The relation between respiratory symptoms and the range of tobacco product use among US adolescents/young adults is not yet clear. This cross-sectional analysis examines tobacco product use and respiratory symptoms in a nationally representative sample of 21,057 adolescents/young adults aged 12-24 years from Wave 4 (2016-17) of the Population Assessment of Tobacco and Health Study.Presence of functionally important respiratory symptoms was defined by questions regarding wheezing and nighttime cough at a cutoff score associated with poorer functional health status. Past-30-day tobacco use was analyzed 2 ways: never-tobacco users (reference) versus combustible users, noncombustible-only users, and former users; or frequency of use of cigarettes and/or e-cigarettes. Weighted Poisson regression adjusted for past-30-day marijuana use, secondhand smoke exposure, and asthma.Functionally important respiratory symptoms were present in 10.0% overall: 13.8% of combustible users, 9.0% of noncombustible users, 8.2% of noncurrent users and 9.7% of never users. Functionally important respiratory symptoms were associated with combustible tobacco use (relative risk [RR] = 1.52[95% CI 1.29, 1.80]), marijuana use (RR = 1.54[1.34, 1.77]) and secondhand smoke exposure (RR = 1.04[1.03, 1.05]). Higher cigarette smoking frequency was also associated with functionally important respiratory symptoms for frequency categories >14 days/month (eg, RR = 1.93[1.50, 2.49] for 15-29 days/month). Frequency of e-cigarette use was not associated with functionally important respiratory symptoms.During 2016-17, smoking cigarettes, marijuana use, and secondhand smoke exposure were cross-sectionally associated with functionally important respiratory symptoms in adolescents/young adults. Risk increased with increased frequency of cigarette use but not e-cigarette use. Given changes to contemporary e-cigarettes and use, findings may not generalize to newer products.
Copyright © 2022 Academic Pediatric Association. All rights reserved.
Geisel School of Medicine (S Tanski, J Emond, M Brunette, and J Sargent), Hanover, NH; The C. Everett Koop Institute at Dartmouth (S Tanski, J Emond, S Woloshin, M Brunette, L Schwartz, and J Sargent), Lebanon, NH. Electronic address: Susanne.E.Tanski@Dartmouth.edu.
Westat (MJ Halenar, KC Edwards, and KA Taylor), Rockville, MD.
Geisel School of Medicine (S Tanski, J Emond, M Brunette, and J Sargent), Hanover, NH; The C. Everett Koop Institute at Dartmouth (S Tanski, J Emond, S Woloshin, M Brunette, L Schwartz, and J Sargent), Lebanon, NH.
The C. Everett Koop Institute at Dartmouth (S Tanski, J Emond, S Woloshin, M Brunette, L Schwartz, and J Sargent), Lebanon, NH; Dartmouth Institute for Health Policy and Clinical Practice (S Woloshin and L Schwartz), Lebanon, NH; The Lisa Schwartz Foundation (S Woloshin, L Schwartz), Hanover, NH.
Roswell Park Comprehensive Cancer Center (ML Goniewicz and A Hyland), Buffalo, NY.
New York University (R Niaura), New York, NY.
U.S. Food and Drug Administration, Center for Tobacco Products (G Anic, Y Chen, P Callahan-Lyon, LD Gardner, T Thekkudan, and N Borek), Beltsville, Md.
National Institute on Drug Abuse, National Institutes of Health (HL Kimmel), Bethesda, Md.
Medical University of South Carolina (KM Cummings), Charleston, SC.
Tobacco Product Use and Functionally Important Respiratory Symptoms Among US Adolescents/Young Adults.

Poly (ADP-ribose) polymerase (PARP) inhibitors represent a promising new class of agents that have demonstrated efficacy in treating various cancers, particularly those that carry BRCA1/2 mutations. The cancer associated BRCA1/2 mutations disrupt DNA double strand break (DSB) repair by homologous recombination (HR). PARP inhibitors (PARPis) have been applied to trigger synthetic lethality in BRCA1/2-mutated cancer cells by promoting the accumulation of toxic DSBs. Unfortunately, resistance to PARPis is common and can occur through multiple mechanisms, including the restoration of HR and/or the stabilization of replication forks. To gain a better understanding of the mechanisms underlying PARPi resistance, we conducted an unbiased CRISPR-pooled genome-wide library screen to identify new genes whose deficiency confers resistance to the PARPi olaparib. Our study revealed that ZNF251, a transcription factor, is a novel gene whose haploinsufficiency confers PARPi resistance in multiple breast and ovarian cancer lines harboring BRCA1 mutations. Mechanistically, we discovered that ZNF251 haploinsufficiency leads to constitutive stimulation of DNA-PKcs-dependent non-homologous end joining (NHEJ) repair of DSBs and DNA-PKcs-mediated fork protection in BRCA1-mutated cancer cells (BRCA1mut + ZNF251KD). Moreover, we demonstrated that DNA-PKcs inhibitors can restore PARPi sensitivity in BRCA1mut + ZNF251KD cells ex vivo and in vivo. Our findings provide important insights into the mechanisms underlying PARPi resistance and highlight the unexpected role of DNA-PKcs in this phenomenon.
University of Pennsylavania School of Medecine.
Temple University Lewis Katz School of Medicine.
Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells.

Novel fluorescent probes were constructed for the convenient and rapid analysis of Cu2+ ions, taking advantages of the the triphenylamine backbone as chromophore and acylhydrazone group as the Cu2+ recognition site. Especially, probe T2 could act as a dual-channel probe towards Cu2+ through both fluorescent and colorimetric method. Through the fluorescent method, the detection limit of probe T2 was calculated to be as low as 90 nmol/L and there was a good linear relationship between the intensity change and the concentration of Cu2+ ions. By virtue of the two-phase liquid-liquid extraction method, probe T2 could be successfully applied in practical extraction and separation of Cu2+. Furthermore, by applying a turn-off-turn-on circle, compound T2 could act as a sensitive probe towards S2- anions through the indirect approach and the detection limit of complex T2-Cu2+ for S2- anion was found to be 110 nmol/L.
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, 441053, China. chengxiaohong0807@126.com.
School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, 441053, China.
Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, 441053, China.
Acylhydrazone Functionalized Triphenylamine-Based Fluorescent Probe for Cu2+: Tunable Structures of Conjugated Bridge and Its Practical Application.

Fe3O4@Y2O3:Eu3+ nanocomposites and Y2O3:Eu3+ nanophosphors were synthesized using the hydrothermal method. Nanocomposites were analyzed using X-ray diffraction (XRD), Rietveld refinements, Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, photoluminescence (PL), vibrating sample magnetometer (VSM), and high-resolution transmission electron microscopy (HRTEM). Nanocomposites exhibit superparamagnetic behavior that improves with Eu3+, resulting in increased magnetic saturation. In contrast to Y2O3:Eu3+ nanophosphors, the Fe3O4@Y2O3:Eu3+ nanocomposites display a distinctive characteristic whereby the photoluminescence intensity increases with a reduced concentration of Eu3+. The requirement of increasing the thickness of the Y2O3:Eu3+ outer layer to achieve improved light emission can be circumvented by solely manipulating the concentration of activators, without compromising the magnetic saturation of the nanocomposites. The luminescent and magnetic characteristics of Fe3O4@Y2O3:Eu3+ nanocomposites can be readily optimized using straightforward synthesis parameters, making them promising candidates for potential applications in theranostic medicine.
Centro Universitario de los Valles, Universidad de Guadalajara, Jalisco, 46600, México.
Centro Universitario de la Ciénega, Universidad de Guadalajara, Jalisco, 47820, México.
Microscopia de Alta Resolución, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, 78210, México.
Centro Universitario de los Valles, Universidad de Guadalajara, Jalisco, 46600, México. celso.velasquez@valles.udg.mx.
Improvement of Magnetic Saturation in Fe3O4@Y2O3:Eu3+ Nanocomposites Through the Manipulation of Eu3+ Activators.

In this study, salicylaldehyde (SA) conjugated gold nanoclusters were synthesized, characterized, and applied for the fluorescent turn-on sensing of Cd2+. The trypsin-stabilized fluorescent gold nanocluster (Tryp-AuNCs, λem = 680 nm) was modified with SA to form the spherical-shaped SA_Tryp-AuNCs. After modification, the red-emitting Tryp-AuNCs turned to green-emitting SA_Tryp-AuNCs because of the formation of imine linkage between the -CHO group of SA with the -NH2 group of functionalized trypsin. The modified SA_Tryp-AuNCs selectively interacted with Cd2+ and exhibited a fluorescence enhancement at 660 nm. The Cd2+ detection with SA_Tryp-AuNCs is simple and rapid with an estimated nanomolar detection limit of 98.1 nM. The practical utility of SA_Tryp-AuNCs was validated by quantifying Cd2+ in real environmental water samples.
Department of Chemistry, Sardar Vallabhbhai National Institute Technology, 395007, Surat, Gujarat, India.
Department of Chemistry, Sardar Vallabhbhai National Institute Technology, 395007, Surat, Gujarat, India. sks@chem.svnit.ac.in.
Fluorescent Switch-on Detection of Cadmium(II) Using Salicylaldehyde-Decorated Gold Nanoclusters.

This research presents the application of Dinaphthoylated Oxacalix[4]arene (DNOC) as a novel fluorescent receptor for the purpose of selectively detecting nitroaromatic compounds (NACs). The characterization of DNOC was conducted through the utilization of spectroscopic methods, including 1H-NMR, 13C-NMR, and ESI-MS. The receptor demonstrated significant selectivity in acetonitrile towards several nitroaromatic analytes, such as MNA, 2,4-DNT, 2,3-DNT, 1,3-DNB, 2,6-DNT, and 4-NT. This selectivity was validated by the measurement of emission spectra. The present study focuses on the examination of binding constants, employing Stern-Volmer analysis, as well as the determination of the lowest detection limit (3σ/Slope) and fluorescence quenching. These investigations aim to provide insights into the inclusion behavior of DNOC with each of the six analytes under fluorescence spectra investigation. Furthermore, the selectivity trend of the ligand DNOC for NAC detection is elucidated using Density Functional Theory (DFT) calculations conducted using the Gaussian 09 software. The examination of energy gaps existing between molecular orbitals, namely the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), provides a valuable understanding of electron-transfer processes and electronic interactions. Smaller energy gaps are indicative of heightened selectivity resulting from favorable electron-transfer processes, whereas bigger gaps suggest less selectivity attributable to weaker electronic contacts. This work integrates experimental and computational methodologies to provide a full understanding of the selective binding behavior of DNOC. As a result, DNOC emerges as a viable chemical sensor for detecting nitroaromatic explosives.
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India.
Department of Chemistry, Silver Oak Institute of Science, Silver Oak University, Ahmedabad, Gujarat, India. panchal_manthan@ymail.com.
Department of Chemistry, Faculty of Science, Ganpat University, Kherva, 384012, Mehsana, Gujarat, India.
Department of Humanities and Science, School of Engineering, Indrashil University, Mehsana, 382740, Gujarat, India. kmodi5033@gmail.com.
Chemical Engineering Department, Institute of Technology, Nirma University, Ahmedabad, 382481, Gujarat, India.
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, Gujarat, India. drvkjain@hotmail.com.
Fluorescence Quenching and the Chamber of Nitroaromatics: A Dinaphthoylated Oxacalix[4]arene's (DNOC) Adventure Captured through Computational and Experimental Study.

This study aimed to compare the effectiveness of high-intensity progressive rehabilitation training with routine training in the early treatment of patients undergoing total knee arthroplasty.There were 78 patients who underwent total knee arthroplasty and were randomized into high-intensity progressive training and routine rehabilitation training groups (RRT). The primary outcome measures were the American Hospital for Special Surgery Knee Score (HSS), with secondary outcomes including patient satisfaction, visual analog pain score, first time of standing after surgery, 6-minute walk test, 36-Item Short Form Survey (SF-36), and length of hospital stay. The incidence of postoperative complications were recorded.The HSS scores were higher in the intervention group at 2 weeks, 3 months, and 12 months postoperatively (P < .001). The RRT group had higher visual analog pain scores than the intervention group at 24 hours, 3 days, and 2 weeks after surgery (P < .001). The intervention group had an earlier the first time of standing after surgery and a longer 6-minute walk test distance (P < .001, P = .028, P < .001, P < .001). Patient satisfaction was higher in the intervention group, with a higher quality of life rating at 3 months postoperatively (P < .001). However, 1 year after surgery, the 2 groups had no significant differences in mental component summaries. The length of hospital stay was shorter in the intervention group than in the RRT group.Compared to routine training, high-intensity progressive rehabilitation training is more effective. It reduces postoperative patient pain, accelerates recovery of joint function, increases patient satisfaction, improves quality of life, shortens hospital stays, and promotes rapid recovery.
Copyright © 2023 Elsevier Inc. All rights reserved.
Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China.
Department of Traumatic Orthopaedics, The Central Hospital of Xiaogan, Hubei, China.
Department of Orthopedics, Foshan Fosun Chancheng Hospital, Foshan, China.
High-Intensity Progressive Rehabilitation Versus Routine Rehabilitation After Total Knee Arthroplasty: A Randomized Controlled Trial.

Hypochlorite (ClO-), a crucial chemical in the living organism, engages in various physiological activities. However, high amounts of ClO- result in oxidative damage. In this work, a commercially available 2-aminoanthracene (AA) was used to detect ClO-. AA demonstrated distinct properties such as superior selectivity and rapid response (< 30 s) with a low detection limit (140 nM) towards ClO- in 100% buffer solution. Furthermore, the probe exhibited a notable achievement by effectively identifying the presence of ClO- in complicated water samples. In conclusion, AA offers an easy-to-use and accurate method for quantifying ClO- in complex water samples.
Organic Chemistry Laboratory, Chemistry Group, National Metrology Institute, (TUBITAK UME), Gebze, Kocaeli, 41470, Turkey. garensuna@gmail.com.
A Commercially Available 2-aminoanthracene Fluorescent Probe for Rapid and Sensitive Detection of Hypochlorite in 100% Buffer Solution and its Application in Complex Water Samples.

Diabetic foot ulcers (DFUs) are one of the most common and challenging complications of diabetes, yet our understanding of their pathogenesis remains limited. We collected gene expression data of DFU patients from public databases. Bioinformatics tools were applied for systematic analysis, including the identification of differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA) and enrichment analysis. We further used single-cell RNA sequencing to identify the distribution of different cell populations in DFU. Finally, key results were validated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and flow cytometry. We identified 217 DEGs between ulcerated and healthy skin, and 37 DEGs between healing ulcers and ulcers. WGCNA revealed that the cyan module had the highest positive correlation with healthy skin and negative correlation with ulcers. The black module had the highest negative correlation with healthy skin and positive correlation with ulcers. Enrichment analysis showed that the genes in the cyan module were mainly associated with complement and coagulation cascades, while the genes in the black module were mainly associated with the IL-17 signalling pathway. In addition, CD8 T cells were significantly lower in ulcers than in healthy and healing ulcers. By comparing marker genes of CD8 T cells, we identified key genes in the cyan and black modules and validated their expression using RT-qPCR. The proportion of CD8 T cells was increased in healing ulcers. Flow cytometry detected increased levels of CD8 T, B and natural killer cells in healing ulcers. CD8 T cells and related key genes play an important role in the healing process of DFU. The results of this study provide a new perspective for understanding the pathogenesis and treatment of DFU.
© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
Department of Burns, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
Identification of potential immunologic resilience in the healing process of diabetic foot ulcers.

Multi-targets detection has obtained much attention because this sensing mode can realize the detection of multi-targets simultaneously, which is helpful for biomedical analysis. Carbon nanoparticles have attracted extensive attention due to their superior optical and chemical properties, but there are few reports about red emission carbon nanoparticles for simultaneous detection of multi-targets. In this paper, a red emission fluorescent carbon nanoparticles were prepared by 1, 2, 4-triaminobenzene dihydrochloride at room temperature. The as-prepared red emission fluorescent carbon nanoparticles exhibited strong emission peak located at 635 nm with an absolute quantum yield up to 24%. They showed excellent solubility, high photostability and good biocompatibility. Furthermore, it could sensitively and selectively response to hypochlorite and pH, thus simultaneous detection of hypochlorite and pH was achieved by combining the red emission fluorescent carbon nanoparticles with computational chemistry. The formation mechanisms of red emission fluorescent carbon nanoparticles and their response to hypochlorite and pH were investigated, respectively.
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
School of Life Sciences, University of Science and Technology of China, Hefei, 230027, People's Republic of China.
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China. qishd@lzu.edu.cn.
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China. rencl@lzu.edu.cn.
Red Emission Carbon Nanoparticles Which Can Simultaneously Responding to Hypochlorite and pH.

In this work, we synthesized cryptate copper(II) followed by complexed with sulfonate chitosan (SCS). After characterization, the evaluation of the antioxidant properties of resulting complexes were carried out by 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH•), hydroxyl radical (•OH), and 2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS•+), while the antibacterial and biofilm inhibitory activity against Pseudomonas aeruginosa PAO1 (P. aeruginosa PAO1) were also investigated. According to the results, cryptate copper(II) exhibited the best antioxidant activity followed by cryptate copper(II)/SCS complexes, and SCS. Significant antibacterial activity of cryptate copper(II) against P. aeruginosa PAO1 was observed with the minimum inhibitory concentration of MIC value 12.50 μg/mL and minimum bactericidal concentration of MBC value 100.00 μg/mL, followed by cryptate copper(II)/SCS complexes and SCS. Cryptate copper(II) and cryptate copper(II)/SCS exhibited antibacterial activity which copper ions might enter the interior of cells, and the intracellular ions made the killed bacteria serve as an antibacterial agent showing a zombie effect. The copper ions complexed with cryptate and SCS rendering potential unlimited biological activities, might become one of the most popular research areas because of their unique coordination chemistry and their long-term biological activities.
Copyright © 2023 Elsevier B.V. All rights reserved.
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, PR China.
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310018, PR China. Electronic address: huangjy@zjgsu.edu.cn.
International journal of biological macromolecules
Preparation, antioxidant and antibacterial activities of cryptate copper(II)/sulfonate chitosan complexes.

Here, we developed a novel isoniazid based fluorescent probe (E)-N'-(thiophen-2-ylmethylene)isonicotinohydrazide (TINH) through simple condensation reaction and employed for selective detection of Pd2+ ions with a low detection limit of 4.102 × 10-11 M. Among the many existing cations, TINH bound Pd2+ ions with an association affinity of 9.794 × 105 M-1. Adding Pd2+ ions to ligand solution increased the absorption intensity in UV-Visible and quenched the emission intensity in fluorescence spectroscopic experiments. More importantly, this TINH complexed to Pd2+ ions in 1:1 stoichiometric ratio. To evaluate the stability of complexed system, pH experiments has been performed. The binding insights among the ligand and Pd2+ ions has been confirmed by IR spectroscopic and MASS spectrometric methods. Additionally, TINH also applied to real water samples for the identification and measurement of Pd2+ ions. Hence, this system could be highly applicable for detection of Pd2+ ions in environmental and industrial samples with in low detection range.
Department of Chemistry, Baba Mastnath University, Rohtak, 124021, India.
Bharat Institute of Pharmacy Degree Course, Pehladpur, Babain-Kurukshetra, 136132, India.
Department of Chemistry, Indira Gandhi National College, Ladwa, Kurukshetra, 136132, India. ravishynr@gmail.com.
Department of Chemistry, Baba Mastnath University, Rohtak, 124021, India. pallavibhardwaj@bmu.ac.in.
Department of Chemistry, Kurukshetra University Kurukshetra, Kurukshetra, 136119, India.
Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonepat, 131039, Haryana, India.
An Isoniazid Based Schiff Base Sensor for Selective Detection of Pd2+ Ions.

A novel reaction-based fluorescent probe 1 for Hg2+ was designed and synthesized. 1 was almost nonfluoresent due to inhibition of the ESIPT process between hydroxy group and imid carbonyl oxygen by diphenylphosphinothioate group. After reacting with Hg2+, the fluorescence intensity of 1 exhibited significant enhancement owing to recovery of the ESIPT process via Hg2+-promoted desulfurization-hydrolysis of the diphenylphosphinothioate moiety and cleavage of the P-O bond. 1 not only showed rapid response, high sensitivity, excellent selectivity for Hg2+ over other metal ions, but also could detect Hg2+ with large Stokes shift (165 nm), which was attributed to the ESIPT process. Moreover, the reaction mechanism was fully validated by absorption spectra, fluorescence spectra, fluorescence color as well as ESI-MS analysis.
Guangxi Key Laboratory of Health Care Food Science and Technology, College of Food and Bioengineering, Hezhou University, Hezhou, 542899, People's Republic of China.
Guangxi Key Laboratory of Health Care Food Science and Technology, College of Food and Bioengineering, Hezhou University, Hezhou, 542899, People's Republic of China.College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, People's Republic of China.
Guangxi Key Laboratory of Health Care Food Science and Technology, College of Food and Bioengineering, Hezhou University, Hezhou, 542899, People's Republic of China. rash_yudi@163.com.
A Reaction-Based ESIPT Fluorescent Probe for the Detection of Hg2+ with Large Stokes Shift.

Organic dyes have shown a remarkable nonlinear optical (NLO) characteristics under low power laser regime because of chemical stability, large nonlinearity and high susceptibility. With this view in mind, herein we report the third-order NLO features of lissamine green dye using 5 mW power laser with operating wavelength of 650 nm. The lissamine green dye is dissolved into various polar solvents such as ethanol, methanol, acetone and DMSO. The closed aperture Z‒scan approach discloses the information about nonlinear refractive index, whereas the open aperture Z‒scan technique provides the information about nonlinear absorption coefficient. The closed aperture curve shows the peak-valley transmittance is the result of self-defocusing nonlinearity and the open aperture transmittance curve switchover from saturable absorption to reverse absorption in high polar solvent due to polarizability and dipole moment. The third-order NLO features such as nonlinear refractive index (n2), nonlinear absorption coefficient (β), real and imaginary features of third-order NLO susceptibility of the dye is calculated to be the order of, 10-7 cm2/W 10-3 cm/W, and 10-7 esu respectively. The correlation between solvent polarizability and dipole moment on lissamine green dye is discussed. The results are revealed that the lissamine green dye is a good candidate for NLO applications.
Department of Physics, Sri Sairam Engineering College, West Tambaram, Chennai, 600044, Tamilnadu, India.
Department of Physics, Veltech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai, 600062, Tamilnadu, India.
Department of Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, Tamilnadu, India.
Department of Physics, Takshashila University), Ongur, Tindivanam, Villupuram, 604305, PO, Tamilnadu, India. jeyaram.msc@gmail.com.
Saturable and Reverse Saturable Absorption Features of Lissamine Green Dye in Different Solvent Media.

A series of new red luminescent Eu(III) complexes were integrated by β-hydroxyketone ligand 2-(4-chlorophenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)ethan-1-one (CHDME) as main ligand and 1,10-phenanthroline (phen) or 5,6-dimethyl-1,10-phenanthroline (dmphen) or bathophenanthroline (bathophen) as ancillary ligand. The complexes were synthesised by solution precipitation method. The CHDME is taken as ligand and its analogous Eu(III) complexes were characterized by elemental analysis, FT-IR and 1H-NMR. The photoluminescent properties were also examined in solid state. The Judd-Ofelt intensity parameters (Ω2 and Ω4) and luminescence quantum efficiency (η) of Eu(III) complexes were additionally figured out as per luminescence spectra and decay cure. UV analysis and optical band was also calculated. Computational analysis were carried out and optical band and Judd-Ofelt intensity parameters were determined. Furthermore, the pharmacological activities such as antimicrobial and antioxidant activity of ligand CHDME and its analogous Europium complexes were also examined. The methods used were tube dilution method for calculating antimicrobial activity and DPPH free radical method for antioxidant activity.
University Institute of Engineering and Technology, Maharshi Dayanand University, Rohtak, , 124001, India.
Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttarakhand, 248001, India.
Deenbandhu Chhotu Ram University of Science and Technlogy, Murthal, 131039, India.
Department of Chemistry, Maharshi Dayanand University, Rohtak, 124001, India.
University Institute of Engineering and Technology, Maharshi Dayanand University, Rohtak, , 124001, India. lather_rajesh@yahoo.com.
New Highly Luminescent Red Emitting Complexes: Synthesis, Characterization, Judd-Ofelt Intensity Parameters and Pharmacological Investigations.

In this work, Y2O3: Tm3+, Eu3+ phosphors were made by homogeneous precipitation with urea as precipitator. The emission spectra varying with temperature of Y2O3: Tm3+, Eu3+ phosphors were measured and analyzed. Analysis show that the luminescence of Eu3+ represents a normal thermal quenching change, while that of Tm3+ exhibits slow thermal enhancement phenomenon. In the temperature range of 303-503 K, the luminescence of Tm3+ showed a trend of first strengthening and then weakening. The reason for this phenomenon of Tm3+ is that there is energy transfer from Eu3+ to Tm3+, and the energy transfer efficiency increases gradually with temperature. Meanwhile, the luminescence of Tm3+ also have thermal quenching effect. Under the combined influence of thermal quenching and energy transfer, the luminescence of Tm3+ first becomes stronger and then then becomes weaker. According to the calculation, the luminescence intensity ratio (LIR) of Tm3+ and Eu3+ conforms to the linear empirical formula with increasing temperature. The relative sensitivity of phosphors decreases with Eu3+ concentration increased, and the maximum Sr reaches 0.460% K-1 (1% Tm3+, 0.3% Eu3+, at 303 K). Moreover, the temperature cycle test present that the LIR of phosphors has good repeatability.
Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin, 150025, People's Republic of China.
Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin, 150025, People's Republic of China. mengqingyu@hrbnu.edu.cn.
Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin, 150025, People's Republic of China.Suihua University, Suihua, 152000, People's Republic of China.
Optical Temperature Sensing Based on Linear Change of Luminescence Intensity Ratio in Y2O3: Tm3+, Eu3+ Phosphors.

In this study, we have synthesized a novel Schiff base-centered chemosensor, designated as SB, with the chemical name ((E)-1-(((6-methylbenzo[d]thiazol-2-yl) imino)methyl)naphthalen-2-ol). This chemosensor was structurally characterized by FT-IR, 1H NMR, UV-Vis and fluorescence spectroscopy. After structural characterization the chemosensor SB was subsequently employed for the detection of Cu2+ and Ag+, using fluorescence spectroscopy. The chemosensor SB showed excellent ability to recognize the target metal ions, leading to fluorescence enhancement and color change from yellow to yellowish orange for Cu2+ and yellow to radish for Ag+ ions. The detection capabilities of this chemosensor were impressive, showing excellent selectivity and an exceptionally low detection limit of 0.0016 µM for Cu2+ and 0.00389 µM for Ag+. Most notably, our approach enables the quantitative detection both metal ions in different water and soil samples at trace level. This achievement holds great promise for analytical applications and offers significant contributions to the field of chemical sensing and environmental protection.
Department of Biology, College of Science, Jazan University, P.O. Box 2079, Jazan, 45142, Saudi Arabia.
Department of Chemistry, University College in Al-Jamoum, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.
Department of Chemistry, Faculty of Science, Umm Al-Qura University, 24230, Makkah, Saudi Arabia.
Department of Chemistry, College of Science and Arts, Najran University, P.O. Box, 1988, 11001, Najran, Saudi Arabia.
Department of Chemistry, College of Science and Arts, Najran University, P.O. Box, 1988, 11001, Najran, Saudi Arabia. Jsalgethami@nu.edu.sa.Advanced Materials and Nano-Research Centre (AMNRC), Najran University, 11001, Najran, Saudi Arabia. Jsalgethami@nu.edu.sa.
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Colorimetric Detection of Cu2+ and Ag+ Ions Using Multi-Responsive Schiff Base Chemosensor: A Versatile Approach for Environmental Monitoring.

Novel quinoline derivatives were synthesized based on 6-amino-substituted quinoline, and antioxidant activity of these compounds is studied by p-nitroso-N,N-dimethylaniline assay. The rate of the reaction between OH radicals and quinoline derivatives is determined by photometric method and the obtained results are compared with that of well-known antioxidant vitamin C. Quinoline derivatives exhibit pronounced antioxidant activity, which strongly depends on the structural features of compounds. Photophysical properties such as UV-Vis absorption and fluorescence maxima, and Stokes shift are also reported. To reveal the potential application of novel quinoline derivatives as fluorescence probes the values of quantum yields are determined and the obtained results are explained in terms of structural features of compounds.
Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Yerevan State University, Yerevan, 0025, Armenia. armart@ysu.am.Department of Organic Chemistry, Faculty of Chemistry, Yerevan State University, Yerevan, 0025, Armenia. armart@ysu.am.
Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Yerevan State University, Yerevan, 0025, Armenia.
Department of Organic Chemistry, Faculty of Chemistry, Yerevan State University, Yerevan, 0025, Armenia.
Synthesis, Photophysical Properties and Antioxidant Activity of Novel Quinoline Derivatives.

This study examined the surface morphology and photocatalytic activity of nickel oxide (NiO) nanoparticles prepared through a chemical method. The synthesized nanoparticle was characterized by using spectroscopic and microscopic techniques. Photocatalytic degradation of hazardous Eriochrome Black T (EBT) was carried out using the synthesized nanoparticle and the efficiency of the NiO used was determined. Highest degradation efficiency of 70% at 25 mg loading was observed at 40 min exposure time. The study concluded that the synthesized nanoparticles could be used in industrial wastewater treatment containing organic dyes.
Department of Chemistry, Obafemi Awolowo University, Ile-Ife, PMB, 220005, Nigeria. sadekpreto@gmail.com.
Department of Chemistry, Obafemi Awolowo University, Ile-Ife, PMB, 220005, Nigeria.
Department of Chemistry, Obafemi Awolowo University, Ile-Ife, PMB, 220005, Nigeria. solomonsun77@gmail.com.
Department of Chemical Sciences, University of Johannesburg Doornfontein, Johannesburg, 2028, South Africa. oluwatobi.oluwafemi@gmail.com.Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa. oluwatobi.oluwafemi@gmail.com.
Photocatalytic Degradation of Dyes in Wastewater Using Solar Enhanced Nickel Oxide (NiO) Nanocatalysts Prepared by Chemical Methods.

Waste peels are considered an environmental burden and typically disposed in landfills. The aim of this study was to investigate the effects of various solvents on the luminescence properties of carbon quantum dots (CQDs). Watermelon peels were recycled and reuse as precursors for the synthesis of biomass CQDs via a green carbonization method. The colloidal stability, surface charge, and particle size were characterized using zeta potential and dynamic light scattering (DLS). DLS revealed that the size of the CQDs was approximately 5.80 ± 0.4 nm to 9.74 ± 0.8 nm. The high-resolution transmission electron microscopy (HRTEM) results demonstrated a correlation with the DLS results. The optical properties were characterized by photoluminescence (PL) and UV-Visible (UV-Vis) spectroscopy. PL measurements at different excitation wavelengths revealed that the CQDs emissions were influenced by the polarity of the solvents. Meanwhile, the Fourier transform infra-red (FTIR) results showed the presence of oxygen-containing groups on the surface of the CQDs. These results deepen our understanding of the solvent-dependent behavior and colloidal stability of the CQDs.
Department of Physics, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Seri Kembangan, 43400, Malaysia.
Department of Physics, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Seri Kembangan, 43400, Malaysia.Institute of Nanoscience and Nanotechnology, Universiti Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Seri Kembangan, 43400, Malaysia.
Department of Physics, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Seri Kembangan, 43400, Malaysia. mazliana_ak@upm.edu.my.
Solvent-Dependent Photoluminescence Emission and Colloidal Stability of Carbon Quantum dots from Watermelon Peels.

The (0.90)Y2O3:(0.10-x)Eu3+:(x)Bi3+ nanophosphors (0.00 ≤ x ≤ 0.06) are synthesised using chemical combustion citrate route and characterized via X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, UV- visible and photoluminescence spectroscopy. The scanning electron micrographs indicate that the grain size of the phosphors ranges between 40 to 50 nm. The photoluminescence (PL) spectra, acquired under the excitation wavelength of 365 nm of ultraviolet light, show emission peaks at wavelengths 580 nm, 586-598 nm, 610 nm, 629-661 nm and 686-695 nm corresponding to the 5D0 → 7FJ electronic transitions of the Eu3+ ion with J = 0, 1, 2, 3 and 4, respectively. The most intense PL spectra at 611 nm (5D0 → 7F2), showcasing reddish-orange emission, indicate a higher concentration of Eu3+ ions in asymmetric sites within the Y2O3 host matrix. The presence of the distinct electronic transitions of Eu3+ in PL spectra acclaims that Bi3+ ions transfer their energy efficiently to Eu3+ ions in the matrix. Physical and chemical tests are being conducted on nanophosphors with Bi3+ substitutional doping of x = 0.02 and x = 0.04, both demonstrating intense PL emission. Magnetisation measurements suggest the soft magnetic nature of the nanophosphors, attributing it to the presence of Eu3+ ions in the 7F2 state. The highest PL intensity is seen in the nanophosphor (x = 0.04) with substitutional doping of 6% of Eu3+ and 4% of Bi3+ in Y2O3. This nanophosphor also demonstrates excellent optical stability in the investigated conditions and exhibits soft magnetic behaviour, positioning it as a promising material for incorporation as a fluorescent magnetic pigment in security ink applications. These features serve to prevent counterfeiting of secured documents both optically and magnetically.
Department of Chemistry, Faculty of Mathematical and Physical Sciences, M S Ramaiah University of Applied Sciences, Bengaluru, 560058, India.
Department of Physics, Faculty of Mathematical and Physical Sciences, M S Ramaiah University of Applied Sciences, Bengaluru, 560058, India. premhb@gmail.com.
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, 23285, USA.
Department of Physics, Indian Institute of Technology-Patna, Patna, Bihar, 801106, India.
Department of Physics, Maharaja Institute of Technology Mysore (Affiliated to Visvesvaraya Technological University, Belagavi), Mandya, 571477, Karnataka, India. drvldayal@gmail.com.
Department of Chemistry, Faculty of Mathematical and Physical Sciences, M S Ramaiah University of Applied Sciences, Bengaluru, 560058, India. niranjan1975@gmail.com.
Exploring Optically Stable Reddish-Orange Fluorescent Magnetic Pigment (0.90)Y2O3:(0.10-x)Eu3+:(x)Bi3+ for Anti-counterfeiting Applications.

Solvent environment on third-order nonlinear optical (TNLO) features of triarylmethane dye namely, basic blue 7 in different solvents is reported herein using 650 nm diode laser with continuous wave mode. The basic blue 7 dye is dissolved in different solvent media including ethanol, methanol, dimethyl formamide (DMF) and dimethyl sulfoxide (DMSO). The influence of solvent characteristics such as solvent polarizability and dipole moment on solute molecule is discussed. TNLO characteristics such as nonlinear optical index of refraction, nonlinear optical coefficient of absorption, real and imaginary components of the TNLO susceptibility are measured to be the order of 10‒7 cm2/W, 10‒3 cm/W, 10‒6 esu and 10‒7 esu, respectively. The dye exhibits large TNLO susceptibility by dissolving in DMSO. The TNLO susceptibility of basic blue 7 dye is measured to be the order of 10‒6 esu. The overall results revealed that the basic blue 7 dye is suitable material for optoelectronics applications.
Department of Physics, Takshashila University, Ongur (PO), Tindivanam, Villupuram, 604305, Tamilnadu, India. jeyaram.msc@gmail.com.
Solvent Media on Nonlinear Optical Properties of Triarylmethane Dye via Facile Z-Scan Method.

Department of Stomatology, Yulin First Hospital, Yulin, Shaanxi, China.
Department of Stomatology, Tangshan Central Hospital, Tangshan, Hebei, China. zxue163zxue@163.com.
Department of Chemistry, Qingdao Medical University, Qingdao, Shandong, China.
Retraction Note: Two Transition Metal Coordination Polymers: Luminescent Sensing Properties and Treatment Effect on Chronic Periodontitis by Reducing IL-6 and TNF-α Content.

Fluoride is both necessary and potentially harmful in excessive amounts, making its detection crucial. Fluorescent probes provide a sensitive and selective means for this purpose. In this study, we developed and synthesized a fluorescent probe for LDT using phenothiazine derivatives and aryl vinyl nitrile. Initially non-fluorescent, the probe undergoes a Si-O bond breakage in the presence of fluoride ions, resulting in the formation of a larger conjugated system and subsequent fluorescence emission. The probe exhibits superior selectivity and sensitivity towards fluoride ions, with a detection limit of 0.35 µM. Moreover, cellular imaging experiments demonstrated the probe's effectiveness in recognizing fluoride ions within HepG2 cells.
School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.
School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China.Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, 550025, China.
School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China. lliu2@gzu.edu.cn.Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, 550025, China. lliu2@gzu.edu.cn.
Design, Synthesis, and Cellular Imaging Application of a Fluorescent Probe Based on Fluoride Ion-Induced Cyclization of Phenothiazine Derivatives.

The design and development of novel efficient fluorescent chemical sensors for the selective detection of ions is currently of significant importance in supramolecular chemistry. Since zinc is a ubiquitous, indispensable and the second most abundant metal ion in the human body, developing chemosensors that can accurately discriminate between Zn2+ and Cd2+ ions has been a challenge due to their similar properties as they are in the same group of the periodic table. Therefore, a technique to trace and visualize free zinc ions is demanded. In this study, an innovative coumarin-based Schiff base (L) was synthesized and characterized by 1H NMR, 13C NMR and mass spectroscopy. A novel Turn On fluorescence chemosensor platform was developed for trace amounts of Zn2+ ions. The fluorescence Job's plot measurement was used to determine the complexation ratio between the probe and Zn2+ ion, which showed a maximum point indicating the formation of a ML2 adduct. Additionally, the geometrical parameters calculated using DFT and TD-DFT calculations were in close agreement with the experimentally observed values.
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. hashemi325@gmail.com.
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Physical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, 47416-95447, Iran.
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. sdemami12@gmail.com.
Synthesis, Sensing Performance and DFT Studies of a Novel Coumarin-based Schiff Base As a Turn-on Fluorescence Probe for Zinc Ion Detection.

Silver nanoparticles (AgNPs) have been extensively utilized in various fields due to their excellent physical and chemical properties. The green synthetic routes for the synthesis of AgNPs have been adopted to eliminate the impact of the chemicals over the environment. These methods are more cost-effective, eco-friendly and simple. The association of AgNPs on to the surface of functionalized multi-walled carbon nanotubes (f-MWCNTs) produces nanocomposites with unique properties. This can be achieved by different methods such as covalent functionalization, non-covalent functionalization and so on. In the current study, AgNPs are synthesized by biochemical method and they are anchored on to the surface of functionalized MWCNTs is carried out via a non-covalent interaction. The fluorescence studies are done on the nanocomposites in the presence of a suitable external probe i.e., MB. Here fluorescence and UV-Visible spectroscopy are used.
Department of Chemistry, Ethiraj College For Women, Ethiraj Salai, Egmore, 600008, Chennai, Tamil Nadu, India. susithra.selvam@yahoo.com.
Department of Sciences, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, India.Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, India.
Department of Sciences, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, India. k_elango@cb.amrita.edu.Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, India. k_elango@cb.amrita.edu.
Evaluation of Multiwalled Carbon Nanotube-Silver Nanocomposite: A Fluorescence Spectroscopic Approach.

Cy5.5 and 7.5 are the most commonly used NIR 2-region fluoresceins, which have good luminescence properties and important biomedical tracer applications. In this paper, their molecular non-covalent interactions, UV-Vis absorption spectra, main bond lengths, electrostatic potential distributions, frontier molecular orbitals (HOMO and LUMO) and energy gaps were calculated by density functional theory (DFT). We found that the differences in the luminescence properties and energy gaps of Cy5.5 and Cy7.5 molecules may be caused by the length of the conjugated chains between the two aromatic rings in the molecule. By calculating the relevant molecular characteristics, this paper can provide ideas and theoretical basis for the relevant modification and application, as well as the development of new fluorescent dyes.
First Hospital of Lanzhou University, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, P. R. China.
Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, P. R. China.
First Hospital of Lanzhou University, Lanzhou University, 222 South Tianshui Road, Lanzhou, 730000, P. R. China. leijq2011@126.com.
Theoretical Study on Spectrum and Luminescence Mechanism of Cy5.5 and Cy7.5 Dye Based on Density Functional Theory (DFT).

In this paper, we report a D-A-D-A-type fluorescence sensor, FX, composed of triphenylamine and pyrazine units as electron donors, pyridine units, and α-β unsaturated carbon-based structures as electron acceptors. FX exhibits typical ICT characteristics. As a dual-emission material, FX undergoes acid-base-induced color changes and displays mechanofluorochromic properties in the solid state. In solution, FX, as an AIE material, shows significant fluorescence enhancement behavior in most halogenated solvents. Notably, it achieves a high quantum yield of 0.672 in a chloroform solution. We utilized this phenomenon to quantitatively detect chloroform through fluorescence titration analysis, with a detection limit of 0.061%. Additionally, we developed a test paper to verify the practical applicability of the sensor for detecting halogenated solvents. The fluorescence enhancement behavior was confirmed through DFT calculations. The results indicate that FX is not only a multifunctional dual-state emission material but also provides valuable references for the fluorescence detection of halogenated solvents.
College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637000, China.Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province of China, Nanchong, 637000, China.
College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637000, China. wangbin@cwnu.edu.cn.Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province of China, Nanchong, 637000, China. wangbin@cwnu.edu.cn.
Sichuan University of Science & Engineering, GongZi, 634002, China.
Lighting Up Fluorescence: Precise Recognition of Halogenated Solvents Through Effective Fluorescence Detection Using Chalcone Derivatives as a D-A-D-A-type Fluorescent Chemosensor.

For the efficient detection of Hg2+ and ClO-, a double-analyte-responsive fluorescent probe PTB was successfully synthesized by combining N-butyl-3-formyl phenothiazine with hydrazine benzothiazole, and designing a specific reaction site for recognizing two analytes (Hg2+ and ClO-) in a compound. It was shown that probe PTB successfully formed a stable complex with Hg2+ in the coordination ratio of 2:1 by using the strong sulfur affinity of Hg2+, which resulted in a remarkable turn-off effect, with a quenching efficiency of 92.5% and four reversible cycles of Hg2+ fluorescence detection. For the fluorescence detection of Hg2+, the response time is fast (≤ 2 min) and the detection limit is low (7.8 nM), showing extremely high sensitivity, and the performance is obviously better than that of the reported fluorescent probes for detecting Hg2+. In particular, probe PTB has low toxicity and good biocompatibility, and has been successfully used for imaging of Hg2+ in living cells. Moreover, probe PTB uses thioether bond and carbon-nitrogen double bond as reaction sites to detect ClO-, which has large Stokes Shift (149 nm), good selectivity, high quenching efficiency (96.5%) and fast time response (about 10 s), and successfully detects ClO- in actual water samples.
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China. zhangchenglu@lnnu.edu.cn.
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China.
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China. liuc@lnnu.edu.cn.
A Dual Functional Fluorescent Probe Based on Phenothiazine for Detecting Hg2+ and ClO- and its Applications.

Rare earth-doped nanophosphors have gained the attention of scientist as a result of their application in many devices like color display, laser cooling, bioimaging, and especially white light emitting diodes (WLEDs). Sr3La1-x(PO4)3: xDy3+ (x = 0.01 to 0.15 mol) white light emitting nanophosphors were synthesized by a resourceful and effective technique which is solution combustion synthesis utilizing urea as fuel at 1200 °C and their photoluminescence and structural properties were inspected using powder X-ray diffraction (PXRD) spectroscopy, energy dispersive X-ray (EDAX) spectroscopy, Transmission Electron Microscopy (TEM) and photoluminescence (PL) spectroscopy. Rietveld refinement employing on XRD data disclosed that synthesized samples are of cubic lattice with I-43d (220) space group. The photoluminescence emission spectra revealed two main characteristic bands at 480 nm and 574 nm, the band at 480 nm has magnetic-dipole transition characteristic to 4F9/2 → 6H15/2 responsible for blue light emission and the peak at 574 nm is for electric-dipole transition characteristic to 4F9/2 → 6H13/2 answerable for yellow light emission. x = 0.03 mol was found to be the optimum concentration for the nanophosphors series and the critical transfer distance (Rc) was determined to be 25 Å which eventually illustrated the existence of multipolar interactions between Dy3+ ions. CCT value (7908 K) and CIE coordinates (0.292, 0.320) of Sr3La0.97Dy0.03(PO4)3 nanophosphor confirmed their brilliant workability in the innovative optoelectronic devices, specifically single-phase WLEDs for the lighting purpose. So, this phosphor could be a potential component in near ultra-violet excited WLEDs.
Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Sonepat, 131039, India.
Department of Chemistry, A. I. Jat. H. M. College, Rohtak, 124001, India.
Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Sonepat, 131039, India. dineshdalal8@rediffmail.com.
Cool White-light Emanation Via Combustion Produced Sr3La(PO4)3: Dy3+ Single-phased Nanophosphors for Effective Lighting Devices.

Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal band (OCB) positivity, CSF band number and immunoglobulin G(IgG) index. The study aimed to evaluate whether the number of OCB can predict disease activity and determine a correlation with the IgG index.Our study included 401 MS patients who had relapsing-remitting multiple sclerosis (RRMS), primary progressive multiple sclerosis (PPMS), secondary progressive multiple sclerosis (SPMS), clinic isolated syndrome (CIS), radiologic isolated syndrome (RIS), Neuromyelitis optica spectrum disorder (NMOSD) and Acute disseminated encephalomyelitis (ADEM) with OCB number groups of 2-4, 4-8, 8-12, and 12 and above.No significant correlation was observed between IgG index, pre-and post-treatment EDSS (Expanded Disability Status Scale Scores) and disease-modifying therapies (DMT). Drug response was better in the patient group with band number between 2 and 8 and post-treatment EDSS scores were lower (1.62±0.44).The study results suggested that band number may be as valuable as the IgG index and a predictive biomarker for disease activity.
Copyright © 2023. Published by Elsevier B.V.
Antalya Training and Research Hospital Neurology Clinic, Turkey, Esra Taşkıran. Electronic address: es_ranil@hotmail.com.
Ondokuz Mayıs University Faculty of Medicine, Department of Neurology, Turkey, Murat Terzi.
Ondokuz Mayıs University Graduate School of Education, Department of Neurosciences, Turkey, Elif Merve Helvacı.
Ondokuz Mayıs University, Department of Biochemistry, Turkey, Meltem Zeycan ESER.
Ondokuz Mayıs University, Department of Biochemistry, Turkey, Bahaddin Avcı.
Uludag University Faculty of Medicine, Department of Neurology, Turkey, Ömer Faruk Turan.
Erciyes University Faculty of Medicine, Turkey, Mehmet Fatih Yetkin.
Van Yüzüncüyıl University Faculty of Medicine, Turkey, Vedat Çilingir.
Pamukkale University Faculty of Medicine, Turkey, Levent Sinan Bir.
Dokuz Eylul University Faculty of Medicine, Turkey, Sibel Canbaz Kabay.
Atatürk University Faculty of Medicine, Turkey, Nuray Bilge.
Private Medifema Hospital, Turkey, Turan Poyraz.
Firat University Faculty of Medicine, Turkey, Caner Feyzi Demir.
Sakarya University Faculty of Medicine, Turkey, Dilcan Kotan Dündar.
Muğla University Faculty of Medicine, Turkey, Ozgul Ocak.
Çanakkale University Faculty of Medicine, Turkey, Mustafa Çam.
Celal Bayar University Faculty of Medicine, Turkey, Hatice Mavioğlu.
Adıyaman University Faculty of Medicine, Turkey, Yaşar Altun.
Süleyman Demirel University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Turkey, Adnan Karaibrahimoğlu.
Multiple sclerosis and related disorders
The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis.

This review basically concerned with the application of different Schiff bases (SB) based fluorimetric (turn-off and turn-on) and colorimetric chemosensors for the detection of heavy metal cations particularly Al(III), Fe(III), and Cr(III) ions. Chemosensors based on Schiff bases have exhibited outstanding performance in the detection of different metal cations due to their facile and in-expensive synthesis, and their excellent coordination ability with almost all metal cations and stabilize them in different oxidation states. Moreover, Schiff bases have also been used as antifungal, anticancer, analgesic, anti-inflammatory, antibacterial, antiviral, antioxidant, and antimalarial etc. The Schiff base also can be used as an intermediate for the formation of various heterocyclic compounds. In this review, we have focused on the research work performed on the development of chemosensors (colorimetric and fluorometric) for rapid detection of trivalent metal cations particularly Al(III), Fe(III), and Cr(III) ions using Schiff base as a ligand during 2020-2022.
Chemistry Section, School of Sciences, Maulana Azad National Urdu University, Gachibowli, Hyderabad, 500032, India.
Chemistry Department, Directorate of Distance Education (DDE), Maulana Azad National Urdu University, Gachibowli, Hyderabad, 500032, India.
Department of Electrical and Electronics Engineering, Mewat Engineering College, Nuh Gurugram University Haryana, Gurugram, India. farazahmer007@gmail.com.
Recent Developments in Colorimetric and Fluorometric Detection Methods of Trivalent Metal Cations (Al3+, Fe3+ and Cr3+) Using Schiff Base Probes: At a Glance.

Archives of suicide research : official journal of the International Academy for Suicide Research

High-resolution global flood risk maps are increasingly used to inform disaster risk planning and response, particularly in lower income countries with limited data or capacity. However, current approaches do not adequately account for spatial variation in social vulnerability, which is a key determinant of variation in outcomes for exposed populations. Here we integrate annual average exceedance probability estimates from a high-resolution fluvial flood model with gridded population and poverty data to create a global vulnerability-adjusted risk index for flooding (VARI Flood) at 90-meter resolution. The index provides estimates of relative risk within or between countries and changes how we understand the geography of risk by identifying 'hotspots' characterised by high population density and high levels of social vulnerability. This approach, which emphasises risks to human well-being, could be used as a complement to traditional population or asset-centred approaches.
School of Geographical Sciences & Cabot Institute, University of Bristol, Bristol, UK. sean.fox@bristol.ac.uk.
Department of Planning, Property & Environmental Management, University of Manchester, Manchester, UK.
School of Geographical Sciences & Cabot Institute, University of Bristol, Bristol, UK.
School of Geographical Sciences & Cabot Institute, University of Bristol, Bristol, UK.Fathom, Bristol, UK.
Integrating social vulnerability into high-resolution global flood risk mapping.

Temporal bone paraganglioma (TBP) are the most common tumors of the middle ear. They pose a challenge in otologic surgery due to their extensive vascularity and intricate location within the middle ear. This meta-analysis aimed to compare the safety and efficacy of two surgical approaches, microscopic middle ear surgery (MMES) and endoscopic middle ear surgery (EMES), in the resection of TBP.Eligible studies published after 1988 were identified through systematic searches of PubMed , Scopus and Google Scholar . Retrospective studies and randomized/non-randomized control trials reporting on surgical approaches for TBP with a minimum of five adult patients were included.A total of 595 records were initially identified. After removing 229 duplicates, 349 articles were excluded based upon article subject, title and abstract. Following the review of full texts, 13 articles were assessed for eligibility. The pooled analysis included a total of 529 ears, with a complication rate of 7.8% for EMES and 14.2% for MMES. Subgroup differences indicated no significant variation between the two methods (p = 0.2945).Both EMES and MMES demonstrated favorable surgical outcomes with low complication rates for TBP resection. These findings suggest that EMES is a safe and effective method for TBP resection and one that is comparable to MMES. Since the risk of bleeding is significant in these tumors, a third-hand technique, endoscopic bipolar cautery or laser-assisted hemostasis should be considered. Conversion to MMES is another option when visibility is critically affected by bleeding.
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel.School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel.
Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel. ungaromer@gmail.com.School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel. ungaromer@gmail.com.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Success and safety of endoscopic versus microscopic resection of temporal bone paraganglioma: a meta-analysis.

Rhinitis medicomentosa (RM) is a form of non-allergic rhinitis caused by the use of nasal decongestants for longer than the recommended duration. Because of this problem of use, addiction to the drug occurs in individuals. In our study, we aimed to evaluate the susceptibility of RM patients to substance addiction.The study was planned as a prospective, multicentric study between September 2022 and September 2023. Patients diagnosed with RM were included in the study. Beck depression scale, Drug use disorders identification test, Substance Abuse Proclivity Scale were applied to the patients participating in the study. The research data were analyzed electronically with SPSS program version 25.The study included 86 patients with an average age of 31 years. The average duration of medication use was 22 months. Age, gender, duration of nasal congestion, duration of drug use and smoking were not independent predictors for depression and substance use tendency.The relationship between RM and addictive substances is not clear. The tendency to use drugs did not increase in RM patients. In the light of these data, we think that there is no need for a practice other than routine functioning in the use of drugs and similar substances that are likely to cause addiction in RM patients.
Faculty of Medicine, Department of Otorhinolaryngology, Recep Tayyip Erdogan University, Rize, Turkey. mehmet.birinci@erdogan.edu.tr.
Faculty of Medicine, Department of Otorhinolaryngology, Samsun University, Samsun, Turkey.
Faculty of Medicine, Department of Psychiatry, Recep Tayyip Erdogan University, Rize, Turkey.
Faculty of Medicine, Department of Otorhinolaryngology, Recep Tayyip Erdogan University, Rize, Turkey.
Rhinitis medicomentosa and substance addiction.

The aim of this study is to evaluate the efficacy of heated humidified high flow nasal cannula (HFNC) therapy as a conservative treatment option for newborns suffering from nasal stenosis, a condition that often leads to respiratory distress and feeding difficulties. Given the increasing utilization of HFNC in various upper and lower respiratory tract indications, characterized by its flow-based mechanism and minimal mucosal damage, we seek to investigate its potential benefits in this specific patient population.A retrospective chart review of newborns with congenital nasal stenosis treated with HFNC for respiratory distress or feeding difficulties in a pediatric tertiary center between 2014 and 2022. Data were collected for demographic characteristics, clinical presentation and ventilatory requirements, pre and post HFNC application.Six infants with nasal stenosis were included in the study cohort. Five were diagnosed with congenital pyriform aperture stenosis, three of whom had additional midnasal stenosis. One patient had nasal synechiae. Two patients had failed surgical treatment and all patients failed conservative treatment prior to HFNC treatment. Following HFNC use, improvement was noted in oxygen saturations, heart and respiratory rates, meal volumes and weight. None of the patients required any additional sinonasal surgical treatment. No complications were observed.In this case series, we present the first documented use of HFNC treatment for nasal stenosis, showing favorable results. Further studies with a larger cohort, wider range of conditions and extended follow-up periods are needed to establish the risks and benefits of HFNC for neonatal nasal stenosis.
Department of Otolaryngology - Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel. shany.havazelet@gmail.com.Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. shany.havazelet@gmail.com.
Institute of Pediatric Pulmonology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Institute of Pediatric Pulmonology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Department of Otolaryngology - Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Pediatric Otolaryngology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.Department of Pediatrics, Edith Wolfson Medical Center, Holon, Israel.
Heated humidified high-flow nasal cannula: a new conservative approach for neonatal nasal stenosis.

The Video Head Impulse Test (vHIT) is a safe and reliable assessment of peripheral vestibular function. Many studies tested its accuracy in clinical settings for differential diagnosis and quantification of the vestibulo-oculomotor reflex (VOR) in various disorders. However, the results of its application after lesions of the CNS are discordant and have never been studied in rehabilitation. This study aims to assess the VOR performance in a sample of stroke survivors.This is a cross-sectional study on 36 subacute and chronic stroke survivors; only persons with first-ever stroke and able to walk independently, even with supervision, were included. We performed VOR assessments for each semicircular canal by vHIT and balance assessments by the Berg Balance Scale and the MiniBESTest scale.Two hundred and sixteen semicircular canals were assessed using the Head Impulse paradigm (in both the vertical and horizontal planes), while 72 semicircular canals were assessed using the Suppressed Head Impulse paradigm (horizontal plane). There was a high prevalence of participants with dysfunctional canals, particularly for the left anterior and right posterior canals, which were each prevalent in more than one-third of our sample. Furthermore, 16 persons showed an isolated canal dysfunction. The mean VOR gain for the vertical canals had confidence intervals out of the normal values (0.74-0.91 right anterior; 0.74-0.82 right posterior; 0.73-0.87 left anterior).Our findings suggest that peripheral vestibular function may be impaired in people with stroke; a systematic assessment in a rehabilitation setting could allow a more personalized and patient-centred approach.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.Unit of Occupational Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138, Bologna, Italy.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy.Department of Movement, Human and Health Sciences, University of Rome Foro Italico , Rome, Italy.
Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy.
MSA ENT Academy Center, 03043, Cassino, Italy. lmanzari1962@gmail.com.
Video head impulse test in subacute and chronic stroke survivors: new perspectives for implementation of assessment in rehabilitation.

This study aimed to explore the diagnostic sensitivity of 3D heavily weighted T2-weighted MRI (T2MRI) and high-resolution computed tomography (HRCT) in patients with cochlear fibrosis associated with Streptococcus suis (S. suis) meningitis and the practicality of Cochlear implantation (CI) treatments.Between January 2020 and December 2022, we enrolled four patients with rare cochlear S. suis meningitis with associated hearing loss despite aggressive or non-aggressive follow-up antibiotic treatment. Clinical imaging data, surgical performances and post-surgical-electrode impedance were evaluated.Combined with HRCT and T2MRI, the cochlea had varying degrees of fibrosis and ossification in different cases. However, the electrodes were successfully and wholly inserted after intraoperative removal of the ossified and fibrotic foci. Post-surgical electrode impedance values of MP1 + 2 mode were normal in all 4 cases at initial activation.In patients with S. suis meningitis and associated cochlear fibrosis, T2MRI examination of the inner ear was more sensitive than HRCT. This research highlights the feasibility of CI treatment in S. suis meningitis patients with severe cochlear fibrosis.
Department of Otolaryngology Head & Neck Surgery, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle Road, Guangzhou, 510282, China.Ear Institude of Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Department of Otolaryngology Head & Neck Surgery, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle Road, Guangzhou, 510282, China. zhang_hongzheng@yeah.net.Ear Institude of Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. zhang_hongzheng@yeah.net.
Cochlear implantation for rare Streptococcus suis meningitis with hearing loss.

Sinonasal mucosal melanoma (SNMM) is a rare malignancy, characterised by high (local) recurrence rates and poor survival. Comprehensive understanding of tumour etiology is currently lacking, which complicates adequate tumour treatment. Besides examining trends in incidence, this study aims to assess the association between clinical characteristics, treatment practices and patient outcomes, with the objective of establishing a baseline from which SNMM management can be enhanced.All newly diagnosed SNMM cases in The Netherlands between 2001 and 2021 were included using data from The Netherlands Cancer Registry (NCR).A total of 320 patients were included. The annual incidence rate for the overall population was stable over the inclusion period with an annual percentage change (APC) of only - 0.01%. The 5-year overall survival (OS) and relative survival (RS) were 24.5 and 32.4%, respectively. Relative survival did not increase over time. The addition of adjuvant radiotherapy to surgery was not associated with a higher OS and RS compared to surgery alone.Sinonasal mucosal melanoma is a rare disease with stable incidence rates in the Netherlands between 2001 and 2021. There has been no improvement in survival over the course of the inclusion period. The study reaffirms that adjuvant radiotherapy does not seem to improve patient outcomes. Given the generally poor outcomes for SNMM patients, novel therapeutic options ought to be considered in order to improve care.
Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. w.f.j.scheurleer-3@umcutrecht.nl.
Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Comprehensive Cancer Center The Netherlands (IKNL), Department of Research and Development, Utrecht, The Netherlands.
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Comprehensive Cancer Center The Netherlands (IKNL), Department of Research and Development, Utrecht, The Netherlands.Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands.
Sinonasal mucosal melanoma in The Netherlands between 2001 and 2021: a clinical and epidemiological overview of 320 cases.

The recent approval of Dupilumab has profoundly revolutionized the management of patients affected by severe and recalcitrant Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). However, a review that summarizes the results of real-life studies and compares them to phase 3 studies SINUS-24 and 52 is still lacking.A search of all real-life studies published from 2019 to 2023 was performed. Patients characteristics at baseline and 6 and 12 months after starting Dupilumab were extracted and compared to those from phase 3 trials: age, sex, smoking habits, comorbid asthma and aspirin-exacerbated respiratory disease (AERD), previous endoscopic sinus surgery (ESS), hematic eosinophils and total IgE, NasalAQ2 Polyps Score (NPS), smell, SNOT-22, adverse events (AEs), and response to treatment.15 papers were included with an overall number of 1658 patients. A higher rate of comorbidities and previous ESS was found in patients from real-life studies. In addition, they had worse smell and SNOT-22 at baseline compared to patients from SINUS-24 and 52. Comorbid and post-ESS patients tended to have a faster NPS and SNOT-22 improvement, although the absolute values were not clinically relevant. A more extensive surgery and a number of ESS ≥ 2 were related to worse olfactory outcomes, probably due to iatrogenic damage. No correlation was found between hematic eosinophils and outcomes. AEs were reported by 12.4% of patients and 2.2% had to discontinue dupilumab. Weight gain was an emergent AE (0.8%), probably related to the restored sense of smell and taste. Non-responders were 3.5% and they were switched to systemic steroid, ESS, or another biologic.Despite some differences in prescription criteria between countries, dupilumab was demonstrated to be effective even in the real-life scenario. However, emerging AEs and possible unknown long-term AEs of a likely lifelong therapy should be considered.
Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla, 3 - 50134, Florence, Italy.Department of Otorhinolaryngology, Meyer Children's Hospital IRCCS, Florence, Italy.
Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla, 3 - 50134, Florence, Italy.
Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla, 3 - 50134, Florence, Italy. pietro.orlando@unifi.it.
Department of Immunology, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy.
Department of Otorhinolaryngology, Meyer Children's Hospital IRCCS, Florence, Italy.Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla, 3 - 50134, Florence, Italy.Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Efficacy and safety of dupilumab in the treatment of CRSwNP in the real-life setting: a review of the literature.

Malignant otitis externa (MOE) is a rare form of invasive osteomyelitis of the external ear canal. It is typically caused by Pseudomonas aeruginosa in immunocompromised patients. The diagnosis is clinical, and the initial treatment involves systemic antibiotics or antifungal therapy. Surgery is usually only considered when medical treatment has failed. Although hyperbaric oxygen therapy (HBOT) is recommended for refractory osteomyelitis, there are no specific guidelines for MOE.This is a retrospective study that evaluates clinical data, treatment, and results obtained in patients diagnosed with MOE treated with HBOT at the Pedro Hispano Hospital between 2007 and 2022.During the study period, fifteen patients diagnosed with MOE were admitted for treatment with HBOT. All patients received antibiotic and/or antifungal therapy, and three required surgical intervention before starting HBOT. The pathology was successfully managed on all patients.HBOT may be an effective adjuvant treatment option in patients with MOE but it lacks robust scientific evidence. However, its therapeutic value should not be underestimated due to the good results and few adverse effects reported in recent retrospective studies and case reports.
Department of Otorhinolaryngology, Unidade Local de Saúde de Matosinhos, Hospital Pedro Hispano, Rua de Santo António, Lote 14, São Pedro do Sul, Porto, Portugal. pedrommarquesgomes@hotmail.com.
Department of Otorhinolaryngology, Unidade Local de Saúde de Matosinhos, Hospital Pedro Hispano, Rua de Santo António, Lote 14, São Pedro do Sul, Porto, Portugal.
Department of Hyperbaric Medicine, Unidade Local de Saúde de Matosinhos, Hospital Pedro Hispano, Porto, Portugal.
Hyperbaric oxygen therapy in malignant otitis externa: a retrospective analysis.

The internal auditory canal (IAC) plays a key role in lateral skull base surgery. Although several approaches to the IAC have been proposed, endoscope-assisted transcanal corridors to the IAC have rarely been studied. We sought to provide a step-by-step description of the transcanal transpromontorial approach to the IAC and analyze anatomic relationships that might enhance predictability and safety of this approach.Ten cadaveric specimens were dissected and the extended transcanal transpromontorial approach to the IAC was established. Various morphometric measurements and anatomic landmarks were reviewed and analyzed.The proposed technique proved feasible and safe in all specimens. There was no inadvertent injury to the jugular bulb or internal carotid artery. The chorda tympani, a key landmark for the mastoid segment of the facial nerve, was identified in all dissections. The spherical recess of the vestibule and middle turn of cochlea are important landmarks for identification of the labyrinthine segment of the facial nerve. Identification of all boundaries of the working area is also essential for safe access. Among various morphometric measurements, the modiolus-IAC angle (≈ 150°) proved particularly consistent; given its ease of use and low variability, we believe it could serve as a landmark for identification and subsequent dissection of the IAC.The extended transcanal transpromontorial approach to the IAC is feasible and safe. Relying on anatomic landmarks to ensure preservation of the involved neurovascular structures is essential for a successful approach. The modiolus-IAC angle is a consistent, reproducible landmark for IAC identification and dissection.
Department of Otorhinolaryngology, Hospital da PUC-Campinas, Campinas, Brazil. jppvalente@gmail.com.
Department of Otorhinolaryngology and Ophthalmology, FMUSP, São Paulo, Brazil.
Department of Otorhinolaryngology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.
The endoscopic transcanal approach to the internal auditory canal: an anatomic study.

The aim of the present study was to objectively and subjectively compare the preoperative and postoperative aesthetic and functional outcomes of the correction of crooked noses using a suture technique we call nasal axis lateralization suture (NALS) .A total of 36 patients who had preoperative and postoperative photographs taken and who completed the Rhinoplasty Outcome Evaluation (ROE) questionnaire were included in the study.Crooked noses were divided into two groups: C-shaped (17 patients) and I-shaped (19 patients). The preoperative and postoperative nasal axis angles were 145.3 ± 11.9 and 178.5 ± 3.3, respectively, in C-shaped nasal deviation. In I-shaped nasal deviation, on the other hand, the preoperative nasal axis angle was 8.8 ± 2.8, while the postoperative nasal axis angle was 1.4 ± 2.4. In terms of the ideal axis percentage before and after surgery, a significant difference was found between the C-shaped and I-shaped nasal deviation patient groups (p < 0.05). While there was a significant improvement in both groups in the evaluation based on the ROE questionnaire, satisfaction was much higher in the C-shaped nasal deviation group. In both groups, the ROE values of functional and aesthetic outcomes were significantly different compared to the preoperative values of both groups (p < 0.005).NALS can be used as an alternative technique to correct both I-shaped and C-shaped nasal axis deviations.
Otorhinolaryngology and Head & Neck Surgery Department, Sehit Prof. Dr. İlhan Varank Training and Research Hospital, Emek Mahallesi, Namık Kemal Cad. No:54, Sancaktepe, 34785, Istanbul, Turkey.
Otorhinolaryngology and Head & Neck Surgery Department, Sehit Prof. Dr. İlhan Varank Training and Research Hospital, Emek Mahallesi, Namık Kemal Cad. No:54, Sancaktepe, 34785, Istanbul, Turkey. beyza.akcan.1996@gmail.com.
Nasal axis lateralization suture technique in crooked nose.

VA Puget Sound Health Care System, Seattle, WA, United States of America; University of Washington, Seattle, WA, United States of America; Cardiac Care Outcomes Assessment Program, Seattle, WA, United States of America. Electronic address: jdoll@uw.edu.
VA Puget Sound Health Care System, Seattle, WA, United States of America; University of Washington, Seattle, WA, United States of America; Cardiac Care Outcomes Assessment Program, Seattle, WA, United States of America.
University of Colorado School of Medicine, Aurora, CO, United States of America.
University of Colorado School of Medicine, Aurora, CO, United States of America; CART Program, Office of Quality and Patient Safety, Veterans Health Administration, Washington DC, United States of America; Rocky Mountain Regional VA Medical Center, Aurora, CO, United States of America.
Cardiac Care Outcomes Assessment Program, Seattle, WA, United States of America; Pulse Heart Institute, Tacoma, WA, United States of America.
Cardiovascular revascularization medicine : including molecular interventions
Perceived usefulness of percutaneous coronary intervention feedback mechanisms.

To compare the effectiveness of the Endolymphatic duct blockage (EDB) and intratympanic methylprednisolone(ITMP) injection to control refractory Ménière's disease(MD) symptoms and evaluate their impact on hearing level.Retrospective study in a tertiary care center.36 received ITMP injection and 52 EDB. Mean outcome measures at 24 months included vertigo control, tinnitus, aural fullness and hearing level: pure-tone average (PTA), bone conduction average(BCA) and speech discrimination score(SDS).At 24 months postoperatively, 90.4% of the EDB group had complete control of vertigo and 43.4% of the ITMP group (p = 0.001). There was no significant difference in tinnitus or aural fullness control (p = 0.34 and p 0.21 respectively). In each group, the drop in tinnitus and aural fullness frequency at 24 months were significant for EDB (p = 0.03; p < 0.001 respectively) and for ITMP group in tinnitus (p = 0.03) but not aural fullness (p = 0.063). At 24 months, PTA, BCA and SDS were significantly worst in the ITMP group when compared to preoperative levels (p = 0.038, p = 0.027, p = 0.016). PTA in the EDB group was stable with no difference compared to ITMP group (p = 0.48). BCA and SDS in the EDB group were stable and better than the ITMP group (p = 0.032; p = 0.036). In each group, vestibular paresis was not significantly different before (p = 0.06) and after treatment (p = 0.68).EDB is more effective than the ITMP for controlling the vertigo symptoms of Ménière's disease and in preserving hearing function. It is a novel surgical technique with promising results for a complete treatment of Ménière's disease. ITMP decreases the frequency and the severity of the symptoms but only control vertigo in 27.8% of cases.
University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, QC, Canada. issam.saliba@umontreal.ca.Division of Otolaryngology-Head and Neck Surgery, University of Montreal Hospital Centre (CHUM), 1051 Sanguinet St, Montreal, QC, Canada. issam.saliba@umontreal.ca.
University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, QC, Canada.Division of Otolaryngology-Head and Neck Surgery, University of Montreal Hospital Centre (CHUM), 1051 Sanguinet St, Montreal, QC, Canada.
University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, QC, Canada.
Endolymphatic duct blockage surgery vs. intratympanic steroids for treatment of refractory Ménière's disease.

In recent years, new techniques have been added to cholesteatoma surgery, and established microsurgical approaches are being reconsidered. This study aims to present the importance of individualized decision-making for the selection of an intact canal wall (CWU) or canal wall down (CWD) surgical procedure for each patient.Using the ChOLE classification we categorized 264 operations retrospectively. 162 CWU and 102 CWD surgeries were performed. We focus to determine why a CWD procedure was chosen quite frequently despite some low-stage cases. Furthermore, we evaluated recidivism and hearing outcomes.Smaller cholesteatomas (Ch-stage 1a, 1b & 2a) were found in 182 patients (70%), ossicular chain status feasible for straightforward reconstruction (O-stage 0, 1 & 2) was present in 186 patients (70%), minor complications due to the cholesteatoma (L-stage 1) were infrequent with 28 cases (11%) and a well-pneumatized mastoid was found in 144 cases (55%). Recidivism rates were low (7%) without any difference in both groups and a mean follow-up time of 4 years and 8 months. In primary surgeries there was a significant difference (p < 0.05) in postoperative mean air-bone gap (ABG) between CWU (17dB) and CWD (27dB).The main goals of cholesteatoma surgery remain the avoidance of recidivism and optimal hearing rehabilitation. We recommend a tailored approach in the treatment of cholesteatomas and not a dogmatic one. Surgeons should not hesitate to perform a CWD procedure if required. Performed correctly it results in a dry ear and CWD surgery should remain in the skill set of the otologic surgeon.
Department of Otorhinolaryngology/Head and Neck Surgery, Luzerner Kantonsspital, Spitalstrasse 16, Luzern, 6000, Switzerland. f.kostadinov@gmx.ch.
Department of Otorhinolaryngology/Head and Neck Surgery, Luzerner Kantonsspital, Spitalstrasse 16, Luzern, 6000, Switzerland.
A tailored approach in cholesteatoma surgery.

This study aimed to investigate the etiology of hearing loss, including genetic variants, in individuals who underwent cochlear implantation (CI) in their teens to thirties. It also sought to analyze post-CI speech performance and identify prognostic factors affecting CI outcomes in this age group.We conducted a retrospective review of 421 cochlear implant patients at Seoul National University Bundang Hospital, focusing on 63 subjects aged 10-39 years who underwent their first CI by a single surgeon between July 2018 and June 2022. The study included audiologic evaluation, molecular genetic testing, and analysis of speech performance post-CI. Statistical analyses were performed using SPSS 25 and GraphPad Prism 7.Among 63 participants (M:F, 24:39), nine underwent CI in their teens, 24 in their 20 s, and 30 in their 30 s. Most of them (40, 63.5%) had postlingual deafness. The study found that 65.2% (40/63) of subjects received a genetic diagnosis, with DFNB4 being the most common etiology (37.5%, 15/40). Post-CI speech evaluation showed an average sentence score of 80% across all subjects. Factors such as the onset of hearing loss, duration of deafness (DoD), and preoperative Speech Intelligibility Rating (SIR) significantly influenced CI outcomes. Notably, longer DoD was associated with poorer CI outcomes, but this did not affect individuals with postlingual hearing loss as much.The study concludes that in individuals aged 10-39 undergoing CI, the onset of hearing loss and preoperative SIR are critical predictors of postoperative outcomes. CI is recommended for those with postlingual hearing loss in this age group, irrespective of the DoD. The study highlights the importance of genetic factors especially DFNB4 in hearing loss etiology and underscores the value of the relatively easy-to-evaluate factor, preoperative SIR in predicting CI outcomes.
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. choiby2010@gmail.com.Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea. choiby2010@gmail.com.
Clinical characteristics and hearing loss etiology of cochlear implantees undergoing surgery in their teens, 20s, and 30s.

Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. drmustafaguven@comu.edu.tr.
Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Correction to: The Neuroprotective Effect of Coumaric Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats.

Examination of the scientific literature on cholesteatoma from past to present using bibliometric methods.A total of 2353 articles on cholesteatoma between 1980 and 2023 were obtained from the Web of Science database and statistically analysed using bibliometric techniques.The journals with the highest number of contributions to the literature were Otology & Neurotology (n = 192), Acta Oto-Laryngologica (156) and Laryngoscope (149). The most impactful journals based on h-index and total citation (TC) counts were Laryngoscope (h:36, TC: 4241), Otology & Neurotology (29, 3141), and American Journal of Otology (26, 2071) respectively. The most prolific author was Kojima H. (n = 49). According to the findings of the Reference Publication Year Spectroscopy (RPYS) analysis, there has been a significant increase in academic interest in Cholesteatoma since its first description in 1959, particularly following the expansion of its definition in 1977. Subsequently, the trend of increased interest has risen rapidly in later years, with notable peaks in research intensity observed in 1989, 2006, and 2011. The highest academic trend occurred in 2006. In recent years, trending topics have included innovative approaches such as diagnostic and imaging methods particularly alongside technological developments, endoscopic surgery, recurrence and complications, prognosis and quality of life, artificial intelligence, and obliteration.In conclusion, the evolution of cholesteatoma and its research priorities reveal temporal shifts and emerging areas of interest over time. Primarily, diagnosis, treatment, and surgical approaches remain central. Additionally, research has expanded to encompass developments in surgical techniques, imaging modalities, cellular biology, pathology, and molecular mechanisms.
Private Practitioner, Otolaryngology, Çorum, Turkey. bnumanugurlu@gmail.com.Department of Otorhinolaryngology, Faculty of Medicine , Hitit University, Çorum, Turkey. bnumanugurlu@gmail.com.
Department of Otorhinolaryngology, Faculty of Medicine , Hitit University, Çorum, Turkey.
Exploring trends and developments in cholesteatoma research: a bibliometric analysis.

This study aims to evaluate the validity and reliability of tubomanometry (TMM) in diagnosing obstructive Eustachian tube dysfunction (OETD) before balloon Eustachian tuboplasty (BET).A prospective cohort study was conducted, involving 25 patients with sinonasal pathology, 75 patients with middle ear disease, and 25 healthy subjects, totaling 250 ears. All participants underwent comprehensive physical examinations, including TMM, nasal videoendoscopy, otoendoscopy, Valsalva maneuver (VM), tympanometry, and audiometry. Additionally, various scales such as ETDQ-7 and ETS-7 were employed. Tympanometry served as the gold standard for assessing OETD, and comparisons were made among the measures across the three groups.Among the 125 participants, 44.8% (n = 56) were female, and 55.2% (n = 69) were male, with ages ranging from 19 to 93 years (M = 48.5; SD = 15.6). In our study, VM demonstrated high sensitivity (86.3%) when tympanometry was considered the gold standard. Conversely, TMM, ETDQ-7, and ETS-7 exhibited high specificity, with ETDQ-7 showing the highest specificity (87.4%). Regarding TMM, all R values in patients within the middle ear disease group were pathological (R > 1).TMM has exhibited notable specificity as a diagnostic tool compared to tympanogram and VM. Nonetheless, the combination of TMM and ETDQ-7 has enabled us to conduct a diagnostic assessment with high sensitivity and specificity for chronic OETD diagnosis.
Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos, Carretera del Molino 2, Fuenlabrada, 28942, Madrid, Spain.Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario La Zarzuela, Madrid, Spain.
Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos, Carretera del Molino 2, Fuenlabrada, 28942, Madrid, Spain.
Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario de La Princesa, Madrid, Spain.
Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos, Carretera del Molino 2, Fuenlabrada, 28942, Madrid, Spain. guillermo.plaza@salud.madrid.org.Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario La Zarzuela, Madrid, Spain. guillermo.plaza@salud.madrid.org.
Assessing the usefulness of tubomanometry as a diagnostic tool in Eustachian tube dysfunction.

Study the efficacy of olfactory training in smell recovery.An extensive search was performed through different databases in order to find articles analyzing the efficacy of olfactory training as a treatment for olfactory dysfunction. Methodological quality of primary studies within the final sample was assessed following PRISMA guidelines. Standardized mean differences in pre-post olfactory training groups, and also in experimental-control and pre-follow up if possible, were computed by Hedges' g effect size statistic. Each effect size was weighted by its inverse variance.Final sample was composed of 36 articles (45 pre-post effect sizes). Contrasts were performed separately for odor identification, odor discrimination, odor threshold and general olfactory function. Moderate to large and heterogeneous effect was obtained for olfactory function (g = 0.755, k = 45, SE = 0.093, CI 95% = [0.572, 0.937]), different moderators had a significant effects, such as, training duration, age and anosmia diagnosis.Olfactory training was found to have a positive and significant effect on rehabilitating the olfactory function.
Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223, Pozuelo de Alarcón, Spain.
Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223, Pozuelo de Alarcón, Spain. mldelgad@ucm.es.
The efficacy of olfactory training in improving olfactory function: a meta-analysis.

This study aimed to investigate the clinical and histopathological characteristics of sinonasal seromucinous hamartomas (SHs).Eight patients with sinonasal SH and treated at a tertiary hospital between November 2005 and September 2023 were included. Additionally, a systematic review of published articles was conducted, analyzing 48 cases of SH described in the literature.Among the eight patients treated at our institution, tumors originated from the posterior nasal cavity in four patients and middle turbinate and middle meatus were the primary origin in two patients each. Coexistence of inflammatory nasal polyps (NPs) was observed in four cases. Histopathologically, four patients exhibited focal respiratory epithelial adenomatoid hamartoma (REAH) features, and low-grade dysplasia was found in one patient. A combined analysis with previous literature revealed that 46.3% of all cases originated in the anterior nasal cavity. The proportions of cases accompanied by NPs and those with focal REAH features were 20.5% and 39.1%, respectively. Additionally, the frequencies of cases exhibiting dysplastic features (5.4%) and recurrence (2.1%) were low. Remarkably, tumors originating from the anterior region tended to have a higher frequency of dysplasia than those originating from the posterior region, although this difference was not statistically significant (p = 0.0996).Patients with sinonasal SH showed favorable treatment outcomes following surgical resection. Focal REAH features and accompanying NPs were frequently observed. A substantial proportion of cases originate in the anterior nasal cavity, and these tumors may exhibit a high tendency for dysplasia.
Department of Otorhinolaryngology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Department of Otorhinolaryngology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Otorhinolaryngology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.The Korea Mouse Phenotyping Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Otorhinolaryngology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. msrha@yuhs.ac.
Sinonasal seromucinous hamartoma: a single institution case series combined with a narrative review of the literature.

To investigate a possible link between acute Epstein-Barr virus infection and Lemierre syndrome, a rare yet life-threatening infection.A systematic review was conducted adhering to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnosis criteria for Lemierre syndrome were established, and data extraction encompassed demographic data, clinical, and laboratory information.Out of 985 initially identified papers, 132 articles were selected for the final analysis. They reported on 151 cases of Lemierre syndrome (76 female and 75 male patients with a median of 18 years) alongside interpretable results for Epstein-Barr virus serology. Among these, 38 cases (25%) tested positive for acute Epstein-Barr virus serology. There were no differences in terms of age, sex, or Fusobacterium presence between the serologically positive and negative groups. Conversely, instances of cervical thrombophlebitis and pulmonary complications were significantly higher (P = 0.0001) among those testing negative. The disease course was lethal in one case for each of the two groups.This analysis provides evidence of an association between acute Epstein-Barr virus infection and Lemierre syndrome. Raising awareness of this link within the medical community is desirable.
Family Medicine, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.
Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.Clinical Pharmacology Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Della Commenda 9, 20122, Milan, Italy. gregorio.milani@unimi.it.Department of Clinical Sciences and Community Health, Università Degli Studi Di Milano, Milan, Italy. gregorio.milani@unimi.it.
Family Medicine, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.
Epstein-Barr virus as promoter of Lemierre syndrome: systematic literature review.

Histopathological analysis often shows close resection margins after surgical removal of tongue squamous cell carcinoma (TSCC). This study aimed to investigate the agreement between intraoperative 3D ultrasound (US) margin assessment and postoperative histopathology of resected TSCC.In this study, ten patients were prospectively included. Three fiducial cannulas were inserted into the specimen. To acquire a motorized 3D US volume, the resected specimen was submerged in saline, after which images were acquired while the probe moved over the specimen. The US volumes were annotated twice: (1) automatically and (2) manually, with the automatic segmentation as initialization. After standardized histopathological processing, all hematoxylin-eosin whole slide images (WSI) were included for analysis. Corresponding US images were found based on the known WSI spacing and fiducials. Blinded observers measured the tumor thickness and the margin in the caudal, deep, and cranial directions on every slide. The anterior and posterior margin was measured per specimen.The mean difference in all measurements between manually segmented US and histopathology was 2.34 (SD: ±3.34) mm, and Spearman's rank correlation coefficient was 0.733 (p < 0.001). The smallest mean difference was in the tumor thickness with 0.80 (SD: ±2.44) mm and a correlation of 0.836 (p < 0.001). Limitations were observed in the caudal region, where no correlation was found.This study shows that 3D US and histopathology have a moderate to strong statistically significant correlation (r = 0.733; p < 0.001) and a mean difference between the modalities of 2.3 mm (95%CI: -4.2; 8.9). Future research should focus on patient outcomes regarding resection margins.
Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek, Antoni van Leeuwenhoek, Amsterdam, The Netherlands. n.bekedam@nki.nl.Academic Centre of Dentistry Amsterdam, Vrije Universiteit, Gustav Mahlerlaan 3004, Amsterdam, 1081 LA, The Netherlands. n.bekedam@nki.nl.Department of Head and Neck Surgery and Oncology, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. n.bekedam@nki.nl.
Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Department of Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Department of Head and Neck Surgery and Oncology, Cancer Institute, Antoni van Leeuwenhoek, Verwelius 3D Lab, Amsterdam, The Netherlands.
Clinical validation of the accuracy of an intra-operative assessment tool using 3D ultrasound compared to histopathology in patients with squamous cell carcinoma of the tongue.

