA Sampling and Sample Processing committee (SSP) was formed by volunteer experts from ERGA's member base. SSP aims to aid participating researchers through (i) establishing standards for and collecting of sample/specimen metadata; (ii) prioritisation of species for genome sequencing; and (iii) development of taxon-specific collection guidelines including logistics support. SSP serves as the entry point for sample providers to the ERGA genomic resource production infrastructure and guarantees that ERGA's high-quality standards are upheld throughout sample collection and processing. With the volume of researchers, projects, consortia, and organisations with interests in genomics resources expanding, this manuscript shares important experiences and lessons learned during the development of standardised operational procedures and sample provider support. The manuscript details our experiences in incorporating the FAIR and CARE principles, species prioritisation, and workflow development, which could be useful to individuals as well as other initiatives.
rights: © 2024. The Author(s).
has PII: 10.1038/s44185-024-00053-7
doi: 10.1038/s44185-024-00053-7
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Böhne A
      type: Person
      first name: Astrid
      last name: Böhne
      member of: Leibniz Institute for the Analysis of Biodiversity Change, Museum Koenig Bonn, Centre for Molecular Biodiversity Research, Adenauerallee 127, 53113, Bonn, Germany. a.boehne@leibniz-lib.de.
  slot:
    index: 2
    item: Fernández R
      type: Person
      first name: Rosa
      last name: Fernández
      member of: Metazoa Phylogenomics Lab, Biodiversity Program, Institute of Evolutionary Biology (IBE, CSIC-UPF), Passeig maritim de la Barceloneta 37-49, 08003, Barcelona, Spain.
  slot:
    index: 3
    item: Leonard JA
      type: Person
      first name: Jennifer A
      last name: Leonard
      member of: Conservation and Evolutionary Genetics Group, Estación Biológica de Doñana (EBD-CSIC), Avda. Americo Vespucio 26, 41092, Sevilla, Spain.
  slot:
    index: 4
    item: McCartney AM
      type: Person
      first name: Ann M
      last name: McCartney
      member of: Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA.
  slot:
    index: 5
    item: McTaggart S
      type: Person
      first name: Seanna
      last name: McTaggart
      member of: Earlham Institute, Norwich Research Park, Norwich, Norfolk, NR4 7UZ, UK.
  slot:
    index: 6
    item: Melo-Ferreira J
      type: Person
      first name: José
      last name: Melo-Ferreira
      member of: CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade do Porto, 4485-661, Vairão, Portugal.Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, 4169-007, Porto, Portugal.BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vairão, 4485-661, Vairão, Portugal.
  slot:
    index: 7
    item: Monteiro R
      type: Person
      first name: Rita
      last name: Monteiro
      member of: Leibniz Institute for the Analysis of Biodiversity Change, Museum Koenig Bonn, Centre for Molecular Biodiversity Research, Adenauerallee 127, 53113, Bonn, Germany.
  slot:
    index: 8
    item: Oomen RA
      type: Person
      first name: Rebekah A
      last name: Oomen
      member of: Centre for Ecological & Evolutionary Synthesis, University of Oslo, Blindernveien 31, 0371, Oslo, Norway.Natural History Museum, University of Oslo, P.O. Box 1172, Blindern, 0318, Oslo, Norway.Centre for Coastal Research, University of Agder, Universitetsveien 25, 4630, Kristiansand, Norway.Department of Biological Sciences, University of New Brunswick Saint John, 100 Tucker Park Road, E2K5E2, Saint John, Canada.Tjärnö Marine Laboratory, University of Gothenburg, Hättebäcksvägen 7, Gothenburg, 45296, Sweden.
  slot:
    index: 9
    item: Vinnere Pettersson O
      type: Person
      first name: Olga
      last name: Vinnere Pettersson
      member of: Science for Life Laboratory - Sweden (SciLifeLab), National Genomics Infrastructure, Uppsala University, P.O. Box 815, SE-752 37, Uppsala, Sweden.
  slot:
    index: 10
    item: Struck TH
      type: Person
      first name: Torsten H
      last name: Struck
      member of: Natural History Museum, University of Oslo, P.O. Box 1172, Blindern, 0318, Oslo, Norway.
created: 2024-9-18T00:49
date last updated: 2025-03-09
issued: 2024-09-17
dp: 2024 Sep 17
created: 2024-9-17T23:38
e ISSN: 2731-4243
has issn l: 2731-4243
issue: 1
has NLM journal title abbreviation: NPJ Biodivers
publication name: npj biodiversity
language: eng
has national library of medicine journal id: 9918804277406676
derived from: NLM
pg: 26
has place of publication: England
source: NPJ Biodivers. 2024-09-17;3(1):26.
volume: 3

Sleep Disturbances in Autoimmune Neurological Diseases: Mechanisms, Clinical Characteristics, Assessment, and Treatment Strategies.
pmid: 39297918
abstract: Sleep disturbances are a hallmark feature of various autoimmune neurological diseases (AINDs). However, limited awareness of these sleep manifestations exists among clinicians. We provide a comprehensive overview of assessment methods, characteristic sleep disturbances, the impact of specific antibodies on sleep patterns, and treatment strategies for sleep disturbances in AINDs.Research advancements in sleep disturbances in autoimmune neurological disease focus primarily on four areas: mechanisms, clinical characteristics, assessment, and treatment. Regarding mechanisms, animal models for AINDs, particularly those involving specific antibodies like anti-NMDAR, anti-LGI1, and anti-IgLON5, have become more comprehensive. Recent advancements in animal models have led to the establishment of numerous models for AINDs; these models include a wide range of antibodies, including anti-NMDAR, anti-LGI1, and anti-IgLON5. Several studies using these models have revealed common mechanisms underlying sleep disturbances in these diseases. In terms of clinical characteristics, the identification of antibodies associated with recently discovered AINDs has expanded the spectrum of sleep disturbance symptoms observed compared to prior findings. A comprehensive evaluation system for the assessment of sleep disturbances has been established, including questionnaires, polysomnography, functional magnetic resonance imaging, and 18F-FDG PET/CT. Additionally, cardiopulmonary coupling shows promise as a novel assessment tool. Currently, no universally effective treatment exists for sleep disturbances in autoimmune neurological diseases, either through symptomatic treatment or immunosuppressive therapy. Further studies are needed to confirm the efficacy of new therapies and validate the benefits of existing treatments. Sleep disturbances are a hallmark feature of AINDs. Recent advancements have significantly expanded our understanding of their assessment and treatment. However, further studi[cell cut: 2085 characters, first 2000 kept]
rights: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s11910-024-01377-4
doi: 10.1007/s11910-024-01377-4
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Meng H
      type: Person
      first name: Huanyu
      last name: Meng
      member of: Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2 Road, Shanghai, 200025, China.Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
  slot:
    index: 2
    item: Chen X
      type: Person
      first name: Xiaoyu
      last name: Chen
      member of: Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2 Road, Shanghai, 200025, China.
  slot:
    index: 3
    item: Chen S
      type: Person
      first name: Sheng
      last name: Chen
      member of: Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2 Road, Shanghai, 200025, China. mztcs@163.com.Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China. mztcs@163.com.
created: 2024-9-21T13:19
date last updated: 2025-03-08
issued: 2024-12
dp: 2024 Dec
created: 2024-9-19T11:04
e ISSN: 1534-6293
has issn l: 1528-4042
issue: 12
has NLM journal title abbreviation: Curr Neurol Neurosci Rep
publication name: Current neurology and neuroscience reports
language: eng
has national library of medicine journal id: 100931790
derived from: NLM
starting page: 645
ending page: 663
has place of publication: United States
has primary subject term: D020274Q000150Q000276
has primary subject term: D012893Q000175Q000276
has primary subject term: D001323Q000276
has primary subject term: D003943
has primary subject term: D063189Q000379
has subject term: D017286
source: Curr Neurol Neurosci Rep. 2024-12;24(12):645-663.
volume: 24

Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.
pmid: 39307294
abstract: The abnormal expression of circRNA may contribute to the progression of cervical cancer by influencing the biological processes.This study aimed to identify the differentially expressed circRNAs in cervical cancer and validate the circ_0008193 ceRNA network in cervical cancer cells.Using the absolute log2 value of fold change >1 and p-value of <0.05, the differentially expressed circRNAs were obtained from GSE102686 and GSE113696 from cervical cancer tissues and cervical cancer cells with the help of the GEO2R tool. Downstream miRNAs and mRNAs were predicted using relevant informatics databases. The circRNA-miRNA-mRNA interaction network was conducted with the assistance of Cytoscape. Circ_0008193-miR-182-5p-PTEN axis was validated with expression level and cell function using RT-qPCR, a dual-luciferase reporter assay, and cellular experiments.GSE102686 and GSE113696 databases overlapped 7 differentially expressed circRNAs and five circRNAs have the same expression pattern. Based on the literature and expression pattern, a circRNA-miRNA-mRNA network was conducted. The circ_0008193, miR-182-5p, and PTEN expression patterns were downregulation, upregulation, and downregulation, respectively. Overexpressed circ_0008193 suppressed proliferation, migration, and invasion of cervical cancer cells. MiR-182-5p diminished the inhibitory influence of circ_0008193 on cellular behaviors, while PTEN counteracted the effect of miR-182-5p.This investigation revealed the existence of a circRNA-miRNA-mRNA network in cervical cancer, and preliminary verified the function of circ_0008193-miR-182-5p-PTEN axis in cervical cancer cells, which offers additional guidance on investigating the molecular mechanisms of cervical cancer.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S0890-8508(24)00036-7
doi: 10.1016/j.mcp.2024.101984
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Lou S
      type: Person
      first name: Shaosheng
      last name: Lou
      member of: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University/Key Laboratory of Molecular Biology of Endemic Diseases, Xinjiang, 830000, China. Electronic address: Loushaosheng20@163.com.
  slot:
    index: 2
    item: Yang W
      type: Person
      first name: Wang
      last name: Yang
      member of: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University/Key Laboratory of Molecular Biology of Endemic Diseases, Xinjiang, 830000, China.
  slot:
    index: 3
    item: Zhao Q
      type: Person
      first name: Qian
      last name: Zhao
      member of: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University/Key Laboratory of Molecular Biology of Endemic Diseases, Xinjiang, 830000, China.
  slot:
    index: 4
    item: Ouyang Y
      type: Person
      first name: Yunshan
      last name: Ouyang
      member of: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University/Key Laboratory of Molecular Biology of Endemic Diseases, Xinjiang, 830000, China.
  slot:
    index: 5
    item: Cao L
      type: Person
      first name: Lingling
      last name: Cao
      member of: Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University/Key Laboratory of Molecular Biology of Endemic Diseases, Xinjiang, 830000, China.
  slot:
    index: 6
    item: Lin C
      type: Person
      first name: Chen
      last name: Lin
      member of: Graduate School of Xinjiang Medical University, Xinjiang, 830000, China. Electronic address: linchenxj@163.com.
created: 2024-9-23T03:01
date last updated: 2025-03-08
issued: 2024-12
dp: 2024 Dec
created: 2024-9-22T19:25
e ISSN: 1096-1194
has issn l: 0890-8508
has NLM journal title abbreviation: Mol Cell Probes
publication name: Molecular and cellular probes
language: eng
has national library of medicine journal id: 8709751
derived from: NLM
pg: 101984
has place of publication: England
has primary subject term: D002583Q000235Q000473
has primary subject term: D000079962Q000235Q000378
has primary subject term: D035683Q000235Q000378
has primary subject term: D015972
has primary subject term: D053263
has primary subject term: D051059Q000235Q000378
has subject term: D006801
has subject term: D005260
has subject term: D045744
has subject term: D012333Q000235Q000378
has subject term: D049109Q000235
has subject term: D002465Q000235
has subject term: D020869
has subject term: http://id.nlm.nih.gov/mesh/D000095482
source: Mol Cell Probes. 2024-12;78():101984.
volume: 78

http://rdf.ncbi.nlm.nih.gov/pubmed/39310372
pmid: 39310372
abstract: Cow's milk allergy (CMA) is the most complex and common food allergy in infants. Elimination of cow's milk from the diet and replacement with a specialized formula for infants with cow's milk allergy who cannot be breastfed is an established approach to minimize the risk of severe allergic reactions while avoiding nutritional deficiencies. Given the availability of multiple options, such as extensively hydrolyzed cow's milk-based formula (eHF-CM), aminoacid formula (AAF), hydrolyzed rice formula (HRF), and soy formula (SF), there is some uncertainty regarding which formula might represent the most suitable choice with respect to health outcomes. The addition of probiotics to a specialized formula has also been proposed as a potential approach to possibly increase the benefit. We systematically reviewed specialized formulas for infants with CMA to inform the updated World Allergy Organization (WAO) DRACMA guidelines.To systematically review and synthesize the available evidence about the use of specialized formulas for the management of individuals with CMA.We searched from inception PubMed, Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and the websites of selected allergy organizations, for randomized and non-randomized trials of any language investigating specialized formulas with or without probiotics. We included all studies irrespective of the language of the original publication. The last search was conducted in January 2024. We synthesized the identified evidence quantitatively or narratively as appropriate and summarized it in the evidence profiles. We conducted this review following the PRISMA, Cochrane methods, and the GRADE approach.We identified 3558 records including 14 randomized trials and 7 observational studies. Very low certainty evidence suggested that in infants with IgE-mediated CMA, eHF-CM, compared with AAF, might have higher probability of outgrowing CMA (risk ratio (RR) 2.32; risk difference (RD) 25 more per 1[cell cut: 4356 characters, first 2000 kept]
rights: © 2024 The Author(s).
has PII: S1939-4551(24)00078-4
doi: 10.1016/j.waojou.2024.100947
creator: OrderedList
  length: 40
  slot:
    index: 1
    item: Bognanni A
      type: Person
      first name: Antonio
      last name: Bognanni
      member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Clinical Epidemiology and Research Center (CERC), Humanitas University & Humanitas Research Hospital, Pieve Emanuele, Milano, Italy.Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 2
    item: Firmino RT
      type: Person
      first name: Ramon T
      last name: Firmino
      member of: Academic Unit of Biological Sciences, Federal University of Campina Grande, Patos, Paraíba, Brazil.
  slot:
    index: 3
    item: Arasi S
      type: Person
      first name: Stefania
      last name: Arasi
      member of: Translational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  slot:
    index: 4
    item: Chu DK
      type: Person
      first name: Derek K
      last name: Chu
      member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 5
    item: Chu AWL
      type: Person
      first name: Alexandro W L
      last name: Chu
      member of: Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 6
    item: Waffenschmidt S
      type: Person
      first name: Siw
      last name: Waffenschmidt
      member of: Institute for Quality and Efficiency in Health Care, Cologne, Germany.
  slot:
    index: 7
    item: Agarwal A
      type: Person
      first name: Arnav
      last name: Agarwal
      member of: Department of Medicine, Division of Internal Medicine, McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 8
    item: Dziechciarz P
      type: Person
      first name: Piotr
      last name: Dziechciarz
      member of: Medical University of Warsaw, Warsaw, Poland.
  slot:
    index: 9
    item: Horvath A
      type: Person
      first name: Andrea
      last name: Horvath
      member of: Medical University of Warsaw, Warsaw, Poland.
  slot:
    index: 10
    item: Mihara H
      type: Person
      first name: Hanako
      last name: Mihara
      member of: Clinical Development Infectious Disease, Moderna Japan Co., Ltd., Japan.
  slot:
    index: 11
    item: Roldan Y
      type: Person
      first name: Yetiani
      last name: Roldan
      member of: McMaster University, Hamilton, Ontario, Canada.
  slot:
    index: 12
    item: Terracciano L
      type: Person
      first name: Luigi
      last name: Terracciano
      member of: Pediatric Primary Care, National Pediatric Health Care System, Milan, Italy.Italian Society of Preventive and Social Pediatrics (SIPPS), Italy.
  slot:
    index: 13
    item: Martelli A
      type: Person
      first name: Alberto
      last name: Martelli
      member of: Italian Society of Allergy and Pediatric Immunology (SIAIP), Italy.
  slot:
    index: 14
    item: Starok A
      type: Person
      first name: Anna
      last name: Starok
      member of: Evidence Prime Inc., Krakow, Poland.
  slot:
    index: 15
    item: Said M
      type: Person
      first name: Maria
      last name: Said
      member of: Allergy & Anaphylaxis Australia, Sydney, Australia.
  slot:
    index: 16
    item: Shamir R
      type: Person
      first name: Raanan
      last name: Shamir
      member of: Institute for Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Faculty of Medical and Health Sciences, Tel Aviv University, Israel.
  slot:
    index: 17
    item: Ansotegui IJ
      type: Person
      first name: Ignacio J
      last name: Ansotegui
      member of: Department of Allergy & Immunology, Hospital Quironsalud Bizkaia, Erandio, Bilbao, Spain.
  slot:
    index: 18
    item: Dahdah L
      type: Person
      first name: Lamia
      last name: Dahdah
      member of: Translational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  slot:
    index: 19
    item: Ebisawa M
      type: Person
      first name: Motohiro
      last name: Ebisawa
      member of: Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
  slot:
    index: 20
    item: Galli E
      type: Person
      first name: Elena
      last name: Galli
      member of: Pediatric Allergy Unit, Research Center, San Pietro Hospital - Fatebenefratelli, Rome, Italy.
  slot:
    index: 21
    item: Kamenwa R
      type: Person
      first name: Rose
      last name: Kamenwa
      member of: Department of Pediatrics and Child Health, Aga Khan University Hospital, Nairobi, Kenya.
  slot:
    index: 22
    item: Lack G
      type: Person
      first name: Gideon
      last name: Lack
      member of: Department of Women and Children's Health/Peter Gorer Department of Immunobiology, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, United Kingdom.Evelina London Children's Hospital, Guy's and St Thomas' Hospital NHS Foundation Trust, United Kingdom.
  slot:
    index: 23
    item: Li H
      type: Person
      first name: Haiqi
      last name: Li
      member of: Department of Primary Child Care, Children's Hospital, Chongqing Medical University, China.
  slot:
    index: 24
    item: Pawankar R
      type: Person
      first name: Ruby
      last name: Pawankar
      member of: Department of Pediatrics. Nippon Medical School, Tokyo, Japan.
  slot:
    index: 25
    item: Warner A
      type: Person
      first name: Amena
      last name: Warner
      member of: Allergy UK, Crayford, Kingdom, United Kingdom.
  slot:
    index: 26
    item: Wong GWK
      type: Person
      first name: Gary Wing Kin
      last name: Wong
      member of: Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
  slot:
    index: 27
    item: Bozzola M
      type: Person
      first name: Martin
      last name: Bozzola
      member of: Pediatric Allergy and Immunology Section, Dept of Pediatrics, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.
  slot:
    index: 28
    item: Assa'Ad A
      type: Person
      first name: Amal
      last name: Assa'Ad
      member of: Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
created: 2024-9-23T12:48
date last updated: 2025-03-09
issued: 2024-09
dp: 2024 Sep
created: 2024-9-23T06:01
ISSN: 1939-4551
has issn l: 1939-4551
issue: 9
has NLM journal title abbreviation: World Allergy Organ J
publication name: The World Allergy Organization journal
language: eng
has national library of medicine journal id: 101481283
derived from: NLM
pg: 100947
has place of publication: United States
source: World Allergy Organ J. 2024-09;17(9):100947.
title: World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update - XI - Milk supplement/replacement formulas for infants and toddlers with CMA - Systematic review.
volume: 17

A randomized controlled trial comparing brief online self-guided interventions for loneliness.
pmid: 39325409
abstract: Loneliness is a global health issue, but current loneliness interventions are not scalable enough to reach many who might benefit from them. Brief online interventions could greatly expand access to evidence-based loneliness interventions.We conducted a preregistered three-armed trial (N = 908, ages 16-78) to compare three self-guided online interventions: a single-session intervention (SSI) for loneliness, a 3-week, three-session intervention for loneliness, and an active control supportive therapy SSI (https://ClinicalTrials.gov, ID: NCT05687162).Loneliness decreased between baseline and Week 8 across all conditions (b = -5.80; d = -0.55; 95% CI [-0.62, -0.47]; p < .01), but did not decrease significantly more in those assigned to either the loneliness SSI (b = -1.27; d = -0.12; 95% CI [-0.30, 0.06]; p = .20) or the 3-week intervention (b = -0.93; d = -0.09; 95% CI [-0.27, 0.09]; p = .34) than those assigned to the control SSI. Participants found all three interventions acceptable but rated both loneliness interventions as more acceptable than the control (p < .01). Far more participants completed the 10-min control SSI (86.6%) and 20-min loneliness SSI (69.4%) than the 60-min 3-week intervention (14.9%).An SSI for loneliness was not significantly less effective than a longer loneliness intervention and had a much higher completion rate. Yet, against our hypotheses, neither loneliness intervention reduced loneliness more than an active control SSI did. Future work should aim to design more effective SSIs for loneliness and identify populations for which SSIs might be most helpful. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
has PII: 2025-28696-001
doi: 10.1037/ccp0000908
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Kaveladze BT
      type: Person
      first name: Benjamin T
      last name: Kaveladze
      member of: Department of Medical Social Sciences, Northwestern University.
  slot:
    index: 2
    item: Gastelum SF
      type: Person
      first name: Sara F
      last name: Gastelum
      member of: Department of Psychological Science, University of California, Irvine.
  slot:
    index: 3
    item: Ngo DC
      type: Person
      first name: Dong-Anh C
      last name: Ngo
      member of: Department of Psychological Science, University of California, Irvine.
  slot:
    index: 4
    item: Delacruz P
      type: Person
      first name: Paul
      last name: Delacruz
      member of: Department of Psychological Science, University of California, Irvine.
  slot:
    index: 5
    item: Cohen KA
      type: Person
      first name: Katherine A
      last name: Cohen
      member of: Department of Medical Social Sciences, Northwestern University.
  slot:
    index: 6
    item: Käll A
      type: Person
      first name: Anton
      last name: Käll
      member of: Department of Behavioural Sciences and Learning, Linkoping University.
  slot:
    index: 7
    item: Andersson G
      type: Person
      first name: Gerhard
      last name: Andersson
      member of: Department of Behavioural Sciences and Learning, Linkoping University.
  slot:
    index: 8
    item: Schleider JL
      type: Person
      first name: Jessica L
      last name: Schleider
      member of: Department of Medical Social Sciences, Northwestern University.
  slot:
    index: 9
    item: Schueller SM
      type: Person
      first name: Stephen M
      last name: Schueller
      member of: Department of Psychological Science, University of California, Irvine.
created: 2024-9-26T12:42
date last updated: 2025-03-09
issued: 2025-01
dp: 2025 Jan
created: 2024-9-26T11:23
e ISSN: 1939-2117
has issn l: 0022-006X
issue: 1
has NLM journal title abbreviation: J Consult Clin Psychol
publication name: Journal of consulting and clinical psychology
language: eng
has national library of medicine journal id: 0136553
derived from: NLM
starting page: 54
ending page: 63
has place of publication: United States
has primary subject term: D008132Q000523
has primary subject term: http://id.nlm.nih.gov/mesh/D000079382
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000328
has subject term: D008875
has subject term: D000293
has subject term: D000368
has subject term: D055815
has subject term: D016896
source: J Consult Clin Psychol. 2025-01;93(1):54-63.
volume: 93

