[Conventional vs. CT Data-Based Three-Dimensional Measurement of Nasal Septum Defects].
pmid: 39947637
abstract: Septal perforations can severely diminish quality of life. Where surgical closure is impossible, due to size, location or contraindications, septum obturators offer an alternative. Defect anatomy can be assessed two ways: analog via silicone impression, or digitally using preoperative CT scans. This study compares these two methods.Retrospective analysis of 500 patients with symptomatic septal perforations was carried out, including defect size and location, type of closure and closure rate in surgical closures. 19 patients qualified for comparison of defect size and shape determined by conventional impression with CT-based data. For high precision comparison, silicone impressions were converted into plaster models, then digitally scanned, and CT data was converted into 3D models.The analysis of the NSD in the 19 patients and the comparison of the results from analog silicone impressions and preoperative CT scans revealed deviations of less than 10% in 8 out of 19 cases and less than 20% in 13 out of 19 cases. The deviations tended to be smaller in cases of larger defects. Larger deviations were observed when there were longer time intervals between the impression and the CT scan.Measurements of NSD based on CT data yield similar results to those obtained from silicone impressions, particularly when the CT scans are performed in close temporal proximity and in cases of larger defects. Further clinical studies should investigate whether iSOs created from CT data result in comparable clinical patient acceptance.
rights: Thieme. All rights reserved.
doi: 10.1055/a-2508-3921
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Heimbach C
      type: Person
      first name: Cedric
      last name: Heimbach
      member of: Klinik für Mund-Kiefer- und Gesichtschirurgie, Evangelisches Krankenhaus Bethesda Mönchengladbach, Mönchengladbach, Germany.
  slot:
    index: 2
    item: Velten B
      type: Person
      first name: Benjamin
      last name: Velten
      member of: Institut für Anaplastologie, Institut für Anaplastologie Velten & Hering OHG, Genthin, Germany.
  slot:
    index: 3
    item: Neumann A
      type: Person
      first name: Andreas
      last name: Neumann
      member of: Hals-Nasen-Ohren-Klinik, Rheinland Klinikum Neuss GmbH, Neuss, Germany.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:03
e ISSN: 1438-8685
has issn l: 0935-8943
has NLM journal title abbreviation: Laryngorhinootologie
publication name: Laryngo- rhino- otologie
language: ger
has national library of medicine journal id: 8912371
rights holder: Nasenseptumdefekte (NSD) können zu einer deutlichen Einschränkung der Lebensqualität führen. Ist der operative Verschluss aufgrund von Defektgröße, -lage oder individueller Kontraindikationen nicht möglich, stehen Septumobturatoren zur Verfügung. Die Erfassung der Defektkonfiguration kann analog per Silikonabdruck und digital anhand eines präoperativen CTs erfolgen. Ziel dieser Studie ist der Vergleich dieser beiden Methoden.Retrospektiv wurden 500 Patienten mit symptomatischen NSD analysiert. Erfasst wurden u.a. Größe und Lage des Defekts, Art des operativen Verschlusses und die Verschlussrate bei operativem Verschluss. Bei 19 Patienten war es möglich, die mit einem konventionellen Abdruck ermittelte Defektgröße und Form mit CT-basierten Daten zu vergleichen. Dazu wurde der Silikonabdruck in ein Gipsmodell überführt und in einem Modellscanner digitalisiert. Die CT-Daten wurden ebenfalls in ein 3D-Modell konvertiert und die Defektgröße ermittelt. Durch dieses Verfahren war ein Vergleich bis auf den hundertstel Millimeter möglich.Die Auswertung der NSD der 19 Patienten und der Vergleich der Ergebnisse von analogen Silikonabformungen und präoperativen CTs zeigten Abweichungen in 8 von 19 Fällen kleiner 10% und in 13 von 19 Fällen kleiner 20%, wobei die Abweichung bei größeren Defekten tendenziell geringer ausfiel. Größere Abweichungen lagen vor allem bei zeitlich längeren Abständen zwischen Abformung und CT vor.Die auf CT-Daten basierte Vermessung von NSD kommt vor allem bei zeitnah erfolgten CTs und größeren Defekten zu ähnlichen Ergebnissen wie die anhand von Silikonabdrücken erfolgten Messungen. Weitere klinische Studien sollten untersuchen, ob anhand von CT-Daten erstellte iSO zu einer ähnlichen klinischen Patientenakzeptanz führen.
derived from: NLM
has place of publication: Germany
source: Laryngorhinootologie. 2025-02-13;():.

The context, mechanisms and outcomes of intergenerational programmes involving people living with dementia in scotland: A realist, qualitative study.
pmid: 39947634
abstract: Intergenerational programmes, involving activity-based interventions designed to promote mutually beneficial interactions between participants, have been used in Scotland and further afield as a means of generating social inclusion between different age groups. There is growing interest in the potential outcomes of intergenerational programmes for people living with dementia in particular, with policy in Scotland recognising that people living with dementia and their carers may be at greater risk of loneliness and social isolation. Given this interest, there is a need to explore what 'intergenerational best practice' may look like for people living with dementia. Using data from semi-structured interviews with thirteen stakeholders involved in intergenerational practice and/or dementia policymaking, this study explored the contextual factors, mechanisms, and outcomes of intergenerational programmes in the Scottish context. Stakeholders perceived the concerns of carers, perceptions of risk, along with inaccessible venues and transportation to be important contextual factors. Mechanisms that helped ensure programmes offered full and appropriate participation opportunities included ongoing, flexible programme planning; the provision of purpose and roles; and the use of older participants' preferences, lived experience, and personhood. Overall intergenerational programmes were perceived to have the potential to promote beneficial outcomes for older participants living with dementia in Scotland.
doi: 10.1177/14713012251317767
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Emond H
      type: Person
      first name: Heather
      last name: Emond
      member of: Queen Margaret University, Scotland.Faculty of Social Sciences, University of Stirling, UK.
  slot:
    index: 2
    item: Kelly F
      type: Person
      first name: Fiona
      last name: Kelly
      member of: Queen Margaret University, Scotland.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T19:42
e ISSN: 1741-2684
has issn l: 1471-3012
has NLM journal title abbreviation: Dementia (London)
publication name: Dementia (London, England)
language: eng
has national library of medicine journal id: 101128698
derived from: NLM
pg: 14713012251317767
has place of publication: England
source: Dementia (London). 2025-02-13;():14713012251317767.

http://rdf.ncbi.nlm.nih.gov/pubmed/39947628
pmid: 39947628
doi: 10.1055/a-2510-9950
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Bechrakis NE
      type: Person
      first name: Nikolaos E
      last name: Bechrakis
  slot:
    index: 2
    item: Joussen A
      type: Person
      first name: Antonia
      last name: Joussen
  slot:
    index: 3
    item: Heimann H
      type: Person
      first name: Heinrich
      last name: Heimann
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T19:34
e ISSN: 1439-3999
has issn l: 0023-2165
issue: 2
has NLM journal title abbreviation: Klin Monbl Augenheilkd
publication name: Klinische Monatsblatter fur Augenheilkunde
language: ger
has national library of medicine journal id: 0014133
derived from: NLM
pg: 97
has place of publication: Germany
source: Klin Monbl Augenheilkd. 2025-02;242(2):97.
volume: 242

Development of a Thioetherification of Heteroarene Electrophiles with Broad Scope via a Proton Transfer Dual Ionization Mechanism.
pmid: 39947636
abstract: Sulfur-derived functional groups represent prevalent motifs in highly sought-after small molecules, such as active pharmaceutical ingredients (APIs). Thioethers are one such example, being commonly encountered in APIs, prodrugs, and as valuable synthetic linchpins to access an array of sulfur-derived functional groups. While nucleophilic aromatic substitution (SNAr) has traditionally been used to synthesize aryl thioethers, modern approaches leverage transition metals to catalyze thermal or photochemical cross-coupling. While studying photochemical thioetherification reactions, we uncovered a remarkably mild condition that does not require light, transition metals, or exogenous bases. An array of thiols and halogenated heterocycles were coupled to produce >70 diverse products. Reaction progress kinetic analysis (RPKA) and computational studies support a unique mechanism termed proton transfer dual ionization (PTDI) SNAr. Finally, a predictive statistical model was constructed aided by high-throughput experimentation (HTE) to understand when the PTDI processes are successful, resulting in the completion of ten target-oriented syntheses. This transformation complements modern approaches to thioether synthesis and motivates additional research evaluating PTDI as a general activation mode between reaction partners.
doi: 10.1021/jacs.4c18304
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Zwick CR
      type: Person
      first name: Christian R
      last name: Zwick
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 2
    item: Eckhoff M
      type: Person
      first name: Maike
      last name: Eckhoff
      member of: Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
  slot:
    index: 3
    item: Henle JJ
      type: Person
      first name: Jeremy J
      last name: Henle
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 4
    item: Bay AV
      type: Person
      first name: Anna V
      last name: Bay
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 5
    item: Swiatowiec R
      type: Person
      first name: Rafal
      last name: Swiatowiec
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 6
    item: Shekhar S
      type: Person
      first name: Shashank
      last name: Shekhar
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 7
    item: Yang C
      type: Person
      first name: Cassie
      last name: Yang
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 8
    item: Zhou Y
      type: Person
      first name: Yong
      last name: Zhou
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 9
    item: Wall AL
      type: Person
      first name: Amanda L
      last name: Wall
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 10
    item: Henry RF
      type: Person
      first name: Rodger F
      last name: Henry
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 11
    item: Hoskins JN
      type: Person
      first name: Jessica N
      last name: Hoskins
      member of: AbbVie Process Research & Development, 1401 N. Sheridan Road, North Chicago, Illinois 60064, United States.
  slot:
    index: 12
    item: Sigman MS
      type: Person
      first name: Matthew S
      last name: Sigman
      member of: Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T19:52
e ISSN: 1520-5126
has issn l: 0002-7863
has NLM journal title abbreviation: J Am Chem Soc
publication name: Journal of the American Chemical Society
language: eng
has national library of medicine journal id: 7503056
derived from: NLM
has place of publication: United States
source: J Am Chem Soc. 2025-02-13;():.

Optimal Strategies for the Management of Macromastia and Breast Ptosis for Patients Undergoing Nipple-sparing Mastectomy.
pmid: 39947639
abstract: High-volume breasts pose challenges for nipple-sparing mastectomy (NSM) due to their large size, indistinct tissue boundaries, and high degree of ptosis. Historically, NSM was not considered feasible for such cases, but advancements in surgical techniques have expanded eligibility criteria.We developed a surgical algorithm for patients with macromastia and ptosis undergoing NSM. We also outline techniques for preserving the nipple-areolar complex (NAC) based on the severity of macromastia and breast ptosis, especially when immediate mastopexy/reduction is required during mastectomy. The proposed algorithm provides a practical guide for surgeons managing these complex cases.By employing carefully selected approaches, it is possible to successfully preserve the NAC in high-volume breasts undergoing NSM. This broader eligibility criteria not only accommodates a more diverse patient population but also enhances their quality of life and improves aesthetic outcomes.Advancements in surgical techniques have made NSM a viable option for breast reconstruction in high-volume breasts. By addressing challenges and preserving the NAC through carefully selected approaches, surgeons can improve outcomes and quality of life for patients undergoing NSM.
rights: Thieme. All rights reserved.
doi: 10.1055/a-2508-6495
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Moreira AA
      type: Person
      first name: Andrea A
      last name: Moreira
      member of: Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.Department of Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania.
  slot:
    index: 2
    item: Kozorosky E
      type: Person
      first name: Erica
      last name: Kozorosky
      member of: Department of Surgery, St. Joseph's University Medical Center, Paterson, New Jersey.
  slot:
    index: 3
    item: Coopey SB
      type: Person
      first name: Suzanne B
      last name: Coopey
      member of: Department of Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:03
e ISSN: 1098-8947
has issn l: 0743-684X
has NLM journal title abbreviation: J Reconstr Microsurg
publication name: Journal of reconstructive microsurgery
language: eng
has national library of medicine journal id: 8502670
derived from: NLM
has place of publication: United States
source: J Reconstr Microsurg. 2025-02-13;():.