The term petrous bone cholesteatoma (PBC) refers to lesions extending deep to the bony labyrinth via superior, inferior, and posterior cell tracts. PBC is a rare incidence accounting for only 4-9% of petrous bone lesions. Lesions of petrous bone represent a real surgical challenge due to its complex relationship with critical neurovascular structures.To demonstrate our 40-plus years' experience in the management of PBC, depict the clinical features of PBC according to Sanna's Classification, evaluate the postoperative follow-up of surgically treated PBC patients, and determine the recurrence rate.Retrospective medical record review.Medical records of 298 PBC cases operated from the year 1983 to 2024 were thoroughly evaluated.A total of 298 PBC cases were surgically treated at our center. The average age at presentation in this series was 47 years. Males are more affected than females with a male-to-female ratio of 2.2:1. The most common presenting symptoms were hearing loss (84%), tinnitus (48%), and facial nerve paralysis (45%). Mixed hearing loss (41%) was the commonest audiometric pattern of hearing loss followed by conductive hearing loss (26%) and profound sensorineural hearing loss (4%) and a total of 86 (29%) had anacusis at presentation. On preoperative facial nerve function examination, 133(45%) of patients had various degrees of paresis and complete paralysis whereas 55% had normal HB-I function. The commonest degree of paresis noted was HB-III (18%) followed by HB-VI (5%). A total of 150 (50%) patients had previous otologic surgery and two-thirds of these cases had two or more prior otologic surgeries. According to Sanna's PBC Classification system, we identified that the supralabyrinthine class (44%) is the commonest of all classes followed by massive (33%), infralabyrinthine-apical (9%), infralabyrinthine(8%), and apical (5%) classes in that order. However, only ten patients had congenital type of PBC. Extension to clivus, sphenoid, nasopharynx, intradural space, and occipital condyle was found in 8, 2, 1, and 2 cases respectively. The most commonly used surgical approaches at our center were TO, MTCA with rerouting of the facial nerve, and TLAB with external auditory canal (EAC) closure. Postoperative complications were minimal and the duration of follow-up ranged from one to 458 months with a mean duration of 65 months. Residual lesions were evident in 11 cases (3.7%), with the surgical cavity, middle and posterior fossa dura, and jugular bulb being the commonest sites.Petrous bone cholesteatoma represents diagnostically and surgically challenging lesions of temporal bone which are usually frustrating to the treating surgeon. A high index of clinical suspicion, thorough clinical evaluation examination, and preoperative radiologic evaluation make the diagnosis easier. Preoperative anatomic classification of the lesion enables the physician to choose the appropriate surgical approach. Sanna's classification is widely used to classify PBC in relation to the labyrinthine block. Radical disease removal should always come before hearing preservation. Cavity obliteration is the solution to the problems related to a large cavity. Finally, advancements in lateral skull base approaches create adequate surgical access for the complete removal of the lesion with excellent control of critical neurovascular structures.
Department of Otolaryngology-Head and Neck Surgery, College of Health Sciences, Addis Ababa University, Ethiopia, Department of Otology and Skull Base Surgery, Gruppo Otologico, Piacenza, Italy. melcol.hailu@aau.edu.et.
Department of Otology and Skull Base Surgery, Gruppo Otologico, Piacenza, Italy.
Management of Petrous Bone Cholesteatoma: The Gruppo Otologico Experience.

Revision stapes surgery is a challenging procedure performed in relatively small numbers compared to other middle ear procedures. Despite numerous data on hearing results of different middle ear surgeries, the audiological standards for successful outcome of this procedure are still not clarified. On the basis of well-documented data, we wanted to determine what the expected audiological results and complications are after revision stapes surgery in order to set a realistic threshold for surgical success.After the protocol registration in the PROSPERO database, a systematic review was performed in multiple databases (PubMed, Cochrane, Web of Science, Scopus, ScienceOpen, ClinicalTrials.gov, Google Scholar) according to PRISMA guidelines. Twelve articles were reviewed according to the inclusion criteria. A total of 1032 cases were obtained for evaluation. A modified version of Newcastle-Ottawa Scale (NOS) was used to assess publication quality.Average air-bone gap (ABG) gain was 17.3 dB, average air conduction (AC) gain was 17.5 dB. The average postoperative air-bone gap was 11.1 dB. The postoperative ABG distribution was the following 0-10 dB: 53.3%, > 10-20 dB: 28.2%, > 20 dB: 18.5%. SNHL as a surgical complication was described in a total of 17 cases (1.6%), no equilibrium disorder was reported.The pooled data suggest that revision stapes surgery is an effective solution after failure of previous stapes surgery. However, the results are clearly inferior to those of primary stapedotomies. Hence, we need to apply different expectations and use different standards in the indication and evaluation of this type of surgery.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis Egyetem (Semmelweis University), Szigony Utca 36, Budapest, 1083, Hungary. szekely.laszlo1@semmelweis.hu.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis Egyetem (Semmelweis University), Szigony Utca 36, Budapest, 1083, Hungary.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis Egyetem (Semmelweis University), Szigony Utca 36, Budapest, 1083, Hungary.Department of Voice, Speech and Swallowing Therapy, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.
Audiological outcomes after revision stapes surgeries: a systematic review.

Chronic rhinitis is when the nasal passages become inflamed and irritated, causing symptoms like nasal congestion, runny nose, sneezing, and postnasal drip that last for at least 12 weeks. While various medical treatments are available for chronic rhinitis, studies have shown that patients often do not comply with the treatment or report that it is ineffective. Cryotherapy for the nasal mucosa is a surgical option that has shown promise for these patients, with acceptable side effects.Our goal is to evaluate the existing literature regarding the effectiveness and safety of cryotherapy as a treatment for chronic rhinitis.We searched four electronic databases for relevant studies. Data were extracted from the included studies after screening procedures. Using the random effect model, we calculated the pooled mean difference (MD) for our continuous outcomes and pooled proportions for categorical outcomes. The I2 test was used to detect heterogenicity. Randomized controlled trials (RCTs) were assessed for methodological quality using the Cochrane risk of bias assessment tool 2, while observational studies and single-arm studies were assessed using the National Institutes of Health's tools.Our study comprised 21 studies; eighteen were eligible for analysis, with 1663 patients with chronic rhinitis. All of our assessed outcomes showed improvement with cryotherapy from their baseline status. Our pooled MDs for Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Nasal Obstruction Symptom Evaluation (NOSE) scores were as follows: ( - 3.58, 95% CI [ - 3.80, - 3.37], p < 0.001), ( - 1.48, 95% CI [ - 1.68, - 1.27], p < 0.001), and ( - 26.65, 95% CI [ - 33.98, - 19.31], p < 0.001), respectively. Regarding nasal obstruction and rhinorrhea, cryotherapy showed effectiveness in 61% and 52% of patients in the complete relief subgroup and 26% and 34% in the < 50%-relief subgroup, respectively.We observed significant improvement in our measured outcomes as rTNSS, RQLQ, and NOSE scores compared to the baseline state, demonstrating the cryotherapy's efficacy. This improvement was consistent in all subsequent follow-up periods. However, we need more high-quality RCTs for stronger evidence to be generalized.
Department of Otolaryngology Head and Neck Surgery, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.Department of Otolaryngology Head and Neck Surgery, Prince Mohammed Medical City, Jouf, Kingdom of Saudi Arabia.
Department of Otolaryngology Head and Neck Surgery, Collage of Medicine, Qassim University, P.O. Box 6655, Buraidah, 51452, Qassim, Kingdom of Saudi Arabia. m.alenezi@qu.edu.sa.
Department of Otolaryngology Head and Neck Surgery, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.Department of Otolaryngology Head and Neck Surgery, Matrernity and Pediatric Hospital, Rafha, Kingdom of Saudi Arabia.
Department of Otolaryngology Head and Neck Surgery, Collage of Medicine, Qassim University, Buraidah, Kingdom of Saudi Arabia.
Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis.

Scar formation after neck surgery is a frequent concern, impacting patients both physically and psychologically. Cosmetic appearance plays a crucial role in assessing surgical success. At present, the evolving medical technologies introduces innovations like Geometric Electron Modulation (GEM) electrocautery. GEM technology offers potential benefits such as reduced thermal injury and consistent heat emission during surgery compared to conventional electrocautery.To compare the difference between postoperative neck scars from the surgical blade as the gold standard and geometric electron modulation electrocautery.A randomized controlled study was performed on the patients who were diagnosed with surgical conditions requiring neck surgery at the Department of Otolaryngology Head and Neck Surgery, King Chulalongkorn Memorial Hospital, from 2023 to 2024. The Patient and Observer Scar Assessment Scale was utilized to assess scar appearance at 1 and 3 months following the surgery, and the amount of blood loss during incision was recorded.22 patients were enrolled to this study. At 1-month follow-up, we saw significant difference between GEM (20.32 ± 4.11) and the surgical blade (23.27 ± 4.59) (P = 0.008) from POSAS, patient scale but no significant difference in doctor scale, (GEM 21.55 ± 7.34, surgical blade 24.27 ± 7.88, P = 0.155). At 3-month follow-up, there were no significant difference between the groups both doctor (GEM 16.45 ± 4.62, surgical blade 17.65 ± 4.50, P = 0.411) and patient scale (GEM 13.15 ± 2.96, surgical blade 14.05 ± 3.33, P = 0.328).GEM electrocautery had a superior scar outcome to a surgical blade at 1 month from the patient perspective. There was also significantly less blood loss in GEM compared with the surgical blade.
Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Pathumwan, Bangkok, Thailand.
Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Road, Pathumwan, Bangkok, Thailand. wisarut.samuck@gmail.com.
The short-term outcomes of surgical scars in head and neck surgery comparing between surgical blade and geometric electron modulation electrocautery.

Numerous treatment modalities have been suggested for managing tinnitus. Tailor-Made Notched Music Training (TMNMT) is a viable strategy in music therapy for tinnitus management. Many research studies have examined the effectiveness and potential benefits of this intervention. This study aims to assess the effectiveness of TMNMT in treating chronic tinnitus.This systematic review and meta-analysis study used a research methodology that covered up until February 2023. The search was conducted across academic databases including Google Scholar, PubMed, Scopus, and Web of Science. A total of 234 papers were evaluated, and seven relevant clinical trials were included.The meta-analysis, which included five studies using the tinnitus handicap inventory (THI), showed no statistically significant effect of TMNMT on tinnitus handicap after 3 and 6 months of intervention (dppc2: - 0.99, 95%CI - 2.94 to 0.96; I2 = 79.96%, p = 0.00), (dppc2 - 1.81, 95%CI - 5.63 to 2.01; I2 = 79.96%, p = 0.00). However, four out of five studies using the total Visual Analogue Scale (VAS) or its subscale showed positive effects of TMNMT on chronic tinnitus. Unfortunately, there were not enough articles to conduct a meta-analysis on this outcome.Although the meta-analysis did not show a statistically significant effect of TMNMT on tinnitus handicap, the large effect size observed after at least 3 months of intervention suggests that this method may potentially decrease tinnitus handicap if more studies are conducted. Due to the limited number of studies, subgroup analysis could not be performed to analyze potential causes of heterogeneity. Therefore, further high-quality clinical trials are necessary to draw a definitive conclusion and evaluate the impact of different variables, techniques, and outcomes.
Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Enghelab Street, Pich-E-Shemiran, Tehran, Iran.
Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Enghelab Street, Pich-E-Shemiran, Tehran, Iran. v-rahimi@sina.tums.ac.ir.
Department of Communication Science & Disorders, University of Iowa, Iowa, USA.
Efficacy of tailor-made notched music training (TMNMT) in the treatment of tinnitus: a systematic review and meta-analysis.

Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a common disease, which was previously approached with sinus surgery or systemic corticosteroids. The advent of biological therapies radically changed the approach to this disease. On the other hand, there is scarce scientific evidence of how specific subsets of patients respond to this treatment.this is a monocentric, prospective study investigating the long-term efficacy on biweekly 300 mg dupilumab therapy in CRSwNP, prescribed to 61 patients. Patients were evaluated at baseline and every 2 months for the first 6 months, then at 9, 12, 16, 20 and 24 months.dupilumab proved to be an effective treatment, neatly improving both subjective and objective measurements in CRSwNP. The main finding of the study is the difference between specific subgroups of patients: while the overall response is similar, patients with Th2 comorbidities such as asthma and atopy tend to reach a stable response later, with the improvement ongoing even after 6 months of therapy, while non-asthmatic, non-atopic patients attain an earlier stability in response.dupilumab provides an excellent long-term control of CRSwNP, but the response in asthmatic and atopic patients appears to be different and delayed when compared to non asthmatic and non atopic ones.
Division of Head and Neck Department, Otorhinolaryngology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Otorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Paris, France.
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, 20132, Milan, Italy.
Department of Otolaryngology-Head and Neck Surgery, Ente Ospedaliero Cantonale, Ospedale Regionale di Lugano, Lugano, Switzerland. matteotrimarchi@gmail.com.Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. matteotrimarchi@gmail.com.
Dupilumab: a delayed response in asthmatic and atopic patients treated for chronic rhinosinusitis with nasal polyps.

Dysphagia is common in people with Parkinson's disease (PD). Yet, literature describing swallow function in PD using high-resolution manometry is limited. This study explored swallowing pressure metrics for varied bolus conditions in people with PD.A solid-state unidirectional catheter was used to acquire manometric data for triplicate swallows (5 ml, 10 ml, 20 ml; IDDSI 0, 2 & 4). Penetration-aspiration severity was rated during videofluoroscopy. Patient-reported measures included PDQ-8: Parkinson's Disease Questionnaire-8 and EAT-10: Eating Assessment Tool-10. Quantitative manometric swallow analysis was completed through Swallow Gateway™. Metrics were compared to published normative values and generalized linear model tests explored modulatory effects.21 participants (76% male; mean age 69.6 years, SD 7.1) with mild-moderate severity PD were studied. Two patients (9%) aspirated for single bolus thin liquid and paste trials and 15 patients (73%) scored > 3 EAT-10. Standardized PDQ-8 scores correlated with EAT-10 (p < 0.05). Abnormality in UES relaxation and distension was demonstrated by high UES integrated relaxation pressure and low UES maximum admittance (UES MaxAdm) values across varied bolus conditions. Participants demonstrated abnormally elevated pharyngeal contractility and increased post-swallow upper-esophageal sphincter (UES) contractility for thinner liquid trials. Alterations in volume and viscosity had significant effects on the bolus timing metric-distention to contraction latency. UES peak pressure measures were altered in relation to bolus viscosity.This study identifies early pharyngoesophageal contractile changes in relation to bolus volume and viscosity in PD patients, associated with subtle deterioration of self-reported swallow scores. Manometric evaluation may offer insight into PD-related swallowing changes and help optimize diagnostics and treatment planning.
Speech Science, School of Psychology, The University of Auckland, B072, Level 2, Building 507, Grafton Campus, Park Road, Private Bag 92019, Auckland, New Zealand. fabd416@aucklanduni.ac.nz.
Speech Science, School of Psychology, The University of Auckland, B072, Level 2, Building 507, Grafton Campus, Park Road, Private Bag 92019, Auckland, New Zealand.
Department of Surgery, The University of Auckland, Auckland, New Zealand.
Pharyngeal adaptation to bolus properties in patients with Parkinson's disease.

In this study we investigated the effect of cochlear implantation on tinnitus in patients with post lingual bilateral profound hearing loss.In this retrospective study, 66 post-lingual deaf patients over 18 years old who referred for cochlear implantation and complained of tinnitus were included. Patients were divided into two groups with residual hearing (in frequency 250-500 Hz) and without residual hearing. All data including age, gender, type of implants, type of surgery, cause of the disease, and information on the THI score before cochlear implantation, one month after cochlear implantation and one year after cochlear implantation was recorded and analyzed.Nine patients had residual hearing, while 57 patients did not. After one month and one year, in both groups, the mean THI score has decreased significantly (p-value = 0.001), but there was no significant difference in the mean THI score before surgery and one month and one year after surgery between two groups with and without residual hearing. There was no significant difference in tinnitus severity according to THI-grade between two groups. Also there was no significant difference in THI score and the cause of the hearing loss, type and insertion method of implantation, one month and one year after the surgery between two groups.According to our results, the was no significant correlation between residual hearing and tinnitus score before surgery, one month and one year after the surgery.
Amir-Alam Hospital, Department of Otolaryngology-Head and Neck Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. m.mandegari2015@gmail.com.
The effect of cochlear implantation on tinnitus in patients with post lingual bilateral profound hearing loss.

One of the possible risks of sinonasal malignancy is its possible spread in the orbit. However, there is no clear consensus among the different departments as to whether it is necessary to exenterate the orbit in limited tumorous infiltration of periorbital fat. The purpose of the study was to demonstrate that periorbital infiltration and periorbital fat invasion without involvement of deeper orbital tissues are not the indication of orbital exenteration.Retrospective analysis was performed over a 17-year period of patients undergoing surgical treatment for sinonasal malignancy with histologically verified periorbital infiltration or deeper invasion into the orbit. A total of 32 patients were included in the study. For each group, the following data were analysed: sex, age, preoperative imaging studies, histological findings, site of origin, stage, surgical reconstruction, oncological treatment, survival, cause of death, number of recurrences in the orbit and functional status of preserved eyes.Based on our criteria for orbital exenteration, orbital preservation was feasible in 18 patients. Orbital exenteration was performed in 14 patients with deeper tumor infiltration. There was a statistically insignificant difference in survival between the two groups. The 5-year overall survival (OS) was 44% for the orbital preservation group (only 2 patients died from local tumor recurrence) and 34% for the orbital exenteration group. The groups did not differ in other observed factors other than the extent of orbital infiltration. In 11 (61.1%) patients, vision was without significant change after radiation therapy. In 2 (11.1%) patients, visual function was impaired due to diplopia. 5 (27.8%) patients had severely impaired vision due to optic nerve atrophy after radiation therapy.Our results show a relatively high survival rate in the group of patients with orbital preservation with a high chance of vision preservation, which justifies our approach to orbital preservation even in some tumors with periorbital infiltration.
Department of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine, University Hospital Motol, Charles University, V Uvalu 84, Prague, 150 06, Czech Republic. Stepan.novak@fnmotol.cz.
Department of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine, University Hospital Motol, Charles University, V Uvalu 84, Prague, 150 06, Czech Republic.
Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.
Preservation of orbit in tumor invasion through the periorbita in sinonasal malignancy.

Peri-operative management of nasal cerebrospinal fluid (CSF) leaks is not consensual due to limited evidence. The main aim of this study was to identify key factors in peri-operative management of endoscopic endonasal CSF leak repair among international experts.A 60-item survey questionnaire collected opinions of members of international learned societies of ENT surgeons and neurosurgeons on nasal packing, post-operative instructions, antibiotic prophylaxis, and CSF volume depletion.The survey had 153 respondents (124 otorhinolaryngologists and 29 neurosurgeons). A resting position was recommended by 85% (130/151) of respondents for extended CSF leak of the anterior skull base, mainly in Fowler's position (72% (110/153)). Nasal packing was used by 85% (130/153) of respondents; 33.3% (51/153) used it to stabilize the reconstruction, and 22.2% (34/153) to prevent bleeding. It was usually removed after 48 h in 44.4% of cases (68/153). CSF depletion was considered by 47.1% (72/153) of respondents in case of CSF leak recurrence and by 34.6% (53/153) in cases of increased intracranial pressure. All respondents gave specific postoperative instructions to patients including driving, running, swimming, diving restrictions and flighting restrictions. In subgroup analysis, ENT surgeons more often recommended a resting position than neurosurgeons (71% vs. 37.9% ; p = 0.0008) and prescribed more antibiotics (82.3% vs. 21.4% ; p < 0.0001).Although postoperative management after CSF closure remains challenging and not codified, this international survey revealed some points of consensus concerning resting position and restriction of post-operative activities. Prospective clinical studies must be undertaken to evaluate their efficiency.
Département d'ORL et chirurgie cervico-faciale, Centre Hospitalier Universitaire de Montpellier, Hopital Gui de Chauliac, 80 Avenue Augustin Fliche, Montpellier, 34000, France. valentin_favier@hotmail.com.
Division of Otolaryngology - Head & Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
ENT department - Skull Base Center, Lariboisière University Hospital, Paris, France.
Service de neurochirurgie, chirurgie des adénomes hypophysaires et de la base du crane, Hôpital neurologique Pierre Wertheimer, Hospices civils de Lyon, Bron, France.
Département d'ORL et chirurgie cervico-faciale, Centre Hospitalier Universitaire de Montpellier, Hopital Gui de Chauliac, 80 Avenue Augustin Fliche, Montpellier, 34000, France.
Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'ORL, d'otoneurochirurgie et de chirurgie cervico-faciale, Pierre Bénite cedex, F-69310, France.Université de Lyon, Université Lyon 1, Lyon, F-69003, France.
Service ORL, Chirurgie Cervico-Maxillo-Faciale et Audiophonologie, Centre Hospitalier Universitaire de Poitiers, Poitiers, 86000, France.Laboratoire Inflammation Tissus Epithéliaux et Cytokines (LITEC), UR15560, Université de Poitiers, Poitiers, 86000, France.
Peri-operative management of endoscopic endonasal cerebrospinal fluid leak repair: an international survey.

To evaluate whether trans-thyroid cartilage nerve monitoring for thyroid surgeries is as effective and safe as endotracheal tube monitoring.Fifty-one thyroidectomies (38 hemithyroidectomies and 13 total thyroidectomies, analyzed as two separate hemi-thyroidectomies) were included. Patients undergoing surgery from 6/2020 to 8/2021 were monitored simultaneously with the NIM® Nerve Monitoring System TriVantage™ Electromyography (EMG) endotracheal tube and EMG trans-thyroid cartilage. Electrophysiological responses of 64 vagus and recurrent laryngeal nerves were obtained. Peri-operative evaluation and 12-month post-operative follow-up were conducted to examine nerve function. Wilcoxon signed-rank and Spearman coefficient tests were used to determine whether there were differences between the methods.The average initial amplitude measured with the trans-thyroid cartilage method was higher in the recurrent laryngeal and vagus nerves (p = 0.002, p = 0.003, respectively). The mean difference in EMG amplitude from start to end of surgery for 10 damaged nerves (7 temporary and 3 permanent) differed from intact nerves in both methods and nerves (p < 0.05 for all). Among intact recurrent laryngeal nerves, 20.4% had 20-80% decrease in amplitude in endotracheal tube electrodes and 16.7% in trans-thyroid cartilage electrodes (p = 0.92). All cases with stable EMG signals or with increased EMG amplitude (with both types of electrodes and with both nerves) had normal post-operative vocal function. No significant difference was found between the two methods when measuring the vagus and recurrent laryngeal nerves. No complications occurred when using trans-thyroid cartilage electrodes.Trans-thyroid cartilage nerve monitoring for thyroid surgeries is as effective and safe as the current standard monitoring using an endotracheal tube. During thyroid surgery, patients are monitored to avoid damaging nerves near the vocal cords. This study compared monitoring through a throat tube with the easier method of monitoring outside of the throat to see if it is as effective and safe. No major difference was found between the two methods and there were no problems.
Department of Otolaryngology, Head and Neck Surgery, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, 4428164, Israel. stahlavishai@gmail.com.Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. stahlavishai@gmail.com.
Department of Otolaryngology, Head and Neck Surgery, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, 4428164, Israel.
Department of Otolaryngology, Head and Neck Surgery, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, 4428164, Israel.Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Is trans-thyroid cartilage monitoring as good as endotracheal tube monitoring during thyroidectomy?

Among the complications of parotid surgery, facial palsy is frequent and burdened by high functional and social impact for the patient. There are few data on the efficacy of facial neuromuscular retraining (FNR) in patients with facial palsy after parotid surgery, and no data exist on its impact in timing and extent of recovery.A retrospective study was conducted on patients undergoing FN sparing parotid surgery and suffering from postoperative facial palsy. Among 400 patients undergoing surgery between July 2016 and May 2023, those with the preservation of the FN and onset of facial palsy were selected. Nerve function was evaluated during 2 years follow up using the House-Brackman (H&Bs) and Sunnybrook scales (SBs).A total of 46 patients undergoing partial or total parotidectomy were included. At discharge 18 patients (39,1%) had IV to VI grade paralysis according to the H&Bs and the mean SBs value was 54. At 2 and 6 months after surgery, the average value of Sunnybrook increased to 76.5 and 95.4 respectively. After 12 months no patients with IV to VI grade paralysis were represent in our cohort. Two years after surgery, only five patients (10.9%) had persistent grade II paralysis according to HBs.Our study supports the efficacy of FNR in the rehabilitation of facial paralysis after nerve-sparing parotidectomy. The greater functional improvement is achieved within the first 6 months of rehabilitation. A significant improvement is detected still after 18 months, supporting the importance of long rehabilitation for patients without complete recovery after the first year.
Department of Otolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero - Universitaria di Bologna, Bologna, Italy.Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University di Bologna, Bologna, Italy.
Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy. fedecalva@gmail.com.
Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Patterns and timing of recovery from facial nerve palsy after nerve-sparing parotid surgery: the role of neuromuscular retraining.

Epistaxis is a common condition that affects about 60% of the population in their lifetime, with 6% needing medical attention. Little is known about the epidemiology and risk factors of epistaxis outside the health care system. This study aimed to investigate the prevalence and risk factors of epistaxis in a rural Danish population using data from the Lolland-Falster Health Study (LOFUS).We conducted a cross-sectional survey based on data from LOFUS, a household-based, prospective cohort study in the rural provincial area of Lolland-Falster, Denmark. We enrolled 10,065 participants (≥ 50 years) and collected data on demographics, comorbidities, medication, lifestyle factors, and laboratory parameters. Logistic regressions were used to test for correlations between epistaxis and different risk factors.In total 5.3% of the participants had experienced epistaxis within the past 30 days, and 7.9% had sought medical attention for epistaxis at some point in their lives. We identified several factors that were significantly correlated with increased odds of epistaxis, such as male gender, age group 50-59 years, high BMI (> 25), allergy, diabetes, hypertension, atherosclerosis, angina, and anticoagulant treatment. Excellent or good self-reported health was correlated to significantly lower odds of epistaxis.This study provides a comprehensive overview of the prevalence and risk factors of epistaxis outside the health care system. Our study suggests that preventive measures targeting these risk factors may reduce the incidence and severity of epistaxis in this population.
Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Lykkebaekvej 1, Køge, 4600, Denmark. lisette.hvid.hovgaard@gmail.com.
Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Lykkebaekvej 1, Køge, 4600, Denmark.Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Risk factors of epistaxis in rural Denmark: a cross-sectional population-based survey of data from the Lolland-Falster health study.

This study aims to examine the relationship between excessive daytime sleepiness (EDS) and attention impairment in Chinese individuals with obstructive sleep apnea (OSA).A total of 1996 OSA patients with an apnea-hypopnea index (AHI) of ≥ 5 events per hour were included in this study. EDS was measured using the Epworth Sleepiness Scale (ESS), while cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA).OSA patients with EDS demonstrated higher body mass index (BMI), comorbidities of hypertension and diabetes, decreased N3 sleep, increased AHI and ODI, as well as lower minimum oxygen saturation. Despite no significant differences in total cognitive scores assessed by MMSE and MoCA, individuals with comorbid sleepiness exhibited more evident attention deficits in the subdomains of MoCA. Stratified analysis indicated that regardless of age, educational level was the primary factor influencing attention in the AHI < =20 group. In the AHI > 20 group, attention impairment in patients younger than 40 remained significantly associated with education level, whereas for individuals aged 40 and above, attention deficits were associated with education level, age, and daytime sleepiness. The interaction analysis indicated that OSA severity modulated the impact of sleepiness on attention in patients aged 40 and above.A significant correlation was observed between EDS and attention deficits in Chinese individuals diagnosed with OSA, with a particular emphasis on patients aged 40 and above. The severity of OSA modulates the impact of sleepiness on attention in patients aged 40 and above.
Department of Respiratory and Critical Care Medicine, Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Department of Respiratory and Critical Care Medicine, Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.Department of Respiratory and Critical Care Medicine, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, China.
Department of Respiratory and Critical Care Medicine, Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.The Fifth People's Hospital of Wuxi City, Wuxi, China.
Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China.Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Department of Respiratory and Critical Care Medicine, Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China. chenruigood@126.com.Sleep Center, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China. chenruigood@126.com.
Impact of excessive daytime sleepiness on attention impairment in obstructive sleep apnea: a cross-sectional observational study.

Immune checkpoint inhibitor (ICI) monotherapy and chemotherapy (CT) have been used to treat recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC), with demonstrated survival benefits and good safety. However, whether combination therapy is superior to CT alone remains unclear. We summarized the existing evidence comparing the effectiveness and toxicities of ICI combined with CT versus CT alone.Online databases was conducted for eligible randomized controlled trials (RCTs) published up to November 1, 2023. Progression-free survival (PFS) and overall survival (OS) were the primary endpoint. Objective response rates (ORRs) and adverse events (AEs) were the secondary endpoint.Three randomized controlled trials (Capture-1st, JUPITER-02, and RATIONALE-309) were included. First-line ICI therapy combined with CT showed significant improvement in PFS (hazard ratio[HR], 0.53; 95% confidence interval[CI]: 0.44-0.64), OS (HR, 0.63;95%CI: 0.49-0.81) and ORRs (odds ratio[OR], 1.79;95%CI: 1.30-2.46), when compared with CT alone. AEs ≥ grade 3 during treatment and treatment-related deaths were not significantly different between the two groups.In patients with R/M-NPC, ICI therapy combined with CT showed improved ORRs, PFS, and OS, with similar safety as CT alone.
Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.Guangxi Tumor Radiation Therapy Clinical Medical Research Center, Nanning, 530021, Guangxi, China.Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, 530021, Guangxi, China.Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi, China.
Department of Oncology, The 923 Hospital of People's Liberation Army, Nanning, 530021, Guangxi, China.
Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China. kangmin@gxmu.edu.cn.Guangxi Tumor Radiation Therapy Clinical Medical Research Center, Nanning, 530021, Guangxi, China. kangmin@gxmu.edu.cn.Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, 530021, Guangxi, China. kangmin@gxmu.edu.cn.Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi, China. kangmin@gxmu.edu.cn.
Immune checkpoint inhibitor combined with chemotherapy versus chemotherapy alone in the first-line treatment for recurrent or metastatic nasopharyngeal carcinoma: a meta-analysis of random controlled trials.

Infants have digestive environments that are more favorable for microbial proliferation and subsequent endogenous nitrite production than those of adults, but direct evidence of this has been lacking. In this study, we propose a novel epidemiology of infant methemoglobinemia by demonstrating the risk posed by nitrite-producers in the gastrointestinal tract. Nitrite-producers from vegetables (n = 323) were exposed to stress factors of the gastrointestinal environment (gastric pH, intestinal bile salts, anaerobic atmosphere) reflecting 4 different postnatal age periods (Neonate, ≤1 month; Infant A, 1-3 months; Infant B, 3-6 months; Infant C, 6-12 months). High-risk strains with a nitrate-to-nitrite conversion rate of ≥1.3 %, the minimum rate corresponding to nitrite overproduction, under the Neonate stress condition were analyzed for intestinal adhesion. Among all the phyla, Pseudomonadota achieved the highest survival (P < 0.05; survival rate of 51.3-71.8 %). Possible cross-protection against bile resistance due to acid shock was observed for all the phyla. All the high-risk strains exhibited moderate autoaggregation (14.0-36.4 %), whereas only a few exhibited satisfactory surface hydrophobicity (>40 %). The Pantoea agglomerans strain strongly adhered to Caco-2 cells (7.4 ± 1.1 %). This study showed the ability of the Pantoea, Enterobacter, and Klebsiella strains to survive under gastrointestinal stress for ≤12 months, to excessively produce nitrite under neonatal stress conditions, and to settle in the human intestine. To our knowledge, this is the first study to reveal the role of the natural flora of vegetables in the epidemiology of infant methemoglobinemia through a multilateral approach.
Copyright © 2024 Elsevier Ltd. All rights reserved.
Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: rheems@korea.ac.kr.
Food research international (Ottawa, Ont.)
Novel hypothesis for infant methemoglobinemia: Survival and metabolism of nitrite-producers from vegetables under gastrointestinal stress and intestinal adhesion.

PANoptosis is considered a novel type of cell death that plays important roles in tumor progression. In this study, we applied machine learning algorithms to explore the relationships between PANoptosis-related lncRNAs (PRLs) and head and neck squamous cell carcinoma (HNSCC) and established a neural network model for prognostic prediction.Information about the HNSCC cohort was downloaded from the TCGA database, and the differentially expressed prognostic PRLs between tumor and normal samples were assessed in patients with different tumor subtypes via nonnegative matrix factorization (NMF) analysis. Subsequently, five kinds of machine-learning algorithms were used to select the core PRLs across the subtypes, and the interactive features were pooled into a neural network model to establish a PRL-related risk score (PLRS) system. Survival differences were compared via Kaplan‒Meier analysis, and the predictive effects were assessed with the areas under the ROCs. Moreover, functional enrichment analysis, immune infiltration, tumor mutation burden (TMB) and clinical therapeutic response were also conducted to further evaluate the novel predictive model.A total of 347 PRLs were identified, 225 of which were differentially expressed between tumor and normal samples. Patients were divided into two clusters via NMF analysis, in which cluster 1 had a better prognosis and more immune cells and functional infiltrates. With the application of five machine learning algorithms, we selected 13 interactive PRLs to construct the predictive model. The AUCs for the ROCs in the entire set were 0.735, 0.740 and 0.723, respectively. Patients in the low-PLRS group exhibited a better prognosis, greater immune cell enrichment, greater immune function activation, lower TMB and greater sensitivity to immunotherapy.In this study, we established a novel neural network prognostic model to predict survival and identify tumor subtypes in HNSCC patients. This novel assessment system is useful for prediction, providing ideas for clinical treatment.
Department of Otolaryngology Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China.
Department of Otolaryngology Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China. 798749265@qq.com.
Centre for Medical Research, Ningbo No.2 Hospital, Ningbo, China. tyzdhs@163.com.School of Medicine, Ningbo University, Ningbo, China. tyzdhs@163.com.
Integrative machine learning and neural networks for identifying PANoptosis-related lncRNA molecular subtypes and constructing a predictive model for head and neck squamous cell carcinoma.

Browning commonly appeared in apple processing, which varied in different apple varieties. Present work investigated the metabolomics of four varieties apple of Yataka, Gala, Sansa, and Fuji, which possessed different browning characteristics and related enzymes. Sansa as browning insensitive apple variety, exhibited the least chroma change with the lowest PPO activity and the highest SOD activity among the four apple varieties. Browning inhibition pretreatment increased the activity of SOD and PAL and decreased PPO and POD activity. In addition, metabolomic variances among the four apple varieties (FC), their browning pulp (BR) and browning inhibition pulp (CM) were compared. And the key metabolites were in-depth analyzed to match the relevant KEGG pathways and speculated metabolic networks. There were 487, 644, and 494 significant differential metabolites detected in FC, BR and CM, which were consisted of lipids, benzenoids, phenylpropanoids, organheterocyclic compounds, organic acids, nucleosides, accounting for 23 %, 11 %, 15 %, 16 %, 11 % of the total metabolites. The differential metabolites were matched with 39, 49, and 36 KEGG pathways in FC, BR, and CM, respectively, in which other secondary metabolites biosynthesis metabolism was the most significant in FC, lipid metabolism was the most significant in BR and CM, and energy metabolism was markedly annotated in CM. Notably, Sansa displayed the highest number of differential metabolites in both its BR (484) and CM (342). The BR of Sansa was characterized by flavonoid biosynthesis, while the other three apple varieties were associated with α-linolenic acid metabolism. Furthermore, in browning sensitive apple varieties, the flavonoid and phenylpropanoid biosynthesis pathway was significantly activated by browning inhibition pretreatment. Phenolic compounds, lipids, sugars, organic acids, nucleotides, and adenosine were regulated differently in the four apple varieties, potentially serving as key regulatory sites. Overall, this work provides novel insight for browning prevention in different apple varieties.
Institute of Food Science and Technology, CAAS, Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Beijing 100193, China.
Institute of Food Science and Technology, CAAS, Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Beijing 100193, China. Electronic address: bjfcaas@126.com.
Institute of Food Science and Technology, CAAS, Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Beijing 100193, China. Electronic address: lixuan19880305@live.cn.
Metabolomics comparison of four varieties apple with different browning characters in response to pretreatment during pulp processing.

Phytocannabinoids occurring in Cannabis Sativa L. are unique secondary metabolites possessing interesting pharmacological activities. In this study, the dynamics of thermally induced (60 and 120 °C) phytocannabinoid reactions in four cannabis varieties were investigated. Using UHPLC-HRMS/MS, 40 phytocannabinoids were involved in target analysis, and an additional 281 compounds with cannabinoid-like structures and 258 non-cannabinoid bioactive compounds were subjected to suspect screening. As expected, the key reaction was the decarboxylation of acidic phytocannabinoids. Nevertheless, the rate constants differed among cannabis varieties, documenting the matrix-dependence of this process. Besides neutral counterparts of acidic species, ́neẃ bioactive compounds such as hydroxyquinones were found in heated samples. In addition, changes in other bioactive compounds with both cannabinoid-like and non-cannabinoid structures were documented during cannabis heating at 120 °C. The data document the complexity of heat-induced processes and provide a further understanding of changes in bioactivities occurring under such conditions.
Copyright © 2024. Published by Elsevier Ltd.
Department of Food Analysis and Nutrition, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic.
Department of Food Analysis and Nutrition, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic. Electronic address: jana.hajslova@vscht.cz.
Thermally induced changes in the profiles of phytocannabinoids and other bioactive compounds in Cannabis sativa L. inflorescences.

To improve the color stability of anthocyanins (ACNs) in blueberry fermented beverage, the intermolecular copigmentation between ACNs and 3 different phenolic compounds, including (-)-epigallocatechin gallate (EGCG), ferulic acid (FA), and gallic acid (GA) as copigments, was compared in the model and the real blueberry fermented beverage, respectively. The copigmented ACNs by EGCG presented a high absorbance (0.34 a.u.) and redness (27.09 ± 0.17) in the model blueberry fermented beverage. The copigmentation by the participation of the 3 different phenolic compounds showed all a spontaneous exothermic reaction, and the Gibbs free energy (ΔG°) of the system was lowest (-5.90 kJ/mol) using EGCG as copigment. Furthermore, the molecular docking model verified that binary complexes formed between ACNs and copigments by hydrogen bonds and π-π stacking. There was a high absorbance (1.02 a.u.), percentage polymeric color (PC%, 68.3 %), and good color saturation (C*ab, 43.28) in the real blueberry fermented beverage aged for 90 days, and more malvidin-3-O-glucoside had been preserved in the wine using EGCG as copigment. This finding may guide future industrial production of blueberry fermented beverage with improved color.
Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization of Ministry of Agriculture and Rural Affairs, Anhui Engineering Laboratory for Agro-products Processing, Anhui Agricultural University, Hefei 230036, Anhui, China.
Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization of Ministry of Agriculture and Rural Affairs, Anhui Engineering Laboratory for Agro-products Processing, Anhui Agricultural University, Hefei 230036, Anhui, China. Electronic address: sharling@ahau.edu.cn.
Intermolecular copigmentation of anthocyanins with phenolic compounds improves color stability in the model and real blueberry fermented beverage.

To investigate the subjective effect of office-based blue laser therapy for inferior turbinate hypertrophy in patients with nasal obstruction.Patients with nasal obstruction who underwent office-based blue laser for the inferior turbinate hypertrophy between October 2022 and December 2023 were included in the study. The two outcome measures used to gauge the improvement in nasal obstruction and success of surgery were the Nasal Obstruction Symptom Evaluation (NOSE) scale and the Visual Analogue Scale (VAS). Patient's level of comfort during the procedure was also rated using a 10-point VAS scale.A total of 14 patients were included in this study. The mean age of the study group was 41.47 ± 18.52 and the F/M ratio was 4.67. All patients reported significant improvement in nasal breathing. The mean NOSE score decreased significantly from 13.07 ± 3.89 pre-operatively to 2.64 ± 2.43 post-operatively (p = 0.002). Similarly, the mean VAS score decreased from 7.43 ± 0.85 to 2.0 ± 1.57 (p = 0.002) following surgery. The procedure was well-tolerated by all participants and the mean total score ranged from 6 to 9 with an average of 7.59 ± 1.34.Office-based blue laser therapy for inferior turbinate hypertrophy may be an effective treatment modality for nasal obstruction from the patient's perspective. Although the procedures were tolerated well with no complications noted, these results should be cautiously interpreted until studies using objective measures are conducted.
Department of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Department of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon. ea27@aub.edu.lb.
Office-based blue laser therapy for inferior turbinate hypertrophy: a pilot study.

Literature has highlighted that the organic attribute has heuristic value for many consumers, representing an overarching signifier of positive characteristics. Nowadays a plethora of alternative systemic approaches side organic production in the aim to improve the overall sustainability of the agrifood sector. Current study, based on blind and informed tasting, measured sustainability information influence on respondents' (n = 162) perceptions of organic and fungus-resistant grape (FRG) white wines. Findings of the within-subject non hypothetical experiment revealed that information has a stronger, positive impact on participants' perception of organic wine (increasing 13 % monetary preferences) compared to FRG wine (+9%). Additionally, attitudinal characteristics driving consumers' preferences towards FRG wine diverge from organic core motivations.
Department of Agricultural Sciences, University of Naples Federico II, Italy.
Department of Agricultural Sciences, University of Naples Federico II, Italy. Electronic address: riccardo.vecchio@unina.it.
Research Center for the Viticulture and Oenology (CIRVE), University of Padova, Italy.
Department of Agronomy, Food, Natural Resources, Animals and Environment (DAFNAE), University of Padova, Italy.
Department of Land, Environment, Agriculture and Forestry, University of Padova, Italy.
Is wine perception influenced by sustainability information? Insights from a consumer experiment with fungus resistant grape and organic wines.

To explore utilization and efficacy of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in different sub-specialties of otolaryngology.A systematic search was performed using Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Medline, Clinicaltrials.gov, Scopus, and Google Scholar up to March 2024. English language randomized controlled trials with original data evaluating the use of PRP and PRF in various surgical and non-surgical procedures related to otolaryngologic sub-specialties. Dataset was limited to randomized controlled trials (RCTs) to have the best quality of evidence and possible recommendation.Our database search resulted in 591 manuscripts. Four hundred twenty-six studies were primarily excluded after reviewing the title and abstract. The remaining 165 articles were studied completely, and 51 articles met the inclusion criteria. All the studies were RCTs and dated from 2001 to 2024. They included 19 studies related to otology, 10 studies related to rhinology, 7 studies related to facial plastic surgery, 6 studies related to head and neck surgery, 3 studies related to general otolaryngology, 3 studies related to pediatrics, 2 studies related to laryngology, and 1 study related to sleep medicine.PRP and PRF are safe, easy to use, and potentially effective treatment options for multiple otolaryngology pathologies. As an autologous material, there is no risk of immune reaction, and thus has been selected as a viable treatment option by many otolaryngologists. Larger studies would be helpful to confirm efficacy and allow for optimized patient selection for this treatment option.
Department of Otolaryngology Head and Neck Surgery, Amir A'lam Hospital, Tehran University of Medical Sciences, Tehran, Iran.Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Stanford, CA, 94304, USA. zmpatel@stanford.edu.
Utilization and efficacy of platelet-rich plasma and platelet-rich fibrin in otolaryngology: a systematic evidence-based review.

The thermal treatment carried out in the processing of apple products is very likely to induce Maillard reaction to produce furfurals, which have raised toxicological concerns. This study aimed to elucidate the formation of furfural compounds in apple products treated with pasteurization and high pressure processing (HPP). The method for simultaneous determination of five furfural compounds including 5-hydroxymethyl-2-furfural (5-HMF), furfural (F), 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF), 2-acetylfuran (FMC), and 5-Methyl-2-furfural (MF) using high performance liquid chromatography equipped with diode array detector (HPLC-DAD) was successfully developed and validated. All five furfurals exhibited an increasing trend after the pasteurization treatment of apple clear juice, cloudy juice, and puree. 5-HMF, F, FMC, and MF were increased significantly during the precooking of apple puree. Whereas there was no significant change in the furfurals formation after apple products treated with high pressure processing (HPP) with 300 MPa and 15 min. Based on the variation of the fructose, glucose and sucrose detected in apple products after thermal treatment, it revealed that the saccharides and thermal treatment have great effect on the furfural compounds formation. The commercial fruit juice samples with different treatments and fruit puree samples treated with pasteurization were also analyzed. Five furfurals were detected more frequently in the fruit juice samples treated with pasteurization or ultra-high temperature instantaneous sterilization (UHT) than those treated with HPP. 5-HMF and FMC were detected in all fruit puree samples treated with pasteurization, followed by F, MF, and HDMF with the detection rate of 79.31 %, 72.41 %, and 51.72 %. The results could provide a reference for risk assessment of furfural compounds and dietary guidance of fruit products for human, especially for infants and young children. Moreover, moderate HPP treatment with 300 MPa and 15 min would be a worthwhile alternative processing technology in the fruit juice and puree production to reduce the formation of furfural compounds.
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Jiangsu Key Laboratory for Food Quality and Safety, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Science, Nanjing 210014, China.
Jiangsu Key Laboratory for Food Quality and Safety, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Science, Nanjing 210014, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Zhejiang Academy of Science and Technology for Inspection and Quarantine, Hangzhou 310016, China.
Jiangsu Key Laboratory for Food Quality and Safety, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Science, Nanjing 210014, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: lyjaas@163.com.
Jiangsu Key Laboratory for Food Quality and Safety, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Science, Nanjing 210014, China. Electronic address: zhangzhiyong@jaas.ac.cn.
Investigation of the formation of furfural compounds in apple products treated with pasteurization and high pressure processing.

Pain hyperacusis, also known as noxacusis, causes physical pain in response to everyday sounds that do not bother most people. How sound causes excruciating pain that can last for weeks or months in otherwise healthy individuals is not well understood, resulting in a lack of effective treatments. To address this gap, we identified the most salient physical and psychosocial consequences of debilitating sound-induced pain and reviewed the interventions that sufferers have sought for pain relief to gain insights into the underlying mechanisms of the condition. Adults (n = 32) with pain hyperacusis attended a virtual focus group to describe their sound-induced pain. They completed three surveys to identify common symptoms and themes that defined their condition and to describe their use of pharmaceutical and non-pharmaceutical therapies for pain relief. All participants endorsed negative effects of pain hyperacusis on psychosocial and physical function. Most reported sound-induced burning (80.77%), stabbing (76.92%), throbbing (73.08%), and pinching (53.85%) that occurs either in the ear or elsewhere in the body (i.e., referred pain). Participants reported using numerous pharmaceutical and non-pharmaceutical interventions to alleviate their pain with varying degrees of pain relief. Benzodiazepines and nerve blockers emerged as the most effective analgesic options while non-pharmaceutical therapies were largely ineffective. Symptoms of pain hyperacusis and therapeutic approaches are largely consistent with peripheral mechanistic theories of pain hyperacusis (e.g., trigeminal nerve involvement). An interdisciplinary approach to clinical studies and the development of animal models is needed to identify, validate, and treat the pathological mechanisms of pain hyperacusis.
Department of Speech, Language, and Hearing, The University of Texas at Dallas, Richardson, TX, USA.Callier Center for Communication Disorders, The University of Texas at Dallas, Dallas, TX, USA.
Department of Neuroscience and Center for Advanced Pain Studies, The University of Texas at Dallas, Richardson, TX, USA.
medRxiv : the preprint server for health sciences
Clinical phenotype and management of sound-induced pain: Insights from adults with pain hyperacusis.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
A case of solar urticaria with inhibition spectrum in ultraviolet radiation A and visible light successfully treated by ultraviolet radiation A rush hardening therapy.

Bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion after exhaustive evaluation of plasmatic coagulation and platelet function. This review explores the utility of global hemostatic assays as confirmatory tests and in elucidating the pathophysiology of BDUC. Unlike traditional hemostatic tests that focus on coagulation factors, global assays are conducted both in plasma and also whole blood. These assays provide a more comprehensive understanding of the cell-based model of coagulation, aid in the identification of plasmatic factor abnormalities that may reduce hemostatic capacity, and allow for the assessment of impaired platelet-endothelial interactions under shear stress, as well as hyperfibrinolytic states. While clinical tests such as skin bleeding time and global assays such as PFA-100 exhibit limited diagnostic capacity, the role of viscoelastic testing in identifying hemostatic dysfunction in patients with BDUC remains unclear. Thrombin generation assays have shown variable results in BDUC patients; some studies demonstrate differences compared with healthy controls or reference values, whereas others question its clinical utility. Fibrinolysis assessment in vitro remains challenging, with studies employing euglobulin clot lysis time, plasma clot lysis time, and fluorogenic plasmin generation yielding inconclusive or conflicting results. Notably, recent studies suggest that microfluidic analysis unveils shear-dependent platelet function defects in BDUC patients, undetected by conventional platelet function assays. Overall, global assays might be helpful for exploring underlying hemostatic impairments, when conventional hemostatic laboratory tests yield no results. However, due to limited data and/or discrepant results, further research is needed to evaluate the utility of global assays as screening tools.
Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Institute of Vascular Biology and Thrombosis Research, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Utility of Global Hemostatic Assays in Patients with Bleeding Disorders of Unknown Cause.

Benign laryngotracheal stenosis is widely managed with minimally invasive endoscopic interventions, such as laser incision or excision scar, and dilation. However, various endoscopic treatments are significantly associated with a high recurrence rate. Local auxiliary measures, including inhalation of steroids, injection of steroids, and local topical application of mitomycin C, have been studied in order to increase the success rate.To compare the efficacy of endoscopic treatments with and without local adjuncts in patients with benign laryngotracheal stenosis, and analyze their clinical outcomes, recurrence, and complications.In the meta-analysis, databases including PubMed, EMBASE, OVID, and Web of Science were searched for papers comparing the outcomes of adjunct therapy with non-adjunct therapy in patients with laryngotracheal stenosis. The duplicate publications, reviews, comments or letters, conference abstracts, and case reports were excluded. The random effect model was used for assessing the pooled risk estimates.Eight studies (1204 cases) referring to two prospective randomized controlled studies, two prospective cohort studies, and four retrospective cohort studies were ultimately included in the meta-analysis. Three delivery modes of adjuncts were identified, including intralesion steroid injection (n = 2), inhaled steroid (n = 2), and topical application of mitomycin C (n = 4). The decreased risk estimates of recurrence rate were detected in patients receiving endoscopic treatments with steroid injection or inhaled steroid, compared with endoscopic interventions alone (P < 0.05). Additionally, patients undergoing adjunct therapies had lower risk estimates of recurrence, compared to those receiving endoscopic procedures alone (P < 0.05), based on the subgroup of prospective cohort studies, subglottis, Mayer-Cotton scale of I-II degree, and stenosis length of < 3 cm. The high heterogeneity of the pooling risk estimates perhaps was due to factors of auxiliary drug, clinical characteristics of patients, and methodology. No discernible difference in the incidence of complication was identified.Local application of steroids to minimally invasive interventions appear to reduce the recurrence rate of laryngotracheal stenosis. Various adjuncts available, including steroids and mitomycin C, appear to be safe and associated with a low risk estimate of adjuncts-specific complication rate. High quality multi-center randomized controlled studies are needed, with sufficient periods for follow-up and subjective and objective outcome indicators, to properly evaluate the efficacy, safety, and cost-effectiveness of adjuvant drugs.
Department of Otolaryngology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. mw_mingwei@163.com.
Department of Otolaryngology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Local adjuncts to minimally invasive endoscopic interventions for benign laryngotracheal stenosis: a meta-analysis.

Complejo Asistencial Universitario de León, Dermatology Department, Spain. Electronic address: m.criadootero@gmail.com.
Complejo Asistencial Universitario de León, Dermatology Department, Spain.
Diagnosis of Pyemotes infestation: The comet sign.

This study aimed to assess reliable options for bedside diagnosis of silent aspiration in the intensive care unit by examining the use of default grayscale images (DGI) obtained using a mobile, general-purpose, radiography system capable of dynamic digital radiography (M-DDR) and inverted grayscale images (IGI) of DGI.This cohort study (exploratory and preliminary) involved 18 adult patients (mean age, 89.0 years) for whom a swallowing assessment request was received from their primary physicians. Fifty-six IGI videoclips were evaluated by three specialists using the penetration-aspiration scale (PAS), with the gold standard being the consensus reading of all three specialists. Another three speech-language pathologists (SLPs) assessed 56 DGI and IGI videoclips using the PAS. PAS scores 1 and 2 were classified as normal range, PAS scores 3-5 as pathological laryngeal penetration, and PAS scores 6-8 as aspiration. The correct rates with IGI and DGI were then determined, and the level of agreement of IGI and DGI evaluations was evaluated.The correct rate of all evaluators was 100% for normal range, 80-100% for pathological laryngeal penetration, and 83-100% for aspiration with IGI and 100% for normal range, 90% for pathological laryngeal penetration, and 83% for aspiration with DGI. The kappa coefficient for IGI and DGI showed almost complete agreement for abnormal conditions.Dynamic imaging of swallowing 2-5 ml of liquid using M-DDR performed for elderly patients at the bedside showed that aspiration assessments by SLPs obtained from DGI videos immediately after imaging are acceptable.
Department of Rehabilitation Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan. y-koyama@tokai.ac.jp.Department of Rehabilitation Medicine, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Hachioji, Tokyo, 192-0032, Japan. y-koyama@tokai.ac.jp.
Department of Radiologic Technology, Tokai University Hospital, Isehara, Kanagawa, Japan.
Department of Rehabilitation Technology, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.
Department of Rehabilitation Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Bedside diagnosis of silent aspiration using mobile dynamic digital radiography: a preliminary study.

Clinical registries have great potential for quality control of medical procedures regarding the indications, therapeutic processes and results, including their possible complications. This is particularly true when providing patients with severe hearing loss or deafness with a cochlear implant (CI). This treatment represents a lifelong care process that requires continuous quality control over time. On the initiative of the Executive Committee of the German Society of Otorhinolaryngology (Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., DGHNO-KHC), a national German CI registry (Deutsches Cochlear Implant Register, DCIR) was established in January 2022. This article focuses on the first demographic and baseline data of the DCIR.The DCIR covers the complete therapeutic process from indication, surgery, fitting and lifelong aftercare in CI therapy. By the end of 2022, 75 hospitals in Germany had agreed to contribute to the DCIR.During the year 2022, 63 hospitals actively contributed data to the DCIR. Pseudonymized data from 2,292 CI implantations (2,176 primary implantations, 99 explantations with immediate re-implantations and 17 re-implantations following an earlier explantation) in 2,108 patients were documented. Cochlear implantation was accomplished in 1,807 adults (≥ 18 years) and 301 children (< 18 years). Fourty patients (1,9%) were children < 1 year of age and 55 (2,6%) were patients > 85 years. From the total of 2,292 implantations, 226 (9.9%) were performed as simultaneous bilateral implantations (CI implantation in both ears of 113 patients on the same day of surgery) and 412 implantations (19.1% of 2,162 implantations with data provided on the contralateral ear's hearing status) were in patients with single sided deafness (normal hearing in the contralateral ear). In addition, the reported complications in 2022 were also evaluated. Seven reports (0.4%) of mild to moderate severe facial nerve dysfunctions were documented. No reports of severe or total facial nerve dysfunction (House-Brackmann grade V/VI), meningitis or death related to CI therapy were documented.Although still in the start-up phase, these initial DCIR data already provide an interesting first insight into the demographic structure and baseline data of CI therapy in Germany. The successful implementation of the DCIR represents an important step towards continuous quality control of CI care.
Department of Otorhinolaryngology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany. Stoever@med.uni-frankfurt.de.General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany. Stoever@med.uni-frankfurt.de.
Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle- Wittenberg, Halle (Saale), Germany.General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany.
Department of Otorhinolaryngology, Dresden University Hospital, Technical University, Dresden, Germany.
Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany.
Department of Otorhinolaryngology, Nordstadt Hospital, Hannover, Germany.General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany.
Department of Otorhinolaryngology, Freiburg University Hospital, Freiburg im Breisgau, Germany.
General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany.
Department of Otorhinolaryngology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
Department of Otorhinolaryngology, Essen University Hospital, Essen, Germany.General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany.
Department of Otorhinolaryngology, University Hospital (St. Elisabeth Hospital), Bochum, Germany.General Secretary, President or Past-President of the German Society for Otorhinolaryngology, Head and Neck Surgery e.V., Head Office, Bonn, Germany.
The German cochlear implant registry: one year experience and first results on demographic data.

This study is to define a subclassification system of jugular foramen paragangliomas (JFPs) and to demonstrate corresponding microsurgical outcomes of JFPs.Retrospective study.A single-center study.We conducted a retrospective review of the clinical data of 44 patients with JFPs who underwent surgical management. Extrabulbar(Be) tumor and intrabulbar(Bi) tumor are defined based on the growth patterns, receiver operating characteristic (ROC) curves of the imaging profile were generated and was confirmed based on intraoperative findings. Area Under Curve (AUC), accuracy, sensitivity, and specificity for diagnostic imaging were revealed. We also compared the correlation between the two growth patterns with Fisch's classification, blood loss, lower cranial nerves (LCNs) deficit.There are 27 (69%) cases of Bi tumor and 17 (39%) cases of Be tumor. Significant radiomics features between the two growth patterns were demonstrated, ROC curves achieved excellent AUCs for MRI sequences (T1W1 MRI, MR contrast-enhanced sequence, MR complex sequences and MR complex + DSA by 0.833, 0.833, 0.875, 0.944) and had statistically significant in diagnosis of two growth patterns (P<0.05). There was no statistical correlation between growth patterns of JFPs and intra-operative blood loss. Preoperative LCNs deficits and Fisch's classification of tumors were correlated with the growth patterns of JFPs (P < 0.05).We proposetd two growth patterns of JFPs in term of the inferior petrous sinus involvement. Identification of Bi or Be growth patterns preoperatively is helpful to design optimal surgical strategies and minimize postoperative complications.
Department of Otology and Skull Base Surgery, Eye Ear Nose &Throat Hospital, Fudan University, Shanghai, 200031, PR China.NHC Key Laboratory of Hearing Medicine, Fudan University), Shanghai, 200031, PR China.Research Center, Eye Ear Nose &Throat Hospital, Fudan University, Shanghai, 200031, PR China.Department of Otolaryngology, Chongqing General Hospital, Chongqing, PR China.
Department of Otology and Skull Base Surgery, Eye Ear Nose &Throat Hospital, Fudan University, Shanghai, 200031, PR China.NHC Key Laboratory of Hearing Medicine, Fudan University), Shanghai, 200031, PR China.Research Center, Eye Ear Nose &Throat Hospital, Fudan University, Shanghai, 200031, PR China.
Department of Otology and Skull Base Surgery, Eye Ear Nose &Throat Hospital, Fudan University, Shanghai, 200031, PR China. cfdai66@126.com.NHC Key Laboratory of Hearing Medicine, Fudan University), Shanghai, 200031, PR China. cfdai66@126.com.Research Center, Eye Ear Nose &Throat Hospital, Fudan University, Shanghai, 200031, PR China. cfdai66@126.com.
The intrabulbar or extrabulbar growth pattern and its surgical outcomes of jugular foramen paragangliomas.

Preservation of intracochlear structures and residual hearing has become a major concern in modern cochlear implant. Consequently, many efforts have been made to minimize intraoperative trauma, especially while cochlear fenestration and electrode insertion.Building on the core concept of soft surgery , a modified approach, described as diving technique for cochlear implant electrode array insertion is proposed. Steps and technical points are presented with figures, video and review of relevant anatomy.This novel diving technique is operationally feasible and safe, promising to minimize intraoperative invasion and thus preserve residual hearing in cochlear implant.
Department of Otorhinolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. zhangzhg@mail.sysu.edu.cn.Institute of Hearing and Speech, Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China. zhangzhg@mail.sysu.edu.cn.
Department of Otorhinolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.Institute of Hearing and Speech, Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China.
Diving technique of cochlear implant electrode insertion for hearing preservation: how I do it.

Department of Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, 110001, India.Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, 110001, India.
Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences (AIIMS), Sri Aurobindo Marg, New Delhi, 110029, India. drnitinchoudhary86@gmail.com.
Regarding: Is there a relationship between the severity of obstructive sleep apnea syndrome and the systemic immune inflammation index?

This study aimed to assess the efficacy and safety of ballon dilation of the eustachian tube (BDET) in adult population suffering from Eustachian tube dysfunction (ETD).Following PRISMA criteria, a systematic review was conducted by searching PubMed, Cochrane, and Embase databases from January 2015 to March 2024. The primary outcomes included Eustachian Tube Score (ETS), tympanometry, and Valsalva maneuver. The quality of studies was assessed using the Quality in Prognostic Studies (QUIPS) instrument.Overall, 11 studies were incorporated into the systematic review: two RCTs, three prospective investigations, and six retrospective studies. The balloon dilation in all investigations was performed using either Spiggle & Theis or Acclarent catheters for balloon dilation. There was heterogeneity across studies examining the effect of BDET on persistent ETD in terms of patient selection, period of follow-up, administration of conservative or surgical therapies, and use of assessment methods. Overall, the treatment yielded alleviation of symptoms, which either exhibited stability over time or demonstrated further improvement after an average duration of follow-up. Moreover, the incidence of complications was categorized as low and resolving spontaneously. The majority of the studies exhibited a high risk of bias related to confounding variables, and consequently, the overall risk of bias across most studies was considered high.The findings suggest BDET holds promise for ETD treatment, reducing symptom severity with minimal complications. Nonetheless, there is a need for improved studies that adhere to established indications, methodologies, and outcomes to establish a more robust body of evidence.
Department of Otorhinolaryngology, Head and Neck Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia. asdnjm@hotmail.com.
Department of Otorhinolaryngology, Head and Neck Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia.
Department of Otorhinolaryngology, Head and Neck Surgery, Taif University, Taif, Saudi Arabia.
Effect of balloon dilatation among adult population with eustachian tube dysfunction: a systematic review.

We report a case of a severe ear infection in a 35-year-old man treated with ixekizumab for psoriasis. Ixekizumab is a humanized monoclonal antibody that selectively prevents the interaction between interleukin 17 A and its receptor. Biologicals like ixekizumab are used to achieve symptom relief in autoimmune diseases including psoriasis. Unlike the mild upper respiratory tract infections usually described as side-effects of this treatment, we report a case of a patient who presented with a severe otitis media, complicated with a facial paresis and nasopharyngeal abscess. To the best of our knowledge, this is the first case presenting a severe, complicated ear infection as a possible side effect of ixekizumab. We conclude that when using ixekizumab, vigilance for upper airway infections is needed and if necessary, interruption of therapy should be considered. However, further research is needed to confirm this hypothesis.
Department of Otorhinolaryngology-Head and Neck Surgery, ENT Resident, University Hospitals Leuven, Leuven, 3000, Belgium. leonore.maertens@gmail.com.
Department of Otorhinolaryngology-Head and Neck Surgery, ENT Resident, University Hospitals Leuven, Leuven, 3000, Belgium.
Internal Medicine Department, University Hospitals Leuven, Leuven, 3000, Belgium.
Department of Otorhinolaryngology-Head and Neck Surgery, ENT Resident, University Hospitals Leuven, Leuven, 3000, Belgium.Department of Neurosciences, Research Group Experimental Oto-Rhino-Laryngology (ExpORL), KU Leuven, University of Leuven, Leuven, 3000, Belgium.
Severely complicated ear infection in a patient treated with ixekizumab: a case report.

This work was designed to assess the impact of varying zeolite concentrations in diet and litter to enhance broiler's growth performance, immunity, and litter quality. A complete random arrangement was used for distributing 525 unsexed Cobb 500 broiler chicks into seven treatments (75 chick / treatment), each treatment divided into 3 replicates (25 chicks / replicate). The 1st group (control one) received the recommended basal diet. Zeolite has been introduced to the basal diet (ZD) of the second, third, and fourth groups at concentrations of 5, 10, and 15 g/kg, respectively. The 5th, 6th and 7th groups used zeolite mixed with litter (ZL) at 0.5, 1, and 1.5 kg/m2 of litter, respectively. Due to the obtained results, adding zeolite with levels 15 g/kg of diet and 1.5 kg/1 m2 of litter, a significant improvement occurred in live body weight (LBW), body weight gain (BWG), feed intake (FI), feed conversion ratio (FCR) and European production efficiency factor (EPEF). Also, transaminase enzymes (ALT and AST), creatinine, white blood cells (WBCs) and different Immunoglobulins were significantly increased with different zeolite levels, except urea concentrations which showed reduced due to different zeolite treatments. In addition, spleen relative weight hasn't been affected by zeolite treatments, even though thymus and bursa relative weights had been affected significantly. Moreover, the antibodies' production to Newcastle disease virus (NDV) and Avian influenza virus (AIV) had increased significantly with adding zeolite with levels 10 g/kg of diet and 1.5 kg/1m2 of litter. Litter quality traits (NH3 concentration, pH values, and Moisture content) were improved with zeolite addition. So, zeolite could be employed in both feed and litter of broilers to maximize their production, immunity and improve farm's climate.
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Animal Production Research Institute, Agricultural Research Center, Dokki, Giza 12618, Egypt.
Animal Production Research Institute, Agricultural Research Center, Dokki, Giza 12618, Egypt; Laboratory of Gastrointestinal Microbiology, National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, China.
Animal Production Department, Faculty of Agriculture, Benha University, Egypt.
Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Department of Biology, College of Science, Imam Mohammed Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.
Department of Biology, College of Science, Imam Mohammed Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia; Department of Zoology, Faculty of Science, Beni-Suef University, Beni-suef, 65211 Egypt. Electronic address: allam@imamu.edu.sa.
Department of Biology, College of Science, King Khalid University, Abha 61413, Saudi Arabia.
Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Impact of adding zeolite to broilers' diet and litter on growth, blood parameters, immunity, and ammonia emission.

The study aimed to identify parameters that could predict oncological and functional outcomes in patients with pT4aN0 laryngeal squamous cell carcinoma (LSCC) who underwent open partial horizontal laryngectomy (OPHL). The role of paratracheal neck dissection (PTND) was analyzed as the primary outcome. Additionally, the study compared the outcomes of patients who underwent postoperative radio/chemotherapy (PORT/PORCT) with those who refused or did not adhere to adjuvant treatments.Twenty-nine OPHL patients whose pathological exam was consistent with pT4aN0-x disease were enrolled and their clinical charts were retrospectively reviewed. The study analyzed oncological outcomes, such as local, regional, and distant recurrence rates (RR), overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS). Additionally, functional results were analyzed, including decannulation rate, hospitalization time, and postoperative complication rate.The study revealed and overall recurrence rate of 27%. The final rates for OS and DSS were 68% and 79%, respectively. Based on the univariate analysis the PTND was significantly associated with longer DFS. No significant differences inoncological outcomes were observed between pT4a patients who underwent adjuvant radio/radiochemotherapy and those who did not, in terms of RR, DFS, DSS or OS. However, adjuvant treatment was found to significantly increase decannulation time.In a properly super-selected subgroup of patients with pT4aN0 LSCC, OPHL may beconsidered as a conservative surgical option even without adjuvant treatment. However, for optimal oncological outcomes, it is strongly recommended to consider a central compartment dissection in cases of hypoglottic and anterior extra-laryngeal tumor extension.
Otolaryngology Unit, Vittorio Veneto Hospital, via Forlanini 71, Vittorio Veneto, Treviso, Italy.
Otolaryngology Unit, Head-Neck Surgery Section, Neuroscience Department, Padova University, Padova, Italy.
Phoniatrics and Audiology Section, Neuroscience Department, Padova University, Padova, Italy.
Medical Direction Unit, Vittorio Veneto Hospital, Treviso, Italy.
Otorhinolaryngology Unit, San Giovanni Bosco Hospital, Turin, 10154, Italy.
Otolaryngology Unit, Vittorio Veneto Hospital, via Forlanini 71, Vittorio Veneto, Treviso, Italy. marco.lionello@aulss2.veneto.it.
The role of central neck dissection and adjuvant treatment in pT4aN0 laryngeal carcinoma treated with open partial horizontal laryngectomy.

Suppurative perichondritis of the auricle is a common disease that can easily cause malformations if it develops into an uncontrolled infection. In nearly half of the cases, otolaryngologists cannot identify the pathogens involved.In the present work, we described two cases of pyogenic perichondritis, with negative on conventional culture. However, using metagenomic next-generation sequencing (mNGS), we detected fungal infections in the patients and after the patients were given anti-fungal treatment, the patients achieved a good prognosis.These cases highlighted the possibility that fungi might be the involved pathogens in patients who have had multiple negative bacterial cultures, and mNGS should be applied in these cases. mNGS could be used as a supplement to traditional culture methods.
Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, 300192, China.Institute of Otolaryngology of Tianjin, Tianjin, China.Key Laboratory of Auditory Speech and Balance Medicine, Tianjin, China.Key Medical Discipline of Tianjin (Otolaryngology), Tianjin, China.Quality Control Centre of Otolaryngology, Tianjin, China.
Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, 300192, China. cyan6398@sina.com.Institute of Otolaryngology of Tianjin, Tianjin, China. cyan6398@sina.com.Key Laboratory of Auditory Speech and Balance Medicine, Tianjin, China. cyan6398@sina.com.Key Medical Discipline of Tianjin (Otolaryngology), Tianjin, China. cyan6398@sina.com.Quality Control Centre of Otolaryngology, Tianjin, China. cyan6398@sina.com.
Perichondritis of the auricle: bacterial or fungal? (A case series).

Antibiotics have been prescribed routinely in sialendoscopy procedures to reduce the risk of postoperative infection, despite the limited evidence supporting this practice. Being necessary to assess the need for antibiotics in Sialendoscopy, aiming to provide evidence-based guidance to clinicians regarding antibiotic administration in this procedure.A prospective, randomized, double-blind, controlled clinical trial to evaluate the of prophylactic antibiotics in Sialendoscopy was designed.A total of 80 patients were included in this study, including 57 females (71.8%) and 23 males (28.8%). In terms of prophylaxis, 36 patients (45%) received prophylactic treatment, and 44 patients (55%) did not. The occurrence of infectious events was observed in 2 patients (5.6%) with prophylaxis and 4 patients (9.1%) without prophylaxis. However, this difference was not statistically significant (p = 0.556).In conclusion, our prospective, randomized clinical trial aimed to address the debate regarding the use of prophylactic antibiotics in sialendoscopy. Our study's findings suggest that the routine use antibiotics may not be necessary to prevent postoperative infections in sialendoscopy procedures. These results have important implications for clinical practice, potentially reducing the unnecessary use of antibiotics and addressing concerns related to antibiotic resistance and adverse drug reactions.
Department of Otorhinolaryngology, Osakidetza Donostia University Hospital, Biodonostia Research Institute, San Sebastian, 20014, Spain. chiesaestomba86@gmail.com.Otorhinolaryngology Department, Faculty of Medicine, Deusto University, Bizkaia, Spain. chiesaestomba86@gmail.com.Head & Neck Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France. chiesaestomba86@gmail.com.
ENT and Cervicofacial Surgery Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.Otorhinolaryngology Department, Faculty of Medicine, Universidad Alfonso X el Sabio, Madrid, Spain.
Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Forlì, 47121, Italy.Head & Neck Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
Department of Otolaryngology and Head and Neck Surgery, Division of Laryngology and Broncho-Esophagology, UMONS Research Institute for Health Sciences and Technology, EpiCURA Hospital, University of Mons, Mons, Belgium.Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Otorhinolaryngology - Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coruña (CHUAC), Galicia, 15006, A Coruña, Spain.Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.Head & Neck Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
Department of Otorhinolaryngology, Osakidetza Donostia University Hospital, Biodonostia Research Institute, San Sebastian, 20014, Spain.
Prophylactic antibiotics in sialendoscopy: a randomized clinical trial.

Interventional Cardiology Department, Cardiovascular Institute, Institut d'Investigacions Biomèdiques August Pi I Sunyer, CIBER-CV, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address: masabate@clinic.cat.
Editorial: Complete revascularization in acute coronary syndrome: The older the better.

Department of Medical Sciences, Faculty of Medicine of Albacete, University of Castilla-La Mancha, Albacete, Spain; Centre for Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain. Electronic address: Jesus.Gonzalez@uclm.es.
Department of Medical Sciences, Faculty of Medicine of Albacete, University of Castilla-La Mancha, Albacete, Spain; Centre for Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete, Spain.
Comments on «Is the sustainability of exposure to non-ionizing electromagnetic radiation possible?».

The current investigation aimed to establish preliminary normative data for endoscopic swallow studies (FEES). The investigators collected data for three timing measures (time to whiteout, duration of whiteout, and total swallow time), three swallowing outcomes (safety, efficiency, and number of swallows per bolus), and one physiologic event (glottal response), for both healthy young and older adults using two liquid volumes, one pureed bolus and a solid bolus.Blinded raters retrospectively analyzed 65 randomly selected, deidentified videos of endoscopic swallowing examinations from a pool of 163 young and older adults with typical swallowing abilities. Timing measures and analysis of airway invasion, amount of residue, number of swallows, and glottal response were obtained.Preliminary means and quartiles were established for healthy adults in two age groups (young and old), for time to whiteout (WO), number of swallows per bolus, glottal response, Yale Residue Rating Scale Scores, Penetration-Aspiration Scale scores, duration of WO, and total swallow duration. Differences were found between the older and younger groups.The current study represents a preliminary attempt to provide quantitative and normative values for FEES. These data represent reference values to which other bolus presentations and populations can be compared. The data represents proof of concept and merits additional investigation.1756246-2: Approved 2022/06/06.Study does not meet criteria. DATA REPOSITORY: https://doi.org/10.6084/m9.figshare.25800025 .
BS University of Nevada, Reno School of Medicine, North Virginia Street, MS 0152, Reno, NV, 89557, USA.
Reno School of Medicine, Department of Public Health, University of Nevada, Reno, NV, USA.
MS, Moravian University College of Health School of Rehabilitative Science, Moravian, PA, USA.
IOPI Medical, LLC, Clinical consulting, Woodinville, WA, USA.
University of Nevada, Reno School of Medicine, Speech Pathology and Audiology, Reno, NV , USA. kgalek@med.unr.edu.
Normal values for swallow events during endoscopic evaluation of swallowing: a preliminary study.

Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood.We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics samples were collected from 52 well-characterized participants before, during, and three months after a nine-day inquiry-based stress reduction program.We found that depression was associated with both an increased presence of putatively pathogenic bacteria and reduced microbial beta-diversity. Following the intervention, we observed reductions in neuroinflammatory cytokines and improvements in several mental health indicators. Interestingly, participants with a Prevotella-dominant microbiome showed milder symptoms when depressed, along with a more resilient microbiome and more favorable inflammatory cytokine profile, including reduced levels of CXCL-1.Our findings reveal a protective link between the Prevotella-dominant microbiome and depression, associated with a less inflammatory environment and moderated symptoms. These insights, coupled with observed improvements in neuroinflammatory markers and mental health from the intervention, highlight potential avenues for microbiome-targeted therapies in depression management.
Department of Genetics, Stanford University School of Medicine, CA, USA.Stanford Center for Genomics and Personalized Medicine, Stanford university School of Medicine, CA, USA.These authors contributed equally to the work.
Department of Genetics, Stanford University School of Medicine, CA, USA.Stanford Healthcare Innovation Lab, Stanford University, CA, USA.These authors contributed equally to the work.
Department of Genetics, Stanford University School of Medicine, CA, USA.
Department of Genetics, Stanford University School of Medicine, CA, USA.Department of Microbiology, College of Arts and Sciences, University of Washington, WA, USA.
Department of Genetics, Stanford University School of Medicine, CA, USA.Stanford Healthcare Innovation Lab, Stanford University, CA, USA.
West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China.
Oxford Centre for Microbiome Studies, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
The Ohio State University Comprehensive Cancer Center, OH, USA.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Department of Genetics, Stanford University School of Medicine, CA, USA.Stanford Center for Genomics and Personalized Medicine, Stanford university School of Medicine, CA, USA.Stanford Healthcare Innovation Lab, Stanford University, CA, USA.
bioRxiv : the preprint server for biology
Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program.

There are few options for treatment of dysphonia secondary to vocal pathology related to lamina propria scar, atrophy, sulcus, or inflammatory disorders. Platelet rich plasma (PRP) may provide anti-inflammatory and regenerative properties seen with other tissue engineering therapies without the risks associated with these treatments. We evaluated vocal fold (VF) injection of PRP for feasibility, phonatory effects, patient satisfaction and durability.Patients with dysphonia secondary to vocal fold scar, atrophy, sulcus and inflammatory lesions were included. PRP injections were administered in office, to bilateral vocal folds. Patients were followed up at 1 week, 1 month, 3 months and 6 months to assess outcomes (GRBAS scale, maximum phonation time, vocal fatigue index (VFI), voice handicap index (VHI-10) and stroboscopy).75 intracordal PRP injections were administered to 48 patients. All injections were completed, and no adverse reactions were experienced. Improvements in VHI-10 scores at 1,3,6 months were seen (mean VHI 21.73 at baseline, 15.62 at six months, p < 0.001). 72.3% rated improvement at 7 or above on Likert scale. 95.7% of patients would consider a future PRP injection. Secondary outcomes VFI, MPT, and GRBAS also demonstrated significant improvements over time. Patients receiving a single PRP injection (n = 26) still demonstrated significant VHI-10 improvements at 1,3 and 6 months.VF office PRP injections are feasible and safe and can provide phonatory benefit and reduce vocal effort in benign VF disorders. A single PRP injection is sufficient to provide sustained benefit in some cases.Level III: prospective cohort study.
Department of Surgery, University of Auckland, Private Bag 91019, Grafton Auckland, New Zealand.
Department of Surgery, University of Auckland, Private Bag 91019, Grafton Auckland, New Zealand. jeallen@voiceandswallow.co.nz.
Platelet Rich plasma injection of the vocal folds in benign vocal pathologies.

Identifying outcome measurements instruments (OMIs) to evaluate treatment efficacy in patients with vocal fold atrophy and/or sulcus.Systematic review of records published before March 2021 by searching Pubmed and EMBASE. Included studies reported on adults (> 18 year) with dysphonia caused by glottic insufficiency due to vocal fold atrophy with or without sulcus, who were enrolled into a randomized controlled trial, a non-randomized controlled trial, a case-controlled study or a cohort study. All included studies described an intervention with at least one outcome measurement.A total of 5456 studies were identified. After removing duplicates, screening title and abstract and full text screening of selected records, 34 publications were included in final analysis. From these 50 separate OMIs were recorded and categorized according to the ELS protocol by DeJonckere et al. (Eur Arch Otorhinolaryngol 258: 77-82, 2001). With most OMIs being used in multiple studies the total number of OMIs reported was 265. Nineteen (19) individual OMIs accounted for 80% of reports. The most frequently used OMIs according to category were: VHI and VHI-10 (subjective evaluation); G of GRBAS (perceptual evaluation); F0, Jitter and Shimmer (acoustic evaluation); MPT and MFR (aerodynamic evaluation) and glottic closure and mucosal wave (endoscopic evaluation). Of these OMIs VHI had a high percentage of significance of 90%.This systematic review identifies the most used OMIs in patients with glottic incompetency due to vocal fold atrophy and/or sulcus as a step toward defining a Core Outcome Set (COS) for this population.238274.
Department of Otorhinolaryngology/Head and Neck Surgery, Leiden University Medical Center, Albinusdreef 2, PO-Box 9600, 2300 RC, Leiden, The Netherlands. E.M.J.M.van_den_Broek@lumc.nl.Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center, Utrecht, The Netherlands. E.M.J.M.van_den_Broek@lumc.nl.
Department of Otorhinolaryngology/Head and Neck Surgery, Leiden University Medical Center, Albinusdreef 2, PO-Box 9600, 2300 RC, Leiden, The Netherlands.
Glottic insufficiency caused by vocal fold atrophy with or without sulcus: systematic review of outcome measurements.

It is well known that the digastric posterior belly is one of the essential landmarks for facial nerve identification during parotid surgery. While there were multiple reports about variations of the digastric anterior belly, only a few anatomical variations of the posterior belly of the digastric muscle have been described.In this article, we describe an anatomical variation of the posterior belly of digastric muscle found during superficial parotidectomy of a patient with pleomorphic adenoma. This anatomical variation also led to an anatomical variation in the position of the facial nerve.To our knowledge, this is the first report of an absent posterior belly of digastric muscle found during live parotid surgery. The knowledge of current anatomical variation may help to avoid facial nerve injury during parotid surgery and preserve the function of muscles of facial expression.
Department of Head & Neck Surgery, Unit - 1, Christian Medical College, Paul Brand Building, Vellore, 632004, India.
Department of Head & Neck Surgery, Unit - 1, Christian Medical College, Paul Brand Building, Vellore, 632004, India. jjriju@yahoo.co.in.
Navigating the void: outcomes and adaptations during parotid surgery in the absence of posterior belly of digastric muscle.

Division of Cardiovascular Medicine, New York University Health System, New York, NY, USA. Electronic address: sunil.rao@nyulangone.org.
Department of Internal Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Editorial: The need for standardized feedback systems for interventional cardiologists.

Sinonasal mucoceles (SM) are benign, expansive neoformations which require surgical marsupialization to prevent severe complications. The present study reports the larger case history ever published: a 28-years expertise in the surgical management of SM.A retrospective study was conducted on patients surgically treated for SM at the Departments of Otorhinolaryngology of Varese and Pavia, between 1994 and 2022.398 patients were reported. An endoscopic endonasal marsupialization of SM was performed in 92,5% of cases. 7% of patients underwent a combined approach while 0,5% required an exclusive open surgery. The average follow-up after surgery was 10-60 months. SM overall recurrence was observed in 11,4% of cases.Endonasal endoscopic SM marsupialization is a feasible technique which allows the preservation of the anatomy and physiology avoiding the surgical invasiveness of the external approaches. The well-established surgical expertise in the endonasal endoscopy together with technological improvements widened the indication range of the exclusive endoscopic technique over the traditional open surgery.
Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, Ospedale di Circolo e Fondazione Macchi, University of Insubria-Varese, ASST Sette Laghi, Varese, Italy. chiara.zeroli@gmail.com.
Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, Ospedale di Circolo e Fondazione Macchi, University of Insubria-Varese, ASST Sette Laghi, Varese, Italy.
Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, Ospedale di Circolo e Fondazione Macchi, University of Insubria-Varese, ASST Sette Laghi, Varese, Italy.Head and Neck Surgery and Forensic Dissection Research Center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
A 28 years surgical experience of 398 sinusal mucoceles: how technologies, techniques and experiences have changed their treatment throughout the years.

Department of Cardiology, University of Mississippi Medical Center, Jackson, MS, United States of America.
Editorial: Mechanical circulatory support in acute myocardial infarction with cardiogenic shock: A friend or a foe?

Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd, Taipei City, 10449, Taiwan.
Department of Otolaryngology-Head and Neck Surgery, Communication Enhancement Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd, Taipei City, 10449, Taiwan.Department of Audiology and Speech Language Pathology, Mackay Medical College, New Taipei, Guan-Min Ho, Taiwan.
Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd, Taipei City, 10449, Taiwan. Floydgm@gmail.com.Yomin ENT and Pediatric Clinic, Taipei, Taiwan. Floydgm@gmail.com.APrevent® Medical, Taipei, Taiwan. Floydgm@gmail.com.
Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd, Taipei City, 10449, Taiwan. lichunhsieh1978@gmail.com.Department of Audiology and Speech Language Pathology, Mackay Medical College, New Taipei, Guan-Min Ho, Taiwan. lichunhsieh1978@gmail.com.Department of Medicine, Mackay Medical College, New Taipei, Taiwan. lichunhsieh1978@gmail.com.
Eur Arch Otorhinolaryngol. 2024-10;281(10):5569.
Correction: Long-term voice outcomes of medialization thyroplasty with adjustable implant for unilateral vocal fold paralysis.

The overall survival of laryngeal squamous cell carcinoma (LSCC) hasn't changed significantly in the last decades, leading to a negative prognosis in advanced stages. So, the immunotherapy takes space with the inhibition of PD-1/PD-L1 checkpoint, involved in suppression of immune response.A prospective study was conducted on LSCC patients, selected according to strict criteria. The study was approved by the ethics committee of our Hospital. Parameters were: sex, age, smoking and alcohol habits, C-reactive protein (CRP) level in the serum, laryngeal subsite involved, differentiation-based histopathologic grading of tumor, neck node involvement, tumor stage, expression levels of PD-L1 (as Combined Positive Score - CPS). P-value < 0.05 was statistically significant.58 patients were included: 31.03% were females, mean age 63.55±10.09. A statistically significant correlation between CPS and smoking habits and N stage was found. CRP resulted increased in 44.83% of patients with a statistically significant correlation with CPS. The most cases were glottic cancers (46.55%). 75.86% of tumors were moderately-differentiated, without correlation with CPS.PD-L1 expression levels are variables independent of sex, age, alcohol consumption, differentiation degree of LSCC. A statistically significant correlation between PD-L1 expression levels and smoking habits, neck node status and CRP was found. This last finding demonstrates the involvement of PD-1/PD-L1 checkpoint in immune response in case of cancer. However, these results need further studies to detect the best patients tailored for treatment with anti-PD-1/PD-L1 blocking antibodies.
Unit of Otorhinolaryngology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, Palermo, Italy. barbara.verro@unipa.it.
Unit of Otorhinolaryngology, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, Palermo, Italy.
Unit of Anesthesia, Intensive Care, and Emergency, Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy.
Cancer and immune response: The role of PD-1/PD-L1 checkpoint in laryngeal carcinoma. Preliminary results.