The Precision of Colour Doppler Ultrasonography Combined with Dynamic Infrared Thermography in Perforator Mapping for Deep Inferior Epigastric Perforator Flap Breast Reconstruction.
pmid: 39338223
abstract: Background: Perforator mapping is a mandatory tool for the preoperative planning of a microsurgical free flap, especially in breast reconstruction. Numerous methods for mapping have been described. In this study, we investigate the combined use of Dynamic Infrared Thermography (DIRT) and Colour Doppler Ultrasonography (CDUS) only to see whether it can eliminate the need for Computed Tomography Angiography (CTA). Methods: A prospective study was conducted on 33 patients with deep inferior epigastric perforator (DIEP) flaps for breast reconstruction. DIRT, followed by CDUS and CTA, was performed preoperatively and perforators were confirmed intraoperatively. Results: From 135 hot spots found on DIRT, 123 perforators were confirmed by CDUS (91.11%). A total of 86.66% of the perforator vessels detected on CTA have their correspondent on DIRT, while 95.12% have their correspondent on CDUS. No statistically significant difference (p > 0.05) was found comparing DIRT vs. CTA and CDU vs. CTA. The average DIRT time was 121.54 s and CDUS 232.09 s. The mean sensitivity for DIRT was 95.72% and 93.16% for CDUS. Conclusion: DIRT combined with CDUS can precisely and efficiently identify suitable perforators without the need for CTA in DIEP breast reconstruction.
has PII: jpm14090969
doi: 10.3390/jpm14090969
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Orădan AV
      type: Person
      first name: Alex Victor
      last name: Orădan
      member of: Department of Surgery-Plastic and Reconstructive Surgery, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.Department of Plastic and Reconstructive Surgery, Clinical Rehabilitation Hospital, 400066 Cluj-Napoca, Romania.Department of Plastic and Reconstructive Surgery, Prof. Dr. I. Chiricuță Institute of Oncology, 400015 Cluj-Napoca, Romania.
  slot:
    index: 2
    item: Georgescu AV
      type: Person
      first name: Alexandru Valentin
      last name: Georgescu
      member of: Department of Surgery-Plastic and Reconstructive Surgery, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.Department of Plastic and Reconstructive Surgery, Clinical Rehabilitation Hospital, 400066 Cluj-Napoca, Romania.
  slot:
    index: 3
    item: Jolobai AN
      type: Person
      first name: Andrei Nicolae
      last name: Jolobai
      member of: Department of Plastic and Reconstructive Surgery, Prof. Dr. I. Chiricuță Institute of Oncology, 400015 Cluj-Napoca, Romania.
  slot:
    index: 4
    item: Pașca GI
      type: Person
      first name: Gina Iulia
      last name: Pașca
      member of: Department of Diagnostic Radiology, Prof. Dr. I. Chiricuță Institute of Oncology, 400015 Cluj-Napoca, Romania.
  slot:
    index: 5
    item: Corpodean AA
      type: Person
      first name: Alma Andreea
      last name: Corpodean
      member of: Department of Plastic and Reconstructive Surgery, Clinical Rehabilitation Hospital, 400066 Cluj-Napoca, Romania.
  slot:
    index: 6
    item: Juncan TP
      type: Person
      first name: Teodora Paula
      last name: Juncan
      member of: Department of Plastic and Reconstructive Surgery, First Surgical Clinic, Emergency County Hospital, 400006 Cluj-Napoca, Romania.
  slot:
    index: 7
    item: Ilie-Ene A
      type: Person
      first name: Alexandru
      last name: Ilie-Ene
      member of: Department of Surgery, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  slot:
    index: 8
    item: Muntean MV
      type: Person
      first name: Maximilian Vlad
      last name: Muntean
      member of: Department of Surgery-Plastic and Reconstructive Surgery, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.Department of Plastic and Reconstructive Surgery, Prof. Dr. I. Chiricuță Institute of Oncology, 400015 Cluj-Napoca, Romania.
created: 2024-9-28T22:44
date last updated: 2025-03-09
issued: 2024-09-13
dp: 2024 Sep 13
created: 2024-9-28T01:21
ISSN: 2075-4426
has issn l: 2075-4426
issue: 9
has NLM journal title abbreviation: J Pers Med
publication name: Journal of personalized medicine
language: eng
has national library of medicine journal id: 101602269
derived from: NLM
has place of publication: Switzerland
source: J Pers Med. 2024-09-13;14(9):.
volume: 14

Heterogeneity Analysis on Multi-state Brain Functional Connectivity and Adolescent Neurocognition.
pmid: 39371422
abstract: Brain functional connectivity or connectome, a unique measure for brain functional organization, provides a great potential to explain the neurobiological underpinning of behavioral profiles. Existing connectome-based analyses highly concentrate on brain activities under a single cognitive state, and fail to consider heterogeneity when attempting to characterize brain-to-behavior relationships. In this work, we study the complex impact of multi-state functional connectivity on behaviors by analyzing the data from a recent landmark brain development and child health study. We propose a nonparametric, Bayesian supervised heterogeneity analysis to uncover neurodevelopmental subtypes with distinct effect mechanisms. We impose stochastic block structures to identify network-based functional phenotypes and develop a variational expectation-maximization algorithm to facilitate an efficient posterior computation. Through integrating resting-state and task-related functional connectomes, we dissect heterogeneous effect mechanisms on children's fluid intelligence from the functional network phenotypes including Fronto-parietal Network and Default Mode Network under different cognitive states. Based on extensive simulations, we further confirm the superior performance of our method on uncovering brain-to-behavior relationships.
doi: 10.1080/01621459.2024.2311363
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wang S
      type: Person
      first name: Shiying
      last name: Wang
      member of: Department of Biostatistics, Yale University, New Haven, CT.
  slot:
    index: 2
    item: Constable T
      type: Person
      first name: Todd
      last name: Constable
      member of: Department of Radiology & Biomedical Imaging, Yale University, New Haven, CT.
  slot:
    index: 3
    item: Zhang H
      type: Person
      first name: Heping
      last name: Zhang
      member of: Department of Biostatistics, Yale University, New Haven, CT.
  slot:
    index: 4
    item: Zhao Y
      type: Person
      first name: Yize
      last name: Zhao
      member of: Department of Biostatistics, Yale University, New Haven, CT.
created: 2024-10-7T11:22
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-10-7T05:25
ISSN: 0162-1459
has issn l: 0162-1459
issue: 546
has NLM journal title abbreviation: J Am Stat Assoc
publication name: Journal of the American Statistical Association
language: eng
has national library of medicine journal id: 01510020R
derived from: NLM
starting page: 851
ending page: 863
has place of publication: United States
source: J Am Stat Assoc. 2024;119(546):851-863.
volume: 119

Recombinant and Synthetic Affibodies Function Comparably for Modulating Protein Release.
pmid: 39372554
abstract: Affibodies are a class of versatile affinity proteins with a wide variety of therapeutic applications, ranging from contrast agents for imaging to cell-targeting therapeutics. We have identified several affibodies specific to bone morphogenetic protein-2 (BMP-2) with a range of binding affinities and demonstrated the ability to tune release rate of BMP-2 from affibody-conjugated poly(ethylene glycol) maleimide (PEG-mal) hydrogels based on affibody affinity strength. In this work, we compare the purity, structure, and activity of recombinant, bacterially-expressed BMP-2-specific affibodies with affibodies synthesized via solid-phase peptide synthesis.High- and low-affinity BMP-2-specific affibodies were recombinantly expressed using BL21(DE3) E. coli and chemically synthesized using microwave-assisted solid-phase peptide synthesis with Fmoc-Gly-Wang resin. The secondary structures of the affibodies and dissociation constants of affibody-BMP-2 binding were characterized by circular dichroism and biolayer interferometry, respectively. Endotoxin levels were measured using chromogenic limulus amebocyte lysate (LAL) assays. Affibody-conjugated PEG-mal hydrogels were fabricated and loaded with BMP-2 to evaluate hydrogel capacity for controlled release, quantified by enzyme-linked immunosorbent assays (ELISA).Synthetic and recombinant affibodies were determined to be α-helical by circular dichroism. The synthetic high- and low-affinity BMP-2-specific affibodies demonstrated comparable BMP-2 binding dissociation constants to their recombinant counterparts. Recombinant affibodies retained some endotoxins after purification, while endotoxins were not detected in the synthetic affibodies above FDA permissible limits. High-affinity affibody-conjugated hydrogels reduced cumulative BMP-2 release compared to the low-affinity affibody-conjugated hydrogels and hydrogels without affibodies.Synthetic affibodies demonstrate comparable structure and function to recombinant affibodies whi[cell cut: 2209 characters, first 2000 kept]
rights: © The Author(s) 2024.
has PII: 815
doi: 10.1007/s12195-024-00815-0
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Dorogin J
      type: Person
      first name: Jonathan
      last name: Dorogin
      member of: Department of Bioengineering, University of Oregon, Knight Campus, Eugene, Oregon USA.
  slot:
    index: 2
    item: Benz MA
      type: Person
      first name: Morrhyssey A
      last name: Benz
      member of: Department of Bioengineering, University of Oregon, Knight Campus, Eugene, Oregon USA.Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon USA.
  slot:
    index: 3
    item: Moore CJ
      type: Person
      first name: Cameron J
      last name: Moore
      member of: Department of Bioengineering, University of Oregon, Knight Campus, Eugene, Oregon USA.
  slot:
    index: 4
    item: Benoit DSW
      type: Person
      first name: Danielle S W
      last name: Benoit
      member of: Department of Bioengineering, University of Oregon, Knight Campus, Eugene, Oregon USA.
  slot:
    index: 5
    item: Hettiaratchi MH
      type: Person
      first name: Marian H
      last name: Hettiaratchi
      member of: Department of Bioengineering, University of Oregon, Knight Campus, Eugene, Oregon USA.Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon USA.
created: 2024-10-7T11:22
date last updated: 2025-03-09
issued: 2024-08
dp: 2024 Aug
created: 2024-10-7T05:58
ISSN: 1865-5025
has issn l: 1865-5025
issue: 4
has NLM journal title abbreviation: Cell Mol Bioeng
publication name: Cellular and molecular bioengineering
language: eng
has national library of medicine journal id: 101468590
derived from: NLM
starting page: 305
ending page: 312
has place of publication: United States
source: Cell Mol Bioeng. 2024-08;17(4):305-312.
volume: 17

Limited evidence for anatomical contacts between intestinal GLP-1 cells and vagal neurons in male mice.
pmid: 39390033
abstract: The communication between intestinal Glucagon like peptide 1 (GLP-1)-producing cells and the peripheral nervous system has garnered renewed interest considering the availability of anti-obesity and anti-diabetic approaches targeting GLP-1 signaling. While it is well-established that intestinal GLP-1 cells can exert influence through paracrine mechanisms, recent evidence suggests the possible existence of synaptic-like connections between GLP-1 cells and peripheral neurons, including those of the vagus nerve. In this study, using a reporter Phox2b-Cre-Tomato mouse model and super-resolution confocal microscopy, we demonstrated that vagal axons made apparent contacts with less than 0.5% of GLP-1 cells. Moreover, immunohistochemistry combined with super-resolution confocal microscopy revealed abundant post-synaptic density 95 (PSD-95) immunoreactivity within the enteric plexus of the lower intestines of C57/BL6 mice, with virtually none in its mucosa. Lastly, utilizing RNAScope in situ hybridization in the lower intestines of mice, we observed that GLP-1 cells expressed generic markers of secretory cells such as Snap25 and Nefm, but neither synaptic markers such as Syn1 and Nrxn2, nor glutamatergic markers such as Slc17a7. Through theoretical considerations and a critical review of the literature, we concluded that intestinal GLP-1 cells primarily communicate with vagal neurons through paracrine mechanisms, rather than synaptic-like contacts.
rights: © 2024. The Author(s).
has PII: 10.1038/s41598-024-74000-8
doi: 10.1038/s41598-024-74000-8
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Cao N
      type: Person
      first name: Newton
      last name: Cao
      member of: Department of Internal Medicine, Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  slot:
    index: 2
    item: Merchant W
      type: Person
      first name: Warda
      last name: Merchant
      member of: Department of Internal Medicine, Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  slot:
    index: 3
    item: Gautron L
      type: Person
      first name: Laurent
      last name: Gautron
      member of: Department of Internal Medicine, Center for Hypothalamic Research, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Laurent.Gautron@UTSouthwestern.edu.
created: 2024-10-11T00:34
date last updated: 2025-03-09
issued: 2024-10-10
dp: 2024 10 10
created: 2024-10-10T23:22
e ISSN: 2045-2322
has issn l: 2045-2322
issue: 1
has NLM journal title abbreviation: Sci Rep
publication name: Scientific reports
language: eng
has national library of medicine journal id: 101563288
derived from: NLM
pg: 23666
has place of publication: England
has primary subject term: D052216Q000378
has primary subject term: D009474Q000378
has primary subject term: D014630Q000378
has subject term: D000818
has subject term: D008297
has subject term: D051379
has subject term: D008810
source: Sci Rep. 2024-10-10;14(1):23666.
volume: 14

Novel Therapies for Primary Central Nervous System Lymphomas.
pmid: 39390309
abstract: Primary Central Nervous System Lymphoma (PCNSL) is an aggressive form of lymphoma that can involve the brain, spinal cord, leptomeninges and eyes. PCNSL prognosis continues to be poor, with 5-year survival rates of 30-40%. Therapeutic options are especially limited for relapsed/refractory (r/r) PCNSL. In recent years, studies shed light on the pathogenesis and oncogenic pathways driving PCNSL, leading to the development of novel therapeutics. In this review, we discuss the evidence supporting these novel agents and present ongoing clinical studies.Key oncogenic drivers of PCNSL include activation of the NFkB pathway, cell cycle dysregulation, somatic hypermutation and immune evasion, leading to the investigation of targeted therapeutics and immunotherapeutics to inhibit these pathways. Such approaches include BTK inhibitors, mTOR/PI3K inhibitors, immunomodulatory agents (IMIDs), immune checkpoint inhibitors and CD19-based CAR T-cells. The therapeutic repertoire for PCNSL is rapidly evolving, and a multi-modality approach including intensive chemotherapy regimens and novel therapies will likely be utilized in the future.
rights: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s11910-024-01376-5
doi: 10.1007/s11910-024-01376-5
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Aquilanti E
      type: Person
      first name: Elisa
      last name: Aquilanti
      member of: Center for Neuro Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
  slot:
    index: 2
    item: Herrity E
      type: Person
      first name: Elizabeth
      last name: Herrity
      member of: Department of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplantation Program, Princess Margaret Cancer Center, Toronto, ON, Canada.
  slot:
    index: 3
    item: Nayak L
      type: Person
      first name: Lakshmi
      last name: Nayak
      member of: Center for Neuro Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA. Lakshmi_Nayak@dfci.harvard.edu.
created: 2024-10-11T00:34
date last updated: 2025-03-08
issued: 2024-12
dp: 2024 Dec
created: 2024-10-10T23:40
e ISSN: 1534-6293
has issn l: 1528-4042
issue: 12
has NLM journal title abbreviation: Curr Neurol Neurosci Rep
publication name: Current neurology and neuroscience reports
language: eng
has national library of medicine journal id: 100931790
derived from: NLM
starting page: 621
ending page: 629
has place of publication: United States
has primary subject term: D016543Q000276Q000401Q000628
has primary subject term: D008223Q000276Q000401Q000628
has primary subject term: D000970Q000627
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000068456
has subject term: D015398Q000187Q000276
has subject term: D047428Q000627
has subject term: D000091369Q000627
has subject term: D000082082Q000627
has subject term: D016219Q000379
source: Curr Neurol Neurosci Rep. 2024-12;24(12):621-629.
volume: 24

Bone health in transgender assigned female at birth people: effects of gender-affirming hormone therapy and gonadectomy.
pmid: 39391880
abstract: Gender-affirming hormone therapy (GAHT) and gender-affirming surgery (GAS) may be desired by transgender and gender-diverse (TGD) individuals who want to affirm their gender identity. Testosterone is the basis of GAHT for transgender individuals assigned female at birth (AFAB), whereas GAS can involve hysterectomy, bilateral salpingectomy, bilateral oophorectomy (BO), thorax masculinization, and phalloplasty. Our study aimed to evaluate the effects of GAHT on the bone health of TGD AFAB individuals who have undergone or not undergone BO.This was a single-center, longitudinal study with retrospectively collected data. TGD AFAB GAHT-naïve individuals were enrolled and underwent dual-energy X-ray absorptiometry scans and laboratory tests (hormonal and bone metabolism parameters) at baseline and after 5 and 10 years of GAHT.Two hundred and forty-three TGD AFAB people were included in this study. Seventy-five subjects had completed data for 5 years and 19 subjects for 10 years of GAHT. At baseline, low bone density (Z-score < -2.0) was found in 2.5% (6/243) of subjects for lumbar spine (LS), whereas total hip (TH) and femoral neck (FN) Z-scores and laboratory tests were within the normal female range. After stratifying by physical activity, the physically active group showed significantly higher LS BMD and Z-scores (p ≤ 0.05). Five years after the start of GAHT, a significant reduction in LS (p ≤ 0.05), TH (p ≤ 0.001), and FN (p ≤ 0.01) Z-scores was detected. A significant reduction in the Z-scores of all three bone sites was observed only in the subgroup that had undergone BO. After 5 years of GAHT, estradiol levels were significantly decreased compared to those in baseline (p ≤ 0.001). Significantly higher estradiol levels were detected in the 5-year no-BO subgroup compared to those in the 5-year BO subgroup (p ≤ 0.001). A significant reduction in LS and TH Z-scores were observed after 10 years of GAHT. At this time, estradiol levels were significantly decreased compar[cell cut: 2254 characters, first 2000 kept]
rights: Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola.
doi: 10.3389/fendo.2024.1416121
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Sanna E
      type: Person
      first name: Elena
      last name: Sanna
      member of: Division of Gynecology and Human Reproduction Physiopatology, Istituito di Ricovero e Cura a Carattere Scientifico (Scientific Institute for Research, Hospitalization and Healthcare) (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  slot:
    index: 2
    item: Lami A
      type: Person
      first name: Alessandra
      last name: Lami
      member of: Division of Gynecology and Human Reproduction Physiopatology, Istituito di Ricovero e Cura a Carattere Scientifico (Scientific Institute for Research, Hospitalization and Healthcare) (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
  slot:
    index: 3
    item: Giacomelli G
      type: Person
      first name: Giulia
      last name: Giacomelli
      member of: Division of Gynecology and Human Reproduction Physiopatology, Istituito di Ricovero e Cura a Carattere Scientifico (Scientific Institute for Research, Hospitalization and Healthcare) (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  slot:
    index: 4
    item: Alvisi S
      type: Person
      first name: Stefania
      last name: Alvisi
      member of: Division of Gynecology and Human Reproduction Physiopatology, Istituito di Ricovero e Cura a Carattere Scientifico (Scientific Institute for Research, Hospitalization and Healthcare) (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
  slot:
    index: 5
    item: Paccapelo A
      type: Person
      first name: Alexandro
      last name: Paccapelo
      member of: Research and Innovation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  slot:
    index: 6
    item: Seracchioli R
      type: Person
      first name: Renato
      last name: Seracchioli
      member of: Division of Gynecology and Human Reproduction Physiopatology, Istituito di Ricovero e Cura a Carattere Scientifico (Scientific Institute for Research, Hospitalization and Healthcare) (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
  slot:
    index: 7
    item: Meriggiola MC
      type: Person
      first name: Maria Cristina
      last name: Meriggiola
      member of: Division of Gynecology and Human Reproduction Physiopatology, Istituito di Ricovero e Cura a Carattere Scientifico (Scientific Institute for Research, Hospitalization and Healthcare) (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
created: 2024-10-11T06:23
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-10-11T04:28
ISSN: 1664-2392
has issn l: 1664-2392
has NLM journal title abbreviation: Front Endocrinol (Lausanne)
publication name: Frontiers in endocrinology
language: eng
has national library of medicine journal id: 101555782
derived from: NLM
pg: 1416121
has place of publication: Switzerland
has primary subject term: D063106
has primary subject term: D015519Q000187
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D008297
has subject term: D012189
has subject term: D008137
has subject term: D057829Q000379
has subject term: D013739Q000097
has subject term: D015502
has subject term: D055815
has subject term: D020249
has subject term: D008875
has subject term: D014189Q000097
has subject term: D057830
source: Front Endocrinol (Lausanne). 2024;15():1416121.
volume: 15

Comment on dose-response relationship between awake prone-positioning duration and PaO2/FiO2 changes and risk of disease aggravation in patients with severe COVID-19.
pmid: 39394031
has PII: S1036-7314(24)00259-5
doi: 10.1016/j.aucc.2024.09.007
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Daungsupawong H
      type: Person
      first name: Hinpetch
      last name: Daungsupawong
      member of: Private Academic Consultant, Phonhong, Laos. Electronic address: hinpetchdaung@gmail.com.
  slot:
    index: 2
    item: Wiwanitkit V
      type: Person
      first name: Viroj
      last name: Wiwanitkit
      member of: Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University, Chennai, India.
created: 2024-10-12T13:18
date last updated: 2025-03-08
issued: 2025-03
dp: 2025 Mar
created: 2024-10-11T21:55
ISSN: 1036-7314
has issn l: 1036-7314
issue: 2
has NLM journal title abbreviation: Aust Crit Care
publication name: Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
language: eng
has national library of medicine journal id: 9207852
derived from: NLM
pg: 101122
has place of publication: Australia
source: Aust Crit Care. 2025-03;38(2):101122.
volume: 38

Causal effect estimation in survival analysis with high dimensional confounders.
pmid: 39400258
abstract: With the ever advancing of modern technologies, it has become increasingly common that the number of collected confounders exceeds the number of subjects in a data set. However, matching based methods for estimating causal treatment effect in their original forms are not capable of handling high-dimensional confounders, and their various modified versions lack statistical support and valid inference tools. In this article, we propose a new approach for estimating causal treatment effect, defined as the difference of the restricted mean survival time (RMST) under different treatments in high-dimensional setting for survival data. We combine the factor model and the sufficient dimension reduction techniques to construct propensity score and prognostic score. Based on these scores, we develop a kernel based doubly robust estimator of the RMST difference. We demonstrate its link to matching and establish the consistency and asymptotic normality of the estimator. We illustrate our method by analyzing a dataset from a study aimed at comparing the effects of two alternative treatments on the RMST of patients with diffuse large B cell lymphoma.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of The International Biometric Society.
has PII: 7821101
doi: 10.1093/biomtc/ujae110
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Jiang F
      type: Person
      first name: Fei
      last name: Jiang
      member of: Department of Epidemiology and Biostatistics, The University of California, San Francisco, CA 94143, United States.
  slot:
    index: 2
    item: Zhao G
      type: Person
      first name: Ge
      last name: Zhao
      member of: Department of Mathematics and Statistics, Portland State University, Portland, OR 97201, United States.
  slot:
    index: 3
    item: Rodriguez-Monguio R
      type: Person
      first name: Rosa
      last name: Rodriguez-Monguio
      member of: Department of Clinical Pharmacy and Medication Outcomes Center, University of California, San Francisco, CA 94143, United States.
  slot:
    index: 4
    item: Ma Y
      type: Person
      first name: Yanyuan
      last name: Ma
      member of: Department of Statistics, Pennsylvania State University, University Park, PA 16802, United States.
created: 2024-10-14T16:18
date last updated: 2025-03-09
issued: 2024-10-03
dp: 2024 Oct 03
created: 2024-10-14T09:53
e ISSN: 1541-0420
has issn l: 0006-341X
issue: 4
has NLM journal title abbreviation: Biometrics
publication name: Biometrics
language: eng
has national library of medicine journal id: 0370625
derived from: NLM
has place of publication: England
has primary subject term: D015984
has primary subject term: D057216
has primary subject term: D016403Q000401
has subject term: D006801
has subject term: D016019
has subject term: D015986
has subject term: D015233
has subject term: D001699Q000379
has subject term: D003198
has subject term: D003627
source: Biometrics. 2024-10-03;80(4):.
volume: 80