Evaluating the Impact of Folate on Male Infertility Using Mendelian Randomization: A Comprehensive Analysis.
pmid: 39947651
abstract: In recent decades, the incidence of male infertility has been increasing annually. In clinical practice, the question of whether to supplement folic acid is common among patients. Given the limited guidelines and research on the impact of folic acid on male infertility, this study aims to assess the effect of folic acid on male infertility using Mendelian randomization (MR) analysis.We conducted a two-sample bidirectional MR study using IEU database data for folate levels and supplementation. Male infertility genome-wide association study (GWAS) data were obtained from the FinnGen Consortium R8 dataset. To evaluate the causal relationship between folate, folate supplementation, and the risk of male infertility, we employed various MR methods, including inverse-variance weighted (IVW), MR-Egger, and Maximum Likelihood. The analysis results were assessed using MR-PRESSO, MR-Egger, and leave-one-out analysis. Genes related to folate metabolism were sourced from the MSigDB database, and the Expression Quantitative Trait Loci (eQTL) information of related genes was obtained from the IEU database. Single nucleotide polymorphism data for other male infertility risk factors, such as diabetes and obesity, were also analyzed.According to the MR analysis, there is no causal relationship between serum folate levels and male infertility in the general population. However, reverse Mendelian analysis indicated that male infertility may promote elevated serum folate levels. Folate supplementation appears to act as a protective factor against male infertility, while reverse MR analysis shows no causal relationship between male infertility and folate supplementation. Furthermore, we identified SERPINE1 and LDLR as potential causal genes in the folate metabolism pathway related to male infertility. Hypertension and hyperlipidemia also showed causal relationships with these two genes.This study used MR to discover that folate supplementation is a protective factor against male infertil[cell cut: 2105 characters, first 2000 kept]
rights: Copyright © 2025 Korean Society for Sexual Medicine and Andrology.
has PII: 43.e8
doi: 10.5534/wjmh.240252
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Wang W
      type: Person
      first name: Weizhuo
      last name: Wang
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  slot:
    index: 2
    item: Chen K
      type: Person
      first name: Kang
      last name: Chen
      member of: Department of Urology, Nanjing Gaochun Hospital of Traditional Chinese Medicine, Nanjing, China.
  slot:
    index: 3
    item: Yu Y
      type: Person
      first name: Yi
      last name: Yu
      member of: Department of Reproductive Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China.
  slot:
    index: 4
    item: Chen M
      type: Person
      first name: Mingwei
      last name: Chen
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  slot:
    index: 5
    item: Wang L
      type: Person
      first name: Lu
      last name: Wang
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  slot:
    index: 6
    item: Pang Y
      type: Person
      first name: Ying
      last name: Pang
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  slot:
    index: 7
    item: Ren M
      type: Person
      first name: Meiqi
      last name: Ren
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  slot:
    index: 8
    item: Zhang H
      type: Person
      first name: Hong
      last name: Zhang
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China. szzhanghong126@126.com.
  slot:
    index: 9
    item: Fu K
      type: Person
      first name: Kai
      last name: Fu
      member of: Center for Reproductive Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China. fukai2704@suda.edu.cn.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-01-22
dp: 2025 Jan 22
created: 2025-2-13T20:23
ISSN: 2287-4208
has issn l: 2287-4208
has NLM journal title abbreviation: World J Mens Health
publication name: The world journal of men's health
language: eng
has national library of medicine journal id: 101596899
derived from: NLM
has place of publication: Korea (South)
source: World J Mens Health. 2025-01-22;():.

Impact of Prostate Cancer Treatment on Quality of Life of LGBTQ+ Patients: A Systematic Review.
pmid: 39947650
abstract: The gay, bisexual, transgender, and queer + (LGBTQ+) community is underserved, and their needs are often misunderstood and/or overlooked. We aimed to analyze the current literature regarding prostate cancer's (PCa) impact on the quality of life (QoL) of LGBTQ+ patients with a focus on sexuality, identity, and psychosocial support. In June 2024, we searched the following databases, PubMed, Embase, and Clinicaltrials.gov, for relevant data regarding sexuality, identity, and psychosocial support of LGBTQ+ suffering from PCa using the keywords Prostate Cancer AND Gay or Prostate Cancer AND LGBTQ+. In sum, there were only a few records on the subject with very few clinical trials. Major concerns of inadequate care included the impact on sexual intercourse, sexual identity and role, mental health, and psychological support. Two U.S. trials reported on the deep health-related quality of LGBTQ+ community members in dealing with PCa. These revealed significant sufferings and disparities in care access, delivery, perception, and satisfaction in the LGBTQ+ patients affected by PCa. Current data suggest that LGBTQ+ patients with PCa are an under-researched population whose QoL concerns and needs are often overlooked. PCa has a significant impact on the sexual, emotional, and social well-being of the LGBTQ+ community; this impact seems different than the non-LGBTQ+ community, underlying the need for focused research and interventions.
rights: Copyright © 2025 Korean Society for Sexual Medicine and Andrology.
has PII: 43.e7
doi: 10.5534/wjmh.240203
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Vartolomei L
      type: Person
      first name: Liliana
      last name: Vartolomei
      member of: Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 2
    item: Petrov P
      type: Person
      first name: Patrik
      last name: Petrov
      member of: Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 3
    item: Vartolomei MD
      type: Person
      first name: Mihai Dorin
      last name: Vartolomei
      member of: Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.Doctoral School, GE Palade University of Medicine, Pharmacy, Sciences and Technology from Târgu Mureş, Targu Mures, Romania.
  slot:
    index: 4
    item: Shariat SF
      type: Person
      first name: Shahrokh F
      last name: Shariat
      member of: Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan.Karl Landsteiner Society, Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria.Department of Urology, Weill Cornell Medical College, New York, NY, USA.Department of Urology, University of Texas Southwestern, Dallas, TX, USA. Shahrokh.shariat@meduniwien.ac.at.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-01-22
dp: 2025 Jan 22
created: 2025-2-13T20:22
ISSN: 2287-4208
has issn l: 2287-4208
has NLM journal title abbreviation: World J Mens Health
publication name: The world journal of men's health
language: eng
has national library of medicine journal id: 101596899
derived from: NLM
has place of publication: Korea (South)
source: World J Mens Health. 2025-01-22;():.

Wales to crack down on junk food promotions to tackle obesity.
pmid: 39947660
doi: 10.1136/bmj.r316
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: O'Dowd A
      type: Person
      first name: Adrian
      last name: O'Dowd
      member of: London.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:42
e ISSN: 1756-1833
has issn l: 0959-8138
has NLM journal title abbreviation: BMJ
publication name: BMJ (Clinical research ed.)
language: eng
has national library of medicine journal id: 8900488
derived from: NLM
pg: r316
has place of publication: England
source: BMJ. 2025-02-13;388():r316.
volume: 388

New UK asthma guideline: meeting the challenge to change.
pmid: 39947665
doi: 10.1136/bmj.r262
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wang K
      type: Person
      first name: Kay
      last name: Wang
      member of: Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK.
  slot:
    index: 2
    item: Ryott G
      type: Person
      first name: Graham
      last name: Ryott
      member of: Patient author, Solihull, UK.
  slot:
    index: 3
    item: Kurukulaaratchy RJ
      type: Person
      first name: Ramesh J
      last name: Kurukulaaratchy
      member of: Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:43
e ISSN: 1756-1833
has issn l: 0959-8138
has NLM journal title abbreviation: BMJ
publication name: BMJ (Clinical research ed.)
language: eng
has national library of medicine journal id: 8900488
derived from: NLM
pg: r262
has place of publication: England
source: BMJ. 2025-02-13;388():r262.
volume: 388

Lucy Letby: What next for the case after an expert panel found no evidence of murder?
pmid: 39947673
doi: 10.1136/bmj.r300
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Mahase E
      type: Person
      first name: Elisabeth
      last name: Mahase
      member of: The BMJ.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:43
e ISSN: 1756-1833
has issn l: 0959-8138
has NLM journal title abbreviation: BMJ
publication name: BMJ (Clinical research ed.)
language: eng
has national library of medicine journal id: 8900488
derived from: NLM
pg: r300
has place of publication: England
source: BMJ. 2025-02-13;388():r300.
volume: 388

Nottingham NHS Trust is fined £1.6m for failings related to three baby deaths.
pmid: 39947670
doi: 10.1136/bmj.r308
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Dyer C
      type: Person
      first name: Clare
      last name: Dyer
      member of: The BMJ.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:43
e ISSN: 1756-1833
has issn l: 0959-8138
has NLM journal title abbreviation: BMJ
publication name: BMJ (Clinical research ed.)
language: eng
has national library of medicine journal id: 8900488
derived from: NLM
pg: r308
has place of publication: England
source: BMJ. 2025-02-13;388():r308.
volume: 388

Structural composition of airway wall fat in healthy weight and overweight/obese subjects.
pmid: 39947686
has PII: 13993003.01772-2024
doi: 10.1183/13993003.01772-2024
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Wang CJ
      type: Person
      first name: Carolyn J
      last name: Wang
      member of: School of Human Sciences, The University of Western Australia, Crawley, Australia.
  slot:
    index: 2
    item: Noble PB
      type: Person
      first name: Peter B
      last name: Noble
      member of: School of Human Sciences, The University of Western Australia, Crawley, Australia.
  slot:
    index: 3
    item: Logan JS
      type: Person
      first name: Jack S
      last name: Logan
      member of: School of Human Sciences, The University of Western Australia, Crawley, Australia.
  slot:
    index: 4
    item: Cairncross A
      type: Person
      first name: Alvenia
      last name: Cairncross
      member of: School of Human Sciences, The University of Western Australia, Crawley, Australia.Department of Pulmonary Physiology and Sleep Medicine, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia.
  slot:
    index: 5
    item: James AL
      type: Person
      first name: Alan L
      last name: James
      member of: Department of Pulmonary Physiology and Sleep Medicine, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia.Medical School, The University of Western Australia, Nedlands, Australia.
  slot:
    index: 6
    item: Elliot JG
      type: Person
      first name: John G
      last name: Elliot
      member of: School of Human Sciences, The University of Western Australia, Crawley, Australia.Department of Pulmonary Physiology and Sleep Medicine, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Australia.Indicates co-senior authors.
  slot:
    index: 7
    item: Wang KCW
      type: Person
      first name: Kimberley C W
      last name: Wang
      member of: School of Human Sciences, The University of Western Australia, Crawley, Australia kimberley.wang@uwa.edu.au.The Kids Research Institute Australia, The University of Western Australia, Nedlands, Australia.Indicates co-senior authors.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T20:44
e ISSN: 1399-3003
has issn l: 0903-1936
issue: 2
has NLM journal title abbreviation: Eur Respir J
publication name: The European respiratory journal
language: eng
has national library of medicine journal id: 8803460
derived from: NLM
has place of publication: England
source: Eur Respir J. 2025-02;65(2):.
volume: 65

Fighting to Eliminate Burnout: A 3-Decade Journey and the Path Forward.
pmid: 39947691
has PII: 00005650-202503000-00001
doi: 10.1097/MLR.0000000000002120
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Linzer M
      type: Person
      first name: Mark
      last name: Linzer
      member of: Department of Medicine, Institute for Professional Worklife, Hennepin Healthcare and the University of Minnesota, Minneapolis, MN.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-13T20:44
e ISSN: 1537-1948
has issn l: 0025-7079
issue: 3
has NLM journal title abbreviation: Med Care
publication name: Medical care
language: eng
has national library of medicine journal id: 0230027
derived from: NLM
starting page: 183
ending page: 184
has place of publication: United States
source: Med Care. 2025-03-01;63(3):183-184.
volume: 63

US health agencies ordered to reinstate webpages removed after Trump's executive order.
pmid: 39947679
doi: 10.1136/bmj.r321
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Wise J
      type: Person
      first name: Jacqui
      last name: Wise
      member of: Kent.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:43
e ISSN: 1756-1833
has issn l: 0959-8138
has NLM journal title abbreviation: BMJ
publication name: BMJ (Clinical research ed.)
language: eng
has national library of medicine journal id: 8900488
derived from: NLM
pg: r321
has place of publication: England
source: BMJ. 2025-02-13;388():r321.
volume: 388

Detained at the doctor's office: US immigration policy endangers health.
pmid: 39947676
doi: 10.1136/bmj.r304
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Page KR
      type: Person
      first name: Kathleen R
      last name: Page
      member of: Johns Hopkins University School of Medicine, Baltimore, USA.Center for Humanitarian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Center for Public Health and Human Rights, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  slot:
    index: 2
    item: Spiegel PB
      type: Person
      first name: Paul B
      last name: Spiegel
      member of: Center for Humanitarian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  slot:
    index: 3
    item: Cuneo CN
      type: Person
      first name: C Nicholas
      last name: Cuneo
      member of: Johns Hopkins University School of Medicine, Baltimore, USA.Center for Humanitarian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Center for Public Health and Human Rights, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.HEAL Refugee Health and Asylum Collaborative, Baltimore, MD, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:43
e ISSN: 1756-1833
has issn l: 0959-8138
has NLM journal title abbreviation: BMJ
publication name: BMJ (Clinical research ed.)
language: eng
has national library of medicine journal id: 8900488
derived from: NLM
pg: r304
has place of publication: England
source: BMJ. 2025-02-13;388():r304.
volume: 388