Skin cancer specimen handling in Australian histopathology laboratories, while largely standardised, exhibits significant variations that affect clinical decision-making and patient outcomes.This article provides clinicians with an understanding of histopathological processes to enhance diagnostic precision, inform surgical margin evaluations and refine management approaches.Understanding specimen handling and protocols is vital for accurate interpretation of pathology reports and management of skin cancers. Variations in sampling, examination and sectioning can affect pathological diagnosis and margin assessment. Clinician insights into laboratory processes are crucial for best practice. Retention of specimens and reports allows for further evaluation if clinical circumstances evolve or additional investigations are required.
MBChB, FRCPA, Dermatopathologist, Douglass Hanly Moir Pathology @ Macquarie Park, Sydney, NSW; Senior Lecturer, Faculty of Medicine, The University of Queensland, Brisbane, Qld; Visiting Professor, Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
BComm, Phlebotomist, Douglass Hanly Moir Pathology @ Macquarie Park, Sydney, NSW.
MBBS, FRCPA, Dermatopathologist, Douglass Hanly Moir Pathology @ Macquarie Park, Sydney, NSW.
Skin cancer: What happens in the laboratory?

Drug administration errors (DAEs) in anaesthesia are common, the aetiology multifactorial and though mostly inconsequential, some lead to substantial harm. The extend of DAEs remain poorly quantified and effective implementation of prevention strategies sparse.A cross-sectional descriptive study was conducted using a peer-reviewed survey questionnaire, circulated to 2217 anaesthetists via a national communication platform. The aim was to determine the self-reported frequency, nature, contributing factors and reporting patterns of DAEs among anaesthesia providers in South Africa.Our cohort had a response rate was 18.9%, with 420 individuals populating the questionnaire. 92.5% of surveyed participants have made a DAE and 89.2% a near-miss. Incorrect route of administration, potentially resulting in serious harm, accounted for 8.2% (n = 23/N = 279) of these errors. DAEs mostly reported in cases involving adult patients (80.5%, n = 243/N = 302), receiving a general anaesthetic (71.8%, n = 216/N = 301), where the drug-administrator prepared the drugs themselves (78.7%, n = 218/N = 277), during normal daytime hours (69.9%, n = 202/N = 289) with good lightning conditions (93.0%, n = 265/N = 285). 26% (n = 80/N = 305) of DAEs involved ampoule misidentification, whilst syringe identification error reported in 51.6% (n = 150/N = 291) of cases. DAEs are often not reported (40.3%, n = 114/N = 283), with knowledge of correct reporting procedures lacking. 70.5% (n = 198/N = 281) of DAEs were never discussed with the patient.DAEs in anaesthesia remain prevalent. Known error traps continue to drive these incidents. Implementation of system based preventative strategies are paramount to guard against human error. Efforts should be made to encourage scrupulous reporting and training of anaesthesia providers, with the aim of rendering them proficient and resilient to handle these events.
Department Anaesthesiology and Critical Care, University of Stellenbosch, Parow, Cape Town, 7500, South Africa. rene.potg@gmail.com.
Department Anaesthesiology and Critical Care, University of Stellenbosch, Parow, Cape Town, 7500, South Africa.
Drug administration errors among anaesthesia providers in South Africa: a cross-sectional descriptive study.

Área del Corazón, Hospital Universitario Virgen de la Victoria, CIBERCV, IBIMA Plataforma BIONAND, Departamento de Medicina UMA, Centro de Investigación Biomédica en Red de Enfermedades, Spain; Interventional Cardiology Unit, BIOMORF Department, University of Messina, Italy.
Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Keele, UK.
Editorial: Does troponin I overestimate periprocedural myocardial infarction more than troponin T in PCI patients? The devil is in the details.

Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Cardiology Department, SS. Annunziata Hospital, ASL 2 Abruzzo, Chieti, Italy.
Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy; Cardiology Department, SS. Annunziata Hospital, ASL 2 Abruzzo, Chieti, Italy. Electronic address: m.zimarino@unich.it.
Editorial: Prosthesis-patient mismatch prediction in TAVR valve-in-valve procedures.

To analyze the skin injuries of hospitalized newborns and identify factors related to the number of lesions.This was a cross-sectional epidemiological study carried out over a period of one year in a Neonatal Intensive Care Unit in the west of Paraná. The study included 74 newborns with a score ≥5 on the Newborn Skin Condition Scale. Data analysis by chi-square and Pearson's test (p < 0.05).The frequency was 25.4%, 59.4% had more than one lesion, mainly dermatitis and pressure injury. Birth characteristics were not related to the number of lesions. Not using antibiotics and parenteral nutrition, hemoglobin >11g/dl, phototherapy, pain score <4 and hospitalization >30 days were related to the number of lesions. The presence of two injuries led to longer healing time and three to longer hospitalization. A higher score on the Skin Condition Scale was related to healing time and late start of the diet.Skin injuries were found to be infrequent among newborns, but there is still a need to improve practices to prevent and maintain skin integrity.
Hospital Universitário do Oeste do Paraná, Programa de Residência Multiprofissional em Neonatologia. Cascavel, PR, Brazil.
Universidade Estadual do Oeste do Paraná, Centro de Educação, Letras e Saúde, Foz do Iguaçu, PR, Brazil.
Universidade Estadual do Oeste do Paraná, Centro de Educação, Letras e Saúde, Programa de Residência Multiprofissional em Neonatologia, Cascavel, PR, Brazil.
Revista da Escola de Enfermagem da U S P
Skin injuries in newborns hospitalized in neonatal intensive care: a cross-sectional study.

Cardiovascular disease (CVD) is one of the leading causes of death in women, largely underpinned by hypertension. Current guidelines recommend first-line therapy with a RAAS-blocking agent especially in young people. There are well documented sex disparities in CVD outcomes and management. We evaluate the management of patients with newly diagnosed hypertension in a tertiary care clinic to assess male-female differences in investigation and treatment.Clinic letters of all new patients under the age of 51 attending the Glasgow Blood Pressure Clinic between January and December 2023 were reviewed. The primary outcomes measured were first-line treatment choices, deviations from guideline-recommended treatment, investigations for secondary hypertension, and documentation of female-specific risk factors and family planning advice. Secondary outcomes included clinical characteristics such as systolic and diastolic blood pressure at referral and at the new patient appointment, age at diagnosis, age at first appointment, and the number of antihypertensive drugs prescribed at referral.One hundred and five (59:46, M:F) new patient encounters were reviewed after sixteen exclusions for non-attendance and inappropriate clinic coding. Choice of first line antihypertensive agent did not vary between sexes with no deviation from guideline-recommended medical therapy. Men, however, had more biochemical investigations conducted for secondary causes across all ages. This was greatest in those under 40 years old. There was suboptimal documentation of female-specific risk factors (obstetric and gynaecological history), contraceptive drug history and family planning with 35%, 20%, and 15.6%, respectively.In 2023, women under 51 years of age seen in a tertiary care hypertension clinic received similar first-line treatment to their male peers. However, relevant female-specific histories were suboptimally documented for these patients. Whilst therapeutic approaches in men and women appear to be similar in this clinic, there are opportunities to improve CVD prevention in women, even in a specialised clinic setting.
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Queen Elizabeth University Hospital, Glasgow, UK.
Hypertension, or persistent high blood pressure, is a condition that can lead to serious cardiovascular diseases such as stroke and heart failure. Evidence has shown that women have cardiovascular disease more than men and it is the leading cause of death in women in Europe. To understand how male and female patients are treated for hypertension, we examined documented consultations and treatments of 105 patients under the age of 51 (46 women and 59 men) at a Glasgow hypertension clinic in 2023. We found that men had more investigations for specific causes of their hypertension across all ages (men = 88%, women = 61%). Recording of reproductive history (35%), contraceptive drug history (20%) and advice on family planning (15.6%) was not as thorough as they could be. Incorrect management of female reproductive history and contraceptive drug history can increase the risk of long-term hypertension complications, so managing this is crucial. A class of drugs commonly used to manage hypertension called RAAS blockers are dangerous to the foetus when pregnant - another factor to consider when managing young women with high blood pressure. Overall, these findings mean that there may be a need for more thorough consideration of women’s health factors in hypertension treatment. By paying attention to these areas, we can enhance long-term cardiovascular health for women.
Hypertension evaluation and management in new young patients: are we doing our female patients a disservice?

China has the third largest number of TB cases in the world, and the average annual floating population in China is more than 200 million, the increasing floating population across regions has a tremendous potential for spreading infectious diseases, however, the role of increasing massive floating population in tuberculosis transmission is yet unclear in China.29,667 tuberculosis flow data were derived from the new smear-positive pulmonary tuberculosis cases in China. Spatial variation of TB transmission was measured by geodetector q-statistic and spatial interaction model was used to model the tuberculosis flow and the regional socioeconomic factors.Tuberculosis transmission flow presented spatial heterogeneity. The Pearl River Delta in southern China and the Yangtze River Delta along China's east coast presented as the largest destination and concentration areas of tuberculosis inflows. Socioeconomic factors were determinants of tuberculosis flow. Some impact factors showed different spatial associations with tuberculosis transmission flow. A 10% increase in per capita GDP was associated with 10.2% in 2010 or 2.1% in 2012 decrease in tuberculosis outflows from the provinces of origin, and 1.2% in 2010 or 0.5% increase in tuberculosis inflows to the destinations and 18.9% increase in intraprovincial flow in 2012. Per capita net income of rural households and per capita disposable income of urban households were positively associated with tuberculosis flows. A 10% increase in per capita net income corresponded to 14.0% in 2010 or 3.6% in 2012 increase in outflows from the origin, 44.2% in 2010 or 12.8% increase in inflows to the destinations and 47.9% increase in intraprovincial flows in 2012. Tuberculosis incidence had positive impacts on tuberculosis flows. A 10% increase in the number of tuberculosis cases corresponded to 2.2% in 2010 or 1.1% in 2012 increase in tuberculosis inflows to the destinations, 5.2% in 2010 or 2.0% in 2012 increase in outflows from the origins, 11.5% in 2010 or 2.2% in 2012 increase in intraprovincial flows.Tuberculosis flows had clear spatial stratified heterogeneity and spatial autocorrelation, regional socio-economic characteristics had diverse and statistically significant effects on tuberculosis flows in the origin and destination, and income factor played an important role among the determinants.
College of Geography and Environmental Science, Henan University, KaiFeng, 475001, China.Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions, Henan University, Ministry of Education, KaiFeng, 475001, China.
State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Science and Natural Resource Research, Chinese Academy of Sciences, Beijing, 100101, China.
State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Science and Natural Resource Research, Chinese Academy of Sciences, Beijing, 100101, China. wangjf@lreis.ac.cn.
College of Geography and Environmental Science, Henan University, KaiFeng, 475001, China. jjqiao@henu.edu.cn.Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions, Henan University, Ministry of Education, KaiFeng, 475001, China. jjqiao@henu.edu.cn.
Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
College of Geography and Environmental Science, Henan University, KaiFeng, 475001, China.
Modeling tuberculosis transmission flow in China, 2010-2012.

Evaluating the impact of radioiodine therapy (RIT) on olfactory function in thyroid cancer patients through quantitative and qualitative olfactory tests.In this cohort study, patients with thyroid cancer were included. Demographic, clinical, and laboratory data were collected. To subjectively evaluate the olfactory changes aftter RIT, the Visual Analog Scale (VAS), Self-Reported Mini-Olfactory Questionnaire (self-MOQ), and the University of Washington Quality of Life Questionnaire (UW-QOL) were assessed. Out of UW-QOL questions those related to saliva, taste, and overall health condition were analysed. For objective assessment, patients underwent both the Butanol Threshold Test (BTT) and the a version of Smell Identification Test (SIT). Patients were assessed before, one month, and six months after RIT.Ninety eight patients were included (Male = 17). A statistically significant decrement was observed in olfaction based on the VAS, between the baseline and one (pvalue = 0.015) and six months (pvalue = 0.031) of follow-up. Additionally, saliva (pvalue = 0.001), taste (pvalue = 0.000), and overall health condition (pvalue = 0.010) significantly decreased one-month after RIT. The measures were not different between the baseline and 6-month follow up and the improvement of index of taste was significant from 1-month to 6-months follow ups (pvalue = 0.000). However, none of the objective tests (the BTT and the SIT) indicated a significant decline in olfaction during the follow up.A subjective RIT related decrease in smell function, taste, and saliva production was documented without any objective olfactory dysfunction.
Otorhinolaryngology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. meabbasi@sina.tums.ac.ir.
Subjective and objective effects of radioiodine therapy on the sense of smell.

Bone anchored hearing implants (BAHI) are considered for conductive and mixed hearing loss, relying on osseointegration of a titanium implant. Limitations relate to constant skin contact, with resultant percutaneous infections and granulation. This study investigates whether patient characteristics and implant-specifications contribute to BAHIs' skin complications in a cohort with a uniform surgical approach.A 10 year (2014-2024) retrospective cohort study was conducted on BAHI procedures that were undertaken using a tissue-preserving 'punch' technique. Data on patient demographics, co-morbidities, implant type, surgical approach, and complications were collected. Poisson regression analysis was used to identify predictors of complications.A total of 53 patients undergoing 55 BAHI surgeries by three ENT consultants were included. Factors that greatly increased implant-related percutaneous infections included the Cochlear™ BIA400 implant when compared to the Ponto™ BHX implant (twofold, CI 2.03-2.16), abutment sizes ≤ 10 mm (fourfold, CI 3.99-4.12) and male gender (9%, CI 1.07-1.12). Granulation episodes were affected by cardiovascular disease (CVD) status (1.5-fold, CI 0.26-0.78), BIA400 implant (threefold, CI 8.8.-9.2) and abutment sizes ≤ 10 mm (fourfold, CI 3.6-3.73). Revision surgery episodes increased with diabetic status (1.2-fold, CI 0.06-0.37) and abutment sizes ≤ 10 mm (threefold, 3.303-3.304).Larger cohort studies are required to confirm findings, particularly for implant and abutment size contributions. However, the findings suggest that using a larger abutment size when skin thickness meassuremets are borderline, improved hygiene education in male patients, pre-operative optimisation of CVD and diabetes, and adjusted patient follow-up based on risk stratification of the contributing factors to complication rates could reduce complication rates.
ENT Department, Leighton Hospital, Middlewich Road, Crewe, UK.
ENT Department, Leighton Hospital, Middlewich Road, Crewe, UK.ENT Department, Ain Shams University, Cairo, Egypt.
ENT Department, Leighton Hospital, Middlewich Road, Crewe, UK. Bernhard.Attlmayr@mcht.nhs.uk.
Beyond the surface: exploring contributing factors to bone anchored hearing implant complications.

Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China.
Department of Cardiology, Peking University First Hospital, Beijing, China.
Successful treatment with spesolimab for generalized pustular psoriasis in an elderly patient with TRPM4 mutation.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
A case of siliconoma in the penis in which microanalysis was useful for diagnosis.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Possible effectiveness of switching biologics from adalimumab to certolizumab pegol in pyoderma gangrenosum.

Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou Institute of Dermatology and Venereology, Zhejiang, Hangzhou, China.
Regarding retrospective study of the clinical significance of the neutrophil-to-lymphocyte ratio in 79 patients with palmoplantar pustulosis .

Surgical Director, Heart Transplantation and Mechanical Circulatory Support, Department of Cardiac Surgery, Piedmont Heart Institute, 95 Collier Rd NW Suite 3000, Atlanta, GA 30309, United States of America. Electronic address: Ezequiel.Molina@piedmont.org.
Editorial: Improving outcomes with standardized care in high-risk patients supported with a percutaneous microaxial flow pump.

Cardiovascular center OLV, Aalst, Belgium; Department of Cardiology, Toulouse university Hospital, Toulouse, France.
Hospital Clinico Universitario San Carlos IDSCC, Complutense University of Madrid, Madrid, Spain.
Cardiovascular center OLV, Aalst, Belgium.
Cardiovascular center OLV, Aalst, Belgium. Electronic address: carloscollet@gmail.com.
Microcirculatory status after intravascular lithotripsy: The MARVEL study.

Correction: Management of Petrous Bone Cholesteatoma: The Gruppo Otologico Experience.

This pilot study aimed to determine whether the Henkin olfactory test discriminates between the olfactory function of patients with olfactory loss and healthy individuals, and whether the Henkin test is correlated with a validated psychophysical olfactory test.Participants underwent olfactory testing using the modified Henkin test (including detection [DT] and recognition [RT] thresholds, magnitude estimation [ME], and hedonic ratings [H], for four different odors) and the extended Sniffin' Sticks test battery (odor detection, discrimination, identification).Forty-four individuals (28 women, aged 19-81 years, mean: 39 years) were included. Twenty-three were healthy (mean age: 38 years) and 21 had olfactory dysfunction (OD) (mean age: 40 years). OD patients had worse mean DT, lower composite RT, and lower ME ratings. Mean and individual odor H ratings were not significantly different between the groups. Most individuals were classified as hyposmic when using the prescribed classification by Henkin, with only very few satisfying the stringent criteria of anosmia and normosmia. Modified Henkin subtests were all positively correlated with each other and with the Sniffin' Sticks , except for Unpleasant Mean H which was only correlated with Pleasant Mean H; and Pleasant mean H which was not correlated with mean DT scores.The Henkin test is able to separate between OD patients and controls. However, modifications to the conduct of this test may be required. Studies that used this test should be carefully interpreted.
Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. akmhernandezmd@gmail.com.Department of Otolaryngology - Head and Neck Surgery, Asian Hospital and Medical Center, Muntinlupa, Philippines. akmhernandezmd@gmail.com.
Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
The olfactory test established by Henkin: is it reliable and does it correlate to established psychophysical tests?

Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.
Author reply to regarding retrospective study of the clinical significance of the neutrophil-to-lymphocyte ratio in 79 patients with palmoplantar pustulosis .

University of Florida, Department of Internal Medicine, United States of America.
University of Florida, Division of Cardiovascular Medicine, United States of America. Electronic address: David.anderson@medicine.ufl.edu.
Editorial: Response to Outcomes in transcatheter aortic valve replacement (TAVR) patients requiring red blood cell transfusion: A nationwide perspective .

Patients with p16 positive tonsillar cancer (p16 + TC) have an excellent prognosis and long-life expectancy. Deintensification of therapy is a prevalent topic of discussion. Proton radiotherapy is one way to reduce radiation exposure and thus reduce acute and late toxicity. The aim is to evaluate treatment outcomes and toxicity of postoperative treatment with intensity-modulated proton therapy (IMPT).Between September 2013 and November 2021, 47 patients with p16 + TC were treated postoperatively with IMPT. Median age was 54.9 (38.2-74.9) years, 31 were males and 16 were females. All patients had squamous cell carcinoma and underwent surgery as a primary treatment. Median dose of radiotherapy was 66 GyE in 33 fractions. Bilateral neck irradiation was used in 39 patients and unilateral in 8. Concomitant chemotherapy was applied in 24 patients.Median follow-up time was 4.2 (0.15-9.64) years. Five-year overall survival, relapse free survival and local control were 95.7%, 97.8% and 100%. The most common acute toxicities were dermatitis and mucositis, with grade 2 + in 61.7% and 70.2% of patients. No acute percutaneous gastrostomy insertion was necessary and intravenous rehydration was used in 12.8% of patients. The most common late toxicity was grade 1 xerostomia in 70.2% of patients and grade 2 in 10.6% of patients. Subcutaneous fibrosis of grades 2 and 3 occurred in 17.0% and 2.1% of patients, respectively. One patient developed late severe dysphagia and became PEG-dependent.IMPT for the postoperative treatment of p16 + TC is feasible with excellent efficiency and acceptable acute and late toxicity.
Proton Therapy Center Czech, Budínova 1a, Prague 8, 18000, Czech Republic.Department of Health Care Disciplines and Population Protection, Faculty of Biomedical Engineering, Czech Technical University Prague, Sítná square 3105, Kladno, 272 01, Czech Republic.
Proton Therapy Center Czech, Budínova 1a, Prague 8, 18000, Czech Republic.
Proton Therapy Center Czech, Budínova 1a, Prague 8, 18000, Czech Republic. michal.andrlik@ptc.cz.
Proton pencil beam scanning radiotherapy in the postoperative treatment of p16 positive squamous cell tonsillar cancer - evaluation of toxicity and effectivity.

Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico G. Rodolico - San Marco , University of Catania, Catania, Italy.
Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico G. Rodolico - San Marco , University of Catania, Catania, Italy. Electronic address: dcapodanno@unict.it.
Editorial: C-reactive protein and TAVR: Impact of inflammation on patient outcomes.

Department of Dermatology, Faculty of Medicine, Kindai University Hospital, Osaka, Japan.
A case of eczematous paradoxical reactions on the extremities during tildrakizumab treatment for plaque psoriasis.

School of Population and Global Health, McGill University, Montreal, QC H3A 1G1, Canada; Manipal Academy of Higher Education, Manipal, India. Electronic address: madhukar.pai@mcgill.ca.
Washington University School of Medicine, Saint Louis, MO, USA.
School of Population and Global Health, McGill University, Montreal, QC H3A 1G1, Canada.
Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland.
Tackling antimicrobial resistance: recognising the proposed five blind spots can accelerate progress.

Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Department of Dermatology, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Dermatology Hospital, Southern Medical University, Guangzhou, China.
Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen, Guangdong, China.
Coexistence of Basan syndrome and cutaneous basal cell carcinoma: Genetic and clinical perspectives.

Department of Dermatology, Teikyo University Chiba Medical Center, Chiba, Japan.
Department of Plastic and Reconstructive Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
Department of Pathology, Teikyo University Chiba Medical Center, Chiba, Japan.
HPV 51-associated inguinal SCC on an atopic dermatitis patient treated with cyclosporine.

Department of Dermatology, University Hospital Basel, Basel, Switzerland.Department of Dermatology, Dermatopathology Training Center, University Hospital Basel, Basel, Switzerland.Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Department of Dermatology, University Hospital Basel, Basel, Switzerland.
Department of Dermatology, Philipps-University of Marburg, Marburg, Germany.
Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.
Nevus comedonicus with lesional growth of terminal hair: An unusual case.

Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Department of Nephrology, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Grade 3 acute kidney injury caused anti-glomerular basement membrane nephritis during immune checkpoint inhibitor treatment for melanoma.

Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL.
Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL. Electronic address: rdhawan@bsd.uchicago.edu.
University of Texas Southwestern Medical Center and Children's Medical Center in Dallas, Dallas, TX.
Department of Surgery, Section of Cardiac and Thoracic Surgery, The University of Chicago, IL.
Journal of cardiothoracic and vascular anesthesia
J Cardiothorac Vasc Anesth. 2025-02;39(2):538-545.
Stepwise Mechanical Circulatory Support in a Pediatric Patient With Respiratory Failure Facilitating Mobilization and Recovery.

Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan.
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kochi, Japan.
Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Kochi, Japan.
A case of IgA vasculitis with Koebner phenomenon of the nose.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Department of Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
A case of solitary encapsulated angiolymphoid hyperplasia with eosinophilia in the hypodermis of possible lymph node origin.

Department of Dermatology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.
Upadacitinib shows efficacy in Netherton syndrome with poor response to Dupilumab.

Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan.
A case of Stevens-Johnson syndrome after influenza a virus infection.

School of Medicine, University College Dublin, Dublin, Ireland; Department of Cardiology, Mater Misericordiae University Hospital, Dublin, Ireland. Electronic address: andrew.sharp@ucd.ie.
Bellevue Hospital Center, NYU Langone Health, NYU Grossman School of Medicine, New York, NY, USA.
Editorial: Improving outcomes in High Risk PE - a glimpse of the future?

Quality Administration, Henry Ford Health, Detroit, MI.
Department of Urology, Henry Ford Health, Detroit, MI. Electronic address: bhussai1@hfhs.org.
Department of Urology, Henry Ford Health, Detroit, MI.
Letter to the Editor: Use of Catheterization Algorithms to Manage Acute Urinary Retention; What is the Evidence?

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil.
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil; Hospital de Guarnição de Natal, Rio Grande do Norte, Brazil.
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil; Antimicrobial Resistance Institute of São Paulo (ARIES), São Paulo, Brazil.
One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil.
Hospital de Guarnição de Natal, Rio Grande do Norte, Brazil.
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil; Antimicrobial Resistance Institute of São Paulo (ARIES), São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil. Electronic address: lincopan@usp.br.
Global epidemiological trend of Klebsiella pneumoniae ST340: emergence of subclade KL15 co-producing K pneumoniae carbapenemase-2 and New Delhi metallo-β-lactamase-7 in the Americas.

HCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London NW9 5HT, UK. Electronic address: akan.otu@ukhsa.gov.uk.
HCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London NW9 5HT, UK.
Data for action: the crucial role of hospitals in controlling Clostridioides difficile infection in England.

Department of Dermatology, Faculty of Medicine and Medical Sciences, Saint Georges Hospital University Medical Center, University of Balamand, Beirut, Lebanon.
Department of Family Medicine, Faculty of Medicine and Medical Sciences, Saint Georges Hospital University Medical Center, University of Balamand, Beirut, Lebanon.
A challenging case of pityriasis versicolor with clinical resistance to Itraconazole.

Gene therapy with Adeno-Associated Viral (AAV) vectors requires knowledge of their tropism within the body. Here we analyze the tropism of ten naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAVrh8, AAVrh10 and AAVrh74) following systemic delivery into male and female mice. A transgene expressing ZsGreen and Cre recombinase was used to identify transduction in a cell-dependent manner based on fluorescence. Cre-driven activation of tdTomato fluorescence offered superior sensitivity for transduced cells. All serotypes except AAV3B and AAV4 had high liver tropism. Fluorescence activation revealed transduction of unexpected tissues, including adrenals, testes and ovaries. Rare transduced cells within tissues were also readily visualized. Biodistribution of AAV genomes correlated with fluorescence, except in immune tissues. AAV4 was found to have a pan-endothelial tropism while also targeting pancreatic beta cells. This public resource enables selection of the best AAV serotypes for basic science and preclinical applications in mice.
A Comprehensive Atlas of AAV Tropism in the Mouse.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Bimekizumab-induced acral pustulovesicular eruption in a patient with psoriatic arthritis.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Successful treatment of nail psoriasis by switching to a TYK2 inhibitor after cyclosporine.

Department of Dermatology, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
Department of Dermatology, Tokyo Medical and Dental University Hospital, Tokyo, Japan.Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Simultaneous skin infection of Mycobacterium chelonae and Nocardia thailandica.

Department of Respiratory Medicine, General University Hospital Gregorio Marañon, Faculty of Medicine, Complutense University of Madrid, Gregorio Marañon Health Research Institute (IiSGM), Madrid, Spain. Electronic address: stephbrionesa@gmail.com.
Department of Respiratory Medicine, General University Hospital Gregorio Marañon, Faculty of Medicine, Complutense University of Madrid, Gregorio Marañon Health Research Institute (IiSGM), Madrid, Spain.

Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Department of Advanced Endoscopy, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
A case of familial Mediterranean fever complicated by IgA vasculitis and psoriasis vulgaris.

Department of Urology, Vanderbilt University Medical Center, Nashville, TN. Electronic address: Nicholas.l.kavoussi@vumc.org.
Editorial Comment on Application of AI-MR in the Planning of PCNL for Special Types of Complex Upper Urinary Stones: A Pilot Study .

We used cross-sectional data from 226 patients with monkeypox virus to investigate the association between anatomic exposure site and lesion development. Penile, anorectal, and oral exposures predicted lesion presence at correlating anatomic sites. Exposure site also predicted the first lesion site of the penis and anus.
Analysis of Monkeypox Virus Exposures and Lesions by Anatomic Site.

The impact of nephrolithiasis on skeletal growth and bone health across the life span of kidney stone formers is reviewed.Bone disease is an early event among kidney stone formers (SF), with distinct phenotypes according to each age, sex, menopausal status, dietary, hormonal and genetic factors. Nephrolithiasis-associated bone disorder is characterized by reduced bone mineral density (BMD) and histologically discloses low bone formation, high bone resorption and abnormal mineralization. Although hypercalciuria has been presumed to be pathogenic for bone loss in SF, the association of BMD with urinary calcium is not uniform in all studies. Hypocitraturia, metabolic disturbances, cytokines and receptors, growth factors and acid-base status may all influence skeletal outcomes. The potential link of bone disease with vascular calcification and cardiovascular disease among SF is discussed. The unique vulnerability of the younger skeleton to the effects of nephrolithiasis on attainment of peak bone mass and strength is highlighted and the association of bone loss with kidney stone formation early in life indicate the opportunity for intervention to reduce the risk of future bone fractures.
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, Rua Botucatu 740 - Vila Clementino, São Paulo, 04023-900, Brazil. ita.heilberg@gmail.com.
Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, Rua Botucatu 740 - Vila Clementino, São Paulo, 04023-900, Brazil.
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.Division of Pediatric Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Between a Rock and a Short Place-The Impact of Nephrolithiasis on Skeletal Growth and Development Across the Lifespan.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Efforts have been focused on developing new anti-HCC agents and understanding their pharmacology. However, few agents have been able to effectively combat tumor growth and invasiveness due to the rapid progression of HCC. In this study, we discovered that fangchinoline (FAN), a bisbenzylisoquinoline alkaloid derived from Stephania tetrandra S. Moore, effectively inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells. FAN treatment also led to the suppression of IL6 and IL1β release, as well as the expression of inflammation-related proteins such as COX-2 and iNOS, and the activation of the NF-κB pathway, thereby reducing inflammation-related EMT. Additionally, FAN directly bound to forkhead box protein M1 (FOXM1), resulting in decreased levels of FOXM1 proteins and disruption of the FOXM1-ADAM17 axis. Our in vivo findings confirmed that FAN effectively hindered the growth and lung metastasis of HCCLM3-xenograft tumors. Importantly, the upregulation of FOXM1 in HCC tissue suggested that targeting FOXM1 inhibition with FAN or its inhibitors could be a promising therapeutic approach for HCC. Overall, this study elucidated the anti-tumor effects and potential pharmacological mechanisms of FAN, and proposed that targeting FOXM1 inhibition may be an effective therapeutic strategy for HCC with potential clinical applications.
Copyright © 2024 Elsevier Inc. All rights reserved.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Shenzhen University General Hospital-Lishui Hospital Joint Research Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China.
Clinic of General Surgery, Molecular Oncology and Immunotherapy, Rostock University Medical Center, Rostock 18059, Germany.
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt.
Shenzhen University General Hospital-Lishui Hospital Joint Research Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Shenzhen University General Hospital-Lishui Hospital Joint Research Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China. Electronic address: minjiangchenv@163.com.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Shenzhen University General Hospital-Lishui Hospital Joint Research Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China. Electronic address: Zhaozw79@163.com.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Shenzhen University General Hospital-Lishui Hospital Joint Research Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China. Electronic address: jijiansong@zju.edu.cn.
Fangchinoline inhibits metastasis and reduces inflammation-induced epithelial-mesenchymal transition by targeting the FOXM1-ADAM17 axis in hepatocellular carcinoma.

The mycotoxin-producing fungi contamination of foodstuffs and agricultural commodities is a serious problem. In this study, the efficacy of acetic acid (AcA), chitosan (CS), and CS with extra AcA (CS/extra AcA) against Aspergillus flavus (A. flavus) in vitro and in vivo were investigated. Results showed that CS/extra AcA strongly inhibited the mycelial growth and aflatoxins production of A. flavus at lower concentrations than CS (MIC > 16.0 mg/mL) or AcA (MIC: 0.31 %). Significant inhibition was achieved in the presence of 4.0/0.12 and 8.0/0.08 CS (mg/mL)/extra AcA (%). CS/extra AcA exhibited remarkable antifungal activities based on the results of spore germination inhibition, abnormalities of spore morphology, disruption of cell membrane, mitochondrial dysfunction, and induction of apoptosis of hyphae. Moreover, pathogenicity test in peanut kernels showed that 8.0/0.16 CS (mg/mL)/extra AcA (%) could effectively inhibit the fungal infection and aflatoxin B1 production. The efficacy of CS/extra AcA is possibly due to the synergy of the antifungal property of CS, and undissociated AcA. The findings referred that CS/extra AcA is safe, efficient, and economical, and it could be used as a promising way to control A. flavus contamination in agro-foods preservation.
Copyright © 2024 Elsevier B.V. All rights reserved.
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China. Electronic address: huangjy@zjgsu.edu.cn.
School of Public Health, Jining Medical University, Jining 272067, PR China; School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, PR China.
Synergistic effect of acetic acid and chitosan against Aspergillus flavus.

Programmed cell death (PCD) pathways play pivotal roles in the development and progression of peripheral nerve injury (PNI). PANoptosis, as a novel form of PCD pathway with key features of pyroptosis, apoptosis and necroptosis, is implicated in the pathogenesis of multiple neurologic diseases. This study aimed to identify PANoptosis-related biomarkers and characterize their molecular roles and immune landscape in PNI. PANoptosis-related genes (PRGs) were retrieved from Reactome pathway database and previous literatures. Differentially expressed PANoptosis-related genes (DEPRGs) were identified based on a time-series transcriptome sequencing dataset. DEPRGs were predicted to be enriched in inflammatory response, inflammatory complex, PCD and NOD-like receptor signaling pathway through GO, KEGG, Reactome and GSEA analysis. Hub genes, including Ripk3, Pycard and Il18, were then recognized through PPI network and multiple algorithms. The molecular regulatory mechanisms of hub genes were elucidated by transcription factor network and competing endogenous RNA network. Moreover, the immune cell landscape of hub genes was analyzed. Eventually, the expression levels of hub genes were verified through external dataset and animal model. Ripk3, Pycard and Il18 were remarkably upregulated in PNI samples, which were in consistent with the results of bioinformatic analysis. This study uncovered the molecular characterization of PANoptosis-related genes in PNI and illustrated the novel PANoptosis biomarkers for PNI.
Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China.
Department of Orthopedics, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 210000, China. Electronic address: 541197081@sjtu.edu.cn.
Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Orthopedics, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China. Electronic address: lvfeizhou@huashan.org.cn.
Molecular characterization of PANoptosis-related genes as novel signatures for peripheral nerve injury based on time-series transcriptome sequencing.

Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España. Electronic address: antoniobustosmerlo@gmail.com.
Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España.
Hereditary salt-wasting tubulopathy associated with SLC12A3 mutation: Description of a case of Gitelman Syndrome.

Current blood coagulation models consider the interactions between blood, the vessel wall, and other tissues that expose tissue factor (TF), the main initiator of coagulation. A potential role of body fluids other than blood is generally not considered. In this review, we summarize the evidence that body fluids such as mother's milk saliva, urine, semen, and amniotic fluid trigger coagulation. The ability of these body fluids to trigger coagulation is explained by the presence of extracellular vesicles (EVs). These EVs expose extrinsic tenase complexes (i.e., complexes of TF and activated factor VII) that can trigger coagulation. Why these body fluids share this activity, however, is unknown. Possible explanations are that these body fluids contribute to hemostatic protection and/or to the regulation of the epithelial barrier function. Further investigations may help understand the underlying cellular and biochemical pathways regulating or contributing to coagulation and innate immunity, which may be directly relevant to medical conditions such as gastrointestinal bleeding and chronic inflammatory bowel disease.
Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, The Netherlands.Amsterdam Vesicle Center, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, The Netherlands.
Investigations on the Hemostatic Potential of Physiological Body Fluids.

We aimed to investigate the risk of hip fracture associated with zoledronic acid treatment compared to alendronate on a population level. The risk of hip fracture was lower in women using zoledronic acid and higher in women who had discontinued treatment. The findings support the effectiveness of intravenous bisphosphonate.To investigate whether zoledronic acid (ZOL) was associated with a lower risk of the first hip fracture than alendronate (ALN) in Norway using real-world data.Nationwide data on drugs dispensed in outpatient pharmacies were individually linked with all hospital-treated hip fractures. Individuals aged 50-89 years without previous hip fracture were included at their first filling of a prescription for ALN or ZOL during 2005-2016. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) for first hip fracture by time-varying exposure to ZOL versus ALN were estimated in sex-stratified flexible parametric survival analyses. Covariates included time-varying accumulated ALN exposure and comorbidity level expressed by the prescription-based Rx-Risk Comorbidity Index, marital status, education, and residential urbanity.Of 75,250 women who initiated treatment, 72,614 (96.5%) were exposed to ALN and 6366 (8.5%) to ZOL. Of 12,739 men who initiated treatment, 12,311 (96.6%) were exposed to ALN and 784 (6.2%) to ZOL. In women, the HR for first hip fracture was 0.75 (95% CI: 0.61-0.91) for ZOL versus ALN. In men, the corresponding HR was 0.59 (95% CI: 0.32-1.07). Discontinued treatment was associated with increased risk compared with current ALN treatment in women (HR: 1.33; 95% CI: 1.24-1.42, men: HR 1.13 (95% CI: 0.95-1.35)).In women, the risk of first hip fracture when treated with ZOL was 25% lower than when treated with ALN. Discontinued treatment was associated with a 33% increase in hip fracture risk. Similar, albeit statistically non-significant, results were observed in men.
Norwegian Research Centre for Women's Health, Oslo University Hospital, Oslo, Norway. solvor.riska@gmail.com.Department of Physical Health and Ageing, Norwegian Institute of Public Health, Oslo, Norway. solvor.riska@gmail.com.Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway. solvor.riska@gmail.com.
Norwegian Research Centre for Women's Health, Oslo University Hospital, Oslo, Norway.
Department of Endocrinology, Innlandet Hospital Trust, Hamar, Norway.Department of Endocrinology, Oslo University Hospital, Oslo, Norway.
Department of Physical Health and Ageing, Norwegian Institute of Public Health, Oslo, Norway.Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway.
Department of Neuromedicine and Movement Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.Department of Rheumatology, St. Olavs Hospital, Trondheim, Norway.
Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway.
Department of Physical Health and Ageing, Norwegian Institute of Public Health, Oslo, Norway.
Risk of first hip fracture under treatment with zoledronic acid versus alendronate: a NOREPOS cohort study of 88,000 Norwegian men and women in outpatient care.

Hospital Universitario San Agustín, Avilés, Asturias, España. Electronic address: bcarrascoaguilera@gmail.com.
Hospital Universitario San Agustín, Avilés, Asturias, España.
Pyoderma gangrenosum following inguinal hernioplasty.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.
The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: nsingla2@jhmi.edu.
Editorial Comment on Virtual Reality as an Adjunct to Traditional Patient Counseling in Patients With Newly-Diagnosed Localized Prostate Cancer .

Servicio de Radiología, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: abelgonzalezhuete@gmail.com.
Servicio de Radiología, Hospital Universitario Ramón y Cajal, Madrid, España.
Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, España.
Metastatic pulmonary calcification: Another great imitator.

Distinguished Career Emeritus Professor of Physical Therapy, Orthopaedic Surgery and Rheumatology, Virginia Commonwealth University, Richmond, VA 23298-0224, USA. Electronic address: dlriddle@vcu.edu.
College of Public Health, Department of Epidemiology and Biostatistics, Temple University, Philadelphia, PA, USA. Electronic address: ldumenci@temple.edu.
Comment on the paper by George and colleagues and entitled Prevalence and factors associated with high impact chronic pain in knee osteoarthritis: The Johnston County Health Study .

School of Clinical Medicine, Jiamusi University, Jiamusi, Heilongjiang 154007, China.
College of Laboratory Medicine, ChongQing Medical University, Yuzhong, Chongqing, China.
School of Clinical Medicine, Jiamusi University, Jiamusi, Heilongjiang 154007, China. Electronic address: Liwenbo0001@outlook.com.
Genomic epidemiology of Salmonella: the need to consider vaccination history and nutritional status in resistance transmission studies.

Université Paris Cité, AP-HP, Unité de Recherche Clinique, Hôpital Robert Debré, INSERM CIC-EC 1426, Paris, France.
Université Paris Cité, AP-HP, Service de Physiologie Pédiatrique-Centre du Sommeil, Hôpital Robert Debré, INSERM NeuroDiderot, Paris, France.
AP-HP, Service de Physiologie Pédiatrique-Centre du Sommeil, Hôpital Armand Trousseau, Paris, France.
Université Paris Cité, AP-HP, Unité de Recherche Clinique, Hôpital Robert Debré, INSERM CIC-EC 1426, Paris, France; Laboratoire ECEVE INSERM, Université Paris Cité, UMR1123, Hôpital Robert Debré, Paris, France.
Université Paris Cité, AP-HP, Service de Physiologie Pédiatrique-Centre du Sommeil, Hôpital Robert Debré, INSERM NeuroDiderot, Paris, France. Electronic address: christophe.delclaux@aphp.fr.
The journal of allergy and clinical immunology. In practice
J Allergy Clin Immunol Pract. 2025-02;13(2):424-426.e1.
Emergency visits for childhood asthma exacerbations are linked to socioeconomic factors.

Despite the popularity of the frozen elephant technique procedure in recent years, evidence is scarce regarding its utilization for aortic arch replacement following previous acute aortic dissection repair. In this systematic review and meta-analysis, we aimed to analyse clinical outcomes of aortic arch replacement in patients with previous repair of acute aortic dissection.A systematic literature search on PubMed, MEDLINE via Ovid, Embase, Scopus, and Web of Science until March 2024 was performed for studies on open aortic arch replacement with or without frozen elephant technique procedure in adult patients after previous acute aortic dissection repair. Early and late postoperative mortality were primary, while postoperative complications were secondary outcomes of interest. Additionally, a meta-analysis was performed to pool the early and late postoperative mortality.A total of 574 studies were identified, of which 9 studies including a total of 677 patients met the eligibility criteria. In-hospital or 30-day postoperative mortality and stroke were 0-17.5% and 0-7.7%, respectively. Duration of follow-up across all studies varied from 1.1 to 5.1 years. All-cause late mortality rate ranges from 5.9% to 30.5%. Aortic reintervention rate was 4.8-38.7%. The pooled early and late mortality rate were 8.7% [95% confidence interval (CI) 5.7-13%; I2 = 52%] and 24.9% (95% CI 19.5-31.1%; I2 = 54%), respectively.Current evidence suggest that relatively younger patients with chronic post-dissection aneurysm or residual aortic dissection after acute aortic dissection repair can undergo an aortic arch replacement by a dedicated aortic team with acceptable mortality risk. However, postoperative neurological deficit remains an issue.
© The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
Department of Cardiac Surgery, University Hospital Leicester NHS Trust, Leicester, UK.
Department of Surgery and Cancer, Faculty of Medicine, Imperial College London & Imperial College Healthcare NHS Trust, London, UK.Department of Cardiothoracic Surgery, St Bartholomew's Hospital, London, UK.
Department of Cardiothoracic Surgery, St Bartholomew's Hospital, London, UK.
Department of Cardiac Surgery, University G. d'Annunzio , Chieti, Italy.
Wessex Cardiothoracic Centre, University Hospital Southampton, Southampton, UK.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Eur J Cardiothorac Surg. 2024-11-04;66(5):.
Aortic arch replacement in patients with previous repair of acute aortic dissection: a systematic review and meta-analysis.

Centro Internacional de Oftalmología Avanzada, Madrid and Badajoz, Spain; Grupo de Estudio Sobre ética en Oftalmología, Spain. Electronic address: jose.fernandez-vigo@fernandez-vigo.com.
Grupo de Estudio Sobre ética en Oftalmología, Spain; Universidad de Sevilla, Sevilla, Spain.
Archivos de la Sociedad Espanola de Oftalmologia
Arch Soc Esp Oftalmol (Engl Ed). 2025-01;100(1):1-2.
Corruption in science: fraud in research publications.

The Urology Group, Memphis, TN. Electronic address: walter.rayford@qlhinc.com.
Editorial Comment on Absence of Race/Ethnicity Reporting in Clinical Trials of True Minimally Invasive Surgical Therapies for the Treatment of Benign Prostatic Hyperplasia .

Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China. Electronic address: chiyu_zhang1999@163.com.
Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China. Electronic address: yyeli2000@126.com.
Saliva as a reliable, non-invasive specimen for detecting and monitoring Mycobacterium leprae.

New York Mens Health Medical, New York, NY. Electronic address: PNS@NYMensHealth.org.
Editorial Comment on A Nomogram Predicting Testicular Sperm Extraction Success in Men With Non-obstructive Azoospermia: A Multi-center Study .

Mike Petryk School of Dentistry, Division of Foundational Sciences University of Alberta, Edmonton, AB T6G 2E1, Canada.
Department of Medicine, Division of Rheumatology University of Alberta, Edmonton, AB T6G 2E1, Canada; Li Ka Shing Institute of Virology University of Alberta, Edmonton, AB T6G 2E1, Canada; Women and Children Health Research Institute University of Alberta, Edmonton, AB T6G 2E1, Canada.
Department of Medicine, Division of Rheumatology University of Alberta, Edmonton, AB T6G 2E1, Canada.
Mike Petryk School of Dentistry, Division of Foundational Sciences University of Alberta, Edmonton, AB T6G 2E1, Canada; Li Ka Shing Institute of Virology University of Alberta, Edmonton, AB T6G 2E1, Canada; Women and Children Health Research Institute University of Alberta, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta University of Alberta, Edmonton, AB T6G 2E1, Canada; Glycomics Institute of Alberta, Faculty of Medicine and Dentistry University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address: elahi@ualberta.ca.
Blood transcriptomic analyses do not support SARS-CoV-2 persistence in patients with post-COVID-19 condition with chronic fatigue syndrome.

Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia Seràgnoli , Bologna, Italy.
Division of Hematology, The Ohio State University, Columbus, OH, USA.
Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Unit of Lymphoma. Department of Hematology. Son Espases University Hospital (IdISBa), Palma de Mallorca, Spain.
Department of Hematology, Hospital Universitario de Salamanca, IBSAL, CIBERONC, Salamanca, Spain; University of Salamanca, Salamanca, Spain.
Servicio de Hematología y Oncología Médica, Hospital Clinico Universitario de Valencia, Valencia, Spain.
Department of Medicine/Division of Hematology and Oncology, UCLA Medical Center, Santa Monica, CA, USA.
Department of Medicine/Division of Hematology and Oncology, UCLA Medical Center, Los Angeles, CA, USA.
Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain.Universitat Autònoma de Barcelona, Bellaterra, Spain.
Department of Hematology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.
Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS) / CSIC, Universidad de Sevilla, Seville, Spain.
Department of Hematology and Medical Oncology Taussig Cancer Institute Cleveland Clinic, Cleveland, OH, USA.
Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
Hematology Department, Centre Hospitalier Régional Universitaire de Lille, Lille, AL, France.
Department of Hematology, University Hospital of Rennes, UMR U1236, INSERM, University of Rennes, Rennes, France.
Hematology Department, Hôpital Saint-Louis, Paris, France.
Hematology Department, Institut Curie, Paris, France.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia Seràgnoli , Bologna, Italy.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. lisa.argnani@unibo.it.
Is CAR T a drug or a therapeutic pathway? Intention to treat versus per protocol analysis of real world studies of CAR-T cell therapy in relapsed refractory diffuse large B cell lymphoma.

Auxergen Inc, Rita Rossi Colwell Center, Baltimore, MD 21202, USA; Auxergen Srl, Tecnopolis Science and Technology Park of the University of Bari, Valenzano BA, Italy. Electronic address: yehty@auxergen.com.
Auxergen Inc, Rita Rossi Colwell Center, Baltimore, MD 21202, USA; Auxergen Srl, Tecnopolis Science and Technology Park of the University of Bari, Valenzano BA, Italy.
Department of Emergency Kaohsiung Municipal United Hospital, Kaohsiung City, Taiwan.
Department of Internal Medicine Kaohsiung Municipal United Hospital, Kaohsiung City, Taiwan.
Long-Term Care Center, Kaohsiung City Government Health Bureau, Kaohsiung City, Taiwan.
Rapidly evolving recombinant monkeypox virus strains compound the challenges of the 2024 mpox outbreak.

Centro de Salud Trujillo, Consultorios de Herguijuela/Conquista de la Sierra Cáceres, Cáceres, España. Electronic address: a.alcantara.montero@hotmail.com.
Paradigm change in the management of benign prostatic hyperplasia.

Department of Anaesthetists, University Hospitals North Midlands, Stoke-on-Trent, UK. Electronic address: elizabeth.hancock1@nhs.net.
Department of Anaesthetists, University Hospitals North Midlands, Stoke-on-Trent, UK.
J Cardiothorac Vasc Anesth. 2025-02;39(2):497-500.
Use of Transcutaneous CO2 Monitoring in Adult Anesthesia.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas; Division of Immunology, Allergy and Retrovirology, Texas Children's Hospital, Houston, Texas; Department of Pediatrics, William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, Texas. Electronic address: Sara.Anvari@bcm.edu.
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Department of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, Calif.
Department of Clinical Medicine, General University Hospital Alicante, Alicante, Spain.
Department of Pediatrics, New York University Grossman School of Medicine, New York, New York; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
J Allergy Clin Immunol Pract. 2025-02;13(2):437-439.e2.
Assessing protocol variability for food protein-induced enterocolitis syndrome oral food challenges.

Department of Urology, Mayo Clinic, Jacksonville, FL.
Department of Urology, Mayo Clinic, Jacksonville, FL. Electronic address: Pathak.Ram@mayo.edu.
Reply to Editorial Comment on Virtual Reality as an Adjunct to Traditional Patient Counseling in Patients With Newly Diagnosed Localized Prostate Cancer .

Academic stress is a prevalent issue affecting students' well-being and academic achievement in today's challenging educational environment. Furthermore, combining digital literacy and self-regulation enhances emotional intelligence, creating a holistic digitally regulated emotional intelligence strategy to reduce academic stress effectively. This study emphasizes the significance of developing these abilities in educational settings to prepare students for success in a complex and technology-driven world.To assess emotional intelligence and academic stress among healthcare students and investigate the mediating role of students' digital literacy and self-regulation.A cross-sectional study was conducted to examine correlations and describe quantitative data. Data on two hundred forty students were collected from Fatima College of Health Sciences in the 2023-24 academic year. Pearson's correlation coefficient was applied to assess the associations between variables, and univariate linear regression was employed to investigate the connections between emotional intelligence and pertinent variables. The Hayes Process Model 4 macro was used to study how students' digital literacy and self-regulation mediate the relationship between emotional intelligence and academic stress.Emotional intelligence, digital literacy, and self-regulation were high. Furthermore, the academic stress level was moderate. The mediation analysis revealed that the direct effect of emotional intelligence on academic stress in the presence of the mediators was significant (t = 3.830, p < 0.001). Hence, digital literacy partially mediated the relationship between emotional intelligence and academic stress. On the other hand, self-regulation had no mediation effect on the relationship above.The study noted significant connections between study attributes, mainly showing the substantial relationship between emotional intelligence and academic stress. Higher emotional intelligence did not consistently reduce stress levels for moderately stressed students, suggesting that other factors may influence their stress levels. Furthermore, digital literacy mediated between emotional intelligence and academic stress, implying that proficient use of online resources could help reduce stress in students with advanced digital skills. Finally, self-regulation did not act as a mediator in the relationship between emotional intelligence and academic stress.
Nursing Department, Fatima College of Health Sciences, Al Dhafra Region, Baynunah Complex, Madinat Zayed, UAE. Rasha.Ibrahim@actvet.gov.ae.
Psychology Department, Fatima College of Health Sciences, Abu Dhabi, UAE.
Physiotherapy Department, Fatima College of Health Sciences, Abu Dhabi, UAE.Jordan University of Science and Technology, Faculty of Applied Medical Sciences Department of Rehabilitation Sciences, Irbid, Jordan.
General Requirement Department, Fatima College of Health Sciences, Abu Dhabi, UAE.
Department of Administration, Curricula and Teaching Methods, College of Educational and Psychological Sciences, Amman Arab University, Amman, Jordan.
Institute of Applied Technology, Al Mafraq Campus, Abu Dhabi, UAE.
Department of Business Organization, Faculty of Economics and Business, University of Granada, Granada, Spain.
The mediating effect of digital literacy and self-regulation on the relationship between emotional intelligence and academic stress among university students: a cross-sectional study.

The objective of this article is to understand how emergency managers view the status of their emergency management programs and identify suggestions on how to improve this important profession in the future. This article first explores the hazards, vulnerabilities, and associated disasters confronting select jurisdictions in Federal Emergency Management Agency Region VIII. It then explains recent experiences of responding to the coronavirus disease 2019, the 2020 protests/riots, the Magna earthquake, and the Marshall Fire. The article also mentions the relative priority given to preparedness and mitigation and recovery activities, and it discusses common challenges and weaknesses emergency managers face. The article then concludes with a discussion of current activities as well as concerns and recommendations for the future.
Department of Emergency Services, Utah Valley University, Provo, Utah. ORCID: https://orcid.org/0000-0002-7575-0469.
Journal of emergency management (Weston, Mass.)
What's next for the disaster profession? A study of the opinions of local and state emergency managers and their recommendations for a more resilient future.

Pakistan, with its diverse points of entry, faced several challenges with implementing the International Health Regulations (IHR) ethically during the COVID-19 pandemic.To explore the perceptions of point of entry health workers regarding the ethics challenges in implementing the IHR during the COVID-19 pandemic.From December 2022 to March 2023, this qualitative study conducted 10 focused group discussions and key informant interviews with 40 participants from 10 points of entry in Pakistan and reviewed COVID-19 containment guidelines. The data generated were transcribed, translated into English and analysed manually. The thematic analysis focused on the core ethics principles, including optimization of population health versus autonomy, distributive justice versus equity, trustworthiness versus privacy and confidentiality, and the impact of sanctions and restrictions on vulnerable populations.The study identified ethics challenges relating to containment policies, public health measures (testing, quarantine and isolation), travel restrictions, equitable resource distribution, and emergency operations. These challenges were grouped under 3 main categories, according to the IHR thematic areas: prevent, detect and respond. Respondents said it was difficult to balance between the public health measures and individual rights, address discrimination and stigmatization, and ensure fairness and justice in vaccine distribution and travel restrictions.Navigating ethics challenges relating to IHR implementation during health emergencies requires transparent communication, cultural sensitivity, and a commitment to equity and justice. It is important to incorporate ethics considerations into national emergency response plans to guide decision-making, safeguard individual rights and promote collective wellbeing.
Copyright: © Authors 2024; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
Directorate of Border Health Services, Pakistan.Ministry of National Health Services, Khosar Block, Islamabad, Pakistan.
National Bioethics Committee, National Institute of Health, Islamabad, Pakistan.
Ministry of National Health Services, Khosar Block, Islamabad, Pakistan.
Federal Government Polyclinic, Islamabad, Pakistan.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
التحديات الأخلاقية في تنفيذ اللوائح الصحية الدولية في باكستان خلال جائحة كوفيد- 19. نادية نورين، فايزة بشير، كمران رحمن خان، تمكين غفور، نافيد الله خان، سابين أفضل. نظرًًا لتنوع نقاط الدخول إلى باكستان، واجه البلد العديد من التحديات الأخلاقية المتصلة بتنفيذ اللوائح الصحية الدولية خلال جائحةكوفيد- 19. التعرف على تصوُُّرات العاملين في مجال الرعاية الصحية في باكستان بشأن تنفيذ اللوائح الصحية الدولية على نحوٍٍ أخلاقي خلال جائحة كوفيد- 19. أجرت هذه الدراسة النوعية، التي امتدت في الفترة من كانون الأول/ ديسمبر 2022 إلى آذار/ مارس 2023 ، عشر مناقشات جماعية مركزة ومقابلات مع مصادر معلومات رئيسية شملت 40 مشاركًًا من عشر نقاط دخول في باكستان، واستعرضت المبادئ التوجيهية لاحتواء كوفيد- 19 . ونُُسِِخت البيانات الناتجة عن ذلك وتُُرجمت إلى اللغة الإنجليزية وحُُلِِّلت يدويًًّا. وركّّز التحليل المواضيعي على المبادئ الأخلاقية الأساسية، بما في ذلك الوصول بصحة السكان إلى المستوى الأمثل في مقابل التمتُُّع بالاستقلال الذاتي، وعدالة التوزيع في مقابل الإنصاف، والجدارة بالثقة في مقابل التمتُُّع بالخصوصية والسرية، وأثر العقوبات والقيود على الفئات السكانية الضعيفة. حددت الدراسة التحديات الأخلاقية المرتبطة بسياسات الاحتواء أثناء الجائحة، وتدابير الصحة العامة )مثل الخضوع للاختبار، والحجر الصحي، والعزل(، والقيود المفروضة على السفر، والتوزيع العادل للموارد، وعمليات الطوارئ. وقد صُُنِِّفت هذه التحديات تحت ثلاث فئات رئيسية، هي: الوقاية، والاكتشاف، والاستجابة. وأوضح المستجيبون أنه كان من الصعب تحقيق التوازن بين تدابير الصحة العامة والحقوق الفردية، والتصدي للتمييز والوصم، وضمان الإنصاف والعدالة في توزيع اللقاحات والقيود المفروضة على السفر. يتطلب التصدي للتحديات الأخلاقية المتصلة بتنفيذ اللوائح الصحية الدولية أثناء الطوارئ الصحية الشفافية في التواصل، ومراعاة الجوانب الثقافية، والالتزام بالإنصاف والعدالة. ومن المهم بمكان إدراج الاعتبارات الأخلاقية في الخطط الوطنية للاستجابة للطوارئ من أجل توجيه عملية صنع القرار، وحماية الحقوق الفردية، وتعزيز العافية الجماعية. Défis éthiques liés à l'application du Règlement sanitaire international au Pakistan pendant la pandémie de COVID-19. Le Pakistan, avec ses différents points d'entrée, a été confronté à plusieurs défis pour mettre en oeuvre le Règlement sanitaire international (RSI) de manière éthique pendant la pandémie de COVID-19. Étudier les perceptions des agents de santé aux points d'entrée en ce qui concerne les défis éthiques dans l'application du RSI pendant la pandémie de COVID-19. De décembre 2022 à mars 2023, la présente étude qualitative a permis de mener 10 discussions de groupe ciblées et des entretiens avec des informateurs clés auprès de 40 participants de 10 points d'entrée au Pakistan et d'examiner les lignes directrices relatives aux mesures de confinement liées à la COVID-19. Les données générées ont été transcrites, traduites en anglais et analysées manuellement. L'analyse thématique était axée sur les principes éthiques fondamentaux, y compris l'optimisation de la santé de la population par rapport à l'autonomie, la justice distributive par rapport à l'équité, la fiabilité par rapport au respect de la vie privée et de la confidentialité, et l'impact des sanctions et des restrictions sur les populations vulnérables. La présente étude a permis de cerner les problèmes éthiques liés aux politiques de confinement, aux mesures de santé publique (dépistage, quarantaine et isolement), aux restrictions relatives aux déplacements, à la répartition équitable des ressources et aux opérations d’urgence. Ces défis ont été regroupés en trois grandes catégories en fonction des domaines thématiques du RSI : prévention, détection et riposte. Les personnes interrogées ont déclaré qu’il était difficile de trouver un équilibre entre les mesures de santé publique et les droits individuels, de lutter contre la discrimination et la stigmatisation et d’assurer l’équité et la justice dans le cadre de la distribution des vaccins et des restrictions relatives aux déplacements. Relever les défis éthiques liés à la mise en oeuvre du RSI dans les situations d’urgence sanitaire exige une communication transparente, une sensibilité culturelle et un engagement en faveur de l’équité et de la justice. Il est important d’intégrer des considérations éthiques dans les plans nationaux d’intervention d’urgence afin d’orienter la prise de décision, de protéger les droits individuels et de promouvoir le bien-être collectif.
Ethics challenges in implementing the International Health Regulations in Pakistan during the COVID-19 pandemic.

Nowadays, the emergence of some microbial species resistant to antibiotics, both gram-positive and gram-negative bacteria, is due to changes in molecular activities, biological processes and their cellular structure in order to survive. The aim of the gene network analysis for the drug-resistant Enterococcus faecium as gram-positive and Salmonella Typhimurium as gram-negative bacteria was to gain insights into the important interactions between hub genes involved in key molecular pathways associated with cellular adaptations and the comparison of survival mechanisms of these two bacteria exposed to ciprofloxacin. To identify the gene clusters and hub genes, the gene networks in drug-resistant E. faecium and S. Typhimurium were analyzed using Cytoscape. Subsequently, the putative regulatory elements were found by examining the promoter regions of the hub genes and their gene ontology (GO) was determined. In addition, the interaction between milRNAs and up-regulated genes was predicted. RcsC and D920_01853 have been identified as the most important of the hub genes in S. Typhimurium and E. faecium, respectively. The enrichment analysis of hub genes revealed the importance of efflux pumps, and different enzymatic and binding activities in both bacteria. However, E. faecium specifically increases phospholipid biosynthesis and isopentenyl diphosphate biosynthesis, whereas S. Typhimurium focuses on phosphorelay signal transduction, transcriptional regulation, and protein autophosphorylation. The similarities in the GO findings of the promoters suggest common pathways for survival and basic physiological functions of both bacteria, including peptidoglycan production, glucose transport and cellular homeostasis. The genes with the most interactions with milRNAs include dpiB, rcsC and kdpD in S. Typhimurium and EFAU004_01228, EFAU004_02016 and EFAU004_00870 in E. faecium, respectively. The results showed that gram-positive and gram-negative bacteria have different mechanisms to survive under antibiotic stress. By deciphering their intricate adaptations, we can develop more effective therapeutic approaches and combat the challenges posed by multidrug-resistant bacteria.
Copyright: © 2024 Davati, Ghorbani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty of Food Industry, Department of Food Science and Technology, Bu-Ali Sina University, Hamedan, Iran.
Nuclear Science and Technology Research Institute (NSTRI), Nuclear Agriculture Research School, Karaj, Iran.
Comparison of the antibiotic resistance mechanisms in a gram-positive and a gram-negative bacterium by gene networks analysis.

KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore; Anesthesiology and Perioperative Sciences Academic Clinical Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. Electronic address: tan.chin.wen@kkh.com.sg.
KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore; Severn PGME School of Anesthesia, Park House, 1200 Parkway, Bristol BS34 8YU, United Kingdom.
KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore; Anesthesiology and Perioperative Sciences Academic Clinical Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Biostatistics, Singapore Clinical Research Institute, 23 Rochester Park, #06-01, Singapore 139234, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2 MD1 Tahir Foundation Building Level 10, Singapore 117549, Singapore.
Biostatistics, Singapore Clinical Research Institute, 23 Rochester Park, #06-01, Singapore 139234, Singapore; Centre for Quantitative Medicine, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Tampere Center for Child, Adolescent, and Maternal Health Research: Global Health Group, Tampere University, Arvo Ylpön katu 34, Tampere, 33520, Finland.
Centre for Quantitative Medicine, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Anaesthesia, critical care & pain medicine
Anaesth Crit Care Pain Med. 2025-01;44(1):101450.
The association between neuraxial labor analgesia and subacute pain after childbirth: A randomized controlled trial.

Urology Department, Surgical Subspecialties Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates. Electronic address: raheemo@clevelandclinicabudhabi.ae.
Urology Department, Surgical Subspecialties Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Editorial Comment on Castration Levels of Testosterone Results in Atrophy of Androgen-sensitive Perineal Muscles: A Potential Biomarker for Male Hypogonadism .

Division of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic, Scottsdale, Ariz.
Medical School, Faculty of Health Sciences, Universidad Anahuac, Mexico City, Mexico.
CHRISTUS MUGUERZA Hospital Alta Especialidad, Universidad de Monterrey, Monterrey, NL, Mexico.
Division of Rheumatology, Allergy and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Fla.
Allergy and Immunology Department, Hospital Universitario Austral, Buenos Aires, Argentina.
Division of Allergy and Clinical Immunology, Hospital Zambrano-Hellion, Monterrey, NL, Mexico. Electronic address: alejandra.canel9@gmail.com.
J Allergy Clin Immunol Pract. 2025-02;13(2):440-442.e1.
Assessing the accuracy of ChatGPT's responses to common allergy myths.

Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy. Electronic address: marco.cattalini@unibs.it.
Pediatrics Clinic, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
Institute for Molecular Medicine A.Nocivelli , Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
J Allergy Clin Immunol Pract. 2025-02;13(2):430-433.e1.
Sirolimus as a possible treatment in cleavage-resistant RIPK1-induced autoinflammatory syndrome.

Department of Urology, University of Washington School of Medicine, Comprehensive Metabolic Stone Clinic, Puget Sound, VA. Electronic address: mathews@uw.edu.
Editorial Comment on The Association Between Stone Heterogenicity and the Success of SWL for High Density Upper Urinary Tract Stones .

Department of Urology, University of Washington, Seattle, WA. Electronic address: ajskokan@uw.edu.
Editorial Comment on Persistent Opioid Use Following Artificial Urinary Sphincter Placement: A Large Claims Database Analysis .

University of Sharjah, Dubai, UAE. Electronic address: mshahait@yahoo.com.
Editorial Comment on Trends and Safety of Same-day Discharge for Robot-assisted Laparoscopic Prostatectomy: A Comparison Between the Pre-pandemic and Pandemic Periods From the National Cancer Database .

University of Massachusetts Chan Medical School, UMassMemorial HealthAlliance Clinton Hospital, Leominster, MA. Electronic address: zembamberger@gmail.com.
Editorial Comment on Indwelling Urological Devise Biofilm Composition and Characteristics in the Presence and Absence of Infection .

Dirección de Calidad y Seguridad Clínica, Hospital Clínico de Barcelona, Barcelona, España; Cátedra de Medicina Legal, Responsabilidad Profesional y Seguridad Clínica, Facultad de Medicina y Ciencias de la Salud, Universidad de Barcelona, Barcelona, España; Consejo Asesor de la Fundación Mémora, España. Electronic address: josep.arimany@comb.cat.
Consejo Asesor de la Fundación Mémora, España; Departamento de Ciencias de la Educación, Universitat Rovira i Virgili, Barcelona, España.
Consejo Asesor de la Fundación Mémora, España; Departamento de Trabajo Social y Servicios Sociales, Universidad Complutense de Madrid, Madrid, España.
Consejo Asesor de la Fundación Mémora, España; Cancer Center, Clínica Universidad de Navarra, Madrid, España.
A comprehensive approach to end-of-life care. Medical-legal, ethical, social, psychological and care aspects.

Department of Clinical Ophthalmology, University College London (UCL), London, United Kingdom. AliNouraeinejad@yahoo.com.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Graefes Arch Clin Exp Ophthalmol. 2025-01;263(1):247.
Correction: Neurological pathologies in acute acquired comitant esotropia.

Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: amanda.agyemang@mountsinai.org.
J Allergy Clin Immunol Pract. 2025-02;13(2):418-420.e1.
Proper use of epinephrine autoinjectors is related to device type, prior physical demonstration, and sociodemographic factors.

Department of Urology, University of Michigan, Ann Arbor, MI; VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI. Electronic address: chrouser@med.umich.edu.
Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI; Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; Division of General Pediatrics, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Reply to Letter to the Editor on Use of Catheterization Algorithms to Manage Acute Urinary Retention: What is the Evidence?

Department of Urology, University of Kentucky, Lexington, KY. Electronic address: Sydney.Strup@uky.edu.
Department of Urology, University of Kentucky, Lexington, KY; Veterans Affairs Medical Center, Lexington, KY.
Editorial Comment on Gender Differences in the Adoption and Utilization of Robotic-assisted Laparoscopic Surgery (RALS) Among Practicing Urologists: A Study of American Board of Urology Case Logs From 2012-2022 .

Department of Urology, Baskent University Faculty of Medicine, Ankara, Turkey. Electronic address: erman_ceyhan@yahoo.com.
Department of Urology, Baskent University Faculty of Medicine, Adana, Turkey.
Middle East Technical University, Institutional Big Data Management Coordination Office, Ankara, Turkey.
Department of Urology, Ankara City Hospital, Ankara, Turkey.
Department of Urology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Department of Urology, Çanakkale Provincial Health Directorate Gelibolu Şehit Koray Onay State Hospital, Turkey.
Department of Urology, Cerrahpasa Faculty of Medicine, Istanbul University - Cerrahpasa, Istanbul, Turkey.
Department of Urology, Cukurova University Faculty of Medicine, Adana, Turkey.
Department of Urology, Baskent University Faculty of Medicine, Ankara, Turkey.
Department of Urology, Etlik Zubeyde Hanim Training and Research Hospital, Ankara, Turkey.
Department of Urology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
Department of Urology, Adana Medline Hospital, Adana, Turkey.
Department of Urology, Bandirma Onyedi Eylul University Faculty of Medicine, Turkey.
Department of Urology, Private EPC Hospital, Adana, Turkey.
Urocentre Urology Clinic, Adana, Turkey.
Andrology Working Group of the Society of Urological Surgery in Turkey
Reply to Editorial Comment on A Nomogram Predicting Testicular Sperm Extraction Success in Men With Non-Obstructive Azoospermia: A Multi-Center Study .

Singapore General Hospital, Singapore, Duke-NUS Graduate Medical School, Singapore. Electronic address: kaejack.tay@gmail.com.
Editorial Comment on Five-year Oncologic Outcomes Following Primary Partial Gland Cryo-ablation Prospective Cohort Study of Men With Intermediate-risk Prostate Cancer .

Department of Urology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: baisongcmu81@163.com.
Reply to Editorial Comment on The Association Between Stone Heterogenicity and the Success of Shock Wave Lithotripsy for High Density Upper Urinary Tract Stones .

Department of Urology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033.
Department of Urology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033. Electronic address: jclark13@pennstatehealth.psu.edu.
Editorial Comment on Development of a Patient-reported Outcome Measure for Patients With Ureteral Stricture Disease .

Division of Cardiology, Department of Medicine, Loyola University Medical Center, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois.
Division of Cardiology, Department of Medicine, Loyola University Medical Center, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois. Electronic address: jlopez7@lumc.edu.
Floating but Not yet Landed: Are Drug-Coated Balloons for In-Stent Restenosis the Answer?

Department of Medicine, Division of Infectious Diseases, University of Colorado, Aurora, Colo. Electronic address: chia-yu.chiu@cuanschutz.edu.
Department of Medicine, Division of Infectious Diseases, University of Colorado, Aurora, Colo.
Department of Medicine, Section of Infectious Diseases Section, University of Oklahoma Health Sciences Center, Oklahoma City, Okla; Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal, Tegucigalpa, Honduras.
J Allergy Clin Immunol Pract. 2025-02;13(2):421-423.e1.
Incidence of anaphylaxis in patients with alpha-gal syndrome receiving gelatin-containing vaccines: A large database analysis.

Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut.
Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut. Electronic address: lynda.rosenfeld@yale.edu.
Calling the Right Plays in Hypertrophic Cardiomyopathy: Are Our Blockers Optimized for the Game?

Memorial Healthcare System, Hollywood, Florida.
Memorial Healthcare System, Hollywood, Florida; Florida Atlantic University, Boca Raton, Florida. Electronic address: hkhalili@mhs.net.
Untangling Right Ventricular-Pulmonary Artery Coupling and Pulmonary Hypertension Definitions in Transcatheter Edge-to-Edge Repair.

Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; University of Pittsburgh, School of Computing and Information, Pittsburgh, Pennsylvania; Artificial Intelligence for Holistic Evaluation and Advancement of Cardiovascular Thrombosis (AI-HEART) Lab, Pittsburgh, Pennsylvania.
Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: harinsteinme@upmc.edu.
Genetic Determinants of Prosthetic Valve Thrombosis: Paving the Way for Personalized Anticoagulation.

Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada. Electronic address: Andrew.kouri@mail.utoronto.ca.
J Allergy Clin Immunol Pract. 2025-02;13(2):427-429.e2.
Asthma digital inhaler uptake among patients and providers: A scoping review.

AP-HP, Hôpital Avicenne, Intensive Care Unit, Bobigny, France; French National Institute of Health and Medical Research (INSERM), UMR_S1155, CORAKID, Hôpital Tenon, Sorbonne Université, Paris, France.
Université Paris Cité, AP-HP, Hôpital Louis Mourier, DMU ESPRIT, Médecine Intensive Réanimation, 92700, Colombes, France; Université Paris Cité, Institut Necker-Enfants Malades, INSERM U1151, CNRS UMR 8253, 75015 Paris, France.
AP-HP, Service de médecine intensive-réanimation, Hôpital de Bicêtre, Hôpitaux Universitaires Paris-Saclay, Le Kremlin-Bicêtre, France; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm U1018, Equipe d'Epidémiologie respiratoire intégrative, CESP, 94807, Villejuif, France.
Hospital Universitari de Bellvitge, Intensive Care Unit, Barcelona, Spain.
CHR Metz-Thionville Hôpital de Mercy, Intensive Care Unit, Metz, France. Electronic address: guillaume.louis@chr-metz-thionville.fr.
Anaesth Crit Care Pain Med. 2025-01;44(1):101452.
Severe acute kidney injury in patients with COVID-19 acute respiratory distress syndrome: A multicenter retrospective study: Kidney Injury Working Initiative in Critically ill eurOpean patients during Coronavirus Outbreak (KIWI COCO study).

Pediatric Urology Unit, Bambino Gesù Children Hospital and Research Center, Rome, Italy; University Of Padova, Padua, Italy. Electronic address: marco.castagnetti@opbg.net.
Division of Pediatric Surgery, Federico II University of Naples, Naples, Italy.
Editorial Comment on Is There a Consensus on the Management of Primary Obstructive Megaureter?

Federal University of São Paulo, Department of Urology, São Paulo, SP, Brazil. Electronic address: andrebarcelossilva@gmail.com.
Federal University of São Paulo, Department of Urology, São Paulo, SP, Brazil.

Department of Urology, Cleveland Clinic, Cleveland, OH. Electronic address: haywoos@ccf.org.
Editorial Comment on PSMA PET-targeted Biopsy for Prostate Cancer Diagnosis: Initial Experience From a Multicenter Cohort .

Research Support Unit, Biosanitary Institute of Granada (ibs.GRANADA), University Hospital Complex of Granada, Granada, Spain.
Research Support Unit, Biosanitary Institute of Granada (ibs.GRANADA), University Hospital Complex of Granada, Granada, Spain; Department of Radiology and Physical Medicine, School of Medicine, University of Granada, Granada, Spain; Biopathology and Regenerative Medicine Institute (IBIMER), University of Granada, Granada, Spain. Electronic address: isabeln@ugr.es.
Reply to comments on Is the sustainability of exposure to non-ionizing electromagnetic radiation possible?

Department of Urology, NYU Grossman School of Medicine, New York, NY. Electronic address: Herbert.Lepor@gmail.com.
Reply to Editorial Comment on Five-year Oncologic Outcomes Following Primary Partial Gland Cryo-ablation Prospective Cohort Study of Men With Intermediate-risk Prostate Cancer .

Department of Urology, Mayo Clinic, Rochester, MN.
Department of Urology, Mayo Clinic, Rochester, MN. Electronic address: Viers.Boyd@mayo.edu.
Editorial Comment on Vessel Sparing Nontransecting Anastomotic Reconstruction of the Posterior Urethra: Single-center Experience With Long-term Follow-up .

To investigate if salivary O-linked glycans are altered in primary Sjögren's syndrome (pSS), and thus contributing to explain symptoms of oral dryness, and an impaired oral mucosal barrier function leading to changes in microbial metabolism and colonization by both pathogenic and commensal microorganisms and increased prevalence of oral diseases. O-linked oligosaccharides from stimulated whole saliva (SWS) samples from 24 patients with pSS, 38 patients with non-pSS sicca, and 23 healthy controls were analyzed using liquid chromatography mass spectrometer (LC-MS). Non-fractionated reduced and alkylated saliva was dot-blotted to PVDF-membrane and O-linked oligosaccharides were released using reductive beta-elimination. The 50 most abundant glycans were identified and their intensity compared for each sample, reflecting the relative abundance of individual monosaccharide residues. Comparison of the compositions of O-glycans in SWS samples revealed higher relative levels of sialic acid (NeuAc) and lower levels of neutral amino-monosaccharides (HexNAc) in pSS and non-pSS sicca patients than in the healthy controls. MS2 fragmentation analysis of salivary O-glycans suggests that altered sulfation, fucosylation, sialylation and distribution of core types may all contribute to the observed alteration, directly or indirectly. Additionally, the short disaccharide sialyl-Tn was most abundant in the saliva samples from patients with pSS. Our findings indicate that the salivary mucin-type O-glycan profile is altered in pSS, reflecting a dysfunction of the post-translational modification of salivary mucins leading to rheological changes of saliva, oral dryness symptoms, and impaired oral mucosal barrier function. The pathophysiological significance of the aberrant O-glycosylation needs further elucidation.
Section for Oral Biology and Immunopathology/Oral Medicine & Pathology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Sarah.kamounah@sund.ku.dk.
Proteomics Core Facility at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Section for Clinical Oral Microbiology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Genome Editing Department, Novo Nordisk A/S, Global Nucleic Acid Therapies, Måløv, Denmark.
Section of Pharmacy, Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.
Section for Oral Biology and Immunopathology/Oral Medicine & Pathology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren's syndrome and non-pSS sicca.

Department of Cardiac Anesthesia, National Heart Center, Royal Hospital, Muscat, Oman. Electronic address: madanmaddali@hotmail.com.
Department of Cardiac Anesthesia, National Heart Center, Royal Hospital, Muscat, Oman.
Department of Pediatric Cardiology, National Heart Center, Royal Hospital, Muscat, Oman.
J Cardiothorac Vasc Anesth. 2025-02;39(2):546-548.
Termination of Ventricular Septal Defect Device Closure Due to an Insurmountable Obstruction.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address: wernebg@ccf.org.
Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH.
Reply to Editorial Comment on Indwelling Urological Device Biofilm Composition and Characteristics in the Presence and Absence of Infection .

The storage and release of triacylglycerol (TAG) in lipid droplets (LDs) is regulated by dynamic protein interactions. α/β hydrolase domain-containing protein 5 (ABHD5; also known as CGI-58) is a membrane/LD bound protein that functions as a co-activator of Patatin Like Phospholipase Domain Containing 2 (PNPLA2; also known as Adipose triglyceride lipase, ATGL) the rate-limiting enzyme for TAG hydrolysis. The dysregulation of TAG hydrolysis is involved in various metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD). We previously demonstrated that ABHD5 interacted with PNPLA3, a closely related family member to PNPLA2. Importantly, a common missense variant in PNPLA3 (I148M) is the greatest genetic risk factor for MASLD. PNPLA3 148M functions to sequester ABHD5 and prevent co-activation of PNPLA2, which has implications for initiating MASLD; however, the exact mechanisms involved are not understood. Here we demonstrate that LD targeting of both ABHD5 and PNPLA3 I148M is required for the interaction. Molecular modeling demonstrates important resides in the C-terminus of PNPLA3 for LD binding and fluorescence cross-correlation spectroscopy demonstrates that PNPLA3 I148M greater associates with ABHD5 than WT PNPLA3. Moreover, the C-terminus of PNPLA3 is sufficient for functional targeting of PNPLAs to LD and the interaction with ABHD5. In addition, ABHD5 is a general binding partner of LD-bound PNPLAs. Finally, PNPLA3 I148M targeting to LD is required to promote steatosis in vitro and in the liver. Overall results suggest that PNPLA3 I148M is a gain of function mutation and that the interaction with ABHD5 on LD is required to promote liver steatosis.
Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 48202.
Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 48202.Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA 48202.
Department of Physics and Astronomy, Detroit, MI 48201, USA.
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA 48202.
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis IN 46285 U.S.A.
Lipid droplet targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis.

Department of Tuina, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Sichuan, China. Electronic address: 625638595@qq.com.
Acupuncture in postoperative recovery: Exploring individual differences, long-term effects, and synergistic approaches.

Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA, USA.
Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, Antimicrobial Service of the National Institute of Infectious Diseases (ANLIS Dr. Carlos G. Malbran), Buenos Aires, Argentina.
Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA, USA. Electronic address: mtolmasky@fullerton.edu.
Journal of global antimicrobial resistance
J Glob Antimicrob Resist. 2025-01;40():8-10.
Amikacin, in combination with cations, prevents growth of a carbapenem-resistant/multidrug-resistant Klebsiella pneumoniae strain isolated from a patient with COVID-19.

Microbiology and Antimicrobial Agents Research Team, LB2VE, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida, Morocco; Molecular Bacteriology Laboratory, Institut Pasteur du Maroc, Morocco. Electronic address: bakr.khazaz@gmail.com.
Microbiology and Antimicrobial Agents Research Team, LB2VE, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida, Morocco.
Microbiology and Antimicrobial Agents Research Team, LB2VE, Department of Biology, Faculty of Sciences, Chouaib Doukkali University, El Jadida, Morocco; Molecular Bacteriology Laboratory, Institut Pasteur du Maroc, Morocco.
Centre de Séquençage Génomique, Institut Pasteur du Maroc, Morocco.
Bacteriology Laboratory, Institut Pasteur du Maroc, Morocco.
Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Université Paris Cité, Paris, France.
Molecular Bacteriology Laboratory, Institut Pasteur du Maroc, Morocco.
J Glob Antimicrob Resist. 2025-01;40():96-97.
First detection of the high-risk Klebsiella pneumoniae ST147 clone producing NDM-14 in a community setting in Morocco: A new public health concern.

National Institute of Cardiology Ignacio Chávez, Juan Badiao 1, Belisario Dominguez Secc 16, Tlalpan, 14080, Mexico City, Mexico.
National Institute of Cardiology Ignacio Chávez, Juan Badiao 1, Belisario Dominguez Secc 16, Tlalpan, 14080, Mexico City, Mexico. Electronic address: Dr.victorlara@gmail.com.
Presentation of Acute Flank Pain in a Young Woman: Breaking the Mold in Emergency Diagnosis.

Division of Cardiovascular & Thoracic Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
J Cardiothorac Vasc Anesth. 2025-02;39(2):343-346.
Updating Optimal Perioperative Care for Stable Angina.

Division of Cardiothoracic and Vascular Anesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Department of Cardiothoracic and Vascular Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
J Cardiothorac Vasc Anesth. 2025-02;39(2):551-552.
Multimodality Imaging to Redefine the Diagnosis in a Rare Case of Double Outlet Both Ventricles for Surgical Correction.

Department Of Surgery, The Aga Khan University Hospital, Karachi, Pakistan. Electronic address: muhammad.nazim@aku.edu.
Department Of Surgery, The Aga Khan University Hospital, Karachi, Pakistan.
Editorial Comment on HoLEP Safety and Efficacy in Octogenarians: A Retrospective ACS-NSQIP Analysis (2011-2020) .

Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia; School of Health Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia. Electronic address: m.ferraro@neura.edu.au.
Pain Research Group, Department of Surgery & Cancer, Imperial College London, London, UK.
Centre for Pain Research, Department for Health, University of Bath, Bath, UK.
Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia; School of Health Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Reducing the spread of retracted pain research.

WHO ramps up emergency use mpox diagnostics.

Departments of Orthopaedic Surgery and Population Health Sciences, Duke Clinical Research Institute, Duke University, Durham, NC, USA. Electronic address: steven.george@duke.edu.
Thurston Arthritis Research Center & Department of Medicine, Division of Rheumatology, Allergy & Immunology, University of North Carolina, Chapel Hill, USA; Center of Innovation to Accelerate Discovery and Practice Transformation, Department of Veterans Affairs Healthcare System, Durham, NC, USA. Electronic address: kdallen@email.unc.edu.
Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA. Electronic address: alvarec@live.unc.edu.
Thurston Arthritis Research Center & Department of Medicine, Division of Rheumatology, Allergy & Immunology, University of North Carolina, Chapel Hill, USA. Electronic address: amanda_nelson@med.unc.edu.
Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA; University of Nebraska Medical Center, College of Allied Health Professions, Omaha, NE, USA. Electronic address: ygolightly@unmc.edu.
Response to riddle and dumenci comment on Prevalence and factors associated with high impact chronic pain in knee osteoarthritis: The johnston county health study .

Department of Anesthesiology, Montreal Heart Institute, University of Montreal, Montreal, QC, Canada.
Department of Radiology, Montreal Heart Institute, University of Montreal, Montreal, QC, Canada.
Department of Cardiac Surgery, Montreal Heart Institute, University of Montreal, Montreal, QC, Canada.
J Cardiothorac Vasc Anesth. 2025-02;39(2):555-557.
Low Initial Regional Cerebral Saturation (rSO2) Unresponsive to Intervention in Cardiac Surgery: When Can we Consider a False-Positive Low rSO2 Value?