Recommendation for Clinical T Staging in Patients with Non-Small Cell Lung Cancer: Volumetric Measurement: A Retrospective Study from Turkey.
pmid: 39433483
abstract: Currently, clinical T staging in non-small cell lung cancer (NSCLC) is based on the largest radiological diameter observed on computed tomography (CT). Under this system, tumors with varying shapes-such as spherical, amorphous, or spiculated tumors- can be assigned the same T stage even with different volumes. We aimed to propose a 3-dimensional (3D) volumetric staging system for NSCLC as an alternative to diameter- based T staging and to conduct comparative survival analyses between these methods.We retrospectively analyzed data from patients who underwent surgery for pT1-4N0M0 primary NSCLC between January 2018 and May 2022. Digital Imaging and Communications in Medicine data from patient CT scans were uploaded to 3D Slicer software for volumetric tumor measurement. Using the paired samples t-test or the Wilcoxon test, we compared the expected tumor volumes, calculated by tumor diameter, with the actual volumes measured by 3D Slicer. Receiver operating characteristic analysis was employed to determine the cut-off value for tumor volume. Kaplan-Meier analysis was utilized to assess overall survival, while the log-rank method was applied to compare survival differences between groups. The significance of changes in T stage was evaluated using the marginal homogeneity test.The study included 136 patients. Significant differences were observed between expected and actual tumor volumes (p=0.01), and associated changes in T stage were also significant (p=0.04). The survival analysis performed using tumor volume (p=0.009) yielded superior results compared to that based on diameter (p=0.04) in paients with early tumor stage.T-factor staging based on tumor volume could represent an alternative staging method for NSCLC.
has PII: jcs.24.052
doi: 10.5090/jcs.24.052
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Sayan M
      type: Person
      first name: Muhammet
      last name: Sayan
      member of: Department of Thoracic Surgery, Gazi University School of Medicine, Ankara, Turkey.
  slot:
    index: 2
    item: Kankoc A
      type: Person
      first name: Aykut
      last name: Kankoc
      member of: Department of Thoracic Surgery, Gazi University School of Medicine, Ankara, Turkey.
  slot:
    index: 3
    item: Aslan MT
      type: Person
      first name: Muhammet Tarik
      last name: Aslan
      member of: Department of Thoracic Surgery, Gazi University School of Medicine, Ankara, Turkey.
  slot:
    index: 4
    item: Akarsu I
      type: Person
      first name: Irmak
      last name: Akarsu
      member of: Department of Thoracic Surgery, Gazi University School of Medicine, Ankara, Turkey.
  slot:
    index: 5
    item: Kurul İC
      type: Person
      first name: İsmail Cuneyt
      last name: Kurul
      member of: Department of Thoracic Surgery, Gazi University School of Medicine, Ankara, Turkey.
  slot:
    index: 6
    item: Celik A
      type: Person
      first name: Ali
      last name: Celik
      member of: Department of Thoracic Surgery, Gazi University School of Medicine, Ankara, Turkey.
created: 2024-10-22T04:57
date last updated: 2025-03-09
issued: 2025-03-05
dp: 2025 Mar 05
created: 2024-10-21T22:32
ISSN: 2765-1606
has issn l: 2765-1606
issue: 2
has NLM journal title abbreviation: J Chest Surg
publication name: Journal of chest surgery
language: eng
has national library of medicine journal id: 101775790
derived from: NLM
starting page: 51
ending page: 57
has place of publication: Korea (South)
source: J Chest Surg. 2025-03-05;58(2):51-57.
volume: 58

Mitigating Lipemia Interference in Anti-Xa Activity Measurement Through High-Speed Centrifugation.
pmid: 39433318
doi: 10.1111/ijlh.14393
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Herb A
      type: Person
      first name: Agathe
      last name: Herb
      member of: Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  slot:
    index: 2
    item: Ousteland C
      type: Person
      first name: Clément
      last name: Ousteland
      member of: Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  slot:
    index: 3
    item: Proch C
      type: Person
      first name: Cléo
      last name: Proch
      member of: Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  slot:
    index: 4
    item: Wimmer J
      type: Person
      first name: Jordan
      last name: Wimmer
      member of: Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  slot:
    index: 5
    item: Mauvieux L
      type: Person
      first name: Laurent
      last name: Mauvieux
      member of: Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.CNRS UPR3572, Immunologie, Immunopathologie & Chimie Thérapeutique (I2CT), Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France.
  slot:
    index: 6
    item: Sattler L
      type: Person
      first name: Laurent
      last name: Sattler
      member of: Laboratoire d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
created: 2024-10-22T00:21
date last updated: 2025-03-09
issued: 2025-04
dp: 2025 Apr
created: 2024-10-21T20:33
e ISSN: 1751-553X
has issn l: 1751-5521
issue: 2
has NLM journal title abbreviation: Int J Lab Hematol
publication name: International journal of laboratory hematology
language: eng
has national library of medicine journal id: 101300213
derived from: NLM
starting page: 336
ending page: 339
has place of publication: England
source: Int J Lab Hematol. 2025-04;47(2):336-339.
volume: 47

Immediate implant placement in the premolar maxillary area: a cone-beam computed tomography study.
pmid: 39439105
abstract: This research aimed to investigate potential factors associated with the risk of perforation of the labial bone plate, nasal floor, or maxillary sinus floor during immediate implant placement (IIP) in the maxillary premolar area, utilizing a cone-beam computed tomography (CBCT) virtual study.CBCT exams from 179 eligible participants, encompassing 716 teeth, were included. Implants were virtually positioned in 2 orientations: along the long axis of the tooth (the prosthetically-driven position) and in an optimal position relative to adjacent anatomical structures (the bone-driven position). Binary logistic regression analysis was employed to assess potential associations between perforation or invasion and various covariates, including sex, age, tooth region, the distance from the tooth apex to the nasal floor or maxillary sinus floor, the angle between the prosthetically- and bone-driven positions (implant-line A angle [ILAA]), and the labial concavity angle (LCA).The mean ILAA was 18.3°±8.0°, and the angle was significantly larger for the second premolar compared to the first premolar. The mean minimum implant length was 13.0±2.1 mm, with a bone anchorage of 4 mm. The incidence of perforation was 84.1% for the prosthetically-driven position and 40.5% for the bone-driven position. Factors associated with a higher risk of cortical bone wall perforation or invasion of the 2-mm safety margin from surrounding anatomical structures (in the bone-driven position) included female sex, older age, shorter distance from the tooth apex to the nasal cavity/maxillary sinus, and smaller LCA.A high prevalence of cortical bone wall perforation or invasion of the 2-mm safety margin is anticipated when performing IIP in the maxillary premolar region.
rights: Copyright © 2025. Korean Academy of Periodontology.
has PII: 54.e23
doi: 10.5051/jpis.2303580179
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Najm A
      type: Person
      first name: Ali
      last name: Najm
      member of: Faculty of Odontology, Malmö University, Malmö, Sweden.
  slot:
    index: 2
    item: Bihorac A
      type: Person
      first name: Amer
      last name: Bihorac
      member of: Faculty of Odontology, Malmö University, Malmö, Sweden.
  slot:
    index: 3
    item: de Carvalho Machado V
      type: Person
      first name: Vinícius
      last name: de Carvalho Machado
      member of: Slice Diagnóstico Volumétrico por Imagem, Belo Horizonte, Brazil.
  slot:
    index: 4
    item: Chrcanovic BR
      type: Person
      first name: Bruno Ramos
      last name: Chrcanovic
      member of: Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden. bruno.chrcanovic@mau.se.
created: 2024-10-23T10:18
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-10-23T01:13
ISSN: 2093-2278
has issn l: 2093-2278
issue: 1
has NLM journal title abbreviation: J Periodontal Implant Sci
publication name: Journal of periodontal & implant science
language: eng
has national library of medicine journal id: 101526931
derived from: NLM
starting page: 72
ending page: 84
has place of publication: Korea (South)
source: J Periodontal Implant Sci. 2025-02;55(1):72-84.
volume: 55

Endoscopic transpapillary gallbladder drainage using a novel sphincterotome.
pmid: 39438418
doi: 10.1111/den.14943
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ishikawa T
      type: Person
      first name: Takuya
      last name: Ishikawa
      member of: Nagoya University Graduate School of Medicine, Aichi, Japan.
  slot:
    index: 2
    item: Kumano R
      type: Person
      first name: Ryohei
      last name: Kumano
      member of: Nagoya University Graduate School of Medicine, Aichi, Japan.
  slot:
    index: 3
    item: Kawashima H
      type: Person
      first name: Hiroki
      last name: Kawashima
      member of: Nagoya University Graduate School of Medicine, Aichi, Japan.
created: 2024-10-23T00:21
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-10-22T23:17
e ISSN: 1443-1661
has issn l: 0915-5635
issue: 3
has NLM journal title abbreviation: Dig Endosc
publication name: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
language: eng
has national library of medicine journal id: 9101419
derived from: NLM
starting page: 297
ending page: 299
has place of publication: Australia
source: Dig Endosc. 2025-03;37(3):297-299.
volume: 37

Does defect configuration affect the outcomes of alveolar ridge preservation? An experimental in vivo study.
pmid: 39439106
abstract: The purpose of this study was to compare the bone healing potential of 1-, 2-, and 3-wall defects following alveolar ridge preservation (ARP) treatment, as well as to evaluate the efficacy of ARP as a treatment option for destructive sites.Three groups, characterized by 1-, 2-, and 3-wall defects, were randomly assigned to the maxillary second, third, and fourth premolars in each of 8 beagle dogs. Each defect was created at either the mesial or distal root site of the tooth, which was hemi-sectioned and extracted. The contralateral root was preserved to superimpose with the experimental site for histomorphometric analysis. For each site, either spontaneous healing (SH; control) or ARP (test intervention) was randomly applied. Each group was divided in half and underwent a healing period of either 4 or 12 weeks. The Mann-Whitney U test and Kruskal-Wallis test were used for histomorphometric analyses. Statistical significance was set at P<0.05.Qualitative analysis revealed a higher percentage of new bone in the apical area compared to the coronal area, regardless of defect type and healing period. In quantitative analysis, the 3-wall defect exhibited a significantly higher percentage of mineralization in the ARP group after 12 weeks of healing (ARP: 61.73%±7.52%; SH: 48.84%±3.06%; P=0.029). An increased percentage of mineralization was observed with a greater number of remaining bony walls, although this finding did not reach statistical significance.Within the limitations of this study, ARP treatment for compromised sockets appears to yield a higher percentage of mineralization compared to SH. Although the effectiveness of the remaining bony walls was limited, their presence appeared to improve the percentage of mineralization in ARP treatment.
rights: Copyright © 2025. Korean Academy of Periodontology.
has PII: 54.e24
doi: 10.5051/jpis.2401480074
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lee D
      type: Person
      first name: Dongseob
      last name: Lee
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.National Dental Care Center for Persons with Special Needs, Seoul National University Dental Hospital, Seoul, Korea.
  slot:
    index: 2
    item: Choi JU
      type: Person
      first name: Jin Uk
      last name: Choi
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
  slot:
    index: 3
    item: Ko YC
      type: Person
      first name: Young-Chang
      last name: Ko
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
  slot:
    index: 4
    item: Koo KT
      type: Person
      first name: Ki-Tae
      last name: Koo
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
  slot:
    index: 5
    item: Seol YJ
      type: Person
      first name: Yang-Jo
      last name: Seol
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.
  slot:
    index: 6
    item: Lee YM
      type: Person
      first name: Yong-Moo
      last name: Lee
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea. ymlee@snu.ac.kr.
  slot:
    index: 7
    item: Lee J
      type: Person
      first name: Jungwon
      last name: Lee
      member of: Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea.One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, Korea. houy1980@snu.ac.kr.
created: 2024-10-23T10:18
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-10-23T01:13
ISSN: 2093-2278
has issn l: 2093-2278
issue: 1
has NLM journal title abbreviation: J Periodontal Implant Sci
publication name: Journal of periodontal & implant science
language: eng
has national library of medicine journal id: 101526931
derived from: NLM
starting page: 35
ending page: 49
has place of publication: Korea (South)
source: J Periodontal Implant Sci. 2025-02;55(1):35-49.
volume: 55

Genetic Risk Scores for the Clinical Rheumatologist.
pmid: 39454094
abstract: The advent of genome-wide sequencing and large-scale genetic epidemiological studies has led to numerous opportunities for the application of genetics in clinical medicine. Leveraging this information toward the formation of clinically useful tools has been an ongoing research goal in this area. A genetic risk score (GRS) is a measure that attempts to estimate the cumulative contribution of established genetic risk factors toward an outcome of interest, taking into account the cumulative risk that each of these individual genetic risk factors conveys. The purpose of this perspective is to provide a systematic framework to evaluate a GRS for clinical application.Since the initial polygenic risk score methodology in 2007, there has been increasing GRS application across the medical literature. In rheumatology, this has included application to rheumatoid arthritis, gout, spondyloarthritis, lupus, and inflammatory arthritis.GRSs are particularly relevant to rheumatology, where common diseases have many complex genetic factors contributing to risk. Despite this, there is no widely accepted method for the critical application of a GRS, which can be a particular challenge for the clinical rheumatologist seeking to clinically apply GRSs. This review provides a framework by which the clinician may systematically evaluate a GRS.As genotyping becomes more accessible and cost-effective, it will become increasingly important to recognize the clinical applicability of GRSs and identify those of the highest utility for patient care. This framework for the evaluation of a GRS will also help ensure reliability among GRS research in rheumatology, thereby helping to advance the field.
rights: Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 00124743-990000000-00261
doi: 10.1097/RHU.0000000000002152
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wheeler AM
      type: Person
      first name: Austin M
      last name: Wheeler
      member of: From the University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE.
  slot:
    index: 2
    item: Riley TR
      type: Person
      first name: Thomas R
      last name: Riley
      member of: University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.
  slot:
    index: 3
    item: Merriman TR
      type: Person
      first name: Tony R
      last name: Merriman
      member of: University of Alabama at Birmingham, Birmingham, AL.
created: 2024-10-25T22:27
date last updated: 2025-03-09
issued: 2025-01-01
dp: 2025 Jan 01
created: 2024-10-25T15:23
e ISSN: 1536-7355
has issn l: 1076-1608
issue: 1
has NLM journal title abbreviation: J Clin Rheumatol
publication name: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
language: eng
has national library of medicine journal id: 9518034
derived from: NLM
starting page: 26
ending page: 32
has place of publication: United States
has primary subject term: D020022
has subject term: D006801
has subject term: D018570Q000379
has subject term: D012216Q000235
has subject term: D055106Q000379
has subject term: D012219Q000379
has subject term: D012307
has subject term: http://id.nlm.nih.gov/mesh/D000072140
has subject term: http://id.nlm.nih.gov/mesh/D000096442
source: J Clin Rheumatol. 2025-01-01;31(1):26-32.
volume: 31

Correlation between intestinal CRE colonization and consequent systemic infection in hospitalized patients in China.
pmid: 39472675
abstract: It is generally believed that Carbapenem-resistant Enterobacterales (CRE) colonization is primarily responsible for systemic infection in humans. However, there is no consensus on whether decolonization should be recommended in clinical practice. In China, the specific situation of CRE colonization and consequent systemic infection in hospitalized patients necessitates further exploration. We conducted a cohort study and analyzed various clinical characteristics of inpatients with intestinal CRE colonization. A risk prediction model for consequent CRE infection was established and externally validated. Our prediction model is freely available online at https://creinfection.shinyapps.io/dynnomapp/ . 839 intestinal CRE colonization samples from inpatients were included. 317 cases of intestinal CRE colonization were enrolled, 25.9% of whom developed systemic infections. The consequent CRE infection rates of Klebsiella pneumoniae and Escherichia coli were 27.0% and 32.3%. The departments at high risk for subsequent CRE infection were respiratory medicine, hematology, and intensive care unit. Secondary infection after intestinal CRE colonization in inpatients can significantly prolong the length of hospital stay (26 days vs. 33 days, P < 0.001), increase the total medical cost (144735.34￥ vs. 281852.34￥, P < 0.001), and has poor (85.11% vs. 52.44%, P < 0.001) efficacy and high mortality (5.96% vs. 18.29%, P = 0.001). Our study makes a significant contribution to comprehensively specify CRE infection, because these results can facilitate early identification of high-risk hospitalized patients, timely implementation to decolonize treatment interventions, ultimately achieve the goal of CRE nosocomial infection prevention and control.
rights: © 2024. The Author(s).
has PII: 10.1038/s41598-024-76261-9
doi: 10.1038/s41598-024-76261-9
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Xiao Y
      type: Person
      first name: Yuanyuan
      last name: Xiao
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.
  slot:
    index: 2
    item: Duan J
      type: Person
      first name: Juping
      last name: Duan
      member of: Changsha Hospital of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha, Hunan Province, China.
  slot:
    index: 3
    item: Tan C
      type: Person
      first name: Caixia
      last name: Tan
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.
  slot:
    index: 4
    item: Zou J
      type: Person
      first name: Ju
      last name: Zou
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.
  slot:
    index: 5
    item: Chen S
      type: Person
      first name: Siyao
      last name: Chen
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.
  slot:
    index: 6
    item: Liu T
      type: Person
      first name: Ting
      last name: Liu
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.
  slot:
    index: 7
    item: Zhang L
      type: Person
      first name: Lina
      last name: Zhang
      member of: National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  slot:
    index: 8
    item: Chen X
      type: Person
      first name: Xin
      last name: Chen
      member of: National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  slot:
    index: 9
    item: Xu Y
      type: Person
      first name: Yajing
      last name: Xu
      member of: National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  slot:
    index: 10
    item: Li Y
      type: Person
      first name: Yuanyuan
      last name: Li
      member of: National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China.Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
  slot:
    index: 11
    item: Wu A
      type: Person
      first name: Anhua
      last name: Wu
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. xywuanhua@csu.edu.cn.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China. xywuanhua@csu.edu.cn.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China. xywuanhua@csu.edu.cn.
  slot:
    index: 12
    item: Li C
      type: Person
      first name: Chunhui
      last name: Li
      member of: Department of Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. lichunhui@csu.edu.cn.Super drug-resistant Organism Infection Prevention and Control Research Center, Xiangya Hospital, Changsha, Hunan Province, China. lichunhui@csu.edu.cn.National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan Province, China. lichunhui@csu.edu.cn.
created: 2024-10-30T10:28
date last updated: 2025-03-09
issued: 2024-10-29
dp: 2024 10 29
created: 2024-10-30T00:46
e ISSN: 2045-2322
has issn l: 2045-2322
issue: 1
has NLM journal title abbreviation: Sci Rep
publication name: Scientific reports
language: eng
has national library of medicine journal id: 101563288
derived from: NLM
pg: 26017
has place of publication: England
has primary subject term: D000073182Q000302
has subject term: D006801
has subject term: D002681Q000453
has subject term: D008297
has subject term: D005260
has subject term: D008875
has subject term: D000368
has subject term: D004756Q000453Q000382
has subject term: D007422Q000382
has subject term: D006760
has subject term: D007711Q000302
has subject term: D003428Q000382Q000453
has subject term: D000328
has subject term: D004926Q000302
has subject term: D012307
has subject term: D000900Q000627Q000494
source: Sci Rep. 2024-10-29;14(1):26017.
volume: 14

Prospective associations between early adolescent reward functioning and later dimensions of psychopathology.
pmid: 39480331
abstract: Individual differences in reward functioning have been associated with numerous disorders in adolescence. Given relations with multiple forms of psychopathology, it is unclear whether these associations are disorder specific or reflective of shared variance across multiple disorders. In a sample of adolescents (N = 418), we examined associations between neural and self-reported indices of early reward functioning (age 12) with different levels of a hierarchical psychopathology model assessed later in adolescence (age 18). We examined whether prospective relationships between reward functioning are specific to individual disorders or better explained by transdiagnostic dimensions. We found modest results for prospective associations between reward indices and different dimensions of psychopathology, with most significant associations not surviving correction for multiple comparisons. We discuss the benefits and limitations of the modeling approach used to examine dimension-specific associations that future work can build on. Overall, more work is needed to better understand how reward functioning is specifically associated with different forms of and hierarchical levels of psychopathology. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2025-40884-006
doi: 10.1037/abn0000942
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Mattoni M
      type: Person
      first name: Matthew
      last name: Mattoni
      member of: Department of Psychology and Neuroscience, Temple University.
  slot:
    index: 2
    item: Pegg S
      type: Person
      first name: Samantha
      last name: Pegg
      member of: Department of Psychology and Human Development, Vanderbilt University.
  slot:
    index: 3
    item: Kujawa A
      type: Person
      first name: Autumn
      last name: Kujawa
      member of: Department of Psychology and Human Development, Vanderbilt University.
  slot:
    index: 4
    item: Klein DN
      type: Person
      first name: Daniel N
      last name: Klein
      member of: Department of Psychology, Stony Brook University.
  slot:
    index: 5
    item: Olino TM
      type: Person
      first name: Thomas M
      last name: Olino
      member of: Department of Psychology and Neuroscience, Temple University.
created: 2024-10-31T12:28
date last updated: 2025-03-09
issued: 2024-11
dp: 2024 Nov
created: 2024-10-31T11:24
e ISSN: 2769-755X
has issn l: 2769-7541
issue: 8
has NLM journal title abbreviation: J Psychopathol Clin Sci
publication name: Journal of psychopathology and clinical science
language: eng
has national library of medicine journal id: 9918351179206676
derived from: NLM
starting page: 630
ending page: 637
has place of publication: United States
has primary subject term: D012201
has primary subject term: D001523Q000523Q000453
has subject term: D006801
has subject term: D000293
has subject term: D005260
has subject term: D008297
has subject term: D002648
has subject term: D011446
has subject term: D011599
has subject term: D007206
source: J Psychopathol Clin Sci. 2024-11;133(8):630-637.
volume: 133

Three principles for the utility of simple tasks that assess elemental processes in parsing heterogeneity.
pmid: 39480337
abstract: As clinical psychological science and biological psychiatry push to assess, model, and integrate heterogeneity and individual differences, approaches leveraging computational modeling, translational methods, and dimensional approaches to psychopathology are increasingly useful in establishing brain-behavior relationships. The field is ultimately interested in complex human behavior, and disruptions in such behaviors can arise through many different pathways, leading to heterogeneity in etiology for seemingly similar presentations. Parsing this complexity may be enhanced using simple tasks-which we define as those assaying elemental processes that are the building blocks to complexity. Using eyeblink conditioning as one illustrative example, we propose that simple tasks assessing elemental processes can be leveraged by and enhance computational psychiatry and dimensional approaches in service of understanding heterogeneity in psychiatry, especially when these tasks meet three principles: (a) an extensively mapped circuit, (b) clear brain-behavior relationships, and (c) relevance to understanding etiological processes and/or treatment. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2025-40884-012
doi: 10.1037/abn0000908
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Moussa-Tooks AB
      type: Person
      first name: Alexandra B
      last name: Moussa-Tooks
      member of: Department of Psychological and Brain Sciences, Indiana University Bloomington.
  slot:
    index: 2
    item: Barch DM
      type: Person
      first name: Deanna M
      last name: Barch
      member of: Department of Psychological Science, Washington University in St. Louis.
  slot:
    index: 3
    item: Hetrick WP
      type: Person
      first name: William P
      last name: Hetrick
      member of: Department of Psychological and Brain Sciences, Indiana University Bloomington.
created: 2024-10-31T12:28
date last updated: 2025-03-09
issued: 2024-11
dp: 2024 Nov
created: 2024-10-31T11:24
e ISSN: 2769-755X
has issn l: 2769-7541
issue: 8
has NLM journal title abbreviation: J Psychopathol Clin Sci
publication name: Journal of psychopathology and clinical science
language: eng
has national library of medicine journal id: 9918351179206676
derived from: NLM
starting page: 690
ending page: 696
has place of publication: United States
has primary subject term: D001921Q000502
has subject term: D006801
has subject term: D001767Q000502
has subject term: D001523Q000175
source: J Psychopathol Clin Sci. 2024-11;133(8):690-696.
volume: 133

Zinc as a treatment modality for acute infectious diarrhea in children.
pmid: 39483042
has PII: cep.2024.00381
doi: 10.3345/cep.2024.00381
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Park JS
      type: Person
      first name: Ji Sook
      last name: Park
      member of: Department of Pediatrics, Gyeongsang National University Hospital, Jinju, Korea.Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea.Institute of Medical Science, Gyeongsang National University, Jinju, Korea.
created: 2024-11-1T06:21
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-1T03:56
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 223
ending page: 224
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):223-224.
volume: 68

Peroral digital cholangioscopy-assisted removal of a migrated biliary plastic stent using a novel small dilating balloon.
pmid: 39489719
doi: 10.1111/den.14950
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Hirakawa N
      type: Person
      first name: Noriyuki
      last name: Hirakawa
      member of: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
  slot:
    index: 2
    item: Mukai S
      type: Person
      first name: Shuntaro
      last name: Mukai
      member of: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
  slot:
    index: 3
    item: Itoi T
      type: Person
      first name: Takao
      last name: Itoi
      member of: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
created: 2024-11-4T00:31
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-3T23:02
e ISSN: 1443-1661
has issn l: 0915-5635
issue: 3
has NLM journal title abbreviation: Dig Endosc
publication name: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
language: eng
has national library of medicine journal id: 9101419
derived from: NLM
starting page: 306
ending page: 307
has place of publication: Australia
source: Dig Endosc. 2025-03;37(3):306-307.
volume: 37