Response and remission in asthma with tezepelumab: overlapping concepts informing on type-2 inflammatory-dependent treatment effects.
pmid: 39947688
has PII: 65/2/2402057
doi: 10.1183/13993003.02057-2024
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Mailhot-Larouche S
      type: Person
      first name: Samuel
      last name: Mailhot-Larouche
      member of: Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada.
  slot:
    index: 2
    item: Busby J
      type: Person
      first name: John
      last name: Busby
      member of: Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
  slot:
    index: 3
    item: Couillard S
      type: Person
      first name: Simon
      last name: Couillard
      member of: Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada s.couillard@usherbrooke.ca.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T20:44
e ISSN: 1399-3003
has issn l: 0903-1936
issue: 2
has NLM journal title abbreviation: Eur Respir J
publication name: The European respiratory journal
language: eng
has national library of medicine journal id: 8803460
derived from: NLM
has place of publication: England
source: Eur Respir J. 2025-02;65(2):.
volume: 65

Association of menthol-flavoured cigarette smoking with all-cause and cause-specific mortality risk.
pmid: 39947700
abstract: Menthol-flavoured cigarettes remain unregulated in the USA and in many low- and middle-income countries (LMICs) despite their known impacts on smoking uptake and reduced cessation. Yet, evidence about whether menthol cigarettes are associated with higher disease risks than non-menthol cigarettes is inconclusive, and the industry has used this argument to lobby against regulation.All-cause and cause-specific mortality risk was assessed according to baseline smoking status (current, former and never) and menthol flavour status (menthol and non-menthol) of the cigarette brand smoked for the longest period among 969 349 persons from Cancer Prevention Study-II, a population-based prospective cohort study enrolled in 1982-1983 with mortality follow-up of 6 years.73 486 and 281 680 persons reported menthol brands and non-menthol brands, respectively, among whom 4071 and 20 738 deaths occurred, respectively. Currently smoking cigarettes, whether menthol or non-menthol brands, was associated with highest mortality risks (eg, all causes: about two times higher risk vs never smoking) but quitting substantially reduced risks for both types. Among persons who formerly smoked, menthol versus non-menthol smoking was associated with an elevated mortality risk of 12% from all-causes, 16% from all cardiovascular diseases, 13% from ischaemic heart disease, and 43% from other heart diseases Among individuals currently smoking, there was no difference in mortality risks for menthol versus non-menthol cigarettes except for elevated risk among those smoking≥40 cigarettes per day. Black persons currently smoking menthol versus non-menthol brands had an 88% elevated mortality risk for other heart diseases.Findings of a unique excess mortality risk associated with menthol cigarettes provide additional scientific evidence-apart from their known impacts on initiation and cessation-in support of menthol flavour regulation in the USA and similar policies in LMICs. Public communication efforts mu[cell cut: 2094 characters, first 2000 kept]
rights: © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: tc-2024-059020
doi: 10.1136/tc-2024-059020
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Bandi P
      type: Person
      first name: Priti
      last name: Bandi
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA priti.bandi@cancer.org.
  slot:
    index: 2
    item: Newton C
      type: Person
      first name: Christina
      last name: Newton
      member of: Population Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 3
    item: Xue Z
      type: Person
      first name: Zheng
      last name: Xue
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 4
    item: Thomson B
      type: Person
      first name: Blake
      last name: Thomson
      member of: Stanford University School of Medicine, Stanford, California, USA.
  slot:
    index: 5
    item: Asare S
      type: Person
      first name: Samuel
      last name: Asare
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 6
    item: Patel M
      type: Person
      first name: Minal
      last name: Patel
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 7
    item: Islami F
      type: Person
      first name: Farhad
      last name: Islami
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 8
    item: Nargis N
      type: Person
      first name: Nigar
      last name: Nargis
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 9
    item: Patel AV
      type: Person
      first name: Alpa V
      last name: Patel
      member of: Population Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 10
    item: Jemal A
      type: Person
      first name: Ahmedin
      last name: Jemal
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 11
    item: Westmaas JL
      type: Person
      first name: Johann Lee
      last name: Westmaas
      member of: Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
  slot:
    index: 12
    item: Diver WR
      type: Person
      first name: W Ryan
      last name: Diver
      member of: Population Science, American Cancer Society, Atlanta, Georgia, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:44
e ISSN: 1468-3318
has issn l: 0964-4563
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
has place of publication: England
source: Tob Control. 2025-02-13;():.

Recommended self-report measures for use of menthol, mint and cooling-flavoured nicotine and tobacco products.
pmid: 39947699
has PII: tc-2024-059157
doi: 10.1136/tc-2024-059157
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ozga JE
      type: Person
      first name: Jenny E
      last name: Ozga
      member of: Behavioral Health & Health Policy, Westat Inc, Rockville, Maryland, USA JennyOzga@westat.com.
  slot:
    index: 2
    item: Bold KW
      type: Person
      first name: Krysten W
      last name: Bold
      member of: Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
  slot:
    index: 3
    item: Giovenco DP
      type: Person
      first name: Daniel P
      last name: Giovenco
      member of: Sociomedical Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
  slot:
    index: 4
    item: Villanti AC
      type: Person
      first name: Andrea C
      last name: Villanti
      member of: Rutgers Institute for Nicotine & Tobacco Studies, Rutgers School of Public Health, New Brunswick, New Jersey, USA.
  slot:
    index: 5
    item: Unger JB
      type: Person
      first name: Jennifer B
      last name: Unger
      member of: Population and Public Health Sciences, University of Southern California Kick School of Medicine, Los Angeles, California, USA.
  slot:
    index: 6
    item: Leventhal A
      type: Person
      first name: Adam
      last name: Leventhal
      member of: Population and Public Health Sciences, University of Southern California Kick School of Medicine, Los Angeles, California, USA.
  slot:
    index: 7
    item: Stanton C
      type: Person
      first name: Cassandra
      last name: Stanton
      member of: Behavioral Health & Health Policy, Westat Inc, Rockville, Maryland, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:44
e ISSN: 1468-3318
has issn l: 0964-4563
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
has place of publication: England
source: Tob Control. 2025-02-13;():.

Subdural haematoma of arterial origin: a rare presentation of giant cell arteritis.
pmid: 39947722
has PII: 18/2/e262773
doi: 10.1136/bcr-2024-262773
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Forrest C
      type: Person
      first name: Clara
      last name: Forrest
      member of: Department of Rheumatology, Cork University Hospital, Cork, Ireland claraforrest1@hotmail.com.
  slot:
    index: 2
    item: Tio SW
      type: Person
      first name: Sherdya Worthy
      last name: Tio
      member of: Department of Rheumatology, Cork University Hospital, Cork, Ireland.
  slot:
    index: 3
    item: MacMullen P
      type: Person
      first name: Paul
      last name: MacMullen
      member of: Department of Rheumatology, Cork University Hospital, Cork, Ireland.
  slot:
    index: 4
    item: Murphy G
      type: Person
      first name: Grainne
      last name: Murphy
      member of: Department of Rheumatology, Cork University Hospital, Cork, Ireland.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 2
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2025-02-13;18(2):.
volume: 18

Congenital generalised lipodystrophy type 2.
pmid: 39947733
has PII: 18/2/e264477
doi: 10.1136/bcr-2024-264477
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Gowda VK
      type: Person
      first name: Vykuntaraju K
      last name: Gowda
      member of: Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, India drknvraju08@gmail.com.
  slot:
    index: 2
    item: Roy A
      type: Person
      first name: Amaresh
      last name: Roy
      member of: Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, India.
  slot:
    index: 3
    item: Srinivasan VM
      type: Person
      first name: Varunvenkat M
      last name: Srinivasan
      member of: Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, India.
  slot:
    index: 4
    item: Kumar P
      type: Person
      first name: Prahalad
      last name: Kumar
      member of: Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, India.
  slot:
    index: 5
    item: Challa VSR
      type: Person
      first name: Viveka Santhosh Reddy
      last name: Challa
      member of: Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, India.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 2
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2025-02-13;18(2):.
volume: 18

Familial non-syndromic fistula labii inferioris.
pmid: 39947732
has PII: 18/2/e263688
doi: 10.1136/bcr-2024-263688
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Mutalik SD
      type: Person
      first name: Sharad D
      last name: Mutalik
      member of: Department of Dermatology, Venereology and Leprosy, Maharashtra Medical Foundation Joshi Hospital, Pune, Maharashtra, India.
  slot:
    index: 2
    item: Hegde SS
      type: Person
      first name: Shibhani Sudheer
      last name: Hegde
      member of: Department of Dermatology, Venereology and Leprosy, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, India shibhani.hegde@bharatividyapeeth.edu.
  slot:
    index: 3
    item: Dilkush R
      type: Person
      first name: Raisah
      last name: Dilkush
      member of: Nitte Mahalinga Adyanthaya Memorial Institute of Technology, Mangalore, India.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T20:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 2
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2025-02-13;18(2):.
volume: 18

Long-term outcome in a cohort of 36 patients with sacral dural arteriovenous fistulae after endovascular embolisation or microsurgery.
pmid: 39947741
abstract: Sacral dural arteriovenous fistula (SDAVF) is a rare spinal vascular malformation and often misdiagnosed or even mistreated. This study delved into the clinical characteristics, vascular architecture and treatment results of SDAVF, with the goal of enhancing upcoming diagnostic and therapeutic methodologies.From March 2014 to March 2022, consecutive patients with SDAVF were retrospectively analysed. The data on demographics, symptom resolution, angioarchitectural features and postoperative course were studied. Spinal cord function was evaluated by modified Aminoff-Logue scale.A total of 36 patients with 36 SDAVFs were enrolled, 12 of whom were misdiagnosed on their initial visit. The SDAVFs were located at S1 in 24 (66.7%), S2 in 10 (27.8%) and S3 in 2 (5.6%) cases, respectively. The primary feeding arteries included lateral sacral artery (LSA) of internal iliac artery (31/36, 86.1%), the branches of external iliac artery (2/36, 5.6%) and median artery (3/36, 8.3%), most of which are straight. Venae terminalisis is the sole drainage vein, flowing back into perimedullary venous network. Endovascular embolisation is the main therapy method for 30 cases, while the other 6 cases were treated with microsurgical fistulectomy. MRI tests showed that the abnormal vascular signals around the medulla disappeared, and the spinal cord oedema was alleviated in the majority of cases (32/36, 88.9%). Six patients, who all were treated by endovascular embolisation at first time, had residual or recurrent and two of them were performed by microsurgical fistulectomy again. All patients by microsurgical fistulectomy had no residual or recurrent during follow-up. According to the spinal cord functional assessment, the Aminoff-Logue score was significantly decreased (Z=-3.449, p=0.001) postoperatively.The misdiagnosis rate of SDAVF is very high. The most feeding artery of SDAVF came from the LSA, which was thicker and more straight, making it easier for microcatheters to reach the fistula[cell cut: 2128 characters, first 2000 kept]
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: svn-2024-003463
doi: 10.1136/svn-2024-003463
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Duan Y
      type: Person
      first name: Yu
      last name: Duan
      member of: Department of Neurosurgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
  slot:
    index: 2
    item: Qin X
      type: Person
      first name: Xuanfeng
      last name: Qin
      member of: Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China.
  slot:
    index: 3
    item: Chen Q
      type: Person
      first name: Qinyi
      last name: Chen
      member of: Law School, Shantou University, Shantou, China.
  slot:
    index: 4
    item: Xu B
      type: Person
      first name: Binbin
      last name: Xu
      member of: Department of neurosurgery, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  slot:
    index: 5
    item: An Q
      type: Person
      first name: Qinzhu
      last name: An
      member of: Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China.
  slot:
    index: 6
    item: Liao Y
      type: Person
      first name: Yujun
      last name: Liao
      member of: Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China.
  slot:
    index: 7
    item: Hu Y
      type: Person
      first name: Yuanyuan
      last name: Hu
      member of: Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China.
  slot:
    index: 8
    item: Chen G
      type: Person
      first name: Gong
      last name: Chen
      member of: Department of Neurosurgery, Huashan Hospital Fudan University, Shanghai, China gong_chen@fudan.edu.cn.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:02
e ISSN: 2059-8696
has issn l: 2059-8688
has NLM journal title abbreviation: Stroke Vasc Neurol
publication name: Stroke and vascular neurology
language: eng
has national library of medicine journal id: 101689996
derived from: NLM
has place of publication: England
source: Stroke Vasc Neurol. 2025-02-13;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39947757
pmid: 39947757
has PII: S1259-4792(24)00148-2
doi: 10.1016/j.spp.2024.10.003
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Elezaar A
      type: Person
      first name: Amelle
      last name: Elezaar
      member of: Pouponnière - Association Pluriels, 1760 chemin de la Décelle, 26130 Saint-Paul-Trois-Châteaux, France. Electronic address: amelle.z@hotmail.fr.
created: 2025-2-14T00:23
date last updated: 2025-02-13
created: 2025-2-13T21:12
ISSN: 1259-4792
has issn l: 1259-4792
issue: 342
has NLM journal title abbreviation: Soins Pediatr Pueric
publication name: Soins. Pediatrie, puericulture
language: fre
has national library of medicine journal id: 9604503
derived from: NLM
pg: 1
has place of publication: France
source: Soins Pediatr Pueric. ;46(342):1.
volume: 46

http://rdf.ncbi.nlm.nih.gov/pubmed/39947766
pmid: 39947766
has PII: S1259-4792(24)00149-4
doi: 10.1016/j.spp.2024.10.004
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Hagbarth Legrée I
      type: Person
      first name: Isabelle
      last name: Hagbarth Legrée
      member of: Service de psychiatrie de l'enfant et de l'adolescent, Groupe hospitalier Pitié-Salpétrière, AP-HP, Sorbonne université, 47-83 boulevard de l'Hôpital, 75013 Paris, France. Electronic address: isabellehagbarth@yahoo.fr.
created: 2025-2-14T00:24
date last updated: 2025-02-13
created: 2025-2-13T21:12
ISSN: 1259-4792
has issn l: 1259-4792
issue: 342
has NLM journal title abbreviation: Soins Pediatr Pueric
publication name: Soins. Pediatrie, puericulture
language: fre
has national library of medicine journal id: 9604503
derived from: NLM
starting page: 7
ending page: 38
has place of publication: France
source: Soins Pediatr Pueric. ;46(342):7-38.
volume: 46