Using a Li metal anode, the all-solid-state battery (ASSB) promises a step change in specific energy over Li-ion batteries and the potential for increased battery safety. ASSBs rely critically on the efficient movement of Li charge carriers through a Li-conducting solid electrolyte (SE) separator and throughout a composite cathode (CC) comprising active particles, particulate SE, polymeric binder, and carbon. Unfortunately, there is no readily accessible laboratory method to visualise Li distributions at both particle and electrode scales to help understand and optimise Li electrode dynamics in ASSBs. We report a method to map all electrode elements in a 3D volume, including Li, within a typical ASSB composite cathode. The method combines a xenon plasma focused-ion beam (PFIB) for 3D milling, energy dispersive X-ray spectroscopy (EDS) to map non-Li elements, and secondary ion mass spectrometry (SIMS) to map Li. We manipulate 3D EDS and SIMS datasets into a common format and then recombine them in 3D to differentiate the different materials at high resolution. This new approach can be applied to understand and optimise the role of microstructure in controlling ASSB performance.
Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom; The Faraday Institution, Quad One, Harwell Science and Innovation Campus, Didcot OX11 ORA, United Kingdom. Electronic address: yige.sun@materials.ox.ac.uk.
Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom.
Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom; The Faraday Institution, Quad One, Harwell Science and Innovation Campus, Didcot OX11 ORA, United Kingdom.
Visualizing the Li distribution in an all-solid-state battery composite electrode using combined plasma focused-ion beam microscopy and secondary-ion mass spectroscopy.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, MN.
Critical Care Independent Multidisciplinary Program, Mayo Clinic, Rochester, MN.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, MN. Electronic address: elmadhoun.omar@mayo.edu.
J Cardiothorac Vasc Anesth. 2025-02;39(2):489-491.
Pulmonary Hemorrhage During Pulmonary Artery Stenting Necessitating Venovenous Extracorporeal Membrane Oxygenation.

Schulich School of Medicine and Dentistry, Western University, Windsor, Ontario, Canada.
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Division of Urology, Centre hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, Quebec, Canada. Electronic address: naeem.bhojani@gmail.com.
Reply to Editorial Comment on Absence of Race/Ethnicity Reporting in Clinical Trials of True Minimally Invasive Surgical Therapies for the Treatment of Benign Prostatic Hyperplasia .

Keck School of Medicine of the University of Southern California, Los Angeles, CA.
Department of Urology, Keck School of Medicine of the University of Southern, Los Angeles, CA. Electronic address: jeffrey.loh-doyle@med.usc.edu.
Reply to Editorial Comment on Persistent Opioid Use Following Artificial Urinary Sphincter Placement: A Large Claims Database Analysis .

Department of Urology, Guy's and St Thomas' Hospital, London, United Kingdom. Electronic address: ozlem.boztepe@nhs.net.
Department of Urology, Guy's and St Thomas' Hospital, London, United Kingdom.
Letter to the Editor on A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial .

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: gianlucafranceschini70@gmail.com.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Are 1 mm margins necessary after breast-conserving surgery for invasive cancer? A critical look at the proposed change.

Electron-beam irradiation of α-Mn triggers dramatic microstructural transformations. Transmission electron microscopy (TEM) reveals localized thinning and MnO formation within the irradiated area. Reduced thermal conductivity due to thinning suggests significant local temperature rise by electron-beam irradiation. Finite element analysis (FEA) identifies Auger excitation as the dominant heating mechanism, surging temperatures to ∼2300 K with ultrafast cooling. Our findings indicate that the oxidation of Mn under electron-beam irradiation is primarily attributed to beam heating via Auger excitation, rather than defect formation through sputtering. This conclusion is supported by the fact that the maximum energy transferable from the incident electron beam in TEM is below the minimum displacement energy for Mn.
Department of Materials Science and Engineering and Research Institute of Advanced Materials, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: bolee@snu.ac.kr.
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea; Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul 03722, Republic of Korea; Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai 980-8577, Japan.
Electron-beam induced Mn oxidation in TEM: Insights into the heating effect of Auger excitation.

Seattle Children's Hospital, Seattle, WA; University of Washington, Seattle, WA. Electronic address: kathleen.kieran@seattlechildrens.org.
Editorial Comment on Lymph Node Sampling in Pediatric Renal Tumors: Survey of Current Practices and Impact of Education .

Department of Uro-Oncology, Mahavir Cancer Sansthan, Patna, India. Electronic address: rahuljanaksinha@yahoo.co.in.
Editorial Comment on Integrating a Virtual Reality Mask in Functional Urological Surgeries Under Local Anaesthesia: A Prospective Cohort Study on Utility and Satisfaction .

Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt; Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum 25240, Turkey.
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Shenzhen University General Hospital-Lishui Hospital Joint Research Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang, China.
Corrigendum to Fangchinoline inhibits metastasis and reduces inflammation-induced epithelial-mesenchymal transition by targeting the FOXM1-ADAM17 axis in hepatocellular carcinoma [Cell Signal. 2024 Dec:124:111467].

Hospital Clínico Universitario de Valencia, Departamento de Cirugía, Facultad de Medicina, Universidad de Valencia, Valencia, Spain. Electronic address: Noe_ruiz@gva.es.
Hospital Clínico Universitario de Valencia, Departamento de Cirugía, Facultad de Medicina, Universidad de Valencia, Valencia, Spain.
Arch Soc Esp Oftalmol (Engl Ed). 2025-01;100(1):57.
Syphilitic iris roseola. Usefulness of anterior segment Optical Coherence Tomography.

Unidad de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Electronic address: vergom02@ucm.es.
Unidad de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Arch Soc Esp Oftalmol (Engl Ed). 2025-01;100(1):55-56.
Bilateral and accelerated posterior capsule opacification in the clinical context of diffuse systemic sclerosis.

Department of Urology, Montefiore Medical Center, Bronx, NY. Electronic address: andrewebaca@gmail.com.
Department of Radiology, Montefiore Medical Center, Bronx, NY.
Department of Urology, Montefiore Medical Center, Bronx, NY; Albert Einstein College of Medicine, Bronx, NY.
A Call for the Inclusion and Reporting of Race and Ethnicity Demographics in Artificial Intelligence Research for Prostate Cancer Detection on Magnetic Resonance Imaging.

Department of Critical Care Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address: k.minami@ncvc.go.jp.
Department of Critical Care Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Department of Vascular Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.
J Cardiothorac Vasc Anesth. 2025-02;39(2):552-554.
Inhaled Nitric Oxide Therapy Is Associated With a Low Prevalence of Postoperative Delirium Among Patients Who Undergo Aortic Arch Surgery: A Propensity Score Matching Analysis.

Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK; Department of Pathology, Hamad Medical Corporation, Doha, Qatar. Electronic address: emad.rakha@nottingham.ac.uk.
Irish National Breast Screening Programme and Department of Histopathology, St. Vincent's University Hospital, and School of Medicine, University College, Dublin, Ireland.
Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia.
Broomfield Breast Unit, Broomfield Hospital, Mid & South Essex NHS Trust, Chelmsford, CM1 7ET, England, UK; The London Breast Institute at Princess Grace Hospital, 42-52 Nottingham Place, London, W1U 5NY, England, UK.
Department of Surgical Sciences, Faculty of Medicine, Uppsala University, Sweden.
Edinburgh Breast Unit, and Edinburgh University and Western General Hospital Edinburgh, UK.
Reply to the Editor: Reassessing margin standards in breast-conserving therapy.

HfO2 has been widely used in the electronics industry as a dielectric material with excellent properties. It has attracted much attention since HfO2 was first reported to be ferroelectric in 2011. With the continuous advancement of research, various methods such as oxygen vacancy control and interface control have been proven to be able to stabilize the metastable polar o-phase structure in doped hafnium oxide thin films. However, there are still some shortcomings in the relevant issues concerning non-doped hafnium oxide thin film materials. Here, polycrystalline non-doped HfO2 thin films were grown on SrTiO3 substrates by pulsed laser deposition (PLD). Atomic force microscopy investigation suggests that the surface roughness of HfO2 thin films increases as the film thickness increases. X-ray photoelectron spectroscopy analyses indicate that the HfO2 thin film has a high purity and contain only Hf4+ ions. The band gap of HfO2 was measured by valence EELS and UV-visible spectra. Atomic structures of the HfO2/SrTiO3 heterointerface have been studied by the aberration-corrected transmission electron microscopy and energy-dispersive X-ray spectroscopy. The HfO2/SrTiO3 heterointerface is atomically abrupt and incoherent. Our findings suggest that non-doped HfO2 films with o-phase structure through PLD technology.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: mdhe22s@imr.ac.cn.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: ttyao11s@imr.ac.cn.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: xxyan17s@imr.ac.cn.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: bbqiao19s@imr.ac.cn.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: zqian22b@imr.ac.cn.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: yxjiang@imr.ac.cn.
Jihua Lab, Foshan 528251, China. Electronic address: tianmin@jihualab.ac.cn.
Jihua Lab, Foshan 528251, China. Electronic address: yangzq34@163.com.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China. Electronic address: clchen@imr.ac.cn.
Effect of film thickness on phase structure of epitaxial non-doped hafnium oxide films.

Research & Evidence (RF&E), New Delhi, India. Electronic address: vaibhav.sahni@rcsed.net.
The British journal of oral & maxillofacial surgery
Br J Oral Maxillofac Surg. 2025-01;63(1):68.
Comment on 'Do we consent to change? An evaluation of the Oral and Maxillofacial Outpatient Department Dentoalveolar Consent Forms'.

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address: sandeep.gurram@nih.gov.
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Reply to Editorial Comment on Castration Levels of Testosterone Results in Atrophy of Androgen-sensitive Perineal Muscles: A Potential Biomarker for Male Hypogonadism .

The Ohio State University Wexner Medical Center, Columbus, OH.
J Cardiothorac Vasc Anesth. 2025-02;39(2):554-555.
Virtual Reality in Procedural Learning: An Underutilized Toolbox in Medical Education.

Department of Anesthesiology, Weill Cornell Medicine, New York, NY.
Department of Anesthesiology, University of California, San Diego, CA.
J Cardiothorac Vasc Anesth. 2025-02;39(2):360-363.
Further Retractions of Dr. Joachim Boldt in the Journal of Cardiothoracic and Vascular Anesthesia.

Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom. Electronic address: hamidrezakhademi.03@gmail.com.
Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Br J Oral Maxillofac Surg. 2025-01;63(1):64-65.
Re: Does intra-articular injection of platelet-rich plasma/platelet-rich fibrin improve outcomes after temporomandibular joint arthrocentesis? A systematic review and meta-analysis.

In a weakened healthcare system, the mental health of healthcare workers has become a priority issue. The aim of this longitudinal study was to assess the mental health of primary care nurses during the Covid-19 pandemic, using a postal survey. Four validated self-report questionnaires were used. The nurses reported mainly burnout symptoms and around 20% reported a post-traumatic stress.
Copyright © 2024 Elsevier Masson SAS. All rights reserved.
Université Rouen Normandie, Nimec UR969, 3 avenue Pasteur, 76000 Rouen, France; Pôle des formations paramédicales, CHU de Caen, 2 rue des Rochambelles, 14032 Caen cedex 5, France.
Université Caen Normandie, Inserm U1086 Anticipe, 3 avenue du Général-Harris BP 5026, 14000 Caen, France; Centre Franç ois-Baclesse, 3 avenue du Général-Harris, 14000 Caen, France.
Union régionale des professionnels de santé infirmiers de Normandie, 62 quai Gaston-Boulet, 76000 Rouen, France.
Université Caen Normandie, Inserm U1086 Anticipe, 3 avenue du Général-Harris BP 5026, 14000 Caen, France; Université Caen Normandie, UFR Santé, département de médecine générale, 2 rue des Rochambelles, 14032 Caen cedex 5, France. Electronic address: xavier.humbert@unicaen.fr.
[Mental health of primary care nurses during the Covid-19 pandemic: a longitudinal study].

Objective: To compare the short-and medium-term ischemia and bleeding risk between unfractionated heparin and bivalirudin in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 742 patients with ACS who underwent emergency PCI in Xinxiang Central Hospital of Henan Province from January 2016 to June 2022 were selected and divided into unfractionated heparin group (385 cases) and bivalirudin group (357 cases) according to the anticoagulant regimen. All patients were followed up for 6 months. The incidence of ischemic and bleeding events at 30 days and 6 months after operation were compared between the two groups. Multivariate Cox proportional regression model was used to analyze the risk factors of ischemic and bleeding events in the two groups. Kaplan Meier method was used to calculate the cumulative survival rate, and log rank method was used to analyze the difference in survival rates. Results: The age of 742 patients was (62.5±14.8) years old, and male accounted for 58.5% (434 cases). The age of unfractionated heparin group was (61.8±14.8) years old, and male accounted for 59.2% (228 cases); The age of bivalirudin group was (63.3±14.8) years old, and male accounted for 57.7% (206 cases). The incidence of bleeding events at 30 days and 6 months in the unfractionated heparin group were 6.8% (26 cases) and 9.9% (38 cases), respectively, which were higher than 3.4% (12 cases) and 4.5% (16 cases) in the bivalirudin group (all P0.05); The incidence of ischemic events at 30 days and 6 months in the unfractionated heparin group were 7.5% (29 cases) and 11.2% (43 cases), respectively, which were not observed to be significantly different with those in the bivalirudin group [6.2% (22 cases) and 9.5% (34 cases)] (all P0.05). Compared with patients using bivalirudin, the HR value (95%CI) of bleeding events after emergency PCI in patients using unfractionated heparin was 1.964 (1.317-3.125) (P0.05), and the HR value (95%CI) of ischemic events was 0.948(0.595-1.510) (P0.05). The cumulative incidence of bleeding events was 9.9% in unfractionated heparin group and 4.5% in bivalirudin group (P=0.005); The cumulative incidence of ischemic events was 11.2% in unfractionated heparin group and 9.5% in bivalirudin group (P=0.459). Conclusions: The incidence of short-term hemorrhage events in ACS patients treated with bivalirudin anticoagulation after emergency PCI is lower than that of unfractonated heparin, which can reduce the risk of short-term hemorrhage.
Department of Cardiovascular Medicine, Xinxiang Central Hospital, Xinxiang453000, China.
Department of Cardiovascular Comprehensive, Xinxiang Central Hospital, Xinxiang453000, China.
目的： 比较普通肝素与比伐芦定应用于急性冠状动脉综合征（ACS）患者经皮冠状动脉介入治疗（PCI）术后中短期缺血及出血风险。 方法： 回顾性纳入河南省新乡市中心医院2016年1月至2022年6月收治的急诊行PCI治疗的ACS患者742例，根据抗凝方案分为普通肝素组（385例）和比伐芦定组（357例），所有患者术后均随访6个月。比较两组患者术后30 d、6个月缺血及出血事件发生情况，采用多因素Cox风险比例回归模型分析两组患者缺血及出血事件发生风险的相关因素，同时采用Kaplan-Meier法计算累积生存率，Log-rank方法分析生存率差异。 结果： 742例患者的年龄为（62.5±14.8）岁，男性占58.5 %（434例）。普通肝素组年龄为（61.8±14.8）岁，男性占 59.2%（228例）；比伐卢定组年龄为（63.3±14.8）岁，男性占 57.7%（206例）。普通肝素组30 d、6个月出血事件发生率分别为6.8%（26例）、9.9%（38例），均高于比伐芦定组的3.4%（12例）、4.5%（16例）（均P0.05）；普通肝素组30 d、6个月缺血事件发生率分别为7.5%（29例）、11.2%（43例），均高于比伐芦定组的6.2%（22例）、9.5%（34例）（均P0.05）。与比伐卢定组相比，普通肝素组急诊PCI术后发生出血事件的HR值（95%CI）为1.964（1.317~3.125）（P0.05），发生缺血事件的HR值（95%CI）为0.948（0.959~1.510）（P0.05）。普通肝素组术后6个月的出血事件累积发生率为9.9%，比伐芦定组为4.5%（P=0.005）；普通肝素组术后6个月的无缺血事件累积发生率为11.2%，比伐芦定组为9.5%（P=0.459）。 结论： 采用比伐芦定抗凝方案的ACS患者急诊PCI术后中短期出血事件发生率比普通肝素低，可降低术后中短期出血的风险。.
[Comparison of short-to medium-term ischemia and bleeding risks between unfractionated heparin and bivalirudin in patients with acute coronary syndrome after PCI].

INDC Danteshwari, RC Church, Colaba, Mumbai 400005, India. Electronic address: drshakilnagori@gmail.com.
Br J Oral Maxillofac Surg. 2025-01;63(1):66-67.
Re: comment on: Does intra-articular injection of platelet-rich plasma/platelet-rich fibrin improve outcomes after temporomandibular joint arthrocentesis? A systematic review and meta-analysis.

Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China. Electronic address: zhangxsp@163.com.
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China. Electronic address: hang_neurosurgery@163.com.
Corrigendum to Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats [Brain Res. 1624 (2015) 113-124].

Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Correction to Optical Spectroscopic Determination of Human Meniscus Composition .

Long COVID encompasses a range of symptoms in which fatigue is one of the most prevalents. It is clear from other conditions that the definition and measurement of fatigue can be complex, but it is not clear how fatigue is defined and measured in long COVID. To advance our understanding, this review summarises the definitions and measures of long COVID fatigue being used by researchers.Scoping review following JBI methodology and reports using the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping reviews.Medline, Scopus, CINAHL, PsycINFO, EMCARE, Web of Science, Epistemonikos, Cochrane Central Register of Controlled Trials, Dimensions, Overton and ProQuest Dissertation & Theses Database were searched from January 2020 to May 2023.This review included quantitative and qualitative studies that included any definition of long COVID and/or measurement tool that purported to quantify either the impact, severity or symptoms of long COVID fatigue.Two independent reviewers screened the title, abstracts and full texts of the selected studies based on the inclusion criteria. Data extraction was performed by two independent reviewers. The data were summarised in tabular format and a narrative summary.The search retrieved 9839 studies, of which 57 met the inclusion criteria. Only 21 (37%) provided a definition of fatigue. Definitions ranged across physical, mental, cognitive, emotional, psychosocial, central, peripheral, postexertional symptom exacerbation and general dimensions of fatigue. Fifty-five (96%) used a measurement or assessment of fatigue. Twenty-six measures of fatigue were identified: 21 self-report measures (eg, Fatigue Assessment Scale) and five fatigability measures that purport to reflect changes in physiological processes that contribute to or reflect fatigue (eg, change in force generating capacity of a muscle).The definitions identified demonstrate considerable diversity, each highlighting different dimensions of long COVID fatigue. Long COVID fatigue was predominantly measured through self-report methods, which were problematic. There is an urgent need to better understand long COVID fatigue and to identify the different mechanisms involved. In order to do this, we need consistency with the language around fatigue and its measurement within research and across disciplines.The protocol has been registered on open science framework (https://doi.org/10.17605/OSF.IO/HNF8Z).
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
School of Healthcare Sciences, Cardiff University, Cardiff, UK thomasb60@cardiff.ac.uk.
School of Dentistry, Cardiff University, Cardiff, UK.
School of Healthcare Sciences, Cardiff University, Cardiff, UK.
School of Psychology, Cardiff University, Cardiff, UK.
Defining and measuring long COVID fatigue: a scoping review.

The separation of diffraction effects from phase contrast is a major challenge for differential phase contrast (DPC) imaging in scanning transmission electron microscopy (STEM). The application of electron beam precession has previously been proven successful in homogenizing the direct beam and improving the imaging of both long-range electric and magnetic fields. However, magnetic STEM-DPC imaging performed in a low magnification (LM) STEM mode suffers from significant aberrations of the probe forming lens and the consequent impediment of small precession angles. By investigating the application of precession path segmentation to LM-STEM precessed scans for the imaging of LSMO and FeAl thin film samples, the initially reported benefits of precession were discovered to be less substantial than originally assumed. The segmentation methodology reveals that precession induced beam phase shifts account for a large part of the DPC induction profile smoothing, and the precession path is non-circular, leading to streaking artifacts in the reconstructed induction maps.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.
Department of Energy Conversion and Storage, Technical University of Denmark (DTU), Fysikvej 310, 2800 Kgs. Lyngby, Denmark.
Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway. Electronic address: magnus.nord@ntnu.no.
On the effect of precession for magnetic differential phase contrast imaging.

Division of General Surgery, Department of Surgery, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: beenrenlin@ntu.edu.tw.
Reply to: Comment on Factors associated with leakage after reversal of protective stoma in patients with locally advanced rectal cancer following curative resection and anastomosis.

Craniofacial Surgery Fellow, Alder Hey Children's Hospital, Liverpool, UK. Electronic address: aitor.degearico@alderhey.nhs.uk.
Craniofacial Surgery Consultant, Alder Hey Children's Hospital, Liverpool, UK.
Br J Oral Maxillofac Surg. 2025-01;63(1):61-63.
Dura-based automated vault expansion - Remodelling (DAVE-R): A technical note on planning posterior cranial distraction vectors.

Department of Pediatric Surgery, Pediatric Urology and Renal Transplant Unit, University Hospital Vall d´Hebron Barcelona, Barcelona, Spain. Electronic address: romy.gander@vallhebron.cat.
Department of Pediatric Surgery, Pediatric Urology and Renal Transplant Unit, University Hospital Vall d´Hebron Barcelona, Barcelona, Spain.
Reply to Editorial Comment on Is There a Consensus on the Management of Primary Obstructive Megaureter?

Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan.
Department of Anesthesiology, National Hospital Organization Obihiro Hospital, Hokkaido, Japan.
J Cardiothorac Vasc Anesth. 2025-02;39(2):549-550.
Aortic Regurgitation of Antegrade Cardioplegia: Solution-Dependence of Transesophageal Echocardiography Appearance.

The Ohio State University Wexner Medical Center, Columbus, Ohio.
J Cardiothorac Vasc Anesth. 2025-02;39(2):550-551.
Impella-Assisted Weaning from Cardiopulmonary Bypass After Left-Sided Valvular Surgery: An Echocardiographic Conundrum.

Department of Anesthesiology, Boston Medical Center, Boston, MA.
J Cardiothorac Vasc Anesth. 2025-02;39(2):492-493.
Venovenous or Venoarterial Extracorporeal Membrane Oxygenation for Pulmonary Hemorrhage? It Depends.

Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL.
Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL. Electronic address: ziho.lee@nm.org.
Reply to Editorial Comment on Development of a Patient-reported Outcome Measure for Patients With Ureteral Stricture Disease .

Department of Surgery, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy. Electronic address: checcu.e@hotmail.it.
Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Department of Health Sciences (DISSAL), University of Genoa, Genova, Italy.
Division of Oncology/Unit of Urology, Soldera Prostate Cancer Laboratory, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Department of Oncology, Division of Urology, University of Turin, San Luigi Gonzaga Hospital, Orbassano (TO), Italy.
Reply to Editorial Comment on PSMA PET-targeted Biopsy for Prostate Cancer Diagnosis: Initial Experience From a Multicenter Cohort .

Department of Anesthesia and Critical Care Medicine, University of Chicago, Chicago, IL. Electronic address: kristin.trela@bsd.uchicago.edu.
Department of Anesthesia and Critical Care Medicine, University of Chicago, Chicago, IL.
J Cardiothorac Vasc Anesth. 2025-02;39(2):347-351.
Swinging of the Pendulum: Should We Pursue Surgical Management Over Minimally Invasive Management of Atrial Fibrillation?

Mount Sinai Medical Center of Florida, Department of Anesthesiology, Miami Beach, FL. Electronic address: Gerald.rosen@msmc.com.
Mount Sinai Medical Center of Florida, Department of Anesthesiology, Miami Beach, FL.
Icahn School of Medicine at Mount Sinai South Nassau, Department of Internal Medicine, Oceanside, NY.
J Cardiothorac Vasc Anesth. 2025-02;39(2):352-354.
Enhancing Surgical Recovery With Lung Prehabilitation Perioperatively.

Yale School of Medicine, New Haven, CT. Electronic address: Michael.leapman@yale.edu.
Editorial Comment on Commercial Prices and Care for Medicare Beneficiaries With Prostate Cancer .

Department of Medical Biopathology, University Hospital of Larissa, Greece.
Department of Medical Biopathology, University Hospital of Larissa, Greece. Electronic address: petinaki@uth.gr.
J Glob Antimicrob Resist. 2025-01;40():98-99.
Pseudomonas aeruginosa ST1971 clinical strain carrying the blaNDM-1 gene on ICETn43716385 in Greece.

Department of Urology, Sakarya University School of Medicine, Adapazarı, Sakarya, Turkey. Electronic address: dr.ibrahimcimen@gmail.com.
Letter to the Editor on Trends and Safety of Same-day Discharge for Robot-assisted Laparoscopic Prostatectomy: A Comparison Between the Pre-pandemic and Pandemic Periods From the National Cancer Database .

Department of Anorectal Surgery, Ningbo No.2 Hospital, Ningbo, Zhejiang, China.
Department of Anorectal Surgery, Ningbo No.2 Hospital, Ningbo, Zhejiang, China. Electronic address: 449040479@qq.com.
Comment on Factors associated with leakage after reversal of protective stoma in patients with locally advanced rectal cancer following curative resection and anastomosis .

Biology Department, Loyola Marymount University, Los Angeles, CA, 90045, USA; Coastal Research Institute, Loyola Marymount University, Los Angeles, CA, 90045, USA. Electronic address: maria.vasquez@lmu.edu.
Biology Department, Loyola Marymount University, Los Angeles, CA, 90045, USA.
Biology Department, Loyola Marymount University, Los Angeles, CA, 90045, USA; Coastal Research Institute, Loyola Marymount University, Los Angeles, CA, 90045, USA.
Corrigendum to Interactive effects of multiple stressors on the physiological performance of the invasive mussel Mytilus galloprovincialis [Marine Environ. Res. 178 (2022) 105665].

Assistance Publique - Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University Paris Cite, France; Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France; INI-CRCT Network, Nancy, France; FHU PROMICE, Paris, France. Electronic address: emmanuel.dudoignon@aphp.fr.
Assistance Publique - Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France.
University Paris Cite, France; Department of Microbiology - Assistance Publique - Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière - INSERM1137, IAME, Paris, France.
Department of Anaesthesiology and Surgical Intensive Care Unit, Groupe Hospitalier Bichat Claude Bernard, DMU PARABOL, France; Department of Anaesthesiology Hôpital Louis Mourier, DMU PARABOL, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM U1149, Centre de Recherche sur l'Inflammation (CRI), Paris, France.
Assistance Publique - Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; University Paris Cite, France; Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM UMR-S 942 Mascot, Lariboisière Hospital, Paris, France; INI-CRCT Network, Nancy, France; FHU PROMICE, Paris, France.
Anaesth Crit Care Pain Med. 2025-01;44(1):101454.
Microbiological monitoring during antibiotic therapy in patients with ventilated acquired pneumonia: A proof-of-concept.

University of Iowa Healthcare, Iowa City, IA.
University of Iowa Healthcare, Iowa City, IA. Electronic address: annah-vollstedt@uiowa.edu.
Reply to Letter to the Editor on A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial .

The current comprehensive study showcases a meticulous synthesis of novel class of α-benzilmonoxime thiocarbohydrazide (BMOTC) derivatives, and manifesting their multifaceted potential as antibacterial, antifungal, and anticancer agents. The synthesis of target compounds was performed in three phases using literature methods. In the first step, benzilmonoxime is synthesized using benzil and hydroxyl amine hydrochloride, followed by benzilmonoxime imine using thiocarbohydrazide. The final stage involves combining BMOTC imine with various aldehydes and ketones. The antibacterial and antifungal activities of the synthesized derivatives against five bacterial panels, both Gram-positive and Gram-negative, and one fungal pathogen have been screened. Twelve of the twenty-four synthetic derivatives showed noteworthy activity; eight derivatives exhibited growth inhibition (GI) >73 % against Acinetobacter baumannii, two exhibited GI >95 % against Escherichia coli, and two exhibited GI >93 % against Candida albicans at concentration 32 μg/mL. Further assessment revealed that two derivatives 5v and 5w, exhibited negligible cytotoxicity towards human embryonic kidney cells (HK-293) and human red blood cells (RBC), signifying their promising safety profile at concentration 32 μg/mL (GI against Candida albicans - 97.51 % and 93.71 % respectively). The synthesized compounds were subjected to in vitro cytostatic activity, where a rigorous scrutiny against a diverse panel of NCI 60 cancer cell lines representing various malignancies was carried out. A total of eleven compounds emerged as promising candidates, demonstrating significant growth percent (GP) at a concentration of 10 µM. Notably, compounds 5d, 5h, and 5x, turned up as standout performers, exhibiting potent anticancer activity across multiple cancer types, including colon, CNS, melanoma, and breast cancers. Of particular interest, compound 5d displayed notable antiproliferative effects against leukemia cancer cell lines RPMI-8226 & SR, while maintaining non-cytotoxicity against the same. Compound 5h showcased activity against ovarian, non-small cell lung, and prostate cancers, without inducing cytotoxic effects. Compound 5x demonstrated remarkable anticancer activity against leukemia and breast cancer cell lines, further bolstered by its non-cytotoxic nature. A compelling aspect of this study is the comparative analysis with the established drug molecule sunitinib, revealing that compounds 5d, 5h, and 5x exhibit superior potency. These findings not only highlight the therapeutic potential of the BMOTC derivatives but also underscore their viability as promising candidates for future drug development endeavours. This study serves as a pivotal step towards harnessing the untapped therapeutic potential of BMOTC derivatives in combating microbial infections and advancing cancer therapy.
Department of Chemistry, PDEA's Baburaoji Gholap College, Sangvi, Pune 27, India.
Department of Chemistry, PDEA's Baburaoji Gholap College, Sangvi, Pune 27, India. Electronic address: sangeetajagtap@rediffmail.com.
Bioorganic & medicinal chemistry letters
Biological evaluation of newly synthesized α-benzil monoxime thiocarbohydrazide derivatives as an antimicrobial and anticancer agent: In vitro screening and ADMET predictions.

Department of Anaesthesia and Perioperative Services, Royal Brisbane and Women's Hospital, Brisbane & The University of Queensland, Brisbane, Queensland, Australia. Electronic address: a.vanzundert@uq.edu.au.
Department of Anaesthesia, Hadassah Medical Centre, Mount Scopus Campus, Jerusalem, Israel.
Dan Benhamou. Service d'Anesthésie Réanimation Médecine Péri Opératoire. Université Paris Saclay. Hôpital Bicêtre - 78, rue du Général Leclerc. 94275 Le Kremlin Bicêtre, Cedex, France.
Anaesth Crit Care Pain Med. 2025-01;44(1):101459.
The Protective Role of Specialized Supraglottic Airway Devices in Gastrointestinal Endoscopy.

Department of Allergy/Immunology, Tulane University School of Medicine, New Orleans, La.
Department of Allergy/Immunology, Ochsner Health System, and School of Public Health and Tropical Medicine, Tulane University, New Orleans, La. Electronic address: john.carlson@ochsner.org.
J Allergy Clin Immunol Pract. 2025-02;13(2):289-294.
Mold Remediation in Homes After Flooding.

Pediatric Intensive Care Unit (PICU), John Paul II Upper Silesian Health Centre in Katowice, 40-752 Katowice, Poland; Research Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, Poland.
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Department of Public Health, International European University, Kyiv, Ukraine.
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Institute of Medical Science, Collegium Medicum, The John Paul II Catholic University of Lublin, Lublin, Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: Lukasz.szarpak@gmail.com.
Anaesth Crit Care Pain Med. 2025-01;44(1):101464.
Significance of ongoing enhancement of Pediatric Intensive Care Unit follow-up.

Univ. Grenoble Alpes, Pediatric Intensive Care Unit, Grenoble-Alpes University Hospital, La Tronche, France. Electronic address: gmortamet@chu-grenoble.fr.
Pediatric Intensive Care Unit, Montpellier University Hospital, Montpellier, France. Electronic address: c-milesi@chu-montpellier.fr.
Pediatric Intensive Care Unit, Robert-Debré Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Université Paris Cité, Paris, France. Electronic address: michael.levy@aphp.fr.
Anaesth Crit Care Pain Med. 2025-01;44(1):101465.
Significance of ongoing enhancement of Pediatric Intensive Care Unit follow-up. Authors' reply.

Département d'Anesthésie-Réanimation et Médecine Périopératoire, Centre Hospitalier Universitaire de Saint-Etienne, 42055 Saint-Etienne, France; Université de Lyon, UJM-Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-42023, Saint-Etienne, France. Electronic address: nory.saint-etienne@wanadoo.fr.
Département d'Anesthésie-Réanimation et Médecine Périopératoire, Centre Hospitalier Universitaire de Saint-Etienne, 42055 Saint-Etienne, France.
Département Universitaire de Médecine Générale, UJM, Saint-Etienne, France.
Département d'Anesthésie-Réanimation et Médecine Périopératoire, Centre Hospitalier Universitaire de Saint-Etienne, 42055 Saint-Etienne, France; Université de Lyon, UJM-Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, F-42023, Saint-Etienne, France.
Anaesth Crit Care Pain Med. 2025-01;44(1):101466.
A French regional survey of the role of general practitioners in the follow-up of patients with post-intensive-care syndrome (PICS).

The Stabilization of bubble magnetic textures in zero magnetic field has garnered significant attention due to its potential application in spintronic devices. Herein, we employed a home-built rotatable magnetic force microscopy (MFM) to observe the evolution of magnetic domains in NiO/Ni/Ti thin films. Magnetic stripe domains decay into isolated magnetic bubbles under an out-of-plane magnetic field at 100 K, and magnetic stripes reappear when the external magnetic field is reduced to zero. By rotating the sample within an external magnetic field of 0.42 T, the magnetic stripes transform into nanoscale magnetic bubble domains. This transition is driven by the minimization of the magnetostatic energy, accompanied by an increase in both the exchange energy and the Zeeman energy. The classical ferromagnetic Heisenberg model effectively describes the magnetic stripe-to-bubble transition under an applied magnetic field. The dense bubble domains remain stable in zero magnetic field due to long-range magnetostatic interaction. We introduce a straightforward method for constructing bubble domains in a zero magnetic field. This work presents a promising material platform for the future development of bubble-based spintronic devices.
University of Science and Technology of China, Hefei 230026, China; Anhui Key Laboratory of Low-Energy Quantum Materials and Devices, High Magnetic Field Laboratory, HFIPS, Chinese Academy of Sciences, Hefei 230031, China.
University of Science and Technology of China, Hefei 230026, China.
Anhui Key Laboratory of Low-Energy Quantum Materials and Devices, High Magnetic Field Laboratory, HFIPS, Chinese Academy of Sciences, Hefei 230031, China; High Magnetic Field Laboratory of Anhui Province, Hefei 230031, China.
Anhui Key Laboratory of Low-Energy Quantum Materials and Devices, High Magnetic Field Laboratory, HFIPS, Chinese Academy of Sciences, Hefei 230031, China; High Magnetic Field Laboratory of Anhui Province, Hefei 230031, China. Electronic address: wjmeng@hmfl.ac.cn.
University of Science and Technology of China, Hefei 230026, China; Anhui Laboratory of Advanced Photon Science and Technology, University of Science and Technology of China, Hefei 230026, China.
Anhui Key Laboratory of Low-Energy Quantum Materials and Devices, High Magnetic Field Laboratory, HFIPS, Chinese Academy of Sciences, Hefei 230031, China; High Magnetic Field Laboratory of Anhui Province, Hefei 230031, China. Electronic address: ybhou@hmfl.ac.cn.
University of Science and Technology of China, Hefei 230026, China; Anhui Key Laboratory of Low-Energy Quantum Materials and Devices, High Magnetic Field Laboratory, HFIPS, Chinese Academy of Sciences, Hefei 230031, China; High Magnetic Field Laboratory of Anhui Province, Hefei 230031, China; Anhui Laboratory of Advanced Photon Science and Technology, University of Science and Technology of China, Hefei 230026, China. Electronic address: qxl@ustc.edu.cn.
Stabilization of nanoscale magnetic bubbles in zero magnetic field by rotatable magnetic force microscopy.

Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC. Electronic address: Madison.goldberger@sunnybrook.ca.
Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC.
Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC.
Division of Perfusion Services, Duke University Medical Center, Durham, NC.
J Cardiothorac Vasc Anesth. 2025-02;39(2):494-496.
A Novel Configuration of Venovenous Modified Ultrafiltration for Bivalirudin Removal After HeartMate3 Insertion.

Department of Cardiothoracic Critical Care Medicine and ECMO Unit, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. Electronic address: vasileioszochios@doctors.org.uk.
Department of Cardiothoracic Critical Care Medicine and ECMO Unit, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK; Department of Respiratory Sciences, University of Leicester, Leicester, UK; National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, Leicester, UK.
Sorbonne Université, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, AP-HP, Service de médecine intensive-réanimation, Institut de Cardiologie, Hôpital Pitié-Salpêtrière, Paris, France.
J Cardiothorac Vasc Anesth. 2025-02;39(2):355-359.
Personalizing Permissive Hypercapnia in Acute Severe Respiratory Failure.

Department of Health Sciences, Northern Arizona University, Flagstaff, Arizona. Electronic address: Natalie.Papini@nau.edu.
Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
Department of Obstetrics and Gynecology, Pediatrics, Psychiatry and Population & Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, Massachusetts.
Department of Allied Health Sciences, University of Connecticut, Storrs, Connecticut.
Women's health issues : official publication of the Jacobs Institute of Women's Health
Addressing Weight Stigma in Perinatal Care: Strategies for Health Care Providers and Organizations.

Department of Anaesthesia and Intensive Care Unit, Strasbourg University Hospital, Strasbourg, France; UMR_S1255 EFS-INSERM, Strasbourg, France. Electronic address: charlesambroise.tacquard@chru-strasbourg.fr.
Department of Anaesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires de Marseille, Aix Marseille University, Marseille, France.
University Paris Cité, Paris, France; Anaesthesiology and Critical Care Medicine Department, DMU PARABOL, Bichat Hospital, AP-HP, Paris, France; Antibody in Therapy and Pathology, Pasteur Institute, UMR 1222 INSERM, Paris, France.
Anaesth Crit Care Pain Med. 2025-01;44(1):101467.
Self-reported penicillin allergy and beta-lactam allergy label: Is ICU so different?

Graphene's exceptional physical properties, such as high thermal conductivity and mechanical strength, have attracted significant interest for its integration in transistors and thermal interface materials. While achieving various conformations of graphene is desirable for such applications, synthesizing graphene with target conformations remains a challenge. In this work, we present a method for synthesizing multilayer graphene with ridged conformations, using a microscale ridge-patterned copper (Cu) layer that was epitaxially deposited on a sapphire substrate. The Cu layer, patterned with channels using photolithography, guides the graphene growth to conform to the ridged structure of the Cu substrate. Uniform ridged multilayer graphene is grown on the Cu substrate, and can be transferred to transmission electron microscope (TEM) grids for observation. This method offers the potential for the controlled formation of ridge patterns in graphene and could be extended to synthesizing graphene with tunable conformations for applications in graphene-based devices, electrodes, or graphene grids for graphene liquid cells and cryogenic electron microscopy for high-throughput imaging.
School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea; Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul National University, Seoul 08826, Republic of Korea.
School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea; Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul National University, Seoul 08826, Republic of Korea; Advanced Institute of Convergence Technology, Seoul National University, Suwon 16229, Republic of Korea; Institute of Engineering Research, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jungwonpark@snu.ac.kr.
Direct synthesis of multilayer graphene on a microscale ridge-patterned copper substrate.

Blood Purification Center, Shaoxing Second Hospital, Shaoxing, Zhejiang, China.
Department of Nephrology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. Electronic address: 15257513819@163.com.
Letter to the Editor on The Diagnostic Efficacy of Rapid Urine Sediment Fluorescence Staining in Urinary Tract Infections: An Exploratory Study .

Influenza A virus (IAV) poses a serious global threat to public health. There is an urgent need to develop new anti-IAV agents due to the limitations of the current antiviral drugs in clinical practice. Herein, based on compound I-13e, we designed and synthesized 23 substituted quinoline derivatives containing piperazine moieties and evaluated their in vitro anti-IAV activity. The results showed that compounds 4a, 4c, 6c, 6f, 6g, 6i and 9a-9d (IC50s: 0.88-4.92 μM) were more active against IAV than Ribavirin. In particular, compound 9b exhibited broad-spectrum antiviral activity (IC50: 0.88-6.33 μM) and acceptable cytotoxicity. The preliminary studies on its mechanism of action indicated an inhibition of viral RNA transcription and replication. These results suggested its potential as a promising anti-IAV candidate for further investigation.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: wangminghua@imb.pumc.edu.cn.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: wangyucheng@imb.pumc.edu.cn.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: wangjuxian@imb.pumc.edu.cn.
Synthesis and biological evaluation of substituted quinolines containing piperazine moieties against Influenza A virus.

The telomeric G-quadruplex (G4) along with the telomerase catalytic subunit hTERT are crucial in the extension of telomeres. Tumor cells can establish replicative immortality by activating the telomere-maintenance mechanism (TMM).Small molecule ligands can limit cancer telomere lengthening by by targeting at G4 and hTERT. The 144 structures were designed by summarising the common structure-activity relationship of G4 stabilisers and hTERT inhibitors.Molecular docking and mtQSAR activity prediction experiments finally identified a16 and a35 as the optimal structures. Subsequently their derivative compounds b1-b6 were synthesised,with b4 exhibiting the most pronounced inhibitory effect on tumour cells. The ability of b4 to distinguish single-stranded DNA, double-stranded DNA and telomere G4 was verified by fluorescence experiment, and the stable combination of b4 and hTERT was verified by molecular dynamics simulation. This suggests that the structural design of targeting G4 and hTERT is reasonable and has anti-tumor potential.
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, Harbin, PR China.
Center for Pharmacy Informatics, College of Pharmacy, HarBin Medical University, Harbin, PR China.
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, Harbin, PR China. Electronic address: hanweina@hrbmu.edu.cn.
Design and synthesis of novel structures with anti-tumor effects: Targeting telomere G-quadruplex and hTERT.

Urology Service, Hospital del Trabajador, Santiago, Chile. Electronic address: gomez.reynaldo@gmail.com.
Reply to Editorial Comment on Vessel Sparing Nontransecting Anastomotic Reconstruction of the Posterior Urethra: Single-center Experience With Long-term Follow-up .

Department of Allergy, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China.
State Key Laboratory of Respiratory Diseases Division of Allergy at Shenzhen University, Institute of Allergy & Immunology, Shenzhen University School of Medicine, and Shenzhen Key laboratory of Allergy & Immunology, Shenzhen, China.
Department of General Practice Medicine, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
Department of General Practice Medicine, Third Affiliated Hospital of Shenzhen University, Shenzhen, China. Electronic address: 99776271@qq.com.
Department of Allergy, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China. Electronic address: xianhairzeng@mailnesia.com.
Department of Allergy, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China; State Key Laboratory of Respiratory Diseases Division of Allergy at Shenzhen University, Institute of Allergy & Immunology, Shenzhen University School of Medicine, and Shenzhen Key laboratory of Allergy & Immunology, Shenzhen, China. Electronic address: pcy2356@163.com.
Probiotic DNA alleviates experimental airway allergy.

This study investigates the effect of pre-deformation by cold rolling after solution annealing on the microstructure and properties of the fine-grained Al-Li alloy 2A97. Electron backscatter diffraction (EBSD), X-ray diffraction (XRD) and transmission electron microscopy (TEM) were used to characterize grain boundaries, dislocations, precipitates and calculate their contribution to strength. It is found that the changes in precipitation behavior predominantly account for the enhanced tensile properties observed in the deformed alloys, where yield and tensile strengths are increased by 85 MPa and 63 MPa, respectively. The peak-aged samples without pre-deformation are mainly strengthened by the T1 phase, δ'/θ'/δ' composite and σ phase. In contrast, deformation of 10 % prior to aging facilitates the precipitation of the T1 and lath-like S phases while concurrently inhibiting the precipitation of the σ phase and δ'/θ'/δ' composite phases. In addition, for fine-grained alloys, low-angle grain boundaries induce the precipitation of the finer T1 phase compared to the T1 phase located inside the grain, which contributes to the good performance of 2A97 alloy.
School of Materials Science and Engineering, Chang'an University, Shaanxi 710064, China; Modern Engineering Training Center, Chang'an University, Shaanxi 710064, China.
School of Materials Science and Engineering, Chang'an University, Shaanxi 710064, China.
School of Materials Science and Engineering, Chang'an University, Shaanxi 710064, China. Electronic address: yjguo@chd.edu.cn.
Department of Chemical and Materials Engineering, The University of Auckland, New Zealand. Electronic address: p.cao@auckland.ac.nz.
Effect of pre-deformation on microstructure and mechanical properties of a fine-grained 2A97 alloy.

FL118, a camptothecin derivative with dual mechanisms of action through topoisomerase I inhibition and proteasome-mediated degradation of anti-apoptotic proteins exhibits potent anti-tumor activity while remaining resistant to drug efflux transporters. This work describes the targeted delivery of FL118 to tumors via antibody-drug conjugates (ADCs) using the pH-sensitive CL2A linker. ADCs targeting Trop2, HER2, and EGFR exhibited potent in vitro cytotoxicity, with IC50 values as low as 0.025 nM in Trop2-positive FaDu cells. In vivo, Sac-CL2A-FL118 showed 130 % tumor growth inhibition (TGI) at 7 mg/kg in Trop2-expressing xenografts surpassing Trodelvy®. Pharmacokinetic evaluations revealed that FL118-ADCs exhibited a 2.6-fold increase in AUC and approximately 1.7-fold higher Cmax compared to Trodelvy®, confirming their favorable profiles and supporting their potential as a promising therapeutic approach.
Pinotbio, Inc Suwon, Gyeonggi-do 16506, South Korea. Electronic address: gangadhar@pinotbio.com.
Pinotbio, Inc Suwon, Gyeonggi-do 16506, South Korea.
Design, synthesis and biological evaluation of camptothecin analogue FL118 as a payload for antibody-drug conjugates in targeted cancer therapy.

The IR polarization spectrum of acetylacetone enol (AAe, (3Z)-4-hydroxy-3-penten-2-one) was recorded in the region 2000 - 450 cm-1 using stretched polyethylene as an anisotropic solvent. The measured orientation factors were consistent with Cs molecular symmetry of AAe and provided an experimental distinction between in-plane and out-of-plane polarized spectral features. The results suggest the assignment of at least one previously unrecognized fundamental transition. Excellent agreement with presently and previously observed transition wavenumbers in the investigated region was obtained by theoretical predictions in the harmonic approximation using B3LYP-D3 Density Functional Theory (DFT); calculated diagrams are provided for all 39 normal modes of AAe. The prediction of in-plane transition moment directions was found to be very sensitive to calculational details. The wavenumbers computed with the anharmonic models VPT2 (2nd-order Vibrational Perturbation Theory) and DVPT2 (Deperturbed VPT2) were consistent with those of the harmonic analysis, but the predictions obtained using GVPT2 (Generalized VPT2) deviated significantly.
Copyright © 2024 The Author. Published by Elsevier B.V. All rights reserved.
Department of Science and Environment, Roskilde University, Universitetsvej 1, P.O. Box 260, DK-4000 Roskilde, Denmark. Electronic address: spanget@ruc.dk.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125647.
Molecular vibrations of acetylacetone enol. Infrared polarization spectroscopy and theoretical predictions.

Herin, the successful synthesis of a bis Schiff base (L) has been achieved using 2-hydroxy-1-naphthaldehyde and 1,3-diaminoguanidine as raw materials, which was further characterized by infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance hydrogen spectrum. Moreover, spectroscopic experiments demonstrated that the probe L showed good selectivity and visual detectability for Al3+. Its detection limit (DL) is 2.04 × 10-8 mol·L-1, which represents a significant improvement over the detection limits of published fluorescent probes of Schiff base. Furthermore, the analysis of the Job's plot revealed a 1:1 stoichiometric relationship between Al3+ and L. The refinement mechanism entails the complexation of Al3+ ions with two nitrogen atoms present in the Schiff base imine moiety and two oxygen atoms derived from carboxylate and phenolic groups. Additionally, quantum mechanical calculations involving density functional theory (DFT) and molecular docking analysis demonstrated that the interaction between L and BSA was primarily achieved through hydrogen bonding underlying the binding process. The binding energy of BSA protein with small molecules was found to be -7.758 kcal/mol, indicating a strong binding affinity between BAS and L molecules. The thermodynamic parameters, ΔG, ΔH and ΔS for the binding phenomenon indicated that the main interaction force between L and DNA was hydrogen bonds and van der Waals forces with a spontaneous process. In conclusion, this particular Schiff base demonstrates significant potential for the precise detection of Al3+ within an environmental context. The investigations into the interactions between this bis-Schiff base L and BSA (bovine serum albumin) reveals the significant role of hydrophobic cavities in the protein's folded structure.
Copyright © 2024. Published by Elsevier B.V.
Department of Chemistry and Chemical Engineering, Heze University, Heze 274500, China.
Department of Chemistry and Chemical Engineering, Heze University, Heze 274500, China; CAS Key Laboratory of Photovoltaic and Energy Conservation Materials, Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Hefei 230031, China. Electronic address: sxduan@ipp.ac.cn.
Inspection and Testing Center of Linshu County, Linyi 276700, China.
CAS Key Laboratory of Photovoltaic and Energy Conservation Materials, Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Hefei 230031, China.
School of Agriculture and Bioengineering, Heze University, Heze 274500, China. Electronic address: liujian61@hezeu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125649.
A new aguanidine-based bis Schiff base for highly selective Al3+ recognition, BSA binding studies and theoretical calculations.

Pseudo-3D HSQC0 provides an alternative and easy way to record and analyze quantitative HSQC0-data. In the original time-zero extrapolated 1H-13C HSQC (HSQC0), three separate 2D constant-time (CT) HSQC-experiments (HSQCi, i = 1-3) are acquired, where either 1,2 or 3 consecutive CT-HSQC-propagators are repeated in each pulse sequence, and the 2D integral data from the three 2D experiments is analyzed via linear regression. In the presented pseudo-3D HSQC0, HSQCi is one of the dimensions and all data is contained within one dataset, which is recorded in interleaved manner by acquiring the same t1-value for each HSQCi-point before t1-incrementation. The 3D-nature of the data allows the utilization of backward linear prediction to calculate an actual time-zero 2D HSQC0 spectrum, which can be analyzed using normal 2D integration procedures for quantitative results. In all, the pseudo-3D enables straightforward, intuitive and easy analysis of the quantitative 2D HSQC0 spectrum/plane. As the recorded pseudo 3D data contains the normal HSQCi planes, also the classic linear regression analysis can be applied.
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Department of Food and Nutrition, University of Helsinki, P.O. Box 66, FI-00014 Helsinki, Finland.
Institute of Biotechnology, University of Helsinki, P.O. Box 65, FI-00014 Helsinki, Finland.
Department of Food and Nutrition, University of Helsinki, P.O. Box 66, FI-00014 Helsinki, Finland; Helsinki Institute of Sustainability Science (HELSUS), University of Helsinki, P.O. Box 4, FI-00014, Finland.
Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland; Helsinki Institute of Sustainability Science (HELSUS), University of Helsinki, P.O. Box 4, FI-00014, Finland.
Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 Helsinki, Finland. Electronic address: Sami.Heikkinen@helsinki.fi.
Journal of magnetic resonance (San Diego, Calif. : 1997)
Pseudo-3D HSQC0, a method to create a true 2D HSQC0-plane. Application to softwood extract analysis.

Raman spectroscopy is a powerful and non-invasive analytical method for determining the chemical composition and molecular structure of a wide range of materials, including complex biological tissues. However, the captured signals typically suffer from interferences manifested as noise and baseline, which need to be removed for successful data analysis. Effective baseline correction is critical in quantitative analysis, as it may impact peak signature derivation. Current baseline correction methods can be labor-intensive and may require extensive parameter adjustment depending on the input spectrum characteristics. In contrast, deep learning-based baseline correction models trained across various materials, offer a promising and more versatile alternative. This study reports an approach to manually identify the ground-truth baselines for eight different biological materials through extensively tuning the parameters of three classical baseline correction methods, Modified Multi-Polynomial Fit (Modpoly), Improved Modified Multi-Polynomial Fitting (IModpoly), and Adaptive Iteratively Reweighted Penalized Least Squares (airPLS), and combining the outputs to best fit the training data. We designed a one-dimensional Transformer (1dTrans) tailored to fit Raman spectral data for estimating their baselines, and evaluated its performance against convolutional neural network (CNN), ResUNet, and three aforementioned parametric methods. The 1dTrans model achieved lower mean absolute error (MAE) and spectral angle mapper (SAM) scores when compared to the other methods in both development and evaluation of the manually labeled original raw Raman spectra, highlighting the effectiveness of the method in Raman spectra pre-processing.
Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
Department of Agricultural Technology, Center for Precision Agriculture, Norwegian Institute of Bioeconomy Research (NIBIO), Nylinna 226 2849, Kapp, Norway. Electronic address: jiangsan.zhao@nibio.no.
Department of Horticulture, Norwegian Institute of Bioeconomy Research (NIBIO), Nylinna 226 2849, Kapp, Norway.
Department of Agricultural Technology, Center for Precision Agriculture, Norwegian Institute of Bioeconomy Research (NIBIO), Nylinna 226 2849, Kapp, Norway.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125679.
Estimating baselines of Raman spectra based on transformer and manually annotated data.

While searching for a new host suitable for near infrared (NIR) emission, we explored a new composition NaLaMgWO6. The samples were prepared by solid state reaction method. X-ray Diffraction confirms crystallization of NaLaMgWO6 in monoclinic system. Composition and phase homogeneity were established by Energy Dispersive Spectra. Presence of La in the host permits doping with the trivalent lanthanides Nd3+ and Er3+; the known NIR emitters. By virtue of a large number of energy levels, excitation could be achieved by light of various wavelengths from near ultraviolet through visible. Among these 589 nm was most effective for Nd3+ and 524 nm for Er3+. Very weak excitation from host tungstate band was also observed at wavelengths around 317 nm. Nd3+ emitted at 1089 nm and Er3+ at 1540 nm. PL intensity was restricted by concentration quenching due to dipole-dipole interaction. The critical distance for Nd-Nd energy transfer was 22.57 Å, while for Er-Er it was 28.44 Å. NaLaMgWO6 doped with Nd3+ or Er3+ can be a suitable material for optically pumped lasers in NIR region.
IHLR & SS, Department of Physics, Anand Niketan College of Science, Arts & Commerce, Warora, 442907, India. Electronic address: pusdekarashvini2407@gmail.com.
IHLR & SS, Department of Physics, Anand Niketan College of Science, Arts & Commerce, Warora, 442907, India. Electronic address: nileshugemuge@gmail.com.
Shri Ramdeobaba College of Engineering and Management, Ramdeobaba University, Nagpur 440013, India.
Department of Physics, RTM Nagpur University, Nagpur 440033, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125661.
Spectroscopic analysis of NIR emitting phosphors based on NaLaMgWO6 doped with Nd3+ and Er3.

For the typical ESIPT process, the proton transfer process is often completed via the intramolecular hydrogen bond (IHB) with oxygen or nitrogen as proton donor or proton acceptor. In recent years, the ESIPT process for sulfur-containing hydrogen bonds has received more and more attention, but it has been rarely reported. We systematically studied the ESIPT processes and photophysical properties of 2-(benzothiophene-2-yl)-3-hydroxy-4H-chromen-4-one (BTOH), 2-(benzothiophene-2-yl)-3-mercapto-4H-chromen-4-one (BTSH) and 2-(benzothiophen-2-yl)-3-hydroxy-4H-chromene-4-thione (BTS) at the HISSbPBE/6-31+G(d,p) and TD-HISSbPBE/6-31+G(d,p) computational level. The IHBs were investigated by analyzing structural parameters, infrared (IR) spectra and electron densities. All the results showed that the IHBs become stronger in the excited state. Among these three molecules, the ESIPT energy barrier of BTSH is the lowest, while that of BTS is the highest. By calculating the natural population analysis (NPA) charge, we found that SH group as a proton donor is easier to provide protons than OH group, and the S group as a proton acceptor is more difficult to obtain protons than O group. The simulated electronic spectra showed that the absorption and fluorescence wavelengths of BTSH and BTS have more or less red-shift compared with BTOH.
Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, Nanjing 210037, People's Republic of China.
Department of Chemistry and Material Science, College of Science, Nanjing Forestry University, Nanjing 210037, People's Republic of China. Electronic address: susanfang20@gmail.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125616.
Theoretical insights into fluorescent properties and ESIPT behavior of novel flavone-based fluorophore and its thiol and thione derivatives.

In a previous study, we reported that nilotinib, a BCR-ABL tyrosine kinase inhibitor, possesses moderate antimalarial activity against PfK1 and PfFCR3. As a part of our efforts to develop novel antimalarial agents, a series of novel triazine analogs was identified as potent antimalarial agents via structure modification of nilotinib. Compound 15a showed strong antimalarial activities against PfK1 and PfFCR3 with IC50 values of 0.28 and 0.29 µM, respectively.
Carna Biosciences, Inc., 1-5-5 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address: yuko.asamitsu@dd.carnabio.com.
Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Carna Biosciences, Inc., 1-5-5 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Design and synthesis of novel triazine derivatives as antimalarial agents.

Phosphate (PO43-) and ammonium (NH4+), two major components of the phosphorus and nitrogen cycles, respectively, play vital roles in aquatic ecosystems. Very few studies have reported methods for the simultaneous determination of PO43- and NH4+ in seawater. Additionally, when ammonium molybdate solution was employed as a chromogenic reagent for the simultaneous determination of both PO43- and NH4+ in a single analysis system, there was a possibility of cross-contamination. In this study, a spectrophotometric method for the simultaneous determination of PO43- and NH4+ in seawater was established. To prevent interference from ammonium molybdate, sodium molybdate was used in the phosphomolybdenum blue reaction, yielding satisfactory results. The indophenol blue method was used for the determination of NH4+. The reagent concentrations for the determination of PO43- and NH4+ were optimized, and the effect of salinity on the determination was investigated. The effect of salinity can be effectively ignored by setting the residence time for the reaction. The developed method was validated, with limit of detection observed to be 0.02 and 0.06 μM for PO43- and NH4+, respectively. The working range of the method was observed to be 15 μM for PO43- and 12 μM for NH4+, with the relative standard deviations (1 μM, n = 20) of 2.5 % and 1.9 %. The results obtained using the proposed method were in agreement with the reference method. Furthermore, the proposed method was successfully applied for the on-site monitoring of diurnal variation of PO43- and NH4+ in surface seawater.
Third Institute of Oceanography, Ministry of Natural Resources, 361005 Xiamen, Fujian, China.
School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004 Guilin, Guangxi, China. Electronic address: xujin@guet.edu.cn.
Third Institute of Oceanography, Ministry of Natural Resources, 361005 Xiamen, Fujian, China. Electronic address: zhangping_tio@yeah.net.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125683.
Spectrophotometric determination of phosphate using sodium molybdate and its field application to the simultaneous measurement with ammonium in seawater.

PCA-based denoising usually implies either discarding a number of high-index principal components (PCs) of a data matrix or their attenuation according to a regularization model. This work introduces an alternative, model-free, approach to high-index PC attenuation that seeks to average values of PC vectors as if they were expected from noise perturbation of data. According to the perturbation theory, the average PCs are attenuated versions of the clean PCs of noiseless data - the higher the noise-related content in a PC vector, the lower is its average's norm. This enables a regularization of the PC expansion of data where the PC terms are self-adapted to their noise content. To approximate the average PC vectors, the data matrix is randomly sampled several times to obtain numerous pseudo-random PC sets. The PCs of same ranks are then used to reconstruct the full-data PCs of that rank. A numerical algorithm of the reconstruction and its implementation in Python are provided. The proposed automatic adaptation to data offers a convenient solution for those who face with a problem of scaling or discarding PCs in PCA-based denoising. Questions of optimal sampling schedule and sampling amount remain issues that future work must address.
Department of Low-Temperature Physics, Faculty of Mathematics and Physics, Charles University, V Holešovičkách 747/2, 180 00 Prague 8, Czech Republic.
The use of self-adaptive principal components in PCA-based denoising.

Double-quantum filtered 23Na NMR experiments with one or two magic angle (54.7°) pulses in the filter step are widely used for selective observation of sodium ions that are interacting with ordered biological structures ( ordered sodium ) and hence exhibit a distribution of quadrupolar splittings in their NMR spectrum. This approach has recently been extended to 23Na MRI where the conventional experiment has been modified, omitting the 180° pulse to reduce the absorption of radiofrequency energy during human studies. Here, the magic angle double-quantum filtered 23Na NMR experiment (without a 180° pulse) is analysed in terms of coherence pathways that lead to refocusing in an inhomogeneous B0 field ( echoes ) and those that do not ( antiechoes ). It is shown that the echo and antiecho pathways can be separated by phase cycling and that the antiecho pathway contributes very little to the overall signal in an inhomogeneous B0 field. Hence, a double-quantum filtered 23Na NMR experiment that utilises just the echo pathway and so achieves complete refocusing of the effects of B0 inhomogeneity without making use of a 180° pulse is proposed. The new method is demonstrated both in 23Na NMR spectroscopy in an inhomogeneous B0 field and in 23Na MRI of a three-component phantom.
Department of Chemistry, Faraday Building, Lancaster University, Lancaster LA1 4YB, United Kingdom. Electronic address: s.wimperis@lancaster.ac.uk.
Sir Peter Mansfield Imaging Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
Double-quantum filtered 23Na NMR and MRI: Selective detection of ordered sodium in an inhomogeneous B0 field.

A novel and new type of tetracycline with a different mechanism of action was necessary, due to the drug resistance of existing tetracyclines. This study outlines the synthesis and antibacterial evaluation of anhydro-tetracycline derivatives, which are unconventional tetracyclines with unique mechanisms of action. These derivatives include C4-NH2, C4-OH, and C9-substituted variations, and our synthetic approach focuses on semi-synthesis using natural tetracyclines as the starting precursors. Several derivatives of C4-NH2, C4-OH, and C9-substituted compounds have demonstrated effective antibiotic activity against both Gram-positive and Gram-negative bacteria.
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China. Electronic address: gchen2018@sjtu.edu.cn.
Synthesis and antibacterial study of anhydrotetracycline derivatives.

Circular dichroism mapping (CDM) method was introduced by utilizing the highly collimated light beam of synchrotron radiation (SR) available at Diamond Light Source B23 beamline for scanning the thin films of the NTB phase. We apply SR-CDM to two achiral dimeric materials exhibiting the NTB phase: symmetric DTC5C9 and dissymmetric DTC5C9CB. The SR-CDM measurements directly capture the chiral information in the local NTB domains, providing the ultimate complement to the theoretical predictions of the helical structures: the spontaneous symmetry breaking in NTB phase is ambidextrous. The macroscopic chirality of the NTB phase is determined by the combination of doubly degenerate locally chiral domains in the illuminated area. Additionally, we investigate the temperature dependence, as well as the dynamic nature of the local chirality in the NTB phase by in-situ SR-CDM, confirming a chiral conversion influenced by the state of enantiomeric aggregation and a progressive unwinding of the helical structure in left-handed domains as the crystallization temperature is approached.
School of Materials and Chemistry, China Jiliang University, Hangzhou 310018, China. Electronic address: huanan-yu@cjlu.edu.cn.
Department of Chemistry, University of Hull, Hull HU6 7RX, UK.
Department of Chemistry, University of Hull, Hull HU6 7RX, UK. Electronic address: G.H.Mehl@hull.ac.uk.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125682.
Mapping the local ambidextrous chirality in thin films of NTB phase by circular dichroism spectra.

The development of new materials to advance improved methods to quantify selected molecules in complex matrices is always a scientific challenge. Finding greener, simpler, and lower-cost techniques are the main targets. Inorganic compounds make it possible to meet these requirements. In this work, a spectroscopic method has been designed for the determination of reducing sugars using an inorganic glassy material based on boron and molybdenum oxides to boost the color reaction. The new material has been characterized by XRD, FTIR, zeta potential, and SEM. The color reaction proposed has been improved by applying microwaves and its functionality has been optimized with carbohydrate solutions and assessed on honey samples from the region. The novel inorganic material triggers the reduction of molybdenum cation by reducing sugar in an aqueous media to result in a colored molybdenum-gluconate complex. Such complex is then quantified by UV-vis spectroscopy. The effectiveness of this novel method is validated by contrasting to the conventional Fehling-Causse-Bonnans method resulting on a relative error lower than 3 %.
INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Bahía Blanca, 8000, Argentina.
INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Bahía Blanca, 8000, Argentina. Electronic address: frechero@uns.edu.ar.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125657.
Spectroscopic method to determine reducing-sugars applying a green inorganic glassy material to boost the color reaction.

Nano-FTIR spectroscopy is a technique where atomic force microscopy (AFM) and infrared (IR) spectroscopy are combined to obtain chemical information with a lateral resolution of some tens of nm. It has been used to study numerous solid surfaces and recently also liquids including water have been examined by separating the liquid from the AFM tip by a thin lid. However, although the water stretching vibrations are significantly more intense than the bending vibration in conventional IR spectroscopy, only the bending vibration has been observed in nano-FTIR spectroscopy so far. In this article we show that also the stretching vibrations of liquid H2O, D2O, HOD, and aqueous salt solutions can be probed in nano-FTIR spectroscopy. Nano-FTIR absorption and phase spectra have been acquired at different harmonics and it was found the third optical harmonic (O3) in the nano-FTIR absorption spectra exhibited the highest resemblance with attenuated total reflection (ATR). Being able to probe water stretching vibrations with nano-FTIR spectroscopy is of importance since the stretching vibrations contain considerably more detailed information regarding for example hydrogen bonding strength than the bending vibration. In addition, it enables studies of the essential interactions between water and biomolecules. Furthermore, this work highlights both advantages and challenges that nano-FTIR spectroscopy in a liquid sample cell has and importance of further studies that lead to a better understanding of the near-field signals in liquids.
Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
Department of Chemistry, KTH Royal Institute of Technology, Teknikringen 29, SE-100 44 Stockholm, Sweden.
Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology, and Health (CBH), KTH Royal Institute of Technology, Roslagstullsbacken 21, SE-11421 Stockholm, Sweden.
Department of Chemistry, KTH Royal Institute of Technology, Teknikringen 29, SE-100 44 Stockholm, Sweden. Electronic address: magnusj@kth.se.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125640.
Nano FTIR spectroscopy of liquid water in the -OH stretching region.

An efficient molecular probe 8 has been designed and synthesized. The photophysical, electrochemical and morphological behavior of the probe has been examined in the absence and presence of different ions. The probe 8 at 90 % water fraction in acetonitrile showed aggregation induced emission (AIE). Probe 8 upon interaction with ions binds with Fe3+ ion selectively in a 1:1 stoichiometry and showed fluorescence turn-Off response with good limit of detection (LOD = 92.2 nM). The particle size (DLS method) of probe upon increasing water fraction in acetonitrile showed a gradual increase while upon formation of a stable complex, 8 + Fe3+ particle size decreased along with change in morphology of the probe. SEM and TEM studies showed that in pure acetonitrile probe self-assemble into a sheet like structure of uneven surface. While in aggregated state (fw, 90 %) it changes to a uniform hollow rectangular rod shape structure. Further interaction of the probe with Fe3+ ions in aggregated state acquired a well-defined smooth sheet. Electrochemical (CV) studies suggested that the redox property of the probe incurred a marginal change in band gap upon complexation with Fe3+. The cell imaging studies were performed to detect Fe3+ in HeLa cells. The paper strip test and real water sample analysis showed the potential analytical application of probe to detect Fe3+ with a naked-eye sensitive visible color change. The formation of a complex, 8 + Fe3+ involving N and O atoms of the probe molecule was confirmed by 1HNMR and HRMS data.
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Nano Laboratory, Drug and Chemical Toxicology Group, FEST Division, Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, UP, India.
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India. Electronic address: amisra@bhu.ac.in.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125671.
A sensitive molecular probe exhibiting significant change in their photophysical and morphological behavior upon interaction with Fe3+ ion.

Universitätsklinikum Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany. Electronic address: Margret.Buelow@hhu.de.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany. Electronic address: broichhagen@fmp-berlin.de.
Chemical probes for imaging cellular compartmentalization.

The Chen-van-Dyck (CVD) formulation as a rigorous numerical solution to the Schrödinger equation has been demonstrated being the only accurate multislice method for calculating diffraction and imaging in low-energy transmission electron microscopy. The CVD formulation not only considers the forward scattering effects but also includes the backscattering effects. However, since its numerical computation has to be performed in real-space, the CVD method may suffer from divergence and inefficiency in computing time, especially when used for low-energy scanning transmission electron microscopy (STEM) image simulation. The present study investigates the influence of cutoff value and slice thickness on the accuracy and efficiency of STEM image simulation using this formula. The results show that a small cutoff value is required in the low-energy regime to ensure accuracy, especially for thick specimens. The optimal slice thickness can be predicted approximately by a simple equation. To speed up STEM imaging simulation by up to 17 times using the CVD formulation, a hybrid computation model incorporating multiple graphic process units (GPUs) is suggested, which is of great significance for quantitative STEM imaging in low-energy transmission electron microscopy. The significance of including backscattering effect in STEM image simulation is estimated in comparison with forward-scattering effect.
Center for High-Resolution Electron Microscopy, College of Materials Science & Engineering, Hunan University, Changsha, Hunan 410082, China.
Pico Electron Microscopy Center, Innovation Institute for Ocean Materials Characterization Technology, Center for Advanced Studies in Precision Instruments, Hainan University, Haikou, Hainan 570228, China; Key Laboratory of Pico Electron Microscopy of Hainan Province, Hainan University, Haikou, Hainan 570228, China.
Pico Electron Microscopy Center, Innovation Institute for Ocean Materials Characterization Technology, Center for Advanced Studies in Precision Instruments, Hainan University, Haikou, Hainan 570228, China; Key Laboratory of Pico Electron Microscopy of Hainan Province, Hainan University, Haikou, Hainan 570228, China. Electronic address: wqming@hainanu.edu.cn.
EMAT, Department of Physics, University of Antwerp, Antwerpen 2020, Belgium.
Pico Electron Microscopy Center, Innovation Institute for Ocean Materials Characterization Technology, Center for Advanced Studies in Precision Instruments, Hainan University, Haikou, Hainan 570228, China; Key Laboratory of Pico Electron Microscopy of Hainan Province, Hainan University, Haikou, Hainan 570228, China. Electronic address: jhchen123@hainanu.edu.cn.
Fast STEM image simulation in low-energy transmission electron microscopy by the accurate Chen-van-Dyck multislice method.

Ultrasonic cavitation technology has shown significant advantages across scientific and engineering fields, where cavitation intensity is critical to its performance. However, strategies for precisely regulating cavitation intensity remain underexplored. This study addresses this gap by introducing micron-sized silicon carbide (SiC) micro-abrasives into the medium to adjust cavitation intensity. A mathematical model was developed to predict the influence of micro-abrasives on cavitation by modifying nucleation rates, fluid viscosity, and pressure fluctuations. Experiments were conducted to evaluate the effects of ultrasonic frequency, micro-abrasive particle size, and mass fraction on cavitation intensity. Fluorescence analysis revealed that adding SiC micro-abrasives significantly enhanced fluorescence intensity, indicating increased cavitation. At ultrasonic frequencies of 20, 30, and 40 kHz, fluorescence intensities increased from 197.4, 142.2, and 99.2 to 248.3, 190.7, and 140.1, respectively, demonstrating that lower frequencies produce higher cavitation intensity. When adding SiC micro-abrasives with particle sizes of 6.5, 13.4, and 34.7 μm, fluorescence intensities were 190.7, 164.6, and 157.4, respectively, showing a negative correlation between particle size and cavitation intensity. As the mass fraction of SiC increased from 0.5 % to 15 %, fluorescence intensity initially surged, then slightly decreased and stabilized. At a 5 % mass fraction, the enhancement was optimal, with fluorescence intensity increasing from 142.2 to 284.9. The experimental results aligned well with the theoretical predictions, confirming the model's accuracy. This study underscores the effectiveness of SiC micro-abrasives in enhancing cavitation intensity, offering scalable insights for optimizing ultrasonic cavitation in industrial applications.
School of Mechanical Engineering, North University of China, Taiyuan 030051, China; Shanxi Key Laboratory of Advanced Manufacturing Technology, North University of China, Taiyuan 030051, China.
School of Mechanical Engineering, North University of China, Taiyuan 030051, China; Shanxi Key Laboratory of Advanced Manufacturing Technology, North University of China, Taiyuan 030051, China. Electronic address: lz09020141@163.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125686.
Theoretical and experimental study on micron-sized SiC micro-abrasives regulating ultrasonic cavitation intensity.

Two-dimensional antiferromagnetic materials have attracted wide attention in both performance and application, which are of great significance for spin valves and next-generation magnetic random access memory devices. The spin-phonon coupling effect plays a crucial role in magnon dynamics. However, there is still a lack of research on the spin-phonon coupling effect of two-dimensional antiferromagnetic flakes. In this work, the magnetic phase transition and spin-phonon coupling effect of NiO flakes were studied by Raman spectroscopy. The magnetic phase transition temperature of the two-dimensional NiO flake is TN = 468 K. When the temperature is lower than Néel temperature, the abnormal shift of phonon peaks and the temperature dependence of 2 M peak prove the magnetic order characteristics of NiO flakes. The spin-phonon coupling constants of LO, 2TO and 2LO modes are 3.5, 5.5 and 10 cm-1, respectively, by using the abnormal hardening of the phonon scattering mode relative to the anharmonic effects. These results clearly demonstrate the significance of the two-dimensional NiO flake to spintronics and are expected to play an important role in the spintronics.
Hubei Key Laboratory of Optical Information and Pattern Recognition, Wuhan Institute of Technology, Wuhan 430205, China.
Hubei Key Laboratory of Optical Information and Pattern Recognition, Wuhan Institute of Technology, Wuhan 430205, China. Electronic address: wjhuang@wit.edu.cn.
Hubei Key Laboratory of Optical Information and Pattern Recognition, Wuhan Institute of Technology, Wuhan 430205, China. Electronic address: xchen@wit.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125645.
Magnetic phase transition and spin-phonon coupling effect of antiferromagnetic NiO flakes probed by Raman spectroscopy.

Hyperspectral imaging, a rapidly evolving field, has witnessed the ascendancy of deep learning techniques, supplanting classical feature extraction and classification methods in various applications. However, many researchers employ arbitrary architectures for hyperspectral image processing, often without rigorous analysis of the interplay between spectral and spatial information. This oversight neglects the implications of combining these two modalities on model performance, consumption, and inference time. This paper evaluates the impact of including different spatial (visual texture) and spectral (captured spectral information) features on deep learning architectures for hyperspectral image segmentation. To this end, it presents different architectural configurations with varying levels of spectral and spatial information and are evaluated in terms of identification performance, energy consumption, and inference time. Additionally, the transferability of knowledge from large pre-trained image foundation models, originally designed for RGB images, to the hyperspectral domain is explored. Results show that incorporating spatial information alongside spectral data leads to improved segmentation results. However, not all spectral wavelengths are necessary to obtain the optimal performance/energy consumption ratio, which is required for faster and more carbon-neutral models. Training foundation models from the RGB domain leads to lower performance and higher energy consumption models with longer inference times. It is also essential to further develop novel architectures that integrate spectral and spatial information and adapt RGB foundation models to the hyperspectral domain. Furthermore, this paper contributes to the field by cleaning and publicly releasing the Tecnalia WEEE Hyperspectral dataset. This dataset contains different non-ferrous fractions of Waste Electrical and Electronic Equipment (WEEE), including Copper, Brass, Aluminum, Stainless Steel, and White Copper, spanning the range of 400 to 1000 nm.
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, C/ Geldo. Edificio 700, E-48160, Derio - Bizkaia, Spain; University of the Basque Country, Plaza Torres Quevedo, 48013 Bilbao, Spain. Electronic address: artzai.picon@tecnalia.com.
TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, C/ Geldo. Edificio 700, E-48160, Derio - Bizkaia, Spain.
TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, C/ Geldo. Edificio 700, E-48160, Derio - Bizkaia, Spain; University of the Basque Country, Plaza Torres Quevedo, 48013 Bilbao, Spain.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125665.
On the analysis of adapting deep learning methods to hyperspectral imaging. Use case for WEEE recycling and dataset.

Department of Anaesthesia and Intensive Care Medicine, Hôpital Henri Mondor, AP-HP, 1, rue Gustave Eiffel, 94000, Créteil, France. Electronic address: elojaimi.rami@gmail.com.
Department of Anaesthesia and Intensive Care Medicine, Hôpital Bicêtre, AP-HP, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
Department of Endocrinology-Diabetology-Nutrition, Avicenne Hospital, University of Paris 13, Sorbonne Paris Cité, CRNH-IdF, CINFO, AP-HP, Bobigny, France; Recherche en Epidémiologie Nutritionnelle (EREN), Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Bobigny, France.
Department of Intensive Care Medicine, Université Côte d'Azur, Hôpital Pasteur 2, CHU de Nice, 30, voie Romaine, 06001 Nice cedex 1, France.
Sorbonne Université, Assistance Publique-Hôpitaux de Paris (APHP), Diabetology Department, La Pitié Salpêtrière-Charles Foix University Hospital, Institute of Cardiometabolism and Nutrition ICAN, Paris, France.
Department of Endocrinology ad Metabolic Diseases, Hôpital Saint-André, Bordeaux University Hospital, 1, rue Jean-Burguet, 33000 Bordeaux, France.
CHU Bordeaux, Department of Cardiovascular Anaesthesia and Critical Care, F-33000 Bordeaux, France; Univ. Bordeaux, INSERM, UMR 1034, Biology of Cardiovascular Diseases, F-33600 Pessac, France.
Department of Endocrinology and Diabetology, Clermont Ferrand University Hospital, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
Polyclinique d'Aubervilliers, Aubervilliers and Université Paris-Nord, Bobigny, France.
Department of Anaesthesia and Intensive Care Medicine, Hôpital Bicêtre, AP-HP, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. Electronic address: dan.benhamou@aphp.fr.
Anaesth Crit Care Pain Med. 2025-01;44(1):101468.
Recent advances in perioperative care of patients using new antihyperglycaemic drugs and devices dedicated to diabetes.

Atomic scale, scanning transmission electron microscopy (STEM) analysis of the moiré structures in twisted epitaxial gold nanodiscs encapsulated in twisted bilayer molybdenum disulfide is presented. High angle annular dark field STEM imaging reveals that the period of the moiré patterns between gold and molybdenum disulfide varies with different twist angles of the bilayer molybdenum disulfide, ranging from 1.80 nm (epitaxial alignment of gold) to 1.53 nm (twisted epitaxial alignment of gold). Additionally, bright field STEM imaging reveals a faint, larger moiré of moiré structure in cases where the bilayer molybdenum disulfide twist angle is small (∼6°), arising from the overlapping three-layers, which is not visible in conventional transmission electron microscopy images. Our experiments indicate that scanning transmission electron microscopy as a suitable tool for moiré analysis of twisted multilayer planar heterostructures, complementary to information provided by conventional transmission electron microscopy and diffraction.
Department of Materials Science and Engineering, Stanford University, Stanford 94305, USA. Electronic address: cuiy@stanford.edu.
Department of Materials Science and Engineering, Stanford University, Stanford 94305, USA.
Department of Materials Science and Engineering, Stanford University, Stanford 94305, USA. Electronic address: bobsinc@stanford.edu.
Scanning transmission election microscopy observations of twisted epitaxial gold nanodiscs in twisted molybdenum disulfide bilayers.

The signal intensity ratio (SIR) is a crucial factor in advancing probe technology due to its direct impact on sensitivity and precision, particularly in applications such as medical imaging, environmental monitoring, and food safety testing. However, the development of high-SIR probes is challenged by complexities in fabrication, cost, and mechanical stability. In this study, we address these limitations by investigating the role of halogen atom substitutions in modulating the intermolecular binding energy and aggregation behavior of Ce-Salen Schiff base complexes. We synthesized a novel Schiff base pH probe, Ce-3,5-Cl-Salpn (3,5-Cl-Salpn = N, N'-bis (3,5-dichlorosalicylidene)ethylene-1,3-diaminopropane), and introduced its analogues Ce-5-Cl-Salpn (5-Cl-Salpn = N, N'-bis (5-chlorosalicylidene)ethylene-1,3-diaminopropane) and Ce-Salpn (Salpn = N, N'-bis (salicylidene)ethylene-1,3-diaminopropane) for comparative analysis. Through fluorescence measurements, single-crystal analysis, and theoretical calculations, we demonstrate that halogen substitution leads to significant modulation of fluorescence intensity and SIR in the pH range of 6.0 to 7.0. Notably, Ce-3,5-Cl-Salpn exhibited the highest SIR, with a 182.5-fold increase, compared to the non-halogenated variant's 9.2-fold rise. Frontier molecular orbital (FMO) analysis revealed a reduction in the HOMO-LUMO energy gap as halogen substitution increased, resulting in enhanced optical properties and more efficient electronic transitions. Additionally, binding energy calculations confirmed that halogen atoms strengthen intermolecular interactions, thereby improving molecular stability and aggregation-caused quenching effects.
Department of Chemical Science and Technology, Kunming University, Kunming, Yunnan 650214, China; College of Physics Science and Technology, Kunming University, Kunming, Yunnan 650214, China.
Department of Chemical Science and Technology, Kunming University, Kunming, Yunnan 650214, China.
Department of Chemical Science and Technology, Kunming University, Kunming, Yunnan 650214, China. Electronic address: wuqiongkm@163.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125668.
The impact of halogen substitution quantities on the fluorescence intensity ratio of lanthanide Schiff base complexes.

Department of Biosciences, University of Milano, Italy; National Institute of Molecular Genetics, Milano, Italy. Electronic address: elena.cattaneo@unimi.it.
Department of Biosciences, University of Milano, Italy; National Institute of Molecular Genetics, Milano, Italy. Electronic address: dario.besusso@unimi.it.
Stem Cell Revolutions: An alliance for Parkinson's disease driven by European Commission consortia.

Elemental analysis, infrared spectroscopy, and X-ray single crystal diffraction indicated that a novel metal-organic framework (Tb-MOF) designated as 0.5n[H2bpy]·[Tb(dpa)(H2O)2]n·4nH2O was synthesized successfully, (where H4dpa = 5-(3, 4-dicarboxy- phenoxy) isophenic acid, bpy = protonated 4,4'-bipyridine). Tb-MOF adopts a 3D network structure based on TbIII ions and the (dpa)4- ligand through µ4: η1, η2, η2, η2 binding modes. Various luminescent EuxTb1-x-MOFs were prepared by adjusting Tb3+ and Eu3+ concentrations. Fluorescence analysis revealed Tb-MOF's strong fluorescence and excellent sensing ability for pollutants like nitrobenzene (NB), ornidazole (ORN), and fluridine (Flu) in water. It is worth noting that the fluorescence quenching rate of Tb-MOF for nitrobenzene can reach 97.1 %, which is also one of the highest among Ln-MOFs. XPS, LUMO orbital energy levels, fluorescence lifetime, and UV absorption were employed to explore the fluorescence quenching mechanism. Tb-MOF demonstrates robust anti-counterfeiting properties and stability, particularly against Flu, and allows rapid in situ imaging of pesticide residues on vegetables. Moreover, leveraging the adjustable emission spectra of EuxTb1-x-MOF, a barcode system for anti-counterfeiting labels has been developed, showing the versatility of stable metal-organic frameworks in advanced technologies for anti-counterfeiting applications.
School of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Chemical Reaction Engineering, Laboratory of New Energy & New Function Materials, Yanan University, Yan'an 716000, China.
School of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Chemical Reaction Engineering, Laboratory of New Energy & New Function Materials, Yanan University, Yan'an 716000, China. Electronic address: chenxiaoli003@163.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125669.
Design and synthesis of a new highly efficient adjustable Ln-MOF for fluorescence sensing and information encryption.

We study the large-time behavior of an ensemble of entities obeying replicator-like stochastic dynamics with mean-field interactions as a model for a primordial ecology. We prove the propagation-of-chaos property and establish conditions for the strong persistence of the N-replicator system and the existence of invariant distributions for a class of associated McKean-Vlasov dynamics. In particular, our results show that, unlike typical models of neutral ecology, fitness equivalence does not need to be assumed but emerges as a condition for the persistence of the system. Further, neutrality is associated with a unique Dirichlet invariant probability measure. We illustrate our findings with some simple case studies, provide numerical results, and discuss our conclusions in the light of Neutral Theory in ecology.
Departamento de Matemática y Ciencia de la Computación, Facultad de Ciencia, Universidad de Santiago de Chile, Las Sophoras 173, Estación Central, Santiago, Chile.
Instituto de Estadística, Universidad de Valparaíso, Valparaíso, Chile.
Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile. pmarquet@uc.cl.Centro de Modelamiento Matemático (CMM), Universidad de Chile-IRL 2807 CNRS Beauchef 851, Santiago, Chile. pmarquet@uc.cl.The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM, 87501, USA. pmarquet@uc.cl.Instituto de Sistemas Complejos de Valparaíso, Subida Artillería 470, Valparaíso, Chile. pmarquet@uc.cl.
Instituto de Ingeniería Matemática, Universidad de Valparaíso, Valparaíso, Chile. rolando.rebolledo@uv.cl.
Persistence and neutrality in interacting replicator dynamics.