Validation of the APOBEC3A-Mediated RNA Single Base Substitution Signature and Proposal of Novel APOBEC1, APOBEC3B, and APOBEC3G RNA Signatures.
pmid: 39510348
abstract: Mutational signature analysis gained significant attention for providing critical insights into the underlying mutational processes for various DNA single base substitution (SBS) signatures and their associations with different cancer types. Recently, RNA single base substitution (RNA-SBS) signatures were defined and described by decomposing RNA variants found in non-small cell lung cancer. Through statistical association, they attributed Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 3A (APOBEC3A) mutagenesis to the RNA-SBS2 signature. Here, we provide the first validation of an RNA-SBS mutational signature by decomposing novel exogenous and endogenous APOBEC3A RNA editing signatures into COSMICv3.4 RNA-SBS reference signatures. Additionally, we have identified novel RNA-SBS signatures for APOBEC1, APOBEC3B, and APOBEC3G.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S0022-2836(24)00484-4
doi: 10.1016/j.jmb.2024.168854
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Fixman B
      type: Person
      first name: Benjamin
      last name: Fixman
      member of: Molecular and Computational Biology, Departments of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  slot:
    index: 2
    item: Díaz-Gay M
      type: Person
      first name: Marcos
      last name: Díaz-Gay
      member of: Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
  slot:
    index: 3
    item: Qiu C
      type: Person
      first name: Connor
      last name: Qiu
      member of: Molecular and Computational Biology, Departments of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  slot:
    index: 4
    item: Margaryan T
      type: Person
      first name: Tamara
      last name: Margaryan
      member of: Molecular and Computational Biology, Departments of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  slot:
    index: 5
    item: Lee B
      type: Person
      first name: Brian
      last name: Lee
      member of: Molecular and Computational Biology, Departments of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  slot:
    index: 6
    item: Chen XS
      type: Person
      first name: Xiaojiang S
      last name: Chen
      member of: Molecular and Computational Biology, Departments of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; Genetic, Molecular and Cellular Biology Program, Keck School of Medicine, USA; Norris Comprehensive Cancer Center, USA; Center of Excellence in NanoBiophysics, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: xiaojiac@usc.edu.
created: 2024-11-13T13:52
date last updated: 2025-03-09
issued: 2024-12-15
dp: 2024 Dec 15
created: 2024-11-7T19:41
e ISSN: 1089-8638
has issn l: 0022-2836
issue: 24
has NLM journal title abbreviation: J Mol Biol
publication name: Journal of molecular biology
language: eng
has national library of medicine journal id: 2985088R
derived from: NLM
pg: 168854
has place of publication: Netherlands
has primary subject term: D003564Q000235Q000378
has primary subject term: D000071479Q000235Q000378
has primary subject term: D015778Q000235Q000378
has subject term: D006801
has subject term: D000071480Q000235Q000378
has subject term: D011506Q000235Q000378
has subject term: D012313Q000235Q000378
has subject term: D017393
has subject term: D009154
has subject term: D002289Q000235
has subject term: D001055Q000235Q000378
source: J Mol Biol. 2024-12-15;436(24):168854.
volume: 436

Adaptive augmented cubature Kalman filter/smoother for ECG denoising.
pmid: 39530048
abstract: Model-based Bayesian approaches have been widely applied in Electrocardiogram (ECG) signal processing, where their performances heavily rely on the accurate selection of model parameters, particularly the state and measurement noise covariance matrices. In this study, we introduce an adaptive augmented cubature Kalman filter/smoother (CKF/CKS) for ECG processing, which updates the noise covariance matrices at each time step to accommodate diverse noise types and input signal-to-noise ratios (SNRs). Additionally, we incorporate the dynamic time warping technique to enhance the filter's efficiency in the presence of heart rate variability. Furthermore, we propose a method to significantly reduce the computational complexity required for CKF/CKS implementation in ECG processing. The denoising performance of the proposed filter was compared to those of various nonlinear Kalman-based frameworks involving the Extended Kalman filter/smoother (EKF/EKS), the unscented Kalman filter/smoother (UKF/UKS), and the ensemble Kalman filter (EnKF) that was recently proposed for ECG enhancement. In this study, we conducted a comprehensive evaluation and comparison of the performance of various nonlinear Kalman-based frameworks for ECG signal processing, which have been proposed in recent years. Our assessment was carried out on multiple normal ECG segments extracted from different entries in the MIT-BIH Normal Sinus Rhythm Database (NSRDB). This database provides a diverse set of ECG recordings, allowing us to examine the filters' denoising capabilities across various scenarios. By comparing the performance of these filters on the same dataset, we aimed to provide a thorough analysis and identification of the most effective approach for ECG denoising. Two kinds of noises were introduced to such segments: 1-stationary white Gaussian noise and 2-non-stationary real muscle artifact noise. For evaluation, four comparable measures namely the SNR improvement, PRD, correlation coefficient an[cell cut: 2258 characters, first 2000 kept]
rights: © Korean Society of Medical and Biological Engineering 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 362
doi: 10.1007/s13534-024-00362-7
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Hesar HD
      type: Person
      first name: Hamed Danandeh
      last name: Hesar
      member of: Faculty of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran.
  slot:
    index: 2
    item: Hesar AD
      type: Person
      first name: Amin Danandeh
      last name: Hesar
      member of: Department of Electrical and Computer Engineering and Advanced Technologies, Urmia University, Urmia, Iran.
created: 2024-11-14T03:54
date last updated: 2025-03-09
issued: 2024-07
dp: 2024 Jul
created: 2024-11-12T04:12
e ISSN: 2093-985X
has issn l: 2093-9868
issue: 4
has NLM journal title abbreviation: Biomed Eng Lett
publication name: Biomedical engineering letters
language: eng
has national library of medicine journal id: 101567784
derived from: NLM
starting page: 689
ending page: 705
has place of publication: Germany
source: Biomed Eng Lett. 2024-07;14(4):689-705.
volume: 14

Histological ovarian features and hormonal determinations in assigned females at birth transgender individuals according to different testosterone preparations.
pmid: 39530121
abstract: Distinct androgen formulations have been used as gender-affirming hormone treatment, but little is known about the specific changes that may occur in the ovary depending on the testosterone preparation used. The study aims to evaluate the histological modifications of the ovarian tissue and the hormonal changes after gender-affirming surgery based on the testosterone preparation employed, such as testosterone cypionate or undecanoate.Unicenter transversal cohort study.Sixty transmasculine persons before and after gender-affirming surgery. A histological examination of the ovaries was conducted, including the follicular population and the characterization of the ovarian stroma. Hormonal status (testosterone, estradiol, FSH, and LH) were also assessed before and after the procedure.The median age of participants was similar between the two groups (27.9 vs. 26.7 years, p = 0.27). There were no differences in all hormonal determinations before gender-affirming surgery between the groups. After surgery, FSH levels increased significantly, especially in the testosterone undecanoate group compared to the cypionate group (72.3 vs. 38.3 U/L, p = 0.02), consistent with LH determinations (43.0 vs. 23.4 U/L, p = 0.02). However, no regimen modification was required for any individual. No statistical differences were observed in any parameter concerning the follicular population, nor were there any variances in the thickness of the tunica albuginea (p = 0.85) or the proportion of luteinized stromal cells. Nevertheless, there was a tendency toward increased luteinization in the testosterone cypionate group (88.2% vs. 76.9%, p > 0.05).In a cohort of transmasculine individuals using different androgen preparations, histological analysis of ovarian tissue revealed comparable findings. Both groups exhibited similar follicular populations and comparable modifications in stromal tissue. However, significant differences were observed in hormonal profiles, although no modification in test[cell cut: 2027 characters, first 2000 kept]
rights: Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau.
doi: 10.3389/fendo.2024.1458846
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Borrás A
      type: Person
      first name: Aina
      last name: Borrás
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Gynecology, Human Reproduction and Women's Health Group, Barcelona, Spain.
  slot:
    index: 2
    item: Barral Y
      type: Person
      first name: Yasmina
      last name: Barral
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.
  slot:
    index: 3
    item: Fabregues F
      type: Person
      first name: Francesc
      last name: Fabregues
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Gynecology, Human Reproduction and Women's Health Group, Barcelona, Spain.
  slot:
    index: 4
    item: Casals G
      type: Person
      first name: Gemma
      last name: Casals
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Gynecology, Human Reproduction and Women's Health Group, Barcelona, Spain.
  slot:
    index: 5
    item: Mora M
      type: Person
      first name: Mireia
      last name: Mora
      member of: Endocrinology and Nutrition Department, Hospital Clínic, Universitat de Barcelona, Centro de Investigación Biomédica en Red. Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain.
  slot:
    index: 6
    item: Orois A
      type: Person
      first name: Aida
      last name: Orois
      member of: Endocrinology and Nutrition Department, Hospital Clínic, Universitat de Barcelona, Centro de Investigación Biomédica en Red. Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain.
  slot:
    index: 7
    item: Méndez M
      type: Person
      first name: Marta
      last name: Méndez
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.
  slot:
    index: 8
    item: Saco A
      type: Person
      first name: Adela
      last name: Saco
      member of: Deparment of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
  slot:
    index: 9
    item: Goday A
      type: Person
      first name: Anna
      last name: Goday
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.
  slot:
    index: 10
    item: Manau D
      type: Person
      first name: Dolors
      last name: Manau
      member of: Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Gynecology, Human Reproduction and Women's Health Group, Barcelona, Spain.
created: 2024-11-13T13:51
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-11-12T04:13
ISSN: 1664-2392
has issn l: 1664-2392
has NLM journal title abbreviation: Front Endocrinol (Lausanne)
publication name: Frontiers in endocrinology
language: eng
has national library of medicine journal id: 101555782
derived from: NLM
pg: 1458846
has place of publication: Switzerland
has primary subject term: D013739Q000031Q000097
has primary subject term: D063106
has primary subject term: D010053Q000187Q000601Q000473
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D008297
has subject term: D055815
has subject term: D005640Q000097
has subject term: D015331
has subject term: D000728
has subject term: D007986Q000097
has subject term: D004958Q000097
has subject term: D014189Q000097
has subject term: D057829Q000379
has subject term: D057830
source: Front Endocrinol (Lausanne). 2024;15():1458846.
volume: 15

Hyperparathyroidism and the Hematologist.
pmid: 39530344
doi: 10.1002/ajh.27527
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Oun H
      type: Person
      first name: Hajer
      last name: Oun
      member of: Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK.
  slot:
    index: 2
    item: Harper K
      type: Person
      first name: Kirsteen
      last name: Harper
      member of: Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK.
  slot:
    index: 3
    item: Leach M
      type: Person
      first name: Mike
      last name: Leach
      member of: Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK.
  slot:
    index: 4
    item: Bain BJ
      type: Person
      first name: Barbara J
      last name: Bain
      member of: Centre for Haematology, Department of Immunology and Inflammation, St. Mary's Hospital Campus of Imperial College London School of Medicine, London, UK.
created: 2024-11-13T13:57
date last updated: 2025-03-09
issued: 2025-04
dp: 2025 Apr
created: 2024-11-12T06:23
e ISSN: 1096-8652
has issn l: 0361-8609
issue: 4
has NLM journal title abbreviation: Am J Hematol
publication name: American journal of hematology
language: eng
has national library of medicine journal id: 7610369
derived from: NLM
starting page: 685
ending page: 686
has place of publication: United States
source: Am J Hematol. 2025-04;100(4):685-686.
volume: 100

Outcome of pediatric inflammatory bowel disease in Asian children: a multinational 1-year follow-up study.
pmid: 39533716
abstract: Epidemiological data on pediatric inflammatory bowel disease (PIBD) have been reported in Asian countries. However, short-term follow-up data, especially in Southeast Asian countries, are limited.Analyze and compare the baseline and 1-year follow-up (1FU) data for PIBD in Asian children.The multinational network included patients with PIBD (aged <19 years) in 5 Asian countries (Malaysia, Philippines, Singapore, Sri Lanka, and Thailand). The diagnosis of PIBD requires gastrointestinal endoscopy. The patients' demographics, clinical information, disease- related outcomes, and treatment data at 1FU were collected.In 1995-2021, 368 patients were enrolled (Crohn disease [CD], 56.8%; ulcerative colitis [UC], 38%; and inflammatory bowel disease [IBD]-unclassified, 5.2%). At 1FU, symptoms including diarrhea, bloody stools, and nausea/vomiting subsided in <3%, while abdominal pain persisted in 10.5% of patients with CD and 7.1% of patients with UC. Assessment endoscopy was performed at 1FU in 38% of CD and 31% of UC cases, of which 21% and 23% showed mucosal healing, respectively. Oral prednisolone was administered to 55.3% of patients at diagnosis and 26.8% at 1FU, while infliximab was administered to 2.5% and 7.2% of patients at diagnosis and 1FU, respectively. Independent factors of 1-year clinical remission for CD were oral prednisolone (odds ratio [OR], 0.20; 95% confidence interval [CI], 0.06-0.68), antibiotic use (OR, 0.09; 95% CI, 0.01-0.54), and immunomodulator use (OR, 5.26; 95% CI, 1.52-18.22). A history of weight loss at diagnosis was the only independent risk factor of an IBD flare by 1FU (OR, 2.01; 95% CI, 1.12-3.63).The proportion of children with PIBD and abdominal pain at 1FU remained high. The rates of repeat endoscopy and infliximab use were suboptimal with high rates of systemic corticosteroid use. Quality improvement based on the aforementioned predictors may enhance PIBD care in this geographic region or similar settings.
has PII: cep.2024.01144
doi: 10.3345/cep.2024.01144
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Tanpowpong P
      type: Person
      first name: Pornthep
      last name: Tanpowpong
      member of: Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  slot:
    index: 2
    item: Treepongkaruna S
      type: Person
      first name: Suporn
      last name: Treepongkaruna
      member of: Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  slot:
    index: 3
    item: Huang JG
      type: Person
      first name: James Guoxian
      last name: Huang
      member of: Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  slot:
    index: 4
    item: Chew KS
      type: Person
      first name: Kee Seang
      last name: Chew
      member of: Department of Pediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
  slot:
    index: 5
    item: Mercado KSC
      type: Person
      first name: Karen Sophia Calixto
      last name: Mercado
      member of: Department of Pediatrics, Makati Medical Center, Manila, the Philippines.
  slot:
    index: 6
    item: Reodica A
      type: Person
      first name: Almida
      last name: Reodica
      member of: Department of Pediatrics, The Medical City, Manila, the Philippines.
  slot:
    index: 7
    item: Rajindrajith S
      type: Person
      first name: Shaman
      last name: Rajindrajith
      member of: Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  slot:
    index: 8
    item: Hathagoda W
      type: Person
      first name: Wathsala
      last name: Hathagoda
      member of: Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  slot:
    index: 9
    item: Wong YKY
      type: Person
      first name: Yoko Kin Yoke
      last name: Wong
      member of: Epidemiology, Singapore Clinical Research Institute, Singapore, Singapore.
  slot:
    index: 10
    item: Lee WS
      type: Person
      first name: Way Seah
      last name: Lee
      member of: Department of Pediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.Dr. Wu Lien Teh Center for Research in Communicable Disease, M Kandiah Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman, Selangor, Malaysia.
  slot:
    index: 11
    item: Aw MM
      type: Person
      first name: Marion Margaret
      last name: Aw
      member of: Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
created: 2024-11-13T13:49
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-13T01:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 247
ending page: 256
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):247-256.
volume: 68

Prednisolone impairs trabecular bone score changes in adolescents with 21-hydroxylase deficiency.
pmid: 39533718
abstract: Individuals with 21-hydroxylase deficiency (21OHD) require lifelong glucocorticoid (GC) therapy, which increases their risk of fragility fractures. However, fractures in GC-treated individuals can occur at normal bone mineral density (BMD) levels, suggesting an alteration in the bone microarchitecture.To evaluate trabecular bone microarchitecture and its changes in adolescents with 21OHD.We enrolled 38 adolescents with 21OHD for whom complete clinical data and baseline and follow-up lumbar spine BMD (LSBMD) measurements were available. The mean duration was 1.5±0.6 years. Trabecular bone score (TBS), an indirect measurement of bone microarchitecture, was analyzed using iNsight software version 3.0. Impaired BMD and TBS were defined as z scores ≤ -1.5.At baseline, participants (55% female; 68% salt- wasting type; mean age, 15.2±3.8 years; bone age, 17.5± 2.8 years; mean GC dose, 18.5±6.5 mg/m2/day) had the prevalence of impaired BMD and TBS of 5% and 18%, respectively. During follow-up, adolescents with 21OHD receiving prednisolone showed a lower annual percentage change in TBS than those who received hydrocortisone (P=0.028). A stepwise regression analysis showed that body mass index percentile (P<0.001) and testosterone concentration (P=0.002) were independent positive predictors of the baseline TBS z score, whereas prednisolone use was the only negative predictor of the annual percentage change in TBS (P=0.002).Adolescents with 21OHD have a high prevalence of impaired bone microarchitecture. Furthermore, prednisolone therapy is associated with impaired bone microarchitecture development, suggesting that hydrocortisone may better preserve bone microarchitecture and should be considered the first-line treatment for this population.
has PII: cep.2024.01060
doi: 10.3345/cep.2024.01060
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Wiromrat P
      type: Person
      first name: Pattara
      last name: Wiromrat
      member of: Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 2
    item: Raruenrom Y
      type: Person
      first name: Yutapong
      last name: Raruenrom
      member of: Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 3
    item: Namphaisan P
      type: Person
      first name: Phanpaphorn
      last name: Namphaisan
      member of: Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 4
    item: Wongsurawat N
      type: Person
      first name: Nantaporn
      last name: Wongsurawat
      member of: Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 5
    item: Panamonta O
      type: Person
      first name: Ouyporn
      last name: Panamonta
      member of: Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 6
    item: Pongchaiyakul C
      type: Person
      first name: Chatlert
      last name: Pongchaiyakul
      member of: Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
created: 2024-11-13T13:54
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-13T01:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 238
ending page: 246
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):238-246.
volume: 68

Practical concepts and strategies for early diagnosis and management of eosinophilic gastrointestinal disorders in East-Asian children.
pmid: 39533717
abstract: Eosinophilic gastrointestinal disorders (EGIDs) are emerging as significant concerns in the Korean pediatric population and transitioning from rare to more commonly diagnosed conditions. This review discusses the increasing prevalence of EGID among children and adolescents and highlights the complexities involved in its diagnosis and management. This review begins with a thorough examination of the diverse clinical presentations of EGIDs in Korean children, with a special focus on common gastrointestinal symptoms such as abdominal pain, diarrhea, and bloody stool. Additionally, we explored extraintestinal manifestations, including growth failure, malnutrition, and associated allergic comorbidities, highlighting their importance in the clinical landscape of EGIDs. Because of its subtle and overlapping symptoms with those of other gastrointestinal disorders, EGID is frequently underdiagnosed. Addressing this challenge requires maintaining a high index of suspicion and employing a comprehensive diagnostic approach to differentiating EGID from functional gastrointestinal disorders and other inflammatory or systemic diseases such as inflammatory bowel disease. The optimal management of EGID requires a collaborative multidisciplinary strategy that includes dietary management, regular monitoring, and tailored medical interventions. This review emphasizes the importance of proactive patient and caregiver education and regular follow-ups to improve long-term outcomes in affected children. Enhanced awareness among healthcare providers and better educational resources for families are critical for the early identification and effective management of EGID among pediatric patients.
has PII: cep.2024.01165
doi: 10.3345/cep.2024.01165
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Choe BH
      type: Person
      first name: Byung-Ho
      last name: Choe
      member of: Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
created: 2024-11-13T13:52
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-13T01:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 185
ending page: 198
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):185-198.
volume: 68

Knowledge, attitude, and practice regarding dengue vaccine: a baseline study of community members and health providers in Indonesia.
pmid: 39533719
abstract: Despite recent behavioral interventions aimed at reducing the burden of dengue, persistent unfavorable related behaviors in the Indonesian community suggest that vaccination could be effective. However, before this is implemented nationally, public perception and acceptance of the vaccine should be assessed in addition to health providers' points of view.This study aimed to assess the knowledge, attitudes, and practices (KAP) of community members and health providers in Indonesia.A cross-sectional survey was conducted in 6 districts of 3 Indonesian provinces. Respondents included both community members and health providers living within the territory of the selected primary health care centers. Pretested questionnaires were used to gather information on the sociodemographic characteristics and KAPs regarding dengue vaccines. An independent t test was performed to compare the mean KAP scores between community members and health providers, while a logistic regression analysis was used to identify the predictors in each domain.Only 18.5% of health providers possessed high knowledge of the dengue vaccine versus only 12.5% of community members. Approximately one-third of the health providers versus one-fourth of community members displayed a high to moderate score for attitudes about dengue vaccines. Dengue vaccination practices demonstrated a more favorable score for both health providers and community members at 59.1% and 41.1%, respectively. No individual sociodemographic characteristics were associated with KAPs; rather, only education was correlated with better dengue vaccination practices. We also found that good knowledge of dengue was the only factor associated with all domains.Our findings highlight the urgent need to deliver educational interventions to health providers and community members in Indonesia to improve their awareness of dengue vaccines.
has PII: cep.2024.00962
doi: 10.3345/cep.2024.00962
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Wahab A
      type: Person
      first name: Abdul
      last name: Wahab
      member of: Center for Child Health-PRO, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.Center for Reproductive Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.Department of Biostatistics, Epidemiology, and Population Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  slot:
    index: 2
    item: Laksanawati IS
      type: Person
      first name: Ida Safitri
      last name: Laksanawati
      member of: Center for Child Health-PRO, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.Department of Pediatrics, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  slot:
    index: 3
    item: Padmawati RS
      type: Person
      first name: Retna Siwi
      last name: Padmawati
      member of: Center for Child Health-PRO, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.Department of Health Behavior, Environment, and Social Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  slot:
    index: 4
    item: Mulyadi AWE
      type: Person
      first name: Asal Wahyuni Erlin
      last name: Mulyadi
      member of: Center for Child Health-PRO, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.Department of Public Administration, Faculty of Social and Political Science, Universitas Sebelas Maret, Yogyakarta, Indonesia.
  slot:
    index: 5
    item: Triadmajani W
      type: Person
      first name: Wahyu
      last name: Triadmajani
      member of: Center for Child Health-PRO, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  slot:
    index: 6
    item: Thobari JA
      type: Person
      first name: Jarir At
      last name: Thobari
      member of: Center for Child Health-PRO, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
created: 2024-11-13T13:47
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-13T01:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 228
ending page: 237
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):228-237.
volume: 68

The predetermined future: tackling South Korea's total fertility rate crisis.
pmid: 39533735
has PII: cep.2024.00871
doi: 10.3345/cep.2024.00871
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kim JK
      type: Person
      first name: Jin Kyu
      last name: Kim
      member of: Department of Pediatrics, Jeonbuk National University School of Medicine, Jeonju, Korea.Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
created: 2024-11-13T13:59
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-13T01:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 225
ending page: 227
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):225-227.
volume: 68