ExTech 2023: Cutting-edge research towards sustainability and microextraction.
pmid: 39947787
has PII: S0003-2670(24)01388-6
doi: 10.1016/j.aca.2024.343587
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pino V
      type: Person
      first name: Verónica
      last name: Pino
      member of: Laboratorio de Materiales para Análisis Químico (MAT4LL), Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), 38206 San Cristóbal de La Laguna, Spain; Unidad de Investigación de Bioanalítica y Medio Ambiente, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSP), ULL, 38206 San Cristóbal de La Laguna, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (Ciberinfec), Instituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address: veropino@ull.edu.es.
  slot:
    index: 2
    item: Hernández-Borges J
      type: Person
      first name: Javier
      last name: Hernández-Borges
      member of: Unidad de Investigación de Bioanalítica y Medio Ambiente, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSP), ULL, 38206 San Cristóbal de La Laguna, Spain; Grupo de Química Analítica Aplicada (AChem Group), Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), 38206 San Cristóbal de La Laguna, Spain. Electronic address: jhborges@ull.edu.es.
  slot:
    index: 3
    item: Trujillo-Rodríguez MJ
      type: Person
      first name: María J
      last name: Trujillo-Rodríguez
      member of: Laboratorio de Materiales para Análisis Químico (MAT4LL), Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), 38206 San Cristóbal de La Laguna, Spain; Unidad de Investigación de Bioanalítica y Medio Ambiente, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSP), ULL, 38206 San Cristóbal de La Laguna, Spain.
  slot:
    index: 4
    item: González-Sálamo J
      type: Person
      first name: Javier
      last name: González-Sálamo
      member of: Unidad de Investigación de Bioanalítica y Medio Ambiente, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSP), ULL, 38206 San Cristóbal de La Laguna, Spain; Grupo de Química Analítica Aplicada (AChem Group), Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), 38206 San Cristóbal de La Laguna, Spain.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-03-15
dp: 2025 Mar 15
created: 2025-2-13T21:13
e ISSN: 1873-4324
has issn l: 0003-2670
has NLM journal title abbreviation: Anal Chim Acta
publication name: Analytica chimica acta
language: eng
has national library of medicine journal id: 0370534
derived from: NLM
pg: 343587
has place of publication: Netherlands
source: Anal Chim Acta. 2025-03-15;1343():343587.
volume: 1343

Feature selection and extraction strategies for non-targeted analysis using GC-MS and GC-IMS: A tutorial.
pmid: 39947788
abstract: Gas chromatography-mass spectrometry (GC-MS) and gas chromatography-ion mobility spectrometry (GC-IMS) are two powerful separation and detection techniques for non-targeted analysis (NTA) of volatile compounds. Combined with multivariate chemometric analysis, they have been successfully applied to several areas in chemical, environmental, food, flavor and medical sciences. The recorded raw GC-MS and GC-IMS data include high numbers of variables (features) due to the high scan speeds of the instrument. Additionally, NTA approaches, by design, record more data than required. Therefore, reducing the number of features is a key step in any chemometric pipeline to reduce overfitting, overlong training times and model complexity. There are various feature engineering strategies in the literature for GC-MS and GC-IMS data which make it more difficult for users to decide which method is more appropriate for their cases. Therefore, the objective of this tutorial paper is presenting the idea of feature selection and feature extraction techniques in GC-MS and GC-IMS data and then, comparing the performance of different strategies in NTA approaches. Additionally, the effect of feature selection and extraction strategies in pattern recognition problems will be discussed with some informative examples. We will demonstrate workflows based on available tools that can be used to ensure that every researcher can follow our tutorial.
rights: Copyright © 2025 Elsevier B.V. All rights reserved.
has PII: S0003-2670(25)00029-7
doi: 10.1016/j.aca.2025.343635
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Parastar H
      type: Person
      first name: Hadi
      last name: Parastar
      member of: Department of Chemistry, Sharif University of Technology, Tehran, Iran. Electronic address: h.parastar@sharif.edu.
  slot:
    index: 2
    item: Weller P
      type: Person
      first name: Philipp
      last name: Weller
      member of: Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, 68163, Mannheim, Germany. Electronic address: p.weller@hs-mannheim.de.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-03-15
dp: 2025 Mar 15
created: 2025-2-13T21:13
e ISSN: 1873-4324
has issn l: 0003-2670
has NLM journal title abbreviation: Anal Chim Acta
publication name: Analytica chimica acta
language: eng
has national library of medicine journal id: 0370534
derived from: NLM
pg: 343635
has place of publication: Netherlands
source: Anal Chim Acta. 2025-03-15;1343():343635.
volume: 1343

Graphene oxide functionalized with hydrophilic ionic liquid as stir bar coating: Sorptive extraction of selected triazines in grape juice samples.
pmid: 39947798
abstract: Sample preparation is essential for reducing matrix compound effects, increasing analytical method efficiency, and enhancing the detection of target compounds. Miniaturized techniques are preferred over conventional methods, due to their alignment with green analytical chemistry principles, reducing waste and offering comparable efficiency. The effectiveness of extraction techniques based on the use of sorbents depends on sorbent-analyte interactions, driving the search for more selective and versatile materials. Graphene oxide is noted for its high surface area, conjugated structure, and potential for functionalization, improving its adsorption capacity and modifying its polarity.In this work, novel sorbents were prepared by functionalizing graphene oxide with two hydrophilic ionic liquids of different structures and evaluated for their extraction capacity for five triazine herbicides. The best hybrid sorbent was used as a coating for homemade stirring bars and applied in the sorptive extraction of five triazines in grape juice samples, combined with determination by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After optimizing the extraction conditions, the method showed a linear range of 1-50 ng mL-1 for ametryn, atrazine, simazine, and prometryn, and 1-100 ng mL-1 for propazine (r2 ≥ 0.9955). The limits of quantification in grape juice samples ranged from 0.0015 to 0.0500 ng mL-1 with precision as relative standard deviation (RSD) values less than 15 % and recoveries ranging from 45.3 % to 98.6 %.The reported work demonstrates that functionalized graphene oxide with hydrophilic ionic liquids can be successfully used in stir bar sorptive extraction (SBSE) to enhance the efficiency of the method and the sorption of triazines. Additionally, the method uses a low volume of organic solvent, and the fabricated extraction device is low-cost, employs a small amount of sorbent, and is reusable, increasing the analytical frequency f[cell cut: 2062 characters, first 2000 kept]
rights: Copyright © 2025 Elsevier B.V. All rights reserved.
has PII: S0003-2670(25)00085-6
doi: 10.1016/j.aca.2025.343691
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Cardoso AT
      type: Person
      first name: Alessandra Timóteo
      last name: Cardoso
      member of: Laboratory of Chromatography, São Carlos Institute of Chemistry, Universidade de São Paulo, 13566-590, São Carlos, Brazil.
  slot:
    index: 2
    item: Lanças FM
      type: Person
      first name: Fernando Mauro
      last name: Lanças
      member of: Laboratory of Chromatography, São Carlos Institute of Chemistry, Universidade de São Paulo, 13566-590, São Carlos, Brazil. Electronic address: flancas@iqsc.usp.br.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-03-15
dp: 2025 Mar 15
created: 2025-2-13T21:13
e ISSN: 1873-4324
has issn l: 0003-2670
has NLM journal title abbreviation: Anal Chim Acta
publication name: Analytica chimica acta
language: eng
has national library of medicine journal id: 0370534
derived from: NLM
pg: 343691
has place of publication: Netherlands
source: Anal Chim Acta. 2025-03-15;1343():343691.
volume: 1343

Call for applicants for the position of Editor-in-Chief of the Annals of Physical and Rehabilitation Medicine.
pmid: 39947812
has PII: S1877-0657(25)00013-2
doi: 10.1016/j.rehab.2025.101948
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Pérrenou D
      type: Person
      first name: Dominic
      last name: Pérrenou
      member of: Univ. Grenoble Alpes, UMR CNRS 5105 Neuropsychology and Neuro Cognition, CHU Grenoble Alpes, Dept of Neuro Rehabilitation South Hospital, Cs 10217 - 38043 Grenoble cedex 9, France. Electronic address: dperennou@chu-grenoble.fr.
  slot:
    index: 2
    item: Rannou F
      type: Person
      first name: François
      last name: Rannou
      member of: AP-HP.Centre-Université Paris Cité, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T21:14
e ISSN: 1877-0665
has issn l: 1877-0657
issue: 1
has NLM journal title abbreviation: Ann Phys Rehabil Med
publication name: Annals of physical and rehabilitation medicine
language: eng
has national library of medicine journal id: 101502773
derived from: NLM
pg: 101948
has place of publication: Netherlands
source: Ann Phys Rehabil Med. 2025-02;68(1):101948.
volume: 68

Rebranding at the Intersections: A New Look For Our Field.
pmid: 39947810
has PII: S1071-9164(25)00023-5
doi: 10.1016/j.cardfail.2025.01.007
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Lala A
      type: Person
      first name: Anuradha
      last name: Lala
      member of: Mount Sinai Fuster Heart Hospital and Department of Population Health Science and Policy, Mount Sinai, New York, NY, USA. Electronic address: Anu.lala@mountsinai.org.
  slot:
    index: 2
    item: Mentz RJ
      type: Person
      first name: Robert J
      last name: Mentz
      member of: Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T21:13
e ISSN: 1532-8414
has issn l: 1071-9164
issue: 2
has NLM journal title abbreviation: J Card Fail
publication name: Journal of cardiac failure
language: eng
has national library of medicine journal id: 9442138
derived from: NLM
pg: 353
has place of publication: United States
source: J Card Fail. 2025-02;31(2):353.
volume: 31