The inherent potential for self-assembly is a well-known attribute of organic dye molecules. This work takes advantage of the changes in dye photochemical and photophysical properties produced by the aggregation phenomenon, to investigate the behavior of all-optical modulation in molecular aggregates. The theoretical principles for a dual beam all-optical modulation, as well as the conception of an optical logic gate by exploring the aggregation phenomenon are discussed throughout the article. The deposition of heat by an excitation laser beam in a dye sample induces the dissociation of the self-assembled species, which modulates the dye transparency at the spectral absorption range of the aggregates and, simultaneously, modulates the darkness at the monomer spectral absorption range, because the dissociation of an aggregate of order n potentially produces n monomer units. Experimental proof of the principles was performed by using the methylene blue dye and two laser beams in a pump-probe configuration. The laser wavelength used to excite or to probe the absorption of the aggregated species was 532 nm. To excite or to probe the monomer absorption band, a diode laser at 663 nm wavelength was used. When probing the sample with the 532 nm green laser beam, an in-phase signal modulation was obtained. Within such conditions, an optical gate could be conceived allowing the Boolean operation A·B. When probing the sample with the 663 nm red laser beam, an inverted signal modulation was obtained, which allowed the Boolean operation A¯·B. The achievable signal modulation amplitudes for methylene blue and toluidine blue dyes were measured and compared.
Copyright © 2025 Elsevier B.V. All rights reserved.
Anhembi Morumbi University (UAM), Rodovia Dr Altino Bondensan 500, São José dos Campos 12247-016, SP, Brazil.
Anhembi Morumbi University (UAM), Rodovia Dr Altino Bondensan 500, São José dos Campos 12247-016, SP, Brazil; Center of Innovation, Technology and Education (CITE), Rodovia Dr Altino Bondensan 500, São José dos Campos 12247-016, SP, Brazil.
Anhembi Morumbi University (UAM), Rodovia Dr Altino Bondensan 500, São José dos Campos 12247-016, SP, Brazil; Center of Innovation, Technology and Education (CITE), Rodovia Dr Altino Bondensan 500, São José dos Campos 12247-016, SP, Brazil. Electronic address: egberto.munin@ulife.com.br.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125687.
Theoretical basis of all-optical modulation of a probe laser beam due to photothermal modulation of the aggregation state in organic dyes, with experimental proof of the principle.

It is very challenging to prepare carbon dots (CDs) with aggregation-induced emission (AIE) property for simultaneous sensitive sensing and efficient removal. Herein, blue-emission CDs were facilely prepared by one-step solvothermal treatment of vine tea. Optical characterizations demonstrated that AIE phenomenon of CDs came from the restricted intramolecular motion. Through selected chemical modifications for structure-property relationship analysis, carboxyl and carbonyl groups on CDs were demonstrated as co-coordination active sites to bind with Al3+ for turn-on sensing process. Fluorescence enhancement of CDs by Al3+ chelation could be attributed to synergistic mechanism of AIE and chelation-enhanced fluorescence. Thus, the prepared CDs has been used as a selective, sensitive, and effective fluorescent probe for fast Al3+ sensing (response time, 5 min; linear range, 0.5-30.0 μM; limit of detection, 0.31 μM). More interestingly, high binding affinity between CDs and Al3+ made them assembly into large aggregates via flocculation for Al3+ removal (removal efficiency, 97.5 %) with extraordinary adsorption behavior (adsorption capacity, 1316 mg/g). Furthermore, the proposed CDs were successfully applied in detecting Al3+ in real wastewater samples with acceptable recoveries (98.7-103.0 %) and superior precision (relative standard deviations, less than 3.82 %), and removing Al3+ in spiked samples with satisfactory results. The work thus gives a demonstration of the potential fabrication of CDs with AIE property, and a better understanding of sensing and removal mechanisms for more rational design of CDs with application values.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, China.
Natural Product Research Laboratory, Guangxi Baise High-tech Development Zone, Baise 533612, Guangxi, China.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, China; Natural Product Research Laboratory, Guangxi Baise High-tech Development Zone, Baise 533612, Guangxi, China. Electronic address: shuyshi@csu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125688.
Carboxyl and carbonyl groups of carbon dots co-coordinated assembly with Al3+ to emission-enhanced aggregates for sensitive sensing and efficient removal.

The need for metal ion sensors is increasing daily due to the harmful impact of metal ions on human health, the environment, and the aquatic ecosystem. The present study highlights synthesizing an azomethine functionalized triazole allied organosilane (5a) probe as a turn-off fluorometric sensor for Sn(II) recognition with high anti-interference even when the other metal ions are present. The probe (5a) offers a detection limit of up to 6.4 × 10-10 M which is much lesser than the WHO acceptable limit (2 µg/L) of Sn(II) in drinking water. The fluorometric and absorbance-based UV-visible spectroscopy method is used for this analysis due to their ease of sample preparation, low cost, quick analysis, high sensitivity and selectivity, and less time-consuming nature. The real sample analysis (recovery % more than 97) results of the probe (5a) prove that it can detect the Sn(II) in different water samples increasing its practical applicability. The biological activities of the presently synthesized compounds were also studied providing valuable insights into their biological potential. Probe (5a) showed effective antioxidant potential. Bacterial domain inhibition by Probe (5a) was also analyzed using molecular docking, which showed good inhibitory activity by the probe (5a).
Department of Chemistry, Panjab University, Chandigarh 160014, India; Department of Chemistry & Centre of Advanced Studies, Panjab University, Chandigarh, India. Electronic address: gjpsingh@pu.ac.in.
Department of Chemistry, Panjab University, Chandigarh 160014, India; Department of Chemistry & Centre of Advanced Studies, Panjab University, Chandigarh, India. Electronic address: malikpooja6465@gmail.com.
Department of Chemistry, Panjab University, Chandigarh 160014, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125693.
A fluorometric sensor for Tin(II) detection using Azomethine-Triazole organosilane: Turn-off mechanism, antioxidant activity and molecular docking insights.

Research on multifunctional luminous materials has garnered a lot of interest in the fields of optical sensing, biological imaging, white light-emitting diodes illumination, etc. A novel multifunctional phosphor of Pr3+-doped Bi2Mo2O9 (BMO: Pr), created via the solid-state method, was investigated in this work. X-ray diffraction, scanning electron microscopy, diffuse reflectance spectroscopy, photoluminescence spectra, and fluorescence decay curves were employed to analyze the produced phosphors. Typical Pr3+ characteristic emissions, such as red and near-infrared (NIR), were found under 450 nm excitation. With the temperature increase, the intensity of different emissions changes significantly and exhibits various change trends. In the temperature range of 303-483 K, a multi-mode temperature sensing measurement of BMO: Pr phosphor was performed via three different temperature sensing modes: thermally coupled energy levels of 3P0/3P1, non-thermally coupled energy levels of 1D2/3P0, 3P1, and fluorescence lifetime. The corresponding maximum relative sensitivities were 1.01 %K-1 at 303 K, 0.92 %K-1 at 303 K, and 2.73 %K-1 at 483 K, respectively. Subsequently, a prototype white LED was assembled by integrating the commercial YAG: Ce and BMO: Pr red phosphors and a 460 nm blue LED chip. The calculated color coordinates, related color temperature, and color rendering index were (0.33, 0.33), 5373 K, and 87, respectively. In addition, biological tissue penetration experiments were conducted to discuss the possible use of NIR emission from BMO: Pr phosphor in biological imaging. All the results indicated that the BMO: Pr phosphors are promising for the fields of multi-mode optical temperature detection, white LED, and bioimaging.
School of Science, Dalian Maritime University, Dalian, Liaoning 116026, PR China.
School of Science, Dalian Maritime University, Dalian, Liaoning 116026, PR China. Electronic address: lixp@dlmu.edu.cn.
School of Science, Dalian Maritime University, Dalian, Liaoning 116026, PR China. Electronic address: yuhq7808@dlmu.edu.cn.
School of Science, Dalian Maritime University, Dalian, Liaoning 116026, PR China. Electronic address: bjchen@dlmu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125673.
Visible to near-infrared emissions of Bi2Mo2O9: Pr3+ multifunctional phosphors for multi-mode temperature sensing, white LEDs and bioimaging.

Emory Healthcare 1440 Clifton Rd NE forth floor Atlanta GA 30322, United States. Electronic address: spencer.king@emoryhealthcare.org.
Should all patients with severe aortic stenosis have TAVR now?

Department of Dermatology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

A bromophenylpyridine derivative (N1) was designed, synthesized, and the molecule was incorporated into the cavity of the cucurbit[8]uril (Q[8]) as a guest to form a 2:1 host-guest complex. This complex demonstrates good room temperature phosphorescence (RTP) properties in aqueous solution. The host-guest interaction and optical properties of N1@Q[8] in aqueous solution were studied by means of 1H NMR, ultraviolet-visible absorption spectroscopy, fluorescence spectroscopy, phosphorescence spectroscopy, scanning electron microscopy and inverted fluorescence microscopy. The results show that the bromophenyl part of the guest molecule enters the cavity of Q[8], while the other part of N1 remains outside the cavity, resulting in a 2:1 supramolecular structure. This assembly exhibits specific recognition of dazomet on the phosphorescence spectrum with a detection limit of 8.8329 × 10-7 mol·L-1. Collectively, this finding opens up a new possibility for the potential application of room temperature phosphorescent materials in analytical detection.
Copyright © 2025. Published by Elsevier B.V.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Institute of Applied Chemistry, Guizhou University, Guiyang 550025, China.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Institute of Applied Chemistry, Guizhou University, Guiyang 550025, China. Electronic address: chenqingluck@163.com.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Institute of Applied Chemistry, Guizhou University, Guiyang 550025, China. Electronic address: dwpangd@126.com.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Institute of Applied Chemistry, Guizhou University, Guiyang 550025, China. Electronic address: gyhxxiaoxin@163.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125695.
Supramolecular phosphorescent assemblies based on cucurbit[8]uril and bromophenylpyridine derivatives for dazomet recognition.

Networked evolutionary game theory is a well-established framework for modeling the evolution of social behavior in structured populations. Most of the existing studies in this field have focused on 2-strategy games on heterogeneous networks or n-strategy games on regular networks. In this paper, we consider n-strategy games on arbitrary networks under the pairwise comparison updating rule. We show that under the limit of weak selection, the short-run behavior of the stochastic evolutionary process can be approximated by replicator equations with a transformed payoff matrix that involves both the average value and the variance of the degree distribution. In particular, strongly heterogeneous networks can facilitate the evolution of the payoff-dominant strategy. We then apply our results to analyze the evolutionarily stable strategies in an n-strategy minimum-effort game and two variants of the prisoner's dilemma game. We show that the cooperative equilibrium becomes evolutionarily stable when the average degree of the network is low and the variance of the degree distribution is high. Agent-based simulations on quasi-regular, exponential, and scale-free networks confirm that the dynamic behaviors of the stochastic evolutionary process can be well approximated by the trajectories of the replicator equations.
© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Laboratory of Mathematics and Complex Systems, Ministry of Education, School of Mathematical Sciences, Beijing Normal University, Beijing, People's Republic of China.
School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, People's Republic of China. neilli@163.com.
Laboratory of Mathematics and Complex Systems, Ministry of Education, School of Mathematical Sciences, Beijing Normal University, Beijing, People's Republic of China. zhangby@bnu.edu.cn.
Replicator dynamics on heterogeneous networks.

γ-valerolactone (GVL) and its unmethylated counterpart, γ-butyrolactone (GBL), are important compounds with a wide range of potential uses. For example, GVL is proposed as an ideal alternative renewable energy source, while GBL can be utilized as an electrolyte. Understanding the combustion mechanisms of these compounds is crucial for optimizing their use as energy sources and monitoring the products formed during combustion. During pyrolysis, reactions with hydrogen atoms play a key role. Although the reactions of lactones with hydrogen atoms have been studied at higher temperatures using theoretical and computational methods, the spectroscopic data for the radicals produced during these reactions remain incomplete. Such data could, however, be valuable for tracking radical mechanisms. This study investigated these reactions at 3.1 K using the para-H2 matrix-isolation technique. The conditions provided by this method are particularly well-suited for studying radicals, in contrast to the conditions used in pyrolysis studies. IR spectroscopy was employed to monitor the reactions, enabling us to observe the vibrational spectra of the resulting radicals. These spectroscopic data could offer valuable insights for further exploring the combustion processes of GVL and GBL.
Laboratory of Molecular Spectroscopy, Institute of Chemistry, ELTE Eötvös Loránd University, PO Box 32, H-1518 Budapest, Hungary; George Hevesy Doctoral School, ELTE Eötvös Loránd University, PO Box 32, H-1518 Budapest, Hungary.
Laboratory of Molecular Spectroscopy, Institute of Chemistry, ELTE Eötvös Loránd University, PO Box 32, H-1518 Budapest, Hungary.
Laboratory of Molecular Spectroscopy, Institute of Chemistry, ELTE Eötvös Loránd University, PO Box 32, H-1518 Budapest, Hungary; Centre for Astrophysics and Space Science, ELTE Eötvös Loránd University, PO Box 32, H-1518 Budapest, Hungary. Electronic address: gyorgy.tarczay@ttk.elte.hu.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125677.
Spectroscopic characterization of radicals formed by hydrogen-atom abstraction from γ-valerolactone and γ-butyrolactone.

Since 1997, driven by advancements in nanoscience, single-molecule plasmon-enhanced Raman spectroscopy (SM-PERS) has developed into a powerful technique for ultrasensitive trace analysis through fingerprint vibrational chemical information. The nanocavity between the coupled plasmonic nanostructures, offering an exceptionally high Raman signal enhancement factor (i.e., plasmonic field hotspot), is crucial for the achievement of SM-PERS. Herein, we first briefly review the development of SM-PERS, followed by an introduction of the features and methodologies of SM-PERS, as well as the applications of SM-PERS in biological analysis, high-resolution chemical imaging, and the investigations of single-molecule reactions. Finally, a perspective highlighting the advancement of new methods and applications of nano-driven SM-PERS is presented.
Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China. Electronic address: chaoyuli@tongji.edu.cn.
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, College of Energy, Xiamen University, Xiamen 361005, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125664.
Nanocavity-based single-molecule plasmon-enhanced Raman spectroscopy: Features and advancements.

Non-contact temperature sensors have gained immense popularity due to their inherent benefits, including the absence of physical interaction with targets and rapid response characteristics. In this work, KBaY(MoO4)3:Pr3+ was successfully synthesized utilizing a high-temperature solid-phase method. Experimental studies have indicated that multi-phonon relaxation (MPR), cross-relaxation (CR), and the unique intervalence charge transfer state (IVCT) exhibited by Pr3+-Mo6+ contribute to the changes in luminescence properties. The characteristic emission peaks of Pr3+ were utilized for fluorescence intensity ratios (FIR), and their fluorescence temperature sensing properties were explored with the temperature range of 292-513 K, and the maximum absolute sensitivity and maximum relative sensitivity were finally realized as 4.987 % K-1 at 513 K and 1.700 % K-1 at 513 K respectively. Moreover, KBaY0.99(MoO4)3:0.01Pr3+ maintained a high stability with a maximum repeatability of 0.984 after multiple cycling tests, the thermal resolution also achieved 0.29 K. The multiple FIRs also achieved superior levels of temperature resolution in all cases. These results demonstrate that KBaY1-x(MoO4)3:xPr3+ materials have a great potential for application in fluorescence temperature sensing.
College of Science, China University of Petroleum, Beijing 102249 China.
Department of Energy Power and Mechanical Engineering, North China Electric Power University, Beijing 102206 China. Electronic address: zdm_uu@126.com.
College of Science, China University of Petroleum, Beijing 102249 China. Electronic address: yuect@cup.edu.cn.
College of Science, China University of Petroleum, Beijing 102249 China; Beijing Key Lab of Oil & Gas Optical Detection Technology, China University of Petroleum, Beijing 102249 China; State Key Lab Heavy Oil Processing, China University of Petroleum, Beijing 102249 China. Electronic address: kailiciac@126.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125712.
Self-calibrating temperature sensing strategy based on KBaY(MoO4)3:Pr3+ phosphor luminescence characteristics with excellent relative temperature sensitivity.

Coumarin compounds have heterocyclic core with different properties such as high quantum yields, broad Stokes shifts, and superior photophysical and biological activity. It is known that fluorescence properties increase with increased intramolecular charge transfer in systems where electron-withdrawing or donor groups are attached to different positions of the coumarin compound. When these compounds interact with analytes in the environment, the analytes in the environment can be detected by quenching or increasing fluorescence. For this purpose, dicyanomethylenevinyl-1,3-dicoumarin compounds were obtained and 1H NMR, 13C NMR, FT-IR, HR-MS elucidated their structures. To determine the photophysical properties of the synthesized compounds, absorption, and emission spectra were examined in solvents with different polarities, and also quantum yields and Stokes shifts were calculated. Additionally, the sensitivity/selectivity properties of the compounds towards various anions were investigated by spectrophotometric, spectrofluorometric, and 1H NMR titration methods. The limit of detection (LOD) of the sensors to sense cyanide anion was considered based on absorption titration. The pKa value of compound that could be pH sensor candidate was determined. Thermogravimetric analysis was performed as an important parameter for compounds in electro-optical (EO) systems. Additionally, nonlinear optical (NLO) properties of the compounds were calculated experimentally and theoretically. The some experimental results were explained by Density Functional Theory (DFT) and time-dependent DFT (TDDFT) calculations.
Department of Chemistry, Faculty of Science, Gazi University, Yenimahalle, Ankara 06560, Turkey.
Department of Chemistry, Faculty of Science, Gazi University, Yenimahalle, Ankara 06560, Turkey. Electronic address: ebruaktan@gazi.edu.tr.
Strasbourg University, Department of Ultra-Fast Optics and Nanophotonics, IPCMS, UMR CNRS, 7504, 67034 Strasbourg Cedex 2, France.
Department of Chemistry, Faculty of Science, Gazi University, Yenimahalle, Ankara 06560, Turkey. Electronic address: znseferoglu@gazi.edu.tr.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125619.
Synthesis of fluorescent dicyanomethylenevinyl-1,3-dicoumarin compounds with donor-acceptor-π-donor (D-A-π-D) system and investigation of their photophysical, NLO, and chemosensor properties: Part 1.

Department of Cardiac Surgery, Baylor University Medical Center, Dallas, Texas. Electronic address: Charles.Roberts@BSWHealth.org.
Department of Biology, Austin College, Sherman, Texas.
Department of Cardiovascular Research, Baylor Scott & White Research Institute, Plano, Texas.
Delayed Aortic Dissection After Transcatheter Aortic Valve Replacement for Stenotic Bicuspid Valve.

Upconversion nanoparticles (UCNPs), as a type of light-emitting nanomaterials excited by near-infrared (NIR) light, can circumvent interference from spontaneous fluorescence and scattered light emitted by biological molecules in sensing applications. Traditional homogeneous core-shell UCNPs struggle to locate the position of luminescent doped ions (such as Tm3+) within the NaYF4 matrix, only the luminescent ions close to the surface of the particles can be efficiently quenched, with a low bursting efficiency that produces a considerable background. The full effectiveness energy transfer exists only by sufficiently close proximity between donor and acceptor. Here, a distance dependence sandwich structured NIR fluorescent probe UCNPs-IR820 was developed based on luminescence resonance energy transfer (LRET), where the luminescent ions (Tm3+) were secured in a intermediate layer of a core-middle-shell UCNPs structure, which could be quenched by the specific distance external adjacent receptor molecule (cyanine NIR dye IR820). In the presence of the analyte ClO-, the double bonds of IR820 were oxidized, unable to absorb the luminescence from the core-middle-shell sandwich UCNPs, thus an off to on luminescence was restored. This core-middle-shell design could effectively enhance the effect of LRET-based detection strategies through physically meaningful distance constraints, providing new ideas for the design of future UCNP-based NIR fluorescent probes.
Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, PR China; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, PR China; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, PR China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China.
Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China.
Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China. Electronic address: yanzhao2016@hnu.edu.cn.
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, PR China; School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125710.
Harnessing LRET in a rationally designed sandwich fluorescent probe for selective ClO- sensing.

The line list is essential for accurately modeling various astrophysical phenomena, such as stellar photospheres and atmospheres of extrasolar planets. This paper introduces a new line database for the PS molecule spanning from the ultraviolet to the infrared regions, covering wavenumbers up to 45000 cm-1 and containing over ten million transitions between 150,458 states with total angular momentum J < 160. Accurate line intensities for rotational, vibrational and electronic transitions are generated by using the general purpose variational code DUO. Before applying the DUO program, the potential energy curves (PECs), the electric dipole transition moments (EDTMs) and the spin-orbit coupling (SOC) matrix need to be provided, which are computed by an ab initio method at the icMRCI level. The DUO program is executed to generate two files - a state file and a transition file, which are provided to the ExoCross program which supply cross sections, intensities, partition functions, lifetimes and quantum number assignments. The cross-sections and intensities for the observed transitions are necessary for the correct modeling of the spectra. Tests of the line lists show that our predictions not only provide a favorable comparison with the experimental spectrum but also a cornerstone for various astronomical observations.
Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012 China.
Department of Chemistry and Nanomaterials Science, Bohdan Khmelnytsky National University, 18031 Cherkasy, Ukraine; Department of Physics and Astronomy, Uppsala University, 752 36 Uppsala, Sweden. Electronic address: bfmin43@ukr.net.
Department of Physics and Astronomy, Uppsala University, 752 36 Uppsala, Sweden.
Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012 China. Electronic address: yanbing@jlu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125704.
Absorption spectra of PS in the ultraviolet and infrared region.

15 khordad Educational Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Department of Biology, Faculty of Science, Yazd University, Yazd, Iran.
Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Department of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. Electronic address: jmajidpoor@gmail.com.
Department of Biological Sciences, University of Kurdistan, Sanandaj, Iran.
Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: p.farnia@sbmu.ac.ir.
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: sajadnajafi1990@yahoo.com.
Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mosenaghaei123@gmail.com.
Corrigendum to MicroRNA-206 in human cancer: Mechanistic and clinical perspectives [Cellular Signalling, volume 101, Article 110525].

Research Group in Alzheimer Disease, Instituto de Investigación Sanitaria La Fe, Valencia, Spain; Cathedra DeCo MICOF-CEU UCH, University Cardenal Herrera-CEU, Valencia 46115, Spain.
Cathedra DeCo MICOF-CEU UCH, University Cardenal Herrera-CEU, Valencia 46115, Spain; Department of Pharmacy, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia 46115, Spain.
Research Group in Alzheimer Disease, Instituto de Investigación Sanitaria La Fe, Valencia, Spain. Electronic address: m.consuelo.chafer@uv.es.
Embedded Systems and Artificial Intelligence Group, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia 46115, Spain. Electronic address: juaparal@uchceu.es.
Response to letter to the editor: Expanding perspectives on the relationship between statin potency and lipophilicity in Alzheimer's disease management.

Department of Clinical Pharmacy, Xiangtan Central Hospital (The affiliated hospital of Hunan university), Xiangtan 411100, China; State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, School of Biomedical Sciences, Hunan University, Changsha 410082, China.
Department of Clinical Pharmacy, Xiangtan Central Hospital (The affiliated hospital of Hunan university), Xiangtan 411100, China.
Department of Clinical Pharmacy, Xiangtan Central Hospital (The affiliated hospital of Hunan university), Xiangtan 411100, China. Electronic address: xiaocanlcyx@163.com.
Expanding perspectives on the relationship between statin potency and lipophilicity in Alzheimer's disease management.

Atomic Force Microscopy (AFM) nanoindentation is the most effective method for determining the mechanical properties of soft biological materials and biomaterials at the nanoscale, with significant applications in many areas, including cancer diagnosis. However, a major drawback of this method is the complexity of the experimental procedure and data processing, which requires several calibration steps.To avoid this complexity, the AFM tip is usually approximated as a perfect cone. In this case, F=ch2, where F is the applied force, ℎ is the indentation depth, and c is a constant that depends on both the cone's half-angle and the material's properties. However, since AFM tips are pyramidal with a rounded tip apex (or similar to a truncated cone in some cases), the conical approximation may lead to non-negligible errors. Although equations exist that relate the applied force, indentation depth, and the sample's Young's modulus for real indenters, they are rarely used because they do not directly relate the applied force to the indentation depth (i.e., the fitting process is much more complicated compared to the conical approximation). In this paper, a new, accurate, simplified approach for data processing is proposed, based on fitting the force-indentation data to a quadratic equation of the form: F=c2h2+c1h. It is proven that the parameter c2 is independent of the tip apex properties. On the other hand, the parameter c1 depends on the material properties, the cone's half angle, and the shape and dimensions of the tip apex. Simulated force-indentation data from sphero-conical and blunted pyramidal indenters, along with real experimental data from lung tissues, are processed using the proposed approach. The key result is that Young's modulus can be accurately determined using only the c2 parameter; therefore, tip characterization can be avoided.
Copyright © 2025 Elsevier Ltd. All rights reserved.
School of Sciences, European University Cyprus, Nicosia 2404, Cyprus; Department of Engineering and Construction, Metropolitan College, Athens 15125, Greece. Electronic address: skontomaris@mitropolitiko.edu.gr.
Radar Systems and Remote Sensing Lab of School of Electrical & Computer Engineering of National Technical University of Athens, Athens 15773 , Greece.
School of Sciences, European University Cyprus, Nicosia 2404, Cyprus. Electronic address: an.stylianou@euc.ac.cy.
Development of an accurate simplified approach for data processing in AFM indentation experiments.

State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xian Nong Tan Street, Beijing 100050, China; Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xian Nong Tan Street, Beijing 100050, China; Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China. Electronic address: wangq1998@aliyun.com.
State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xian Nong Tan Street, Beijing 100050, China; Department of Occupational and Environmental Health, School of Public Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China. Electronic address: danzhang@imm.ac.cn.
Corrigendum to Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons [Brain Res. Bull. 154 (2020) 32-42].

7,7'-Diazaisoindigos are π-conjugated compounds but with poor luminescence properties. Their poor luminescence is generally attributed to the twisting around the central C7-C7' bond in the excited state which favors non-radiative decay. We have found an unusual high fluorescence quantum yield (ΦF ≈ 15 %) in a N,N‑Octyl-7,7'-diazaisoindigo derivative incorporating two triphenylamine (TPA) subunits at 5,5'-positions (called compound 12). There are very few examples of fluorescent 7,7'-diazaisoindigos have been reported and the emission mechanism is generally associated by the hindering of the rotation around the central C7-C7' bond. Unexpectedly, 12 also experiences a twisting around the central C7-C7' bond in the excited state but is highly emissive. The intense fluorescence emission of 12 was attributed to the coexistence of two TPA-7-azaoxindole subunits acting as two fluorophores into a single molecule. The fluorescence emission of 12 is also sensitive to the polarity of the solvent. The intramolecular charge transfer character of the excited state was studied combining spectroscopic and theoretical methods.
Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, 28805 Alcalá de Henares, Madrid, Spain.
Instituto de Ciencia de Materiales de Madrid (ICMM), CSIC, Cantoblanco, 28049 Madrid, Spain.
Departamento de Química Física, Facultad de Farmacia, Universidad de Castilla-La Mancha, C/ José María Sánchez Ibañez s/n, 02071 Albacete, Spain. Electronic address: andres.garzon@uclm.es.
Instituto de Ciencia de Materiales de Madrid (ICMM), CSIC, Cantoblanco, 28049 Madrid, Spain; Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, 28805 Alcalá de Henares, Madrid, Spain. Electronic address: emgfrutos@icmm.csic.es.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125699.
Unusual high fluorescence of a 7,7'-diazaisoindigo derivative: A photophysical study.

Analyzing manure nutrients such as total ammonium nitrogen (NH+4), dry matter (DM), calcium oxide (CaO), total nitrogen (-N), phosphorus pentoxide (P2O5), magnesium oxide (MgO), and potassium oxide (K2O) helps in fulfilling crop nutritional needs while improving the profitability and a lower risk of pollutants. This study used two Near Infra Red (NIR) spectral datasets of fresh and dried manure. The freshly prepared NH4Cl, CaO, Ca(OH)2, P2O5, MgO, and K2O samples were used for spectral signature peak identification and calibration. The pre-processing methods, Savitzky-Golay (SG), Multiplicative Scatter Correction (MSC) and Standard Normal Variate (SNV), were applied to correct the spectra and PCA to reduce the dimension of these pre-processed spectra. Several regressors and classifiers with wrapper multioutput regression algorithms (WMRA) and stacking generalization models were applied to identify the chemical contents. In the regression analysis, the WMRA achieved the highest coefficient of determination (R2) of 0.983 and RPD of 7.68 for fresh manure, while R2 of 0.949 and RPD of 4.42 for dried manure. In classification analysis, k-nearest neighbors (KNN) achieved 100.0% highest accuracy, while 98.1% 5-fold average accuracy. The overall findings of this study indicate that NIR, in conjunction with WMRA and KNN, has a high potential for quick detection of nutrients in manure.
Goa College of Pharmacy, Panaji, Goa 403001, India.
School of Chemical Sciences, Goa University, Taleigao Plateau, Goa 403206, India.
School of Chemical Sciences, Goa University, Taleigao Plateau, Goa 403206, India. Electronic address: pranay@unigoa.ac.in.
School of Physical and Applied Sciences, Goa University, Taleigao Plateau, Goa 403206, India. Electronic address: madhusudan@unigoa.ac.in.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125697.
Artificial intelligence with wrapper multioutput regression to identify chemical contents of fresh and dried manure samples using NIR spectroscopy.

Self-assembly plays a crucial role in the formation and allosteric processes of many biomolecules, water molecules can affect these processes. Cytosine (Cyt) has excellent self-assembly ability, forming a flat and ordered structure through hydrogen bonds (HBs) in the presence of water molecules. However, the vibration dynamics and interaction mechanism of water induced Cyt self-assembly are still unclear. In this work, infrared spectroscopy techniques, combined with density functional theory (DFT) theoretical calculations, were employed to investigate the vibrational characteristics and interactions of water molecule mediated self-assembly of Cyt and its reverse process. The results indicate that the induction of Cyt self-assembly by water molecules has differential effects on the various vibrational modes of the Cyt molecule. Multi-view infrared spectroscopy provides a powerful tool for the characterization of biomolecules in situ. This study will contribute to a deeper understanding and application of nucleic acid biological nanostructures.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210 China; University of Chinese Academy of Sciences, Beijing 100049 China.
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210 China. Electronic address: zhuzj@sari.ac.cn.
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210 China.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 China.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210 China. Electronic address: zhaohw@sari.ac.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125708.
Water-mediated cytosine self-assembly in infrared perspective.

To determine the association between adherence to positive airway pressure and healthcare costs among a national sample of older adults with comorbid OSA and common chronic conditions.Our data source was a random sample of Medicare administrative claims for years 2016-2019. Inclusion criteria included age >65 years and new diagnosis of OSA. Exclusion criteria included evidence of prior OSA treatment during the 12 months prior to the index date, active cancer, or end-stage renal disease. OSA was defined using physician-assigned diagnostic codes. Common chronic conditions included chronic obstructive pulmonary disease, congestive heart failure, depression, hypertension, type 2 diabetes mellitus, obesity, and stroke. Based on Medicare policy, individuals were classified as adherers, non-adherers, or non-initiators. Risk adjustment was based on the CMS-HCC approach developed by the Centers for Medicaid and Medicare Service specifically to estimate anticipated costs. To examine the impact of PAP adherence on costs, we employed a weighted DID regression framework to account for baseline variations in health status and other confounding factors.Participants included 28,220 Medicare beneficiaries with comorbid OSA. Of these, 45% were adherent to PAP, 10% were non-adherent, and 44% did not initiate PAP. Relative to non-initiators, beneficiaries who initiated PAP displayed $195 reduced per-member per-month costs over 24 months. This finding remained consistent across all seven medical and psychiatric subgroups, as well as among individuals with multimorbidity.In this national analysis of Medicare beneficiaries with common chronic conditions, PAP adherence was associated with reduced costs over 24 months.
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Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Santa Barbara Actuaries Inc., Santa Barbara, CA, USA.
EnsoData, Madison, WI, USA.Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Santa Barbara Actuaries Inc., Santa Barbara, CA, USA.Department of Statistics & Applied Probability, University of California, Santa Barbara, CA, USA.
Association Between Positive Airway Pressure Therapy and Healthcare Costs Among Older Adults with Comorbid Obstructive Sleep Apnea and Common Chronic Conditions: An Actuarial Analysis.

Model P-chirogenic phosphonates derived from isopinocampheol, offering an excellent experimental system for studying chirality on the phosphorus chiral center, were studied using a set of chiroptical methods including ECD, VCD and ROA. Thanks to their rigidity, limiting the number of possible conformers, we successfully correlated the experimental UV-vis/ECD, IR/VCD and Raman/ROA results with DFT calculations. This allowed us to confidently assign the absolute configuration of our models, and our assignment is consistent with X-ray diffraction (XRD) data. Furthermore, we identified phosphorus-related signals in chiroptical spectra. Specifically, the low frequency P-involving bending modes, which are only visible in ROA spectra and well-reproduced by calculations, may play a key role in determining the stereochemistry of the phosphorus chiral center. These findings lay a solid foundation for further investigation of P-chirogenic compounds, including more complex systems, using chiroptical methods, particularly ROA.
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic. Electronic address: marketa.pazderkova@uochb.cas.cz.
University of Chemistry and Technology, Faculty of Chemical Engineering, 166 28 Prague, Czech Republic.
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic; University of Chemistry and Technology, Faculty of Chemical Technology, 166 28 Prague, Czech Republic.
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic.
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 160 00 Prague, Czech Republic. Electronic address: prochazkova@uochb.cas.cz.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125674.
Chiroptical spectroscopy complemented by quantum chemical calculations accurately predicts the absolute configuration of P-chirogenic compounds.

Luminescence of NaLaMgWO6 doped with lanthanide activators Tb3+, Eu3+ and Er3+ are reported. These activators exhibit characteristic emission spectra. Either the emission colour or the excitation spectrum distinguishes between these activators. This fact can be exploited for anti-counterfeit applications. Results demonstrating the applications are presented. The luminescent markers using Tb3+ and Eu3+ phosphors are seen as green and red under illumination by 275 nm and 315 nm light emitting diodes, respectively. Combination of Eu3+ and Er3+ can also be used. In this case the markers are seen as red and green under illumination by 315 nm and 375 nm light emitting diodes, respectively.
IHLR & SS, Department of Physics, Anand Niketan College of Science, Arts & Commerce, Warora 442907 India. Electronic address: pusdekarashvini2407@gmail.com.
IHLR & SS, Department of Physics, Anand Niketan College of Science, Arts & Commerce, Warora 442907 India. Electronic address: nileshugemuge@gmail.com.
Sri Guru Tegh Bahadur Khalsa College, Jabalpur, India.
Department of Physics, RTM Nagpur University, Nagpur 440033 India.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125714.
Lanthanides doped NaLaMgWO6 phosphors for anti-counterfeit applications.

The construction of helical structures through self-assembly and the exploration of their formation mechanisms not only amplify chiroptical properties but also provide profound insights into the structures and functions of natural helices. In this study, we developed a chiral Au(I) system based on BINAP and alkynyl ligands. The modification of the length or number of alkyl chains at the terminal positions of the alkynyl ligands significantly impacted the self-assembly behavior of the complexes. Complexes (S)/(R)-2, (S)/(R)-3, (S)/(R)-5, and (S)/(R)-6 demonstrated aggregation-induced circularly polarized luminescence (AICPL). Notably, complexes (S)-6 and (R)-6 were capable of self-assembling into highly ordered helical aggregates, resulting in amplified glum values reaching an order of magnitude of 10-2. The unique double-helix stacking observed in the crystal structure of (R)-6 provided a plausible explanation for the formation of such helical aggregates. This research offers a strategy for achieving amplified CPL through artificial helices, providing new insights and guidance for the development of Au(I) complexes with CPL activity.
State Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, PR China.
State Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, PR China. Electronic address: chshliu@mail.ccnu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125719.
Chiral alkynyl Au(I) complexes: Enhancing chiroptical amplification of circularly polarized luminescence through supramolecular helices.

A zinc(II) coordination polymer, [Zn(H2dhtp)(2,2'-bpy)(H2O)]n (1), has been utilized as a dual-mode luminescence-colorimetric sensor (H2dhtp2- = 2,5-dihydroxy terephthalate and 2,2'-bpy = 2,2'-bipyridine). The presence of hydroxyl groups in H2dhtp2- can promote excited-state intra- and intermolecular proton transfer (ESIPT) phenomena. Therefore, compound 1, which displays high stability in aqueous environments, exhibits a strong green-yellow photoluminescence. This luminescence signal can be considerably enhanced and blue-shifted upon the addition of Al3+ ions with a limit of detection (LOD) of 0.15 μM, and it demonstrates significant resistance to interference from several competing metal ions. To demonstrate a practical application, 1@paper strips were fabricated that can visually detect the Al3+ ion under a UV lamp. Moreover, 1 can detect either Fe2+ or Fe3+ ions in aqueous solutions by a visible color shift. Upon the incremental addition of Fe2+ or Fe3+ ions, the solution color changed from colorless to pink, exhibiting a pronounced absorption band at around 521 nm. The LODs were determined to be 1.55 and 0.34 μM for Fe2+ and Fe3+, respectively. Furthermore, compound 1 was used for the determination of Fe3+ ions in the real water samples, which can be evaluated on-site in real-time via a smartphone color-scanning application. The detection efficacy of 1 toward Al3+ and Fe2+/Fe3+ maintains significant luminescence stability and reusability.
Materials Chemistry Research Center, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002 Thailand.
Materials Chemistry Research Center, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002 Thailand. Electronic address: jaursup@kku.ac.th.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125729.
Dual-mode luminescence and colorimetric sensing for Al3+ and Fe2+/Fe3+ ions in water using a zinc coordination polymer.

Among the numerous measurements carried out during a well-logging procedure, the Nuclear Magnetic Resonance (NMR) assessment is one of the fundamental analyses in determining the economic viability of a well for the oil industry. Nowadays, two reliable approaches, Wireline Logging (WL) and Logging While Drilling (LWD), stand out. WL comprises the acquisition of NMR data under static conditions. On the other hand, in LWD, the NMR measurements happen simultaneously with the drilling process, while the NMR tool experiences translation, rotation, and vibration motions relative to the rock formation. In order to comprehend better the NMR response acquired under LWD conditions, a setup emulating an LWD tool was developed, consisting of a single-sided magnet, rf probes, and a mechanical device that emulates a relative sinusoidal movement between the sample and the applied magnetic field. A bulk sample and three representative rocks, Fontainebleau Sandstone, Berea Sandstone, and Indiana Limestone, were investigated. Even though the diffusion coefficient measurements remain neglected for their intrinsic characteristics of data acquisition, the findings demonstrate that the diffusion coefficient parameter of a fluid in a bulk sample or confined in a porous rock can be precise and accurately predicted. In strong magnetic field gradients, the Hahn spin echo is predominantly weighted by the diffusion process, an effect used to measure diffusion coefficients. Under LWD conditions, the diffusion coefficient measurement is considerably affected by signal phase modulation due to sample movement in the presence of strong magnetic field gradients, making this measurement difficult. This article present solutions for correct diffusion coefficient measurements, synchronizing Hahn spin echo experiments with sample movement.
Copyright © 2025 Elsevier Inc. All rights reserved.
São Carlos Institute of Physics, University of São Paulo São Carlos São Paulo Brazil. Electronic address: agide@usp.br.
São Carlos Institute of Physics, University of São Paulo São Carlos São Paulo Brazil.
Leopoldo Américo Miguez de Mello Research and Development Center - CENPES/Petrobras Rio de Janeiro Rio de Janeiro Brazil.
Diffusion coefficient measurements for moving samples under strong magnetic field gradients.

Faculty of Medicine, Université Laval, Quebec City, QC, Canada; CERVO Brain Research Center, Quebec City, QC, Canada. Electronic address: andreanne.sharp@fmed.ulaval.ca.
Auditory research across time: Insights from an interdisciplinary publishing platform.

Determining the handedness of helical nanocoils using transmission electron microscopy (TEM) has traditionally been challenging due to the deep depth of field and transmission nature of TEM, complementary techniques are considered necessary and have been practiced such as low angle rotary shadowing, scanning electron microscopy (SEM), or atomic force microscopy (AFM). These methods require customized sample preparation, making direct comparison difficult. Inspired by the need to identify the helical winding direction from TEM images alone, we developed a specialized tomography grid to capture stereo-pair images, enabling stereopsis. By leveraging previous research on nano-coiled structures using identical materials and tomography grids, we successfully identified the handedness of helical coils. Our model sample consisted of graphitic nanotubes with bilayer ribbons of π-stacked hexa-peri-hexabenzocoronene (HBC) units, forming right- and left-handed helical coils from (S)- and (R)-enantiomers of the amphiphile [Jin W. et al. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 10801-10806]. Using stereo-pair TEM images, we evaluated the accuracy of our approach in visually determining the handedness of helical coils. The technique provides a valuable tool for sample inspection, screening, and assessing relative positions, including the determination of helical handedness.
Cellular and Molecular Biotechnology Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central-6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan; Electron Microscopy Facility, Open Research Facilities Station, Open Research Platform Unit, Tsukuba Innovation Arena (TIA) Central Office, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central-6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan; The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan; Departmentof Physics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi, Hamamatsu, Shizuoka 431-3192, Japan. Electronic address: n.ishii@aist.go.jp.
Health and Medical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central-6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. Electronic address: ogawa.y@aist.go.jp.
Grids designed for tomography: Stereovision transmission electron microscopy makes it easy to determine the winding handedness of helical nanocoils.

We have recorded the gas phase spectrum of isoprene at room temperature from the mid-infrared range and into the visible range (600 cm-1 to 17050 cm-1). Absorption spectra were obtained by Fourier transform infrared, conventional dispersion ultraviolet-visible-near-infrared and cavity ring-down spectroscopy to cover the entire range with a resolution comparable to that of the instruments on the James Webb Space Telescope. We have assigned the CH-stretching fundamental and overtone bands corresponding to the ΔvCH=1-6 transitions based on anharmonic vibrational calculations using normal mode and local mode models, for the lower- and higher-energy regions, respectively. We have determined accurate absolute intensities of the observed CH-stretching regions and compare with existing experimental values and with theoretical results. The accuracy of our absolute band intensity is about 2% in the fundamental region and about 10% in the 6 orders of magnitude weaker highest overtone region. Our spectrum can facilitate the detection and possibly quantification of isoprene in planetary atmospheres.
Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen Ø, DK-2100, Denmark.
Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen Ø, DK-2100, Denmark. Electronic address: hgk@chem.ku.dk.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125667.
Absorption cross section of gas phase isoprene in the infrared-visible range.

Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Plastic and Reconstructive Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.
Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: qi.fazhi@zs-hospital.sh.cn.
Corrigendum to The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment [Cellular Signalling, Volume 121 (2024), Article 111275].

Department of Medical Oncology & Institute of Women Cancers, Institut Curie, Université Paris Cité, Paris, France. Electronic address: paul.cottu@curie.fr.
European journal of cancer (Oxford, England : 1990)
Identifying and managing adverse prognosis biomarkers among advanced luminal breast cancer patients: What have we learned?

School of Medicine, China Medical University Hospital, Taichung, Taiwan.
Department of Allergy and Immunology, China Medical University Children's Hospital, Taichung, Taiwan; Research Center for Allergy, Immunology, and Microbiome (A.I.M.), China Medical University Hospital, Taichung, Taiwan; Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Electronic address: yongsuboon@gmail.com.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Landseed International Hospital, Taoyuan, Taiwan. Electronic address: yiichinyuan@gmail.com.
Department of Pediatrics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan. Electronic address: ed100616@isu.edu.tw.
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao.
Faculty of Business Administration, University of Macau, Macao.
School of Medicine and Health Management, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: Bianying@um.edu.mo.
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries.

A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy.

Department of Respiratory Medicine, Saku Central Hospital Advanced Care Center, 3400-28 Nakagomi, Saku-city, Nagano 385-0051, Japan. Electronic address: yngsw-0829@umin.org.
Department of Respiratory Medicine, Saku Central Hospital Advanced Care Center, 3400-28 Nakagomi, Saku-city, Nagano 385-0051, Japan.
Stool eosinophils and immune-related adverse event-enterocolitis.

Atomic-scale metrology in scanning transmission electron microscopy (STEM) allows to measure distances between individual atomic columns in crystals and is therefore an important aspect of their structural characterization. Furthermore, it allows to locally resolve strain in crystals and to calibrate precisely the pixel size in STEM. We present a method dedicated to the evaluation of interplanar spacing (d-spacing) based on an algorithm including curve fitting of processed high-angle annular dark-field STEM (HAADF STEM) signals. By examining simulated data of perovskite cubic SrTiO3, we confirm that our proposed method is unbiased, and the precision is better than the significant digit of the input value. Then, we study experimental data to learn how electron dose, sampling resolution, and statistical sampling affect the mean and precision values of d110. For single d-spacing measurements using a probe corrected STEM, we find that uncertainty ranges between 1 and 3 pm. Here, we measure numerous d-spacings in an automated and statistical approach, resulting in relative uncertainties in mean values ≤ 10-4. Thus, we propose to calibrate TEMs using this method as it enables measuring lattice parameters at uncertainties comparable to reports of x-ray diffraction measurements, but with a significantly lower sample volume, in this case ∼ 10-3 µm3.
Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address: akohn@tauex.tau.ac.il.
A statistical approach for interplanar spacing metrology at a relative uncertainty below 10-4 using scanning transmission electron microscopy.

University Heart Center Freiburg, Freiburg, Germany.
Department of Public Health, Vascular Surgery Unit, University Federico II of Naples, Naples, Italy.
Eur J Cardiothorac Surg. 2025-02-04;67(2):.
An advancing solution for narrow aortic pathologies in thoracoabdominal endovascular repair.

College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
School of Food Science and Bioengineering, Changsha University of Science and Technology, Hunan 410076, China. Electronic address: yiqunh@csust.edu.cn.
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Engineering Research Center of Food Thermal-Processing Technology, Shanghai 201306, China.
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Engineering Research Center of Food Thermal-Processing Technology, Shanghai 201306, China. Electronic address: kqlai@shou.edu.cn.
Effects of heat treatments, storage and reheating on volatile compounds in pork and screening for characteristic volatile compounds.

The detection of pesticide residues in agricultural products is crucial for ensuring food safety. However, traditional methods are often constrained by slow processing speeds and a restricted analytical scope. This study presents a novel method that uses filter-array-based hyperspectral imaging enhanced by a dynamic filtering demosaicking algorithm, which significantly improves the speed and accuracy of detecting pesticide residues. Our approach enhances the spatial and spectral resolution of hyperspectral images, thereby providing a rapid and cost-effective alternative to conventional methods with an image integration time of 20 ms. Tested on both synthetic datasets and real agricultural samples, this technology demonstrates superior performance under high noise conditions and exceptional precision in spectral reconstruction at critical color edges. The practicality of this system is demonstrated by integrating a hyperspectral microfilter array with a smartphone's imaging sensor, thereby showcasing the feasibility of deploying this advanced detection technology in everyday portable devices for quick and convenient monitoring of pesticide residues.
School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072 China; State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072 China.
School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072 China.
School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072 China. Electronic address: mxy1994@tju.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125703.
Rapid pesticide residues detection by portable filter-array hyperspectral imaging.

For on-site analysis, the combination of surface enhanced Raman scattering (SERS) and colorimetry, as a dual-mode detection, can effectively improve the accuracy of detection, and reduce the influence of instrument fluctuation, which greatly improves the accuracy and reliability of the results. However, the preparation of SERS/colorimetry substrates are usually time-consuming and costly, which limits their practical applications. In this paper, a hydrophobic paper-based SERS/colorimetry substrate can be prepared by a simple spraying method. The hydrophobicity is introduced by the structures formed with polydimethylsiloxane and polymethylmethacrylate, which leads to high detection sensitivity due to its enrichment effect. Moreover, the electrostatic interaction between Ag nanoparticles and the analytes further enhances the performance of SERS and colorimetry in detection of thiram and aspartame. It also provides a new method for the detection of aspartame with colorimetry. Finally, the detection limits of SERS and colorimetry for thiram and aspartame are 0.1 mg/L and 0.1 g/L, 1 mg/L and 0.1 g/L, respectively. The paper-based SERS/colorimetry substrate makes the results more reliable through dual-mode detection, which shows great potential in the detection of real samples.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: luenan@jlu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125731.
A paper-based SERS/colorimetry substrate for reliable detection.

The analysis of Raman and Infrared (IR) phonons in monolayered tetragonal (Sr, Ba)2HfO4 compounds, which exhibit D174h symmetry and belong to the I4/mmm phase of space group 139 with Z = 2, has been conducted using normal coordinates. The Sr2HfO4 and Ba2HfO4 compounds are the first members of the Ruddlesden-Popper (RP) series denoted as (Sr, Ba)n+1HfO3n+1 with n = 1. Nine Short-Range Force Constants (SRFC) have been included in theoretical calculations to analyze the optical phonons of Sr2HfO4 and Ba2HfO4 compounds within the I4/mmm phase. The assignments of optical vibrational modes in (Sr, Ba)2HfO4 compounds have been determined using Wilson's GF-Matrix Method and cross-referenced with data obtained from compounds sharing similar structural characteristics. The analysis also involved studying how the exchange of cation-A (A = Sr, Ba) impacts the lattice dynamics of the isostructural compounds A2HfO4 (A = Sr, Ba) in monolayered tetragonal structures. In this analysis, a comparison has been made between the vibrational modes at the Zone Center, the force constants, and bond lengths to assess the influence of the cation exchange. Furthermore, for each normal mode in the Ruddlesden-Popper phase (Sr, Ba)2HfO4, the examination of Potential Energy Distribution (PED) sheds light on the significant impact exerted by Short-Range Force Constants on the calculated vibrational modes, providing a deeper understanding of their behavior and interactions.
Department of Physics, School of Basic and Applied Sciences, K.R. Mangalam University, Gurugram, Haryana 122103, India; Department of Physics, Pt. Jawaharlal Nehru Govt. College, Faridabad, Haryana 121002, India.
Department of Physics, School of Basic and Applied Sciences, K.R. Mangalam University, Gurugram, Haryana 122103, India. Electronic address: ruby.jindal@krmangalam.edu.in.
Department of Physics, Deshbandhu College (University of Delhi), New Delhi 110019, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125730.
Investigation into the vibrational characteristics of monolayered ruddlesden-popper compounds (Sr, Ba)2HfO4.

HBT-DPI was a single-molecule multi-conformational fluorescent material and had unique applications for hydrophobic/hydrophilic mapping on large-scale heterogeneous surfaces. In this paper, the different proton transfer processes and luminescence mechanisms of HBT-DPI in Dichloromethane (DCM, no hydrogen bond (HB) receptor) and N, N-Dimethylformamide (DMF, HB receptor) solvents were systematically studied. Using the quantum chemistry method, the stable structures of HBT-DPI in two solvents were determined based on the Boltzmann distribution. The analysis related to HBs parameters and charge distribution confirmed the HBs strength variation and ICT properties of HBT-DPI after photoexcitation. We confirmed that HBT-DPI underwent the stepwise (A → B → C) excited state double proton transfer (ESDPT) process in DCM. Whereas, HBT-DPI underwent the excited state intramolecular proton transfer (ESIPT) process in DMF, with the weakened intramolecular hydrogen bond (IAHB) after photoexcitation. By simulating the fluorescence spectra in the two solvents, we attributed the fluorescence in the experiment of DCM to the S1 state radiation. In DMF, the fluorescence of the S1 and PT states jointly contributed to the fluorescence band at 500 nm observed in the experiment. Furthermore, the hole-electron analysis indicated that the fundamental reason for fluorescence quenching of HBT-DPI in DCM was the charge decoupling effect. Our work provided a comprehensive and systematic explanation of the different proton transfer mechanism and luminescence characteristic for HBT-DPI in two kinds of solvents. On this basis, we furnished the theoretical guidance and reference for its application in hydrophobic/hydrophilic monitoring and measurement.
Jilin Key Laboratory of Solid-State Laser Technology and Application, School of Physics, Changchun University of Science and Technology, Changchun 130022 China.
Jilin Key Laboratory of Solid-State Laser Technology and Application, School of Physics, Changchun University of Science and Technology, Changchun 130022 China. Electronic address: huili@cust.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125739.
Ingeniously regulating the conformational equilibrium and ESPT mechanism of HBT-DPI by solvent environment: A novel perspective.

The coal molecular structure in micro-areas plays a critical role in matrix thermal conduction and volatile generation during the pyrolysis of tar-rich coal. However, as a major maceral contributing to hydrocarbon generation, the molecular structures of different micro-areas in vitrinite show heterogeneity, which still lacks research. Micro-FTIR technology was used in this study to characterize the molecular structure in different micro-areas of tar-rich coal with varying tar yields. It exhibits a significant advantage in obtaining the molecular structure of the coal surface at the micrometer scale compared to transmission FTIR. The results have shown: Even within the homogeneous vitrinite under a microscope, the molecular structural heterogeneity in different micro-areas is also marked. Specifically, the functional groups in the 1100-1800 cm-1 band show a greater heterogeneity than the 2800-3000 cm-1 and 700-900 cm-1 bands. In the former, the variation of the C=C, C-O, and -CH2- contents is particularly pronounced, indicating that aromatic structures, ether bonds, and alkyl structures are the key factors leading to heterogeneity. Furthermore, samples with higher tar yields exhibit weaker molecular structural heterogeneity. The above research provides theoretical guidance for analyzing the pyrolysis behavior of tar-rich coal.
Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation, Xi'an University of Science and Technology, Xi'an 710054 China.
Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation, Xi'an University of Science and Technology, Xi'an 710054 China. Electronic address: qmshi@xust.edu.cn.
Shaanxi Coal Chemical Industry Technology Research Institute Co.,Ltd, Xi'an 710199 China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125749.
Study on molecular structural heterogeneity of tar-rich coal based on micro-FTIR.

Organic photovoltaics (OPVs) have improved greatly in recent years in pursuit for efficient and sustainable energy conversion methods. Specifically, utilizing quantum chemistry approaches such as density functional theory (DFT), the electronic structures, energy levels, and charge transport characteristics of donor-π-acceptor (D-π-A) systems based on non-fullerene donor and acceptor molecules have been examined and synthesized. Non-fullerene acceptors offer several advantages over traditional fullerene-based materials, such as enhanced light absorption, modifiable energy levels, and reduced recombination losses. Quantum mechanical simulations are helpful in the design and development of these materials because they can accurately predict the energy level alignment, molecule interactions, and charge transport properties needed for the high-efficiency of OPVs. The research begins through the selection of electron-donating and electron-accepting non-fullerene polymeric molecules using the unique properties of non-fullerene derivatives and non-fullerene acceptors. The theory uses the B3LYP-D3 method with a 6-31+G (d,p) basis set. PY-IT is used as the reference molecule, and eight molecules PY-IT01-PY-IT08, has been created by changing the end caps of the acceptor units. The created compound has superior photovoltaic characteristics. Focus has been specifically given to the frontier molecular orbitals (FMOs), natural bond order (NBO) analysis, reorganization energies (RE), and absorption spectra in order to assess the viability of charge separation and efficient light absorption. Finally, the molecular electrostatic potential (MEP) analysis, transition density matrix (TDM) analysis, and improved open circuit voltage (Voc) all have been computed. The results of the findings provide new insight to design organic solar cells (OSCs) with improved photovoltaic and solar energy conversion capabilities, which has great potential for the future development of more dependable and efficient OSCs.
Department of Chemistry, Government College University Faisalabad, Faisalabad 38000 Pakistan; Dry Lab (Janjua.XYZ), Physical Chemistry and Computational Modelling (PCCM), Department of Chemistry, Government College University Faisalabad, Faisalabad 38000 Pakistan.
Department of Chemistry, Government College University Faisalabad, Faisalabad 38000 Pakistan.
Department of Chemistry, University of Agriculture, Faisalabad 38000 Pakistan.
Harbin Normal University, Songbei Campus, Harbin 150026 China.
Department of Chemistry, College of Science, King Saud University, Riyadh 11451 Saudi Arabia.
Department of Chemistry, Government College University Faisalabad, Faisalabad 38000 Pakistan; Dry Lab (Janjua.XYZ), Physical Chemistry and Computational Modelling (PCCM), Department of Chemistry, Government College University Faisalabad, Faisalabad 38000 Pakistan. Electronic address: Janjua@gcuf.edu.pk.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125741.
Unveiling next-generation organic photovoltaics: Quantum mechanical insights into non-fullerene donor-acceptor compounds.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.Broad Institute of MIT and Harvard, Cambridge, MA, USA. fquintana@rics.bwh.harvard.edu.Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.
Intestinal microbiome metabolites control sepsis outcome.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. stephanie.xie@uhn.ca.
IRE1α-XBP1 moonlighting to restrict leukemia.

The combination of surface-enhanced Raman spectroscopy in the ultraviolet spectral region (UV-SERS) with resonance Raman scattering enhancement, referred to as UV-SERRS, enables ultrasensitive and reliable detection of biomolecules because of the strong electronic transition of many biologically important compounds in UV region. Adenine solution studies by UV-Raman spectroscopy revealed pre-resonant enhancement of various modes by 2-16 times at 325 nm excitation wavelength. Adsorption and structural properties of adenine on a cobalt electrode were probed by UV-SERS. The nanostructured cobalt electrode was prepared via electrodeposition from diluted aqueous CoSO4 solutions under negative electrode potentials. Using 325 nm excitation, potential-dependent UV-SERS spectra of adenine adsorbed on the Co electrode were obtained. Based on analysis of isotopic H2O/D2O substitution, concentration- and potential-dependent spectra, the bonding and structure of adsorbed molecule were revealed. Adenine primarily adsorbs in its N9H form, interacting with cobalt through the N7 atom of the imidazole ring and the amino group, with its ring plane nearly perpendicular to the surface. These findings highlight adenine's potential as a model for studying nucleobase-metal interactions, which is crucial for applications in biosensing, molecular electronics, and surface passivation. The study underscores cobalt's viability as a cost-effective, stable and magneto-plasmonic UV-SERS substrate, opening new avenues for the development of advanced analytical techniques.
Center for Physical Sciences and Technology (FTMC), Saulėtekio Ave. 3 LT-10257 Vilnius, Lithuania.
Center for Physical Sciences and Technology (FTMC), Saulėtekio Ave. 3 LT-10257 Vilnius, Lithuania. Electronic address: martynas.talaikis@ftmc.lt.
Center for Physical Sciences and Technology (FTMC), Saulėtekio Ave. 3 LT-10257 Vilnius, Lithuania. Electronic address: gediminas.niaura@ftmc.lt.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125733.
Electrochemical UV-SERS of adenine on cobalt electrode.

Soil nitrogen content and pH value are two pivotal factors that critically determine soil fertility and plant growth. As key indicators of soil health, they each play distinct yet complementary roles in the soil ecosystem. Nitrogen is one of the essential nutrients for plant growth, while soil pH directly influences the activity of soil microorganisms. These microbes are essential for breaking down minerals and organic materials, which in turn affects the availability and conversion of key nutrients like nitrogen and phosphorus. A comprehensive understanding of the distribution of total nitrogen content and pH value is crucial for ensuring the sustainability of agricultural production and maintaining soil and ecosystem health. Existing models for estimating soil property based on near-infrared (NIR) spectral data often overlook the spatial non-stationarity of the relationship between soil spectra and composition content. Therefore, we proposed a new model for estimating soil total nitrogen content and pH value, which combined geographically neural network weighted regression (GNNWR) with extreme gradient boosting (XGBoost), utilizing neural networks to improve the accuracy of predicting total nitrogen content and pH value, efficiently captured the spatial heterogeneity between spectral reflectance and soil total nitrogen content and pH value in different regions. Using the soil nutrient and visible near-infrared spectral samples collected by Eurostat in 2009 for the land use and coverage area frame survey of the 23 members of the European Union, the Geographically Neural Network Weighted-eXtreme Gradient Boosting (GNNW-XGBoost) model was used to estimate total nitrogen content and pH value. The spatial correlation between reflectance of spectral characteristic bands and soil total nitrogen content, pH value was trained in the model to verify its robustness and superiority, and the experimental process was improved by 10-fold cross-validation. In terms of model evaluation, compared to the standalone XGBoost and GNNWR models, the GNNW-XGBoost model demonstrated superior predictive accuracy. It achieved a highest coefficient of determination (R2) of 0.84 for total nitrogen and 0.80 for pH. Additionally, it reduced the root mean square error (RMSE) by 7.64 %, 7.61 % for total nitrogen, and 8.96 %, 4.69 % for pH, respectively. This study not only provides a new method for accurate prediction of soil total nitrogen content and pH value, but also has significant reference value for other estimation issues involving geographic data, which can help to improve the accuracy of environmental monitoring, optimize resource management strategies, and promote the development of sustainable agriculture.
College of Mathematics and Computer Science, Zhejiang A&F University, Hangzhou 311300 China; Institute of Modern Agriculture and Health Care Industry, Wencheng 325300 China; College of Engineering, China Agricultural University, Beijing 100083 China; Ministry of Agriculture and Rural Affairs, Key Laboratory of Spectroscopy Sensing, Hangzhou 310058,China.
College of Mathematics and Computer Science, Zhejiang A&F University, Hangzhou 311300 China.
China Mobile (Zhejiang) Innovation Research Institute Co., Ltd., Hangzhou 310016 China.
College of Mathematics and Computer Science, Zhejiang A&F University, Hangzhou 311300 China. Electronic address: lhao@zafu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125716.
Soil total nitrogen content and pH value estimation method considering spatial heterogeneity: Based on GNNW-XGBoost model.

The research aimed to develop of a thiabendazole-derived dual metal sensing probe (TBZT) for the selective detection of metal ions and to explore its metal complexes in reducing environmental pollutants like nitro-phenol and dyes. Absorption and emission based studies predicted the selectivity and sensitivity of TBZT towards Ni(II) and Co(II) ions which was further validated by 1HNMR, Mass, FT-IR, DFT, Docking, electrochemical, TGA studies and vibrating sample magnetometer analysis techniques. Limit of detection (LOD) values were calculated as 2 × 10-10 M and 4.17 × 10-8 M for Ni(II) metal ion in emission and absorption based techniques respectively and 2.8 × 10-9 M and 4.5 × 10-6 M for Co(II). EDTA based Reversible binding behaviour suggested its potential for constructing molecular logic gates. Catalytic studies of metal complexes of TBZT with these metals demonstrated TBZT-Co(II) superior activity in reducing nitro-phenol, rhodamine B and methyl red. Real sample analysis validated its capability for the environmental monitoring of these metal ions. This emphasized its potential application in metal ion detection and catalysis.
Department of Chemistry, Panjab University Chandigarh, 160014, India. Electronic address: gjpsingh@pu.ac.in.
Department of Chemistry, Panjab University Chandigarh, 160014, India. Electronic address: tseringg04@gmail.com.
Department of Chemistry, DAV College Chandigarh, 160011, India.
Ondokuz Mayıs University, Faculty Science, Department of Physics, 55139, Samsun, Turkey.
Ondokuz Mayıs University, Faculty Science, Department of Chemistry, 55139, Samsun, Turkey.
Department of Chemistry, Panjab University Chandigarh, 160014, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125737.
Synthesis and X-ray evaluation of 7 N-1S thiabendazole based 1,2,3-triazole as a dual metal sensing probe: Molecular logic gate construction, DFT analysis, real water sample analysis and catalytic activity investigation of its metal complexes.

Metal fluorides-multi-functional tools for the study of phosphoryl transfer enzymes, a practical guide.

Department of Urology, Chang Gung Memorial Hospital at Linkou, Taiwan; School of Medicine, Chang Gung University, Kwei-shan, Tao-Yuan, Taiwan. Electronic address: laserep@cgu.edu.tw.
School of Medicine, Chang Gung University, Kwei-shan, Tao-Yuan, Taiwan; Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taiwan.
School of Medicine, Chang Gung University, Kwei-shan, Tao-Yuan, Taiwan; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taiwan.
Mitochondrial insights on antidiabetic therapies: Differential impacts of SGLT2i, GLP-1, and insulin.

Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), Warsaw, Poland.
Institute of Evolutionary Biology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Poland.
Department of Functional and Organic Food, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), Warsaw, Poland.
Institute of Evolutionary Biology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Poland; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Department of Food Technology and Assessment, Institute of Food Sciences, Warsaw University of Life Sciences (WULS), Warsaw, Poland.
Australian Capital Territory, Canberra 2903, Australia.
Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), Warsaw, Poland. Electronic address: danuta_jaworska@sggw.edu.pl.
Corrigendum to Dry-aged beef quality with the addition of Mucor flavus - Sensory, chemosensory and fatty acid analysis [Meat Science, Volume 220, February 2025, 109691].

1550 nm-responsive upconversion luminescence (UCL) has attracted increasing attention due to its potential applicability in a new generation of bio-probes and photonic devices. However, regulating multi-color UCL with pump power remains a challenge. In this work, through constructing the coupling between Er3+ and Tm3+ ions and suppressing the energy transfer upconversion process of Er3+ ions, the response of UCL color in Gd2(MoO4)3:Er3+/Tm3+ to pump power is enhanced significantly. Upon increasing the power density from 1.33 to 68.39 W/cm2, the dominant wavelength (λD) shifts about 100 nm to the shorter wavelength region. This study provides a simple and effective strategy for color-tunable dynamic UCL.
Huzhou Key Laboratory of Materials for Energy Conversion and Storage, College of Science, Huzhou University, Huzhou 313000, China.
Huzhou Key Laboratory of Materials for Energy Conversion and Storage, College of Science, Huzhou University, Huzhou 313000, China. Electronic address: tpang@126.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125717.
Unleashing the potential of Er3+-Tm3+ coupling for the regulation of power-dependent multi-color upconversion luminescence.

The adverse effects of Al3+ ions on human health necessitate the development of ultra-sensitive detection methods for Al3+ ions. In this regard, the compact and portable design of the detection substrate is of utmost importance for achieving in-situ and sensitive detection of Al3+ ions. In our study, we have successfully developed a surface-enhanced Raman scattering (SERS) platform with gold nanoparticles (Au NPs) that was modified with histidine (His) and 4-mercaptobenzoic acid (4-MBA) for the SERS detection of Al3+ ions. His and 4-MBA molecules are attached to the Au NPs through a co-assembly strategy. His with amino and carboxyl groups imparts the Au NPs with an aggregation effect against Al3+ ions, while 4-MBA provides the SERS responsiveness. The coordination effect of Al3+ ions leads to the aggregation of Au NPs, creating hot spots around the 4-MBA molecules and thereby enhancing the SERS signals. Based on this principle, we have constructed a SERS analysis method for detecting Al3+ ions in solution. Furthermore, the paper-based plasmonic strips loaded with His-4-MBA-Au NPs have been successfully employed for the SERS detection of Al3+ ions. These strips exhibit a significantly higher enhancement factor of 9.77 × 106 compared to the solution system, thanks to the physical aggregation of the strips. The Au NPs tend to generate localized electromagnetic hot spots on the surface of strips, playing a critical role in achieving superior SERS performance. The limit of detection (LOD) of His-4-MBA-Au NPs for Al3+ detection is as low as 7.38 nM. The fabricated strips have also undergone repeatability testing and analysis of real samples. The established platform for the detection of Al3+ ions holds great promise for portable and on-the-spot analysis.
College of Chemistry, Liaoning University, Shenyang 110036, China.
Beijing BOE Display Technology Co., Ltd, China.
College of Chemistry and Life Science, Shenyang Normal University, Shenyang 110034, China.
College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address: zhangq@lnu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125742.
A portable paper-based surface enhanced Raman scattering platform for Al3+ sensing.

Cancer Center, Faculty of Health Sciences, University of Macau, Macau, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau, China.
Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Centre for Respiratory Disease, Guangzhou, China.
State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an, China.
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Department of Oncology, Kiang Wu Hospital, Macau, China. Electronic address: sumscaoyabing@hotmail.com.
Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Centre for Respiratory Disease, Guangzhou, China. Electronic address: liangwh1987@163.com.
Cancer Center, Faculty of Health Sciences, University of Macau, Macau, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau, China; State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China. Electronic address: lhleung@um.edu.mo.
Ginseng polysaccharides circumvent acquired resistance to anti-PD-1 immunotherapy in patients with non-small cell lung cancer.

The Raman spectra of lanthanide [Ln(H2O)4(Ala)2]2(ClO4)6 crystals were measured with 488, 532, 633, and 1064 nm laser lines, and ROA of complexes in water were collected using 532 nm excitation. As in IR and VCD, ν(CO) stretching and β(OCO) bending vibration bands showed a tendency typical to the lanthanide contraction effect. However, in Raman, the effect is less pronounced than the IR spectrum because it is strongly perturbed by lanthanide ion luminescence, which comes from the 4f → 4f transitions. The lower the energy of the excitation line, the less the bands are perturbed by the luminescence. On the other hand, some ROA spectra taken in water revealed strong circularly polarized luminescence signals (Eu, Sm, and Er complexes). Yet, for the non-luminescing systems, it was impossible to see lanthanide ions' influence as the signals were too slight and hidden in noise.
Laboratory for Spectroscopy, Molecular Modeling and Structure Determination, Institute of Nuclear Chemistry and Technology, 16 Dorodna Street, 03-195 Warsaw, Poland. Electronic address: e.machalska@ichtj.waw.pl.
Laboratory for Spectroscopy, Molecular Modeling and Structure Determination, Institute of Nuclear Chemistry and Technology, 16 Dorodna Street, 03-195 Warsaw, Poland. Electronic address: k.lyczko@ichtj.waw.pl.
Laboratory for Spectroscopy, Molecular Modeling and Structure Determination, Institute of Nuclear Chemistry and Technology, 16 Dorodna Street, 03-195 Warsaw, Poland. Electronic address: j.rode@ichtj.waw.pl.
Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, 14 Bobrzynskiego Street, 30-348 Krakow, Poland. Electronic address: jakub.dybas@uj.edu.pl.
Biological and Chemical Research Centre, and Faculty of Chemistry, University of Warsaw, 101 Żwirki i Wigury Street, 02-089 Warsaw, Poland. Electronic address: b.palys@uw.edu.pl.
Laboratory for Spectroscopy, Molecular Modeling and Structure Determination, Institute of Nuclear Chemistry and Technology, 16 Dorodna Street, 03-195 Warsaw, Poland. Electronic address: j.dobrowolski@ichtj.waw.pl.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125713.
Raman, ROA, and luminescence spectra of chiral lanthanide complexes with L- and D-alanine.

A new corrole derivative bearing 8-hydroxyquinoline moiety, which was labeled as 8-HQ-Corrole, serves as an efficient fluorescent probe for Mg2+ in the presence of various interferents. This probe 8-HQ-Corrole displayed an ultra-fast response (2 s) to Mg2+ with an impressive detection limit (33 nM) and a significant fluorescence enhancement, accompanying with a blue shift from 667 to 653 nm in fluorescence spectrum. MS and Job's plot analysis indicated that the enhanced fluorescence response was attributable to the formation of 1:2 stoichiometric complex between to Mg2+ and 8-HQ-Corrole involving quinoline nitrogen and oxygen atoms. Furthermore, the capability of 8-HQ-Corrole for environmental and biological application has been demonstrated in water and living Hela cells.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: luguifen@ujs.edu.cn.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125744.
A corrole-based derivative as an ultra-fast response and high selective fluorescent probe for Mg2+ and its application.

Department of Urology, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan; School of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Department of Urology, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan; School of Medicine, Chang Gung University, Taoyuan 333, Taiwan. Electronic address: laserep@cgu.edu.tw.
The interplay of aging, sleep dysregulation, and mitochondrial dysfunction in metabolic and neurodegenerative diseases.

The out-of-plane (OOP) deformations of metalloporphyrins macrocycle are closely related to their biological functions, and Raman spectroscopy is a powerful tool for investigating OOP deformations. However, due to the interplay of electronic structure, substituents, porphyrin macrocycle in-plane (IP) and OOP deformations, it is challenging to measure the OOP deformations directly, or, establish a confirmative correlation between the frequency shifts of characteristic peaks and specific OOP deformation changes. In this work, we first selected the model porphyrin Ni-P and employed DFT calculations to explore the relationship between the ruffling and saddling deformation changes and their corresponding Raman spectral differences. Subsequently, we focused on nickel meso-tetraphenyl porphyrin (NiTPP), nickel meso-tetrachlorophenylporphyrin (NiTClP), and nickel meso-tetramethoxyphenyl porphyrin (NiTMeOP), which are structurally similar in nature, and investigated the relationship between their OOP deformations and Raman spectra bands based on both experiments and DFT calculations. The results indicate that the ruffling deformation magnitudes of the three nickel porphyrins are almost identical, while the saddling deformation magnitudes differ remarkably. The frequency change of the characteristic peak γ18 in relation to saddling deformation of the three porphyrins is 7.7cm-1/Å, which is close to that of the model porphyrin Ni-P 10.6cm-1/Å. Therefore, the characteristic peak γ18 can be used as a reporter for the change in saddling deformation. As such, this work demonstrates how to utilize the frequency shifts of low-frequency Raman characteristic peaks to identify the OOP deformation changes of the porphyrin macrocycle caused by variations in the external environment, thereby providing a theoretically assisted tool for revealing the reasons for their biological function variations.
Institute of Intelligent Machines, Hefei Institute of Intelligent Agriculture, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; Science Island Branch of Graduate School, University of Science & Technology of China, Hefei 230026, China; Department of Basic Sciences, Army Academy of Artillery & Air Defense, Hefei 230031, China.
Institute of Intelligent Machines, Hefei Institute of Intelligent Agriculture, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; Science Island Branch of Graduate School, University of Science & Technology of China, Hefei 230026, China. Electronic address: huangq@ipp.ac.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125750.
Detecting the saddling deformations in nickel meso-phenyl substituted porphyrins using low-frequency Raman characteristic peaks.

Organic room-temperature phosphorescence (RTP) luminogens have showed significant potential in the fields of diagnostics, sensing, and information encryption. However, it is difficult to achieve high RTP yield (ΦP) and long RTP lifetime simultaneously. By methyl substitution, positional isomerism, and host-guest doping, three new D-π-A type luminogens named as TBTDA, 2M-TBTDA, and 3M-TBTDA were designed and synthesized, whose RTP properties were tuned and optimized. In various solvents and glassy THF solution, similar solvatochromism and phosphorescence nature of three luminogens were revealed. In poly (methyl methacrylate) (PMMA) and polyvinyl alcohol (PVA) matrixes, the luminogens showed high-contrast RTP properties. TBTDA emitted invisible afterglow in PMMA films, but with strong RTP and long green afterglow in PVA films. More importantly, 2M-TBTDA showed RTP and afterglow lifetimes of 809.81 ms and 8 s, as well as ΦP of up to 0.64 in PMMA at 1 % doping concentration. Taking advantage of Foerster resonant energy transfer (FRET), reddish-brown or orange afterglow were observed, with emission maxima of 593-617 nm, RTP and afterglow lifetimes of 299-566 ms and 5-6 s, ΦP of 0.34-0.46, as well as FRET efficiency of 70-90 %. Finally, dynamic anti-counterfeiting and digital encryption were successfully constructed via different fluorescence, RTP colors, and afterglow lifetimes. This work not only obtained an efficient host-guest doping RTP system, but also can be expected to provide more theoretical guidance and experimental supports for molecular design, dynamic anti-counterfeiting and digital encryption.
Guangxi Key Laboratory of Electrochemical and Magneto-chemical Function Materia, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China.
Tianjin International Center for Nanoparticles and Nanosystem, Tianjin University, Tianjin 300072, China.
Tianjin International Center for Nanoparticles and Nanosystem, Tianjin University, Tianjin 300072, China. Electronic address: lei.ma@tju.edu.cn.
Guangxi Key Laboratory of Electrochemical and Magneto-chemical Function Materia, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China. Electronic address: wyt_shzu@163.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125763.
Modulating room-temperature phosphorescence of D-π-A luminogens via methyl substitution, positional isomerism, and host-guest doping.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany.
Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany; Side Effect Registry Immuno-Oncology SERIO, Munich, Germany.
Department of Dermatology, Allergology and Phlebology, Hospital Bremerhaven Reinkenheide, Bremerhaven, Germany.
Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich, Germany.
Department of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany.
Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany; Dr. Philip Frost, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany; Side Effect Registry Immuno-Oncology SERIO, Munich, Germany; Department of Dermatology, University Hospital Erlangen, Erlangen, Germany. Electronic address: Lucie.Heinzerling@med.uni-muenchen.de.
Corrigendum to Persistent immune-related adverse events after cessation of checkpoint inhibitor therapy: Prevalence and impact on patients' health-related quality of life [Eur J Cancer 176 (2022) 88-99].

Knee osteoarthritis (OA) is a common degenerative musculoskeletal condition that impairs mobility and balance, increasing fall risk. When combined with osteoporosis, it further increases the risk of fragility fractures. Despite its prevalence, the frequency of knee OA in patients who have fragility hip fractures (FHFs) is not well established. This study aimed to determine the prevalence of knee OA among FHF patients.We conducted a cross-sectional analysis of patients who underwent surgical treatment for FHF. The knee OA diagnoses followed the American College of Rheumatology criteria, and severity was assessed via the Kellgren-Lawrence classification system. Bone mineral density (BMD) was evaluated at the lumbar spine and contralateral hip, and fall risk was assessed using a self-report questionnaire.Among the 162 patients who had FHF (mean age 79 ± 8.1 years; 80.2% women), 66% had symptomatic knee osteoarthritis (SKOA). Of these, 21.0% were classified as end-stage knee osteoarthritis. Notably, 47.1% of these end-stage knee osteoarthritides were recommended for knee OA surgery before their hip fracture. The presence of SKOA was significantly associated with a history of multiple falls (P = 0.013) and a high fall risk (P = 0.020). Among the 120 patients who had BMD data, 68% had low BMD (T-score ≤ -2.5) at the contralateral hip or lumbar spine. Almost half (45%) of the FHF patients had concurrent SKOA and low BMD, whereas approximately 20% had SKOA, low BMD, and a high fall risk.There is a high prevalence of SKOA among FHF patients. Comprehensive evaluation and management of knee OA and osteoporosis are essential to reduce the risk of subsequent fractures in this vulnerable population.
Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.
Faculty of Medicine Siriraj Hospital, Department of Orthopaedic Surgery, Mahidol University, Bangkok, Thailand.
High Prevalence of Symptomatic Knee Osteoarthritis Among Patients Who Have Fragility Hip Fractures.

Light-matter interaction has been profoundly studied for sample material classification. However, the optical classification of the sample through the polarized light-matter interaction remains underexplored. It is limited to the measurement of intensity instead of the angle of polarized light (AOP) for its degree of polarization. Measurement of the degree of polarization within a material or a medium becomes easier with a simple, low-cost and direct measurement without the need of any probing or labelling agent. Thus, this investigation was conducted mainly to determine the angle of polarized light (AOP) property of the crosslinked polymer using our proposed polarization measurement technique as an alternative approach of the material classification. The angle of polarized light (AOP) of each polymer was determined in combination property of polarization by absorption, transmission, and scattering. Our proposed scattered angle (ס=90°, 100°, 110°, and 120°) successfully measured the AOP of each polymer that can be classified into two groups. Group 1 represents the AOP value ( [Formula: see text] ) for a test sample of t1 = 3.1 %, 3.2, and 3.3 % with comparison to the normal sample (n = 3.0 %) and Group 2 represents the AOP value ( [Formula: see text] ) for the test sample oft2 = 3.4 %, 3.6 % and 3.7 % with comparison to the normal sample (n = 3.0 %). Our study proved a direct, easy, and simple method of determining the degree of polarization of the polymers without the need of complex formulation and labelling protocol. Therefore, this work may enhance the investigation of the optical properties of the agarose-based tissue-mimicking phantom (AGTMP) for modeling or simulation of the real biological sample in the future. Our polarization measures are worthy of further explored and implemented in current optical imaging techniques or sensing platform for optical classification of the biomaterials.
Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur 50603 Malaysia. Electronic address: aine@um.edu.my.
Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur 50603 Malaysia. Electronic address: salmah_karman@um.edu.my.
Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur 50603 Malaysia.
Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur 50603 Malaysia.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125503.
The angle of polarized light (AOP) property for optical classification of the crosslinked polymer.

We analyze the Lotka-Volterra n prey-1 predator system with no direct interspecific interaction between prey species, in which every prey species undergoes the effect of apparent competition via a single shared predator with all other prey species. We prove that the considered system necessarily has a globally asymptotically stable equilibrium, and we find the necessary and sufficient condition to determine which of feasible equilibria becomes asymptotically stable. Such an asymptotically stable equilibrium shows which prey species goes extinct or persists, and we investigate the composition of persistent prey species at the equilibrium apparent competition system. Making use of the results, we discuss the transition of apparent competition system with a persistent single shared predator through the extermination and invasion of prey species. Our results imply that the long-lasting apparent competition system with a persistent single shared predator would tend toward an implicit functional homogenization in coexisting prey species, or would transfer to a 1 prey-1 predator system in which the predator must be observed as a specialist (monophagy).
Department of Computer and Mathematical Sciences, Research Center for Pure and Applied Mathematics, Graduate School of Information Sciences, Tohoku University, Aramaki-Aza-Aoba 6-3-09, Aoba-ku, Sendai, Miyagi, 980-8579, Japan. seno.math.is@tohoku.ac.jp.
Persistent prey species in the Lotka-Volterra apparent competition system with a single shared predator.

Biodiesel is renewable energy source an alternative to conventional fossil fuels. The primary concern lies in detecting alcohol content in biodiesel, which can either be intentionally added by adulterants or remain in trace amounts from the refining process of biodiesel synthesis. In order to regulate the quality of biodiesel production, it is crucial to develop an analytical method for monitoring alcohol content in biodiesel. Present study identified Coumarin 153 (C-153) with outstanding solvatochromic characteristics in multiple biodiesel feedstocks (soybean, canola, sesame, and corn). Based on our spectroscopic investigations, this alcohol (methanol, ethanol, and propanol) sensing method has proven to be rapid, sensitive, ratiometric, and visually discernible, and the detection limit for ethanol in soybean biodiesel could reach 0.23 % v/v. The percentage of alcohol (0-100 % v/v) in the biodiesel determines significant changes in the lifetime values of the C-153 from 5.1 ns to 0.35 ns. Moreover, we depict explicit solvation models (ethanol) and implicit solvation models (biodiesel) from quantum chemical calculations to explain the experimental results. Based on our study, C-153 with alcohol sensing capabilities seems to have potential applications in biodiesel analysis. The present results will inspire future efforts to simplify and optimize the detection of alcohol in biodiesel by using optical methods.
Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502284, India.
Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502284, India. Electronic address: kgavvala@chy.iith.ac.in.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125755.
Coumarin 153, a solvatochromic fluorescent probe, for analyzing the biodiesel blends derived from various feedstocks.

Owing to its high spatial resolution and its high sensitivity to chemical element detection, transmission electron microscopy (TEM) technique enables to address high-level materials characterization of advanced technologies in the microelectronics field. TEM instruments fitted with various techniques are well-suited for assessing the local structural and chemical order of specific details. Among these techniques, 4D-STEM is suitable to estimate the strain distribution of a large field of view. This study tends to discuss the viability of using two existing commercial solutions with a low-convergence angle 4D-STEM technique and TEM-based Nanobeam Precession Electron Diffraction (N-PED) methods for strain analysis in an industrial context. In such a framework, strain measurements intend to point out the extent of defects and thus reveal a trend of the stress field, rather than to precisely estimate the absolute values of the deformations. Strain distribution maps have been obtained for AlGaN/GaN HEMT devices using two transmission electron diffraction analysis methods. The performances of 4D-STEM and Nanobeam Precession Electron Diffraction (N-PED) solution for strain mapping have been compared for both a relatively thin (≈ 55 nm) and a thick (≈ 150 nm) TEM cross section specimen. The strain maps obtained with both methods have shown comparable results for a thin sample, with the ability to characterize the deformation induced by a 1 nm-thick layer of AlN spacer grown between the AlGaN barrier and GaN channel forming the 2DEG of the HEMT device. The results presented here also illustrate the limitation of both commercial solutions in the case of a thick sample.
Copyright © 2025. Published by Elsevier Ltd.
STMicroelectronics Crolles, 850 Rue Jean-Monnet, Crolles 38926, France; CEMES-CNRS, 29 Rue Jeanne Marvig, Toulouse 31055, France.
STMicroelectronics Crolles, 850 Rue Jean-Monnet, Crolles 38926, France. Electronic address: jean-gabriel.mattei@st.com.
CEMES-CNRS, 29 Rue Jeanne Marvig, Toulouse 31055, France.
Comparative electron diffraction analysis of strain relaxation in AlxGa1-xN materials in the microelectronics industry: 4D-STEM approach vs. TEM-based N-PED solution.