Deep learning-driven ultrasound equipment quality assessment with ATS-539 phantom data.
pmid: 39541619
abstract: Ultrasound equipment provides real-time visualization of internal organs, essential for early disease detection and diagnosis. However, poor-quality ultrasound images can compromise diagnostic accuracy and increase the risk of misdiagnosis. Quality assessments are often subjective, relying on the evaluator's experience and interpretation, which can vary.This study introduces a two-stage deep learning framework designed to objectively assess ultrasound image quality using phantom data across three key parameters: 'Dead zone', 'Axial/lateral resolution', and 'Gray scale and dynamic range'. Stage 1 automatically extracts regions of interest for each parameter, while Stage 2 employs detection or classification models to evaluate image quality within these regions. To generate an overall equipment quality score, a logistic regression model combines the weighted results from each parameter.The classification model demonstrated high performance across datasets, achieving AUC scores of 98.6% for 'Dead zone', 87.7% for 'Axial/lateral resolution', and 96.0% for 'Gray scale and dynamic range'. Further analysis using guideline-compliant images of individual devices showed AUC scores of 98.2%, 92.8%, and 100%, respectively. These findings highlight deep learning's potential for quantitative and objective assessments of ultrasound image quality. Ultimately, this framework provides a streamlined approach to quality management, enabling consistent quality control and efficient scoring-based evaluation of ultrasound equipment.
rights: Copyright © 2024 Elsevier B.V. All rights reserved.
has PII: S1386-5056(24)00361-7
doi: 10.1016/j.ijmedinf.2024.105698
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Jang DH
      type: Person
      first name: Dong Hoon
      last name: Jang
      member of: Department of Electrical and Computer Engineering, Inha University, Incheon, Republic of Korea. Electronic address: ehdgnsdl9192@gmail.com.
  slot:
    index: 2
    item: Heo JW
      type: Person
      first name: Ji Won
      last name: Heo
      member of: Department of Computer Science, Inha University, Incheon, Republic of Korea.
  slot:
    index: 3
    item: Lee KH
      type: Person
      first name: Kyu Hong
      last name: Lee
      member of: Department of Radiology, Inha University College of Medicine, Incheon, Republic of Korea.
  slot:
    index: 4
    item: Lee RW
      type: Person
      first name: Ro Woon
      last name: Lee
      member of: Department of Radiology, Inha University College of Medicine, Incheon, Republic of Korea.
  slot:
    index: 5
    item: Ahn TR
      type: Person
      first name: Tae Ran
      last name: Ahn
      member of: Department of Radiology, Gil Medical Center, Gachon University School of Medicine, Incheon, Republic of Korea.
  slot:
    index: 6
    item: Lee HG
      type: Person
      first name: Hyun Gyu
      last name: Lee
      member of: Department of Electrical and Computer Engineering, Inha University, Incheon, Republic of Korea; College of Medicine, Inha University, Incheon, Republic of Korea. Electronic address: hglee@inha.ac.kr.
created: 2024-11-14T18:31
date last updated: 2025-03-08
issued: 2025-01
dp: 2025 Jan
created: 2024-11-14T18:00
e ISSN: 1872-8243
has issn l: 1386-5056
has NLM journal title abbreviation: Int J Med Inform
publication name: International journal of medical informatics
language: eng
has national library of medicine journal id: 9711057
derived from: NLM
pg: 105698
has place of publication: Ireland
has primary subject term: D014463Q000145Q000295Q000592
has primary subject term: D007091Q000145Q000379Q000592
has primary subject term: D019047Q000145Q000592Q000706
has primary subject term: D011786
has subject term: D066264
has subject term: D006801
has subject term: D019540
has subject term: D016015
source: Int J Med Inform. 2025-01;193():105698.
volume: 193

Dutcher bodies and Russell bodies in a case of t(11;14) multiple myeloma.
pmid: 39543449
doi: 10.1111/bjh.19890
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wu J
      type: Person
      first name: Jing
      last name: Wu
      member of: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  slot:
    index: 2
    item: Cai W
      type: Person
      first name: Wei
      last name: Cai
      member of: Department of Laboratory Medicine, University Town Hospital of Chongqing Medical University, Chongqing, China.
  slot:
    index: 3
    item: Jiang M
      type: Person
      first name: Mi
      last name: Jiang
      member of: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
created: 2024-11-15T06:24
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-15T00:03
e ISSN: 1365-2141
has issn l: 0007-1048
issue: 3
has NLM journal title abbreviation: Br J Haematol
publication name: British journal of haematology
language: eng
has national library of medicine journal id: 0372544
derived from: NLM
starting page: 810
ending page: 811
has place of publication: England
source: Br J Haematol. 2025-03;206(3):810-811.
volume: 206

Transradial versus transfemoral access for mechanical thrombectomy: A single institution experience.
pmid: 39544024
abstract: There has been debate in the literature regarding the adoption of a radial-first approach for mechanical thrombectomy (MT) in acute ischemic stroke (AIS). Conflicting reports suggest that transradial access (TRA) may allow for shorter times to reperfusion while others conclude that long-term functional outcomes may favor transfemoral access (TFA). Here, we report a single-institution experience with the adoption of TRA as the primary route for acute stroke intervention.We retrospectively reviewed a single-institution database of patients undergoing MT for AIS from March 2020 to April 2023. This time period was selected to capture the change in clinical practice at our institution from TFA to TRA. Primary and secondary outcomes included technical success, procedural complications, and long-term functional outcomes. Patients were stratified into two cohorts from initial access. Cohorts were compared utilizing inferential statistics.A total of 192 consecutive cases were identified, with 80 in the TFA cohort and 112 in the TRA cohort. There was no difference in outcomes with respect to time from puncture to recanalization, rates of successful recanalization (TICI ≥ 2b), number of passes, rates of symptomatic intracranial hemorrhage (sICH), modified Rankin scale (mRS) at discharge and 90 days, and 90-day mortality (p ≥ 0.05, all). The TRA had a higher rate of access conversion (p < 0.001), while the TFA cohort had a higher rate of access site complications (p < 0.05).
doi: 10.1177/15910199241298725
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Bram R
      type: Person
      first name: Richard
      last name: Bram
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  slot:
    index: 2
    item: Nie JW
      type: Person
      first name: James W
      last name: Nie
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  slot:
    index: 3
    item: Theiss P
      type: Person
      first name: Peter
      last name: Theiss
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  slot:
    index: 4
    item: Marotta D
      type: Person
      first name: Dario
      last name: Marotta
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  slot:
    index: 5
    item: Hillman M
      type: Person
      first name: Maureen
      last name: Hillman
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  slot:
    index: 6
    item: Alaraj A
      type: Person
      first name: Ali
      last name: Alaraj
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  slot:
    index: 7
    item: Atwal GS
      type: Person
      first name: Gursant S
      last name: Atwal
      member of: Department of Neurosurgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
created: 2024-11-15T06:24
date last updated: 2025-03-09
issued: 2024-11-15
dp: 2024 Nov 15
created: 2024-11-15T03:23
e ISSN: 2385-2011
has issn l: 1591-0199
has NLM journal title abbreviation: Interv Neuroradiol
publication name: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
language: eng
has national library of medicine journal id: 9602695
derived from: NLM
pg: 15910199241298725
has place of publication: United States
source: Interv Neuroradiol. 2024-11-15;():15910199241298725.

Historical Perspectives of the Korean Society for Thoracic and Cardiovascular Surgery: Sung Nok Hong (1927-2017) Who Performed the First Coronary Artery Bypass Graft in Korea.
pmid: 39552037
has PII: jcs.24.100
doi: 10.5090/jcs.24.100
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lee DY
      type: Person
      first name: Doo Yun
      last name: Lee
      member of: Department of Thoracic and Cardiovascular Surgery, G Sam Hospital, Gunpo, Korea.
  slot:
    index: 2
    item: Paik HC
      type: Person
      first name: Hyo Chae
      last name: Paik
      member of: Deparment of Thoracic and Cardiovascular Surgery, Myeong-Ji Hospital, Seoul, Korea.
  slot:
    index: 3
    item: Chang BC
      type: Person
      first name: Byung Chul
      last name: Chang
      member of: Deparment of Thoracic and Cardiovascular Surgery, Cha Bundang Medical Center, Seongnam, Korea.
  slot:
    index: 4
    item: Kang MS
      type: Person
      first name: Meyun-Shick
      last name: Kang
      member of: Deparment of Thoracic and Cardiovascular Surgery, Yonsei University Medical College, Seoul, Korea.
  slot:
    index: 5
    item: Park KY
      type: Person
      first name: Kook-Yang
      last name: Park
      member of: Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Incheon, Korea.
created: 2024-11-18T06:22
date last updated: 2025-03-09
issued: 2025-03-05
dp: 2025 Mar 05
created: 2024-11-18T00:53
ISSN: 2765-1606
has issn l: 2765-1606
issue: 2
has NLM journal title abbreviation: J Chest Surg
publication name: Journal of chest surgery
language: eng
has national library of medicine journal id: 101775790
derived from: NLM
starting page: 73
ending page: 76
has place of publication: Korea (South)
source: J Chest Surg. 2025-03-05;58(2):73-76.
volume: 58

Can we better understand strabismus research?
pmid: 39558092
has PII: 10.1038/s41433-024-03491-6
doi: 10.1038/s41433-024-03491-6
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Gou S
      type: Person
      first name: Suqing
      last name: Gou
      member of: The Second Affiliated Hospital & Yuying Children' Hospital of Wenzhou Medical University, Department of Ophthalmology, Wenzhou, 325000, China.
  slot:
    index: 2
    item: Chen J
      type: Person
      first name: Jiexiao
      last name: Chen
      member of: New York University, Steinhardt School of Culture, Education, and Human Development, New York, 10012, USA.
  slot:
    index: 3
    item: Chen J
      type: Person
      first name: Jieling
      last name: Chen
      member of: The Second Affiliated Hospital & Yuying Children' Hospital of Wenzhou Medical University, Department of Ophthalmology, Wenzhou, 325000, China. 894425084@qq.com.
created: 2024-11-19T00:22
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-18T23:49
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 798
ending page: 799
has place of publication: England
source: Eye (Lond). 2025-03;39(4):798-799.
volume: 39

Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache.
pmid: 39563240
abstract: Headache is a pain disorder present in populations world-wide with a higher incidence in females. Specifically, the incidences of medication overuse headache (MOH) have increased worldwide. Comorbidities of MOH include photosensitivity, anxiety, brain fog , and decreased physical activity. The FDA-approved long-lasting selective β2-adrenergic receptor agonist, formoterol, is currently approved for use in severe asthma and chronic obstructive pulmonary disease. Recently, interest in repurposing formoterol for use in other disorders including Alzheimer's disease, and neuropathic pain after spinal cord injury and traumatic brain injury has gained traction. Thus, revisiting known side-effects of formoterol, like headache and anxiety, could inform treatment paradigms. The endocannabinoid (eCB) system is implicated in the etiology of preclinical headache, with observed decreases in the circulating levels of endogenous cannabinoids, referred to as Clinical Endocannabinoid Deficiency. As cross-talk between the eCB system and adrenergic receptors has been reported, this study investigated the role of the eCB system and ability of formoterol to induce headache-like periorbital allodynic behavior.Female 8-week-old C57Bl/6J mice were treated daily with formoterol (0.3 mg/kg, i.p.) for up to 42-days, during which they were assessed for periorbital allodynia, open field/novel object recognition, and photosensitivity. At the end of the study, the periaqueductal grey (PAG), a brain region known to contribute to both headache induction and maintenance, was collected and subjected to LC-MS to quantify endocannabinoid levels.Mice exhibited periorbital allodynia at nearly all time points tested and photosensitivity from 28-days onward. Levels of endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), along with cannabinoid receptor 1 (CB1R) expression were altered by both age and upon treatment with formoterol. Administration of FAAH/MAGL inhibitors, to target the eCB sys[cell cut: 2428 characters, first 2000 kept]
rights: © 2024. The Author(s).
has PII: 10.1186/s10194-024-01907-y
doi: 10.1186/s10194-024-01907-y
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Peterson IL
      type: Person
      first name: Ingrid L
      last name: Peterson
      member of: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.
  slot:
    index: 2
    item: Liktor-Busa E
      type: Person
      first name: Erika
      last name: Liktor-Busa
      member of: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.
  slot:
    index: 3
    item: Karlage KL
      type: Person
      first name: Kelly L
      last name: Karlage
      member of: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.
  slot:
    index: 4
    item: Young SJ
      type: Person
      first name: Sally J
      last name: Young
      member of: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.
  slot:
    index: 5
    item: Scholpa NE
      type: Person
      first name: Natalie E
      last name: Scholpa
      member of: Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States.Southern Arizona VA Health Care System, Tucson, AZ, United States.
  slot:
    index: 6
    item: Schnellmann RG
      type: Person
      first name: Rick G
      last name: Schnellmann
      member of: Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States.Southern Arizona VA Health Care System, Tucson, AZ, United States.Southwest Environmental Health Science Center, University of Arizona, Tucson, AZ, United States.Department of Neuroscience, College of Medicine, University of Arizona, Tucson, AZ, United States.Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States.
  slot:
    index: 7
    item: Largent-Milnes TM
      type: Person
      first name: Tally M
      last name: Largent-Milnes
      member of: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States. tlargent@arizona.edu.
created: 2024-11-20T11:04
date last updated: 2025-03-09
issued: 2024-11-19
dp: 2024 Nov 19
created: 2024-11-20T03:04
e ISSN: 1129-2377
has issn l: 1129-2369
issue: 1
has NLM journal title abbreviation: J Headache Pain
publication name: The journal of headache and pain
language: eng
has national library of medicine journal id: 100940562
derived from: NLM
pg: 200
has place of publication: England
has primary subject term: D063388Q000378
has primary subject term: D010487Q000378Q000187
has primary subject term: D000068759Q000494
has subject term: D000818
has subject term: D005260
has subject term: D051379
has subject term: D008810
has subject term: D006930Q000139Q000378
has subject term: D058666Q000494
has subject term: D006261Q000139Q000378Q000188
has subject term: D004195
source: J Headache Pain. 2024-11-19;25(1):200.
volume: 25

Dopamine D1 and NMDA Receptor Co-Regulation of Protein Translation in Cultured Nucleus Accumbens Neurons.
pmid: 39567459
abstract: Protein translation is essential for some forms of synaptic plasticity. Here we used fluorescent noncanonical amino acid tagging (FUNCAT) to examine whether dopamine modulates protein translation in cultured nucleus accumbens (NAc) medium spiny neurons (MSN). These neurons were co-cultured with cortical neurons to restore excitatory synapses. We measured translation in MSNs under basal conditions and after disinhibiting excitatory transmission using the GABAA receptor antagonist bicuculline (2 h). Under basal conditions, translation was not altered by the D1-class receptor (D1R) agonist SKF81297 or the D2-class receptor (D2R) agonist quinpirole. Bicuculline alone robustly increased translation. This was reversed by quinpirole but not SKF81297. It was also reversed by co-incubation with the D1R antagonist SCH23390, but not the D2R antagonist eticlopride, suggesting dopaminergic tone at D1Rs. This was surprising because no dopamine neurons are present. An alternative explanation is that bicuculline activates translation by increasing glutamate tone at NMDA receptors (NMDAR) within D1R/NMDAR heteromers. Supporting this, immunocytochemistry and proximity ligation assays revealed D1R/NMDAR heteromers on NAc cells both in vitro and in vivo, confirming previous results. Furthermore, bicuculline's effect was reversed to the same extent by SCH23390 alone, the NMDAR antagonist APV alone, or SCH23390 + APV. These results suggest that: (1) excitatory transmission stimulates translation in NAc MSNs, (2) this is opposed when glutamate activates D1R/NMDAR heteromers, even in the absence of dopamine, and (3) antagonist occupation of D1Rs within the heteromers prevents their activation. Our study is the first to suggest a role for D2 receptors and D1R/NMDAR heteromers in regulating protein translation.
rights: © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s11064-024-04283-w
doi: 10.1007/s11064-024-04283-w
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Zimbelman AR
      type: Person
      first name: Alexa R
      last name: Zimbelman
      member of: Department of Psychology and Neuroscience, North Central College, 30 N. Brainard St., Naperville, IL, 60540, USA.
  slot:
    index: 2
    item: Wong B
      type: Person
      first name: Benjamin
      last name: Wong
      member of: Department of Psychology and Neuroscience, North Central College, 30 N. Brainard St., Naperville, IL, 60540, USA.
  slot:
    index: 3
    item: Murray CH
      type: Person
      first name: Conor H
      last name: Murray
      member of: Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.Present Address: UCLA Center for Cannabis and Cannabinoids, Semel Institute for Neuroscience & Human Behavior, Los Angeles, CA, 90025, USA.
  slot:
    index: 4
    item: Wolf ME
      type: Person
      first name: Marina E
      last name: Wolf
      member of: Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.Present Address: Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97212, USA.
  slot:
    index: 5
    item: Stefanik MT
      type: Person
      first name: Michael T
      last name: Stefanik
      member of: Department of Psychology and Neuroscience, North Central College, 30 N. Brainard St., Naperville, IL, 60540, USA. mtstefanik@noctrl.edu.Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA. mtstefanik@noctrl.edu.
created: 2024-11-21T00:22
date last updated: 2025-03-09
issued: 2024-11-21
dp: 2024 Nov 21
created: 2024-11-20T23:16
e ISSN: 1573-6903
has issn l: 0364-3190
issue: 1
has NLM journal title abbreviation: Neurochem Res
publication name: Neurochemical research
language: eng
has national library of medicine journal id: 7613461
derived from: NLM
pg: 27
has place of publication: United States
has primary subject term: D017447Q000378
has primary subject term: D009714Q000378Q000187
has primary subject term: D016194Q000378
has primary subject term: D014176Q000187
has primary subject term: D009474Q000378Q000187
has subject term: D000818
has subject term: D002478
has subject term: D051381
has subject term: D017207
has subject term: D001640Q000494
source: Neurochem Res. 2024-11-21;50(1):27.
volume: 50

EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE.
pmid: 39574609
abstract: Exosomes are extracellular vesicles secreted by cells that contain microRNAs (miRNAs). These miRNAs can induce changes in gene expression and function of recipient cells. In different cells exosome content can change with age and physiological state affecting tissues function and health.Therefore, the aim of this study was to characterize the miRNA content and role of exosomes from cyclic female mice in the modulation of liver transcriptome in estropausal mice.Two-month-old female mice were induced to estropause using 4-vinylcyclohexene diepoxide (VCD). At six months of age VCD-treated mice were divided in control group (VCD) and exosome treated group (VCD+EXO), which received 10 injections at 3-day intervals of exosomes extracted from serum of cyclic female mice (CTL).Exosome injection in estropausal mice had no effect on body mass, insulin sensitivity or organ weight. We observed ten miRNAs differentially regulated in serum exosomes of VCD compared to CTL mice. In the liver we observed 931 genes differentially expressed in VCD+EXO compared to VCD mice. Interestingly, eight pathways were up-regulated in liver by VCD treatment and down-regulated by exosome treatment, indicating that exosomes from cyclic mice can reverse changes promoted by estropause in liver. Cyp4a12a expression which is male-specific was increased in VCD females and not reversed by exosome treatment.Our findings indicate that miRNAs content in exosomes is regulated by estropause in mice independent of age. Additionally, treatment of estropausal mice with exosomes from cyclic mice can partially reverse changes in liver transcriptome.
doi: 10.1101/2024.11.04.621842
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Zanini BM
      type: Person
      first name: Bianka M
      last name: Zanini
      member of: Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas - RS, Brazil.
  slot:
    index: 2
    item: Ávila BM
      type: Person
      first name: Bianca M
      last name: Ávila
      member of: Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas - RS, Brazil.
  slot:
    index: 3
    item: Hense JD
      type: Person
      first name: Jéssica D
      last name: Hense
      member of: Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas - RS, Brazil.
  slot:
    index: 4
    item: Garcia DN
      type: Person
      first name: Driele N
      last name: Garcia
      member of: Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas - RS, Brazil.
  slot:
    index: 5
    item: Ashiqueali S
      type: Person
      first name: Sarah
      last name: Ashiqueali
      member of: College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
  slot:
    index: 6
    item: Alves PIC
      type: Person
      first name: Pâmela I C
      last name: Alves
      member of: Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos, Universidade Federal de Pelotas -RS, Brasil.
  slot:
    index: 7
    item: Oliveira TL
      type: Person
      first name: Thais L
      last name: Oliveira
      member of: Centro de Biotecnologia, Universidade Federal de Pelotas - RS, Brasil.
  slot:
    index: 8
    item: Collares TV
      type: Person
      first name: Tiago V
      last name: Collares
      member of: Centro de Biotecnologia, Universidade Federal de Pelotas - RS, Brasil.
  slot:
    index: 9
    item: Brieño-Enríquez MA
      type: Person
      first name: Miguel A
      last name: Brieño-Enríquez
      member of: Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  slot:
    index: 10
    item: Mason JB
      type: Person
      first name: Jeffrey B
      last name: Mason
      member of: College of Veterinary Medicine, Department of Veterinary Clinical and Life Sciences, Center for Integrated BioSystems, Utah State University, Logan, UT, USA.
  slot:
    index: 11
    item: Masternak MM
      type: Person
      first name: Michal M
      last name: Masternak
      member of: University of Central Florida, College of Medicine, Burnett School of Biomedical Sciences, Orlando, Florida, USA.Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland.
  slot:
    index: 12
    item: Schneider A
      type: Person
      first name: Augusto
      last name: Schneider
      member of: Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas - RS, Brazil.
created: 2024-11-22T11:25
date last updated: 2025-03-08
issued: 2024-11-06
dp: 2024 Nov 06
created: 2024-11-22T04:18
e ISSN: 2692-8205
has issn l: 2692-8205
has NLM journal title abbreviation: bioRxiv
publication name: bioRxiv : the preprint server for biology
language: eng
has national library of medicine journal id: 101680187
derived from: NLM
has place of publication: United States
source: bioRxiv. 2024-11-06;():.