Our thanks to persons who review papers for the Annals of Physical and Rehabilitation Medicine.
pmid: 39947813
has PII: S1877-0657(25)00015-6
doi: 10.1016/j.rehab.2025.101950
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Pérennou D
      type: Person
      first name: Dominic
      last name: Pérennou
      member of: Editor in Chief of the Annals of Physical and Rehabilitation Medicine.; Laboratoire Psychology and Neurocognition, University Grenoble-Alpes; and service de Rééducation Neurologique, Institut de Rééducation Hôpital sud -CHU Grenoble-Alpes, Av de Kimberley 38400 Echirolles, France. Electronic address: dperennou@chu-grenoble.fr.
  slot:
    index: 2
    item: Burger H
      type: Person
      first name: Helena
      last name: Burger
      member of: University Rehabilitation Institute Republic of Slovenia - Soca, Ljubljana, Slovenia.
  slot:
    index: 3
    item: Paik NJ
      type: Person
      first name: Nam-Jong
      last name: Paik
      member of: Seoul National University Hospital Department of Rehabilitation Medicine, Seoul, Republic of Korea.
  slot:
    index: 4
    item: Brochard S
      type: Person
      first name: Sylvain
      last name: Brochard
      member of: Université de Bretagne Occidentale, Centre Hospitalier Universitaire de Brest, Laboratoire du Traitement de l'information Médicale, LaTIM, INSERM UMR 1101 Brest, France.
  slot:
    index: 5
    item: Coudeyre E
      type: Person
      first name: Emmanuel
      last name: Coudeyre
      member of: Service de Médecine Physique et de Réadaptation, CHU Clermont-Ferrand, Hôpital Louise Michel, Route de Chateaugay, 63 118 Cébazat, Faculté de Médecine et des professions paramédicales -Equipe ASMS, INRAE, Université Clermont Auvergne, France.
  slot:
    index: 6
    item: Denys P
      type: Person
      first name: Pierre
      last name: Denys
      member of: Neuro Urology and Andrology Unit, Department of PMR, Hôpital Raymond Poincaré APHP; 104 bd Raymond Poincaré, 92380 Garches, university of Versailles Saint Quentin, UMR 1179 Inserm.
  slot:
    index: 7
    item: Azouvi P
      type: Person
      first name: Philippe
      last name: Azouvi
      member of: Hospital Raymond-Poincare Department of Rehabilitation Medicine and Pediatric Readaptation, Garches, France.
  slot:
    index: 8
    item: Nguyen C
      type: Person
      first name: Christelle
      last name: Nguyen
      member of: Université Paris Cité, Faculté de Santé, UFR de Médecine, 75006 Paris, France. AP-HP. Centre-Université Paris Cité, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpital Cochin, 75014 Paris, France - INSERM UMR-S 1124, Toxicité Environnementale, Cibles Thérapeutiques, Signalisation Cellulaire et Biomarqueurs (T3S), Campus Saint-Germain-des-Prés, 75006 Paris, France.
  slot:
    index: 9
    item: Nadeau S
      type: Person
      first name: Sylvie
      last name: Nadeau
      member of: École de Réadaptation, Faculté de médecine, Université de Montréal. Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain (CRIR). Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM). Centre intégré universitaire de santé et de services sociaux du Centre-Sud del'Ile de Montréal.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T21:14
e ISSN: 1877-0665
has issn l: 1877-0657
issue: 1
has NLM journal title abbreviation: Ann Phys Rehabil Med
publication name: Annals of physical and rehabilitation medicine
language: eng
has national library of medicine journal id: 101502773
derived from: NLM
pg: 101950
has place of publication: Netherlands
source: Ann Phys Rehabil Med. 2025-02;68(1):101950.
volume: 68

Topiramate-induced acute eosinophilic pneumonia.
pmid: 39947836
has PII: dtb.2025.261220rep
doi: 10.1136/dtb.2025.261220rep
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Tyagi R
      type: Person
      first name: Rahul
      last name: Tyagi
      member of: Respiratory Medicine, AICTS, Pune, India rahultyagi4960@gmail.com.
  slot:
    index: 2
    item: Aggarwal M
      type: Person
      first name: Monika
      last name: Aggarwal
      member of: AICTS, Pune, India.
  slot:
    index: 3
    item: Suyal U
      type: Person
      first name: Utkarsh
      last name: Suyal
      member of: AFMC Campus, Pune, Maharashtra, India.
  slot:
    index: 4
    item: Pandey I
      type: Person
      first name: Indramani
      last name: Pandey
      member of: AFMC Campus, Pune, Maharashtra, India.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:15
e ISSN: 1755-5248
has issn l: 0012-6543
has NLM journal title abbreviation: Drug Ther Bull
publication name: Drug and therapeutics bulletin
language: eng
has national library of medicine journal id: 0112037
derived from: NLM
has place of publication: England
source: Drug Ther Bull. 2025-02-13;():.

On the (Im)possible Interplays Between Natural and Magnetic Optical Activity in Chiral Samples.
pmid: 39947833
abstract: The simultaneous presence of natural and magnetic optical activity in chiral samples is a very interesting occurrence, but it may lead to incorrect data interpretation if appropriate care is not taken. Moving from simple but general principles, here we show which effects are possible and which are not in such cases.
rights: © 2025 Wiley Periodicals LLC.
doi: 10.1002/chir.70024
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Zinna F
      type: Person
      first name: Francesco
      last name: Zinna
      member of: Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Pisa, Italy.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T21:15
e ISSN: 1520-636X
has issn l: 0899-0042
issue: 2
has NLM journal title abbreviation: Chirality
publication name: Chirality
language: eng
has national library of medicine journal id: 8914261
derived from: NLM
pg: e70024
has place of publication: United States
source: Chirality. 2025-02;37(2):e70024.
volume: 37

Symbiotic nitrogen-fixing rhizobia as a potential source of nitrous oxide emissions.
pmid: 39947842
has PII: S0325-7541(25)00022-7
doi: 10.1016/j.ram.2025.01.003
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Lodeiro AR
      type: Person
      first name: Aníbal R
      last name: Lodeiro
      member of: Instituto de Biotecnología y Biología Molecular (IBBM), CCT-La Plata, CONICET y Facultad de Ciencias Exactas, UNLP, La Plata, Argentina; Curso de Genética, Departamento de Ciencias Biológicas, Facultad de Ciencias Agrarias y Forestales, UNLP, La Plata, Argentina. Electronic address: lodeiro@biol.unlp.edu.ar.
created: 2025-2-14T00:23
date last updated: 2025-02-13
created: 2025-2-13T21:16
ISSN: 0325-7541
has issn l: 0325-7541
issue: 1
has NLM journal title abbreviation: Rev Argent Microbiol
publication name: Revista Argentina de microbiologia
language: eng
has national library of medicine journal id: 8002834
derived from: NLM
starting page: 1
ending page: 2
has place of publication: Argentina
source: Rev Argent Microbiol. ;57(1):1-2.
volume: 57

Chronic diarrhoea, weight loss and a positive anti-tissue transglutaminase antibody: a case report of olmesartan-induced enteropathy.
pmid: 39947837
has PII: dtb.2025.255407rep
doi: 10.1136/dtb.2025.255407rep
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sheppard R
      type: Person
      first name: Rachel
      last name: Sheppard
      member of: NHS Lothian, Edinburgh, UK.
  slot:
    index: 2
    item: Evanson B
      type: Person
      first name: Benjamin
      last name: Evanson
      member of: NHS Lothian, Edinburgh, UK ben.evanson@nhs.scot.
  slot:
    index: 3
    item: Campbell I
      type: Person
      first name: Iona
      last name: Campbell
      member of: NHS Lothian, Edinburgh, UK.
  slot:
    index: 4
    item: Shand A
      type: Person
      first name: Alan
      last name: Shand
      member of: Gastroenterology Unit, NHS Lothian, Edinburgh, UK.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:15
e ISSN: 1755-5248
has issn l: 0012-6543
has NLM journal title abbreviation: Drug Ther Bull
publication name: Drug and therapeutics bulletin
language: eng
has national library of medicine journal id: 0112037
derived from: NLM
has place of publication: England
source: Drug Ther Bull. 2025-02-13;():.

Airway consequences of alendronic acid aspiration.
pmid: 39947839
has PII: dtb.2025.260930rep
doi: 10.1136/dtb.2025.260930rep
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lonsdale H
      type: Person
      first name: Henry
      last name: Lonsdale
      member of: ENT Directorate, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK hplonsdale@doctors.org.uk.
  slot:
    index: 2
    item: Sawant R
      type: Person
      first name: Rupali
      last name: Sawant
      member of: ENT Directorate, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  slot:
    index: 3
    item: Kinshuck A
      type: Person
      first name: Andrew
      last name: Kinshuck
      member of: ENT Directorate, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  slot:
    index: 4
    item: Fleming J
      type: Person
      first name: Jason
      last name: Fleming
      member of: ENT Directorate, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.University of Liverpool, Liverpool, UK.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:15
e ISSN: 1755-5248
has issn l: 0012-6543
has NLM journal title abbreviation: Drug Ther Bull
publication name: Drug and therapeutics bulletin
language: eng
has national library of medicine journal id: 0112037
derived from: NLM
has place of publication: England
source: Drug Ther Bull. 2025-02-13;():.

Drug-induced liver injury secondary to tamoxifen.
pmid: 39947838
has PII: dtb.2025.260098rep
doi: 10.1136/dtb.2025.260098rep
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Subhaharan D
      type: Person
      first name: Deloshaan
      last name: Subhaharan
      member of: Department of Hepatology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia natalie.commins@gmail.com deloshaan.subhaharan@health.qld.gov.au.
  slot:
    index: 2
    item: Murphy G
      type: Person
      first name: Grace
      last name: Murphy
      member of: Department of Medical Oncology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.
  slot:
    index: 3
    item: Commins N
      type: Person
      first name: Natalie
      last name: Commins
      member of: Department of Hepatology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia natalie.commins@gmail.com deloshaan.subhaharan@health.qld.gov.au.
  slot:
    index: 4
    item: Azer M
      type: Person
      first name: Mary
      last name: Azer
      member of: Department of Medical Oncology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:15
e ISSN: 1755-5248
has issn l: 0012-6543
has NLM journal title abbreviation: Drug Ther Bull
publication name: Drug and therapeutics bulletin
language: eng
has national library of medicine journal id: 0112037
derived from: NLM
has place of publication: England
source: Drug Ther Bull. 2025-02-13;():.

Development and multicenter validation of machine learning models for predicting postoperative pulmonary complications after neurosurgery.
pmid: 39947880
abstract: Postoperative pulmonary complications (PPCs) are major adverse events in neurosurgical patients. This study aimed to develop and validate machine learning models predicting PPCs after neurosurgery.PPCs were defined according to the European Perioperative Clinical Outcome standards as occurring within 7 postoperative days. Data of cases meeting inclusion/exclusion criteria were extracted from the anesthesia information management system to create three datasets: The development (data of Huashan Hospital, Fudan University from 2018 to 2020), temporal validation (data of Huashan Hospital, Fudan University in 2021) and external validation (data of other three hospitals in 2023) datasets. Machine learning models of six algorithms were trained using either 35 retrievable and plausible features or the 11 features selected by Lasso regression. Temporal validation was conducted for all models and the 11-feature models were also externally validated. Independent risk factors were identified and feature importance in top models was analyzed.PPCs occurred in 712 of 7533 (9.5%), 258 of 2824 (9.1%), and 207 of 2300 (9.0%) patients in the development, temporal validation and external validation datasets, respectively. During cross-validation training, all models except Bayes demonstrated good discrimination with an area under the receiver operating characteristic curve (AUC) of 0.84. In temporal validation of full-feature models, deep neural network (DNN) performed the best with an AUC of 0.835 (95% confidence interval [CI]: 0.805-0.858) and a Brier score of 0.069, followed by logistic regression (LR), random forest and XGBoost. The 11-feature models performed comparable to full-feature models with very close but statistically lower AUCs, with the top models of DNN and LR in temporal and external validations. An 11-feature nomogram was drawn based on the LR algorithm and it outperformed the minimally modified Assess respiratory RIsk in Surgical patients in CATalonia (ARISCAT) and [cell cut: 2744 characters, first 2000 kept]
rights: Copyright © 2025 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.
has PII: 00029330-990000000-01426
doi: 10.1097/CM9.0000000000003433
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Xu M
      type: Person
      first name: Ming
      last name: Xu
      member of: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
  slot:
    index: 2
    item: Zhu W
      type: Person
      first name: Wenhao
      last name: Zhu
      member of: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
  slot:
    index: 3
    item: Hou S
      type: Person
      first name: Siyu
      last name: Hou
      member of: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
  slot:
    index: 4
    item: Xu H
      type: Person
      first name: Hongzhi
      last name: Xu
      member of: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
  slot:
    index: 5
    item: Xia J
      type: Person
      first name: Jingwen
      last name: Xia
      member of: Department of Respiratory Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
  slot:
    index: 6
    item: Lin L
      type: Person
      first name: Liyu
      last name: Lin
      member of: State Key Laboratory of Integrated Chips and Systems, Fudan University, Shanghai 201203, China.
  slot:
    index: 7
    item: Fu H
      type: Person
      first name: Hao
      last name: Fu
      member of: Department of Control Science and Engineering, College of Electronic and Information Engineering, Tongji University, Shanghai 201804, China.
  slot:
    index: 8
    item: You M
      type: Person
      first name: Mingyu
      last name: You
      member of: Department of Control Science and Engineering, College of Electronic and Information Engineering, Tongji University, Shanghai 201804, China.
  slot:
    index: 9
    item: Wang J
      type: Person
      first name: Jiafeng
      last name: Wang
      member of: Department of Anesthesiology, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
  slot:
    index: 10
    item: Xie Z
      type: Person
      first name: Zhi
      last name: Xie
      member of: Department of Anesthesiology, Shanghai Neuromedical Center, Shanghai 200331, China.
  slot:
    index: 11
    item: Wen X
      type: Person
      first name: Xiaohong
      last name: Wen
      member of: Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
  slot:
    index: 12
    item: Wang Y
      type: Person
      first name: Yingwei
      last name: Wang
      member of: Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:23
e ISSN: 2542-5641
has issn l: 0366-6999
has NLM journal title abbreviation: Chin Med J (Engl)
publication name: Chinese medical journal
language: eng
has national library of medicine journal id: 7513795
derived from: NLM
has place of publication: China
source: Chin Med J (Engl). 2025-02-13;():.