In recent years, it has become a development trend to design multi-application luminescent materials with rare earth ion doping. In this work, a series of Eu3+/Sm3+ doped self-activated Na2YMg2V3O12 (NYMVO) phosphors were synthesized through a simple high-temperature solid-state reaction method. Interestingly, due to the energy transfer (ET) from the matrix to the activators, the luminescence color of the phosphors changed from turquoise to orange-red and yellow-green under near-ultraviolet (n-UV) 365 nm excitation. Based on the fluorescence intensity ratio of the matrix to Eu3+/Sm3+, the optical thermometry performances of the NYMVO:0.20Eu3+ and NYMVO:0.06Sm3+ phosphors were described. Notably, the maximum absolute sensitivity (Sa) values for NYMVO:0.20Eu3+ and NYMVO:0.06Sm3+ phosphors were 0.30 K-1 and 0.032 K-1, respectively. Correspondingly, the maximum relative sensitivity (Sr) values were 2.17 %K-1 and 1.22 %K-1, respectively. Moreover, the light-emitting devices based on NYMVO:0.20Eu3+ and NYMVO:0.06Sm3+ phosphors had excellent optical properties, with correlated color temperature (CCT) of 4552 K and 4470 K, and color-rendering index (CRI) of 84.6 and 88.5. These results suggested that the two vanadate phosphors prepared had potential applications in both warm white light-emitting diodes (WLEDs) and optical thermometry.
College of Chemical and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022 China.
College of Chemical and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022 China. Electronic address: liuguixia22@163.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125759.
Tunable luminescence in Eu3+/Sm3+ doped Na2YMg2V3O12 for WLEDs and optical thermometry.

College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Yuelushan Laboratory, Changsha 410128, China.
Yuelushan Laboratory, Changsha 410128, China; College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Yuelushan Laboratory, Changsha 410128, China; College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Yuelushan Laboratory, Changsha 410128, China. Electronic address: wanfc@sina.com.
Corrigendum to High leucine bioavailability improves beef quality by altering serum metabolism in beef cattle [Meat Science volume 220 (2025) 109693].

Faculty of Medicine, Afghanistan Center for Epidemiological Studies, Herat, Afghanistan.Faculty of Medicine, Ghalib University, Herat, Afghanistan.
Clinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India.
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Department of Paediatrics, Dr D. Y. Patil Medical College Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Maharashtra, India.Department of Public Health Dentistry, Dr D. Y. Patil Medical College Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Maharashtra, India.
Improving evidence certainty in aortic arch replacement outcomes.

Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. fergusonst@niaid.nih.gov.
Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
NIAID workshop on infections and autoimmune diseases.

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan and TUM Center for Infection prevention (ZIP), Technical University of Munich (TUM), Freising, Germany. anna.schulz@tum.de.Onkologisches Zentrum Freising MVZ GmbH, Freising, Germany. anna.schulz@tum.de.
Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan and TUM Center for Infection prevention (ZIP), Technical University of Munich (TUM), Freising, Germany.

Amiens, France. Electronic address: braillon.alain@gmail.com.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Re: 'The relative effectiveness of a high-dose quadrivalent influenza vaccine versus standard-dose quadrivalent influenza vaccines in older adults in France: a retrospective cohort study during the 2021-2022 influenza season' by Bricout et al.

The following paper is centred on an analysis of comparative studies of the human pelvis developed over the 19th century by mostly French natural scientists, physical anthropologists, students of the human anatomy and doctors engaged in the initial stages of the emerging fields of gynaecology and obstetrics. As this paper will argue, there was considerable overlap between these specialisations, producing a fundamentally masculine, Eurocentric and racialised knowledge that had an enormous impact in establishing racially informed gynaecological and obstetric practices. This paper argues that comparative pelvic anatomy studies originated from the belief that African and Black women had specifically different pelves and genitalia and served to stratify women of different races and promoted racially oriented obstetric and gynaecological treatments. Despite their European origins, these French publications had profound repercussions across various regions of the Atlantic world and directly influenced the medical care provided to women of African descent in both slave and postemancipation societies, particularly in Brazil. In 1887, a doctoral candidate from the Rio de Janeiro Medical School (Brazil) wrote a dissertation in which he advocated and justified the racialised treatments offered to enslaved, free and soon-to-be-free women of African descendent who delivered their offspring at the medical school's maternity ward. In his advocacy for such practices, the author drew connections between the prevailing methods at Rio de Janeiro's Medical School to a long lineage of French medical thought on the racialised comparative anatomy of women's pelvises throughout the 19th century.
© Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
History, Universidade de São Paulo, São Paulo, São Paulo, Brazil hmachado@usp.br.
On the consequences of childbirth: obstetrics/gynaecology, comparative anatomy and racial theories in 19th century France and Brazil.

Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update.

Servicio de Medicina Interna, Hospital Universitario La Paz; IdiPAZ Instituto de Investigación, Hospital Universitario La Paz, Madrid, España. Electronic address: alejandro.diez@salud.madrid.org.
Superficial vein thrombosis: A complex entity with understimated risk.

The infarcted heart is energetically compromised exhibiting a deficient production of adenosine triphosphate (ATP) and the ensuing impaired contractile function. Short-term blockade of the protein S100A9 improves cardiac performance in mice after myocardial infarction (MI). The implications upon ATP production during this process are not known.This study evaluates whether S100A9 blockade effects ATP synthesis and cardiac contractility in C57BL/6 mice at seven days post-MI.Three experimental groups were used: (i) mice with MI, induced by permanent left coronary ligation, (ii) mice with MI, short-term treated with the S100A9 blocker ABR-238901, and (iii) sham (control) mice. After removing the left ventricle, mass spectrometry, pathway enrichment analysis, Western blot, RT-PCR and pharmacological network analysis were performed.A number of 600 differentially abundant proteins (DAPs) was significantly altered by the S100A9 blocker in MI-treated mice compared with MI mice. Some of these proteins were associated with oxidative phosphorylation, citrate cycle (TCA), mitochondrial fatty acid beta-oxidation, glycolysis and cardiac muscle contraction pathways. In the ischemic ventricle, ABR-238901 treatment increased (1.8- to 38-fold) the abundance of proteins NDUFAB1, UQCRC1, HADHA, ACAA2, ALDOA, PKM1, DLD, DLAT, PDHX, ACO2, IDH3A, FH1, CKM, CKMT2, TNNC1, crucial for early cellular metabolic changes, ATP distribution and contractility. The cardiac level of ATP increased (1.8-fold, p < 0.05) in MI mice treated with ABR-238901 compared to MI mice. The network pharmacology analysis uncovered potential pharmacologic targets of ABR-238901 that may interact with DAPs related to ATP production and contractility.Short-term S100A9 blockade effectively regulates the proteins implicated in ATP production and cardiac contractility post-MI, providing a framework for future cardiac energy metabolism studies.
Proteomics Department, Institute of Cellular Biology and Pathology Nicolae Simionescu of the Romanian Academy, Bucharest, Romania.
Department of Pathophysiology, University of Medicine Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania.
Department of Pathophysiology, University of Medicine Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania; Department of Clinical Sciences Malmö, Lund University, Sweden.
Proteomics Department, Institute of Cellular Biology and Pathology Nicolae Simionescu of the Romanian Academy, Bucharest, Romania. Electronic address: felicia.antohe@icbp.ro.
Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction.

Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Gastroenterology, Center for Immune-Related Diseases at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. bingsu@sjtu.edu.cn.Department of Gastroenterology, Center for Immune-Related Diseases at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. bingsu@sjtu.edu.cn.Department of Oncology at Xiangya Cancer Center and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. bingsu@sjtu.edu.cn.Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism (SYIIM), Shanghai Jiao Tong University School of Medicine, Shanghai, China. bingsu@sjtu.edu.cn.
Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity.

Evasion of T cell responses by newly emerging SARS-CoV-2 variants.

Department of Pharmacy, Center for Translational Research in Cancer, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China; Department of Respiratory Critical Care, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
School of pharmacy, Chengdu Medical College, Chengdu, China.
Department of Pharmacy, Center for Translational Research in Cancer, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Department of Ultrasound, Center for Translational Research in Cancer, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Department of Respiratory Critical Care, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address: lzhlyyhy@126.com.
Department of Ultrasound, Center for Translational Research in Cancer, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. Electronic address: graceof@163.com.
Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: wangqiuju@scszlyy.org.cn.
Erratum to the 'Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment' Pharmacol. Res. 210 (December) (2024) 107539.

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation.

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine and UPMC Heart and Vascular Institute, Pittsburgh, PA, USA.
Passing the learning curve in robotic mitral valve repair-what do we know in 2025?

Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.Center for Infectious Diseases Prevention, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. m.c.nawijn@umcg.nl.GRIAC research institute, University Medical Center Groningen, Groningen, the Netherlands. m.c.nawijn@umcg.nl.
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa.

Single-cell profiling of the immune landscape across the human lifespan.

This work represents a comprehensive study of the ground vibrational state of C-13 substituted methanol using very high-resolution far-infrared (FIR) and infrared (IR) Synchrotron Radiation spectra recorded with a very high signal-to-noise (S/N) ratio in the entire region from 40to5000cm-1, at the Canadian Light sources. High resolution combined with a high S/N ratio allowed the recording to be done with an unprecedented resolution of about 0.0017cm-1. The peak of the unblended spectral lines could be obtained with an estimated accuracy of ±5kHz. The torsional vibrational states have been analyzed in the first five torsional states (n = 0,1…4). Assignments have been obtained for K- values up to about 15 and J- values of about 35 for the three symmetry species (A,E1,andE2). Assignments below 40cm-1 were obtained from the earlier spectra at a lower resolution. The assigned transition line wave numbers were directly fitted to the term values of the quantum states involved. A significant perturbation has been seen in the spectra later associated with the intensity borrowing effects, resulting in forbidden transitions with ΔK as high as ±7. Coriolis interactions have analyzed the perturbations observed in various states. The assignments have been confirmed using closed combination loops and the term values obtained for a given state derived from different sharing transitions. The most exciting phenomenon observed is the finding of torsional overtone transitions. These overtone transitions include the first, second, and third overtones (n=2←0,3←0,and4←0) and their hot torsional counterparts, e.g., transitions starting from excited torsional states (3←1,4←1,and4←2). These overtone transitions become possible due to the anharmonicity of the potential well due to internal rotation. The overtone transitions also include many forbidden transitions. About 19,000 lines have been assigned and included in determining accurate term values. A detailed 6th-order Hamiltonian and the various aspects of torsion-rotation-vibration distortion effects are discussed, including the asymmetry effects. A global Hamiltonian analysis, including all the excited torsional state transitions, was seen to diverge. However, a reduced data set of about 9,000 lines with lines up to the second excited states revealed reasonable Hamiltonian parameters, which adds some confidence to the present analysis. The pure torsional energies have been obtained in more direct observations up to the 4th torsional excited states. Most of the data and some relevant parts of the spectrum have been moved to three Appendices: I, II, and III. They are being submitted as supplementary material to conserve journal space. This work represents the most complete study of the ground vibrational state of this crucial interstellar methanol species. This work should help the detection of this molecular species in the interstellar space.
Department of Physics and Engineering, Albany State University, GA 31707. USA. Electronic address: indra.mukhopa@outlook.com.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125600.
A comprehensive study of the ground vibrational state of the C-13 substituted methanol using high-resolution Synchrotron radiation spectra: Perturbation, forbidden, torsional fundamental overtone, excited overtones, and hot overtones transitions.

Renal dysfunction is significantly associated with poor prognosis in patients with heart failure. However, the prognostic significance of proteinuria as a potential marker of an impaired glomerular filtration barrier in acute heart failure (AHF) remains unclear. We aimed to investigate the prognostic value of urinary protein/creatinine ratio (PCR) in patients with AHF.Urinary protein levels measured at admission were adjusted for urinary creatinine concentrations in 346 patients (75 ± 13 years; 61 % men) with AHF. Patients were categorized based on urinary PCR, adhering to the Japanese chronic kidney disease (CKD) guideline cut-offs for CKD staging: A1 (<0.15 g/gCr), A2 (0.15-0.49 g/gCr), and A3 (≥0.5 g/gCr). The primary endpoint was all-cause mortality.Overall, there were 85, 126, and 135 patients in the A1, A2, and A3 groups, respectively. Groups A2 and A3 were associated with lower hemoglobin levels, higher blood urea nitrogen and N-terminal pro-B-type natriuretic peptide levels, and poor renal function. Moreover, groups A2 and A3 had high cystatin C, alpha 1 microglobulin, and urinary liver-type fatty acid-binding protein (L-FABP) levels. Urinary PCR correlated more with tubular markers, alpha 1-microglobulin, and L-FABP than with the glomerular marker cystatin C. Over a median follow-up period of 434 (interquartile range: 89-753) days, 72 deaths occurred. Elevated urinary PCR was associated with higher mortality rates (log-rank test, p < 0.001), even after adjusting for other variables [A2 vs. A1: hazard ratio (HR) 2.59, 95 % confidence interval (CI) 0.71-9,55, p = 0.15; A3 vs. A1: HR 4.40, 95 % CI 1.17-16.6, p = 0.029].Elevated urinary PCR is more prevalent in patients with AHF and is associated with a higher risk of all-cause mortality, independent of covariates, including glomerular function. Thus, urinary PCR at admission should provide prognostic information independent of glomerular function.
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: yuya8950@gmail.com.
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo, Japan.
Prognostic values of proteinuria in patients with acute heart failure.

There is an increase in the variation of family forms, types of parenthood roles and methods for family formation. One way of family building has most recently been referred to as 'elective co-parenting'. Yet, many other terms and somewhat diverging concept definitions have been put forward. This paper aims to establish a fundamental conceptual framework.We will adhere to a tailored set of guidelines for conceptual ethics organised in four stages: (i) Using a minimal scoping review of published definitions potential attributes are identified, (ii) The potential attributes are organised by theme in order to identify any necessary and sufficient or shared ones, (iii) A conceptual definition of the concept is developed, (iv) The most fitting concept label is determined.Current terminology lacks comprehensiveness and often contains additional (hidden) meanings, thereby jeopardising its usability for research on contemporary family formation. We suggest a new nomenclature.We suggest PACT (Pre-conception Agreement-based Co-parenting Together-apart) instead of 'elective co-parenting' (or equivalents) as a new concept label for this particular family type, whereby at least two parties of co-parents have agreed before the conception of a child to share parenting of this child. A party can refer either to an individual or a set of romantically involved individuals. Although there may be different types of loving relationships between some (or all) co-parents within this constellation, there is at least some 'detachment' that is recognised as being created and present by an absence of romantic love between those parties.
Bioethics Institute Ghent, Department of Philosophy and Moral Sciences, Ghent University, Ghent, Belgium.
Research Institute Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands.
Journal of reproductive and infant psychology
J Reprod Infant Psychol. 2025-01-31;():1-21.
Redefining elective co-parenting as PACT: a systematic assessment of published concepts and definitions.

Nature Immunology, . ioana.staicu@us.nature.com.

Nature Immunology, . stephanie.houston@us.nature.com.

Nature Immunology, . nick.bernard@nature.com.

Nature Immunology, . l.dempsey@us.nature.com.

Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. kalpana.manthiram@nih.gov.
Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
A symphony of immunity to SARS-CoV-2 in the adenoids.

This study presents an investigation into the electron beam damage phenomenon of Co3O4 under transmission electron microscopy (TEM). It was found that after irradiation at a dose rate of 6.78 × 106 e/nm2s, Co3O4 crystals exhibited surface reconstruction and faceting features. Electron energy loss spectroscopy (EELS) analysis indicates that the damage process initiates with the desorption of oxygen anions, which subsequently leads to a reduction in the valence state of cobalt cations and corresponding atomic rearrangement. High resolution TEM (HRTEM) reveals that surface faceting, which has an epitaxial relationship with the bulk, could help maintain the crystal lattice of face-centered cubic (fcc) Co3O4 despite Co-O bond breakage upon beam exposure. With a finely focused electron beam, the hole drilling effect was observed. The structural degradation is proposed to arise from inelastic damage that induced partial desorption of oxygen anions and rearrangement of valence-reduced cobalt cations to epitaxially grow on the surface, suggesting an interplay between irradiation damage and material restructuring. The relative phase stability of Co3O4, combined with its interfacial structure developed upon irradiation, are beneficial to magnetic loss and interfacial polarization loss, thereby rendering Co3O4 a promising candidate as an effective EMW absorber.
Instrumental Analysis and Research Center, Sun Yat-sen University, Guangzhou 510275, China.
Guangzhou Laboratory, Guangzhou 510005, China.
Instrumental Analysis and Research Center, Sun Yat-sen University, Guangzhou 510275, China; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Instrumental Analysis and Research Center, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: liangchl@mail.sysu.edu.cn.
Transmission electron microscopy analysis of Co3O4 degradation induced by electron irradiation.

Brain microbiome: is it all in our heads?

Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Promoting women in cardiothoracic surgery: when women are in, everyone wins!

Crop straws provide substantial biomass resources that are transformable for sustainable biofuels and valuable bioproducts. However, the natural lignocellulose recalcitrance results in an expensive biomass process and secondary waste liberation. As lignin is a major recalcitrant factor, genetic engineering of lignin biosynthesis is increasingly being implemented in bioenergy crops, but much remains unclear about the desired lignocellulose alteration and resulting function.This study attempted to explore the mechanisms of lignin modification responsible for efficient lignocellulose conversion in vitro and an effective plant anti-oxidation response in vivo.We initially selected specific rice mutants by performing modern CRISPR/cas9 editing with caffeic acid O-methyltransferase involved in the synthetic pathways of monolignols (G, S) and ferulic acid (FA), and then explored lignocellulose conversion and plant cadmium (Cd) accumulation using advanced chemical, biochemical and thermal-chemical analyses.Notable lignin modification was achieved from the predominately synergistic down-regulation of S-monomer synthesis in three mutants. This consequently upgraded lignocellulose porosity by up to 1.8 folds to account for significantly enhanced biomass saccharification and bioethanol production by 20 %-26 % relative to the wild-type. The modified lignin also favors the dissection of diverse lignin nanoparticles with dimensions reduced by 1.5-1.9 folds, applicable for thermal-chemical conversion into the carbon quantum dots with increased yields by 15 % and 31 %. The proportions of G-monomers and FA were significantly increased in the mutants, and the lignin extractions were further assayed with higher activities for two standard antioxidants (DPPH and ABTS) in vitro compared to the wild-type, revealing a distinctively enhanced plant antioxidative capacity in the mutants. Water culture showed that young mutant seedlings accumulated more Cd than wild-type did (p < 0.01, n = 3), suggesting effective heavy metal phytoremediation in the mutants.A hypothetical model of characteristic lignin modification for specific S-monomer reduction, accountable for improved lignocellulose recalcitrance, was proposed. It provides a powerful strategy for achieving high-yield biofuels and value-added bioproducts or enhancing plant antioxidative capacity for heavy metal phytoremediation.
Key Laboratory of Fermentation Engineering (Ministry of Education), National 111 Center for Cellular Regulation & Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China; College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, China.
College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, China.
Shandong Provincial Key Laboratory of Energy Genetics, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy & Bioprocess Technology, Chinese Academy of Sciences, Shandong Energy Institute, Qingdao New Energy Shandong Laboratory, Qingdao 266101, China.
Key Laboratory of Fermentation Engineering (Ministry of Education), National 111 Center for Cellular Regulation & Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China.
Center for Renewable Carbon, School of Natural Resources, University of Tennessee-Knoxville, Knoxville, TN 37996, United States.
College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, China; State Key Laboratory for Conservation & Utilization of Subtropical Agro-Bioresources, College of Agriculture, Guangxi University, Nanning 530004, China. Electronic address: lqwang@gxu.edu.cn.
Key Laboratory of Fermentation Engineering (Ministry of Education), National 111 Center for Cellular Regulation & Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China; College of Plant Science & Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: lpeng@mail.hzau.edu.cn.
A functional cascading of lignin modification via repression of caffeic acid O-methyltransferase for bioproduction and anti-oxidation in rice.

Department of Clinical and Experimental Medicine, Urologic Section, University of Messina, Messina, Italy.Department of Oncology, Urologic section, AOU G. Martino, Messina, Italy.
Department of Oncology, Urologic section, AOU G. Martino, Messina, Italy. gab.sorce@gmail.com.
Department of Human and Pediatric Pathology Gaetano Barresi , Pathology Section, University of Messina, Messina, Italy.
Department of Pathology, Urology, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Urology, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
Prostate Cancer Prostatic Dis. 2025-02-07;():.
A Visual Standardized (ViSta) map integrating imaging (MRI), biopsy findings and Specimen Prostate Cancer location.

Asparagus racemosus Willd., a significant medicinal plant in India's Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of the aerial part of Asparagus racemosus Willd. utilizing a streptozotocin-nicotinamide-induced diabetic rat model. The methanolic extract of plant (ARME) was evaluated for in vitro antidiabetic activity through α-glucosidase and α-amylase enzyme suppression assay and assessed in vivo in a streptozotocin-induced rat model. A 21-day chronic multiple-dose study of ARME was examined. STZ-induced diabetic rats were treated with metformin (70 mg/kg) and ARME at concentrations of 200 and 400 mg/kg. It was discovered that ARME inhibited the activities of α-amylase and α-glucosidase and showed potent therapeutic effects on the rat's model. ARME helps raise body weight, hemoglobin, and other blood counts and normalizes the serum parameters in the diabetic group. In addition, liver tissues' abnormal levels of the antioxidant enzymes glutathione and lipid peroxides were returned to those of control animals. HPTLC study revealed the presence of stigmasterol, which showed a strong affinity for the proteins linked to diabetes mellitus through in silico study. As a result of these findings, ARME inhibits the activity of digestive enzymes and has antioxidant and antihyperglycemic effects in STZ-nicotinamide-induced diabetic rats.
© 2025 Walter de Gruyter GmbH, Berlin/Boston.
Department of Pharmaceutical Technology, 30189 University of North Bengal , Darjeeling, 734013, West Bengal, India.Department of Pharmaceutical Technology, Brainware University Barasat, Kolkata, 700125, West Bengal, India.
Department of Pharmaceutical Technology, 30189 University of North Bengal , Darjeeling, 734013, West Bengal, India.
Department of Zoology, Cell and Molecular Biology Laboratory, University of North Bengal, Darjeeling, 734013, West Bengal, India.

Department of Botany, Magadh University, Bodhgaya, 824234, India.

Zeitschrift fur Naturforschung. C, Journal of biosciences
Z Naturforsch C J Biosci. 2025-02-10;():.
Antidiabetic activities of aerial part of Asparagus racemosus Willd. extract: an in vitro, in vivo, and in silico approach.