Correction to: Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma.
pmid: 39576720
has PII: 7907202
doi: 10.1093/brain/awae353
created: 2024-11-22T18:17
date last updated: 2025-03-09
issued: 2025-03-06
dp: 2025 Mar 06
created: 2024-11-22T12:23
e ISSN: 1460-2156
has issn l: 0006-8950
issue: 3
has NLM journal title abbreviation: Brain
publication name: Brain : a journal of neurology
language: eng
has national library of medicine journal id: 0372537
derived from: NLM
starting page: e16
ending page: e20
has place of publication: England
source: Brain. 2025-03-06;148(3):e16-e20.
volume: 148

Usefulness of the right lateral decubitus push method in endoscopic submucosal dissection for upper gastric lesions.
pmid: 39582398
doi: 10.1111/den.14945
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Matsunaga T
      type: Person
      first name: Takuya
      last name: Matsunaga
      member of: Department of Gastroenterology, Saga Medical Centre Koseikan, Saga, Japan.
  slot:
    index: 2
    item: Tominaga N
      type: Person
      first name: Naoyuki
      last name: Tominaga
      member of: Department of Gastroenterology, Saga Medical Centre Koseikan, Saga, Japan.
  slot:
    index: 3
    item: Ogata S
      type: Person
      first name: Shinichi
      last name: Ogata
      member of: Department of Gastroenterology, Saga Medical Centre Koseikan, Saga, Japan.
created: 2024-11-25T11:33
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-25T04:23
e ISSN: 1443-1661
has issn l: 0915-5635
issue: 3
has NLM journal title abbreviation: Dig Endosc
publication name: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
language: eng
has national library of medicine journal id: 9101419
derived from: NLM
starting page: 300
ending page: 301
has place of publication: Australia
source: Dig Endosc. 2025-03;37(3):300-301.
volume: 37

Macrophage tracking with USPIO imaging and T2 mapping predicts immune rejection of transplanted stem cells.
pmid: 39587241
abstract: To develop a clinical imaging method for monitoring macrophage migration to the defect site after implantation of various stem cells and evaluating immune responses in the context of knee arthritis, T2 mapping was correlated with CD68-positive cell densities in defects and the bone marrow. This study, which was approved by the Institutional Animal Care and Use Committee, used 32 New Zealand white rabbits preloaded with ultrasmall superparamagnetic iron oxide particles (USPIOs). They were divided into groups that received different stem cell implants after osteochondral defect induction. T2 imaging was performed using a 3.0 T MR scanner, and the data were analysed via one-way ANOVA, with CD68 expression assessed via immunohistochemistry. After implantation, the T2 signal intensity increased across groups, with subgroup D1 (implantation of rat bone marrow stem cells (BMSCs)) showing the lowest T2 value early and the steepest increase in T2 values. Notable differences in CD68-positive cell density were found between Subgroup D1 and the other groups and between Subgroups A1 and C1 post-surgery. A moderate negative correlation was observed between T2 signals and CD68-positive cell density in defects (r = -0.468, p = 0.001), whereas a weak correlation was detected in the bone marrow (r = 0.096, p = 0.313). A significant link was identified between CD68-positive cell density in the bone marrow and in defects (r = -0.255, p = 0.001). This study revealed significant differences in immune responses to stem cells from different origin tissues in the context of cartilage repair. Adipose-derived stem cells (ADSCs) were found to be more likely to provoke immune rejection than were BMSCs in the repair of femoral condyle cartilage defects. Compared with allogeneic transplants, xenogeneic mesenchymal stem cell transplants were associated with prolonged immune rejection. T2 mapping technology was effective in predicting the density of CD68-positive cells, providing a valuable tool fo[cell cut: 2041 characters, first 2000 kept]
rights: © 2024. The Author(s).
has PII: 10.1038/s41598-024-80750-2
doi: 10.1038/s41598-024-80750-2
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Wang W
      type: Person
      first name: Wenhui
      last name: Wang
      member of: Department of Radiology, The First Affiliated Hospital, Dalian Medical University, Dalian, 116000, Liaoning, China.College of Medical Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
  slot:
    index: 2
    item: Liu Z
      type: Person
      first name: Zhenyu
      last name: Liu
      member of: College of Medical Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
  slot:
    index: 3
    item: Zhu J
      type: Person
      first name: Jiahong
      last name: Zhu
      member of: Department of Radiology, Taiyuan Hospital of Traditional Chinese Medicine, Taiyuan, 030001, Shanxi, China.
  slot:
    index: 4
    item: Zhen H
      type: Person
      first name: Haocheng
      last name: Zhen
      member of: Clinical and Basic Medical College, Shandong First Medical University, Jinan, 250000, Shandong, China.
  slot:
    index: 5
    item: Qi M
      type: Person
      first name: Meiling
      last name: Qi
      member of: College of Medical Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
  slot:
    index: 6
    item: Luo J
      type: Person
      first name: Jing
      last name: Luo
      member of: Department of Rheumatology and immunology, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
  slot:
    index: 7
    item: Zhen J
      type: Person
      first name: Junping
      last name: Zhen
      member of: Department of Rheumatology and immunology, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China. Zhenjunping2016@163.com.Department of Magnetic Resonance, Faculty of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China. Zhenjunping2016@163.com.
created: 2024-11-26T00:17
date last updated: 2025-03-09
issued: 2024-11-25
dp: 2024 11 25
created: 2024-11-25T23:52
e ISSN: 2045-2322
has issn l: 2045-2322
issue: 1
has NLM journal title abbreviation: Sci Rep
publication name: Scientific reports
language: eng
has national library of medicine journal id: 101563288
derived from: NLM
pg: 29162
has place of publication: England
has primary subject term: D008264Q000276
has primary subject term: D008279Q000379
has subject term: D000818
has subject term: D011817
has subject term: D051381
has subject term: D058948Q000379
has subject term: D033581Q000379
has subject term: D006084Q000276
has subject term: D058185
has subject term: D015214Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000082662
has subject term: D008297
has subject term: D015703Q000378
has subject term: D045164Q000379
source: Sci Rep. 2024-11-25;14(1):29162.
volume: 14

Cataract surgery: a public health crisis with your name on it.
pmid: 39592815
has PII: 10.1038/s41433-024-03502-6
doi: 10.1038/s41433-024-03502-6
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ellis JD
      type: Person
      first name: John D
      last name: Ellis
      member of: Department of Ophthalmology, Ninewells Hospital, NHS Tayside, James Arrott Dr, Dundee, DD2 1SG, UK. john.ellis4@nhs.scot.
  slot:
    index: 2
    item: Kousha O
      type: Person
      first name: Obaid
      last name: Kousha
      member of: Department of Ophthalmology, Ninewells Hospital, NHS Tayside, James Arrott Dr, Dundee, DD2 1SG, UK.Infection & Global Health Division, School of Medicine Medical and Biological Sciences Building, North Haugh, St Andrews, KY16 9TF, UK.
  slot:
    index: 3
    item: Sivanesan O
      type: Person
      first name: Omkaar
      last name: Sivanesan
      member of: Department of Ophthalmology, Ninewells Hospital, NHS Tayside, James Arrott Dr, Dundee, DD2 1SG, UK.
  slot:
    index: 4
    item: Murray W
      type: Person
      first name: Whitney
      last name: Murray
      member of: Department of Ophthalmology, Ninewells Hospital, NHS Tayside, James Arrott Dr, Dundee, DD2 1SG, UK.
created: 2024-11-27T00:21
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-26T23:46
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 613
ending page: 615
has place of publication: England
source: Eye (Lond). 2025-03;39(4):613-615.
volume: 39

Resistance gene enrichment sequencing refines the Brassica napus NLRome.
pmid: 39603796
has PII: 7911763
doi: 10.1093/plphys/kiae631
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wu 吴家旭 J
      type: Person
      first name: Jiaxu
      last name: Wu 吴家旭
      member of: Départment de Phytologie, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec City, QC, Canada G1V 0A6.Centre de Recherche et d'innovation sur les Végétaux (CRIV), Université Laval, Québec City, QC, Canada G1V 0A6.Institute de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec City, QC, Canada G1V 0A6.L'Institute EDS, Université Laval, Québec City, QC, Canada G1V 0A6.
  slot:
    index: 2
    item: Mukhopadhyay S
      type: Person
      first name: Soham
      last name: Mukhopadhyay
      member of: Départment de Phytologie, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec City, QC, Canada G1V 0A6.Centre de Recherche et d'innovation sur les Végétaux (CRIV), Université Laval, Québec City, QC, Canada G1V 0A6.Institute de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec City, QC, Canada G1V 0A6.L'Institute EDS, Université Laval, Québec City, QC, Canada G1V 0A6.
  slot:
    index: 3
    item: Pérez-López E
      type: Person
      first name: Edel
      last name: Pérez-López
      member of: Départment de Phytologie, Faculté des Sciences de l'agriculture et de l'alimentation, Université Laval, Québec City, QC, Canada G1V 0A6.Centre de Recherche et d'innovation sur les Végétaux (CRIV), Université Laval, Québec City, QC, Canada G1V 0A6.Institute de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec City, QC, Canada G1V 0A6.L'Institute EDS, Université Laval, Québec City, QC, Canada G1V 0A6.
created: 2024-11-28T00:24
date last updated: 2025-03-09
issued: 2025-03-01
dp: 2025 Mar 01
created: 2024-11-27T21:13
e ISSN: 1532-2548
has issn l: 0032-0889
issue: 3
has NLM journal title abbreviation: Plant Physiol
publication name: Plant physiology
language: eng
has national library of medicine journal id: 0401224
derived from: NLM
has place of publication: United States
source: Plant Physiol. 2025-03-01;197(3):.
volume: 197

The safety and efficacy of pRESET stent retriever for treatment of thrombo-embolic stroke; a systematic review and meta-analysis.
pmid: 39604086
abstract: The pRESET stent retriever is a self-expanding nitinol stent designed for mechanical thrombectomy in cases of large vessel occlusion during acute ischemic stroke. This systematic review and meta-analysis synthesize the available evidence on the safety and efficacy of the pRESET device.This is a systematic review and meta-analysis study conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The electronic databases of PubMed, Embase, WoS, and Scopus were systematically reviewed from inception to 8 July 2024.A total of eight studies involving 1163 patients were included. The pooled mortality rate was 18% with a 95% CI of [12%, 25%]. The rates of any hemorrhagic complication, parenchymal hemorrhage, and subarachnoid hemorrhage were 22% with a 95% CI of [12%, 36%], 7% with a 95% CI of [4%, 13%], and 10% with a 95% CI of [5%, 17%], respectively. The rate of favorable functional outcome (modified Rankin Scale 0-2) at 90 days was 43% with a 95% CI of [34%, 52%]. Successful recanalization rates were 60% with a 95% CI of [52%, 67%] after the first pass and 90% with a 95% CI of [83%, 95%] after the final pass. Rescue devices were used in 13% with a 95% CI of [7%, 24%] of cases.The pRESET stent retriever demonstrates high recanalization rates and reasonable safety outcomes in patients undergoing mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion. Further randomized trials directly comparing pRESET to other stent retrievers are warranted.
doi: 10.1177/19714009241303083
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Habibi MA
      type: Person
      first name: Mohammad Amin
      last name: Habibi
      member of: Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Ahmadvand MH
      type: Person
      first name: Muhammad Hussain
      last name: Ahmadvand
      member of: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Delbari P
      type: Person
      first name: Pouria
      last name: Delbari
      member of: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 4
    item: Sabet S
      type: Person
      first name: Saba
      last name: Sabet
      member of: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 5
    item: Zare AH
      type: Person
      first name: Amir Hessam
      last name: Zare
      member of: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 6
    item: Mirjani MS
      type: Person
      first name: Mohammad Sina
      last name: Mirjani
      member of: Student Research Committee, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
  slot:
    index: 7
    item: Boskabadi AR
      type: Person
      first name: Amir Reza
      last name: Boskabadi
      member of: Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
  slot:
    index: 8
    item: Kolur ZA
      type: Person
      first name: Zahra Aslani
      last name: Kolur
      member of: Student Research Committee, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
  slot:
    index: 9
    item: Bozorgi M
      type: Person
      first name: Maryam
      last name: Bozorgi
      member of: Student Research Committee, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
created: 2024-11-28T00:24
date last updated: 2025-03-09
issued: 2024-11-27
dp: 2024 Nov 27
created: 2024-11-27T23:53
e ISSN: 2385-1996
has issn l: 1971-4009
has NLM journal title abbreviation: Neuroradiol J
publication name: The neuroradiology journal
language: eng
has national library of medicine journal id: 101295103
derived from: NLM
pg: 19714009241303083
has place of publication: United States
source: Neuroradiol J. 2024-11-27;():19714009241303083.

Buprenorphine Induces Human Fetal Membrane Sterile Inflammation.
pmid: 39605446
abstract: Opioid-use disorder (OUD) during pregnancy has increased in the United States to critical levels and is a leading cause of maternal morbidity and mortality. Untreated OUD is associated with pregnancy complications in particular, preterm birth. Medications for OUD, such as buprenorphine, are recommended with the added benefit that treatment during pregnancy increases treatment post-partum. However, the rate of preterm birth in individuals using illicit opioids or being treated with opioid agonist therapeutics is double that of the general population. Since inflammation in the placenta and the associated fetal membranes (FM) is a common underlying cause of preterm birth, we sought to determine if the opioid, buprenorphine, induces sterile inflammation in human FMs and to examine the mechanisms involved. Using an established in vitro human FM explant system, we report that buprenorphine significantly increased FM secretion of the inflammatory cytokine IL-6; the neutrophilic chemokine IL-8; and the inflammasome-mediated cytokine IL-1β, mirroring the inflammatory profile commonly seen at the maternal-fetal interface in preterm birth. Other factors that were elevated in FMs exposed to buprenorphine included the mediators of membrane weakening, prostaglandin E2 (PGE2), and matrix metalloproteinases, MMP1 and MMP9. Furthermore, this sterile inflammatory and weakening FM response induced by buprenorphine was mediated in part by innate immune Toll-like receptor 4 (TLR4), the NLRP3 inflammasome, the μ-opioid receptor, and downstream NFκB and ERK/JNK/MAPK signaling. This may provide the mechanistic link between opioid use in pregnancy and the elevated risk for preterm birth. Since there are adverse consequences of not treating OUD, our findings may help identify ways to mitigate the impact opioids have on pregnancy outcomes while allowing the continuation of maintenance therapy.
doi: 10.1101/2024.11.22.624850
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lynn T
      type: Person
      first name: Tatyana
      last name: Lynn
  slot:
    index: 2
    item: Kelleher ME
      type: Person
      first name: Megan E
      last name: Kelleher
  slot:
    index: 3
    item: Georges HM
      type: Person
      first name: Hanah M
      last name: Georges
  slot:
    index: 4
    item: McCauley EM
      type: Person
      first name: Elle M
      last name: McCauley
  slot:
    index: 5
    item: Logan RW
      type: Person
      first name: Ryan W
      last name: Logan
  slot:
    index: 6
    item: Yonkers KA
      type: Person
      first name: Kimberly A
      last name: Yonkers
  slot:
    index: 7
    item: Abrahams VM
      type: Person
      first name: Vikki M
      last name: Abrahams
created: 2024-11-28T06:35
date last updated: 2025-03-08
issued: 2024-11-22
dp: 2024 Nov 22
created: 2024-11-28T04:47
e ISSN: 2692-8205
has issn l: 2692-8205
has NLM journal title abbreviation: bioRxiv
publication name: bioRxiv : the preprint server for biology
language: eng
has national library of medicine journal id: 101680187
derived from: NLM
has place of publication: United States
source: bioRxiv. 2024-11-22;():.

Transcriptomic analysis of nicotine on the cardiovascular system using a diverse population of human induced pluripotent stem cell-derived endothelial cells.
pmid: 39608091
has PII: S0022-2828(24)00190-1
doi: 10.1016/j.yjmcc.2024.11.001
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Jimenez-Tellez N
      type: Person
      first name: Nerea
      last name: Jimenez-Tellez
      member of: Stanford Cardiovascular Institute, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  slot:
    index: 2
    item: Williams D
      type: Person
      first name: Damon
      last name: Williams
      member of: Stanford Cardiovascular Institute, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  slot:
    index: 3
    item: Liu Y
      type: Person
      first name: Yu
      last name: Liu
      member of: Stanford Cardiovascular Institute, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  slot:
    index: 4
    item: Wang M
      type: Person
      first name: Mingqiang
      last name: Wang
      member of: Stanford Cardiovascular Institute, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  slot:
    index: 5
    item: Chandy M
      type: Person
      first name: Mark
      last name: Chandy
      member of: Stanford Cardiovascular Institute, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Medicine, Western University, London, ON, Canada. Electronic address: mchandy2@uwo.ca.
  slot:
    index: 6
    item: Wu JC
      type: Person
      first name: Joseph C
      last name: Wu
      member of: Stanford Cardiovascular Institute, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: joewu@stanford.edu.
created: 2024-11-29T05:21
date last updated: 2025-03-09
issued: 2025-01
dp: 2025 Jan
created: 2024-11-28T18:03
e ISSN: 1095-8584
has issn l: 0022-2828
has NLM journal title abbreviation: J Mol Cell Cardiol
publication name: Journal of molecular and cellular cardiology
language: eng
has national library of medicine journal id: 0262322
derived from: NLM
starting page: 21
ending page: 23
has place of publication: England
source: J Mol Cell Cardiol. 2025-01;198():21-23.
volume: 198

Hidden link between endocrine-disrupting chemicals and pediatric obesity.
pmid: 39608365
abstract: The increasing prevalence of pediatric obesity has emerged as a significant public health concern. Among various contributing factors, exposure to endocrine-disrupting chemicals (EDCs) has gained recognition for its potential role. EDCs, including bisphenols, phthalates, per- and polyfluoroalkyl substances, polycyclic aromatic hydrocarbons, and organochlorines, disrupt hormonal regulation and metabolic processes, contributing to alterations in fat storage, appetite regulation, and insulin sensitivity. This study offers a comprehensive review of the current research linking EDC exposure to pediatric obesity by integrating the findings from experimental and epidemiological studies. It also addresses the complexities of interpreting this evidence in the context of public health, highlighting the urgent need for further research.
has PII: cep.2024.00556
doi: 10.3345/cep.2024.00556
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Shin MW
      type: Person
      first name: Min Won
      last name: Shin
      member of: Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
  slot:
    index: 2
    item: Kim SH
      type: Person
      first name: Shin-Hye
      last name: Kim
      member of: Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
created: 2024-11-29T05:21
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-28T18:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 199
ending page: 222
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):199-222.
volume: 68

Long-term follow-up of neurocognitive function in patients with citrin deficiency and cholestasis.
pmid: 39608367
abstract: Citrin deficiency is a rare metabolic disorder prevalent in East and Southeast Asia that affects liver or neurological function throughout various life stages. While early diagnosis and dietary management can improve prognosis for infant onset disease, data on long-term neurocognitive outcomes is scarce.This study aimed to clarify whether transient metabolic disturbances during early childhood have a lasting effect on the neurocognitive function of individuals with citrin deficiency.Thirty patients diagnosed with citrin deficiency prior to 1 year of age underwent neuropsychological assessments including attention deficit/hyperactivity disorders (ADHD) and intelligence quotient (IQ). We compared the peak laboratory values during infancy between children who were versus were not later diagnosed with ADHD.Neurocognitive assessments of 30 individuals with citrin deficiency aged 3-25 years revealed that full-scale IQ scores were normally distributed. Of this cohort, 47% (14 of 30) were diagnosed with ADHD: 6, 6, and 2 with the combined, inattentive, and hyperactive-impulsive types, respectively. This prevalence was higher than that in the general population (1.7%-16%). Moreover, a one-unit increase in ammonia levels before 1 year of age was associated with a 1.023-fold increase in the likelihood of future hyperactivity-impulsivity symptoms (P=0.038; 95%confidence interval, 1.001-1.046). Despite these findings, this long-term follow-up of individuals with citrin deficiency indicated that it had minimal impact on neurocognitive function, allowing for a generally normal life.Patients with a history of cholestasis caused by citrin deficiency during infancy have a greater incidence of ADHD than the general population, suggesting that metabolic disturbances during early childhood in individuals with citrin deficiency may have a long-term negative impact on their neurocognitive function.
has PII: cep.2024.01102
doi: 10.3345/cep.2024.01102
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Tsai MM
      type: Person
      first name: Meng-Ju Melody
      last name: Tsai
      member of: Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.Department of Pediatrics, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
  slot:
    index: 2
    item: Chang JC
      type: Person
      first name: Jung-Chi
      last name: Chang
      member of: Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
  slot:
    index: 3
    item: Lu HY
      type: Person
      first name: Heng-Yu
      last name: Lu
      member of: Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
  slot:
    index: 4
    item: Gau SS
      type: Person
      first name: Susan Shur-Fen
      last name: Gau
      member of: Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
  slot:
    index: 5
    item: Chien YH
      type: Person
      first name: Yin-Hsiu
      last name: Chien
      member of: Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
  slot:
    index: 6
    item: Hwu WL
      type: Person
      first name: Wuh-Liang
      last name: Hwu
      member of: Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.Center for Precision Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  slot:
    index: 7
    item: Ni YH
      type: Person
      first name: Yen-Hsuan
      last name: Ni
      member of: Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.
  slot:
    index: 8
    item: Chen HL
      type: Person
      first name: Huey-Ling
      last name: Chen
      member of: Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.Department of Medical Education and Bioethics, National Taiwan University College of Medicine, Taipei, Taiwan.
  slot:
    index: 9
    item: Lee NC
      type: Person
      first name: Ni-Chung
      last name: Lee
      member of: Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
created: 2024-11-29T05:20
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-28T18:39
e ISSN: 2713-4148
has issn l: 2713-4148
issue: 3
has NLM journal title abbreviation: Clin Exp Pediatr
publication name: Clinical and experimental pediatrics
language: eng
has national library of medicine journal id: 101761234
derived from: NLM
starting page: 257
ending page: 265
has place of publication: Korea (South)
source: Clin Exp Pediatr. 2025-03;68(3):257-265.
volume: 68

Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis.
pmid: 39613260
abstract: The progress of cardiac hypertrophy is modulated by JAK2/STAT3 signaling pathway. Cardiac glucose metabolism derangement exacerbates the progression of cardiac hypertrophy. Oxytocin (OT) has emerged as a significant hormone involved in cardiovascular homeostasis, especially in protecting against cardiac hypertrophy. The present study aims to explore whether the anti-hypertrophy effect of oxytocin is related to the JAK2/STAT3 signaling pathway and cardiac glucose metablism.Cardiac hypertrophy model was induced by angiotensin II (Ang II) in H9c2 cells and in mice with or without oxytocin treatment. Changes in cardiac histopathology were evaluated by hematoxylin and eosin (H&E), Masson staining, and wheat germ agglutinin (WGA) staining. The hypertrophy-related genes and JAK2/STAT3 pathway signaling molecules were analyzed by qRT-PCR and western blotting. The levels of glucose, pyruvic acid, lactic acid, and lactate dehydrogenase activity in H9c2 cells using the corresponding assay kits.The results showed that OT inhibited hypertrophic and fibrotic changes. Furthermore, OT increased intracellular levels of glucose and pyruvic acid, and decreased lactate dehydrogenase activity and lactic acid levels. Mechanistically, Ang II decreased oxytocin receptors (OXTR) expression and facilitated JAK2 and STAT3 phosphorylation. OT treatment increased OXTR expression and blocked JAK2 and STAT3 phosphorylation The OXTR-specific siRNA-mediated depleted expression could abrogate OT-induced anti-hypertrophic effects in H9c2 cells following angiotensin II insult. However, the JAK2/STAT3 inhibitor AG490 rescued the protective effects of OT against cardiac hypertrophy under OXTR downregulation.OT exerts its protective effects against cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0196-9781(24)00176-1
doi: 10.1016/j.peptides.2024.171323
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Yang Y
      type: Person
      first name: Yuqiao
      last name: Yang
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 2
    item: Liu J
      type: Person
      first name: Jin
      last name: Liu
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 3
    item: Wang L
      type: Person
      first name: Lingyan
      last name: Wang
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 4
    item: Wu W
      type: Person
      first name: Wen
      last name: Wu
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 5
    item: Wang Q
      type: Person
      first name: Quan
      last name: Wang
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 6
    item: Zhao Y
      type: Person
      first name: Yu
      last name: Zhao
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 7
    item: Qian X
      type: Person
      first name: Xi
      last name: Qian
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 8
    item: Wang Z
      type: Person
      first name: Zhuoran
      last name: Wang
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 9
    item: Fu N
      type: Person
      first name: Na
      last name: Fu
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  slot:
    index: 10
    item: Wang Y
      type: Person
      first name: Yanqiong
      last name: Wang
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address: 664581041@qq.com.
  slot:
    index: 11
    item: Qian J
      type: Person
      first name: Jinqiao
      last name: Qian
      member of: Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address: qianjinqiao@126.com.
created: 2024-11-30T11:16
date last updated: 2025-03-08
issued: 2024-12
dp: 2024 Dec
created: 2024-11-29T19:37
e ISSN: 1873-5169
has issn l: 0196-9781
has NLM journal title abbreviation: Peptides
publication name: Peptides
language: eng
has national library of medicine journal id: 8008690
derived from: NLM
pg: 171323
has place of publication: United States
has primary subject term: D053614Q000378
has primary subject term: D010121Q000494Q000378
has primary subject term: D050796Q000378
has primary subject term: D006332Q000378Q000188Q000473Q000517
has primary subject term: D005947Q000378
has primary subject term: D018045Q000378Q000235
has primary subject term: D015398Q000187
has subject term: D000818
has subject term: D051379
has subject term: D008297
has subject term: D000804Q000494Q000378
has subject term: D051381
has subject term: D002460
has subject term: D009206Q000378Q000473
has subject term: D032383Q000378Q000187Q000473
source: Peptides. 2024-12;182():171323.
volume: 182

Advancing keratoconus treatment: the impact of bioengineered porcine constructs on corneal reshaping and visual acuity.
pmid: 39616278
has PII: 10.1038/s41433-024-03496-1
doi: 10.1038/s41433-024-03496-1
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Khan M
      type: Person
      first name: Maliha
      last name: Khan
      member of: Dow Medical College, Karachi, Pakistan. malihaadilkhan62@gmail.com.
  slot:
    index: 2
    item: Fatima D
      type: Person
      first name: Duaa
      last name: Fatima
      member of: Dow Medical College, Karachi, Pakistan.
created: 2024-12-1T15:22
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-30T23:27
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
pg: 616
has place of publication: England
source: Eye (Lond). 2025-03;39(4):616.
volume: 39

Intraocular endothelial Keratogel Device for protection corneal endothelium during phacoemulsification cataract surgery.
pmid: 39616280
has PII: 10.1038/s41433-024-03518-y
doi: 10.1038/s41433-024-03518-y
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Deshmukh R
      type: Person
      first name: Rashmi
      last name: Deshmukh
      member of: L.V. Prasad Eye Institute, Hyderabad, India. dr.rashmi9@gmail.com.
  slot:
    index: 2
    item: Vajpayee RB
      type: Person
      first name: Rasik B
      last name: Vajpayee
      member of: Royal Victorian Eye and Ear Hospital, Melbourne, Australia.Vision Eye Institute, Melbourne, Australia.University of Melbourne, Melbourne, Australia.
created: 2024-12-1T15:22
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-11-30T23:27
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 622
ending page: 623
has place of publication: England
source: Eye (Lond). 2025-03;39(4):622-623.
volume: 39