Practitioner experiences of developing and implementing two UK ED-based hospital violence intervention programmes: a process evaluation.
pmid: 39947874
abstract: EDs can address modifiable risks of patients attending due to violence. Hospital-based violence intervention programmes (HVIPs) can reduce patients' exposure to violence but can place additional burdens on staff. We explored practitioners' views on two nurse-led HVIPs' design and delivery, response to patient need, engagement with ED health professionals, adaptation to local context and analysed documents relevant to these objectives.This was a qualitative process evaluation, from January to September 2023, of two nurse-led HVIPs implemented in a major trauma centre and a large urban hospital in the UK. Interview participants (N=49) were involved with the commission and implementation of the HVIPs, or worked within the broader violence-prevention ecology. We gathered perspectives on intervention implementation and undertook documentary analysis on local and national policies, and guidance relating to HVIPs development, implementation and delivery (N=46). Documentary data were subject to thematic and content analyses, interview data to thematic analysis.HVIPs were developed in response to a perceived under-provision of services for patients attending EDs due to violence. The HVIP nurses had access to clinical records facilitating the identification of eligible patients. They provided patient-centred care, addressing needs through referrals into health and community-based services. Over 60% of eligible patients engaged. The nurses were seen as credible champions working towards a minimally burdensome service that supported and trained ED staff. Embedding HVIPs into usual care took time and was limited by the perceived short-term nature of the intervention.The implementation of nurse-led HVIPs enables access to clinical records, facilitating patient engagement, and can provide an additional service aligned to usual emergency care, supporting both patients and ED staff.The protocol was pre-registered (ISRCTN 15286575; March 13, 2023) and published before data collection[cell cut: 2014 characters, first 2000 kept]
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: emermed-2024-214333
doi: 10.1136/emermed-2024-214333
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Moore S
      type: Person
      first name: Simon
      last name: Moore
      member of: School of Dentistry, Cardiff University, Cardiff, UK mooresc2@cardiff.ac.uk.Security, Crime & Intelligence Innovation Institute, Cardiff University, Cardiff, UK.
  slot:
    index: 2
    item: Van Godwin J
      type: Person
      first name: Jordan
      last name: Van Godwin
      member of: DECIPHer, Cardiff University, Cardiff, UK.
  slot:
    index: 3
    item: Moore G
      type: Person
      first name: Graham
      last name: Moore
      member of: DECIPHer, Cardiff University, Cardiff, UK.Cardiff University, Cardiff, UK.
  slot:
    index: 4
    item: Hamilton M
      type: Person
      first name: Megan
      last name: Hamilton
      member of: School of Dentistry, Cardiff University, Cardiff, UK.
  slot:
    index: 5
    item: O'Reilly D
      type: Person
      first name: David
      last name: O'Reilly
      member of: Cardiff Liver Unit, Cardiff and Vale NHS Trust, Cardiff, UK.Academic Department of Military Surgery and Trauma, Defence Medical Services, Birmingham, UK.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:23
e ISSN: 1472-0213
has issn l: 1472-0205
has NLM journal title abbreviation: Emerg Med J
publication name: Emergency medicine journal : EMJ
language: eng
has national library of medicine journal id: 100963089
derived from: NLM
has place of publication: England
source: Emerg Med J. 2025-02-13;():.

Improving stroke pathway efficiency: outcomes of a quality improvement collaborative across a national stroke network.
pmid: 39947892
abstract: Timely endovascular thrombectomy (EVT) is crucial for improving outcomes in acute ischemic stroke (AIS). This study evaluated the effectiveness of a national quality improvement collaborative (QIC) in reducing process times for potential EVT candidates across a national stroke network.A pre-post intervention design using a modified Breakthrough Series approach was implemented across 24 hospitals. Multidisciplinary teams participated in monthly learning sessions and action periods focused on reducing 'Door to Decision' (time from hospital arrival to EVT decision) to under 30 min. Mixed-effects linear models and mixed-effects ANOVA were used to analyse the impact of the QI program on Door to Decision and Door to CT times, comparing intervention and control cohorts.The QI program significantly reduced Door to Decision time in the intervention cohort by 15.9% (p<0.001) from a mean of 92.8 min to 78.9 min. Door to CT time also decreased by 15.6% (p<0.001). No significant changes were observed in the control cohort. Mixed-ANOVA revealed a significant interaction effect for both Door to Decision (p<0.004) and Door to CT (p<0.04), indicating that the QI program impacted these times as compared with the control group. The QIC effectively improved the efficiency of stroke care pathways across a national stroke network. This effect was sustained across the network and over time. This success was facilitated by a bottom-up approach, fostering collaboration and shared learning within and across hospitals.This study demonstrates the effectiveness of a collaborative, network-wide QI program in reducing critical process times for AIS patients. Continued efforts to sustain these improvements and optimize stroke care pathways are warranted.
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: jnis-2024-022771
doi: 10.1136/jnis-2024-022771
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Walsh R
      type: Person
      first name: Roisin
      last name: Walsh
      member of: Royal College of Surgeons in Ireland, Dublin, Ireland.
  slot:
    index: 2
    item: Nowlan N
      type: Person
      first name: Naomi
      last name: Nowlan
      member of: Royal College of Surgeons in Ireland, Dublin, Ireland naominowlan@rcsi.ie.Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 3
    item: Griffin E
      type: Person
      first name: Emma
      last name: Griffin
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 4
    item: McElroy S
      type: Person
      first name: Sinead
      last name: McElroy
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 5
    item: O'Grada C
      type: Person
      first name: Colm
      last name: O'Grada
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 6
    item: Power S
      type: Person
      first name: Sarah
      last name: Power
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 7
    item: O'Hare A
      type: Person
      first name: Alan
      last name: O'Hare
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 8
    item: Crockett M
      type: Person
      first name: Matthew
      last name: Crockett
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 9
    item: Thornton J
      type: Person
      first name: John
      last name: Thornton
      member of: Department of Radiology, Beaumont Hospital, Dublin, Ireland.
  slot:
    index: 10
    item: Nicholson P
      type: Person
      first name: Patrick
      last name: Nicholson
      member of: Royal College of Surgeons in Ireland, Dublin, Ireland.Department of Radiology, Beaumont Hospital, Dublin, Ireland.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1759-8486
has issn l: 1759-8478
has NLM journal title abbreviation: J Neurointerv Surg
publication name: Journal of neurointerventional surgery
language: eng
has national library of medicine journal id: 101517079
derived from: NLM
has place of publication: England
source: J Neurointerv Surg. 2025-02-13;():.

Lifestyle factors associated with benign multiple sclerosis.
pmid: 39947886
abstract: Benign multiple sclerosis (MS), characterised by minimal disability despite long disease duration, remains poorly understood in terms of its determinants and prognostic implications. While lifestyle factors have been implicated in modifying disease progression, their role in distinguishing benign and non-benign MS remains unclear.We conducted a comparative analysis of patients with benign (n=2040) and non-benign MS (n=4283) using data from Swedish nationwide case-control studies with long-term follow-up. Logistic regression models were used to analyse associations between a history of infectious mononucleosis (IM) and lifestyle factors (smoking, body mass index, fish consumption and sun exposure habits) and the likelihood of benign MS. Additionally, Cox regression was used to follow patients with benign MS from the 15-year mark onward, identifying factors associated with the transition to non-benign MS over time.The odds of having benign MS were reduced in association with a history of IM (OR 0.54, 95% CI 0.45 to 0.65), adolescent overweight and obesity (OR 0.69, 95% CI 0.56 to 0.85 and 0.46, 95% CI 0.32 to 0.66, respectively) and infrequent fish consumption (OR 0.72, 95% CI 0.60 to 0.88). Similar associations were observed for the risk of transitioning from benign to non-benign MS over time.A history of IM and modifiable lifestyle factors significantly influence the probability of a benign disease course in MS. These findings underscore the potential for targeted lifestyle interventions to improve MS outcomes. Further research is needed to elucidate the mechanisms by which a past IM infection can continue to influence MS progression long after the initial infection.
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.
has PII: jnnp-2024-335464
doi: 10.1136/jnnp-2024-335464
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Guo J
      type: Person
      first name: Jie
      last name: Guo
      member of: China Agricultural University, Beijing, Beijing, China.
  slot:
    index: 2
    item: Olsson T
      type: Person
      first name: Tomas
      last name: Olsson
      member of: Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
  slot:
    index: 3
    item: Hillert J
      type: Person
      first name: Jan
      last name: Hillert
      member of: Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
  slot:
    index: 4
    item: Alfredsson L
      type: Person
      first name: Lars
      last name: Alfredsson
      member of: Karolinska Institute Institute of Environmental Medicine, Stockholm, Stockholm, Sweden.
  slot:
    index: 5
    item: Hedström AK
      type: Person
      first name: Anna Karin
      last name: Hedström
      member of: Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden anna.hedstrom@ki.se.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:23
e ISSN: 1468-330X
has issn l: 0022-3050
has NLM journal title abbreviation: J Neurol Neurosurg Psychiatry
publication name: Journal of neurology, neurosurgery, and psychiatry
language: eng
has national library of medicine journal id: 2985191R
derived from: NLM
has place of publication: England
source: J Neurol Neurosurg Psychiatry. 2025-02-13;():.

Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications.
pmid: 39947885
abstract: Despite several studies suggesting a potential oligogenic risk model in amyotrophic lateral sclerosis (ALS), case-control statistical evidence implicating oligogenicity with disease risk or clinical outcomes is limited. Considering its direct clinical and therapeutic implications, we aim to perform a large-scale robust investigation of oligogenicity in ALS risk and in the disease clinical course.We leveraged Project MinE genome sequencing datasets (6711 cases and 2391 controls) to identify associations between oligogenicity in known ALS genes and disease risk, as well as clinical outcomes.In both the discovery and replication cohorts, we observed that the risk imparted from carrying multiple ALS rare variants was significantly greater than the risk associated with carrying only a single rare variant, both in the presence and absence of variants in the most well-established ALS genes. However, in contrast to risk, the relationships between oligogenicity and ALS clinical outcomes, such as age of onset and survival, did not follow the same pattern.Our findings represent the first large-scale, case-control assessment of oligogenicity in ALS and show that oligogenic events involving known ALS risk genes are relevant for disease risk in ~6% of ALS but not necessarily for disease onset and survival. This must be considered in genetic counselling and testing by ensuring to use comprehensive gene panels even when a pathogenic variant has already been identified. Moreover, in the age of stratified medication and gene therapy, it supports the need for a complete genetic profile for the correct choice of therapy in all ALS patients.
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.
has PII: jnnp-2024-335364
doi: 10.1136/jnnp-2024-335364
creator: OrderedList
  length: 33
  slot:
    index: 1
    item: Iacoangeli A
      type: Person
      first name: Alfredo
      last name: Iacoangeli
      member of: Department of Biostatistics and Health Informatics, King's College London, London, UK alfredo.iacoangeli@kcl.ac.uk sali.farhan@mcgill.ca.Department of Basic and Clinical Neuroscience, King's College London, London, UK.Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
  slot:
    index: 2
    item: Dilliott AA
      type: Person
      first name: Allison A
      last name: Dilliott
      member of: Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
  slot:
    index: 3
    item: Al Khleifat A
      type: Person
      first name: Ahmad
      last name: Al Khleifat
      member of: Department of Basic and Clinical Neuroscience, King's College London, London, UK.
  slot:
    index: 4
    item: Andersen PM
      type: Person
      first name: Peter M
      last name: Andersen
      member of: Clinical Science, Neurosciences, Umeå Universitet Medicinska Fakulteten, Umea, Sweden.
  slot:
    index: 5
    item: Başak NA
      type: Person
      first name: Nazlı A
      last name: Başak
      member of: Suna and İnan Kıraç Foundation, Neurodegeneration Research Laboratory (NDAL), KUTTAM, Koç University School of Medicine, Istanbul, Turkey.
  slot:
    index: 6
    item: Cooper-Knock J
      type: Person
      first name: Johnathan
      last name: Cooper-Knock
      member of: Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
  slot:
    index: 7
    item: Corcia P
      type: Person
      first name: Philippe
      last name: Corcia
      member of: UMR 1253, Université de Tours, Inserm, Tours, France.Centre de référence sur la SLA, CHU de Tours, Tours, France.
  slot:
    index: 8
    item: Couratier P
      type: Person
      first name: Philippe
      last name: Couratier
      member of: Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.UMR 1094, Université de Limoges, Inserm, Limoges, France.
  slot:
    index: 9
    item: deCarvalho M
      type: Person
      first name: Mamede
      last name: deCarvalho
      member of: Instituto de Fisiologia, Universidade de Lisboa, Lisbon, Portugal.
  slot:
    index: 10
    item: Drory VE
      type: Person
      first name: Vivian E
      last name: Drory
      member of: Department of Neurology, Sourasky Medical Centre, TelAviv, Israel.Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  slot:
    index: 11
    item: Glass JD
      type: Person
      first name: Jonathan D
      last name: Glass
      member of: Neurology, Emory University, Atlanta, Georgia, USA.
  slot:
    index: 12
    item: Gotkine M
      type: Person
      first name: Marc
      last name: Gotkine
      member of: Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.Department of Neurology, Hadassah Medical Center, Jerusalem, Israel.
  slot:
    index: 13
    item: Lerner YM
      type: Person
      first name: Yosef M
      last name: Lerner
      member of: Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.Department of Neurology, Hadassah Medical Center, Jerusalem, Israel.
  slot:
    index: 14
    item: Hardiman O
      type: Person
      first name: Orla
      last name: Hardiman
      member of: Academic Unit of Neurology, Trinity College Dublin, Dublin, Ireland.
  slot:
    index: 15
    item: Landers JE
      type: Person
      first name: John E
      last name: Landers
      member of: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  slot:
    index: 16
    item: McLaughlin RL
      type: Person
      first name: Russell L
      last name: McLaughlin
      member of: Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
  slot:
    index: 17
    item: Pardina JSM
      type: Person
      first name: Jesus S Mora
      last name: Pardina
      member of: ALS Unit, San Rafael Hospital, Madrid, Spain.
  slot:
    index: 18
    item: Morrison K
      type: Person
      first name: Karen
      last name: Morrison
      member of: School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
  slot:
    index: 19
    item: Pinto S
      type: Person
      first name: Susana
      last name: Pinto
      member of: Instituto de Fisiologia, Universidade de Lisboa, Lisbon, Portugal.
  slot:
    index: 20
    item: Povedano M
      type: Person
      first name: Monica
      last name: Povedano
      member of: Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
  slot:
    index: 21
    item: Shaw CE
      type: Person
      first name: Christopher E
      last name: Shaw
      member of: Department of Basic and Clinical Neuroscience, King's College London, London, UK.
  slot:
    index: 22
    item: Shaw PJ
      type: Person
      first name: Pamela J
      last name: Shaw
      member of: Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
  slot:
    index: 23
    item: Silani V
      type: Person
      first name: Vincenzo
      last name: Silani
      member of: Department of Pathophysiology and Transplantation, University of Milan, Milano, Italy.Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  slot:
    index: 24
    item: Ticozzi N
      type: Person
      first name: Nicola
      last name: Ticozzi
      member of: Department of Pathophysiology and Transplantation, University of Milan, Milano, Italy.Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
  slot:
    index: 25
    item: van Damme P
      type: Person
      first name: Philip
      last name: van Damme
      member of: Department of Neuroscience, Leuven Brain Institute (LBI), VIB, Center for Brain and Disease Research, University of Leuven, Leuven, Belgium.Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 26
    item: van den Berg LH
      type: Person
      first name: Leonard H
      last name: van den Berg
      member of: Department of Neurology, University Medical Centre Utrecht Brain Centre, Utrecht, Netherlands.
  slot:
    index: 27
    item: Vourc'h P
      type: Person
      first name: Patrick
      last name: Vourc'h
      member of: UMR 1253, Université de Tours, Inserm, Tours, France.Service de Biochimie et Biologie molécularie, CHU de Tours, Tours, France.
  slot:
    index: 28
    item: Weber M
      type: Person
      first name: Markus
      last name: Weber
      member of: Neuromuscular Diseases Unit, Kantonsspital St. Gallen, St. Gallen, Switzerland.
creator: Project MinE ALS Sequencing Consortium
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:23
e ISSN: 1468-330X
has issn l: 0022-3050
has NLM journal title abbreviation: J Neurol Neurosurg Psychiatry
publication name: Journal of neurology, neurosurgery, and psychiatry
language: eng
has national library of medicine journal id: 2985191R
derived from: NLM
has place of publication: England
source: J Neurol Neurosurg Psychiatry. 2025-02-13;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39947891
pmid: 39947891
abstract: Functional outcomes in patients with acute ischemic stroke (AIS) with large vessel occlusion (LVO) undergoing endovascular treatment (EVT) with successful reperfusion (expanded Thrombolysis In Cerebral Infarction (eTICI) 2b-3) complicated by symptomatic intracranial hemorrhage (sICH) were compared with patients with unsuccessful reperfusion (eTICI 0-2a) without sICH.Patients enrolled in this post hoc analysis were from two Chinese multicenter, randomized controlled trials: the DEVT and the RESCUE BT registries. Patients with AIS who underwent EVT were categorized into two groups according to the state of reperfusion: eTICI 2b-3 with sICH and eTICI 0-2a without sICH. The primary outcome was the modified Rankin Scale (mRS) scores at 90 days. The safety outcomes included early neurological deterioration and 90-day mortality.161 patients were included in this cohort analysis, among whom 71 experienced eTICI 2b-3 with sICH, and 90 had eTICI 0-2a without sICH. After adjusting for potential confounding factors, patients in the eTICI 2b-3 with sICH group had worse mRS at 90 days compared with those in the eTICI 0-2a without sICH group in the adjusted analysis (median 6 (IQR 4-6) vs median 4 (IQR 3-6); adjusted common OR 0.39, 95% CI 0.17 to 0.66). There were also higher rates of very poor outcome (mRS 5-6, 70.4% vs 42.2%; OR 2.90, 95% CI 1.38 to 6.11), mortality (66.2% vs 32.2%; OR 0.48, 95% CI 0.30 to 0.79), and early neurological deterioration (81.7% vs 40.0%; OR 0.16, 95% CI 0.07 to 0.35) in the eTICI 2b-3 with sICH group versus the eTICI 0-2a without sICH group.Successful reperfusion complicated by sICH after EVT was associated with worse outcomes and higher mortality than unsuccessful reperfusion without sICH. These findings emphasize the need for additional efforts in assessing and managing post-EVT-associated sICH to optimize treatment strategies and improve outcomes.Direct Endovascular Treatment for Large Vessel Occlusion Stroke; https://www.chictr.org.cn; ChiCTR-IO[cell cut: 2140 characters, first 2000 kept]
rights: © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: jnis-2024-022869
doi: 10.1136/jnis-2024-022869
creator: OrderedList
  length: 25
  slot:
    index: 1
    item: Li Y
      type: Person
      first name: Yanling
      last name: Li
      member of: Neurology, Shenqiu County People's Hospital, Shenqiu, China.
  slot:
    index: 2
    item: Fu Y
      type: Person
      first name: Yusi
      last name: Fu
      member of: Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
  slot:
    index: 3
    item: Feng X
      type: Person
      first name: Xinggang
      last name: Feng
      member of: Neurology, No. 903 Hospital of PLA Joint Logistic Force, Hangzhou, Zhejiang, China.
  slot:
    index: 4
    item: Chen L
      type: Person
      first name: Lve
      last name: Chen
      member of: Department of Neurology, The First People's Hospital of Shunde, Foshan, Guangdong, China.
  slot:
    index: 5
    item: Luo S
      type: Person
      first name: Shiwei
      last name: Luo
      member of: Neurology, JieYang People's Hospital, JieYang, Guangdong, China.
  slot:
    index: 6
    item: Jiang S
      type: Person
      first name: Shunfu
      last name: Jiang
      member of: neurology, Jingdezhen First People's Hospital, Jingdezhen, Jiangxi, China.
  slot:
    index: 7
    item: Peng H
      type: Person
      first name: Huiyuan
      last name: Peng
      member of: Neurology, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China.
  slot:
    index: 8
    item: Huang X
      type: Person
      first name: Xianjun
      last name: Huang
      member of: Department of Neurology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
  slot:
    index: 9
    item: Zhang W
      type: Person
      first name: Wensheng
      last name: Zhang
      member of: Neurology, Heyuan People's Hospital, Heyuan, Guangdong, China.
  slot:
    index: 10
    item: Huang Y
      type: Person
      first name: Yihong
      last name: Huang
      member of: Neurology, Houjie Hospital and Clinical College of Guangdong Medical University, Dongguan, Guangdong, China.
  slot:
    index: 11
    item: Zhang M
      type: Person
      first name: Min
      last name: Zhang
      member of: Department of Neurology, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
  slot:
    index: 12
    item: Luo G
      type: Person
      first name: Genpei
      last name: Luo
      member of: Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong, China.
  slot:
    index: 13
    item: Ge F
      type: Person
      first name: Fukui
      last name: Ge
      member of: Neurology, Shouguang Jitai health center, Weifang, Shandong, China.
  slot:
    index: 14
    item: Xu J
      type: Person
      first name: Jing
      last name: Xu
      member of: Neurology, Maanshan People's Hospital, Maanshan, Anhui, China.
  slot:
    index: 15
    item: Huang H
      type: Person
      first name: Hanning
      last name: Huang
      member of: Neurology, The People's Hospital of Gaozhou, Maoming, Guangdong, China.
  slot:
    index: 16
    item: Guan M
      type: Person
      first name: Min
      last name: Guan
      member of: Neurology, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
  slot:
    index: 17
    item: Chen Z
      type: Person
      first name: Zhenze
      last name: Chen
      member of: Department of Neurology, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
  slot:
    index: 18
    item: Zi W
      type: Person
      first name: Wenjie
      last name: Zi
      member of: Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China.
  slot:
    index: 19
    item: Yang Q
      type: Person
      first name: Qingwu
      last name: Yang
      member of: Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China.
  slot:
    index: 20
    item: Sang H
      type: Person
      first name: Hongfei
      last name: Sang
      member of: Department of Neurology, Hangzhou First People's Hospital Affiliated of Westlake University School of Medicine, Hangzhou, Zhejiang, China.
  slot:
    index: 21
    item: Qiu Z
      type: Person
      first name: Zhongming
      last name: Qiu
      member of: Neurology, No. 903 Hospital of PLA Joint Logistic Force, Hangzhou, Zhejiang, China.
  slot:
    index: 22
    item: Li M
      type: Person
      first name: Mingchao
      last name: Li
      member of: Neurology, Huaian First People's Hospital, Huaian, Jiangsu, China.
  slot:
    index: 23
    item: Nguyen TN
      type: Person
      first name: Thanh N
      last name: Nguyen
      member of: Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  slot:
    index: 24
    item: Zhao Z
      type: Person
      first name: Zhenqiang
      last name: Zhao
      member of: Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China weiligysy@163.com zhenqiang.zhao@qq.com.
  slot:
    index: 25
    item: Li W
      type: Person
      first name: Wei
      last name: Li
      member of: Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China weiligysy@163.com zhenqiang.zhao@qq.com.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1759-8486
has issn l: 1759-8478
has NLM journal title abbreviation: J Neurointerv Surg
publication name: Journal of neurointerventional surgery
language: eng
has national library of medicine journal id: 101517079
derived from: NLM
has place of publication: England
source: J Neurointerv Surg. 2025-02-13;():.
title: Successful reperfusion accompanied by symptomatic intracranial hemorrhage (sICH) versus unsuccessful reperfusion without sICH after endovascular stroke thrombectomy: a post-hoc analysis of two randomized trials.