Chronic kidney disease (CKD) is a global health issue, with renal fibrosis being a common pathway in CKD development. Histone modification plays crucial roles in transcriptional regulation, but their pathological functions and mechanisms in CKD are not well understood.We utilized chromatin immunoprecipitation with next-generation DNA sequencing (ChIP-seq) and RNA-seq to evaluate the states and functions of H3 lysine 27 acetylation (H3K27ac) and H3 lysine 4 trimethylation (H3K4me3) in kidney of CKD mice. We identified epigenetic factors regulating H3K27ac through motif analysis. Expression of activating transcription factor 3 (ATF3) in CKD mouse models and patients' kidneys was validated via immunofluorescence staining or Western blot. We further generated the Atf3 deficient (Atf3-/-) mice to explore its effect in kidney function and fibrosis. ChIP-seq of H3K27ac from Atf3-/- CKD mice was employed to validate ATF3's regulatory effects. We explored how ATF3 maintains the state of H3K27ac by integrating the data sources from multiple databases.The states of H3K27ac and H3K4me3 were changed during CKD, and positively correlated with differential gene expression. ATF3 was highly expressed in kidney of both patients and mice with CKD, and co-localized with H3K27ac in genome, epigenetically regulating H3K27ac state. Atf3 deficient in CKD mice significantly ameliorated kidney dysfunction and fibrotic phenotype, and reduced H3K27ac levels at the ATF3 binding sites. Mechanically, ATF3 may recruit the histone acetyltransferases (HATs) network to maintain the H3K27ac state during CKD.ATF3 promotes kidney injury and fibrosis in CKD by maintaining the state of H3k27ac via recruiting HATs network.
Copyright © 2025 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.
Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Biomedical Big Data Center, West China Hospital, Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan 610041,China.
Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Biomedical Big Data Center, West China Hospital, Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan 610041,China.
Transcription factor ATF3 aggravates kidney fibrosis by maintaining the state of histone H3 lysine 27 acetylation.
Invasive species present significant management challenges worldwide due to their ability to rapidly adapt to novel environments. The Pacific oyster Crassostrea gigas, a globally distributed invasive species, arrived in western Sweden in 2006 but has not yet colonised the low salinity waters of the Baltic Sea, presumably because low salinities act as a barrier to reproduction. We used classic mating designs to investigate fertilisation rates and heritability of embryonal salinity tolerance (in 8‰-33‰) in oysters from three locations with different invasion history and salinity (established, 33‰; past invasion front, 23.5‰; and present invasion front, 16‰). We found that fertilisation rates at lower salinities increased with proximity to the range front, with a pronounced heritable component. We then used whole-genome sequencing of oysters from the present invasion front to identify genomic regions showing stronger deviations from Mendelian inheritance in larval full-sib families reared in low salinity compared to controls. These regions contained coding sequences for Histones and ribosomal DNA, with the paternal genotype explaining a significant proportion of the deviation, suggesting the involvement of sperm in modulation of low-salinity tolerance at fertilisation and early development. Furthermore, we found no evidence of recent bottlenecks along the invasion front. We conclude that the Pacific oyster has developed low-salinity tolerant reproductive phenotypes at the present invasion front through acclimation and natural selection. Given the strong heritability for tolerance to low-salinities at fertilisation, the species likely has the potential to adapt further to low-salinity conditions and may invade the Baltic Sea.
© 2025 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd.
Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden.Nofima AS, Tromsø, Norway.Centre for Marine Evolutionary Biology (CeMEB), Göteborg, Sweden.
Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden.Centre for Marine Evolutionary Biology (CeMEB), Göteborg, Sweden.
Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden.
Department of Biological and Environmental Sciences, University of Gothenburg, Göteborg, Sweden.Gothenburg Global Biodiversity Centre (GGBC), Göteborg, Sweden.
Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden.Centre for Marine Evolutionary Biology (CeMEB), Göteborg, Sweden.Department of Biological and Environmental Sciences, University of Gothenburg, Göteborg, Sweden.Gothenburg Global Biodiversity Centre (GGBC), Göteborg, Sweden.
The Roles of Plasticity and Selection in Rapid Phenotypic Changes at the Pacific Oyster Invasion Front in Europe.
This retrospective cohort study across 77 pediatric practices in Massachusetts assessed the frequency of CXR utilization among children with pneumonia diagnosed in the primary care setting and determined whether CXR utilization was associated with differences in antibiotic treatment and outcomes. Multivariable logistic regression was used to evaluate the association between CXR performance and future clinic revisit, CXR performance, antibiotic change, and a composite treatment failure outcome, adjusting for markers of illness severity. Among 29 528 children treated for pneumonia, 2462 (10.1%) had a CXR performed. CXR utilization varied by practice (range 0%-75% [IQR 2.7%-16.5%]). The odds of a composite outcome of treatment failure did not differ between children who had a CXR performed and those who did not (aOR 1.06; 95% CI [0.68, 1.65]). CXR was performed in the minority of patients diagnosed with pneumonia. Children who had a CXR performed had similar outcomes to those treated for pneumonia without CXR.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.Division of Emergency Medicine, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.Pediatric Physicians' Organization at Children's, Wellesley, MA, USA.
Pediatric Physicians' Organization at Children's, Wellesley, MA, USA.
Chest Radiograph Utilization Among Children Treated for Pneumonia in a Primary Care Network.
In end-stage-kidney-disease (ESKD) hyperphosphatemia occurs secondary to decreased renal elimination with continued intestinal absorption of dietary phosphate. Even in chronic kidney disease, glomerular filtration rate lower than 30 ml/min markedly decreases the filtration of inorganic phosphate and increases its serum level. Sevelamer, a non-calcium phosphate binder, is commonly used to control hyperphosphatemia. Available in two forms- sevelamer hydrochloride and sevelamer carbonate, it absorbs phosphate in the gastrointestinal tract and is known to have minimal adverse effects. These are limited to nausea, vomiting, flatulence, and metabolic acidosis, with infrequent significant adverse outcomes. We present a series of two patients with ESKD on sevelamer, with lower gastrointestinal bleeding and endoscopic findings of colonic mucosal injuries with histopathologic findings of sevelamer crystals deposition. Though reported in gastrology literature, nephrology reports show a paucity of discussion around this increasingly common adverse effect and the need for vigilance in ESKD.
Copyright © 2025. Published by Elsevier Inc.
University of Arkansas for Medical Sciences, Little Rock, Arkansas.
College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Primary Care Physician, Menoufia University, Egypt.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Gastrointestinal mucosal cell injury caused by sevelamer crystals- Case series and literature review.
To determine whether family members of pediatric surgical patients who filled a discharge opioid prescription would have higher rates of new opioid prescription fills compared with family members of patients who did not fill a pediatric surgical discharge opioid prescription.Using OptumLabs Data Warehouse administrative claims, we performed a retrospective cohort study of pediatric surgery patients aged 5 through18 and their family members, based on whether an opioid prescription for the child was filled after surgery. Neither patients nor family members had any history of prior opioid use. We calculated the frequency of new opioids filled among family members in the 12 months following the date of surgery. We created a hierarchical logistic regression model to determine the association between having a discharge opioid prescription filled for a pediatric surgical patient and a new opioid prescription filled by family members within the same household.There were a total of 206,598 family members within 76,569 households in our study. 73.75% of pediatric surgery patients had a prescription filled after surgery, resulting in 151,693 total family members within 56,456 households exposed to a new discharge opioid prescription. 7.3% of exposed family members and 19.6% exposed households then filled a new opioid prescription within 12 months, compared with 5.2% of family members and 13.3% of households (p<0.001 for both) unexposed to a filled opioid prescription after pediatric surgical discharge . After adjusting for demographic factors, clinical attributes, and surgical factors, we found an increased risk of new opioid prescription fills among exposed family members compared with unexposed family members (OR 1.28 [95% CI 1.217, 1.352, p<0.001]).Introducing a discharge opioid prescription after pediatric surgery to an opioid-naïve household is associated with increased rates of opioid prescriptions in opioid-naïve family members in the year following surgery.
Department of Anesthesia and Perioperative Care, University of California, San Francisco. Electronic address: Erica.Langnas@ucsf.edu.
Department of Anesthesia and Perioperative Care, University of California, San Francisco.
Philip R. Lee Institute for Health Policy Studies at the University of California, San Francisco.
Department of Clinical Pharmacy, University of California, San Francisco.
Department of Anesthesiology, University of Michigan; Opioid Prescribing Engagement Network, Institute for Healthcare Policy and Innovation, University of Michigan.
Department of Surgery, University of California, San Francisco.
Department of Anesthesia and Perioperative Care, University of California, San Francisco; Philip R. Lee Institute for Health Policy Studies at the University of California, San Francisco.
The Association of Opioid Prescriptions to Children after Discharge from Surgery and New Opioid Prescription Fills in Family Members.
Department of Elementary School Teacher Education, Universitas Sebelas Maret, Surakarta, Indonesia.
Disability and rehabilitation. Assistive technology
Disabil Rehabil Assist Technol. 2025-02-07;():1-2.
Bridging gaps in technology adoption for disabilities.
Although up to 89% of autistic children experience feeding difficulties, little is known about the impact of these difficulties on mealtime participation. The aim of this study was to explore the impact of feeding difficulties on the mealtime participation of autistic children and their families based on caregiver experiences.Participants were 78 caregivers who completed online surveys for 80 children (5-12 years) with a formal diagnosis of Autism Spectrum Disorder (ASD). The online survey contained eight open-ended questions exploring how children participated in mealtimes at home, in the community, at celebrations, on holidays, and at school; as well as exploring cultural influences on mealtimes.Using thematic analysis, three themes were identified: 1) Participation at home, emphasised the individualised nature of experiences and impacts for children and families, while 2) participation in the community, highlighted the range of contexts in which children and families experience challenges. 3) Influence and experience, accounted for cultural and social factors that mediated the child and family's impacts and experience, including a lack of understanding in the community.The findings highlight that autistic children with feeding difficulties and their families may experience a range of mealtime participation challenges. Caregivers also reported feelings of failure, stress, and judgement; some of which stemmed from interactions with extended family, friends, school, and society which increased their difficulties when navigating mealtime participation. Addressing the challenges requires a strengths-based approach including creating inclusive and accessible community environments that accommodate diverse feeding preferences and support the well-being of neurodivergent children and their families.
Griffith University, Southport, Australia.
Children's Health Queensland Hospital and Health Service, South Brisbane, Australia.The University of Queensland, St Lucia, Brisbane, Australia.
The Royal Children's Hospital, Parkville, Melbourne, Australia.The University of Melbourne, Victoria, Australia.School of Health Sciences, Griffith University, Gold Coast, Australia.
Menzies Health Institute Queensland, Griffith University, Southport, Australia, and.CliniKids, Telethon Kids Institute, Subiaco, Australia.
International journal of speech-language pathology
Int J Speech Lang Pathol. 2025-02-07;():1-11.
Caregiver perspectives regarding the impact of feeding difficulties on mealtime participation for primary school-aged autistic children and their families.
Pediatric Infectious Diseases, Faculty of Medicine, Cukurova University, adana, Turkey.
Department of Pediatric Surgery, Cukurova University Faculty of Medicine, Adana, Turkey.
Pediatric Hematology and Oncology, Acibadem University, Istanbul, Turkey.
Department of Radiology, Van Baskale State Hospital, Van, Turkey.
Department of Pathology, Cukurova University Faculty of Medicine, Adana, Turkey.
Pediatric Infectious Disease, Antalya Training and Research Hospital, Antalya, Turkey.
Correction: Pulmonary Hydatid Cyst and Aspergillus Coexistence in a Child with Acute Leukemia: a Rare Case Report.
The electronic states of monochlorogermene (HGeCl) are computed by using the explicitly correlated internally contracted multireference configuration interaction (icMRCI-F12) method with Davidson correction. A total of 23 spin-free states with energy up to 9.4 eV as well as 55 spin-orbit coupled states generated by these spin-free states after considering the spin-orbit coupling (SOC) effect are investigated. The geometries and harmonic vibrational frequencies of the lowest electronic states are calculated, and the spectroscopic constants, oscillator strength, vertical transition energy and potential energy curves (PECs) of the spin-free states and spin-coupled states are presented. Based on the calculation of the electronic states, the photodissociation dynamics in the ultraviolet region is discussed. Our studies will shed light on the electronic structure and decomposition processes of HGeCl radicals.
Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China.
Faculty of Information Technology, Jilin Agricultural University, Changchun 130118, China.
Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China. Electronic address: xiazhang@jlu.edu.cn.
Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China. Electronic address: xuhf@jlu.edu.cn.
Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China. Electronic address: yanbing@jlu.edu.cn.
Spectrochim Acta A Mol Biomol Spectrosc. 2025-04-05;330():125622.
Exploring the structure and photodissociation mechanism of the electronic states of monochlorogermylene including the spin-orbit-coupling.
The classic psychedelic psilocybin has attracted special interest across clinical and non-clinical settings as a potential tool for mental health. Despite increasing attention to challenging psychedelic experiences, few studies have explored the relevance of shame-related processes with psychedelic use. This prospective, longitudinal study involved sequential, automated, web-based surveys that collected data from 679 adults planning to use psilocybin in naturalistic settings at timepoints before and after psilocybin use. State and trait shame and feelings of guilt were collected using validated measures and assessed alongside other measurements of psychological health. Acute feelings of shame or guilt during psilocybin experiences were commonly reported (68.2% of users) and difficult to predict. Ratings of participant ability to constructively work through these feelings predicted wellbeing 2-4 weeks after psilocybin use. Psilocybin on average produced a small but significant decrease in trait shame that was maintained 2-3 months after use (Cohen's dz = 0.37). Trait shame increased in a notable minority of participants (29.8%). The activation of self-conscious emotions with psychedelics deserves further attention as a challenging experience subcategory that may be relevant to psychological outcomes. Such experiences could pose a unique and context-dependent learning condition for both therapeutic and detrimental forms of shame-related memory reconsolidation.
Ethical Legal Implications of Psychedelics in Society Program, Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA.Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.Sattva Medicine, Psychiatry, Psychotherapy, and Consulting Practice, Miami, FL, USA.
Center for Psychedelic Medicine, Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.Center for Psychedelic Drug Research and Education, College of Social Work, The Ohio State University, Columbus, OH, USA.
Center for Psychedelic Psychotherapy and Trauma Research, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.Center of Excellence in Psilocybin Research and Treatment, Sheppard Pratt, Towson, MD, USA.
Unlimited Sciences, Colorado Springs, CO, USA.
Shame, Guilt and Psychedelic Experience: Results from a Prospective, Longitudinal Survey of Real-World Psilocybin Use.
This technical note introduces the first open surgical conversion after a failed branched endovascular repair of a thoracoabdominal aortic aneurysm, using the new hybrid Thoracoflo device. This innovative technique reduces reno-visceral ischemia time and can be performed through a xipho-pubic laparotomy without the need for extracorporeal circulation. It offers a safe and effective solution for complex thoracoabdominal aortic diseases, and can also serve as a bailout option following endovascular failure.
Department for Vascular Medicine, Vascular Surgery-Angiology-Endovascular Therapy, German Aortic Centre Hamburg, University Heart & Vascular Centre, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Department for Vascular Surgery, Medical University Innsbruck, Innsbruck, Austria.
Department for Anaesthesiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
Open Conversion After Branched Endovascular Aortic Repair With a Novel Hybrid Graft.
Correction to: Central sensitization in axial spondyloarthritis: An explorative study with quantitative sensory testing and clinical scales.
Noise-induced hearing loss (NIHL) is among the most poorly treated diseases due to irreversible damage to hair cells. Reactive oxygen species contribute to NIHL pathogenesis by injuring the inner ear hair cells. Teriparatide (PTH1-34) exerts antioxidant properties in the context of osteoporosis. Thus, in the current study, a multifunctional thermosensitive nanodelivery system is developed, based on the unique anatomical structure of the inner ear, to load and sustain the release of PTH1-34 to alleviate hair cell damage. LR27-a fusion peptide-is assembled from a targeting peptide (A665) and cell-penetrating peptide (Arg8) to target hair cells and increase the round window membrane permeability. In vitro, the antioxidant and anti-apoptotic properties of the nanodelivery system are assessed after treating HEI-OC1 cells and cochlear explants with hydrogen peroxide to simulate the oxidative environment. In vivo, injection of the nanodelivery system into the auditory bulb protects the hearing and hair cells of an NIHL mouse model. These results demonstrate the synergistic effects of multiple peptides in treating NIHL and their potential clinical applications.
© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Department of Pathology and Laboratory Medicine, the Medical University of South Carolina, Charleston, 29425, USA.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise-Induced Hearing Loss Therapy.
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Beacon Dermatology, Calgary, AB, Canada.
Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Division of Pediatric Dermatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Journal of cutaneous medicine and surgery
Exploring the Coexistence of Turner Syndrome and Alopecia Areata: A Scoping Review.
Investigating how stroke healthcare professionals manage suicidality in stroke patients with and without aphasia.A cross-sectional survey of 981 professionals in Sweden was conducted.Nearly 60% of respondents had encountered suicidality in stroke patients without aphasia, while 40% had encountered it in patients with aphasia. SLPs were more likely to meet patients with aphasia and suicidality. Routine screening was rare, while 40% reported that suicidality was assessed when needed. Psychologists, physicians, and social workers were seen as responsible for assessments, with 13% of respondents feeling it was their responsibility to assess suicidality. Less than half of those felt competent to assess patients with aphasia. Aphasia was viewed as a barrier to assessment. Uncertainty was widespread regarding intervention, particularly in patients with aphasia, and there were concerns about the competence to handle such cases when referred to psychiatry. Free-text responses highlighted a perceived lack of competence, tools, and routine procedures for handling suicidality in aphasia, alongside calls for more mental health professionals and better interprofessional collaboration regarding suicidality in stroke rehabilitation.Management of suicidality in stroke patients, particularly with aphasia, is surrounded by uncertainty. Greater competence in suicidality, aphasia-friendly communication, and improved interdisciplinary efforts are needed.
Department of Public Health and Caring Sciences, Speech-Language Pathology, Uppsala University, Sweden.
Department of Public Health and Caring Sciences, Speech-Language Pathology, Uppsala University, Sweden.Neurologic and Geriatric Rehabilitation, Uppsala University Hospital, Uppsala, Sweden.
Routine screening for suicidality in Swedish stroke care seems to be uncommon and may need to be increased to meet recommendations from research.Aphasia is perceived to be a barrier to assessment and intervention for suicidality, possibly leading to suicidality going unnoticed in this group.Competence in both suicidality and aphasia-friendly communication strategies should be improved in stroke care and rehabilitation.In order to provide adequate care, better access to mental health professionals in stroke rehabilitation, as well as improved interdisciplinary collaboration, are needed.
Management of suicidality in stroke patients with and without aphasia-a national survey among healthcare professionals in Sweden.
Universidad de Extremadura, Badajoz, Spain.
Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
A Distinct Genetic Signature Differentiates Inflamed and Noninflamed Fibrotic Tissues in Eosinophilic Esophagitis Patients.
Children and young people (CYP) with long-term health conditions (LTC) are at higher risk of developing mental health difficulties. Research suggests nature-based therapeutic interventions (NBTIs) may benefit CYP's wellbeing, but less is known about the impact on CYP with LTC. This study's objective was to explore how CYP with LTC and associated psychological difficulties experienced a NBTI and the impact on their wellbeing. Ten participants aged 10-13 attended a NBTI and took part in semi-structured interviews that explored how they made sense of their journey through the intervention, its impact on mental, physical wellbeing and sense of self. An interpretative phenomenological analysis of the interview data yielded four group experiential themes: 'Overcoming Illness-Identity', 'Freedom to Choose', 'Sense of Connection' and 'A Mindful Presence'. Participants reported improved self-esteem, a deepened sense of belonging with peers and nature, and enhanced emotion regulation. Clinical implications and directions for future research are discussed.
Canterbury Christ Church University, UK.St Ann's Hospital, UK.
Canterbury Christ Church University, UK.
An interpretative phenomenological analysis of the experience of a nature-based therapy intervention for children with long-term health conditions and associated psychological difficulties.
Changes in climate may cause changes in the ranges, phenology and interactions of insects with other species and lead parasites to switch host species. A study of louse (flat) flies in the United Kingdom, Republic of Ireland and Isle of Man, in which licensed bird ringers acting as citizen scientists collected ectoparasites that left birds during ringing, showed recent range shifts of several species. The Common or Bird Louse Fly Ornithomya avicularia (Linnaeus, 1758), a vector of Haemoproteus sp. and trypanosomes, has undergone a major northwards range expansion of over 300 km in the United Kingdom (UK) since the 1960s. The Finch Louse Fly Ornithomya fringillina (Curtis, 1836) has also expanded its range over 300 km northwards and 400 km westwards into the Island of Ireland, and the Swallow Louse Fly Ornithomya biloba (Dufour, 1827) is now established in Wales and Southern England. The Grouse Louse Fly Ornithomya chloropus (Bergroth, 1901) has undergone a range contraction at lower altitudes and on the southern edge of its range. Other species of louse fly were detected: Crataerina pallida (Latreille, 1812), Stenepteryx hirundinis (Linnaeus, 1758), Pseudolynchia garzettae (Rondani, 1879) and Icosta minor (Bigot, 1858). Some generalist species have shifted their phenology, whereas the more specialist nest parasites of migrant birds have not, as the arrival and breeding dates of their hosts have not changed. The range changes of the generalist species of these ectoparasites may have implications for bird health, especially if they switch to new host species as their ranges shift.
© 2025 The Author(s). Medical and Veterinary Entomology published by John Wiley & Sons Ltd on behalf of Royal Entomological Society.
Edward Grey Institute of Field Ornithology, Department of Biology, University of Oxford, Oxford, UK.
Citizen scientists mapping the United Kingdom's and Republic of Ireland's flat flies (louse flies) (Diptera: Hippoboscidae) reveal a vector's range shift.
Professor (emeritus) University of British Columbia.
Management of Xylella fastidiosa subsp. pauca (Xfp) presents significant challenges due to the lack of genetic resistance in major crops, pathogen variability and resistance development against the main antimicrobial compounds, and the lack of effective chemical compounds for control. Traditional bactericides in the EU are restricted, and copper-based products are increasingly limited due to environmental impacts. In this study the antibacterial side effects of some commercial fertilizers against Xfp were evaluated. These products, containing metal ions (mainly copper and/or zinc) complexed with phosphites and bioavailable silicon, show antimicrobial and bactericidal activities in vitro which suggest their possible use to control the pathogen, as well as enhanced plant resistance to biotic and abiotic stresses. Greenhouse and open field trials showed that they can significantly reduce disease severity and pathogen population, thus improving fruit yield. The integrated pest and disease management (IPDM) strategy, which combines these treatments with agronomic and phytosanitary vector-control measures, leads to a reduction of disease symptoms in treated plants compared to untreated ones. These findings highlight the potential of systemic fertilizers to mitigate Xfp symptoms by providing antimicrobial collateral effects and probably enhance plant defenses, since similar compounds are known to be plant defense inducers in other pathosystems. Therefore, these products offer a sustainable solution for managing plant pathogenic bacteria and improving crop health and yield. This approach is crucial for the sustainability of olive production in Xf-affected areas. However, further research is needed to optimize these strategies for long-term effectiveness under field conditions. Overall, the results emphasize the value of the collateral effects of some mineral fertilizers in a comprehensive strategy aimed at mitigating the symptoms of Xfp and safeguarding the agricultural productivity as well as the invaluable heritage of centuries-old Apulian olive trees.
Institute for Sustainable Plant Protection National Research Council, Bari, Italy; carmine.delgrosso@cnr.it.
Institute for Sustainable Plant Protection National Research Council, Bari, Italy; maria.saponari@cnr.it.
Institute for Sustainable Plant Protection National Research Council, Bari, Italy; pasquale.saldarelli@cnr.it.
University of Molise, Agricultural, Environmental and Food Sciences, Campobasso, Campobasso, Italy; davide.palmieri@unimol.it.
1 Centre of Research, Experimentation and Training in Agriculture (CRSFA) Basile Caramia, via Cisternino 281, Locorotondo, 70010 Bari, Italy, Locorotondo, Italy; giuseppealtamura@crsfa.it.
Institute for Sustainable Plant Protection National Research Council, Bari, Italy; raied.aboukubaa@ipsp.cnr.it.
University of Molise, Agricultural, Environmental and Food Sciences, Via De Sanctis, snc, Campobasso, Campobasso, Italy, 86100; decurtis@unimol.it.
University of Molise, Agricultural, Environmental and Food Sciences, Campobasso, Campobasso, Italy; lima@unimol.it.
Use of commercial fertilizers in an IPDM protocol to mitigate Olive Quick Decline Syndrome caused by Xylella fastidiosa subsp. pauca in Southern Italy.
Hyaloperonospora brassicae, the causal pathogen of downy mildew, presents significant challenges to spring mix greens production in California. Genetic resistance provides a strategy for sustainable management to reduce downy mildew infections and pesticide use in organic and conventional production systems. This study aimed to identify sources of downy mildew resistance to facilitate resistance breeding in baby kale. To achieve this, three host resistance screenings were conducted to assess the resistance of baby kale accessions against eight downy mildew isolates collected from eight distinct locations on the Central Coast of California. Artificial inoculation was performed by spraying a sporangia suspension onto baby kale plants, which were then incubated in a humidity chamber. Disease severity was assessed by examining both surfaces of each leaf for chlorotic and necrotic symptoms and sporulation and then quantified using an established rating scale. Screening of all 212 accessions revealed an average disease severity of 28%, with severities ranging from 0 to 100%. The initial subset screening showed average disease severities ranging from 2.2 to 9.4% depending on the isolate. The final subset screening demonstrated a range of 0.003 to 0.072% average disease severity among the four isolates, with 13 accessions exhibiting 100% estimated resistance probability, 11 accessions between 99.0 and 99.9%, and one accession below 99.0%. These results suggested that downy mildew could be effectively managed in baby kale through resistant varieties.
California Polytechnic State University, Plant Sciences, San Luis Obispo, California, United States; elockepa@calpoly.edu.
California Polytechnic State University, San Luis Obispo, California, United States; mferna36@calpoly.edu.
California Polytechnic State University, Plant Sciences, San Luis Obispo, California, United States; kdas01@calpoly.edu.
Vilmorin-Mikado USA, Gilroy, California, United States; kyle.brasier@vilmorinmikado.com.
Vilmorin-Mikado USA, Gilroy, California, United States; charlie.dowling@vilmorinmikado.com.
California Polytechnic State University, Plant Sciences, San Luis Obispo, California, United States; sding01@calpoly.edu.
Host Resistance Screening of Baby Kale Against Downy Mildew Isolates Across the Central Coast of California.
TRANSITION is a structured behavioral and educational program to support young adults with mental, behavioral, and neurodevelopmental conditions transitioning into adulthood. This study investigated its feasibility as an add-on to regular daily living support in social services.A non-randomized single-arm mixed method design was used. Twenty-eight service users, aged 19-29, were enrolled to participate in the program for 20 weeks alongside their support workers. They rated their engagement and satisfaction and reported any adverse effects. Eighteen support workers received training in the program. A subsample of service users (n = 11) and support workers (n = 9) was interviewed about their experiences. Qualitative content analysis using an abductive approach and quantitative analyses with descriptive statistics was integrated and mapped to specific feasibility areas in a joint display.Service users completing the study (n = 26) generally rated satisfaction and engagement highly. While some service users experienced stress related to their participation, no serious adverse events were reported. Service users and support workers highlighted the program's clear structure and focus on specific goals as particularly valuable.The results indicate that TRANSITION is a feasible complement to regular support in social service settings. Further evaluation of the program is justified.Implications for rehabilitationThe TRANSITION program is a feasible add-on to regular support in daily living for young adults with mental, behavioral, and neurodevelopmental conditions.Support workers can deliver the program, although training, practice, and regular supervision are needed.Service users perceive that the program adds clarity and valued direction to their support.The program may help service users and support workers become more aware of the inherent benefits of user engagement in daily living support.
Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.
Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.Department of Medical Sciences, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden.
Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.Child and Adolescent Psychiatry, Stockholm Health Care Services, Stockholm, Sweden.
Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.Habilitation and Health, Stockholm, Sweden.
Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.Child and Adolescent Psychiatry, Stockholm Health Care Services, Stockholm, Sweden.Autism Research Group, Curtin School of Allied Health, Curtin University, Perth, Australia.
Department of Women's and Children's Health, Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.Department of Medical Sciences, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden.Child and Adolescent Psychiatry, Stockholm Health Care Services, Stockholm, Sweden.
Feasibility of the TRANSITION program as an add-on to regular daily living support for young adults: an open mixed-methods study.
In Azerbaijan, hazelnut (Corylus avellana L.) is a crop of economical and nutritional importance. However, recent aflatoxin contamination events in hazelnut produced in Azerbaijan are posing health risks to consumers and reduce marketability. Aflatoxin and fumonisin levels were examined in hazelnuts collected at 33 farmers' stores, one month after the 2022 harvest under various storage conditions, from two regions in Azerbaijan. All hazelnut samples were contaminated both with aflatoxins (range = 1.1 to 7.2 µg/kg) and fumonisins (range = 0.12 to 0.30 mg/kg). Aspergillus section Flavi fungi were isolated and both aflatoxin producers and atoxigenic (incapable of producing aflatoxins) isolates were identified. Several members of vegetative compatibility group IT006, to which the Italian aflatoxin biocontrol isolate MUCL54911 belongs, were found to be native to Azerbaijan. In laboratory competition assays, MUCL54911 reduced aflatoxin produced by three types of Aspergillus fungi by 97.5 to 100%, which indicates that biocontrol could be an option to reduce aflatoxin in hazelnut. Future research efforts should be geared toward detecting and characterizing additional atoxigenic isolates, optimizing biocontrol application for hazelnut, and implementing agronomic and post-harvest practices to manage aflatoxin throughout the value chain. For effective implementation of integrated mycotoxin strategies, coalitions composed of farmers, research institutions, non-governmental organizations, private sector, and government agencies are needed.
FAO Azerbaijan, Baku, Azerbaijan.Azerbaijan State Agricultural University, Ganja, Azerbaijan; faqan.agayev@adau.edu.az.
IITA, Plant Pathology, Oyo Road, PMB 5320, Ibadan, Nigeria, 20001.IITA-Ibadan, , c/o Lambourn Ltd., Carolyn House, 26 Dingwall Road, Croydon, United Kingdom of Great Britain and Northern Ireland, CR9 3EE; r.bandyopadhyay@cgiar.org.
Universita Cattolica del Sacro Cuore - Campus di Piacenza, Sustainable Crop Production, Via Emilia Parmense 84, Piacenza, Italy, 29100; paola.battilani@unicatt.it.
International Institute of Tropical Agriculture, PMB 5320 Oyo Road, Ibadan, Ibadan, [Select a State/Province], Nigeria, 200001; A.Beltran@cgiar.org.
Mycotoxin contamination of hazelnut grown in Azerbaijan and Aspergillus communities associated with the crop.
Combustible cigarette (CC) smokers often use heated tobacco products (HTPs) to quit CC smoking; however, the role of HTPs in quitting CC smoking is uncertain. We evaluated the link between HTP use and quitting CC smoking considering the intensity of HTP use among a large nationally representative sample of Korean adults.We performed a cross-sectional study using data from the 2019 Community Health Survey in Korea. A total of 46,781 adult participants (current CC smokers and former CC smokers' < 5 years) were included and Poisson regression analysis was performed to evaluate the association between HTP use and quitting CC smoking among ever CC smokers.In ever CC smokers, compared with never HTP use, current daily HTP use was positively associated with quitting CC smoking (< 1-year; prevalence ratio (PR) = 1.63, 95% confidence interval (CI) = 1.36-1.96, 1-5 years; PR = 1.47, 95% CI = 1.36-1.60), whereas current non-daily HTP use showed an inverse association with quitting CC smoking (< 1-year; PR = 0.18, 95% CI = 0.12-0.29, 1-5 years; PR = 0.23, 95% CI = 0.17-0.31). Former HTP use was positively associated with short-term quitting CC smoking (PR = 1.38, 95% CI = 1.18-1.63), but negatively related to quit CC smoking after 1 year (PR = 0.81, 95% CI = 0.74-0.88).Daily use of HTPs appeared to be related to the increase in quitting CC smoking, but discontinuation of HTP use was significantly associated with the recurrence of CC smoking among former HTP users of 1-5 years.Among ever CC smokers, daily use of HTPs was positively associated with quitting CC smoking, but non-daily use of HTPs was inversely associated with quitting CC smoking. Former HTP use was linked to an increased likelihood of short-term quitting CC smoking but was significantly associated with CC smoking relapse after 1 year.
© The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Department of Family Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Republic of Korea.
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Association between heated tobacco product use and quitting combustible cigarette smoking among Korean adults.
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
© American Society of Health-System Pharmacists 2025. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
University of North Carolina Medical Center, XXX, NC, USA.
University of Kansas Cancer Center, XXX, KS, USA.
University of Texas MD Anderson Cancer Center, XXX, TX, USA.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Stay, stay, stay (our version): The value of staying power in navigating the challenges and changes of a career in clinical pharmacy.
To survive the harsh conditions of winter, woody perennial species such as grapevine have adapted to use environmental cues to trigger physiological changes to induce dormancy, acquire cold hardiness, and measure the length of winter to properly time spring budbreak. Human induced climate change disrupts these cues by prolonging warm temperatures in fall, reducing the depth and consistency of midwinter, and triggering early budbreak through false spring events. We evaluated variation in dormant bud cold hardiness and chilling hour requirements of 31 different grapevine varieties over 3 years. Differential thermal analysis was used to track changes in cold hardiness and deacclimation resistance was assessed throughout the season to track dormancy progression. Results demonstrate wide variation in maximum deacclimation rate (1.03 - 2.87 °C/day) among varieties under forcing conditions. Significant correlations were noted between wild species distributions or cultivar provenance with cold hardiness and deacclimation rates, demonstrating the likely climate-adaptive nature of these traits. When integrated with variation in cold hardiness, these rates revealed a relationship between winter cold hardiness, changes in deacclimation rate and budbreak phenology. Standardizing rates among varieties as deacclimation potential demonstrated a conserved response to chilling exposure among varieties that alters our interpretation of the concept of high and low chill varieties and chilling requirement in grapevine.
© The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
School of Integrative Plant Science, Horticulture Section, Cornell University, Geneva, NY, USA.
Plant and Agroecosystem Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Integrating cold hardiness and deacclimation resistance demonstrates a conserved response to chilling accumulation in grapevines.
This study explored working elements (E) and mechanisms (M) in interventions within different contexts (C), contributing to the outcome (O) of reducing (problematic) alcohol use among older adults. Guided by a realist evaluation approach, interviews with older adults participating in interventions (N = 20) were conducted. In different contexts, several working elements were identified: (1) receiving information about alcohol and health (risks); (2) paying attention to abstinence; (3) being in contact with and receiving support from peers and relatives; (4) maintaining contact with a practitioner or peer/buddy who is always or flexibly available for communication; and (5) learning to manage drinking behavior, and one important mechanism was identified: motivation. From the older adults' perspectives, there was a need to focus on social contact and support from peers and relatives, tracking and reflection, and motivation to reduce problematic alcohol use.
Tranzo Scientific Center for Care and Wellbeing, School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.
Tranzo Scientific Center for Care and Wellbeing, School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.Positive Lifestyle Foundation, Tilburg, The Netherlands.
Department of Health Promotion, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Journal of applied gerontology : the official journal of the Southern Gerontological Society
Working Elements in Interventions to Reduce Problematic Alcohol Use According to Older Adults: A Realist Evaluation.
Comorbidity amplifies mortality risk by approximately sixfold in cancer patients and affects about 26% of cervical cancer (CC) patients in Nigeria. However, its impact on CC outcomes has yet to be fully explored.We analysed data from the Lagos University Teaching Hospital and the NSIA-LUTH Cancer Center in Lagos, Nigeria, between January 2015 and December 2021. Based on the hypertension-augmented Charlson comorbidity index (hCCI), the hazard ratios (HRs) associated with CC mortality were estimated using Cox proportional hazards model.Our results showed a mortality rate of 30.1/100 women-years with a mean age at death of 59.8 years. Women with hCCI 2-6 had a significant increase in mortality risk in unadjusted (HR 1.68 [95% confidence interval {CI} 1.10 to 2.57]) and age-adjusted models (adjusted HR 1.57 [95% CI 1.02 to 2.42]) compared with those with hCCI 0. When CC stage was considered, the mortality risk gradient by hCCI was pronounced for late-metastatic CC with hCCI 2-6 (HR 2.32 [95% CI 1.23 to 4.39], increasing to 4.15 (95% CI 1.69 to 10.18) in the adjusted model compared with hCCI 0.Cervical cancer mortality risk increases with an increasing comorbidity score. Routine incorporation of comorbidity scoring in the clinical assessment of CC patients as well as the use of multidisciplinary cancer care teams may positively impact their clinical and psychosocial management.
© The Author(s) 2025. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.
Department of Clinical and Community Service, Blue-Pink Center for Women's Health, Lagos 100361, Nigeria.
Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos 100254, Nigeria.Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos 100254, Nigeria.
Department of Radiotherapy, College of Medicine, University of Lagos, Lagos 100254, Nigeria.Department of Radiotherapy, Lagos University Teaching Hospital, Lagos 100254, Nigeria.Lead Oncologist, NSIA-LUTH Cancer Centre, Lagos 100254, Nigeria.
Mortality risk stratification based on comorbidity status among cervical cancer patients in Lagos, Nigeria.
In 2005, the Centers for Medicare and Medicaid Services introduced the Coverage with Evidence Development program for items and services with limited evidence of benefit and harm for Medicare beneficiaries, aiming to generate evidence to determine whether they meet the statutory reasonable and necessary criteria for coverage. Coverage with Evidence Development requires participation in clinical studies approved by the Centers for Medicare and Medicaid Services (i.e. Coverage with Evidence Development-approved studies) as a condition of coverage. We examined the quality of evidence generated by Coverage with Evidence Development-approved studies compared with those that informed Centers for Medicare and Medicaid Services' initial Coverage with Evidence Development decisions (i.e. National Coverage Determination studies).Using Centers for Medicare and Medicaid Services' webpage, we identified all items and services covered under Coverage with Evidence Development and their Coverage with Evidence Development-approved studies. Through searching PubMed and Google Scholar, we identified original research articles that reported results for primary endpoints of Coverage with Evidence Development-approved studies. We then reviewed the initial Coverage with Evidence Development decision memos and identified National Coverage Determination studies that were original research.We characterized and compared Coverage with Evidence Development-approved studies and National Coverage Determination studies.From 2005 to 2023, 26 items and services were covered under the Coverage with Evidence Development program, associated with 196 National Coverage Determination studies (170 (86.7%) clinical trials and 26 (13.3%) registries) and 116 unique Coverage with Evidence Development-approved studies (86 (74.1%) clinical trials, 23 (19.8%) registries, 4 (3.4%) claims-based studies, and 3 (2.6%) expanded access studies). Among clinical trial studies, National Coverage Determination studies and Coverage with Evidence Development-approved studies did not differ with respect to multi-arm design (59.4% vs 68.6%; p = 0.15). However, among multi-arm clinical trial studies, National Coverage Determination studies were less likely than Coverage with Evidence Development-approved studies to be randomized (52.5% vs 93.2%; p < 0.001). Overall, National Coverage Determination studies less frequently had ≥ 1 primary endpoint focused on a clinical outcome measure (65.8% vs 87.9%; p = 0.006) and less frequently exclusively enrolled Medicare beneficiaries (3.1% vs 25.9%; p < 0.001). In addition, National Coverage Determination studies had smaller population sizes than Coverage with Evidence Development-approved studies (median 100 (interquartile range, 45-414) vs 302 (interquartile range, 93-1000) patients; p = 0.002). Among Coverage with Evidence Development-approved studies, 59 (50.9%) had not yet publicly reported results for the primary endpoint.Studies required under Medicare's Coverage with Evidence Development program more often used randomized study designs, had larger patient populations, enrolled US patients, and focused on clinical outcomes as primary endpoints than studies used to inform initial National Coverage Determinations. However, not all Coverage with Evidence Development-approved studies have thus far reported results, which could create uncertainty for patients, physicians, and payers regarding the clinical benefits of covered items and services.The Centers for Medicare and Medicaid Services' Coverage with Evidence Development program has successfully prompted generation of more robustly designed clinical studies to better inform clinical, regulatory, and coverage decisions compared to studies informing initial coverage decisions. Yet, opportunities exist to further strengthen the design and dissemination of studies required under this program.
Department of Internal Medicine, Yale New Haven Hospital, New Haven, CT, USA.Yale Collaboration for Regulatory Rigor, Integrity, and Transparency (CRRIT), Yale School of Medicine, Yale University, New Haven, CT, USA.
Department of Medicine, Stanford Medicine, Stanford University, Stanford, CA, USA.
Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Internal Medicine, Yale New Haven Hospital, New Haven, CT, USA.Yale Collaboration for Regulatory Rigor, Integrity, and Transparency (CRRIT), Yale School of Medicine, Yale University, New Haven, CT, USA.Department of Health Policy and Management, Yale School of Public Health, New Haven, CT, USA.Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.
Section of Cardiology, Department of Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
Characterization of studies considered and required under Medicare's coverage with evidence development program.
Platform trials typically feature a shared control arm and multiple experimental treatment arms. Staggered entry and exit of arms splits the control group into two cohorts: those randomized during the same period in which the experimental arm was open (concurrent controls) and those randomized outside that period (nonconcurrent controls). Combining these control groups may offer increased statistical power but can lead to bias if analyses do not account for time trends in the response variable. Proposed methods of adjustment for time may increase type I error rates when time trends impact arms unequally or when large, sudden changes to the response rate occur. However, there has been limited exploration of the degree of type I error inflation one can plausibly expect in real-world scenarios.We use data from the Adaptive COVID-19 Treatment Trial (ACTT) to mimic a realistic platform trial with a remdesivir control arm. We compare four strategies for estimating the effect of interferon beta-1a (the ACTT-3 experimental arm) relative to remdesivir (data from ACTT-1, ACTT-2, and ACTT-3) on recovery and death by day 29: utilizing concurrent controls only (the prespecified analysis), pooling all remdesivir arm data without adjustment (the unadjusted-pooled analysis), adjusting for time as a categorical variable, and a Bayesian hierarchical model implementation which adjusts for time trends using smoothing techniques (the Bayesian time machine ). We compare type I error rates and relative efficiency of each method in simulation settings based on observed ACTT remdesivir arm data.The unadjusted-pooled approach provided substantially different estimates of the effect of interferon beta-1a relative to remdesivir compared with the concurrent-only and model-based approaches, indicating that changes in recovery and death rates over time were not ignorable across different stages of ACTT. The model-based approaches rely on an assumption of constant treatment effects for each arm in the platform relative to control; error rates more than doubled in settings where this was not satisfied. Relative efficiency of the model-based approaches compared with the concurrent-only analysis was moderate.In simulation settings where key model assumptions were not met, potential efficiency gains from incorporation of nonconcurrent controls were outweighed by the risk of substantial type I error rate inflation. This leads us to advise against these strategies for primary analyses in confirmatory clinical trials, aligning with current FDA guidance advising against comparisons to nonconcurrent controls in COVID-19 settings. The model-based adjustment methods may be useful in other settings, but we recommend performing the concurrent-only analysis as a reference for assessing the degree to which nonconcurrent controls drive results.
Clinical Monitoring Research Program Directorate (CMRPD), Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Office of Biostatistics Research, Division of Clinical Research, NIAID, Bethesda, MD, USA.
Examining the bias-efficiency tradeoff from incorporation of nonconcurrent controls in platform trials: A simulation study example from the adaptive COVID-19 treatment trial.
D. Thuringer, G. Jego, G. Wettstein, O. Terrier, L. Cronier, N. Yousfi, S. Hébrard, A. Bouchot, A. Hazoumé, A.-L. Joly, M. Gleave, M. Rosa-Calatrava, E. Solary, and C. Garrido, Extracellular HSP27 Mediates Angiogenesis Through Toll-Like Receptor 3, The FASEB Journal 27, no. 10 (2013): 4169-4183, https://doi.org/10.1096/fj.12-226977. The above article, published online on 26 June 2013 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Loren E. Wold; the Federation of American Societies for Experimental Biology; and Wiley Periodicals LLC. The retraction has been agreed upon following an investigation into concerns raised by a third party which revealed inappropriate image panel duplications between this (Figure 3A) and another article published previously in a different scientific context. The investigation also revealed that the western blot panels of Figure 4E were later reused in a publication of the same author group, depicting different experimental conditions. Due to the number and the level of errors identified in the published figures, the authors and the editors have lost confidence in the presented data and consider the conclusions substantially compromised.
© 2025 Federation of American Societies for Experimental Biology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
RETRACTION: Extracellular HSP27 Mediates Angiogenesis Through Toll-Like Receptor 3.
Background: There is a growing body of evidence to support that utilizing fixed dose vs weight-based dosing of Four-Factor prothrombin complex concentrate (4F-PCC) for Factor Xa inhibitor (FXaI) reversal is safe and efficacious. Objectives: The primary objective of this study was the rate of hemostatic efficacy of weight-based (50 units/kg) vs fixed dose (2000 units) 4F-PCC for FXaI reversal in patients presenting with a non-neurologic hemorrhage. Methods: This was a multi-center, retrospective chart review from January 21, 2020, to January 21, 2022. Patients were included if they were greater than or equal to 18 years of age and received one dose of 4F-PCC for FXaI reversal for a non-neurologic bleed. Hemostatic efficacy for this study was defined as the absence of hemorrhagic progression confirmed with imaging, >2 g/dl decrease in Hgb within 6 hours of 4F-PCC administration, reports of further significant bleeding in chart note documentation within 48 hours and a maintained or increased anti-factor Xa level from baseline. Results: Fifty-nine patients were included in this study (29 in the weight-based group and 30 in the fixed dose group). Rate of hemostatic efficacy was similar between fixed and weight-based dosing (93.3% vs 93.1% P = 1). Conclusions: This study adds to current evidence suggesting that a fixed dose 4F-PCC is both safe and efficacious for FXaI reversal in non-neurologic bleeds.
Department of Pharmacy, St. Luke's Health System, ID, USA.
Fixed vs Weight-Based Dosing of Four-Factor Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Patients With a Non-Neurologic Hemorrhage.
Obviousness-type double patenting is allowed only in the US, but only if a terminal disclaimer and the same ownership are made for the expiry of the patent. Historically, this provision has hampered the entry of generic and biosimilar drugs due to the legal complexity and cost burden of resolving patent thickets accumulated by the originator companies. The United States Patent and Trademark Office (USPTO) proposed a change in the ruling in March 2024 to avoid double patenting if the patent to which it is tied in terminal disclaimer has any claims that have been invalidated as anticipated or obvious. This rule change aimed to promote innovation and competition by deterring strategies that leverage multiple patents for obvious variants to obstruct competitors. However, after receiving 349 comments on the proposed rule change, the USPTO withdrew its plan in December 2024 despite most comments favoring it. In a contrary move, the USPTO secured a court ruling that the terminal disclaimers do not apply to extended patent expiry due to the failure of the USPTO to prosecute a patent on a timely basis. The double patenting must end to enable more affordable generic and biosimilar drugs.
College of Pharmacy, University of Illinois, Chicago, IL, USA.
Contradicting rulings of the US patent office on double patenting jeopardize the generic and biosimilar drugs.
Sense of community (SoC) and social participation are considered resources for active aging but there is sparse empirical knowledge on the topic. We investigated these associations among senior housing residents. Data were derived from the cross-sectional BoAktiv senior housing survey (N = 278). Active aging was measured with the (blinded) Active Aging scale including subscales of will, ability, and possibility to act, and the frequency of activity. SoC was assessed with the revised Sense of Community Index and social participation was self-reported. Data were analyzed with linear regression and stratified by sex. We found that in both men and women, SoC and social participation were associated with the will to act and frequency of activity subscores. Additionally, SoC was associated with the active aging total score. The associations were slightly stronger in men than in women. These findings suggest that strengthening social engagement supports senior housing residents' active aging.
Folkhälsan Research Center, Helsinki, Finland.University of Jyväskylä, Gerontology Research Center and Faculty of Sport and Health Sciences, Finland.
University of Jyväskylä, Gerontology Research Center and Faculty of Sport and Health Sciences, Finland.Wellbeing Services County of Central Finland, Jyväskylä, Finland.
Sense of Community and Social Participation Underlying Active Aging Among Senior Housing Residents.
Department of Dermatology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan.National Defense Medical Center, School of Medicine, Taipei City, Taiwan.
Department of Dermatology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan.National Defense Medical Center, School of Medicine, Taipei City, Taiwan.Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
QJM : monthly journal of the Association of Physicians
Cutaneous larva migrans with eccrine involvement.
To investigate the recovery trajectories of physical function, activity performance, cognitive and psychological functions, and health related quality of life, as well as potential interaction effects, in individuals with COVID-19 treated in an intensive care unit (ICU).This prospective cohort study included patients with confirmed COVID-19 infection, treated in an ICU. Clinical assessments and self-ratings of functioning, disability and health were performed > 1 month and > 12 months after discharge from hospital.Among the 65 included individuals (mean age 56.6, SD 11) significant improvements in physical and psychological function were observed over time, although not reaching population norms. Cognition remained unchanged (MoCA median 27, IQR 4). At the 12-month follow-up, physical limitations in activity (RAND-36) were found to be associated with dyspnea (mMRC-Dyspnea), mental and physical fatigue (MFI-20), and walking endurance (6-minute walk test) (r2 0.509 p < 0.001). Role limitations due to physical health (RAND-36) was found to be associated with physical and mental fatigue (MFI-20) and pain (r2 0.530 p < 0.001).Despite improvements in functioning and health in this group of predominantly younger age recovery did not reach population norms. These results highlight persistent impairments and activity limitations that may necessitate long-term healthcare interventions.
Department of Clinical Sciences, Danderyd Hospital Division of Rehabilitation Medicine, Karolinska Institutet, Stockholm, Sweden.Department of Rehabilitation Medicine, Danderyd University Hospital, Stockholm, Sweden.
Persisting impairments after ICU-treated COVID-19 occurred in multiple areas including pain, endurance, dyspnea, mental and physical fatigue.Associated with these impairments were limitations related to physical functioning, including activity and role limitations.Co-ordinated assessment and interdisciplinary rehabilitation interventions are likely needed to target these impairments.
Examining recovery trajectories of physical function, activity performance, cognitive and psychological functions, and health related quality of life in COVID-19 patients treated in ICU: a Swedish prospective cohort study.
Université Paris-Cité, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France.French Alliance for Cardiovascular Trials (FACT), Paris.Institut national de la santé et de la recherche médicale INSERM_U1148/LVTS, Paris, France.
European journal of preventive cardiology
Navigating PCI Risks in Cancer Patients.
Grupo CENIEC, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador.
Instituto de Investigaciones Masira, Facultad de Ciencias de la Salud, Universidad de Santander (UDES), Bucaramanga, Colombia.
The positive impact of the Life's Essential 8 in the prevention of incident Heart Failure.
Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain.Cardiology Department, Quironsalud University Hospital, Madrid, Spain.
IRCCS Ospedale Policlinico San Martino, Genova, Italy.Department of Internal Medicine, University of Genova, Genova, Italy.
GLP1 agonists in cardio-oncology: is it time for a specific focus?
The necessity of prophylactic lateral neck dissection for cN0 papillary thyroid carcinoma (PTC) remains debated. This study aimed to compare traditional nomograms with machine learning (ML) models for predicting ipsilateral lateral and level II, III, and IV lymph node metastasis (LNM).Data from 1616 PTC patients diagnosed via fine needle aspiration biopsy from Hospital A were split into training and testing sets (7:3). 243 patients from Hospital B served as validation set. Four dependent variables-ipsilateral lateral, level II, III, and IV LNM-were analyzed. Eight ML models (Logistic Regression, Decision Tree, Random Forest-RF, Gradient Boosting, Support Vector Machine, K-Nearest Neighbor, Gaussian Naive Bayes, Neural Networks) were developed and validated using 10-fold cross-validation and grid search hyperparameter tuning. Models were assessed using 11 metrics including accuracy, area under the curve (AUC), specificity, and sensitivity. The best was compared with nomograms using the Probability-based Ranking Model Approach (PMRA).RF outperformed other approaches achieving accuracy, AUC, specificity, and sensitivity of 0.773/0.728, 0.858/0.799, 0.984/0.935, 0.757/0.807 in the testing/validation sets respectively for ipsilateral LLNM. A streamlined model based on the top ten contributing features that includes ipsilateral central lymph node metastasis rate, extrathyroidal extension, and ipsilateral central lymph node metastasis number retained strong performance and clearly surpassed a traditional nomogram approach based on multiple metrics and PMRA analysis. Similar results were obtained for the other dependent variables, with the RF models relying on distinct but overlapping sets of features. Clinical tool implementation is facilitated via a web-based calculator for each of the four dependent variables.ML, especially RF, reliably predicts lateral LNM in cN0 PTC patients, outperforming traditional nomograms.
© The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society.
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, 40016, China.Department of Breast and Thyroid, Women and Children's Hospital of Chongqing Medical University: Chongqing Health Center for Women and Children, 401120, China.
Department of Breast and Thyroid, Women and Children's Hospital of Chongqing Medical University: Chongqing Health Center for Women and Children, 401120, China.
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, 40016, China.
Intelligent Integrated Circuits and Systems Laboratory (SICS Lab), University of Electronic Science and Technology of China, 611730, China.
Department of Thyroid and Breast Surgery,Guangyuan Central Hospital, 628017, China.
The Journal of clinical endocrinology and metabolism
J Clin Endocrinol Metab. 2025-02-08;():.
Machine Learning: A Multicentre Study on Predicting Lateral Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma.
This study addressed associations of parents' socialization of children's positive and negative emotions with children's emotional skills and socio-emotional functioning in early childhood with families in Türkiye and the United States (U.S.). One hundred five parents (50 Turkish, 55 U.S.) and their 4- to 5-year-old children reminisced about family events. Videos were coded for parents' emotion coaching and dismissing. Parents self-reported expressiveness and reactions to children's emotions. Experimenters administered tasks assessing children's emotion masking and emotion understanding. Teachers reported children's social competence and behavior problems. Emotion socialization by Turkish and U.S. parents differed according to valence (positive, negative) and mode (expressiveness, reactions, discourse). For both Turkish and U.S. families, encouraging socialization of negative emotions related to children's better masking of negative emotions and poorer masking of positive emotions. For U.S. families, encouraging negative emotions related to children's poorer socio-emotional functioning. When parents encouraged positive emotions, Turkish children scored higher in masking negative emotions, whereas U.S. children scored higher in masking positive emotions and had better socio-emotional functioning. Results suggest that cultural values may influence emotion socialization and its relations to children's socio-emotional development. Particular attention should be paid to socialization modes and positive emotions.
Department of Early Childhood and Education, Aksaray University, Aksaray, Türkiye.
School of Management, Binghamton University, Binghamton, NY, USA.
Department of Psychological Science, University of California-Irvine, Irvine, CA, USA.
Department of Psychological, Health & Learning Sciences, College of Education, University of Houston, Houston, TX, USA.
Parental Emotion Socialization and Children's Emotional Skills and Socio-Emotional Functioning in Early Childhood in Türkiye and the United States.
Telerehabilitation has proven effective for stroke survivors, yet it is slowly implemented. We developed Initial Program Theories (IPTs) that focus on the telerehabilitation of stroke survivors in the United States to uncover the possible causal relationship between implementation strategies and outcomes.We created a conceptual framework to steer the development of IPTs. Then, we extracted concepts from theoretical frameworks reported in telemedicine implementation literature combined with feedback meetings with stakeholders with relevant experience.We developed a framework for implementing telerehabilitation that includes implementation levels, contextual domains, telerehabilitation technology, implementation phases, actors, targets, mechanisms, and outcomes. We created 27 IPTs that specify telerehabilitation interventions, implementation strategies, actors, targets, context, implementation mechanisms, and outcomes. The IPTs were refined and validated through feedback meetings.This study adds to the relatively scarce literature on IPT development. For each IPT, we elaborated on the implementation mechanism and how it could facilitate or hinder telerehabilitation implementation, an essential insight for researchers and professionals to plan successful implementation strategies. Understanding causal mechanisms helps identify implementation strategies that will work in the U.S. context and improve weak implementation strategies that are potentially significant or commonly used.
© 2025 The Author(s). PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation.
Quality, Outcome, Research and Analytics, American Heart Association, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.Department of Psychiatry & Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.Shirley Ryan AbilityLab, Chicago, Illinois, USA.
Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.Shirley Ryan AbilityLab, Chicago, Illinois, USA.
College of Liberal Arts and Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Department of Population Health Sciences, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, Utah, USA.
Department of Psychiatry & Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
PM & R : the journal of injury, function, and rehabilitation
Telerehabilitation of patients with stroke: Initial program theories for successful implementation.
Do narcissists enjoy better or worse wellbeing than others? Psychological theories disagree. In an attempt to reconcile them, we conducted a comprehensive cross-cultural meta-analysis testing the core hypotheses that grandiose narcissism would be associated with better wellbeing and vulnerable narcissism with worse wellbeing. We also hypothesized that these associations would be explained by self-esteem and would be stronger in countries higher on individualism. First, as hypothesized, grandiose narcissism was associated with better wellbeing and vulnerable narcissism with worse wellbeing. Second, as hypothesized, both associations became nonsignificant after controlling for self-esteem, suggesting that they are explained by self-esteem. Third, partly as hypothesized, the association between grandiose-but not vulnerable-narcissism and wellbeing was stronger in more individualistic countries. Results held across wellbeing forms (hedonic, eudaimonic) and methods (cross-sectional, longitudinal). Advancing psychological theory, we demonstrated that only grandiose narcissists enjoy better wellbeing, especially in individualistic countries, a phenomenon accounted for by their higher self-esteem.
University of Amsterdam, The Netherlands.
Personality & social psychology bulletin
Narcissism and Wellbeing: A Cross-Cultural Meta-Analysis.
This study aimed to investigate the chain mediating roles of anxiety and inhibitory control in the relationship between bullying victimization and internet addiction among Chinese adolescents, as well as the moderating effect of physical activity. A cross-sectional design was employed, sampling 1,585 adolescents from 5 provinces in China during February-March 2024. Data on bullying victimization, internet addiction, anxiety, inhibitory control, and physical activity were collected and analyzed using a moderated chain mediation model. The data suggest that bullying victimization is associated with internet addiction, and this association is also mediated by anxiety and inhibitory control. Furthermore, physical activity was found to significantly moderate the relationship between anxiety and inhibitory control. This study contributes to the understanding of how bullying victimization, anxiety, and inhibitory control are interrelated in the context of internet addiction development, with physical activity influencing this interplay. It highlights the potential of physical activity as a factor in mitigating the impact of bullying and its association with internet addiction.
School of Sports Science, Jishou University, Jishou, China.
Department of Basic Education, China Conservatory of Music, Beijing, China.
School of Sports Science, Jishou University, Jishou, China.Institute of Physical Education, Shanxi University of Finance and Economics, Taiyuan, China.
The Chain Mediating Effect of Anxiety and Inhibitory Control and the Moderating Effect of Physical Activity Between Bullying Victimization and Internet Addiction in Chinese Adolescents.
Effective healthcare practice requires interprofessional collaboration (IPC) between all members of the healthcare team. Preparing healthcare trainees for IPC has proven to be difficult. Research suggests that workplace learning has a vital role in acquiring IPC competencies. However, guidance is required for trainees to make optimal use of IPC workplace learning opportunities. This study asks (1) To what extent is guidance provided to medical trainees when learning to collaborate interprofessionally?; and (2) Who provides this guidance and how?We conducted a constructivist, qualitative study using iterative cycles of semi-structured interviews and reflexive thematic analysis. A purposive sample of medical trainees (N = 11), nurses (N = 9), advance practice clinicians (APCs)(N = 3) and attending physicians (N = 9) associated with a department of general internal medicine in a non-academic teaching hospital participated in this study. Data-analysis was informed by Billett's concept of guidance.Guidance on IPC was provided to medical trainees both intraprofessionally and interprofessionaly, be it limited, informal and implicit. Nurses and APCs provided more guidance on IPC than attending physicians. Guidance by attending physicians included implicit modelling and only became explicit in response to concerns raised about trainees' IPC by nurses. Nurses and APCs provided continuous guidance on various aspects of IPC but felt hampered by hierarchical issues to provide feedback. Trainees were more focused on feedback provided by attending physicians than they were aware of nurses' feedback.The potential of workplace learning to learn IPC competencies is currently hampered by a lack of explicit guidance. Optimizing the role of workplace learning in IPC competence development requires more explicit role modelling and collaborative intentionality by attending physicians, more critical reflection by trainees and a strengthening of the feedback role of nurses and APCs.
© 2025 The Author(s). Medical Education published by Association for the Study of Medical Education and John Wiley & Sons Ltd.
School of Health Professions Education, Department of Educational Development and Research, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
School of Health Professions Education, Department of Educational Development and Research, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.Catharina Hospital, Eindhoven, the Netherlands.
Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Guiding medical trainees' workplace learning for interprofessional collaboration-Looking to physicians or seeing nurses?
Two new compounds (1-2), together with six known ones (3-8), were isolated from the roots of Paeonia lactiflora Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds 1-8 were determined using LPS-induced RAW 264.7 cells. Compounds 2, 6, and 8 showed the most potent inhibitory activities on NO production with IC50 values of 17.34 ± 1.5, 27.22 ± 1.3, and 14.79 ± 1.7 μM, respectively. Compounds 4 and 7 showed moderate inhibitory activities. Compounds 3 and 5 showed relatively weak inhibitory activities.
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First-Class Construction Interdiscipline), Harbin, People's Republic of China.
College of Agriculture, Northeast Agricultural University, Harbin, People's Republic of China.
Two new compounds from the roots of Paeonia lactiflora Pall. and their anti-inflammatory effects.
The research examined the molecular interaction between nirmatrelvir (NIR), a drug used to treat COVID-19, and human serum albumin (HSA) using various techniques, viz., isothermal titration calorimetry (ITC), absorption, fluorescence, CD spectroscopy, and atomic force microscopy (AFM). ITC analysis showed that the NIR-HSA system possessed a moderate binding affinity, with a K a value of 6.53 ± 0.23 × 104 M-1 at a temperature of 300 K. The thermodynamic values demonstrated that the NIR-HSA complex was stabilized by hydrophobic contacts, hydrogen bonds, and van der Waals forces. The research also discovered modifications in the UV-Vis absorption spectrum of the protein as well as swelling of the HSA molecule when exposed to NIR, based on AFM results. The three-dimensional fluorescence spectral data indicated changes in the microenvironment around HSA's Trp and Tyr residues. Alterations in the protein structure (both secondary and tertiary structures) of HSA after NIR binding were verified using CD spectral studies in the far-UV and near-UV regions. The identification of the NIR binding site in subdomain IB (Site III) of HSA was predicted through competitive displacement experiments.
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.Department of Biological Sciences, Faculty of Natural and Applied Sciences, Sule Lamido University, Kafin Hausa, Nigeria.
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Oral and Craniofacial Sciences, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Faculty of Pharmaceutical Sciences, UCSI University, 56000 Kuala Lumpur, Malaysia.
Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
Assessing the molecular interaction between a COVID-19 drug, nirmatrelvir, and human serum albumin: calorimetric, spectroscopic, and microscopic investigations.
School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Ophthalmic Epidemiol. 2025-02-08;():1-5.
A Cross-Sectional Study of Demographic Representativeness of Glaucoma Patient Populations in Clinical Trials from 2006 to 2022.
The objective of the study was to perform the translation and adaptation of the Spanish version of the Spinal Cord Injury-Falls Concern Scale (SCI-FCS), and evaluate the psychometric properties.The original scale was translated from English to Spanish in accordance with international guidelines. Exploratory factor analysis was conducted to examine factor structure, while internal consistency was evaluated using Cronbach's alpha. The intraclass correlation coefficient (ICC) was calculated to examine test-retest reliability. Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC) were estimated. Criterion validity was assessed using the Spearman correlation coefficient.The Spanish SCI-FCS was administered to 81 manual wheelchair users with chronic SCI from a Spinal Cord Unit. Exploratory factor analysis revealed a two-factor structure. Internal consistency was high (α = 0.94) and test-retest reliability was excellent (ICC 2.1 = 0.99). SEM was 1.20 and MDC with 95% confidence interval was 3.31. The SCI-FCS score showed a positive correlation with fear of falling (r = 0.602, p < 0.001), Fatigue Severity Scale, r = 0.197 (p = 0.03), and the age of participants (r = 0.19, p = 0.04).The Spanish version of the SCI-FCS is a valid and reliable tool for assessing fall-related concerns in wheelchair users with chronic SCI.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.Centro Neuromédico, Granada, Spain.
Servicio de Medicina física y Rehabilitación, Complejo Asistencial Universitario de Salamanca.
UGC Medicina física y Rehabilitación, Hospital Universitario San Cecilio, Granada, Spain.
Departamento de Radiología y Medicina física, Universidad de Granada, Granada, Spain.
Departamento de Enfermeria, Facultad de Ciencias de La Salud, Universidad de Malaga, 29071 Andalucia TechMalaga, Spain. Grupo de Investigacion Clinimetria F14, Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA-Bionand)), IBIMA Plataforma-Bionand, Malaga, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.Departamento de Radiología y Medicina física, Universidad de Granada, Granada, Spain.UGC Medicina física y Rehabilitación, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.UGC Medicina física y Rehabilitación, Hospital Universitario Virgen de las Nieves, Granada, Spain.
The Spinal Cord Injury-Falls Concern Scale (SCI-FCS) is a self-report scale designed to evaluate the level of concern about falls during daily activities in individuals with spinal cord injuries who are dependent on manual wheelchairs.The SCI-FCS can help identify specific areas that require intervention, aiming to reduce concerns about falling among individuals with SCI in the Spanish-speaking population.The availability of a transculturally validated Spanish version of the SCI-FCS will enhance the accuracy and quality of assessments conducted by Spanish healthcare professionals and researchers, ultimately improving patient care and rehabilitation outcomes.
Cross-cultural adaptation and psychometric testing of the Spanish version of the Spinal Cord Injury Falls Concern Scale (SCI-FCS).
Green synthesized nanomaterials play a vital role in nanotechnology was due to its diverse applications. In the current study, flower shaped nanoclusters of zinc oxide nanoparticles (ZnONPs) was fabricated using the leaf extract of Centella asiatica (Linn.) by microwave-assisted method. The physico-chemical characterization of the green synthesized ZnONPs were further conducted by the UV-Vis spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and transmission electron microscopy analysis. The UV-Vis spectrum of the synthesized ZnONPs has showed characteristic absorption maximum at 363 nm. The XRD pattern of the same could confirm to have the crystalline nature of ZnONPs. Additionally, the FT-IR spectra have revealed the presence of characteristic stretching and bending vibrations of the Zn-O bond, along with those of phytochemicals that might have involved in ZnONPs stabilization. By the HR-TEM imaging, agglomeration of the nanoparticles and thereby the formation of flower-like clusters could be observed. Furthermore, the synthesized ZnONPs have remarkable antimicrobial activity against S. aureus and E. coli with inhibition zones of 15 ± 0.4 and 16.5 ± 1.0 mm respectively. The green synthesized ZnONPs showed no significant toxicity toward Artemia nauplii. Hence, the results of the study indicate the promising potential of the synthesized ZnO nanoclusters.
School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.
Preparative biochemistry & biotechnology
Prep Biochem Biotechnol. 2025-02-08;():1-14.
Facile microwave-assisted green synthesis and characterization of flower shaped zinc oxide nanoclusters using Centella asiatica (Linn.) leaf extract and evaluation of its antimicrobial activity and in vivo toxic effects on Artemia nauplii.
Increasing evidence has shown that low-dose nicotine could have preventive and therapeutic effects on ischemic stroke (IS). Nevertheless, direct evidence is still missing, especially key molecules and signal pathways.Mice were randomly assigned to one of three groups: the sham group, the control group, and the nicotine-treated group. In the control group, mice were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). In the nicotine-treated group, mice were exposed to 12 μg/ml nicotine in their drinking water for 1 month prior to undergoing surgery. For in vitro blood-brain barrier (BBB) model, hCMEC/D3 monolayers were prepared on Transwells and pre-treated with nicotine for 48 hours and then subjected to oxygen-glucose deprivation/reoxygenation (OGD/R). Moreover, RNA-seq was adopted to explore the potential targets and signaling pathways regarding the protective role of nicotine.MCAO/R resulted in significantly compromised BBB integrity and serious brain damage. Notably, pretreatment of mice with 12μg/ml nicotine for one month significantly reduced IS-induced BBB damage and its associated brain injury. In addition, the permeability of hCMEC/D3 monolayer endothelial cells was significantly reduced under OGD/R conditions, which could be ameliorated by nicotine pretreatment. The RNA-seq results showed that TGF-β and Wnt signaling pathways were associated with pathways associated with DEGs between OGD/R and OGD/R plus nicotine treatment. Finally, the activation of Wnt/β-catenin pathways could be antagonized by the α7 nicotine acetylcholine receptor (α7 nAChR) inhibitor α-BTX.These results demonstrate that nicotine treatment could alleviates the IS-compromised integrity of BBB by regulating the Wnt signal pathway through α7 nAChR.The study demonstrates that nicotine at low concentrations exerts neuro-protective effects by supporting the integrity of BBB and subsequent endothelial viability after ischemic stroke. This finding suggests that targeting the BBB, especially endothelial cells, with nicotine treatment is a promising therapeutic strategy for brain injury after ischemic stroke.
Research and Development Center, IMiracle (Shenzhen) Innovation Technology Co.,Ltd, Shenzhen, China.
Dongguan Hongfu Biological Technology Co., Ltd, Dongguan, China.
Laboratory Animal Center, Sun Yat-sen University, Guangzhou, China.
The protective effect of low-dose nicotine on ischemia stroke by maintaining the integrity of the blood-brain barrier.
The design of at-home stroke rehabilitation robots must be closely linked to the needs of users, especially stroke survivors and therapists, to ensure that such designs are effective in the home environment, which is less controlled than clinical environments. Translating user needs into the technical descriptors of a design is essential to this design process. This paper analyses user needs identified from interviews with stroke survivors and therapists in previous work.The relationship between user needs and the broad technical properties of rehabilitation robot design are related using the House of Quality, an approach from Quality Function Deployment. Technical benchmarks are identified from previous rehabilitation robot designs and technical priorities are determined from the House of Quality. An at-home upper limb stroke rehabilitation robot concept for supporting therapy activities in a vertical planar workspace is described and evaluated using the identified technical priorities.The proposed design, a constrained cable robot, is determined to be appropriate for the desired application based on the technical priorities from the House of Quality.
Department of Electrical and Computer Engineering, Queen's University, Kingston, Canada.
Department of Mechanical and Materials Engineering, Queen's University, Kingston, Canada.
School of Rehabilitation Therapy, Queen's University, Kingston, Canada.
Associates design features for rehabilitation robots with the needs of stroke survivors and rehabilitation therapists.Identifies priority design features based on their ability to address user needs.Demonstrates the process of applying the identified priorities to generate novel designs and proactively evaluate existing designs for their anticipated ability to meet user needs.
Disabil Rehabil Assist Technol. 2025-02-08;():1-9.
Design priorities for an at-home upper limb stroke rehabilitation robot.
The burden of ischemic heart disease (IHD) attributable to lead exposure in China remains poorly understood. Using data from the Global Burden of Disease 2019, we aim to explore the epidemiological trends and specific burdens, providing insights into environmental health. In 2019, the number of deaths and disability-adjusted life years of IHD attributable to lead exposure in China reached 105,857 and 1,899,139, respectively. The age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) were 6.46 and 101.29 per 100,000 population, respectively. The burden was higher in males than in females. The estimated ASMR is projected to decrease to 7.08 and 3.37 per 100,000 for males and females by 2030, while the ASDR is expected to decline to 100.57 and 45.30 per 100,000 for males and females. The burden of IHD attributable to lead exposure is substantial in China, highlighting the grave public health concern posed by lead pollution.
Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Department of Bioengineering, College of Life Sciences, Fujian Normal University, Fuzhou, China.
School of Mathematical Sciences, Harbin Normal University, Harbin, China.
Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
International journal of environmental health research
Int J Environ Health Res. 2025-02-08;():1-11.
Disease burden of ischemic heart disease attributable to lead exposure in China from 1990 to 2019, and projections until 2030.
This study investigated the relationship between air pollution and influenza incidence in Chongqing from 2013 to 2022 using a generalized additive model (GAM), analyzing 199,712 cases. Subgroup analyses were conducted to investigate the impact of age, gender, season, and the COVID-19. Influenza incidence was positively associated with PM2.5, PM10, SO2, NO2 and CO, but negatively with O3. SO2 had the most effect. In single-day lag models, the largest percentage changes in influenza incidence at lag0 for each pollutant were: 2.930% for SO2, 1.552% for CO, -0.637% for O3, 0.516% for PM2.5, and 0.405% for PM10. NO2 showed the largest change at lag11 (1.376%). In multi-day lag models, changes peaked at lag011-014. Stratified analyses revealed children aged 0-14 years as particularly vulnerable during the cold season and COVID-19 period. The study demonstrates that short-term lags and cumulative effects of air pollution exposure increase influenza incidence, significant for establishing influenza response strategies.
School of Public Health, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Research Center for Public Health Security, Chongqing Medical University, Chongqing, China.
Office of Health Emergency, Chongqing Municipal Health Commission, Chongqing, China.
Int J Environ Health Res. 2025-02-08;():1-14.
Short-term effects of ambient air pollution on influenza incidence in Chongqing, China: a time-series analysis.
Pelvic floor dysfunction (PFD) are common following stroke. Physiotherapy interventions such as pelvic floor muscle training (PFMT) seems to be effective in the general population with PFD, but its usefulness in stroke patients has rarely been addressed.We aimed to explore existing physiotherapy interventions and their influence in managing PFD in men and women stroke survivors.Eight major databases were searched from inception to date using appropriate keywords and search strings. We included experimental studies comparing physiotherapy to control interventions/alternate treatments. PFD were grouped under urinary incontinence (UI), bowel dysfunction (BD), and sexual dysfunctions (SD) based on the studies. Two reviewers independently screened the title and abstract, to determine the included studies and the third author resolved disputes.Fourteen studies were identified of which ten focused on the management of UI, one on BD, and three on the management of SD. PFMT was predominantly used to manage UI independently or combined with other forms of treatment such as timed voiding, intermittent catheterization, acupuncture, and drug therapy. BD was managed using anal sphincter strengthening exercises, PFMT, and bowel training. Management of SD for both men and women included comfortable and safe sexual position training, stretching, and PFMT. Studies found significant improvement in terms of symptoms of bladder and bowel incontinence, number of incontinence episodes and muscle strength on digital palpation of the pelvic floor muscles.Physiotherapy interventions including PFMT may help in managing the symptoms and improving the quality of life of stroke survivors with PFD.
Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.Centre for Comprehensive Stroke Rehabilitation and Research, Manipal Academy of Higher Education, Manipal, India.
Norwegian School of Sport Sciences, Department of Sports Medicine, Oslo, Norway.Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway.
Department of Neurology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Department of Community Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.
Department of Medicine, Dr. T.M.A. Pai Hospital, Udupi, MMMC, Manipal Academy of Higher Education, Manipal, India.
Physiotherapy interventions for pelvic floor dysfunctions in stroke survivors - a scoping review of literature.
Understanding spatial patterns of neutral and adaptive genetic variation and linking them to future climate change have become crucial in assessing the genetic vulnerability of species and developing conservation strategies. Using a combination of genomic approaches, this study aimed to explain the demographic history, predict the adaptive potential in Washingtonia palm populations on the Baja California Peninsula (BCP) and southern California and determine the geographic areas where climate change will have the most drastic effects.We used over 5000 SNPs from 155 individuals across 18 populations spanning the entire distribution range of Washingtonia palms on the BCP and southern California. We examined past and current genetic diversity distribution patterns and identified outliers using genetic differentiation and genotype-environment association methods. Genetic vulnerability was predicted, and species distribution modeling was done to the geographic regions that will be at risk under future climate scenarios.Demographic modeling supported a bottleneck related to the Wisconsin glaciation, which was stronger and longer in northern Washingtonia populations. Genomic diversity presented a strong relationship to geography and provided evidence for range expansions from several refugia. Gradient Forest Analysis revealed that the genetic variation was primarily shaped by variables related to latitude and temperature during the coldest quarter, indicating adaptation to local thermal environments. We found limited adaptive potential and high levels of genetic vulnerability in lowland southern and central populations. Accordingly, species distribution modeling found that the southern distribution range will be affected by climate change, particularly under the high-emission scenario.Our findings include a history of population bottleneck related to postglacial range expansion, population divergence with limited gene flow, and probable future changes in distribution under changing conditions. Under long-term climate change, Washingtonia's southern and central lowland populations will experience harsher climate conditions and strong genomic offset.
© The Author(s) 2025. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Centro de Investigaciones Biológicas Noroeste S.C., 23205 La Paz, BCS, México.
School of Integrative Plant Science, Section of Plant Biology and the L.H. Bailey Hortorium, Cornell University, Ithaca NY 14853 USA.
Everchanging range: How the changing environment has influenced the genetic diversity and differentiation of an iconic North American palm species.
Correction to: Enrichment of laccase production by Phoma herbarum isolate KU4 under solid-state fermentation by optimizing RSM coefficients using genetic algorithm.
Loneliness, as one of the most profound and universal emotional challenges faced by modern individuals, has become a focal point of scientific research. Particularly, negative body image and abnormal eating behaviors stand out as critical factors that contribute to loneliness. The complex and multidimensional effects of these factors on loneliness gain significance due to their impact on individuals' mental health and social connections. The purpose of this study is to examine the mediating and moderating roles of food addiction in the relationship between body image and loneliness. The sample of the study consisted of 345 individuals aged between 18 and 40, 229 of whom (66.4%) were female. Data were collected using the short -form UCLA Loneliness Scale, the Body Image Scale, and the Modified Yale Food Addiction Scale. Hayes' Model 4 was used to test the mediating role, while Hayes' Model 1 was used to examine the moderating role. The findings of the study indicate that positive body image negatively predicts both loneliness and food addiction. Moreover, after controlling for gender, age, and income level, food addiction was found to act as a mediator in the relationship between body image and loneliness. Additionally, food addiction demonstrated a moderating effect on this relationship. In other words, negative body image can increase food addiction, which, in turn, amplifies feelings of loneliness. Conversely, reducing food addiction may alleviate feelings of loneliness by improving negative body image. These results contribute to a better understanding of the psychological effects of food addiction and the dynamic relationship between body image and loneliness.
Institute of Educational Sciences, Van Yüzüncü Yıl University, Van, Turkey.
Van Education And Research Hospital, Van, Turkey.
The mediating and moderating effect of food addiction in the relationship between body image and loneliness.
This study aimed to investigate the association of the fibrinogen-to-albumin ratio (FAR) and all-cause mortality as well as cardiovascular mortality in patients on dialysis with acute coronary syndrome (ACS). Furthermore, we explored the incremental prognostic value of incorporating the FAR into the Global Registry of Acute Coronary Events (GRACE) score.We retrospectively enrolled 1035 patients on dialysis with ACS between January 2015 and June 2021. The primary outcome was all-cause mortality, and the secondary outcome was cardiovascular mortality. Multivariate Cox regression model, restricted cubic spline analysis, and C-statistic were performed to evaluate the prognostic value of FAR on outcomes.After a median follow-up of 21.8 months, 369 (35.7%) patients died, including 250 cardiovascular deaths. Patients with the highest FAR tertile had significantly increased risks of all-cause mortality (46.1% vs 27.8%; adjusted hazard ratio [HR], 1.790; 95% confidence interval [CI], 1.372-2.336) and cardiovascular mortality (33.0% vs 16.5%; adjusted HR, 2.086; 95% CI, 1.496-2.908) compared to those in the lowest tertile. Restricted cubic spline analysis revealed a J-shaped association between the FAR and all-cause mortality and cardiovascular mortality, with HRs increasing significantly when the FAR exceeded 94.15. Furthermore, integrating the FAR into the GRACE score significantly improved its predictive accuracy for all-cause mortality and cardiovascular mortality, as measured by C-statistic, continuous net reclassification index, and integrated discriminatory index.In patients on dialysis with ACS, the FAR was independently associated with increased risks of all-cause mortality and cardiovascular mortality. Incorporating the FAR might improve the predictive accuracy of the GRACE score in patients on dialysis with ACS.
© The Author(s) 2025. Published by Oxford University Press on behalf of Fellowship of Postgraduate Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing 100029, China.China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100005, China.
Department of Cardiology, Fuwai Central China Cardiovascular Hospital, No.1 Fuwai Avenue, Zhengdong New District, Zhengzhou 451460, China.
Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing 100029, China.Department of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, 2 Yinghua Dongjie, Beijing 100029, China.
Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing 100029, China.
Association of fibrinogen-to-albumin ratio with all-cause and cardiovascular mortality in patients on dialysis with acute coronary syndrome.
To compare the efficacy of two one-handed face mask ventilation techniques. Secondarily, we also assessed the effect of hand size on the performance of both these techniques.Eighty subjects were randomized into the EO group and the EC group. After receiving face mask ventilation training, they carried out one-handed mask ventilation on a simulation model according to the order of EO technique-EC technique or EC technique-EO technique, and they performed each face mask ventilation technique for five consecutive ventilations. The primary outcomes were the time of the first chest undulation and the total number of chest undulations in the five operations. A questionnaire evaluated the subjects' feelings of simplicity and comfort regarding the two techniques.Compared with the EC technique, the first success time was significantly shorter with the EO technique (17.69 ± 11.32 seconds vs 8.39 ± 8.08 seconds, P < 0.001), and the EO technique produced an improved successful ventilation rate (50.00% ± 33.89% vs 77.00% ± 28.84%, P < 0.001). For the EC technique, the first success time and successful ventilation rate of male subjects were better than those of female subjects (P < 0.05), whereas the first success time and successful ventilation rate in males and females did not significantly differ from each other for the EO technique (P > 0.5). Most subjects reported that the EO technique was simpler and more comfortable than the EC technique.On the simulation model, compared to the one-handed EC face mask ventilation technique, the EO technique is more conducive to the learning and mastery of novices and small-handed operators.
Comfort Oral Care Center, Hospital of Stomatology, Wuhan University, No. 9, Wudayuan Road, Donghu High and New Technical Development Zone, Wuhan, Hubei, 430079, China.
Emergency Center, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan, Hubei, 430071, China.
Department of Anesthesiology, The People's Hospital of Ying Shan, No. 166,West Riverside Road, Wenquan Town, Yingshan County, Huanggang, Hubei, 438700, China.
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan, Hubei, 430071, China.
Comparison of one-handed face mask ventilation techniques on the simulation model: EO technique and EC technique.
The palmar plate is a crucial structural part of hand, associated with metacarpophalangeal and interphalangeal joints. Pediatric disorders involving the palmar plate of thumb metacarpophalangeal joint include trigger thumb, hyperextension, instability, and dislocation. While anatomical differences exist between children and adults, detailed microstructure evaluations in infants remain unexplored. In this study, we provide a histological and structural assessment of the previously unresolved microstructure of the palmar plate in the thumb metacarpophalangeal joint of infant Japanese macaques (Cercopithecidae, Macaca fuscata), a relevant model for human development. Histological staining (light microscopy) and scanning electron microscopy were employed to visualize the three-dimensional microstructure. The palmar plate of the infant macaque was found to contain (1) elastic fibers, (2) hyaline cartilage composed of type II collagen, and (3) type I collagen fibers arranged in distinct patterns. The cartilaginous region exhibited a reticulate fiber arrangement on its periphery, while the membranous region displayed dense and complex fibers on the proximal phalanx side and parallel on the metacarpal side, respectively. This is the first comprehensive three-dimensional investigation of the infant's thumb's palmar microanatomy, providing a foundation for understanding its development and implications for pediatric disorders.
Department of Orthopedic Surgery, Faculty of Medicine, Oita University, 1-1 Idaigaoka Hazama-Machi, Yufu City, Oita, 879-5593, Japan. h-sato@ssu.ac.jp.
Department of Orthopedic Surgery, Faculty of Medicine, Oita University, 1-1 Idaigaoka Hazama-Machi, Yufu City, Oita, 879-5593, Japan.
Three-dimensional architecture of the palmar plate of the thumb metacarpophalangeal joint in infant macaque.
In this paper, electronic absorbance and fluorescence spectra of 4-Pentylphenyl 4-n-benzoate derivatives have been measured in 29 solvents, which are non-polar, polar protic and polar aprotic solvents, and electronic transitions that vary depending on the solvent are identified. As the solvent polarity increases, the forbidden energy difference between the frontier orbitals decreases. The statistical models in order to describe the solvent effect were derived using different solvent parameters. Quite complex and multiple absorbance transitions were observed in different solvent environments. Local fluorescence transition and intramolecular charge transfer occurred in the fluorescence spectra. Absorbance transitions are global transitions, and π*←π is the absorbance electronic transition. The frontier molecular orbitals and electrostatic potential surface were founded using quantum chemical calculations. Refractive indices were found with five different methods and forbidden energy gaps were found with the Tauc method. The forbidden energy ranges were found around 4.1 and 4.5, and the forbidden energy gap decreased as the alkyl chain became longer. All compounds can be defined as insulation materials according to the forbidden energy range. Refractive index values close to the E7 liquid crystal mixture used in liquid crystal display panels were found in the investigated liquid crystals.
Faculty of Sciences and Letters, Department of Physics, Bitlis Eren University, Bitlis, 13000, Türkiye. ygsidir@beu.edu.tr.
Faculty of Sciences and Letters, Department of Physics, Bitlis Eren University, Bitlis, 13000, Türkiye.
The Optical Properties, UV-Vis. Absorption and Fluorescence Spectra of 4-Pentylphenyl 4-n-benzoate Derivatives in Different Solvents.
A chemosensor (CNS) built on a naphthalene fluorophore was developed, featuring a disulfide-bridged dimer structure. The probe CNS was completely characterized by the usual spectral analysis methods like 1H NMR, 13C NMR, and HR-MS. The CNS probe selectively detects Cu2+ ions and subsequently recognizes the amino acid tryptophan in a semi-aqueous medium of DMF:H2O solution. The detection of Cu2+ ions occur via three distinct mechanisms: suppression of the photoinduced electron-transfer process (PET), arrested rotation of diuryl groups leading to conformational change, and a blue-shifted fluorescence enhancement through intramolecular charge-transfer (ICT). With a 1:1 complexation ratio and a detection limit of 2.14 x 10-4 M, the CNS probe has been successfully applied in various practical scenarios, including real water sample analysis, glyphosate detection, smartphone-based color detection, and Cu2+ ion testing using a cotton-swab method.
© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Fluorensic Materials Lab, Division of Physical Sciences, Karunya Institute of Technology and Sciences, Deemed-to-be University, Karunya Nagar, Coimbatore, 641114, India.
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Fluorensic Materials Lab, Division of Physical Sciences, Karunya Institute of Technology and Sciences, Deemed-to-be University, Karunya Nagar, Coimbatore, 641114, India. nandhakumar@karunya.edu.
A Dual-Functional Fluorescent Chemosensor Derived from Naphthalene Dithiouryl for Cu2+: Applications in Water Analysis, Logic Gates, Swab Tests, and Pesticide Monitoring.
To understand the lived experiences of Ethiopian women who self-identify as breast cancer survivors, particularly facilitators, and barriers to engaging with care in biomedical settings.Between November 2022 and January 2023, six focus group discussions were conducted in Amharic with 44 breast cancer patients and survivors in Adama, Ethiopia, stratified based on HIV status and participation in available peer support groups at their treatment hospital. Thematic analysis was conducted, with methodology reported in accordance with the Consolidated Criteria for Reporting Qualitative research checklist.Our analysis identified four key areas along the continuum of care: (1) recognition of BC-related symptoms, (2) seeking clinical care for BC symptoms, (3) adherence to BC treatment plans, and (4) coping strategies during ongoing care. Known facilitators for engagement in BC care included health education programming as well as emotional and financial support from loved ones and fellow survivors. However, participants described several barriers to clinical care such as the perception that BC is a death sentence, conflict between spiritual/traditional and clinical approaches to care, and fragmentation of care across multiple health facilities and providers.Based on some of the identified barriers to care, future efforts to enhance cancer care in Ethiopian settings should consider national awareness campaigns for BC to dispel local myths and misconception about BC, formal partnerships between faith-based community leaders and health care providers, and the use of family- and community-centered models of cancer care in biomedical settings.Recognition of psycho-oncological challenges to accessing clinical care for BC and providing opportunities for peer support and positive spirituality to navigate these challenges may improve patients' experiences in the Ethiopian biomedical system and reduce the potential negative experiences of future patients.
Adama Hospital Medical College, Adama, Ethiopia. biniyamtefera.md@gmail.com.
City University of New York Graduate School of Health and Health Policy, New York, NY, USA.
City University of New York Graduate School of Health and Health Policy, New York, NY, USA.Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Addis Ababa University, Addis Ababa, Ethiopia.
Adama Hospital Medical College, Adama, Ethiopia.
Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Albert Einstein College of Medicine, Bronx, NY, USA.
Journal of cancer survivorship : research and practice
A qualitative study on the psycho-oncological experiences of women navigating breast cancer diagnosis, treatment, and survivorship in Ethiopia.
Carbon dots (CDs) are extensively utilized in biomedicine, optical devices, and sensing due to their low toxicity, excellent optical properties, and ease of synthesis. Nonetheless, there is ongoing discussion over the comprehensive investigation of CDs photoluminescence (PL) process because of their intricate architectures and surface functions. Carbon dots (CDs) and CD/PVP composites were one step synthesized in a hydrothermal process using citric acid and NaOH as precursors. Due to surface defects of CDs after incorporating into Polyvinylpyrrolidone (PVP) both shift in color as well as change in emission is observed. It shows the enhancement of the luminescence property of CDs/PVP and the application of CD/PVP composite in the field of optical emission. Further for practical application, emission of white light emitting diodes (WLEDs) was demonstrated by coating a 370 nm UV-LED with CD/PVP composite. The WLED shows significant CRI, good S/P ratio, the color gamut score Rg and color fidelity score Rf which are essential features for a good light source. Our research offers a valuable reference for CD/PVP composites in a facile, low temperature and low-cost hydrothermal process and developing WLED with UV-LED and metal free phosphors.
Ramniranjan Jhunjhunwala College, Ghatkopar, Mumbai, 400086, India.
Ramniranjan Jhunjhunwala College, Ghatkopar, Mumbai, 400086, India. vaishaliraikwar@rjcollege.edu.in.
GN Khalsa College, Matunga, Mumbai, 400019, India.
Synthesis of Carbon Dots/PVP Composite for White Light Emitting Diode (WLED) Application.
Lurie Children's Hospital, Chicago, 225 E Chicago Ave, Box #21 (cardiology), IL, 60611, USA. nhusain@luriechildrens.org.
Texas Children's Hospital, Houston, USA.
Lurie Children's Hospital, Chicago, 225 E Chicago Ave, Box #21 (cardiology), IL, 60611, USA.Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
This study aimed to evaluate the clinical and radiological outcomes of two patient groups with congenital kyphosis and kyphoscoliosis who underwent posterior surgical correction using Schwab grade 3-4 and Schwab grade 5-6 osteotomies.A retrospective analysis was conducted on 58 patients (35 females and 23 males; mean age: 16.2 yr). Radiological evaluations included preoperative,postoperative,and last follow-up measurements of segmental kyphosis, scoliosis, lumbar lordosis(LL), C7-central sacral vertical line[C7-CSVL] and sagittal vertical axis [SVA], and pelvic parameters (pelvic incidence [PI],pelvic tilt [PT], sacral slope [SS].Clinical evaluations included Scoliosis Research Society-22r (SRS-22r) scores and Oswestry Disability Index (ODI) scores at preoperative and last follow-up time points.The mean deformity correction was 53.4%. Preoperative segmental kyphosis angles for Schwab grade 3-4 osteotomy (group 1) and Schwab grade 5-6 osteotomy (group 2) were 66.9° and 104.9°, respectively.The last follow-up angles were 33.1° and 48.2° (p < 0.001).No significant loss of correction was observed in either group (p > 0.05). SRS-22r scores improved significantly at the last follow-up (p < 0.001).Similarly, ODI scores improved significantly in both groups (p < 0.001).Neurological complications occurred in 14 (24.1%) patients,including dura injury, spinal nerve root injury, transient incomplete neurological deficits, and spinal cord compression.Mechanical complications were reported in 14 (24.1%) patients and included rod fractures, proximal junction kyphosis, pedicle screw malposition, and pedicle screw loosening.Posterior surgical correction using Schwab grade 3-4 and Schwab grade 5-6 osteotomies yields satisfactory radiological and clinical outcomes in patients with congenital kyphosis and kyphoscoliosis. However, higher osteotomy grades, necessitated by greater deformity severity, are associated with increased complication rates.
Tatvan Can Hospital, Bitlis, Turkey. md.hakanakgun@gmail.com.Baltalimanı Kemik Hastalıkları Hastanesi, Istanbul, Turkey. md.hakanakgun@gmail.com.
Baltalimanı Kemik Hastalıkları Hastanesi, Istanbul, Turkey.TC İstanbul Rumeli Üniversitesi, Istanbul, Turkey.
Baltalimanı Kemik Hastalıkları Hastanesi, Istanbul, Turkey.
Baltalimanı Kemik Hastalıkları Hastanesi, Istanbul, Turkey.Van Akdamar Hospital, Van, Turkey.
Baltalimanı Kemik Hastalıkları Hastanesi, Istanbul, Turkey.Düzce Akçakoca Hospital, Düzce, Turkey.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Comparison of clinical and radiological outcomes of SRS-Schwab grade 3-4 and SRS-Schwab 5-6 osteotomies in congenital kyphosis and kyphoscoliosis patients.
To investigate the feasibility of combined robotic rectal surgery and transanal total mesorectal excision (hybrid robotic surgery).Among 143 robotic rectal surgeries performed from 2017 to 2022, 85 were hybrid robotic surgeries and were analyzed in this study. The cohort comprised 59 males and 26 females with a mean age of 65.8 years old and a mean body mass index of 22.6 kg/m2. The cStage was I in 20 cases, II in 21, III in 36, IV in 4, and other in 4. The operation types were low anterior resection in 21 cases, intersphincteric resection in 27, abdominoperineal resection in 32, total pelvic exenteration in 2, and other in 3. Twelve patients (14.1%) received neoadjuvant chemotherapy or chemoradiotherapy, and 39 (45.9%) underwent lateral lymph node dissection.The mean operation time for total mesorectal excision was 302.7 min, and the median blood loss was 71.5 ml. No cases required conversion to laparotomy. The median length of postoperative hospital stay was 15.9 days. Complications of Clavien-Dindo grade ≥ 3 occurred in 3 cases (4.2%). Urinary dysfunction occurred in 6 cases (8.3%). Three (4.2%) patients were diagnosed with positive circumferential resection margins.Hybrid robotic surgery is safe and oncologically feasible.
© 2025. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.
Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan. kashihara.hideya@tokushima-u.ac.jp.
Department of Surgery, Institute of Health Biosciences, The University of Tokushima, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan.
Feasibility of hybrid robotic rectal surgery.
Despite its small size the cerebellum is an anatomically complex and functionally important part of the brain. Previous studies have demonstrated associations between characteristic features/anatomic anomalies of cerebellum and psychiatric disorders. However, the potential causal relationships are unknown. In this study, a bidirectional two-sample Mendelian randomization approach was employed to investigate single nucleotide polymorphism (SNP) heritability and genetic causal associations between 77 imaging derived phenotypes (IDPs) of the cerebellum and major psychiatric disorder, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia (SCZ) and attention deficit hyperactivity disorder (ADHD). We identified thirty IDPs for which there was evidence of a causal effect on risk of MDD, BD, SCZ and ADHD. For example, 1 s.d. increase in the mean diffusivity (MD) of the left superior cerebellar peduncle was associated with 32% lower odds of BD risk. Reverse MR indicated that psychiatric disorders was associated with fourteen IDPs. For example, MDD were causally associated with three IDPs of gray matter volume (GMV) of right and left X cerebellum, and vermis crus II cerebellum. These results suggested that there were genetic causal associations between psychiatric disorders and certain cerebellum regions, such as the cognitive function of posterior cerebellar lobes and the connection of cerebellar to cerebrum. Further investigations need to enhance prediction and intervention strategies for potential psychiatric disorder risks.
© 2025. Springer-Verlag GmbH Germany, part of Springer Nature.
Medical Psychological Center, The Second Xiangya Hospital, Central South University, 139 Renmin Rd, Changsha, Hunan, 410011, China.
Medical Psychological Center, The Second Xiangya Hospital, Central South University, 139 Renmin Rd, Changsha, Hunan, 410011, China. zhangyipsy@csu.edu.cn.Medical Psychological Institute of Central South University, Central South University, Changsha, China. zhangyipsy@csu.edu.cn.National Clinical Research Center on Mental Disorders (Xiangya) and National Center for Mental Disorder, Changsha, China. zhangyipsy@csu.edu.cn.
European archives of psychiatry and clinical neuroscience
Eur Arch Psychiatry Clin Neurosci. 2025-02-08;():.
Associations between cerebellum and major psychiatric disorders: a bidirectional Mendelian randomization study.
University of Texas Medical Branch, John Sealy School of Medicine, Galveston, TX, USA.
Brigham and Women's Hospital, Department of Dermatology, Boston, MA, USA.Harvard Medical School, Boston, MA, USA.
University of Texas Medical Branch, John Sealy School of Medicine, Galveston, TX, USA.Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
Department of Dermatology, University of Texas Medical Branch, Galveston, TX, USA.
Department of Dermatology, University of Texas Medical Branch, Galveston, TX, USA. ammunozg@utmb.edu., 1005 Harborside Dr, Galveston, TX, 77555, USA. ammunozg@utmb.edu.
Vitiligo and alopecia areata are not associated with an increased risk of venous thromboembolism: a large population-based cohort study.
Hypercholesterolemia is a major risk factor in the development of cardiovascular diseases. Statins have been the primary treatment for reducing LDL cholesterol for years; however, adverse events related to their use have led to the development of alternative therapies, such as ezetimibe, bempedoic acid, and PCSK9 inhibitors, including alirocumab, evolocumab, and inclisiran. The study is aimed at comparing the consumption and costs of lipid-lowering drugs in the first half of 2023 (21,446,011.54 DDD and 10,974,495.47 €) and 2024 (19,493,540.71 DDD and 12,260,634.95 €) to assess the economic impact of new therapies in the management of dyslipidemia and adherence to guidelines. Dispensing data, without access to patient data, were collected from private community pharmacies and hospital and district pharmacies. Drug consumption was measured using the ATC classification system and the defined daily dose (DDD). The study revealed a trend toward a reduction in the use of traditional statin monotherapy and an increase in more recent and combined therapies. Statins showed a significant reduction from 42% in the first half of 2023 to 30% in the first half of 2024. Combined therapies, such as statins with ezetimibe, showed no change in trend, maintaining a 17% share in both periods. New therapies, such as PCSK9 inhibitors, demonstrated an increase from 33% in the first half of 2023 to 40% in the first half of 2024, while bempedoic acid, either as monotherapy or in combination with ezetimibe, remained below 2%. In recent years, the treatment of dyslipidemia has seen the introduction of many therapeutic alternatives. Bempedoic acid, recently introduced and less expensive, when used as an adjunct therapy with statins and ezetimibe, could reduce side effects and improve therapeutic efficacy without immediately resorting to higher-cost injectable drugs such as evolocumab, alirocumab, and inclisiran. Monitoring prescription trends and costs is essential to maintain the sustainability of the healthcare system, enabling investments in innovation and effective therapies without waste.
Pharmacy Department, Asl Napoli 3 Sud, Dell'amicizia Street 22, 80035, Nola, Naples, Italy. f.ferrara@aslnapoli3sud.it.
Ministry of Health, Viale Giorgio Ribotta 5, 00144, Rome, Italy.
Italian Society of Hospital Pharmacy (SIFO), SIFO Secretariat of the Lombardy Region, Via Carlo Farini, 81, 20159, Milan, Italy.
University of Naples Federico II, Domenico Montesano Street, 49, 80131, Naples, Italy.
Pharmaceutical Department, Asl Salerno, Salvatore Giordano Street 7, 84014, Nocera Inferiore, Salerno, Italy.
General Direction for Health Protection and Coordination of the Campania Regional Health System, Naples, Italy.
Director Pharmacy Department, Asl Napoli 3 Sud, Dell'amicizia Street 22, 80035, Nola, Naples, Italy.
Pharmaceutical Department, Asl Napoli 3 Sud, Marittima Street 3, 80056, Ercolano, Naples, Italy.
Healthcare Director Asl Napoli 3 Sud, Marconi Street 66, 80059, Torre del Greco, Naples, Italy.
General Director Asl Napoli 3 Sud, Marconi Street 66, 80059, Torre del Greco, Naples, Italy.
Naunyn-Schmiedeberg's archives of pharmacology
Naunyn Schmiedebergs Arch Pharmacol. 2025-02-08;():.
Considerations on the sustainability of hypercholesterolemia treatment in the context of new drugs on the market: data from Campania, Italy.
Protodioscin (PRO) is a furostanol saponin with antioxidant and anti-inflammatory properties. However, there is no proof against nociception and diarrhea. The study aims to investigate the antinociceptive and antidiarrheal effects of PRO, comparing its efficacy with diclofenac sodium (DFS) and loperamide (LOP) using in vivo and in silico methods. Antinociceptive activity was evaluated using the acetic acid-induced writhing and formalin-induced paw licking tests, and antidiarrheal effects were assessed via castor oil-induced diarrhea in mice. Mice were divided into groups receiving PRO (2.5 and 10 mg/kg, p.o.), DFS (25 mg/kg, p.o.), LOP (3 mg/kg, p.o.), or combinations. Molecular docking studies were conducted on COX-1, COX-2 enzymes, and the Mu-opioid receptor (MOR), with toxicity predictions performed for safety profiling. In vivo results demonstrated that PRO significantly (p < 0.05) reduced pain and diarrhea in animals. PRO at 10 mg/kg, showed comparable efficacy to DFS and LOP (25 and 3 mg/kg) in both models. Molecular docking revealed that PRO had stronger binding affinities with COX-1 (‒10.0 kcal/mol), COX-2 (‒9.6 kcal/mol) enzymes, and MOR (‒7.7 kcal/mol) compared to standard drugs. Toxicity predictions indicate PRO is relatively safe in some toxicity parameters. PRO exhibits significant antinociceptive and antidiarrheal activities comparable to DFS and LOP, making it a promising natural alternative for managing pain and diarrhea. Additional clinical trials and pharmacokinetic assessments are required to evaluate its long-term safety for use.
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh.
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh. razinaown@yahoo.com.
Department of Chemistry, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Department of Drug Science and Technology, University of Turin, 10124, Turin, Italy.
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh. dmt.islam@bsmrstu.edu.bd.Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj, 8100, Bangladesh. dmt.islam@bsmrstu.edu.bd.Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. dmt.islam@bsmrstu.edu.bd.
Assessments of protodioscin's antinociceptive and antidiarrheal properties: in vivo and in silico investigations on macromolecule binding affinity and modulatory effects.
Department of Biotechnology, St. Mary's College (Autonomous), Thrissur, 680020, Kerala, India.
Department of Biotechnology, PSG College of Arts & Science, Coimbatore, 641014, Tamil Nadu, India.
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India. lavanyakube93@gmail.com.
Retraction Note: Letter to the Editor: Efficacy of subthalamic deep brain stimulation programming strategies for gait disorders in Parkinson's disease: A systematic review and meta-analysis .
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, USA. amritpalskooner@gmail.com.Chicago College of Osteopathic Medicine, Midwestern University, 555 31st St., Downers Grove, IL, 60515, USA. amritpalskooner@gmail.com.
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, USA.
Windsor University School of Medicine, St. Kitts, St. Kitts and Nevis.
A case-control comparison of pruritus and neurodegenerative disease: insights from comorbidities and demographic profiles.
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, USA. amritpalskooner@gmail.com.Chicago College of Osteopathic Medicine, 555 31st St, Downers Grove, IL, 60515, USA. amritpalskooner@gmail.com.
Windsor University School of Medicine, Cayon, Saint Kitts and Nevis.
College of Medicine, The University of Arizona, Tucson, AZ, USA.
A propensity scored case-control analysis of malignant skin cancers and chronic inflammatory disorders.
Association of alopecia areata with psychiatric disorders: a case-control study in the All of Us research program.
Dyslipidaemia, characterised by abnormal lipid levels in the blood, is an important risk factor for cardiovascular disease. In this case-control study, the association between single-nucleotide polymorphisms in ERBB2 and ERBB3 genes and the risk of dyslipidaemia in a population from Northern Anhui, China was evaluated. Particularly, we analysed samples from 543 patients with dyslipidaemia and 648 healthy controls for five potentially functional polymorphisms using TaqMan assays. Multivariate logistic regression was used to assess the relationship between genotype and dyslipidaemia, adjusting for confounding variables. The ERBB2 rs2517955 and rs1058808 single-nucleotide polymorphisms were significantly associated with dyslipidaemia. The rs2517955 variant showed a protective effect against dyslipidaemia in males, individuals aged 55 years or younger, and those without diabetes. Similarly, the rs1058808 variant decreased the risk of dyslipidaemia in these stratified groups. Conversely, ERBB3 rs2292238 was associated with an increased risk of dyslipidaemia in patients with diabetes. Compared with the corresponding wild-type alleles, variant alleles of rs2517955 and rs1058808 were associated with a reduced risk of decreased high-density lipoprotein cholesterol levels. Additionally, ERBB2 rs2517955 variants were significantly linked to total cholesterol levels, whereas ERBB3 rs3741499 and rs877636 variants were significantly associated with low-density lipoprotein cholesterol levels. Our findings suggest that ERBB2 and ERBB3 polymorphisms are closely associated with the risk of dyslipidaemia in the Chinese population. These results provide valuable insights for further genetic studies of dyslipidaemia and the identification of potential therapeutic targets.
Department of Epidemiology and Health Statistics, School of Public Health, Institute of Chronic Disease Prevention and Control, Wannan Medical College, No. 22 Wenchang Road, Wuhu, 241002, Anhui, China.
Department of Clinical Medicine, Anhui College of Traditional Chinese Medicine, Wuhu, 241003, China.
School of Medicine, Taizhou University, Taizhou, 318000, China.
Department of Epidemiology and Health Statistics, School of Public Health, Institute of Chronic Disease Prevention and Control, Wannan Medical College, No. 22 Wenchang Road, Wuhu, 241002, Anhui, China. jinyl0803@wnmc.edu.cn.
Department of Epidemiology and Health Statistics, School of Public Health, Institute of Chronic Disease Prevention and Control, Wannan Medical College, No. 22 Wenchang Road, Wuhu, 241002, Anhui, China. chenyan2010@wnmc.edu.cn.
Department of Epidemiology and Health Statistics, School of Public Health, Institute of Chronic Disease Prevention and Control, Wannan Medical College, No. 22 Wenchang Road, Wuhu, 241002, Anhui, China. yaoyingshui@wnmc.edu.cn.
Association Between ERBB2 and ERBB3 Polymorphisms and Dyslipidaemia and Serum Lipid Levels in a Chinese Population.
Autism spectrum disorder is characterized by restricted and repetitive behaviors or interests, emotional difficulties, and challenges with social communication. Technological tools are crucial for individuals on the autism spectrum as they offer predictable environments free of social demands. Mobile smartphones are particularly suitable for individuals on the autism spectrum due to their attractive screens, visually stimulating displays, high portability, engaging music and game functions, and ease of use. This study investigated the current market situation for game-based mobile applications designed to teach socio-emotional skills to individuals on the autism spectrum. This study focused on identifying game-based mobile applications available on Android and iOS platforms, evaluating the extracted serious games using a serious games assessment tool, and assessing the apps with the Mobile Application Rating Scale (MARS). We also provided suggestions for future designs. 10 applications were identified on the Android and iOS. At first glance, it seems there are several game-based applications for teaching socio-emotional skills to individuals on the autism spectrum, but most of them contain advice and textual information and lack the main aspects of serious games. On average, the design of the selected applications based on the use of serious game design principles can be classified as good. Additionally, more than half of the apps (70%) received an acceptable MARS score. The findings reveal that few apps meet the predetermined criteria for quality, content, or performance, indicating a need for future designs to adhere to these principles.
Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Rashid Yasmi St, Tehran, Iran.
Family Research Institute, Shahid Beheshti University, Tehran, Iran.
Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Rashid Yasmi St, Tehran, Iran. nasiri.so@iums.ac.ir.
Journal of autism and developmental disorders
Evaluating Free Serious Game-Based Apps for Teaching Socio-Emotional Skills to Individuals on the Autism Spectrum: A Systematic Review of the Smartphone Markets.
The present work investigates, for the first time, the synthesis of a composite film based on glutaraldehyde-cross-linked chitosan (GA-CS) and a natural zeolite (H-ZSM-5) and its application for the removal of hexavalent chromium (Cr(VI)) from aqueous solutions under wide experimental conditions. The composite film (GA-CS-ZEO) characterization by using various analytical techniques confirms its successful production with promising physical, chemical, and thermal properties. The use of the response surface methodology (RSM) for the optimization of the Cr(VI) adsorption by this composite shows that that the maximum removal efficiency (82.39%) was achieved for a Cr(VI) concentration of 50 mg L-1, an initial pH of 2.0, a contact time of 100 min, and a temperature of 20 °C. Moreover, the analysis of variance (ANOVA) and 3D graphs indicated that the pH and initial Cr(VI) concentration were the main factors that influence the Cr(VI) uptake efficiency. Besides that, the Cr(VI) removal by the GA-CS-ZEO was found to be spontaneous and endothermic and occurs mainly via physical mechanisms involving electrostatic interactions and hydrogen bonding. Regeneration study of the Cr(VI)-loaded composite showed that Cr(VI) can be rapidly and efficiently desorbed by 0.1 M sulfuric acid. The results of the current research work highlight the important adsorption potential of Cr(VI) by the GA-CS-ZEO composite film and underscore its attractiveness and suitability for water treatment applications.
Laboratory of Advanced Materials and Physico-Chemistry for Environment and Health, Faculty of Exact Sciences, Djillali Liabes University, 22000, Sidi Bel Abbes, Algeria.
Center for Environmental Studies and Research, Sultan Qaboos University, Muscat, Oman. s.jelali@squ.edu.om.
Laboratory of Advanced Materials and Physico-Chemistry for Environment and Health, Faculty of Exact Sciences, Djillali Liabes University, 22000, Sidi Bel Abbes, Algeria.Scientific and Technical Research Center in Physico-Chemical Analysis, CRAPC, Tipaza, Algeria.Laboratory of Structure, Development and Application of Molecular Materials (SEA2M), Faculty of Exact Sciences and Computer Science, Abdelhamid Benbadis University, Mostaganem, Algeria.
National Higher School of Nanosciences and Nanotechnologies, Sidi Abdellah, Algiers, Algeria.
Laboratory of Chemistry of Materials (LCM), University of Oran, 1 Ahmed Ben Bella, Oran, Algeria.Higher School of Applied Sciences, P.O. Box 165 RP, 13000, Tlemcen, Algeria.
Laboratory of Organic Chemistry, Physics, and Macromolecules, Faculty of Exact Sciences, Djillali Liabes University, 22000, Sidi Bel Abbes, Algeria.
The Institute of Materials Science of Mulhouse (IS2M), University of Haute Alsace, University of Strasbourg, CNRS, UMR 7361, F-68100, Mulhouse, France.
Environmental science and pollution research international
Environ Sci Pollut Res Int. 2025-02-08;():.
Cross-linked chitosan/H-ZSM-5 zeolite composite film for chromium removal from aqueous solutions: optimization using response surface methodology and adsorption mechanism assessment.
Vitiligo is a depigmentation disease caused by the targeted destruction of melanocytes, resulting in skin and hair depigmentation and significant psychological stress. However, the mechanisms underlying its onset and progression remain unclear. Endoplasmic reticulum (ER) stress, which is linked with oxidative stress and autoimmunity, is involved in the development of vitiligo, and prolonged ER stress induces apoptosis. Sirtuin 1 (Sirt1) might be a key regulator of ER stress. Thus, we explored how Sirt1 modulates ER stress-induced melanocyte apoptosis in vitro and in vivo. Our results showed that Sirt1 affected ER stress-induced apoptosis of melanocyte apoptosis when upon to ER stress in vitro. Sirt1 inhibition aggravated the vitiligo phenotype in mice; thereby protecting against the stress response, and abating the unfolded protein response. These results suggest that Sirt1 impairment could accelerate melanocyte apoptosis in vitiligo.
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.12 Jiangwangmiao, Xuanwu District, Nanjing, 210042, Jiangsu, China.
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.12 Jiangwangmiao, Xuanwu District, Nanjing, 210042, Jiangsu, China.Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.12 Jiangwangmiao, Xuanwu District, Nanjing, 210042, Jiangsu, China. dr_lcr72@163.com.
Sirtuin1 Deficiency Could Exacerbate Melanocyte Apoptosis Under Endoplasmic Reticulum Stress.
This systematic literature review aims to list the validated tools measuring work-related psychosocial factors (WRPFs) influence health care workers' (HCWs) sickness absence (SA), and to evaluate their psychometric and practical properties.Using the PsycINFO, Medline, and Web of Science databases, the search targeted prospective studies on WRPFs and SA in HCWs published between 2012 and 2023. The validated, self-report tools that measured WRPFs and that yielded at least one significant predictor of SA in HCWs were identified. An evaluation of the psychometric and practical properties was performed.Based on inclusion criteria, three prospective studies on HCWs were included, and twelve tools were listed. Psychometric and practical properties were excellent for six tools, good for four, and questionable for two.Researchers and occupational health practitioners can use tools with good to excellent overall quality to measure traditional WRPFs that predict SA in HCWs. There is a need to develop and validate tools that measure WRPFs representing the specific characteristics of the health care working environment. Other WRPFs relevant to the work context of HCWs can be measured by extant tools that could be used in research and program development and evaluation.