Three-Dimensional Analysis of Polyaxial Volar Locking Plate Position for Distal Radius Fracture.
pmid: 39619451
abstract: Background To avoid screw penetration into the joint when using the polyaxial volar locking plate (VLP) for osteosynthesis of distal radius fractures, it is important to note that the optimal screw insertion angles depending on the plate positions. Purpose The purpose of this study was 2-fold: first, to evaluate the differences of the most distal plate position where the screw does not penetrate into the joint in the three-dimensional (3D) radius models; second, to evaluate the relationship between the plate position and the transverse diameter of the distal radius. Patients and Methods Thirty plain X-rays and computed tomography (CT) scans of healthy wrists were evaluated. The transverse diameter was measured on plain X-rays. 3D radius models were reconstructed from CT data. A 3D image of polyaxial VLP was used to investigate the most distal plate position at three different screw insertion angles. The linear distance between the volar articular edge and the plate edge was measured and compared among different screw insertion angles. The correlations between the plate positions and the transverse diameter were also evaluated. In addition, the relationship between the most distal screw place and articular surface was confirmed with one case of distal radius fracture. Results The optimal positions relative to the neutral were 2.7 mm proximal in the distal swing and 1.9 mm distal in the proximal swing. The linear distance was significantly correlated with the transverse diameter in each group. It was confirmed that the relationship between the most distal screw place and articular surface was applicable in the actual case. Conclusion The results showed that the most distal position of the polyaxial VLP differed depending on the screw insertion angle and became more proximal as the transverse diameter increased. These results may be useful as a reference for preoperative planning. Levels of Evidence III.
rights: Thieme. All rights reserved.
has PII: JWS-D-23-00145
doi: 10.1055/s-0044-1782238
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Eda Y
      type: Person
      first name: Yusuke
      last name: Eda
      member of: Department of Orthopaedic Surgery, Tsukuba Medical Center, Tsukuba, Ibaraki, Japan.Department of Orthopaedic Surgery, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, Japan.
  slot:
    index: 2
    item: Kohyama S
      type: Person
      first name: Sho
      last name: Kohyama
      member of: Department of Orthopaedic Surgery, Kikkoman General Hospital, Noda, Chiba, Japan.
  slot:
    index: 3
    item: Ikumi A
      type: Person
      first name: Akira
      last name: Ikumi
      member of: Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  slot:
    index: 4
    item: Ishii T
      type: Person
      first name: Tomoo
      last name: Ishii
      member of: Department of Orthopaedic Surgery, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, Japan.
  slot:
    index: 5
    item: Yamazaki M
      type: Person
      first name: Masashi
      last name: Yamazaki
      member of: Department of Orthopaedic Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  slot:
    index: 6
    item: Yoshii Y
      type: Person
      first name: Yuichi
      last name: Yoshii
      member of: Department of Orthopaedic Surgery, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, Japan.
created: 2024-12-2T06:27
date last updated: 2025-03-09
issued: 2024-12
dp: 2024 Dec
created: 2024-12-2T05:19
ISSN: 2163-3916
has issn l: 2163-3916
issue: 6
has NLM journal title abbreviation: J Wrist Surg
publication name: Journal of wrist surgery
language: eng
has national library of medicine journal id: 101603430
derived from: NLM
starting page: 484
ending page: 491
has place of publication: United States
source: J Wrist Surg. 2024-12;13(6):484-491.
volume: 13

Novel ultrasound-based classification of retinal funnel patterns in stage 5 retinopathy of prematurity.
pmid: 39623107
has PII: 10.1038/s41433-024-03516-0
doi: 10.1038/s41433-024-03516-0
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Chandra P
      type: Person
      first name: Parijat
      last name: Chandra
      member of: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India. parijatchandra@gmail.com.
  slot:
    index: 2
    item: Gangwe A
      type: Person
      first name: Anil
      last name: Gangwe
      member of: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
  slot:
    index: 3
    item: Kumar V
      type: Person
      first name: Vivek
      last name: Kumar
      member of: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
created: 2024-12-3T00:23
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-12-2T23:39
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 793
ending page: 795
has place of publication: England
source: Eye (Lond). 2025-03;39(4):793-795.
volume: 39

PCSK9 levels and diabetic retinopathy: opportunities for a potential target and novel therapeutic approach in conjunction with treating dyslipidaemia.
pmid: 39623109
has PII: 10.1038/s41433-024-03523-1
doi: 10.1038/s41433-024-03523-1
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Varughese MS
      type: Person
      first name: Maria S
      last name: Varughese
      member of: University of Sheffield Medical School, Royal Hallamshire Hospital, Sheffield, UK.
  slot:
    index: 2
    item: Nayak AU
      type: Person
      first name: Ananth U
      last name: Nayak
      member of: University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, North Staffordshire, UK.School of Medicine, Faculty of Health, Keele University, Newcastle, North Staffordshire, UK.
  slot:
    index: 3
    item: Jacob S
      type: Person
      first name: Sarita
      last name: Jacob
      member of: University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Sarita.Jacob@uhb.nhs.uk.Institute of Clinical Sciences, University of Birmingham, Birmingham, UK. Sarita.Jacob@uhb.nhs.uk.College of Life and Health Sciences, Aston University, Birmingham, UK. Sarita.Jacob@uhb.nhs.uk.Birmingham, Solihull and Black Country Diabetic Eye Screening Programme, Birmingham, UK. Sarita.Jacob@uhb.nhs.uk.
created: 2024-12-3T00:23
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-12-2T23:39
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 628
ending page: 630
has place of publication: England
source: Eye (Lond). 2025-03;39(4):628-630.
volume: 39

Diffuse PRAME Expression in Transdifferentiated Melanomas.
pmid: 39625060
doi: 10.1111/cup.14769
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Hegazy S
      type: Person
      first name: Shaymaa
      last name: Hegazy
      member of: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  slot:
    index: 2
    item: Karunamurthy A
      type: Person
      first name: Arivarasan
      last name: Karunamurthy
      member of: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  slot:
    index: 3
    item: John I
      type: Person
      first name: Ivy
      last name: John
      member of: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
created: 2024-12-3T12:26
date last updated: 2025-03-09
issued: 2025-04
dp: 2025 Apr
created: 2024-12-3T06:53
e ISSN: 1600-0560
has issn l: 0303-6987
issue: 4
has NLM journal title abbreviation: J Cutan Pathol
publication name: Journal of cutaneous pathology
language: eng
has national library of medicine journal id: 0425124
derived from: NLM
starting page: 269
ending page: 271
has place of publication: United States
source: J Cutan Pathol. 2025-04;52(4):269-271.
volume: 52

Ophthalmology focus for the undergraduate student: a generic overview and outlook on global perspectives of experiential learning at medical schools.
pmid: 39623110
has PII: 10.1038/s41433-024-03521-3
doi: 10.1038/s41433-024-03521-3
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Varughese MS
      type: Person
      first name: Maria S
      last name: Varughese
      member of: University of Sheffield Medical School, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK.
  slot:
    index: 2
    item: Kalidindi S
      type: Person
      first name: Sushuma
      last name: Kalidindi
      member of: Department of Diabetes & Endocrinology, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK. Sushuma.Kalidindi@uhnm.nhs.uk.School of Medicine, Faculty of Health, Keele University, Newcastle, North Staffordshire, UK. Sushuma.Kalidindi@uhnm.nhs.uk.
created: 2024-12-3T00:22
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-12-2T23:39
e ISSN: 1476-5454
has issn l: 0950-222X
issue: 4
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
starting page: 624
ending page: 627
has place of publication: England
source: Eye (Lond). 2025-03;39(4):624-627.
volume: 39

Optimizing Ligand Valency to Maximize Tendon Accumulation of Peptide-Targeted Nanoparticles.
pmid: 39630483
abstract: In many tissues, including musculoskeletal tissues such as tendon, systemic delivery typically results in poor targeting of free drugs. Hence, we previously developed a targeted drug delivery nanoparticle (NP) system for tendon healing, leveraging a tartrate resistant acid phosphatase (TRAP) binding peptide (TBP) ligand. The greatest tendon targeting was observed with NPs functionalized with 30 000 TBP ligands per NP at day 7 during the proliferative healing phase, relative to the inflammatory (day 3) and early remodeling (day 14) phases of healing. Nevertheless, TRAP activity varies throughout healing and, therefore, may offer an opportunity for optimizing temporal therapeutic targeting through multivalent interactions. Hence, in this study, we hypothesized that the ligand density (9000-55,000 TBPs per NP) can optimize tendon accumulation on the basis of variable TRAP levels. The multivalent nanoparticles were loaded with three different fluorophores. In vitro, the ligand density and fluorophore had no effect on the physicochemical properties of the NPs, including size, charge, polydispersity index, or dye loading efficiency; however, the TRAP binding affinity correlated positively with the ligand density. In vivo, the ligand density correlated positively with NP homing and retention in the tendon, establishing opportunities to leverage ligand density for tendon targeting across the tendon healing cascade, during aging, and in other tendon pathologies, including tendinopathies.
doi: 10.1021/acsami.4c13388
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Adjei-Sowah E
      type: Person
      first name: Emmanuela
      last name: Adjei-Sowah
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, United States.
  slot:
    index: 2
    item: Rangasami V
      type: Person
      first name: Vigneshkumar
      last name: Rangasami
      member of: Department of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.
  slot:
    index: 3
    item: Loiselle AE
      type: Person
      first name: Alayna E
      last name: Loiselle
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, United States.Department of Orthopedics & Physical Performance, University of Rochester Medical Center, Rochester, New York 14642, United States.Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, United States.
  slot:
    index: 4
    item: Benoit DSW
      type: Person
      first name: Danielle S W
      last name: Benoit
      member of: Department of Biomedical Engineering, University of Rochester, Rochester, New York 14623, United States.Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, United States.Department of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon 97403, United States.Department of Orthopedics & Physical Performance, University of Rochester Medical Center, Rochester, New York 14642, United States.
created: 2024-12-4T12:30
date last updated: 2025-03-09
issued: 2024-12-18
dp: 2024 Dec 18
created: 2024-12-4T11:43
e ISSN: 1944-8252
has issn l: 1944-8244
issue: 50
has NLM journal title abbreviation: ACS Appl Mater Interfaces
publication name: ACS applied materials & interfaces
language: eng
has national library of medicine journal id: 101504991
derived from: NLM
starting page: 68864
ending page: 68876
has place of publication: United States
has primary subject term: D013710Q000187Q000378
has primary subject term: D053758Q000737
has primary subject term: D010455Q000737
has subject term: D000818
has subject term: D008024
has subject term: D000071681Q000378
has subject term: D008297
has subject term: D005456Q000737
has subject term: D051379
has subject term: D006801
has subject term: D051381
source: ACS Appl Mater Interfaces. 2024-12-18;16(50):68864-68876.
volume: 16

Coinfection with Dengue virus (DENV) serotypes 1 and 2 during a dengue outbreak in the state of Paraná, Brazil.
pmid: 39636573
has PII: 10.1007/s42770-024-01580-y
doi: 10.1007/s42770-024-01580-y
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Sato LS
      type: Person
      first name: Léo Shigueki
      last name: Sato
      member of: Graduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, Brazil. sshiguekisato@gmail.com.Laboratory of Clinical Virology, State University of Maringá, Maringá, Paraná, Brazil. sshiguekisato@gmail.com.
  slot:
    index: 2
    item: Castro Moreira D
      type: Person
      first name: Deborah de
      last name: Castro Moreira
      member of: Laboratory of Clinical Virology, State University of Maringá, Maringá, Paraná, Brazil.
  slot:
    index: 3
    item: Miyamoto SK
      type: Person
      first name: Sonia Kaori
      last name: Miyamoto
      member of: Laboratory of Clinical Virology, State University of Maringá, Maringá, Paraná, Brazil.15th Health Region, Paraná State Health Department, Maringá, Paraná, Brazil.
  slot:
    index: 4
    item: Lopes LDG
      type: Person
      first name: Luciana Dias Ghiraldi
      last name: Lopes
      member of: Laboratory of Clinical Virology, State University of Maringá, Maringá, Paraná, Brazil.Department of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil.
  slot:
    index: 5
    item: Bertolini DA
      type: Person
      first name: Dennis Armando
      last name: Bertolini
      member of: Laboratory of Clinical Virology, State University of Maringá, Maringá, Paraná, Brazil.Department of Clinical Analysis, State University of Maringá, Maringá, Paraná, Brazil.
created: 2024-12-5T17:32
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-12-5T11:20
e ISSN: 1678-4405
has issn l: 1517-8382
issue: 1
has NLM journal title abbreviation: Braz J Microbiol
publication name: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
language: eng
has national library of medicine journal id: 101095924
derived from: NLM
starting page: 313
ending page: 317
has place of publication: Brazil
source: Braz J Microbiol. 2025-03;56(1):313-317.
volume: 56

Rethinking public health in wartime: Smoking and long-term health outcomes amidst the war in Ukraine.
pmid: 39647697
has PII: S2213-5383(24)00066-3
doi: 10.1016/j.jcpo.2024.100532
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Koczkodaj P
      type: Person
      first name: Paweł
      last name: Koczkodaj
      member of: Department of Cancer Epidemiology and Primary Prevention, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. Electronic address: pawel.koczkodaj@nio.gov.pl.
  slot:
    index: 2
    item: Michalek IM
      type: Person
      first name: Irmina Maria
      last name: Michalek
      member of: Polish Onco-Hematology Registry, Polish National Cancer Registry, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
created: 2024-12-9T00:22
date last updated: 2025-03-08
issued: 2025-03
dp: 2025 Mar
created: 2024-12-8T19:16
e ISSN: 2213-5383
has issn l: 2213-5383
has NLM journal title abbreviation: J Cancer Policy
publication name: Journal of cancer policy
language: eng
has national library of medicine journal id: 101639933
derived from: NLM
pg: 100532
has place of publication: England
source: J Cancer Policy. 2025-03;43():100532.
volume: 43

Severe overlap of morphea and lichen sclerosus after anti-PD-L1 immunotherapy in small cell lung cancer.
pmid: 39648493
doi: 10.1111/ddg.15599
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Geidel G
      type: Person
      first name: Glenn
      last name: Geidel
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 2
    item: Menz A
      type: Person
      first name: Anne
      last name: Menz
      member of: Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 3
    item: Grotenrath FM
      type: Person
      first name: Franziska M
      last name: Grotenrath
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 4
    item: Rünger A
      type: Person
      first name: Alessandra
      last name: Rünger
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 5
    item: Kött J
      type: Person
      first name: Julian
      last name: Kött
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 6
    item: Schneider SW
      type: Person
      first name: Stefan W
      last name: Schneider
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 7
    item: Gebhardt C
      type: Person
      first name: Christoffer
      last name: Gebhardt
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 8
    item: Booken N
      type: Person
      first name: Nina
      last name: Booken
      member of: Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
created: 2024-12-9T06:17
date last updated: 2025-03-09
issued: 2025-03
dp: 2025 Mar
created: 2024-12-9T01:33
e ISSN: 1610-0387
has issn l: 1610-0379
issue: 3
has NLM journal title abbreviation: J Dtsch Dermatol Ges
publication name: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
language: eng
has national library of medicine journal id: 101164708
derived from: NLM
starting page: 378
ending page: 380
has place of publication: Germany
source: J Dtsch Dermatol Ges. 2025-03;23(3):378-380.
volume: 23

Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in Mice.
pmid: 39651120
abstract: The global prevalence of Metabolic dysfunction-associated steatohepatitis (MASH) has been rising sharply, closely mirroring the increasing rates of obesity and metabolic syndrome. MASH exhibits a strong sexual dimorphism where females are affected with more severe forms after menopause. Hexokinase domain-containing protein 1 (HKDC1) has recently been recognized for its role in liver diseases, where its expression is minimal under normal conditions but significantly increases in response to metabolic stressors like obesity and liver injury. This selective upregulation suggests HKDC1s potential specialization in hepatic glucose and lipid dysregulation, linking it closely to the progression of MASLD and MASH. This study aims to clarify the role of HKDC1 in Western diet-induced MASH in female mice by examining its impact on hepatic glucose and lipid metabolism, offering insights into its potential as a therapeutic target and addressing the need for sex-specific research in liver disease. This study reveals that HKDC1 expression is elevated in obese women with MASH and correlates with liver pathology. In a mouse model, liver-specific HKDC1 knockout (HKDC1LKO) protected against Western diet-induced obesity, glucose intolerance, and MASH features, including steatosis, inflammation, and fibrosis. Transcriptomic analysis showed that HKDC1 deletion reduced pro-inflammatory and pro-fibrotic gene expression, while gut microbiome analysis indicated a shift toward MASH-protective bacteria. These findings suggest that HKDC1 may exacerbate MASH progression through its role in metabolic and inflammatory pathways, making it a potential therapeutic target.
doi: 10.1101/2024.11.26.625530
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Xu K
      type: Person
      first name: Kai
      last name: Xu
  slot:
    index: 2
    item: Corona-Avila I
      type: Person
      first name: Irene
      last name: Corona-Avila
  slot:
    index: 3
    item: Frutos MD
      type: Person
      first name: Maria Dolores
      last name: Frutos
  slot:
    index: 4
    item: Nunez-Sanchez MA
      type: Person
      first name: Maria Angeles
      last name: Nunez-Sanchez
  slot:
    index: 5
    item: Makhanasa D
      type: Person
      first name: Dhruvi
      last name: Makhanasa
  slot:
    index: 6
    item: Shah PV
      type: Person
      first name: Pratham Viral
      last name: Shah
  slot:
    index: 7
    item: Guzman G
      type: Person
      first name: Grace
      last name: Guzman
  slot:
    index: 8
    item: Ramos-Molina B
      type: Person
      first name: Bruno
      last name: Ramos-Molina
  slot:
    index: 9
    item: Priyadarshini M
      type: Person
      first name: Medha
      last name: Priyadarshini
  slot:
    index: 10
    item: Khan MW
      type: Person
      first name: Md Wasim
      last name: Khan
created: 2024-12-9T17:33
date last updated: 2025-03-08
issued: 2025-02-27
dp: 2025 Feb 27
created: 2024-12-9T06:23
e ISSN: 2692-8205
has issn l: 2692-8205
has NLM journal title abbreviation: bioRxiv
publication name: bioRxiv : the preprint server for biology
language: eng
has national library of medicine journal id: 101680187
derived from: NLM
has place of publication: United States
source: bioRxiv. 2025-02-27;():.

Adolescent choices and caregiver roles: Understanding individual and interpersonal influences on sexual decision-making in South Africa.
pmid: 39652556
abstract: South African adolescents are at-risk for HIV infection due to engaging in high-risk sexual behaviours. Understanding the factors influencing sexual decision-making is crucial for developing effective HIV prevention strategies. We conducted a qualitative study with adolescents and caregivers in Rustenburg, South Africa to explore individual and interpersonal factors that influence adolescent sexual decision-making. Focus Group Discussions (FGDs) were conducted in English and Setswana with 17 adolescents (13 females and 4 males) and 19 caregivers (17 females and 2 males) between April and July 2018. Thematic analysis revealed that while adolescents had access to sexual education from various sources, this knowledge did not translate into healthy sexual decision-making. Lack of effective communication and support between caregivers and adolescents in discussing sexual behaviours are a contributing barrier. Although adolescents expressed a strong need to be understood and supported by caregivers regarding sexual behaviours, there was perceived distrust, judgemental attitude from caregivers, poor role models of a father figure, and the traditional taboo nature of having these discussions with caregivers. While female adolescents and female caregivers discussed sexual matters, this type of communication was limited with adolescent males. Male adolescents were uncomfortable communicating with either caregiver, fearing caregiver judgemental attitudes and being misunderstood. Female caregivers perceived male caregiver roles to be absent and non-engaging. Caregivers desired to support their children, yet they seemed to doubt their skills. Communication tools and guidance on how adolescents and caregivers could communicate about sexual matters could create enabling environments for adolescents to make informed, healthy decisions regarding their sexual behaviours. Further, future interventions could consider gain-framed messaging to address adolescents translating knowledge of[cell cut: 2205 characters, first 2000 kept]
rights: Copyright: © 2024 Makkan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PGPH-D-24-01646
doi: 10.1371/journal.pgph.0003569
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Makkan H
      type: Person
      first name: Heeran
      last name: Makkan
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.Department of Interdisciplinary Social Science, Public Health, Utrecht University, Utrecht, The Netherlands.
  slot:
    index: 2
    item: Wangui Machira Y
      type: Person
      first name: Yvonne
      last name: Wangui Machira
      member of: IAVI Africa, Nairobi, Kenya.
  slot:
    index: 3
    item: Mthembu F
      type: Person
      first name: Funeka
      last name: Mthembu
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.
  slot:
    index: 4
    item: Masibi O
      type: Person
      first name: Omphile
      last name: Masibi
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.
  slot:
    index: 5
    item: Molefe T
      type: Person
      first name: Thuso
      last name: Molefe
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.
  slot:
    index: 6
    item: Maenetje P
      type: Person
      first name: Pholo
      last name: Maenetje
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
  slot:
    index: 7
    item: Muturi-Kioi V
      type: Person
      first name: Vincent
      last name: Muturi-Kioi
      member of: IAVI Africa, Nairobi, Kenya.
  slot:
    index: 8
    item: Price MA
      type: Person
      first name: Matt A
      last name: Price
      member of: IAVI Africa, Nairobi, Kenya.Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, United States of America.
  slot:
    index: 9
    item: Edward VA
      type: Person
      first name: Vinodh Aroon
      last name: Edward
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.Department of Interdisciplinary Social Science, Public Health, Utrecht University, Utrecht, The Netherlands.Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.School of Health Sciences, College of Health Sciences, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 10
    item: Chetty-Makkan C
      type: Person
      first name: Candice
      last name: Chetty-Makkan
      member of: The Aurum Institute, Rustenburg Research Centre, Rustenburg, South Africa.Health Economics and Epidemiology Research Office (HE2RO), Wits Health Consortium, Johannesburg, South Africa.Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
created: 2024-12-9T18:26
date last updated: 2025-03-09
issued: 2024
dp: 2024
created: 2024-12-9T13:34
e ISSN: 2767-3375
has issn l: 2767-3375
issue: 12
has NLM journal title abbreviation: PLOS Glob Public Health
publication name: PLOS global public health
language: eng
has national library of medicine journal id: 9918283779606676
derived from: NLM
pg: e0003569
has place of publication: United States
source: PLOS Glob Public Health. 2024;4(12):e0003569.
volume: 4

Constrained β-Hairpins Targeting the EphA4 Ligand Binding Domain.
pmid: 39656022
abstract: The activity of the receptor tyrosine kinase EphA4 has been implicated in several pathologies including oncology (gastric and pancreatic cancers) and neurodegenerative diseases (amyotrophic lateral sclerosis and Alzheimer's disease). However, advances in validating EphA4 as a possible drug target have been limited by the lack of suitable pharmacological inhibitors. Recently, we reported on the design of potent EphA4 agonistic agents targeting its ligand binding domain (LBD). Based on previous studies with a phage display cyclic peptide inhibitor, we designed a β-hairpin mimetic with high affinity for EphA4-LBD. These agents hold great promise for further validation and development of EphA4-based therapeutics. Moreover, our studies introduce a possible strategy for the design of constrained β-hairpin peptides.
doi: 10.1021/acs.jmedchem.4c02286
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Prentiss AM
      type: Person
      first name: Anne Marie
      last name: Prentiss
      member of: Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States.
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      type: Person
      first name: Carlo
      last name: Baggio
      member of: Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States.
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    item: Pagett J
      type: Person
      first name: James
      last name: Pagett
      member of: Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States.
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    item: Kulinich AO
      type: Person
      first name: Anna O
      last name: Kulinich
      member of: Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States.
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    item: Ethell IM
      type: Person
      first name: Iryna M
      last name: Ethell
      member of: Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States.
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    item: Muzzarelli K
      type: Person
      first name: Kendall
      last name: Muzzarelli
      member of: Cayman Chemical Co., 1180 E. Ellsworth Road, Ann Arbor, Michigan 48108, United States.
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    item: Assar Z
      type: Person
      first name: Zahra
      last name: Assar
      member of: Cayman Chemical Co., 1180 E. Ellsworth Road, Ann Arbor, Michigan 48108, United States.
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    item: Pellecchia M
      type: Person
      first name: Maurizio
      last name: Pellecchia
      member of: Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States.
created: 2024-12-10T12:27
date last updated: 2025-03-09
issued: 2024-12-26
dp: 2024 Dec 26
created: 2024-12-10T09:14
e ISSN: 1520-4804
has issn l: 0022-2623
issue: 24
has NLM journal title abbreviation: J Med Chem
publication name: Journal of medicinal chemistry
language: eng
has national library of medicine journal id: 9716531
derived from: NLM
starting page: 22245
ending page: 22253
has place of publication: United States
has primary subject term: D036122Q000378Q000037Q000737
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has subject term: D008958
source: J Med Chem. 2024-12-26;67(24):22245-22253.
volume: 67

http://rdf.ncbi.nlm.nih.gov/pubmed/39662225
pmid: 39662225
has PII: S1201-9712(24)00397-7
doi: 10.1016/j.ijid.2024.107322
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    item: Watase M
      type: Person
      first name: Mayuko
      last name: Watase
      member of: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
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    item: Masaki K
      type: Person
      first name: Katsunori
      last name: Masaki
      member of: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: masakik@keio.jp.
creator: Japan COVID-19 Task Force
created: 2024-12-12T00:24
date last updated: 2025-03-09
issued: 2025-02
dp: 2025 Feb
created: 2024-12-11T18:36
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has issn l: 1201-9712
has NLM journal title abbreviation: Int J Infect Dis
publication name: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
language: eng
has national library of medicine journal id: 9610933
derived from: NLM
pg: 107322
has place of publication: Canada
source: Int J Infect Dis. 2025-02;151():107322.
title: Corrigendum to 'Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force' [IJID 128 (2023) 121-127].
volume: 151

index: 29
item: Blennow K
  type: Person
  first name: Kaj
  last name: Blennow
  member of: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

index: 30
item: Blesa R
  type: Person
  first name: Rafael
  last name: Blesa
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

index: 31
item: Boada M
  type: Person
  first name: Mercè
  last name: Boada
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 32
item: Boland A
  type: Person
  first name: Anne
  last name: Boland
  member of: Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France.