Institut de recherche Robert-Sauvé en santé et en sécurité du Travail, 505, Boul. De Maisonneuve Ouest, Montreal, QC, H3A 3C2, Canada. laurent.corthesy-blondin@irsst.qc.ca.Centre de recherche de l'Institut universitaire de santé mentale de Montréal, Montreal, Canada. laurent.corthesy-blondin@irsst.qc.ca.
Department of Psychology, University of Milan-Bicocca, Milan, Italy.
Institut de recherche Robert-Sauvé en santé et en sécurité du Travail, 505, Boul. De Maisonneuve Ouest, Montreal, QC, H3A 3C2, Canada.
Institut de recherche Robert-Sauvé en santé et en sécurité du Travail, 505, Boul. De Maisonneuve Ouest, Montreal, QC, H3A 3C2, Canada.Centre de recherche de l'Institut universitaire de santé mentale de Montréal, Montreal, Canada.
A Systematic Review and Evaluation of the Tools Measuring Work-Related Psychosocial Factors in Prospective Research on Sickness Absence of Health Care Workers.
Cervical cancer is the fourth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in women globally. Recent advances in immunotherapy have demonstrated promising results. This study analyses the real-world impact of adding immunotherapy for patients with stage IV cervical carcinoma.This longitudinal retrospective observational study included patients with stage IV cervical carcinoma in the first metastatic setting treated between 2010 and 2023 at the University Hospital Nuestra Señora de Candelaria in Tenerife, Spain. To evaluate the primary objective, patients were divided into two groups depending on whether they had received immunotherapy with pembrolizumab or not. The primary endpoint was 12-month progression-free survival in patients receiving immunotherapy compared to those not receiving it.A total of 56 patients were analyzed, of whom 31 were tested for PD-L1. Among those tested, 25 patients (84%) were PD-L1 positive, and 18 of them (72%) received immunotherapy. The objective response rate was significantly higher, being 94% in the group that received immunotherapy, compared to 32% in the group that did not (p < 0.001). At 12 months, the cumulative probability of progression-free survival was estimated at 94.4% for the immunotherapy group versus 59.7% in the non-immunotherapy group (p = 0.009), with a hazard ratio of 0.116 (CI95%: 0015 - 0.883; p = 0.038). Immunotherapy alone or combined with bevacizumab showed similar progression-free survival probabilities. However, these outcomes were significantly different when compared to patients who received neither therapy (p < 0.001).Our findings confirm that immunotherapy significantly improves progression-free survival and objective response rates in metastatic cervical carcinoma, aligning with the results from the KEYNOTE-826 trial. The implementation of PD-L1 testing and the addition of immunotherapy whenever possible are challenges to be achieved in clinical practice.
Department of Medical Oncology, Immuno-Oncology Unit, Lausanne University Hospital, Lausanne, Switzerland. ana-isabel.martin-quesada@chuv.ch.
Clinical Epidemiologist Department of Clinical Epidemiology and Biostatistics, Research Unit, University Hospital Nuestra Señora de Candelaria and Primary Care Management, Santa Cruz de Tenerife, Spain.Networked Biomedical Research Centre (CIBER) of Respiratory Diseases, Carlos III Health Institute, Madrid, Spain.
Medical Oncology Department, University Hospital Nuestra Señora de Candelaria, Carretera General del Rosario 145, 38010, Santa Cruz de Tenerife, Spain. natalia.perezrodriguez@gmail.com.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Evaluating the benefits of immunotherapy in metastatic cervical cancer: an observational retrospective analysis.
Patient visitor restrictions were implemented in unprecedented ways during the COVID-19 pandemic and included bans on any visitors to dying patients and bans separating mothers from infants. These were implemented without high quality evidence they would be beneficial and the harms to patients, families and medical personnel were often immediately clear. Evidence has also accumulated finding strict visitor restrictions were accompanied by long-term individual and societal consequences. We highlight numerous examples of restrictions that were enacted during the COVID-19 pandemic, including some that continue to be in place today. We outline six specific concerns about the nature and effects of the visitor restrictions seen during the COVID-19 pandemic. These considerations may help provide both an ethical and science-based framework, through which healthcare workers, families and government entities can work towards safeguarding patient and family rights and well-being.
Sloan School of Management, Massachusetts Institute of Technology, Office E62-562. 100 Main St., Cambridge, MA, 02142, USA. tbhoeg@mit.edu.Department of Clinical Research, University of Southern Denmark, Odense, Denmark. tbhoeg@mit.edu.Department of Emergency Medicine, University of California-San Francisco, San Francisco, USA. tbhoeg@mit.edu.
George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, USA.
Lessons from COVID-19 patient visitation restrictions: six considerations to help develop ethical patient visitor policies.
Osteoarthritis (OA) is a prevalent, debilitating ailment among the elderly. Humans need a correct sagittal spino-pelvis-lower extremity alignment to stand upright. Pathology in trunk or lower extremity section might disrupt this harmony, causing compensatory alterations in other segments. The aim of the present study was to evaluate spino-pelvis-lower extremity alignment and association among the various spino-pelvic, knee, and ankle radiological angles in patients with knee osteoarthritis (OA).This prospective study enrolled 70 adults over 50 years of age of either sex who complained of knee pain and met the American College of Rheumatology criteria for symptomatic OA of at least one knee. The radiological assessment comprised anteroposterior and lateral lower extremity full-length scans, as well as the Kellgren-Lawrence radiographic classification of OA. We measured hip, knee, ankle, and spino-pelvic angles using Horos software. We calculated descriptive statistics and linear correlation between continuous variables.There was a significant association (p < 0.05) between age and the majority of the spino-pelvic, knee, and ankle angles and between age and severity of OA. Significant variables linked with 'SFA' include HKAA (p = 0.008), mLDFA (p < 0.001), TJLA, FS-TS, Cond-Plateau, and femoral bowing (p = 0.007). We found significant associations between 'PFA' and mMPTA (p = 0.005), Cond-Plateau (p = 0.005), Tibial Bowing (p = 0.003), and 'LL' with HKAA, mLDFA, FS-TS, and Cond-Plate. SSA was significantly associated with mLDFA, mMPTA, TJLA, Cond-Plateau, and HKAA; while, FI' was significantly associated with FS-TS, femoral bowing, and tibial bowing (p < 0.001). The variables 'SS' was substantially linked with TTA (p = 0.008), TT (p = 0.004), PP (< 0.001), GP (p < 0.001), and GT (p = 0.010). 'PI' was substantially linked to TT (p = 0.001), GP (p = 0.005), and GT (p = 0.042), and 'PT' to TT (p < 0.001) and GT (p = 0.012). 'SFA' and 'PFA' only correlated with TT (p = 0.012 and 0.010). Lower limb angles were significantly associated with TT, PP, GP, GT, mLDFA, and mMPTA (p = 0.031, p = 0.026, p = 0.009, p = 0.009, TT, GP, GT, p < 0.001). GP was the sole significant association for 'TJLA' (p = 0.016). 'FS-TS' substantially correlated with PP (p = 0.015), GP (p < 0.001), and GT (p < 0.001). Femoral Bowing was significantly linked to PP (p = 0.017), GP (p = 0.007), and GT (p < 0.001), and Cond-Plateau was significantly linked to GP (p = 0.002) and GT. Tibial Bowing was significantly linked to TTA (p < 0.001), TAS (p = 0.003), LDTA (p = 0.002), TC (p < 0.001), GP (p = 0.007), and GT (p < 0.001). Age, gender, BMI, and the severity of knee OA significantly influenced the association among these various angles.Osteoarthritis of the knee disrupts the harmonious alignment of the spine and pelvis with the lower limbs, resulting in compensatory changes in the ankle and spine. The severity of knee osteoarthritis and the patient's gender, age, and BMI impact compensatory adaptations.CTRI/2021/08/036088 [Registered on: 31/08/2021] - Trial Registered Prospectively.
© 2025. The Author(s), under exclusive licence to Istituto Ortopedico Rizzoli.
Department of Orthopaedic Surgery, Paraplegia & Rehabilitation, Pt. B.D. Sharma PGIMS, 52/9-J, Medical Enclave, Rohtak, 124001, Haryana, India. drroopsingh@rediffmail.com.
All India Institute of Medical Sciences, New Delhi, India.
Department of Radiodiagnosis and Imaging, Pt. B.D. Sharma PGIMS, Rohtak, 124001, Haryana, India.
Baba Saheb Ambedkar Medical College, Rohini, New Delhi, India.
All India Institute of Medical Sciences, Bhubaneswar, India.
Changes in spino-pelvis-lower extremity alignment in patients with knee osteoarthritis: a prospective radiographic study.
Aberrant activation of the Wnt/β-catenin signaling pathway, primarily driven by APC mutation and AXIN degradation via Tankyrase, contributes significantly to colorectal cancer (CRC) progression and metastasis. The accumulation of β-catenin, resulting from the dysregulated ubiquitination, underscores the need for alternative therapeutic strategies targeting Tankyrase and β-catenin. This present study explores microbial metabolites as a source of novel anti-cancer agents, leveraging their unique bioactivity and structural diversity, often exhibiting superior target specificity and lower toxicity than synthetic drugs. Through a computational drug discovery pipeline, a large library of 27641 microbial metabolites was initially screened based on multiple drug-likeliness criteria, resulting in the selection of 2527 compounds. Among the screened compounds, an integrated computational workflow comprising molecular docking, molecular dynamic simulations (MDS), MM/PBSA analysis, and Principal component analysis (PCA) identified Terreustoxin I (T1) as a potential Tankyrase inhibitor. In contrast, compound 10- phenyl-[12]-cytochalasin Z16 (B1) demonstrated a strong binding affinity within the β-catenin active site. Under physiological conditions, these lead compounds were evaluated for conformational stability, binding efficacy, and dynamic behavior. Additionally, ADMET profiling, physiochemical properties, and bioactivity score predictions confirmed the identified compounds' pharmacokinetic suitability and reduced toxicity profile. In silico, cytotoxicity predictions showed significant activity against SW480 and HCT90 colorectal cell lines, with additional anti-neoplastic and anti-leukemic properties, strengthening their candidacy as effective anti-cancer agents. These findings provide a foundation for further experimental validation and development of novel CRC therapies with improved safety and efficacy potential.
© 2025. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. siva_kumar.a@vit.ac.in.
Pharmacophore-based identification and in Silico characterization of microbial metabolites as potential modulators of Wnt signaling pathway in colorectal cancer therapy.
Devoted Health, Waltham, Massachusetts, USA.
The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
MedExecinnovations, Phoenix, Arizona, USA.
University of Texas Health Science Center at Houston, Houston, Texas, USA.
Journal of the American Geriatrics Society
Team-Based Communication for Patient Health Priorities Within a Home-Based Program.
Identifying metabolites produced by probiotic bacteria, also known as metabiotics, is becoming increasingly common due to their anti-inflammatory, anti-obesogenic, and immunomodulatory effects. Postbiotics alongside diet, regulate both physical and mental health, as the microbiota members can interact physically with host cells or through secretion of nutrients and metabiotics. These metabiotics also reduce the severity of certain metabolic disorders and support the proper functioning of various organs and systems. In this review, we describe the mechanisms of action of trans-vaccenic acid (TVA), indole-3-lactic acid (ILA), thiamine (vitamin B1), and butyric acid metabolites produced or induced by probiotics such as Lactobacillus and/or Bifidobacterium, among others and previously identified using analytical techniques such as mass spectrometry (LC-MS). Within their mechanisms of action, Trans-vaccenic acid exerts anti-inflammatory effects and helps alleviate complications associated with metabolic diseases. Indole metabolites promote IL-22 production and regulate epithelial cell proliferation and antimicrobial peptide production. Thiamin is essential for energy metabolism regulation, and butyric acid regulates the brain-gut axis and also regulates immune response. This review expands our understanding of the potential therapeutic use of metabiotics.
Laboratory of Medical and Pharmaceutical Biotechnology, Faculty of Biotechnology, Popular and Autonomous, University of the State of Puebla (UPAEP), 72410, Puebla, Mexico.Department of Sciences and Engineering, Iberoamerican Puebla University, 71820, Puebla, Mexico.
Laboratory of Medical and Pharmaceutical Biotechnology, Faculty of Biotechnology, Popular and Autonomous, University of the State of Puebla (UPAEP), 72410, Puebla, Mexico. eli.bautista@gmail.com.Clinical Chemistry, Faculty of Health Sciences, Autonomous University of Tlaxcala, 90750, Tlaxcala, Mexico. eli.bautista@gmail.com.
Department of Sciences and Engineering, Iberoamerican Puebla University, 71820, Puebla, Mexico.
Healthy Aging Laboratory of the National Institute of Genomic Medicine (INMEGEN) at the Aging Research Center (CIE-CINVESTAV), 14330, CDMX, Mexico.
Faculty of Health Sciences, Autonomous University of Tlaxcala. Tlaxcala, 90750, Medicine, Mexico.Health Research Office, State Coordination of the Mexican Social Security Institute (IMSS-BIENESTAR), Tlaxcala, Mexico.
Faculty of Chemical-Biological Sciences, Autonomous University of Campeche, 24039, Campeche, Mexico.
Probiotics Antimicrob Proteins. 2025-02-08;():.
Mechanisms and Therapeutic Potential of Key Anti-inflammatory Metabiotics: Trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid.
Obesity, a chronic disease with pandemic proportions, is recognized as a major risk factor for cardiometabolic disorders due to its association with atherogenic dyslipidemia, a common characteristic attributed to visceral adiposity in patients with obesity. Atherogenic and visceral-obesity indices have been conceded as surrogate cardiovascular diseases (CVD) indicators surpassing the conventional markers due to stronger predictive power for obesity-induced cardiometabolic risk and CVD mortality rate. Nutraceuticals have been suggested as emerging approaches to counteract obesity-associated cardiometabolic disorders. Considering the evidence addressing the ameliorating effects of either L-carnitine or biotics on metabolic indices, also the reports addressing higher efficacy of concomitant supplementation versus single-therapies, this clinical trial was conducted to assess the effects of L-carnitine + multi-species/multi-strain synbiotic combined supplementation compared to L-carnitine mono-therapy on atherogenic-indices, body composition, visceral obesity, and appetite sensations in 46 metabolically healthy women with obesity, randomly assigned to co-supplementation (L-carnitine-tartrate (2 × 500 mg/dl) + synbiotic (one capsule/day)) or mono-therapy (L-carnitine-tartrate (2 × 500 mg/dl) + maltodextrin (one capsule/day)) groups for 8 weeks. L-carnitine + synbiotic co-supplementation led to a significantly greater reduction in atherogenic-indices including atherogenic-index-of-plasma (AIP), Castelli's-risk-index-I (CRI-I), Castelli's-risk-index-II (CRI-II), atherogenic-coefficient (AC), lipoprotein-combine index (LCI), systolic blood pressure (SBP), fat-mass (FM) weight/percent, visceral-adiposity index (VAI), waste-to-height ratio (WHtR), body-adiposity index (BAI), and appetite sensation scores compared to L-carnitine mono-therapy. L-carnitine + synbiotic combined supplementation was more efficient in improving atherogenic-indices as cardiovascular risk markers, body composition, visceral obesity, and appetite sensations in metabolically healthy women with obesity. Therefore, simultaneous supplementation of L-carnitine + synbiotic might be considered a promising approach to ameliorate cardiometabolic risk factors in healthy individuals with obesity. Further longer period studies are required to confirm these findings. (Iranian Registry of Clinical Trials (IRCT; https://irct.behdasht.gov.ir/trial/28048 ).
Student Research Committee, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. mahdavir@tbzmed.ac.ir.
Modulatory Effects of Multi-species/Multi-strain Synbiotic and L-carnitine Concomitant Supplementation on Atherogenic-Indices, Body Composition, Visceral Obesity, and Appetite in Metabolically Healthy Women with Obesity: A Double-Blind Randomized Controlled Clinical Trial.
Influenza A virus (IAV) remains a significant public health concern due to its annual epidemics and potential for global pandemics. Despite the availability of countermeasures such as vaccines and antiviral treatments, their effectiveness is often questioned due to the emergence of novel strains with antiviral resistance and the variable efficacy of influenza vaccines compared to other vaccines. Traditionally, influenza vaccination strategies have focused on matrix, neuraminidase, and nucleoproteins. In this study, considering the crucial roles of HA and RdRp (PA, PB1, and PB2) of Influenza A, a reverse vaccinology approach is put forth in designing a possible promising antigenic protein toward the development of vaccines against H1N1 viruses. With the development of immunoinformatics approach, one can design/construct potential candidates for vaccine formulation against IAV with the epitope segments identified based on B- and T-cell recognition linked via adjuvants like EAAAK, GPGPG, and AAY linkers. Computational assessments of physicochemical properties, antigenicity, immunogenicity, allergenicity, and toxicity predictions, conducted to evaluate the potential of designed vaccine construct, indicated high antigenicity and potential interactions with immune receptors. Molecular docking of the vaccine construct with human immune receptors (MHCI, MHCII, TLR4, TLR7, and TLR8) followed by molecular dynamics simulations demonstrated stable dynamics with strong binding affinity. The computational immune response modeling with multiple dosages suggested significant immune activation by this construct against IAV. In essence, these findings highlight the potential immune property of the vaccine construct, and put forth the need of thorough preclinical assessments in transforming this construct as a vaccine against the challenging IAV pathogens.
Department of Bioinformatics, Pondicherry University, Puducherry, 605014, India.Directorate of Medical Research, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation, Puducherry, 607402, India.
Department of Bioinformatics, Pondicherry University, Puducherry, 605014, India.
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, 208016, India.
Department of Biotechnology, M. S. Ramaiah Institute of Technology, Bengaluru, Karnataka, 560054, India.
Department of Bioinformatics, Pondicherry University, Puducherry, 605014, India. ramutha@bicpu.edu.in.
Designing a multi-epitope vaccine candidate against pandemic influenza a virus: an immunoinformatics and structural vaccinology approach.
The goal of the current study was to examine the links between academic stress, maternal support, and three different forms of prosocial behaviors (i.e. in-group prosocial behaviors, out-group prosocial behaviors, and civic engagement). Additionally, we also examined the interactive effect between academic stress and maternal support on prosocial behaviors. Participants were 142 young adult college students (M age = 20.82 years; range = 18-25 years; 81.7% women; 65.2% reported identifying as racially White; 9.9% Black; 7.8% Asian; 5.7% Native; and 49.3% identified their ethnicity as Latino/a). Participants reported on their academic stress levels, perceptions of their maternal support, and their tendencies to engage in the three forms of prosocial behaviors. The results (see Figure 1) demonstrated that academic stress was not associated with prosocial outcomes. Maternal support was positively associated with in-group prosocial behaviors. There was also one significant interaction that emerged. The interaction between academic stress and maternal support positively predicted civic engagement, such that when maternal support was low, academic stress was positively associated with civic engagement. The discussion focuses on the nuanced associations between these variables, with a focus on the potentially protective role of civic engagement specifically for young adults seeking social connection and belonging.
Department of Individual, Family and Community Education, University of New Mexico, Albuquerque, New Mexico, USA.
Department of Special Education, University of New Mexico, Denton, Texas, USA.
Links Between Academic Stress and Prosocial Outcomes: The Moderating Role of Maternal Support.
Recent interest in leveraging external data for clinical trial design and analysis in glioblastoma has raised questions on the identification of appropriate data to use as external controls for future trials. We perform a comprehensive analysis assessing candidate sources of external data and comparing clinical trial and real-world datasets in newly diagnosed glioblastoma.Individual patient-level data (PLD) from several clinical trials, a large academic institutional database and a registry (National Cancer Database) were used for analysis of patients receiving standard of care radiation with concurrent and adjuvant temozolomide. Data summaries from randomized trials 2012-2022 were analyzed to account for trials without available PLD. Multivariable modeling was employed to compare survival across datasets.In total, 8 datasets with PLD for 3061 patients with newly diagnosed glioblastoma treated with standard chemoradiation were analyzed. Patients on trials were younger (age<60:64% vs. 48%,p<0.001) and had higher KPS (KPS>90:58% vs. 48%,p<0.001) compared to non-trial patients. Patients in clinical trials exhibited inferior survival relative to non-trial patients (HR 1.30,95%CI 1.13-1.48,p<0.001) after adjustment for age, sex, KPS, extent of resection and MGMT methylation status. In assessment of data summaries of 19 randomized trials, there was no detectable time-trend toward improved outcomes 2012-2022.In newly diagnosed glioblastoma patients treated with standard of care chemoradiation, there were significant differences between trial datasets and real-world datasets but no evidence of a trial effect benefit from trial participation. After adjustment of relevant covariates, there was no evidence of temporal drift of improved survival over the last decade.
© The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Division of Biostatistics & Health Data Science, University of Minnesota, Minneapolis, USA.
Department of Data Sciences, Dana-Farber Cancer Institute, Boston, USA.
Kirk Tanner, PhD. National Brain Tumor Society, Newton, USA.
Patrick Y. Wen, MD (Professor). Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
Lorenzo Trippa, PhD. Department of Data Sciences, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, USA.
Identifying appropriate external control datasets in support of future glioblastoma clinical trials leveraging external data.
Unhealthy sleep and secondhand smoke (SHS) exposure are independent risk factors for death. Their joint association with all-cause and cardiovascular disease (CVD) mortality (ACDM) deserves to be investigated in a nationally representative population.Data from 15175 adults from the National Health and Nutrition Examination Survey database (2005-2014) were analyzed. The study endpoints were all-cause and CVD mortality. Sleep patterns (healthy, intermediate, and poor) were classified based on self-reported questionnaires, including sleep duration, self-reported trouble sleeping and doctor-diagnosed sleep disorders. SHS exposure among nonsmokers was defined according to cotinine levels in serum. Multivariate Cox hazards regression models were conducted to assess the association between sleep patterns and SHS exposure, alone and in combination, with ACDM.During 15 years of follow-up, 2016 all-cause deaths and 678 CVD deaths were recorded. In multivariable models, poor sleep was independently associated with higher risk of all-cause (hazard ratio [HR] 1.32; 95% confidence interval [CI] 1.15-1.51) and CVD mortality (HR= 1.31; 95% CI: 1.02-1.68). Exposure to SHS was associated with higher risk of all-cause (HR, 1.21; 95% CI, 1.08-1.36) and CVD mortality (HR, 1.25; 95% CI, 1.04-1.50). In the joint analyses, participants with both unhealthy sleep patterns (intermediate and poor) and SHS exposure had a significantly higher risk of all-cause (HR, 1.48; 95% CI: 1.26-1.74) and CVD mortality (HR, 1.51; 95% CI, 1.15-1.97) than those with neither risk factor.The coexistence of SHS exposure and unhealthy sleep patterns was associated with an increased risk of death from all causes and CVD.The findings of this study indicate that both poor sleep patterns and exposure to SHS are independently associated with a higher risk of all-cause and CVD mortality. Furthermore, the coexistence of SHS exposure and unhealthy sleep patterns further increases the risk of mortality from all causes and CVD. Since both sleep patterns and SHS exposure are modifiable factors, interventions aimed at reducing SHS exposure and improving sleep quality could have significant implications in reducing these adverse effects and lowering mortality risk.
Respiratory and Critical Care Department, the First Hospital of China Medical University, Shenyang, China.
Joint effect of sleep patterns and secondhand smoke exposure with mortality among non-smoking adults.
Climate change poses a growing threat to population maintenance in harsh desert habitats with high precipitation variability. Desert seeds may germinate at different times as a bet-hedging strategy to cope with increased rainfall fluctuation. As a result, a population may consist of seedlings of various sizes. However, it remains unknown how the variation in seedling sizes affects their capacity to cope with different rainfall scenarios, thus impairing our capacity to manage population under climate change.To fill this gap in knowledge, we examined how seedling size (large seedlings with an average height of 14.30 cm vs. small seedlings with an average height of 5.85 cm) affects the strategy seedlings use to cope with a gradient of rainfall treatments (-75%, -50%, -25%, 0%, +25%, +50%, +75%) for Artemisia ordosica Krasch., a dominant shrub widely used for ecological restoration in the Mu Us Sandland.We found that seedling performance was affected both by rainfall intensity and seedling size. Seedling survival and growth declined with reduction in rainfall. Moreover, large seedlings allocated more biomass to roots, thus increasing their capacity for water absorption, resulting in relatively less reduction in their total biomass under water stress. In contrast, small seedlings invested more in aboveground growth, likely to compete for light.Our study demonstrates that seedling size may strongly affect the responses of seedlings to rainfall variation. As a result, populations having recruitment of seedlings with different sizes may better spread mortality risk under variable rainfall conditions. Therefore, our results suggest that species with flexible germination time may be highly suitable for desert vegetation restoration under climate change.
State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems, Center for Grassland Microbiome, and College of Pastoral, Agriculture Science and Technology, Lanzhou University, Lanzhou, 730000, Gansu, China.
Department of Biology, The Pennsylvania State University, University Park, PA, USA.
Department of Biology, South Parks Road, University of Oxford, Oxford, UK.School of Biological Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen, UK.
Seedling size affects the strategy of dune seedlings responding to rainfall variation.
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Pitzer College & Claremont Graduate University, Claremont, California, USA.
Department of Psychology, Florida International University, Miami, Florida, USA.
Infancy : the official journal of the International Society on Infant Studies
Introduction to the Special Issue on Developmental Plasticity in Early Human Development.
Internal Medicine, Trinity Health Ann Arbor, Ann Arbor, MI, USA.
Division of Rheumatology, Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, USA, MI.
Division of Rheumatology, Children's National Hospital, Washington, DC, USA.
Department of Pediatrics, School of Medicine, George Washington University, Washington, DC, USA.
Comment on: Risk factors of COVID-19 related hospitalization of pediatric patients with rheumatic diseases: a systematic review and meta-analysis: Reply.
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.Afghanistan Center for Epidemiological Studies, Herat, Afghanistan.
Department of Paediatrics, Dr D. Y. Patil Medical College Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, India.Department of Public Health Dentistry, Dr D. Y. Patil Medical College Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra, India.
Comment on: Risk factors of COVID-19 related hospitalization of pediatric patients with rheumatic diseases: a systematic review and meta-analysis.
Flat 6 Souchay Court, 1 Clothorn road, Manchester, M20 6BR.
What we look for might be the wrong answer.
International Journal of Pharmceutical Compounding
International journal of pharmaceutical compounding
Standard Operating Procedure: Calculating the Endotoxin Load in Compounded Sterile Preparations.
Compounded GLP-1 Drugs and Patient Adverse Events.
Best Practices for Marketing Compounded Medications.
Medicina Familiar y Comunitaria, ZBS Torreperojil, Sabiote, Jaén, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
Medicina Familiar y Comunitaria, ZBS Trujillo, Herguijuela y Conquista de la Sierra, Cáceres, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
Medicina Familiar y Comunitaria, ZBS Ontinyent, Fontanars dels Alforins, Valencia, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024. Electronic address: rmicop@semergen.es.
Medicina Familiar y Comunitaria, Granada, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
Medicina Familiar y Comunitaria, CS Vallobín-La Florida, Oviedo, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
Medicina Familiar y Comunitaria, Motril San Antonio del AGS de Granada, Granada, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
Medicina Familiar y Comunitaria. Casas del Monte. EAP Aldeanueva del Camino, Aldeanueva del Camino, Cáceres, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
Medicina Familiar y Comunitaria. Servicio de urgencias de Atención Primaria, Miera, Cantabria, España; Miembro del Comité Organizador y Científico del 4.° Congreso de Medicina rural SEMERGEN, Úbeda, 5-6 de abril de 2024.
[The strategic value of rural medicine: Declaration of Úbeda].
Elongation (ELG) method-based property optimization (POPT) is an effective approach for designing large systems from one terminal to the other. An alternating multi-directional ELG method is introduced to enable alternating POPT for complex systems with multiple growth directions, improving efficiency. (Hyper)polarizabilities of donor-acceptor-substituted polydiacetylenes (PDAs) aligned along the z $$ z $$ -axis are optimized by alternating POPT, where donor- and acceptor-substituted diacetylene monomers are alternately selected and attached to two PDA terminals. Alternating POPT's capability in designing systems with expected properties, efficiency, and accuracy has been validated. For n $$ n $$ types of donor and acceptor groups, the existing simultaneous ELG-based POPT requires calculating n 2 $$ {n}^2 $$ combinations, as monomers are simultaneously attached in both elongation directions. In contrast, the alternating ELG-based POPT only requires 2 n $$ 2n $$ combinations, halving the number of basis functions involved in calculations and significantly enhancing efficiency.
Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Fukuoka, Japan.
Department of Molecular and Material Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Fukuoka, Japan.
Elongation Method-Based Alternating Multi-Directional Automated Property Optimization Process and Its Application.
Aging is a physiological process resulting from the accumulation of molecular and cellular damage over time, leading to a gradual decline in overall physical and mental health. Throughout this temporal continuum, various physiological alterations occur in the organism, modifying the individual's response to multiple stimuli and adverse factors. At the same time, an increasingly significant manifestation of genetic modifications is observed, which are intrinsically interconnected with the dynamics of these adaptive processes. The geriatric population is characterized by its high prevalence in hospital settings, particularly in critical care units, where admissions from this group account for nearly 50% of total admissions. Thus, acquiring and updating knowledge is relevant and necessary to ensure a more effective therapeutic approach for geriatric patients.
Copyright © 2025 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.
Facultad de Medicina, Universidad Cooperativa de Colombia, Campus Pasto, Pasto, Nariño, Colombia. Electronic address: darkeio92@gmail.com.
Departamento de Ciencias Biomédicas y Básicas, Facultad de Odontología, Enfermería, Medicina, Universidad Cooperativa de Colombia, Campus Pasto, Pasto, Nariño, Colombia.
Departamento de Pediatría, Hospital Escuela César Amador Molina, Matagalpa, Nicaragua.
Facultad de Medicina, Universidad Cooperativa de Colombia, Campus Pasto, Pasto, Nariño, Colombia.
Grupo Interdisciplinario de Investigación en Salud-Enfermedad (GIISE), Facultad de Medicina, Universidad Cooperativa de Colombia, Pasto, Nariño, Colombia.
[Physiology of aging: An update and genetic point of view].
Metabolic syndrome (MS) is a pathological condition that encompasses various cardiometabolic risk factors, such as obesity, dyslipidemia, hyperglycemia, and elevated blood pressure levels. It is considered a multifactorial pathological condition. The aim of this study is to assess how variables such as age, sex, socioeconomic status, tobacco and alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress are associated with the prevalence of MS, determined using two different criteria.This is a descriptive, cross-sectional study conducted on 24,224 Spanish workers, evaluating the association between sociodemographic variables, health habits, and stress with MS, determined using two criteria: the National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP-III), and the International Diabetes Federation (IDF).All the variables analyzed showed an association with the presence of MS when applying both criteria. Among them, the variables with the strongest association were age: odds ratio 5.55 (95% CI: 4.80-6.30) for MS using the NCEP ATP-III criteria and 6.71 (95% CI: 5.30-8.13) for IDF criteria; and type of job: odds ratio 3.42 (95% CI: 2.95-3.90) for NCEP ATP-III and 3.57 (95% CI: 3.12-4.03) for IDF.The profile of an individual at higher risk of developing MS under both criteria would be an older male, manual laborer, smoker, habitual alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high levels of stress.
Grupo ADEMA-Salud del Instituto Universitario de Ciencias de la Salud (IUNICS) de Baleares, Palma, Islas Baleares, España; Facultad de Odontología, Escuela Universitaria ADEMA-UIB, Palma, Islas Baleares, España; Servicio de Salud de las Islas Baleares, España.
Grupo ADEMA-Salud del Instituto Universitario de Ciencias de la Salud (IUNICS) de Baleares, Palma, Islas Baleares, España; Facultad de Odontología, Escuela Universitaria ADEMA-UIB, Palma, Islas Baleares, España.
Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, España. Electronic address: pjtarraga@sescam.jccm.es.
Grupo ADEMA-Salud del Instituto Universitario de Ciencias de la Salud (IUNICS) de Baleares, Palma, Islas Baleares, España; Servicio de Salud de las Islas Baleares, España; Facultad de Medicina, Universidad de las Islas Baleares, Palma, Islas Baleares, España.
[Association between sociodemographic variables, healthy habits and stress with metabolic syndrome. A descriptive, cross-sectional study].
To examine nutritional status among patients with atrial fibrillation (AF) and its relationship with major adverse cardiovascular events (MACE), and to determine whether nutritional status is a risk factor for MACE in patients with AF.Observational, retrospective, community-based study (n=40,297) aged 65-95years in Terres de l'Ebre (Catalonia, Spain) between 2015 and 2021. A total of 2,574 patients with a diagnosis of AF were included. The CONUT scale was used to assess nutritional status and Cox regression analyses were performed.67.91% of AF patients developed MACE. Malnutrition as assessed by the CONUT scale was significantly higher in AF patients who developed MACE (P<.001). Malnutrition doubled the risk of MACE and was identified as a prognostic factor (HR: 1.06; 95%CI: 1.04-1.08; P<.001).Malnutrition is a prognostic factor for MACE in AF patients. Poorer nutritional status doubles the risk of MACE.
CSI Llíria, Departament de Salut de Arnau de Vilanova, Conselleria de Sanitat, Llíria, Valencia, España. Electronic address: pemolto@gmail.com.
EAP Tortosa Est, Terres de l'Ebre, Institut Català de la Salut, Grupo de Investigación Ebrictus, Unidad de Apoyo a la Investigación Terres de l'Ebre, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Tortosa, Tarragona, España.
Departamento de Enfermería, Grupo de Investigación en Enfermería Avanzada de la Universidad Rovira i Virgili, Programa de Doctorado en Biomedicina Campus Terres de l'Ebre, Tortosa, Tarragona, España.
CS Burriana I, Departament de Salut de La Plana, Conselleria de Sanitat, Burriana, Castellón, España.
Estudiante de Biotecnología, Universidad Católica de Valencia San Vicente Mártir, Valencia, España.
Psicóloga, logopeda y orientadora educativa, Valencia, España.
Doctorando en la Universidad de Valencia, Investigador pedagógico en AIJU, Valencia, España.
CS Delicias Norte (Zaragoza), Servicio Aragonés de Salud, Zaragoza, España.
[Poor nutrition status as a predictor of major adverse cardiovascular events (MACE) in patients with atrial fibrillation].
There is no doubt that lipoprotein(a) [Lp(a)] is a structurally complex molecule with unique biological functions. It plays an important role in the inflammatory process through multiple mechanisms, contributes to endothelial dysfunction, activation of monocytes, macrophages and proliferation of smooth muscle cells, and promotes the development of atherosclerotic cardiovascular disease (ASCVD). It is important to point out the complex bidirectional relationship between Lp(a) and inflammation, influencing one another and even exerting anti-inflammatory effects in certain situations. Likewise, Lp(a) can favor the development of heart valve disease, especially of the aortic valve. Numerous publications emphasize the need to determine Lp(a) levels in the population at least once in life and possible strategies to mitigate the risk of ASCVD generated by high Lp(a) levels. However, doubts or lack of knowledge persist about the need to measure this parameter, either due to the uncertainty of how to manage patients with high levels of Lp(a), due to insufficient knowledge about its physiological function or because its levels persist unchanged, to a large extent, throughout life as the genetic character of this molecule takes precedence. On the other hand, there are still no specific approved therapies that reduce its levels and arouse sufficient interest for its management. However, many societies, such as the European Society of Cardiology (SEC) or the Spanish Society of Atherosclerosis (SEA), raise the need to determine Lp(a) and intensive management of cardiovascular risk factors in patients with high Lp(a) levels along with therapies that mitigate the associated ASCVD risk. Likewise, the identification of high levels of Lp(a) offers the opportunity to screen family members, better control of cardiovascular risk and the possibility of developing clinical trials that profile individual and population risk that allow for more personalized actions.
Servei de Salut de les Illes Balears, Palma de Mallorca, España.
Jubilado, Getxo, Bizkaia, España. Electronic address: adal1953@hotmail.com.
[Lp(a): What we know, what we don't know and what we hope for].
Anant Bajaj Retina Institute, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India.
Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute MTC Campus, Bhubaneswar, Odisha, India.
Anant Bajaj Retina Institute, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India srikantkumar.padhy19@gmail.com.
Gyrate atrophy with vitreous haemorrhage: a rare combination.
School of Nursing, University of Connecticut, Storrs, Connecticut, USA Tiffany.Gwartney@uconn.edu.
Developing a personalised approach to assessing and supporting paternal needs in the NICU promotes emotional openness, involvement and autonomy.
Hôpital Novo, site d'Aincourt, Parc de la Bucaille, 95510 Aincourt, France. Electronic address: jean-luc.poindessous@ght-novo.fr.
Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013 Paris, France. Electronic address: marine.bourgninaud@gmail.com.
Department of Surgery, Lillebaelt Hospital, Kolding, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. Electronic address: louise.lerche.pontoppidan2@rsyd.dk.
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital; Aarhus Denmark Microdialysis Research Group (ADMIRE), Aarhus University Hospital, Aarhus, Denmark.
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Vascular Surgery, Lillebaelt Hospital, Kolding.
Department of Surgery, Aarhus University Hospital, Aarhus, Denmark.
Department of Surgery, Aalborg University Hospital, Aalborg, Denmark.
Department of Orthopedic Surgery, Viborg Regional Hospital, Denmark.
Aarhus Denmark Microdialysis Research Group (ADMIRE), Aarhus University Hospital, Aarhus, Denmark.
Aarhus Denmark Microdialysis Research Group (ADMIRE), Aarhus University Hospital, Aarhus, Denmark; Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
Piperacillin tissue concentrations in the gastrointestinal tract-a microdialysis porcine study.
NMC Royal Hospital, Abu Dhabi, United Arab Emirates; The National Research Center, Cairo, Egypt.
College of Technological Innovation at Zayed University, Abu Dhabi, United Arab Emirates.
NMC Royal Hospital, Abu Dhabi, United Arab Emirates; Edinburgh Napier University, Merchiston Campus, 10 Colinton Road, Edinburgh, Scotland, EH10 5DT, UK. Electronic address: asrar.rashid@napier.ac.uk.
NMC Royal Hospital, Abu Dhabi, United Arab Emirates.
Cambridge Medical & Rehabilitation Center Abu Dhabi Branch, United Arab Emirates.
Faculty of Health Sciences, Fenerbahçe University, İstanbul, Turkey.
Mediclinic Alnoor Hospital, Abu Dhabi, United Arab Emirates.
Department of Clinical Biochemistry, SKIMS, Srinagar, J&K, India.
Internal medicine department, Faculty of medicine, Kasr Al Ainy Faculty of Medicine, Cairo university, Al-Manial Cairo, 11956, Egypt.
Medical University of South Carolina, Charleston, SC.
Royal Lancaster Infirmary, Lancaster, United Kingdom. Electronic address: alaaldeen_m@yahho.com.
Centro de investigation en Salud Publica y Epidemiologia Clinica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador.
Universidad Espiritu Santo, Samborondon, Ecuador; Respiralab Research Group, Guayaquil, Ecuador.
Effectiveness of postoperative cephalosporins in reducing urinary tract infections and other parameters following transurethral resection of the prostate: a systematic review and meta-analysis.
Service de néphrologie consultations 3(e) G., CHU Grenoble-Alpes, Boulevard de la Chantourne, 38700 La Tronche, France. Electronic address: nbrion@chu-grenoble.fr.
Institut de formation aux métiers de la santé, Centre hospitalier Alès-Cévennes, 811 avenue du Docteur-Jean-Goubert, 30100 Alès, France. Electronic address: fpastre@ch-ales.fr.
Department of Plastic, Reconstructive and Aesthetics Surgery, Sengkang General Hospital, Singapore, Singapore; Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taipei, Taiwan. Electronic address: allen.wong.wei.jiat@gmail.com.
Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.
Department of Plastic, Reconstructive and Aesthetics Surgery, Sengkang General Hospital, Singapore, Singapore.
Microsurgical treatment of primary lymphedema: A systematic review and meta-analysis.
Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL; Department of Surgery, Uniformed Services University F Edward Hébert School of Medicine, Bethesda, MD.
Department of Surgery, San Antonio Military Medical Center, San Antonio, TX.
Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Department of Surgery, Uniformed Services University F Edward Hébert School of Medicine, Bethesda, MD; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address: jeremy.cannon@pennmedicine.upenn.edu.
Management of traumatic pneumothorax and hemothorax.
Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea. Electronic address: kangsb@snubh.org.
Oncologic impact of technical difficulties during the early experience with laparoscopic surgery for colorectal cancer: long-term follow-up results of a prospective cohort study.
Mayo Clinic Alix School of Medicine, Rochester, MN.
Division of General Surgery, Department of Surgery, Stanford University, Stanford, CA. Electronic address: dhindin@stanford.edu.
Generative AI & machine learning in surgical education.
Surgical Oncology Research Fellow, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Surgical Oncology Clinical Fellow, Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Pathology Research Vice Chair, Department of Pathology, Moffitt Cancer Center, Tampa, Florida.
Chair of Surgery, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Chief of Surgery and Chair of the Department of Sarcoma, Departments of Cutaneous Oncology and Sarcoma, Moffitt Cancer Center, Tampa, Florida.
Chief Academic Officer and Chair of the Department of Oncologic Sciences. Electronic address: jonathan.zager@moffitt.org.
Department of General Surgery, Affiliated Wuhu Traditional Chinese Medicine Hospital of Anhui Traditional Chinese Medicine University, Wuhu City, Anhui Province, 241000, China.. Electronic address: jw254307090@163.com.
Department of General Surgery, Affiliated Wuhu Traditional Chinese Medicine Hospital of Anhui Traditional Chinese Medicine University, Wuhu City, Anhui Province, 241000, China.
Application of self-traction and transection technique in total laparoscopic gastrectomy.
Pôle de formation et de recherche en santé, Université de Caen, 2 rue des Rochambelles, 14032 Caen, France. Electronic address: sonia.guillouet@unicaen.fr.
Department of breast and thyroid surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China.. Electronic address: wuyaqin1996@163.com.
Department of breast and thyroid surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China.; Hunan research institute of geriatrics, Changsha, Hunan 410024, China.
Department of breast and thyroid surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China.. Electronic address: 27528957@qq.com.
Department of breast and thyroid surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China.
Clinical observational study of gasless endoscope-assisted modified radical mastectomy combined with stage I prosthesis reconstruction through anterior axillary line incision.
GKT Medical School, King's College London, London, United Kingdom. Electronic address: abdullatif.aydin@kcl.ac.uk.
Department of Orthopaedic Surgery, King's College Hospital, London, United Kingdom.
MRC Centre for Transplantation, Guy's Hospital, King's College London, London, United Kingdom.
Simulation-based training in orthopedic surgery: A systematic review.
Department of Surgery, University of Albany Medical College, Albany, NY.
Division of Surgical Oncology, Department of Surgery, Duke University Medical Center, Durham, NC.
Division of Surgical Oncology, Department of Surgery, Duke University Medical Center, Durham, NC. Electronic address: allison.martin@duke.edu.
The state of DEI in surgical oncology: Progress, gaps, and future directions.
Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
De La Salle University Medical Centre, Philippines.
Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Surgical Oncology, National University Cancer Institute, Singapore.
Department of Anaesthesia, National University Hospital, Singapore.
Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, National University Hospital, Singapore. Electronic address: daryl_chia@nuhs.edu.sg.
Mediastinoscopic-assisted transhiatal esophagectomy (MATHE) in patients with significant respiratory co-morbidities - case series and review of literature.
Department of Oral and Maxillofacial Surgery, National University of Malaysia, Kuala Lumpur, Malaysia. Electronic address: ramakrsna@ukm.edu.my.
Department of Oral and Maxillofacial Surgery, National University of Malaysia, Kuala Lumpur, Malaysia.
Department of Restorative, Faculty of Dentistry, National University of Malaysia, Kuala Lumpur, Malaysia.
Orthognathic surgical success in the eye of the patient: Are we prepared to handle complications emerging from the changing mental health profiles of our patients.
Department of CT&MRI Room, Qianjiang Central Hospital, Qianjiang, Hubei Province, China.
Department of Radiology, Mianyang Central Hospital, Mianyang, Sichuan Province, China.
Department of Radiology, the Affiliated Hospital of Tibet Minzu University, Xianyang, Shaanxi Province, China. Electronic address: rainfogs@163.com.
Investigation of the impact of magnetic resonance imaging-assisted surgery on immune cell cytokine levels and efficacy in patients with gliomas.
Department of Integrated Traditional Chinese and Western Medicine, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Cancer Hospital, Nanjing 210000, Jiangsu, China.
Department of Orthopedics, Yili Traditional Chinese Medicine Hospital, 835000, Xinjiang, China.
Department of Orthopedics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu, China; Department of Orthopedics, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210000, Jiangsu, China. Electronic address: hwd505@163.com.
The impact of educational level on rehabilitation outcomes after total knee arthroplasty in patients with knee osteoarthritis: A retrospective study.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Recep Tayyip Erdoğan University, Rize, Turkey. Electronic address: zeynep_dt@hotmail.com.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Recep Tayyip Erdoğan University, Rize, Turkey.
Department of Histology Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
School of Vocational Healh Care Services, Department of Medical Services and Techniques Recep Tayyip Erdoğan University, Rize, Turkey.
Private Practice, S Dental Polyclinic Osmaniye, Turkey.
Department of Histology Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Department of Physiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
Evaluation of the effects of low-level laser and steroid therapy, separately or in combination for the treatment of facial nerve injury: An experimental study in rats.
Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi City, 830000, Xinjiang, China.
Department of Critical Care Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi City, 830000, Xinjiang, China.
Cardiovascular Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi City, 830000, Xinjiang, China. Electronic address: 17690945105@163.com.
CABG triumphs over PCI: A meta-analysis reveals superior long-term outcomes for LMCAD.
R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD, 21201. Electronic address: mharfouche@som.umaryland.edu.
Department of Surgery, University of Texas at Austin, Austin, TX, 78701.
R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD, 21201.
For better or for worse: The effect of acute alcohol intoxication on outcomes after blunt trauma.
Department of Nursing, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, 610000, Sichuan, China.
Department of Nursing, Qionglai Hospital of Traditional Chinese Medicine, Qionglai, 611530, Sichuan, China.
Department of Oral and Maxillofacial Surgery, ZhongShan Hospital Fudan University, Shanghai, 200032, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Department of Rehabilitation, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, 610000, Sichuan, China.
Department of Nursing, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, 610000, Sichuan, China. Electronic address: 15326022164@163.com.
Clinical research on staged functional exercise for donor site limb rehabilitation after vascularized fibular flap surgery in oral cancer patients.
Department of Hernia and Hepatobiliary Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Department of Hernia and Hepatobiliary Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China. Electronic address: yezhiyu2023@163.com.
The connection between surgical margins in liver metastases from colorectal cancer and patient prognosis: A mini review.
Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
Mathematics Division, Centre for Foundation Studies in Science, Universiti Malaya, Kuala Lumpur, Malaysia; Center for Data Analytics Consultancy and Services, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address: firdaushariri@um.edu.my.
Orthognathic surgery in syndromic craniosynostosis: Incorporating midface morphometric analysis and dental parameters in surgical planning.
American chaos: standing up for health and medicine.
Marcus Lacerda: aiming to eliminate vivax malaria.
Departamento de Ciências Sociais, Universidade Federal Fluminense, Campos dos Goytacazes, Rio de Janeiro 28010-385, Brazil. Electronic address: cvalpassos@id.uff.br.
Departamento de Ciências Sociais, Universidade Federal Fluminense, Campos dos Goytacazes, Rio de Janeiro 28010-385, Brazil.
Department of Sociology, Criminology, and Anthropology, Colorado State University Pueblo, Pueblo, CO, USA.
Attacks on reproductive rights in Brazil.
Health, rights, and work on the margins.
Department of Biomedical Data Science, Stanford University, Stanford, CA 94304, USA. Electronic address: jamesz@stanford.edu.
Scripps Research Translational Institute, La Jolla, CA, USA.
The rise of agentic AI teammates in medicine.
Bioaerosol Laboratory, Konkuk University, Seoul 05029, South Korea. Electronic address: leebu@konkuk.ac.kr.
More physicians needed for more hope in South Korea.
Department of Emergency Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: lederman@hku.hk.
Department of Emergency Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
Department of Anthropology, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Centre for Biomedical Ethics, National University of Singapore, Singapore.
Unit 731 and history-informed professional identity formation.
Department of Virology, National Institute of Health, Chak Shahzad, 45500 Islamabad, Pakistan. Electronic address: m.umair@nih.org.pk.
Department of Virology, National Institute of Health, Chak Shahzad, 45500 Islamabad, Pakistan.
Comprehensive response to mpox in Pakistan.
Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colo. Electronic address: anne.fuhlbrigge@cuanschutz.edu.
Breathing Institute, Children's Hospital Colorado, Department of Pediatrics, Pediatric Pulmonary and Sleep Medicine Section, University of Colorado School of Medicine and Children's Hospital Colorado, Anschutz Medical Campus, Aurora, Colo.
J Allergy Clin Immunol Pract. 2025-02;13(2):308-309.
Systemic Corticosteroids: The Importance of Limiting Their Use in Asthma.
Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Roanoke Va.
Department of Health Systems & Implementation Science, Virginia Tech Carilion School of Medicine, Roanoke, Va; Section of Allergy & Immunology, Department of Medicine, The Carilion Clinic, Roanoke, Va. Electronic address: nick70@vt.edu.
J Allergy Clin Immunol Pract. 2025-02;13(2):396-397.
Identifying Precise Disparities Among Persons With Inborn Errors of Immunity.
Department of Internal Medicine, Division of Allergy and Immunology, University of Nebraska Medical Center, Omaha, Neb. Electronic address: japoole@unmc.edu.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Mass.
J Allergy Clin Immunol Pract. 2025-02;13(2):295-297.
Climate Change and the Practice of Allergy and Immunology.
Department of Bioinformatics, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China. Electronic address: 2021220107@stu.cqmu.edu.cn.
Department of Bioinformatics, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
Department of Bioinformatics, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China. Electronic address: liuth@cqmu.edu.cn.
J Allergy Clin Immunol Pract. 2025-02;13(2):447.
Exploring the link between asthma onset in pregnancy and adverse perinatal events.
This study addressed the gaps in the disclosure of statin-associated adverse drug reactions (ADRs) in China's official database and the inadequacy of cases reported relative to the population size in public ADR databases.To address these limitations, we conducted a retrospective trial-based analysis using data from Chinese journals to comprehensively assess statin-associated ADRs from 1992 to 2023, focusing on liver (2895 studies, n = 163 810) and muscle (2888 studies, n = 161 714) related outcomes.For large sample size clinical trial analysis (n≥100), our analysis encompassed data from 31 763 participants for muscle-related ADRs (incidence rate: 0.004-0.006, common effect model; 0.002-0.006, random effects model) and 31 281 participants for liver-related ADRs (incidence rate: 0.004-0.006, common effect model; 0.003-0.006, random effects model), covering various statins, including atorvastatin, simvastatin, rosuvastatin, fluvastatin, pitavastatin, pravastatin and lovastatin. Notably, muscle-related ADRs, particularly rhabdomyolysis, were most prevalent with fluvastatin, lovastatin and pravastatin, showing rates of 0.90%, 0.74% and 0.53%, respectively. Pitavastatin and atorvastatin were frequently associated with liver-related ADRs such as abnormal liver function and elevated enzymes, with rates of 5.36% and 1.819%, respectively.This study underscores significant variations in ADR incidence among different statins in the Chinese population, providing critical insights for healthcare professionals and policymakers to enhance patient safety and optimise clinical decisions regarding statin therapy.
© European Association of Hospital Pharmacists 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, Shanghai, China standhavemail@yahoo.com.tw.
School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, Shanghai, China.
PLA Navy Characteristic Medical Center, Shanghai, Shanghai, China.
European journal of hospital pharmacy : science and practice
Evaluation of statin-induced muscle and liver adverse drug reactions in the Chinese population: a retrospective analysis of clinical trial data from 1992 to 2023.
Center for Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; National Clinical Research Center on Obstetrics and Gynecology (OBYGN) Disease, Beijing Branch Center, Beijing, China; Department of Obstetrics and Gynecology, Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang, China.
Department of General Practice, Peking University Third Hospital, Beijing, China.
School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing China.
Center for Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; National Clinical Research Center on Obstetrics and Gynecology (OBYGN) Disease, Beijing Branch Center, Beijing, China. Electronic address: wjgqhn@263.net.
J Allergy Clin Immunol Pract. 2025-02;13(2):448.
Reply to Exploring the link between asthma onset in pregnancy and adverse perinatal events .
Our study aimed to investigate the relationship between the geometric distribution of plaque calcification and the occurrence of postprocedural hypotension following carotid artery stenting (CAS).We retrospectively analyzed data from CAS patients between April 2018 and February 2023. Plaque calcification was evaluated using cross-sectional images obtained from multiplanar reconstructions perpendicular to the longitudinal axis of the internal carotid artery (ICA). The cross-sectional image of the most stenotic ICA was segmented into four quadrants: interior, exterior, ventral, and dorsal. We innovatively defined the geometric classification of plaque calcification based on physiological anatomy as modified calcification location. Postprocedural hypotension was defined as persistent systolic blood pressure at <90 mmHg, requiring intravenous vasopressor infusions that lasted more than 1 hour.A total of 477 patients were included in the final analysis. Among them, 41 (8.6%) patients experienced postprocedural hypotension after CAS. For the modified geometric method, plaque calcification was found significantly more frequently in the hypotension group compared with the non-hypotension group in the dorsal quadrant. Binary logistic regression analysis showed that modified calcification location on the dorsal side (OR 3.520, 95% CI 1.497 to 8.274, p=0.004) were independently associated with postprocedural hypotension after CAS.The presence of plaque calcification on the dorsal side, using the modified geometric method, was found to be associated with a three-fold increased risk of postprocedural hypotension after CAS. These findings may have implications for patient screening, procedure planning, and hospitalization duration expectations.
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
Department of Neurology, The Second Affiliated Hospital of Zhejiang University, School of Medicine; State Key Laboratory of Transvascular lmplantation Devices, Hangzhou, Zhejiang, China.
Department of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Neurology, Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China raymond1202@126.com 1979wwww@163.com.
Geometric distribution of plaque calcification is associated with postprocedural hypotension after carotid artery stenting.
Approximately 20% of ischemic strokes involve the posterior circulation, primarily supplied by the vertebrobasilar system. While much is known about the stroke risk of vertebrobasilar stenotic disease in general, particularly those involving intracranial pathology, extracranial vertebral artery stenosis remains an underinvestigated pathology. In this narrative review, we highlight retrospective, prospective, and randomized trial data on extracranial vertebral artery diseases with a particular focus on the role of endovascular stenting in its management. We also discuss the role of advanced imaging modalities such as quantitative magnetic resonance angiography for stroke risk stratification and patient selection for stenting.
Neurology, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.
Interventional Radiology, Oregon Health & Science University, Portland, Oregon, USA.
Neurosurgery, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Neurosurgery, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA ptkan@utmb.edu.
Endovascular management of extracranial vertebral artery stenosis.
Intracranial dural arteriovenous fistulas (DAVFs) are rare lesions, making it challenging to fully understand and improve their management. Globally, only two major large-scale studies have focused on DAVFs. This report outlines the design of the DREAM-INI (Dural arteriovenous fistula research and management in China) project and provides an overview of the 1101-patient cohort it includes.Patient data were sourced from the DREAM-INI database, a retrospective, single-center observational study conducted from January 2001 to December 2022, encompassing a total of 1101 DAVF patients.The cohort consists of 367 patients diagnosed with Borden type I DAVFs, 172 patients with Borden type II fistulas, and 562 patients with Borden type III fistulas. 565 patients exhibited flow-related symptoms, 176 patients presented with intracranial hemorrhage, and 275 patients had non-hemorrhagic neurological deficits. A large proportion of patients (95.6%, 1053/1101) underwent treatment through endovascular embolization (83.7%, 922/1101), surgery (8.7%, 96/1101), or multimodal therapy (3.2%, 35/1101). The overall immediate angiographic cure rate was 85.2% (897/1053 treated cases), and the rate of treatment-related permanent neurological morbidity was 3.4% (45/1328 total procedures). The median duration from the final treatment to the last follow-up for DAVF was 39 months. The predictive factors for aggressive symptoms, initial angiographic cure, and complications in DAVFs have also been preliminarily explored.With over 1100 patients, DREAM-INI represents a large and relatively well-documented registry of DAVF patient data in China and even globally. This database will enable numerous future studies, further advancing our understanding of this rare disease.
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China.China International Neuroscience Institute (CHINA-INI), 100053, Beijing, China.
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China zhangpengwr@126.com xwzhanghq@163.com yyneurosurgeon@163.com.China International Neuroscience Institute (CHINA-INI), 100053, Beijing, China.
Dural arteriovenous fistula research and management in China (DREAM-INI): initial characterization and patient cohort outcomes.
Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits might be observed in frail patients.The coMOrbilidades Síndrome Coronario Agudo - FRAIL (MOSCA-FRAIL) trial included 167 adults aged ≥70 years with frailty (Clinical Frailty Scale ≥4 points) and NSTEMI, who were randomised to invasive (n=84) or conservative (n=83) strategy during the index hospitalisation. The primary end point of this subanalysis was reinfarction, considering all-cause mortality as a competing event, at a 3-year median follow-up. The time to first reinfarction and all reinfarctions (first and recurrent) were considered. The substudy was not prespecified.The total number of deaths (93, 56%) exceeded that of first reinfarctions (32, 19%). Invasive treatment did not influence the reinfarction risk when accounting for death as a competing risk (subdistribution HR=0.87, 95% CI 0.54 to 1.40, p=0.56). An initially increased mortality risk with invasive management (significant between days 131 and 175) shifted to a lower mortality risk over time. A total of 45 reinfarctions (first and recurrent) were observed. The longitudinal trajectories corroborated that the invasive strategy did not reduce the risk of reinfarction over time (p=0.72). However, mortality followed a biphasic pattern, with higher mortality in the invasive group during the first 6 months and a reduction between 9 months and 3 years (p=0.05 for the entire time-dependent trajectory). The win ratio for the invasive strategy versus the conservative strategy was 1.08 (95% CI 0.72 to 1.63, p=0.70).In older adults with frailty and NSTEMI, routine invasive management did not reduce the reinfarction risk at a 3-year follow-up. The high all-cause mortality associated with frailty may limit the impact of invasive management. Due to the limited sample size and risk for type II error, these findings should be considered hypothesis-generating.NCT03208153.
Cardiology, Hospital Clínic Universitari, INCLIVA, Universitat de València, CIBERCV, València, Spain sanchis_juafor@gva.es.
Centro Nacional de InvestigacionesCardiovasculares (CNIC), Madrid, Spain.Cardiology, Hospital Universitario 12 de Octubre, and Universidad Complutense de Madrid, Madrid, Spain.
Cardiology, Central Defense Hospital, Madrid, Spain.
Cardiology, Hospital Universitario Gregorio Marañón, CIBERCV, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Europea, Universidad Complutense, Madrid, Spain.
Cardiology, Hospital Universitario La Princesa, Universidad Autónoma de Madrid, CIBERCV, Madrid, Spain.
Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Cardiology, Hospital Universitario Virgen de la Arrixaca, CIBERCV, Murcia, Spain.
Cardiology, Hospital Universitario del Sudeste, Arganda del Rey, Madrid, Spain.
Cardiology, Hospital Universitario Ramon y Cajal, CIBERCV, Madrid, Spain.
Cardiology, Hospital Universitari Germans Trias i Pujol, CIBERCV, Badalona, Spain.
Cardiology, Hospital de la Santa Creu i Sant Pau, Universitat de Barcelona, CIBERCV, Barcelona, Spain.
Cardiology, Hospital Clínic Universitari, INCLIVA, Universitat de València, CIBERCV, València, Spain.
Translational and Clinical Research Institute Faculty of Medical Sciences, Newcastle University, and the Cardiothoracic Centre, Freeman Hospital Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Coronary Care Unit, Cardiology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Effects of routine invasive management on reinfarction risk in older adults with frailty and non-ST-segment elevation myocardial infarction: a subanalysis of a randomised clinical trial.
Intracranial atherosclerotic disease (ICAD) is a leading cause of stroke, often refractory to aggressive medical therapy. Recent advancements in drug-eluting stents (DES) show promise for improved efficacy in intracranial applications relative to traditional ICAD treatments.We retrospectively collected all consecutive deployments of the Onyx Frontier [Medtronic, Santa Rosa, CA] stent in the setting of ICAD between August 2022 and August 2024 at six high-volume neuro-interventional centers across the US. Patients were included if their indication for stenting (eg, acute/recurrent stroke) was secondary to ICAD. Primary outcome was periprocedural stroke (<72 hours) and secondary outcomes included degree of pre- and post-stent vessel stenosis and National Institutes of Health Stroke Scale (NIHSS) scores at most recent follow-up. Secondary outcomes were assessed via paired t-tests.Among 55 patients that met our inclusion criteria, the mean age was 62, mean presentation NIHSS was 10, and 40% were female. A total of 62 devices were used. Most common occlusion locations included the middle cerebral and internal carotid arteries. The periprocedural stroke rate was 10.9%, with a mortality rate of 1.8%. Mean vessel stenosis significantly decreased from 84.90% pre-stent to 2.00% post-stent (P<0.05). Mean NIHSS score improved from 10.37 preoperatively to 3.23 at follow-up (p<0.05). Procedural failure did not occur, however complications occurred in 16.4% of cases.Our findings suggest that stenting in this setting results in a lower periprocedural stroke rate than appreciated in historical trials such as SAMMPRIS and VISSIT. However, recent CASSISS and BASIS trials demonstrate far reduced periprocedural stroke rates in the context of submaximal angioplasty for ICAD. This, in conjunction with complication rate, suggest that the Onyx Frontier, while promising, may not offer a definitive solution to ICAD.
Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Department of Neurosurgery, University of Utah Health, Salt Lake City, Utah, USA.
Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA.
Neurology, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Department of Neurosurgery, Montefiore Medical Center, Bronx, New York, USA.
Department of Neurological Surgery and Montefiore-Einstein Cerebrovascular Research Lab, Albert Einstein College of Medicine, Bronx, Montefiore Medical Center, New York, New York, USA.
Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA visishs@upenn.edu.
Onyx frontier DES in the setting of intracranial atherosclerotic disease: multicenter retrospective insights from early clinical experience.
Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center Department of Anesthesiology and Perioperative Medicine, Houston, Texas, USA.
Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center Department of Anesthesiology and Perioperative Medicine, Houston, Texas, USA jcata@mdanderson.org.Anesthesiology and Surgical Oncology Research Group, Houston, Texas, USA.
Understanding regional anesthesia's impact on non-muscle invasive bladder cancer oncological outcomes.
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA louisian@usc.edu.
Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
University of Southern California, Los Angeles, California, USA.
Expanding synthetic nicotine commercial market: Aroma King's 'NoNic' pouches and e-cigarettes.
Ocular ischemic syndrome (OIS) and subsequent neovascular glaucoma (NVG) lead to irreversible visual impairment. This study aimed to investigate the association of carotid artery revascularization and the collateral circulation types via the circle of Willis (CoW) with NVG and visual prognosis in patients with OIS.This retrospective cohort study included 22 patients with OIS, with a median follow-up of 12 months. The collateral circulation patterns via the CoW were classified into five types. The association of the carotid artery revascularization, collateral circulation types via the CoW, and morphological characteristics of the CoW with the presence of NVG and visual outcomes was assessed.The median time interval from baseline to visual decline during follow-ups in patients with carotid artery revascularization was longer than that in patients without carotid artery revascularization (13 months vs 9.5 months, P=0.041). Lacking collateral inflow via the CoW to the hemisphere ipsilateral to OIS was associated with NVG (odds ratio (OR), 11.000; P=0.022). The diameters of the C6 and C7 segments of the internal carotid artery, the A1 segment of the anterior cerebral artery, and the ophthalmic artery in OIS eyes were smaller than those in the contralateral eyes.Early carotid artery revascularization should be considered in patients with OIS, with or without NVG, as it may contribute to an improved visual prognosis. Patients without collateral inflow via the CoW to the hemisphere ipsilateral to OIS may have a higher risk of NVG.
Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.Institute of Ophthalmology, Capital Medical University, Beijing, China.
Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.
Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China wangjialin@bjmu.edu.cn.Institute of Ophthalmology, Capital Medical University, Beijing, China.
Carotid revascularization and circle of Willis in ocular ischemic syndrome: association with neovascular glaucoma and visual prognosis.
Department of Epidemiology, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, China.Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Department of Epidemiology, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Director Office, Zhangjiagang County Center for Disease Control and Prevention, Zhangjiagang, China.
Director Office, Danyang County Center for Disease Control and Prevention, Danyang, China.
Major Project Executive Office, Taixing County Center for Disease Control and Prevention, Taixing, China.
Department of Epidemiology, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, China.Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.
Cohort Profile: The Chronic Hepatitis B Infection and Liver Disease (HEPCARE) study in Jiangsu, China.
The proximity of transverse sinus stenosis (TSS) to inner ear structures and the temporal bone makes it a substantial cause of pulsatile tinnitus (PT). Treatment typically involves venous sinus stenting. This study investigates the hemodynamic stressors in TSS patients with PT along the pulse-transmitting temporal bone area and evaluates its treatment effects.Four patients with idiopathic intracranial hypertension, PT, and TSS, and four control patients were imaged using MR venography (MRV) and flat panel CT (FP-CT). Patient-specific blood flow simulations were conducted using boundary conditions based on quantitative MR angiography before and after VSS. Catheter-based trans-stenotic pressure gradient measurements were used to validate the simulation results.The prediction of pressure gradients was close to catheter-based measurements using FP-CT-based segmentations (absolute deviation of 0.35 mm Hg) and is superior to MRV-based reconstructions (absolute deviation of 6.9 mm Hg). In TSS patients, the sinus temporal bone contact areas revealed notably higher time-averaged wall shear stress by 47±22% and velocity values by 41±18% compared with the sinus brain side. The relative residence time decreased by 57±58%. After stenting, the hemodynamic parameters dropped at the temporal side and throughout the sigmoid sinus. Almost all control patient hemodynamics remained lower than post-interventional results.Our simulations based on patient-specific flows highly predicts pressure gradients across the stenosis. Flow conditions in TSS reveal flow jet formation and high shear rates at the temporal bone, potentially causing sound transmission. The treatment reduces these stressors, demonstrating its targeted therapeutic effect.
Research Campus STIMULATE, Otto von Guericke University Magdeburg, Magdeburg, Germany janneck.stahl@ovgu.de.Department of Medical Engineering, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Neurosurgery, University of Illinois Chicago, Chicago, Illinois, USA.
Department of Neurosurgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Research Campus STIMULATE, Otto von Guericke University Magdeburg, Magdeburg, Germany.Department of Fluid Dynamics and Technical Flows, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Research Campus STIMULATE, Otto von Guericke University Magdeburg, Magdeburg, Germany.Institute for Medical Informatics and Statistics, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany.
Research Campus STIMULATE, Otto von Guericke University Magdeburg, Magdeburg, Germany.Department of Medical Engineering, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Flow-based simulation in transverse sinus stenosis pre- and post-stenting: pressure prediction accuracy, hemodynamic complexity, and relationship to pulsatile tinnitus.
Finland's New Children's Hospital (NCH) opened in 2018 after a high-profile charity campaign. Through an analysis of the campaign, we illustrate how debates about children's hospitals and charities are simultaneously shaped by universal debates over the ownership and funding of healthcare services, and by the particularities of historical context and local institutional arrangements. Such debates also draw from and contribute to shaping cultural repertoires, particularly shared beliefs and values concerning children, the state and charity. In Finland, the NCH marked a break from an established model of publicly funded hospitals, and a return to the pre-welfare state era when charities played a role in healthcare. The campaign thus generated substantial public debate, in which we identify three core claims: (1) Hospitals must be built with public funding and oversight. (2) Children are suffering because politicians have failed, and a new model is needed. (3) The NCH further strengthens Finland's excellence in paediatric healthcare and promotes health technology exports. Over the course of the campaign, critique faded away, and the second and third lines of argument came to dominate public debate. Through a reflection on the historically changing relations between state, charity and children that shaped what we conceptualise as the NCH assemblage, we show how clichéd cultural tropes naturalised the political shift toward a post-welfare state that is embedded in the NCH campaign. As citizens without voter rights, children are exceptionally easy for politicians to sidestep when allocating funds. Yet, as what Sara Ahmed describes as 'objects of feeling', children are also exceptionally potent targets for charity, who, in the NCH case, came to serve as tools for the neoliberal disassembling and reassembling of healthcare services in Finland.
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.
Unit of Social Research, Tampere University, Tampere, Finland henni.alava@tuni.fi.
Unit of Social Research, Tampere University, Tampere, Finland.
Finland's New Children's Hospital and resurgent charity in a Nordic post-welfare state.
The purpose of this study is to analyze professionals' representations of parents with mental and/or physical health conditions.We interviewed 51 health professionals and social workers. Using an inductive approach and NVivo software, we proceeded to a qualitative analysis. To comprehensively examine the content of professionals' responses, each coding unit was assessed according to its theme (representation of the family, representation of the condition, actions on representations) and valence (negative, cautious, positive or neutral tone).Three major themes emerged from the interviews: 1 - Family representations: The child is vulnerable and negatively impacted by parents with mental and/or physical health conditions. This impact is embodied mostly by the mother, the father being seen as a subsidiary parental function or a potential intermediary. The extended family is invested as a protective factor. 2 - Condition representations: Physical impairment is more positively viewed than mental health conditions, psychosis being particularly negative; physical impairments are seen as more compatible with qualitative parenthood. 3 - Actions on representations: Becoming aware of their representations and reflecting on them allow professionals to think of the unique character of each situation and to put their representations into perspective; time and exposure to parents with health conditions leads them to revise their most negative representations.While the results are broadly in line with the literature, this study investigates in detail the previously unexplored point of view of professionals. Revealing their representations may contribute to improving practices and care provided to families with mental and/or physical health conditions.
Copyright © 2025 L'Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.
Laboratory of Psychopathology and Health Processes, Institute of Psychology, University Paris Cité, 71, avenue Édouard-Vaillant, 92100 Boulogne-Billancourt, France.
Laboratory of Psychopathology and Health Processes, Institute of Psychology, University Paris Cité, 71, avenue Édouard-Vaillant, 92100 Boulogne-Billancourt, France; Unité petite enfance et parentalité Vivaldi, CHU Pitié-Salpêtrière, Paris, France. Electronic address: jaqueline.wendland@u-paris.fr.
Health professional's representations of parents with illnesses or disabilities.
Prison psychosis is a historical concept that is still used in clinical practice, but little explored in research. In this short paper, we propose to revisit this concept by studying first-episode psychosis (FEP) in the prison population. We analyzed a series of incarcerated people who were hospitalized for a FEP from November 2020 to May 2021 in a French facility. We dated the onset of the first psychotic symptoms (PSs) in relation to the date of incarceration and of hospitalization and we calculated the duration of untreated psychosis (DUP). While the characteristics of our sample were consistent with what we know about people diagnosed with psychosis in correctional settings (young men with positive symptoms and psychiatric comorbidities), we found great heterogeneity in the DUP and in the chronological sequence between incarceration and the onset of PSs. This preliminary but original work shows the diversity of first diagnosis of psychosis in prison, reflecting the multiplicity and complexity of interactions between psychosis and incarceration.
Pôle de psychiatrie et de conduites addictives en milieu pénitentiaire, centre hospitalier Gérard-Marchant, 31057 Toulouse, France; Univ. Lille, Inserm, U1172 - Lille Neuroscience & Cognition, 59000 Lille, France. Electronic address: eckmarion@yahoo.fr.
Hôpital Lucien-Bonnafé, EPSM de l'agglomération lilloise, 59100 Roubaix, France.
Department of Psychiatry, CHU Lille, 59000 Lille, France.
Univ. Lille, Inserm, U1172 - Lille Neuroscience & Cognition, 59000 Lille, France; Department of Psychiatry, CHU Lille, 59000 Lille, France.
First-episode psychosis among people who are incarcerated: What is hidden behind the prison psychosis concept?
Cannabis is the most widely used drug in the world, and the therapies proposed to help withdrawal are moderately effective. The MACBETH project is a pilot study in France. It evaluates the effectiveness of the mindfulness-based relapse prevention (MBRP) protocol for active cannabis users.It comprises of two groups, an MBRP group and a Treatment As Usual (TAU) group, each with twenty participants. The primary endpoint reflects the frequency of cannabis use, and some secondary endpoints were evaluated (signs of withdrawal, adherence to treatment, and changes in consumption).We found no significant difference between the two groups on the primary and secondary endpoints. We found one significant difference in the MBRP group by further analysis for treatment adherence via an indirect criterion, the attendance at all sessions (P-value=0.01). The number of units consumed from week 1 to week 8 significantly differed in the MBRP group (P-value<0.05) but not in the TAU group. The average number of units consumed from week 8 to 12 increased by 1.5 in the MBRP group compared with 3.4 in the TAU group. The MBRP protocol appears to be at least as effective as the TAU protocol on the assessed criteria, and the results seem to be more durable, although not significant (P-value=0.2).The MBRP protocol shows interesting results compared to TAU in this major public health problem. Further studies could deepen this field of research, especially by following samples over the long-term and measuring cravings. The MBRP protocol is proving to be an effective and serious alternative psychotherapy to drug therapies in the world of addiction.
Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, 1, rue Dr-Archambault, 54400 Laxou, France. Electronic address: pelerin.jan.marc@gmail.com.
Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, 1, rue Dr-Archambault, 54400 Laxou, France.
Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, 1, rue Dr-Archambault, 54400 Laxou, France; Maison des Addictions, CHRU de Nancy, 54000 Nancy, France; Inserm U1114, Fédération de Médecine Translationnelle de Strasbourg, Département de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France.
Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, 1, rue Dr-Archambault, 54400 Laxou, France; Maison des Addictions, CHRU de Nancy, 54000 Nancy, France; Centre d'Investigation Clinique (CIC), Inserm 9501, CHU de Nancy, 54000 Nancy, France.
CHRU de Nancy, Université de Lorraine, 54000 Nancy, France.
Institut de Cancérologie de Lorraine, 54519 Vandœuvre-lès-Nancy, France.
Mindfulness-based relapse prevention for cannabis regular users: Finally outcomes of a randomized clinical trial.
Juvenile idiopathic arthritis (JIA) is accompanied by growth retardation especially in severe cases. While the use of biologics has shown efficacy in restoring growth impairment, data from Asia are limited. We aim to investigate the growth of JIA patients and identify those who can benefit from the use of biologics in Taiwan.JIA patients who received regular follow-up and treatment at a tertiary medical center in Taiwan between January 2011 and June 2023 were retrospectively reviewed. General demographics and growth parameters, including body height, body weight, and body mass index (BMI), were collected at the time of biologics initiation, then at 6 and 12 months into treatment and they were transformed into z-scores for further analysis.A total of 104 JIA patients, including 52 biologics-free controls, were enrolled. Enthesitis-related arthritis (ERA) accounted for 51% all cases. The initial z-scores for body height, body weight and BMI were -0.33, -0.35, -0.45, respectively. A significantly higher proportion of biologics-treated patients achieved catch-up growth, defined as a continuous increase in height z-scores 1 year following biologics treatment, compared to the biologics-free controls (38% vs. 12%; p = 0.002) 12 months into treatment. In subgroup analysis, JIA patients with lower initial z-scores for height (p = 0.021), a shorter period between symptom onset and diagnosis (p = 0.026), younger ages at the time of biologics initiation (p < 0.001) and higher accumulative dose of steroid before biologics (p = 0.048) are more likely to achieve catch-up growth. Combining the age at the time of biologics initiation and patients' initial z-score for height may be sufficient to predict catch-up growth following treatment with biologics (AUC = 0.804; p < 0.0001).Growth retardation appears limited among JIA patients in Taiwan. Initiation of biologics at a younger age may improve linear growth, especially for patients initially shorter for their age.
Copyright © 2025 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved.
College of Medicine, Chang Gung University, Taoyuan city, Taiwan.
Division of Pediatric Endocrinology and Genetics, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan city, Taiwan.
Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan city, Taiwan.
Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan city, Taiwan; Institute of Environmental and Occupational Health Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
College of Medicine, Chang Gung University, Taoyuan city, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan city, Taiwan; Department of Pediatrics, New Taipei Municipal TuCheng Hospital, New Taipei city, Taiwan.
College of Medicine, Chang Gung University, Taoyuan city, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan city, Taiwan. Electronic address: joywucgu@hotmail.com.
Biologics promote catch-up growth in young Juvenile idiopathic arthritis patients with lower body height.
Department of Basic Sciences, Faculty of Dentistry, Biomedical Stomatology Research Group, Universidad de Antioquia UdeA, Medellín, Colombia. Electronic address: martin.ardila@udea.edu.co.
Department of Periodontics, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamil Nadu, India.
International journal of oral and maxillofacial surgery
Int J Oral Maxillofac Surg. 2025-02-07;():.
Comment on: Deep convolutional neural network for automatic segmentation and classification of jaw tumors in contrast-enhanced computed tomography images .
Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna Austria; Department of Urology Jikei University School of Medicine Tokyo Japan.
Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna Austria; Collegium Medicum WSB University Dąbrowa Górnicza Poland.
Department of Urology Jikei University School of Medicine Tokyo Japan.
Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna Austria; Department of Urology Semmelweis University Budapest Hungary; Department of Urology, UT Southwestern Medical Center Dallas TX USA; Department of Urology, Weill Cornell Medical College New York NY USA; Department of Urology, Second Faculty of Medicine, Charles University Prague Czechia; Division of Urology, Department of Special Surgery, University of Jordan Amman Jordan; Karl Landsteiner Institute of Urology and Andrology Vienna Austria; Research Center for Evidence Medicine, Urology Department Tabriz University of Medical Sciences Tabriz Iran. Electronic address: shahrokh.shariat@meduniwien.ac.at.
Reply to: Francesco Montorsi, Francesco Montorsi, Giuseppe Rosiello, Marco Moschini, Andrea Salonia, and Alberto Briganti's letter to the Editor re: Akihiro Matsukawa, Takafumi Yanagisawa, Marcin Miszczyk, et al. Trimodality Therapy Versus Radical Cystectomy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Matched Cohort Studies. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2024.11.003.
Intraoral scanners (IOSs) and artificial intelligence (AI) based programs can be used to locate the maximum intercuspal position (MIP). However, the influence of scan extension on the accuracy of the MIP located by using these technologies is uncertain.The purpose of this in vitro study was to analyze the effect of scan extension on the accuracy of the MIP located by using 3 IOSs and an AI-based program.Stone casts mounted in an articulator in MIP were digitized (T710). Two groups were created: complete- (CA group) and half arch (HA group) scan. In the CA-group, complete arch scans of the reference casts were captured with each IOS tested. The nonarticulated scans were duplicated 20 times. In the HA-groups, the right half arch scans of the reference casts were captured with each IOS tested. Six subgroups were generated: 3 IOS (Primescan-IOS, i700-IOS, and Aoralscan3-IOS) and 3 AI (Primescan-AI, i700-AI, and Aoralscan3-AI) subgroups. In the CA-Primescan-IOS subgroup, 10 duplicated scans were articulated in MIP by recording a bilateral occlusal record. In the CA-Primescan-AI subgroup, 10 duplicated scans were articulated in MIP by using an AI-based program (Bitefinder). In the CA-i700-IOS, CA-Aoralscan3-IOS, CA-i700-AI, and CA-Aoralscan3-AI subgroups, the same procedures as in the CA-Primescan-IOS and CA-Primescan-AI subgroups were completed, respectively. In the HA-Primescan-IOS subgroup, 10 duplicated scans were articulated in MIP by capturing a right occlusal record. In the HA-Primescan-AI subgroup, 10 duplicated scans were articulated in MIP by using the AI-based program. In the HA-i700-IOS, HA-Aoralscan3-IOS, HA-i700-AI, and HA-Aoralscan3-AI subgroups, the same procedures as in the HA-Primescan-IOS subgroups were completed, respectively. A program (Geomagic) was used to calculate 36 interlandmark measurements on the virtual articulated casts (control) and each specimen. Three-way ANOVA and Tukey tests were used to analyze trueness (α=.05). The Levene and pairwise multiple comparison tests were used to analyze precision (α=.05).MIP trueness discrepancies were found between the IOS (P<.001), groups (P<.001), and subgroups (P<.001), with a significant interaction IOS×subgroup (P<.001), group×subgroup (P<.001), and IOS×group×subgroup (P<.001). The Primescan and i700 (P=.014) and the Primescan and Aoralscan3 (P<.001) were different from each other. The CA and HA groups (P<.001) were different from each other. The IOS and AI subgroups (P<.001) were different from each other. The Levene test showed significant precision discrepancies between the groups (P<.001) and subgroups (P<.001). The HA scans demonstrated significantly worse precision than the CA scans (P<.001). Additionally, the AI-based program obtained significantly worse precision than the IOS programs tested (P<.001).Scan extension and program impacted the trueness and precision of the MIP. CA groups demonstrated better MIP trueness and worse precision than the HA groups. Primescan obtained better MIP trueness than the i700 and Aoralscan3 systems. The IOSs revealed better MIP trueness and precision than the AI-based program tested.
Copyright © 2025 Editorial Council for The Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.
Affiliate Assistant Professor, Graduate Prosthodontics, Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, Wash; Faculty and Director of Research and Digital Dentistry, Kois Center, Seattle, Wash; and Adjunct Professor, Department of Prosthodontics, School of Dental Medicine, Tufts University, Boston, Mass. Electronic address: marta.revilla.leon@gmail.com.
Associate Professor, Department of Conservative Dentistry and Prosthodontics, School of Dentistry, Complutense University of Madrid, Madrid, Spain.
Associate Professor, Clinical Research and Biostatistics, Eastman Institute of Oral Health, University of Rochester Medical Center, Rochester, NY.
Founder and Director, Kois Center, Seattle, Wash; Affiliate Professor, Graduate in Prosthodontics, Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, Wash; and Private Practice, Seattle, Wash.
Associate Professor, Department of Dental Medicine, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain.
Influence of scan extension on the accuracy of maximum intercuspal position recorded by using intraoral scanners or an artificial intelligence-based program.
Predominantly cystic craniopharyngiomas are benign but challenging intracranial tumors. Due to their proximity to critical neurovascular structures, they pose significant risks in terms of management and potential postoperative complications. This review aims to provide an overview of the current management strategies, assess their outcomes, and discuss limitations inherent to these approaches. We highlight the role of surgery, radiotherapy, and emerging therapeutic modalities, emphasizing the need for individualized treatment plans tailored to the tumor characteristics and patient-specific factors.
Department of Skull Base and Pituitary Surgery, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France; Department of Spine And Robotic Surgery, Humanitas San Pio X Hospital, Milan, Italy. Electronic address: Dr.fcalvanese@gmail.com.
Department of Skull Base and Pituitary Surgery, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France; Neurosurgical Unit, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland. Electronic address: gianpaolo.jannelli@libero.it.
Department of Endocrinology, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon and Center for Rare Pituitary Diseases (HYPO), Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France. Electronic address: Camille.sergeant@chu-lyon.fr.
Department of Skull Base and Pituitary Surgery, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France. Electronic address: romain.manet@neurochirurgie.fr.
Departement of Radiotherapy, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon and Center for Rare Pituitary Diseases (HYPO), Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France. Electronic address: loic.feuvret@chu-lyon.fr.
Department of Neuro-oncology, Hospices Civils de Lyon, Hôpital Pierre Wertheimer, Lyon, France. Electronic address: francois.ducray@chu-lyon.fr.
Department of Endocrinology, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon and Center for Rare Pituitary Diseases (HYPO), Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France. Electronic address: gerald.raverot@chu-lyon.fr.
Department of Skull Base and Pituitary Surgery, Pituitary Tumors Centers of Excellence (PTCOE) of Lyon, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France. Electronic address: emmanuel.jouanneau@chu-lyon.fr.
Best practice & research. Clinical endocrinology & metabolism
Best Pract Res Clin Endocrinol Metab. 2025-02-05;():101981.
Predominantly cystic craniopharyngiomas: Current management approaches, outcomes and limitations.
Real-world data exploring the perioperative outcomes of different surgical treatments for benign prostatic hyperplasia (BPH) are lacking. We aimed to assess the trends of BPH surgeries and compare their perioperative outcomes.We used the GeRmAn Nationwide inpatient Data (GRAND), provided by the Research Data Center of the Federal Bureau of Statistics (2005-2022), and performed multiple patient-level analyses.Our study included 1 355 845 surgical treatments for BPH. Of these, 1 084 650 (79.9%) were transurethral resection of the prostate (TURP), 90 735 (6.9%) simple prostatectomy, 64 325 (4.7%) holmium laser enucleation of the prostate (HoLEP), 58 406 (4.3%) laser vaporization, 25 747 (1.9%) electrovaporization, 15 241 (1.1%) thulium laser enucleation of the prostate (ThuLEP), 7873 (0.58%) prostate incision, 3298 (0.24%) water ablation, 2724 (0.2%) water vapor thermal therapy, 1235 (0.09%) prostate stent, 1100 (0.08%) transurethral needle ablation of the prostate, and 511 (0.03%) prostatic urethral lift. The use of HoLEP, ThuLEP, water ablation, and water vapor thermal therapy has increased exponentially in the last years. After adjusting for the major risk factors in the multivariate regression analysis, simple prostatectomy was associated with the worst outcomes compared with TURP, followed by electrovaporization. On the contrary, HoLEP and ThuLEP were associated with favorable outcomes, in terms of sepsis, ureteral stent placement, transfusion, admission to the intensive care unit, hospital stay, and mortality, compared with TURP. Similarly, minimally invasive surgical therapies were associated with high safety compared with TURP. Nevertheless, our findings are based on retrospective billing data and are prone to a selection bias.The trends and perioperative outcomes of BPH surgery should be taken into consideration to improve clinical decision-making and patient outcomes.
Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
Department of Urology, LMU University Hospital of Munich, Munich, Germany. Electronic address: julian.marcon@med.uni-muenchen.de.
Department of Urology, LMU University Hospital of Munich, Munich, Germany.
Trends and Perioperative Outcomes of Surgical Treatments for Benign Prostatic Hyperplasia in Germany: Results from the GRAND Study.
Department of Urology Affiliated Hospital of Guizhou Medical University Guiyang China.
Department of Urology Affiliated Hospital of Guizhou Medical University Guiyang China. Electronic address: sfgmc@sina.com.
Department of Urology Affiliated Hospital of Guizhou Medical University Guiyang China. Electronic address: litaolitao163361@163.com.
Re: Noel W. Clarke, Andrew J. Armstrong, Mototsugu Oya, et al. Efficacy and Safety of Olaparib Plus Abiraterone Versus Placebo Plus Abiraterone in the First-line Treatment of Patients with Asymptomatic/Mildly Symptomatic and Symptomatic Metastatic Castration-resistant Prostate Cancer: Analyses from the Phase 3 PROpel Trial. Eur Urol Oncol. In press. https://doi.org/10.1016/j.euo.2024.09.013.
Current data on bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC) do not differentiate outcomes by clinical stage. The purpose of this study is to investigate the role of tumor stage in oncologic outcomes in BCG-unresponsive NMIBC undergoing bladder-sparing therapies.Demographic and outcome data for patients with BCG-unresponsive NMIBC were reviewed at ten institutions. The Kaplan-Meier method was used to determine survival differences between the T1 ± carcinoma in situ (CIS), Ta alone, and CIS ± Ta groups. Exploratory analyses were conducted as follows: (1) T1 alone versus Ta alone versus CIS ± T1/Ta and (2) T1/Ta alone versus CIS ± T1/Ta.Among 401 patients, 137 (34%) were T1 ± CIS, 104 (26%) Ta alone, and 160 (40%) CIS ± Ta. Disease progression (p < 0.001), metastasis (p < 0.001), and bladder cancer mortality (p = 0.009) were increased in the T1 ± CIS group versus the Ta alone and CIS ± Ta groups. Cystectomy occurred most often in the CIS ± Ta and T1 groups (p = 0.002). Similar increases were noted in progression (p < 0.001), metastasis (p < 0.001), and bladder cancer mortality (p = 0.004) in T1 alone patients versus the Ta alone and CIS ± T1/Ta groups. There were no differences in outcomes between the T1 alone and T1 + CIS groups. No significant differences in metastasis, bladder cancer mortality, or all-cause mortality were noted when comparing papillary disease only with any CIS. The primary limitation of this study is likely a selection bias due to the retrospective nature of the cohort.Presence of T1 disease is generally associated with worse oncologic outcomes compared with Ta or CIS. T1 and Ta should not be grouped together during comparison with CIS. Radical cystectomy appears largely driven by the presence of CIS.
Copyright © 2025 European Association of Urology. Published by Elsevier B.V. All rights reserved.
University of Texas Southwestern Medical Center Dallas TX USA.
UT MD Anderson Cancer Center Houston TX USA.
Brigham and Women's Hospital Boston MA USA.
University of British Columbia Vancouver BC Canada.
Baylor College of Medicine Houston TX USA.
CHU-Institut Universitaire du Cancer-Oncopôle Toulouse France.
New York University Langone Health New York NY USA.
University of Texas Southwestern Medical Center Dallas TX USA. Electronic address: yair.lotan@utsouthwestern.edu.
Impact of Tumor Stage on Oncologic Outcomes of High-grade Bacillus Calmette-Guérin Unresponsive Non-muscle-invasive Bladder Cancer Undergoing Bladder-sparing Therapies.
Cryptogenic liver abscesses (CLA) caused by hypervirulent Klebsiella pneumoniae (hvKP) strains are emerging in Western countries. The aim of the study was to describe the clinical characteristics of patients from Argentina with hvKP-related CLA as well as the molecular analysis of isolated strains. A retrospective chart review of 15 patients hospitalized in 8 hospitals of Argentina between October 2015 and November 2018 was performed. PCR assays for genes associated with capsular and multilocus sequence typing (MLST) determination and virulence factors were conducted in 8 hvKP isolates from these patients. We found that the mean age of patients was 60 years, 73% of them were men and 40% suffered from diabetes. Bacteremia was detected in 60% of them and 73% had ≥1 metastatic foci of infection. There were no in-hospital deaths, but two patients with endophthalmitis required eye enucleation. Of the 8 studied isolates, 4 belonged to K1 and 4 to K2 serotypes, with the rpmA and iroB genes being present in all of them, and isolates 7 and 5 also harboring the iucA and the rmpA2 genes, respectively. MSLT analysis showed that most of the K1 serotypes belonged to ST23 while a diverse MLST pattern was observed among the K2 strains. In addition, the four hvKP strains associated with metastatic complications and belonging to three distinct sequence types, exhibited the rpmA, iroB and iuc virulence genes. We were able to demonstrate important morbidity associated with this syndrome, a significant diversity in the hvKP clones causing CLA in Argentina, and the potential utility of the rpmA and iroB genes as predictors of virulence.
Copyright © 2024 The Author(s). Publicado por Elsevier España, S.L.U. All rights reserved.
Instituto IDICER (CONICET) Rosario - Facultad Ciencias Médicas - Universidad Nacional de Rosario, Suipacha 590, Rosario, Santa Fe, Argentina; Sanatorio Británico, Paraguay 40, Rosario, Santa Fe, Argentina.
Sanatorio Británico, Paraguay 40, Rosario, Santa Fe, Argentina.
Hospital Santojanni, Pilar 950, Buenos Aires, Argentina.
Hospital Italiano, Juan Domingo Perón 4190, Ciudad Autónoma Buenos Aires, Buenos Aires, Argentina.
Hospital Argerich, Pi y Margall 750, Ciudad Autónoma Buenos Aires, Buenos Aires, Argentina.
Hospital Italiano de Mendoza, Av. De Acceso Este 1070, M5519 San José, Mendoza, Argentina.
Hospital Tornú, Av. Combatientes de Malvinas 3002, Ciudad Autónoma Buenos Aires, Buenos Aires, Argentina.
Clínica Sagrado Corazón, Bartolomé Mitre 1955, Ciudad Autónoma Buenos Aires, Buenos Aires, Argentina.
Instituto Médico Platense, Av. 51 315, La Plata, Buenos Aires, Argentina.
Facultad de Ciencias Bioquímicas y Farmacéuticas - Universidad Nacional de Rosario, Suipacha 531, Rosario, Santa Fe, Argentina.
Sanatorio Británico, Paraguay 40, Rosario, Santa Fe, Argentina; Facultad de Ciencias Bioquímicas y Farmacéuticas - Universidad Nacional de Rosario, Suipacha 531, Rosario, Santa Fe, Argentina. Electronic address: mariangelrinaudo@gmail.com.
Diversity of hypervirulent Klebsiella pneumoniae clones causing cryptogenic liver abscesses and metastatic complications in Argentina.
This study aimed to evaluate the efficacy of injection laryngoplasty (IL) in improving voice quality in patients with unilateral vocal fold paralysis (UVFP), as measured by acoustic parameters.A cohort of 177 patients with UVFP underwent preIL and postIL assessment using maximum phonation time (MPT), Acoustic Voice Quality Index (AVQI), and Acoustic Breathiness Index (ABI), in conjunction with auditory-perceptual (A-P) ratings and the Voice Handicap Index-10 (VHI-10).Significant improvements were observed across all acoustic and perceptual measures following IL. MPT, AVQI, and ABI, as analyzed using Praat, provided comprehensive quantification of voice recovery. All three measures showed high diagnostic accuracy, with area under the curve values of ≥ 0.73. Receiver-operating characteristic analysis identified effective cutoff values for MPT, AVQI, and ABI, confirming their predictive value for voice recovery.The findings of this study support the integration of MPT, AVQI, and ABI in clinical practice for a more precise assessment of IL outcomes in patients with UVFP. Future research should involve larger sample sizes to investigate cause-specific recovery rates and the role of postIL voice therapy.
Copyright © 2025 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
Department of Speech-Language Pathology, Kosin University, Busan, South Korea. Electronic address: ahaha1216@gmail.com.
Journal of voice : official journal of the Voice Foundation
Acoustic Analysis for Predicting Voice Recovery Following Injection Laryngoplasty in Patients With Unilateral Vocal Fold Paralysis.
This study aimed (i) to extract videostrobokymograms (VSK) and measure the objective metrics of vocal fold vibration from stroboscopic footage with unsteady laryngeal positions using a customized approach that utilized the Lucas-Kanade optical flow method-alongside other preprocessing methods and kymogram extraction techniques and (ii) to juxtapose the readings of Electroglottography (EGG) with the extracted VSK metrics.Sixty-three tokens of videostroboscopy and EGG were obtained from 21 phononormals. The videostroboscopic samples were then subjected to pre-processing for optimization. From the preprocessed samples, VSK were extracted at three lines of interest, ie, anterior, middle, and posterior region of the vocal folds, using a customized approach. Further, closed quotient was computed from the extracted VSK (VSK CQ) and contact quotient from the EGG waveform (EGG CQ). Wilcoxon signed-rank test and Bland-Altman plot analysis were performed to compare and determine the agreements between VSK and EGG values.VSK obtained in this study were visually similar to the VSK reported in the literature. Mean and SD of EGG CQ was (0.45 ± 0.01), and VSK CQ was (0.46 ± 0.02). The values of VSK CQ differed from the anterior to the posterior portion of the vocal folds, demonstrating variations in movement along its length. Wilcoxon signed-rank test revealed no statistically significant differences between the VSK and EGG measurements. Bland-Altman plot analysis used to compare the agreements between two measurements suggested that VSK values were in agreements with the EGG measurements.The present work offers preliminary evidence that quantifiable objective measures can be calculated even from videostroboscopic footage with unsteady laryngeal positions by tailoring the VSK technique. However, assessing the clinical value of this approach is mandatory.
Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, India. Electronic address: sriranjanivmurali@gmail.com.
Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, India. Electronic address: prakash_boominathan@sriramachandra.edu.in.
Department of Biomedical Engineering, SSN College of Engineering, Chennai, India. Electronic address: pravinkumars@ssn.edu.in.
Department of ENT, Head and Neck Surgery, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, India. Electronic address: somu.l@sriramachandra.edu.in.
Videostrobokymographic Analysis of Stroboscopic Footage With Unsteady Laryngeal Positions From Phononormals.
In a retrospective analysis, data from patients who underwent open revision after ultrasound-guided release between February 2021 and December 2023 were reviewed. These patients experienced persistent, worsened or new symptoms. Clinical symptoms, complications and surgical techniques were assessed. Of 14 patients undergoing revision, nine had an incomplete release of the flexor retinaculum. Five patients had major complications like nerve or vessel lesions. Our findings indicate that although ultrasound-guided release is effective, it should only be done by physicians experienced in nerve sonography and hand surgery.Level of evidence: IV.
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Department of Orthopedic and Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Department of Orthopedic and Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria.Sportklinik Arlberg, St. Anton am Arlberg, Austria.
The Journal of hand surgery, European volume
Complications after ultrasound-guided carpal tunnel release: a case series.
Cadmium (Cd) contamination in aquatic ecosystems poses significant threats to environmental and public health due to its high toxicity and persistence. Even at trace levels, Cd can cause severe health issues, including kidney damage, bone disorders, and an increased risk of cancer, making its detection and monitoring critical. This review focuses on spectrometry techniques for detecting and quantifying Cd in water, evaluating its sensitivity, specificity, and adaptability to diverse environmental conditions. It highlights advancements in modern technologies that enhance the precision, speed, and reliability of these methods while addressing limitations such as high costs and operational complexity. The review also emphasizes the importance of integrating innovative approaches to improve portability and accessibility for real-time monitoring in resource-limited settings. By providing insights into current challenges and potential solutions, this study aims to guide the development of more efficient detection systems that support effective environmental management and safeguard public health from the harmful effects of cadmium contamination.
Electronics and Communication, Vidyavardhaka College of Engineering, Mysuru, India.
Critical reviews in analytical chemistry
Review of Modern Spectrometric Techniques for Monitoring Cadmium in Water and Enhancing Public Health.
Peripheral arterial disease (PAD) causes narrowing of the lower extremity arteries and impacts daily living activities. This retrospective study (April 2023 - April 2024) examined 171 home care patients, with 31.6% diagnosed with PAD. Of these, 37.4% were fully dependent, 36.3% (n = 62) were severely dependent, 16.4% (n = 28) were moderately dependent, 7.0% (n = 12) were mildly dependent, 2.9% (n = 5) were independent, and PAD prevalence was higher among severely dependent patients. Dementia was identified as a significant risk factor for PAD. The high prevalence of PAD among severely dependent individuals suggests a potential link between lifestyle factors and PAD risk. The study highlights the need for further research on whether modifying PAD risk factors can enhance patient independence.
Family Medicine, Samsun Training and Research Hospital, Samsun Turkey.
Family Medicine, Samsun University Faculty of Medicine, Samsun, Turkey.
Radiology, Samsun Training and Research Hospital, Samsun, Turkey.
The impact of lower extremity peripheral arterial disease on activities of daily living in home care patients.
The areas with electrically fractionated potentials (AEFP) during sinus rhythm are related to non-pulmonary vein triggers and may serve as substrates of atrial fibrillation (AF) maintenance. However, the histological properties of these compounds remain unclear. Therefore, we aimed to evaluate the late gadolinium enhancement (LGE) properties of AEFP in patients with AF. We enrolled 15 patients with AF who had undergone LGE magnetic resonance imaging before catheter ablation. AEFP in the left atrium was detected using the HD-Grid and NavX systems after pulmonary vein isolation. We compared LGE properties between AEFP and the surrounding non-fractionated areas (non-AEFP). LGE heterogeneity and density were evaluated through entropy (LGE entropy) and the volume ratio of the enhancement voxel (LGE volume ratio), respectively. Thirty-three AEFP were detected in the left atrium. LGE entropy and LGE volume ratio were significantly higher in AEFP than in non-AEFP [LGE entropy: 6.2 (6.1-6.4) vs. 5.9 (5.8-6.0), p ≤ 0.0001; LGE volume ratio: 23.0% (17.2-29.0%) vs. 10.4% (3.4-20.2%), p ≤ 0.0001]. The atrial voltages did not differ [2.4 (1.3-3.7) vs. 2.5 (1.9-3.1) mV, p = 0.96]. AF recurrence was more significantly found in patients with more than three AEFP than in those without it (log-rank test: p = 0.009). AEFP is likely to be distributed in heterogeneous and moderate LGE areas, regardless of the atrial voltage.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan. kunihikokiuchi@yahoo.co.jp.
Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Late gadolinium enhancement in areas with electrically fractionated potentials during sinus rhythm in patients with atrial fibrillation.
Detailed pre-operative HRCT scan-based measurement of the distance between surgical landmarks with lateral or sigmoid sinus (SS) and classification of its relations with surgical landmarks.Observational Study.Tertiary care center.Patient volunteers above 18 years of age undergoing scans for various reasons.Axial Sections of HRCT of 260 temporal bones obtained from patient volunteers were studied with the help of RadiAnt DICOM Viewer (version 2023.1).Closest distance of the SS from the posterior wall of the external auditory canal wall (CW), the vertical portion of the facial nerve (VPFN), the short process of incus (SPI), lateral (LC), and posterior semi-circular canal (PC), was measured. The SS relation with the mastoid was classified as type 1-4 depending upon the shortest distance of the sinus from the posterior canal wall millimeters.The mean distance of the SS from surgical landmarks was 14.6 ± 2.7 mm for SPI, 11.1 ± 3.1 for CW, 11.4 ± 2.9 for VPFN, 10.1 ± 2.8 for PC, and 11.9 ± 2.7 LC. All measured distances were significantly more on the left side (p < 0.05, Z test), except the difference in distance from LC. The greatest range of variation (5.2 to 21.8 mm) was seen in the distance between SS and VPFN. The most common type of relationship between SS and CW was type 3, present in 64% of subjects, while the least common group was type 1, with nearly 1% of subjects.The assessment of distances and relations of various surgical landmarks with SS, with the proposed novel classification based on SS-CW distance, can be essential for preoperative planning and risk mitigation.
Department of Otorhinolaryngology & Head-Neck Surgery, All India Institute of Medical Sciences, Rishikesh, 814152, Jharkhand, India.
Department of Otorhinolaryngology & Head-Neck Surgery, All India Institute of Medical Sciences, Rishikesh, 814152, Jharkhand, India. abhi04stanley@gmail.com.
Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, 249203, Uttarakhand, India.
Department of Otorhinolaryngology & Head-Neck Surgery, GGS Medical College, Faridkot, 151203, Punjab, India.
Department of Neuro-Surgery, All India Institute of Medical Sciences, Rishikesh, 249203, Uttarakhand, India.
Department of Anatomy, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Eur Arch Otorhinolaryngol. 2025-02-08;():.
Radiological relations of sigmoid sinus with oto-neuro-surgical landmarks with its surgical risk-stratification indicating classification.
Appendectomy, whether open or minimally invasive (MIS) is one of the most frequent procedures performed by young residents. We designed and tested a new methodology and a new inexpensive silicone model for Laparoscopic Appendectomy (LA) simulation. This study aimed to assess their fidelity, usefulness and educational value in an introduction to laparoscopy course. The course was open to first-year general surgery residents. The group was divided in two and one of the groups watched a video of the procedure before the simulation. Individual performances were assessed directly on the models, using a specific assessment scale. Participants answered a questionnaire at the end of the course for evaluation. Thirty-five residents participated in this study. Execution, quality, and global performance were higher in the group that had more experience with the model. Thirty-two trainees (91%) answered the questionnaire. There was a strong agreement that the model was adequate for this type of course and face and content validity was considered high/very high. Participants strongly agreed that this model gives more confidence to perform a real LA and almost 97% (n = 31) considered they have learned solid foundations about LA. This study shows face, content and construct validation and also educational value for this new low-cost, laparoscopic appendectomy model. The integration of this model in an introduction to laparoscopy course showed good results in regard to an increase of confidence among first-year surgery residents. It can be a valuable tool for learning and training laparoscopic appendectomy.
Centro Académico Clínico das Beiras (Academic Clinical Center of Beiras), Faculty of Health Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal. marioruig@gmail.com.
Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.
Centro Hospitalar Barreiro Montijo, Avenida Movimento das Forças Armadas, 2830-003, Barreiro, Portugal.
Hospital Central do Funchal, Avenida Luís de Camões nº 57, 9004-514, Funchal, Portugal.
Serviço de Cirurgia Geral, Unidade Local de Saúde de Castelo Branco, Hospital Amato Lusitano, Av. Pedro Alvares Cabral 3, 6000-085, Castelo Branco, Portugal.
Serviço de Cirurgia Geral, Unidade Local de Saúde de São José, Lisbon, Portugal.
Serviço de Cirurgia Geral, Unidade Local de Saúde do Baixo Alentejo, Beja, Portugal.
Centro Académico Clínico das Beiras (Academic Clinical Center of Beiras), Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal.
LapAppendectomy4all: validation of a new methodology for laparoscopic appendectomy simulation and training.
Mohammed Bin Rashid University, Dubai, UAE. romeqgiezen@gmail.com.
Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia.
International journal of impotence research
Individualised shockwave therapy for erectile dysfunction: importance of establishing precise therapeutic range.
This study investigated the microbial community composition and structure in healthy and diseased rhubarb (Rheum rhabarbarum) root systems, examining both root tissue and rhizosphere environments. Alpha diversity analysis revealed significantly higher microbial abundance in the rhizosphere compared to root tissues, with notable differences between healthy and diseased plants. Principal coordinate analysis demonstrated that bacterial community composition was primarily influenced by ecological niches (47.5% variation explained), whereas fungal communities segregated based on plant health status. Network analysis revealed increased bacterial community complexity in diseased plants rhizosphere (579 nodes, 13,016 edges) compared to healthy plants (542 nodes, 8700 edges), while fungal networks showed opposite trends with significant reduction in diseased conditions (147 nodes, 30 edges vs. 205 nodes, 418 edges). Correlation analysis identified significant associations between specific microbial taxa and soil properties, with notable positive correlations between certain bacteria (Oscillospirales) and fungi (Barnettozyma, Mortierella) with soil organic matter and nutrient availability. Pathogenic taxa, including Fusarium and members of Burkholderiales, showed negative correlations with beneficial microorganisms, suggesting potential antagonistic relationships. These findings provide crucial insights into the complex interactions within the rhubarb root microbiome and their implications for plant health, contributing to our understanding of root rot disease dynamics and potential management strategies.
College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Department of Ecological Environmental Engineering, Yangling Vocational and Technical College, Yangling, Shaanxi, China.
Zhenba County Lijian Traditional Chinese Medicine Professional Cooperative, Hanzhong, Shaanxi, China.
Zhenba County Science and Technology Progress Promotion Center, Hanzhong, Shaanxi, China.
College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, China. yatuanma@nwsuaf.edu.cn.
Unraveling the Rhubarb (Rheum officinale Baill.) Root and Rhizosphere Microbial Communities in Response to Pathogen Exposure.
School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.Veteran Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Veteran Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.Division of Pulmonary, Allergy, Critical Care Medicine and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA USA.
PAP Therapy Lowers Healthcare Costs in Older Adults, but Initiation Remains a Challenge.
This paper presents a basic model for the therapeutic effect of two drugs on patients with early cervical cancer. Two cases are considered: with constant control and with optimal control. For case one, the system is proved to have a unique non-negativity solution if the initial values are positive; then the sufficient conditions for the existence and stability of the equilibriums are derived; and Hopf bifurcation is also considered. For case two, by using the Pontryagin's Maximum Principle, we get the optimal control solution. Some examples and numerical simulations are presented. Discussions and conclusions are listed at the end.
School of Mathematics and Computer Science, Shanxi Normal University, Taiyuan, China.
Computer methods in biomechanics and biomedical engineering
Comput Methods Biomech Biomed Engin. 2025-02-08;():1-25.
Stability, Hopf bifurcation and control of a fractional order delay cervical cancer model with HPV infection.
Department of Dermato-Venereology, 4th Military Hospital, Wroclaw, Poland.Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland.
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Artificial Intelligence in the Exploration and Treatment of Itch/Pruritus.
Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Treatment of Lichen Planopilaris With Abrocitinib.
The prevalence of food insecurity (FI) on university campuses is increasing. This study explored the prevalence of food and nutrition insecurity (NI) among dental students and barriers and interventions to address them.A cross-sectional web-based survey was conducted. Validated tools were used to assess FI and NI. Univariate binary logistic regressions and a multivariable logistic regression model identified factors independently associated with FI.The response rate was 11.9% (n = 67). The mean age was 28.4 years; 67% were D1/D2 students; 53.7% were female, 15.2% identified as Hispanic, and 50.7% as White. Forty percent experienced FI; 24.2% had low nutrition security (NS), and 26.9% reported partial or full responsibility for others' living expenses. Twenty-four percent were married, 25.8% used a food pantry; 11.1% had unsuccessfully applied for Supplemental Nutrition Assistance Program benefits. In the adjusted model, low NS, nonmarried status, and food pantry use increased the likelihood of FI (odds ratios of 16.854, 10.182, and 9.123, respectively). Common barriers and potential interventions to address FI and NI were explored.The prevalence of FI in this sample was greater than the national average. Those who were unmarried, had low NS, and used a food pantry were significantly more likely to have FI. Proposed interventions include student services enhancements and curriculum modifications on nutrition and wellness. Further research is necessary with a larger sample to understand factors contributing to NI and FI among dental students.
© 2025 The Author(s). Journal of Dental Education published by Wiley Periodicals LLC on behalf of American Dental Education Association.
Rutgers School of Health Professions and Rutgers School of Dental Medicine, Newark, New Jersey, USA.Community Health, Rutgers School of Dental Medicine, Newark, New Jersey, USA.
Community Health, Rutgers School of Dental Medicine, Newark, New Jersey, USA.
Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Newark, New Jersey, USA.
University of Iowa College of Dentistry, Iowa City, Iowa, USA.
Rutgers School of Health Professions, Newark, New Jersey, USA.
Interventions to Reduce Food and Nutrition Insecurity Among Dental Students.
Graduate student, Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Assistant Professor, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Assistant Professor, Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Integrating Generative AI in Case-Based Collaborative Learning: Student's Perceptions.
Granuloma annulare (GA) is a non-infectious, granulomatous skin disease with an unknown pathoetiology whose treatment remains challenging. In recent decades, the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have been implicated in the pathogenesis of various skin diseases, including GA. This pathway involves T-helpers and macrophages, launching a cytokine cascade that plays a crucial role in the disease pathology. Janus kinase (JAK) inhibitors can prevent cytokine involvement. To date, limited clinical data has been reported about the effectiveness of JAK inhibitors on granulomatous diseases. This review aims to examine studies that have reported off-label use of different JAK inhibitors in treating GA, focusing on their effectiveness and safety. Since there is no definitive treatment for GA, evaluating the role of JAK inhibitors could help establish a consensus on their future use in this type of medication.
© 2025 the International Society of Dermatology.
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Emerging Role of Janus Kinase Inhibitors in Treating Granuloma Annulare: A Clinical, Narrative Review of Efficacy and Safety.
Over time, surrogacy has become more broadly available to a variety of people (e.g. male same-sex couples or transgender women). Whether the wider public supports surrogacy, and what contributes to such support remains unclear. This study investigated what demographic and surrogacy arrangement-based (which people participate in the arrangement) factors shape attitudes towards surrogacy.A representative sample of Dutch adults (N = 1,074) reported their attitudes on four (out of 30) randomly assigned vignettes in 2023. Each vignette described a surrogacy family with variations in sexuality and gender of parents, the social and genetic bonds between the parents, the surrogate, and the oocyte donor, and was followed by an attitude questionnaire (6 items). Multilevel regression analyses were conducted with attitudes as the dependent variable and demographic factors (gender, Dutch background, age, education, sexual orientation, urbanisation, and religiosity) and arrangement-based factors (parental composition, genetic and social bonds with the surrogate, and oocyte donors).Participants held fairly positive attitudes towards surrogacy. People identifying as women, with only having a Dutch background, who were younger, more highly educated, non-heterosexual, or less religious were more likely to have positive attitudes. Participants had more positive attitudes if surrogacy arrangements entailed cis-man cis-woman parents compared to cis-man cis-man or transgender parents, and when there was no social bond between parents and oocyte donor.Attitudes are influenced by both demographic and arrangement-based factors. Based on these findings, families can be informed of fairly positive reactions they might encounter from their environment.
Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, the Netherlands.
Department of Sociology, Utrecht University, Utrecht, the Netherlands.
Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, the Netherlands.Faculty of Education, Amsterdam University of Applied Sciences, Amsterdam, the Netherlands.
Amsterdam UMC, Centre for Reproductive Medicine, Amsterdam, the Netherlands.
J Reprod Infant Psychol. 2025-02-09;():1-11.
Demographic and arrangement-based predictors of Dutch people's attitudes towards surrogacy in various family constitutions.
The growing popularity of electronic cigarettes (e-cigarettes) among Indonesian youth presents a new public health challenge in a country with one of the highest tobacco burdens globally. While tobacco control regulations have been implemented, e-cigarettes remain largely unregulated, raising concerns about their health impacts and youth appeal. This study explores the prevalence, determinants and perceptions of e-cigarette use among high school and university students in Indonesia, providing critical insights to inform effective policymaking. A cross-sectional online-based survey was conducted in 2019 among 158 students aged 15-30 years across 17 provinces in Indonesia. Data on tobacco use behaviours, socioeconomic background, social influences and health perceptions were collected. Descriptive and inferential statistical analyses identified key determinants of e-cigarette use. Among the participants, 36.2% reported ever smoking, and 65.2% of these had tried e-cigarettes. Key determinants of e-cigarette use included male gender, urban residency, peer smoking and social acceptance of smoking (all p < 0.05). Notably, participants commonly perceived e-cigarettes as less harmful than combustible cigarettes and helpful for smoking cessation, despite conflicting scientific evidence. Overall, e-cigarette use is prevalent among Indonesian youth, driven by social and environmental factors, as well as misconceptions about safety. Strengthened regulations and targeted public health campaigns are essential to mitigate the health risks posed by e-cigarettes and enhance tobacco control efforts.
Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, Munich, Germany. razan.wibowo@med.uni-muenchen.de.Institute for Medical Information Processing, Biometry and Epidemiology (IBE), LMU Munich, Munich, Germany. razan.wibowo@med.uni-muenchen.de.Pettenkoffer School of Public Health, Munich, Germany. razan.wibowo@med.uni-muenchen.de.Comprehensive Pneumology Centre (CPC) Munich, Member of German Centre for Lung Research (DZL), Munich, Germany. razan.wibowo@med.uni-muenchen.de.
Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, Munich, Germany.Comprehensive Pneumology Centre (CPC) Munich, Member of German Centre for Lung Research (DZL), Munich, Germany.
Department of Health Behaviour, Environmental, and Social Medicine (HBES), Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Exploring E-Cigarette Use Among Indonesian Youth: Prevalence, Determinants and Policy Implications.
Tetralogy of Fallot often requires transannular patch repair, leading to pulmonary insufficiency. Percutaneous pulmonary valve implantation (PPVI) with self-expandable valves offers a promising alternative, especially for enlarged right ventricular Queryoutflow tracts (RVOT). Five RVOT types identified in patients with Tetralogy of Fallot reflect anatomical variations due to disease and prior surgeries. This study assesses the Pulsta THV® valve's in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. Five RVOT morphologies were recreated as 3D models from patient-specific imaging data. The Pulsta THV® valves, available in 28, 30, and 32 mm sizes, were evaluated using the ViVitro Pulse Duplicator System at three cardiac outputs (2, 3.5, and 5 L/min). Hemodynamic performance was assessed by measuring regurgitation rates and pressure gradients in the left and right pulmonary arteries. The Pulsta THV® performed optimally in RVOT Types 1 and 2, demonstrating lower regurgitation rates and pressure gradients, particularly with larger valve sizes. Conversely, RVOT Types 3 and 5 showed increased pressure gradients and hemodynamic variability, indicating less favorable outcomes. The results highlighted the critical role of precise anatomical compatibility, with larger valve sizes proving more effective in enlarged RVOT geometry. Valve sizes tailored to specific RVOT morphologies can enhance PPVI outcomes. Types 1 and 2 are ideal for PPVI, while Types 3 and 5 present challenges due to hemodynamic variability. This study supports 3D modeling and in vitro testing for pre-procedural planning to reduce complications, with future research exploring dynamic imaging and materials mimicking tissue properties.
Faculty of Medicine, Department of Pediatric Cardiology, Koc University, Istanbul, Turkey. eodemis@kuh.ku.edu.tr.Graduate School of Science and Engineering Department of Biomedical Science and Engineering, Koc University, Istanbul, Turkey. eodemis@kuh.ku.edu.tr.
Faculty of Engineering and Natural Sciences, Department of Mechatronics Engineering, İstanbul Bilgi University, Istanbul, Turkey.
Faculty of Medicine, Department of Pediatric Cardiology, Koc University, Istanbul, Turkey.
3D Modeling of Self-Expandable Valves for PPVI in Distinct RVOT Morphologies.
International Longevity Centre Singapore, Tsao Foundation, Singapore.
Advancing gerontology through intergenerational equity, social quality and healthy longevity.