index: 33
item: Buerger K
  type: Person
  first name: Katharina
  last name: Buerger
  member of: German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

index: 34
item: Carracedo Á
  type: Person
  first name: Ángel
  last name: Carracedo
  member of: Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS, Santiago de Compostela, Spain.

index: 35
item: Cervera-Carles L
  type: Person
  first name: Laura
  last name: Cervera-Carles
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

index: 36
item: Chene G
  type: Person
  first name: Geneviève
  last name: Chene
  member of: University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.Department of Neurology, CHU de Bordeaux, 33000, Bordeaux, France.

index: 37
item: Claassen JAHR
  type: Person
  first name: Jurgen A H R
  last name: Claassen
  member of: Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, The Netherlands.Donders Center for Medical Neuroscience, Nijmegen, The Netherlands.

index: 38
item: Debette S
  type: Person
  first name: Stephanie
  last name: Debette
  member of: University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.Department of Neurology, CHU de Bordeaux, 33000, Bordeaux, France.Department of Neurology, Boston University School of Medicine, Boston, MA, 2115, USA.

index: 39
item: Deleuze JF
  type: Person
  first name: Jean-Francois
  last name: Deleuze
  member of: Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France.

index: 40
item: de Deyn PP
  type: Person
  first name: Peter Paul
  last name: de Deyn
  member of: Department of Neurology and Alzheimer Center Groningen, University Medical Center Groningen, Groningen, The Netherlands.

index: 41
item: Diehl-Schmid J
  type: Person
  first name: Janine
  last name: Diehl-Schmid
  member of: Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.kbo-Inn-Salzach-Hospital, Wasserburg am Inn, Germany.

index: 42
item: Djurovic S
  type: Person
  first name: Srdjan
  last name: Djurovic
  member of: Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.Department of Clinical Science, NORMENT Centre, University of Bergen, Bergen, Norway.

index: 43
item: Dols-Icardo O
  type: Person
  first name: Oriol
  last name: Dols-Icardo
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

index: 44
item: Dufouil C
  type: Person
  first name: Carole
  last name: Dufouil
  member of: University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.Pôle de Santé Publique Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.

index: 45
item: Duron E
  type: Person
  first name: Emmanuelle
  last name: Duron
  member of: Univerisité Paris-Saclay. Inserm 1178 MOODS, Paris, France.

index: 46
item: Düzel E
  type: Person
  first name: Emrah
  last name: Düzel
  member of: German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.

index: 47
item: Fladby T
  type: Person
  first name: Tormod
  last name: Fladby
  member of: Institute of Clinical Medicine, University of Oslo, Oslo, Norway.Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

index: 48
item: Fortea J
  type: Person
  first name: Juan
  last name: Fortea
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

index: 49
item: Frölich L
  type: Person
  first name: Lutz
  last name: Frölich
  member of: Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg, Germany.

index: 50
item: García-González P
  type: Person
  first name: Pablo
  last name: García-González
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 51
item: Garcia-Martinez M
  type: Person
  first name: Maria
  last name: Garcia-Martinez
  member of: Cognitive Impairment Unit, Neurology Service, Marqués de Valdecilla University Hospital, Institute for Research Marques de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

index: 52
item: Giegling I
  type: Person
  first name: Ina
  last name: Giegling
  member of: Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

index: 53
item: Goldhardt O
  type: Person
  first name: Oliver
  last name: Goldhardt
  member of: Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

index: 54
item: Gobom J
  type: Person
  first name: Johan
  last name: Gobom
  member of: Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

index: 55
item: Grimmer T
  type: Person
  first name: Timo
  last name: Grimmer
  member of: Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

index: 56
item: Haapasalo A
  type: Person
  first name: Annakaisa
  last name: Haapasalo
  member of: A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

index: 57
item: Hampel H
  type: Person
  first name: Harald
  last name: Hampel
  member of: Alzheimer Precision Medicine (APM), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.Neurology Business Group, Eisai Inc, 100 Tice Blvd, Woodcliff Lake, NJ, 07677, USA.

index: 58
item: Hanon O
  type: Person
  first name: Olivier
  last name: Hanon
  member of: Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.Service gériatrie, Centre Mémoire de Ressources et Recherches Ile de France-Broca, AP-HP, Hôpital Broca, F-75013, Paris, France.

index: 59
item: Hausner L
  type: Person
  first name: Lucrezia
  last name: Hausner
  member of: Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg, Germany.

index: 60
item: Heilmann-Heimbach S
  type: Person
  first name: Stefanie
  last name: Heilmann-Heimbach
  member of: Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, 53127, Bonn, Germany.

index: 61
item: Helisalmi S
  type: Person
  first name: Seppo
  last name: Helisalmi
  member of: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.

index: 62
item: Heneka MT
  type: Person
  first name: Michael T
  last name: Heneka
  member of: Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

index: 63
item: Hernández I
  type: Person
  first name: Isabel
  last name: Hernández
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 64
item: Herukka SK
  type: Person
  first name: Sanna-Kaisa
  last name: Herukka
  member of: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

index: 65
item: Holstege H
  type: Person
  first name: Henne
  last name: Holstege
  member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.

index: 66
item: Jarholm J
  type: Person
  first name: Jonas
  last name: Jarholm
  member of: Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

index: 67
item: Kern S
  type: Person
  first name: Silke
  last name: Kern
  member of: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

index: 68
item: Knapskog AB
  type: Person
  first name: Anne-Brita
  last name: Knapskog
  member of: Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

index: 69
item: Koivisto AM
  type: Person
  first name: Anne M
  last name: Koivisto
  member of: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.Department of Neurology, Kuopio University Hospital, Kuopio, Finland.Department of Neurology, Helsinki University Hospital, Helsinki, Finland.

index: 70
item: Kornhuber J
  type: Person
  first name: Johannes
  last name: Kornhuber
  member of: Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

index: 71
item: Kuulasmaa T
  type: Person
  first name: Teemu
  last name: Kuulasmaa
  member of: Bioinformatics Center, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

index: 72
item: Lage C
  type: Person
  first name: Carmen
  last name: Lage
  member of: Cognitive Impairment Unit, Neurology Service, Marqués de Valdecilla University Hospital, Institute for Research Marques de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.Atlantic Fellow at the Global Brain Health Institute (GBHI) -, University of California, San Francisco, USA.

index: 73
item: Laske C
  type: Person
  first name: Christoph
  last name: Laske
  member of: German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

index: 74
item: Leinonen V
  type: Person
  first name: Ville
  last name: Leinonen
  member of: Institute of Clinical Medicine, Neurosurgery, University of Eastern Finland, Kuopio, Finland.Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland.

index: 75
item: Lewczuk P
  type: Person
  first name: Piotr
  last name: Lewczuk
  member of: Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland.

index: 76
item: Lleó A
  type: Person
  first name: Alberto
  last name: Lleó
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

index: 77
item: de Munain AL
  type: Person
  first name: Adolfo López
  last name: de Munain
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Hospital Universitario Donostia-OSAKIDETZA, Donostia, Spain.Instituto Biodonostia, San Sebastián, Spain.University of The Basque Country, San Sebastian, Spain.

index: 78
item: Lopez-Garcia S
  type: Person
  first name: Sara
  last name: Lopez-Garcia
  member of: Cognitive Impairment Unit, Neurology Service, Marqués de Valdecilla University Hospital, Institute for Research Marques de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

index: 79
item: Maier W
  type: Person
  first name: Wolfgang
  last name: Maier
  member of: Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.

index: 80
item: Marquié M
  type: Person
  first name: Marta
  last name: Marquié
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 81
item: Mol MO
  type: Person
  first name: Merel O
  last name: Mol
  member of: Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

index: 82
item: Montrreal L
  type: Person
  first name: Laura
  last name: Montrreal
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.

index: 83
item: Moreno F
  type: Person
  first name: Fermin
  last name: Moreno
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Hospital Universitario Donostia-OSAKIDETZA, Donostia, Spain.Instituto Biodonostia, San Sebastián, Spain.

index: 84
item: Moreno-Grau S
  type: Person
  first name: Sonia
  last name: Moreno-Grau
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 85
item: Nicolas G
  type: Person
  first name: Gael
  last name: Nicolas
  member of: Department of Genetics and CNR-MAJ, Normandie Univ, UNIROUEN, Inserm U1245 and CHU Rouen, Rouen, France.

index: 86
item: Nöthen MM
  type: Person
  first name: Markus M
  last name: Nöthen
  member of: Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, 53127, Bonn, Germany.

index: 87
item: Orellana A
  type: Person
  first name: Adelina
  last name: Orellana
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 88
item: Pålhaugen L
  type: Person
  first name: Lene
  last name: Pålhaugen
  member of: Institute of Clinical Medicine, University of Oslo, Oslo, Norway.Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

index: 89
item: Papma JM
  type: Person
  first name: Janne M
  last name: Papma
  member of: Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

index: 90
item: Pasquier F
  type: Person
  first name: Florence
  last name: Pasquier
  member of: Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.

index: 91
item: Perneczky R
  type: Person
  first name: Robert
  last name: Perneczky
  member of: German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.

index: 92
item: Peters O
  type: Person
  first name: Oliver
  last name: Peters
  member of: German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.

index: 93
item: Pijnenburg YAL
  type: Person
  first name: Yolande A L
  last name: Pijnenburg
  member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.

index: 94
item: Popp J
  type: Person
  first name: Julius
  last name: Popp
  member of: Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich and University of Zürich, Zurich, Switzerland.Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.

index: 95
item: Posthuma D
  type: Person
  first name: Danielle
  last name: Posthuma
  member of: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.

index: 96
item: Pozueta A
  type: Person
  first name: Ana
  last name: Pozueta
  member of: Cognitive Impairment Unit, Neurology Service, Marqués de Valdecilla University Hospital, Institute for Research Marques de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

index: 97
item: Priller J
  type: Person
  first name: Josef
  last name: Priller
  member of: German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.Department of Psychiatry and Psychotherapy, Klinikum rechts der isar, Technical University Munich, 81675, Munich, Germany.

index: 98
item: Puerta R
  type: Person
  first name: Raquel
  last name: Puerta
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.

index: 99
item: Quintela I
  type: Person
  first name: Inés
  last name: Quintela
  member of: Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

index: 100
item: Ramakers I
  type: Person
  first name: Inez
  last name: Ramakers
  member of: Department of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.

index: 101
item: Rodriguez-Rodriguez E
  type: Person
  first name: Eloy
  last name: Rodriguez-Rodriguez
  member of: Cognitive Impairment Unit, Neurology Service, Marqués de Valdecilla University Hospital, Institute for Research Marques de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

index: 102
item: Rujescu D
  type: Person
  first name: Dan
  last name: Rujescu
  member of: Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

index: 103
item: Saltvedt I
  type: Person
  first name: Ingvild
  last name: Saltvedt
  member of: Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.Department of Geriatrics, St Olav Hospital, University Hospital of Trondheim, Trondheim, Norway.

index: 104
item: Sanchez-Juan P
  type: Person
  first name: Pascual
  last name: Sanchez-Juan
  member of: Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, 28031, Madrid, Spain.

index: 105
item: Scheltens P
  type: Person
  first name: Philip
  last name: Scheltens
  member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.

index: 106
item: Scherbaum N
  type: Person
  first name: Norbert
  last name: Scherbaum
  member of: Department of Psychiatry and Psychotherapy, Medical Faculty, LVR-Hospital Essen, University of Duisburg-Essen, Essen, Germany.

index: 107
item: Schmid M
  type: Person
  first name: Matthias
  last name: Schmid
  member of: Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.

index: 108
item: Schneider A
  type: Person
  first name: Anja
  last name: Schneider
  member of: Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

index: 109
item: Selbæk G
  type: Person
  first name: Geir
  last name: Selbæk
  member of: Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.Institute of Clinical Medicine, University of Oslo, Oslo, Norway.Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

index: 110
item: Selnes P
  type: Person
  first name: Per
  last name: Selnes
  member of: Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

index: 111
item: Shadrin A
  type: Person
  first name: Alexey
  last name: Shadrin
  member of: NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.

index: 112
item: Skoog I
  type: Person
  first name: Ingmar
  last name: Skoog
  member of: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

index: 113
item: Soininen H
  type: Person
  first name: Hilkka
  last name: Soininen
  member of: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

index: 114
item: Tárraga L
  type: Person
  first name: Lluís
  last name: Tárraga
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 115
item: Teipel S
  type: Person
  first name: Stefan
  last name: Teipel
  member of: German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.

index: 116
item: Tijms B
  type: Person
  first name: Betty
  last name: Tijms
  member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.

index: 117
item: Tsolaki M
  type: Person
  first name: Magda
  last name: Tsolaki
  member of: 1st Department of Neurology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Makedonia, Greece.

index: 118
item: Van Broeckhoven C
  type: Person
  first name: Christine
  last name: Van Broeckhoven
  member of: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.

index: 119
item: Van Dongen J
  type: Person
  first name: Jasper
  last name: Van Dongen
  member of: Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

index: 120
item: van Swieten JC
  type: Person
  first name: John C
  last name: van Swieten
  member of: Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

index: 121
item: Vandenberghe R
  type: Person
  first name: Rik
  last name: Vandenberghe
  member of: Neurology, University Hospitals Leuven, Leuven, Belgium.Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.

index: 122
item: Vidal JS
  type: Person
  first name: Jean-Sébastien
  last name: Vidal
  member of: Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.

index: 123
item: Visser PJ
  type: Person
  first name: Pieter J
  last name: Visser
  member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, The Netherlands.Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics Karolinska Institutet, Stockholm, Sweden.

index: 124
item: Vogelgsang J
  type: Person
  first name: Jonathan
  last name: Vogelgsang
  member of: Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Göttingen, Germany.Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.

index: 125
item: Waern M
  type: Person
  first name: Margda
  last name: Waern
  member of: Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Psychosis Clinic, Gothenburg, Sweden.

index: 126
item: Wagner M
  type: Person
  first name: Michael
  last name: Wagner
  member of: Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

index: 127
item: Wiltfang J
  type: Person
  first name: Jens
  last name: Wiltfang
  member of: Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Göttingen, Germany.German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.Medical Science Department, iBiMED, Aveiro, Portugal.

index: 128
item: Wittens MMJ
  type: Person
  first name: Mandy M J
  last name: Wittens
  member of: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

index: 129
item: Zetterberg H
  type: Person
  first name: Henrik
  last name: Zetterberg
  member of: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.UK Dementia Research Institute at UCL, London, UK.Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.

index: 130
item: Zulaica M
  type: Person
  first name: Miren
  last name: Zulaica
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Hospital Universitario Donostia-OSAKIDETZA, Donostia, Spain.Instituto Biodonostia, San Sebastián, Spain.

index: 131
item: van Duijn CM
  type: Person
  first name: Cornelia M
  last name: van Duijn
  member of: Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.Nuffield Department of Population Health, Oxford University, Oxford, UK.

index: 132
item: Bjerke M
  type: Person
  first name: Maria
  last name: Bjerke
  member of: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.Laboratory of Neurochemistry, Universitair Ziekenhuis Brussel, Brussels, Belgium.

index: 133
item: Engelborghs S
  type: Person
  first name: Sebastiaan
  last name: Engelborghs
  member of: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.Laboratory of Neurochemistry, Universitair Ziekenhuis Brussel, Brussels, Belgium.Department of Neurology, Universitair Ziekenhuis Brussel, Brussels, Belgium.

index: 134
item: Jessen F
  type: Person
  first name: Frank
  last name: Jessen
  member of: German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

index: 135
item: Teunissen CE
  type: Person
  first name: Charlotte E
  last name: Teunissen
  member of: Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.Neurochemistry Lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

index: 136
item: Pastor P
  type: Person
  first name: Pau
  last name: Pastor
  member of: Unit of Neurodegenerative diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain.

index: 137
item: Hiltunen M
  type: Person
  first name: Mikko
  last name: Hiltunen
  member of: Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

index: 138
item: Ingelsson M
  type: Person
  first name: Martin
  last name: Ingelsson
  member of: Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.

index: 139
item: Andreassen OA
  type: Person
  first name: Ole A
  last name: Andreassen
  member of: NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.Addiction, Oslo University Hospital, 0407, Oslo, Norway.

index: 140
item: Clarimón J
  type: Person
  first name: Jordi
  last name: Clarimón
  member of: CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

index: 141
item: Sleegers K
  type: Person
  first name: Kristel
  last name: Sleegers
  member of: Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

index: 142
item: Ruiz A
  type: Person
  first name: Agustín
  last name: Ruiz
  member of: Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

index: 143
item: Ramirez A
  type: Person
  first name: Alfredo
  last name: Ramirez
  member of: Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.Department of Psychiatry, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.

index: 144
item: Cruchaga C
  type: Person
  first name: Carlos
  last name: Cruchaga
  member of: Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.

index: 145
item: Lambert JC
  type: Person
  first name: Jean-Charles
  last name: Lambert
  member of: Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.

index: 146
item: van der Flier W
  type: Person
  first name: Wiesje
  last name: van der Flier
  member of: Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. wm.vdflier@amsterdamumc.nl.Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. wm.vdflier@amsterdamumc.nl.

index: 29
item: Spergel JM
  type: Person
  first name: Jonathan M
  last name: Spergel
  member of: Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

index: 30
item: Szajewska H
  type: Person
  first name: Hania
  last name: Szajewska
  member of: Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland.

index: 31
item: Terracciano L
  type: Person
  first name: Luigi
  last name: Terracciano
  member of: Pediatric Primary Care, National Pediatric Health Care System, Milan, Italy.

index: 32
item: Vandenplas Y
  type: Person
  first name: Yvan
  last name: Vandenplas
  member of: Department of Pediatric Gastroenterology, Universitair Ziekenhuis Brussel, Brussels, Belgium.

index: 33
item: Venter C
  type: Person
  first name: Carina
  last name: Venter
  member of: Section of Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.

index: 34
item: Waffenschmidt S
  type: Person
  first name: Siw
  last name: Waffenschmidt
  member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Institute for Quality and Efficiency in Health Care, Cologne, Germany.

index: 35
item: Waserman S
  type: Person
  first name: Susan
  last name: Waserman
  member of: Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.

index: 36
item: Warner A
  type: Person
  first name: Amena
  last name: Warner
  member of: Allergy UK, London, England, UK.

index: 37
item: Wong GWK
  type: Person
  first name: Gary W K
  last name: Wong
  member of: Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong.

index: 38
item: Schünemann HJ
  type: Person
  first name: Holger J
  last name: Schünemann
  member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Department of Biomedical Sciences, Humanitas University, Milan, Italy.Department of Medicine, Division of Internal Medicine, McMaster University, Hamilton, Ontario, Canada.

index: 39
item: Brozek JL
  type: Person
  first name: Jan L
  last name: Brozek
  member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.

index: 17
item: Said M
  type: Person
  first name: Maria
  last name: Said
  member of: Allergy & Anaphylaxis Australia (AAA), Castle Hill, New South Wales, Australia.

index: 18
item: Sánchez-Borges M
  type: Person
  first name: Mario
  last name: Sánchez-Borges
  member of: Allergy and Clinical Immunology Department, Centro Médico - Docente La Trinidad and Clínica El Avila, Caracas, Venezuela.

index: 19
item: Schunemann H
  type: Person
  first name: Holger
  last name: Schunemann
  member of: McMaster's University, Hamilton, Ontario, Canada.Cochrane Canada and McMaster University GRADE Center, Hamilton, Ontario, Canada.

index: 20
item: Shamir R
  type: Person
  first name: Raanan
  last name: Shamir
  member of: Institute for Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center, Lea and Arieh Pickel Chair for Pediatric Research, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.

index: 21
item: Spergel J
  type: Person
  first name: Jonathan
  last name: Spergel
  member of: Division of Allergy-Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.

index: 22
item: Szajewska H
  type: Person
  first name: Hania
  last name: Szajewska
  member of: Department of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw, Poland.

index: 23
item: Terracciano L
  type: Person
  first name: Luigi
  last name: Terracciano
  member of: Pediatric Primary Care, National Pediatric Health Care System, Milan, Italy.

index: 24
item: Vandenplas Y
  type: Person
  first name: Yvan
  last name: Vandenplas
  member of: KidZ Health Castle, Department of Pediatrics UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

index: 25
item: Waserman S
  type: Person
  first name: Susan
  last name: Waserman
  member of: Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

index: 26
item: Warner A
  type: Person
  first name: Amena
  last name: Warner
  member of: Allergy UK, London, England, UK.

index: 27
item: Wong GW
  type: Person
  first name: Gary Wk
  last name: Wong
  member of: Department of Paediatrics, Faculty of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China.

index: 29
item: Dupont C
  type: Person
  first name: Christophe
  last name: Dupont
  member of: Clinique Marcel Sembat, Ramsay Group, Boulogne-Billancourt, France.

index: 30
item: Bahna S
  type: Person
  first name: Sami
  last name: Bahna
  member of: Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA, USA.

index: 31
item: Spergel J
  type: Person
  first name: Jonathan
  last name: Spergel
  member of: Division of Allergy and Immunology, Children's Hospital of Philadelphia, USA.Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.

index: 32
item: Venter C
  type: Person
  first name: Carina
  last name: Venter
  member of: Section of Allergy and Clinical Immunology, University of Colorado, USA.Children's Hospital Colorado. Denver, Colorado, USA.

index: 33
item: Szajewska H
  type: Person
  first name: Hania
  last name: Szajewska
  member of: Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.

index: 34
item: Nowak-Wegrzyn AH
  type: Person
  first name: Anna H
  last name: Nowak-Wegrzyn
  member of: Department of Pediatrics, Hassenfeld Children's Hospital, New York University, Grossman School of Medicine, New York, NY, USA.Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.

index: 35
item: Vandenplas Y
  type: Person
  first name: Yvan
  last name: Vandenplas
  member of: Vrije Universiteit Brussel (VUB), UZ Brussel, Belgium.KidZ Health Castle, Brussels, Belgium.

index: 36
item: Papadopoulos NG
  type: Person
  first name: Nikolaos G
  last name: Papadopoulos
  member of: Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.Lydia Becker Institute, University of Manchester, Manchester, United Kingdom.

index: 37
item: Waserman S
  type: Person
  first name: Susan
  last name: Waserman
  member of: Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.

index: 38
item: Fiocchi A
  type: Person
  first name: Alessandro
  last name: Fiocchi
  member of: Translational Research in Pediatric Specialties Area, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

index: 39
item: Schünemann HJ
  type: Person
  first name: Holger J
  last name: Schünemann
  member of: Clinical Epidemiology and Research Center (CERC), Humanitas University & Humanitas Research Hospital, Pieve Emanuele, Milano, Italy.

index: 40
item: Brożek JL
  type: Person
  first name: Jan L
  last name: Brożek
  member of: Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.