New insights on the predictive value of hypoperfusion intensity ratio in thrombectomy: an updated systematic review and meta-analysis with multiple cut-offs.
pmid: 39947893
abstract: The hypoperfusion intensity ratio (HIR) has emerged as a vital measure of tissue-level collateral blood flow, helping to identify patients who are likely to benefit from mechanical thrombectomy (MT). We aimed to assess the HIR's predictive accuracy for clinical outcomes following MT in patients with acute ischemic stroke.PubMed, Embase, and Scopus were searched to identify studies comparing good versus poor HIR groups based on studies' reported cut-offs. We pooled binary outcomes to calculate odds ratios (OR) and continuous outcomes to calculate mean differences (MD) with 95% confidence intervals (95% CI) using random-effects models. PROSPERO registration code: CRD42024609185.14 studies with 2987 patients, 1553 with good HIR and 1434 with poor HIR, were included in this meta-analysis. Patients with poor HIR exhibited a significantly higher baseline infarct volume compared with those with good HIR (MD 30.6 mL, 95% CI 20.8 mL to 40.3 mL, P<0.01), though baseline National Institutes of Health Stroke Scale (NIHSS) (P=0.12) and Alberta Stroke Program Early CT Score (ASPECTS) (P=0.35) were comparable between groups. The rates of infarct growth (MD 22.4 mL, 95% CI 6.7 mL to 38.0 mL, P<0.01) and 3-month mortality (OR 2.18, 95% CI 1.04 to 4.58, P=0.04) were higher among the poor HIR group and good functional recovery (modified Rankin Scale 0-2 at 3 months) was lower (OR 0.58, 95% CI 0.42 to 0.80, P<0.01). The rates of symptomatic intracranial hemorrhage (P=0.37) and successful reperfusion (P=0.47) were comparable among groups.This meta-analysis highlights the significant negative impact of poor HIR on patient outcomes. These findings emphasize the need for personalized treatment strategies for patients with poor HIR.
rights: © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: jnis-2024-023000
doi: 10.1136/jnis-2024-023000
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Jazayeri SB
      type: Person
      first name: Seyed Behnam
      last name: Jazayeri
      member of: Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of) drbehnamjazayeri@gmail.com.
  slot:
    index: 2
    item: Zamarud A
      type: Person
      first name: Aroosa
      last name: Zamarud
      member of: Department of Radiology, Stanford University School of Medicine, Stanford, California, USA.
  slot:
    index: 3
    item: Derhab M
      type: Person
      first name: Mohamed
      last name: Derhab
      member of: Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 4
    item: Ghozy S
      type: Person
      first name: Sherief
      last name: Ghozy
      member of: Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 5
    item: Mirbeyk M
      type: Person
      first name: Mona
      last name: Mirbeyk
      member of: Yale School of Medicine, New Haven, Connecticut, USA.
  slot:
    index: 6
    item: Heit JJ
      type: Person
      first name: Jeremy J
      last name: Heit
      member of: Department of Radiology, Neuroadiology, and Neurointervention Division, Stanford University, Stanford, California, USA.
  slot:
    index: 7
    item: Kallmes DF
      type: Person
      first name: David F
      last name: Kallmes
      member of: Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1759-8486
has issn l: 1759-8478
has NLM journal title abbreviation: J Neurointerv Surg
publication name: Journal of neurointerventional surgery
language: eng
has national library of medicine journal id: 101517079
derived from: NLM
has place of publication: England
source: J Neurointerv Surg. 2025-02-13;():.

Safety and efficacy of low profile flow diverter stents for intracranial aneurysms in small parent vessels: systematic review and meta-analysis.
pmid: 39947895
abstract: This meta-analysis aims to evaluate the clinical and angiographic outcomes of low profile flow diverters (FDs) used in treating intracranial aneurysms in small parent vessels (≤3.5 mm).A systematic review was conducted using Medline, Scopus, and Web of Science databases from inception to October 2024. Studies reporting clinical and angiographic outcomes for Silk Vista Baby, Flow Re-direction Endoluminal Device Junior (FRED Jr), and p48 MW Flow Modulation Device were included. Favorable outcomes were defined as those reported directly in studies or as a modified Rankin Scale score of 0-2.33 studies involving 998 patients with 1049 aneurysms were analyzed. Favorable neurological outcomes were reported in 94% of cases overall, with unruptured aneurysms achieving better outcomes (97.1%) than ruptured aneurysms (80%). Procedure related complications were observed in 15.7% of cases, with a lower rate in unruptured aneurysms (12.7%) compared with ruptured aneurysms (20%). Complete or near complete occlusion was achieved in 79.5% of aneurysms from 28 studies, with similar rates for both unruptured (73.6%, from 14 studies) and ruptured (74%, from 13 studies) aneurysms. Among devices, the FRED Jr showed the highest favorable outcome rate (97.6%), while the p48 MW device had the highest complication rate (17.2%). Adjunctive coiling did not significantly affect neurological outcomes but was associated with a slightly lower complication rate (12.1%).Low profile FDs demonstrated high rates of favorable neurological outcomes in small parent vessel aneurysms, particularly in unruptured cases. These FDs achieved acceptable rates of adequate aneurysm occlusion and complications.
rights: © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: jnis-2024-022834
doi: 10.1136/jnis-2024-022834
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Elek A
      type: Person
      first name: Alperen
      last name: Elek
      member of: Interventional Radiology, Ege University Faculty of Medicine, Izmir, Turkey.
  slot:
    index: 2
    item: Karagoz S
      type: Person
      first name: Sidar
      last name: Karagoz
      member of: Dicle University Medical Faculty, Diyarbakir, Turkey.
  slot:
    index: 3
    item: Dindar GN
      type: Person
      first name: Gülfem Nur
      last name: Dindar
      member of: Gazi University Faculty of Medicine, Ankara, Turkey.
  slot:
    index: 4
    item: Yucel S
      type: Person
      first name: Semra
      last name: Yucel
      member of: Ministry of Health İzmir Katip Çelebi University Atatürk Education and Research Hospital, Izmir, Turkey.
  slot:
    index: 5
    item: Cinar C
      type: Person
      first name: Celal
      last name: Cinar
      member of: Interventional Radiology, Ege University Faculty of Medicine, Izmir, Turkey.
  slot:
    index: 6
    item: Kusbeci M
      type: Person
      first name: Mahmut
      last name: Kusbeci
      member of: Interventional Radiology, Ege University Faculty of Medicine, Izmir, Turkey.
  slot:
    index: 7
    item: Ozturk E
      type: Person
      first name: Egemen
      last name: Ozturk
      member of: Department of Radiology, Usak Training and Research Hospital, Usak, Turkey.
  slot:
    index: 8
    item: Oran I
      type: Person
      first name: Ismail
      last name: Oran
      member of: Interventional Radiology, Ege University Faculty of Medicine, Izmir, Turkey ismailoran@gmail.com.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1759-8486
has issn l: 1759-8478
has NLM journal title abbreviation: J Neurointerv Surg
publication name: Journal of neurointerventional surgery
language: eng
has national library of medicine journal id: 101517079
derived from: NLM
has place of publication: England
source: J Neurointerv Surg. 2025-02-13;():.

Early brain MRI changes following transvenous embolization of cerebrospinal fluid-venous fistulas in spontaneous intracranial hypotension.
pmid: 39947894
abstract: To evaluate early and mid-term imaging and clinical outcomes following transvenous embolization of cerebrospinal fluid-venous fistulas (CSFVFs) in patients with spontaneous intracranial hypotension (SIH).From November 2022 to November 2024, 60 consecutive patients with SIH and confirmed CSFVF underwent transvenous embolization using Onyx. Of these, 40 patients underwent brain MRI pre-treatment, 24 hours post-treatment, and at a 3-month follow-up. The primary outcome was regression of brain MRI abnormalities at 24 hours and 3 months. Secondary outcomes included rates of symptom improvement, predictors of clinical improvement, and complication rates.The mean patient age was 61 years, and 65% were female. All procedures were technically successful. The median SIH score significantly decreased from 6 pre-treatment to 3.5 at 24 hours (P=0.01) and to 2 at 3 months (P=0.004). Early improvement in SIH score correlated with clinical improvement at 24 hours (P=0.002), which was observed in 77.5% of patients. Pachymeningeal enhancement (87.5%) and venous sinus engorgement (75%) were the most common MRI abnormalities. Both findings regressed in approximately 50% of patients at 24 hours and in 80% of patients at 3 months. At 3 months, 82.5% of patients achieved complete clinical recovery. Rebound post-treatment headaches occurred in 32.5% of patients but resolved within 7 days. The morbidity rate was 0%.Transvenous embolization of CSFVFs results in early and sustained clinical and imaging improvements in patients with SIH. These findings support the efficacy of this intervention as a primary treatment for CSFVFs.
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: jnis-2024-022957
doi: 10.1136/jnis-2024-022957
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Cagnazzo F
      type: Person
      first name: Federico
      last name: Cagnazzo
      member of: Department of Neuroradiology, University Hospital of Montpellier, Montpellier, France f-cagnazzo@chu-montpellier.fr.
  slot:
    index: 2
    item: Le Bars E
      type: Person
      first name: Emmanuelle
      last name: Le Bars
      member of: Department of Neuroradiology, University Hospital of Montpellier, Montpellier, France.
  slot:
    index: 3
    item: Risi G
      type: Person
      first name: Gaetano
      last name: Risi
      member of: Department of Neuroradiology, University Hospital of Montpellier, Montpellier, France.
  slot:
    index: 4
    item: Lonjon N
      type: Person
      first name: Nicolas
      last name: Lonjon
      member of: Department of Neurosurgery, University Hospital Centre Montpellier, Montpellier, France.
  slot:
    index: 5
    item: van Dokkum LEH
      type: Person
      first name: Liesjet E H
      last name: van Dokkum
      member of: Department of Neuroradiology, University Hospital of Montpellier, Montpellier, France.
  slot:
    index: 6
    item: Corti L
      type: Person
      first name: Lucas
      last name: Corti
      member of: Department of Neurology, Hospital Gui de Chauliac, Montpellier, France.
  slot:
    index: 7
    item: Costalat V
      type: Person
      first name: Vincent
      last name: Costalat
      member of: Department of Neuroradiology, University Hospital of Montpellier, Montpellier, France.Neuroradiology, CHRU Gui de Chauliac, Montpellier, France.
  slot:
    index: 8
    item: Ducros A
      type: Person
      first name: Anne
      last name: Ducros
      member of: Department of Neurology, Hospital Gui de Chauliac, Montpellier, France.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1759-8486
has issn l: 1759-8478
has NLM journal title abbreviation: J Neurointerv Surg
publication name: Journal of neurointerventional surgery
language: eng
has national library of medicine journal id: 101517079
derived from: NLM
has place of publication: England
source: J Neurointerv Surg. 2025-02-13;():.

Real-world experience of renal outcomes and management of PrEP users with estimated glomerular filtration rates less than 60 mL/min/1.73 m2.
pmid: 39947896
abstract: This retrospective service evaluation reviews practical measures for pre-exposure prophylaxis (PrEP) users with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 Of 35 724 PrEP users, 361 had an eGFR <60 mL/min/1.73 m2, of whom 16% required non-tenofovir disoproxil/emtricitabine PrEP formulations. Majority of cases required simple and conservative management, with repeat sampling and/or stopping of the supplements and/or recreational drugs.
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.
has PII: sextrans-2024-056411
doi: 10.1136/sextrans-2024-056411
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Tittle V
      type: Person
      first name: Victoria
      last name: Tittle
      member of: 56 Dean Street, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK victoria.tittle@nhs.net.
  slot:
    index: 2
    item: Girometti N
      type: Person
      first name: Nicolo
      last name: Girometti
      member of: 56 Dean Street, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
  slot:
    index: 3
    item: Goodfellow JJ
      type: Person
      first name: Jonathan Joseph
      last name: Goodfellow
      member of: Department of HIV/GUM, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
  slot:
    index: 4
    item: Cole S
      type: Person
      first name: Stephen
      last name: Cole
      member of: Department of HIV/GUM, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
  slot:
    index: 5
    item: Patel S
      type: Person
      first name: Sheel
      last name: Patel
      member of: 56 Dean Street, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
  slot:
    index: 6
    item: Boffito M
      type: Person
      first name: Marta
      last name: Boffito
      member of: GenitoUrinary and HIV Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
  slot:
    index: 7
    item: McCormack S
      type: Person
      first name: Sheena
      last name: McCormack
      member of: MRC CTU, University College London, London, UK.
  slot:
    index: 8
    item: Jones R
      type: Person
      first name: Rachael
      last name: Jones
      member of: GenitoUrinary and HIV Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1472-3263
has issn l: 1368-4973
has NLM journal title abbreviation: Sex Transm Infect
publication name: Sexually transmitted infections
language: eng
has national library of medicine journal id: 9805554
derived from: NLM
has place of publication: England
source: Sex Transm Infect. 2025-02-13;():.

Early Axial Spondyloarthritis Detection: Two-Year Follow-up of the Sp-EYE Study on Acute Anterior Uveitis and Chronic Back Pain Screening.
pmid: 39947898
abstract: In the previous Spondyloarthritis EYE study, we confirmed the potential of a screening strategy for early axial spondyloarthritis (axSpA) detection using acute anterior uveitis (AAU) and chronic back pain (CBP) as referral criteria. This follow-up study assessed changes in diagnostic categories (definite, suspected, and no axSpA) over 2 years and identified baseline factors predicting axSpA diagnosis at 24 months.Patients with AAU and CBP were categorized into 3 groups: definite axSpA, suspected of axSpA, and no axSpA, based on clinical and radiographic data within 6 months after baseline. Suspected cases were monitored for 24 months, with the possibility of reclassification. A competing risk analysis was used to estimate the probability of transitioning from suspected of axSpA to definite axSpA or no axSpA, and logistic regression analysis was employed to determine if baseline factors could predict definite axSpA at 24 months.Among 81 patients, 26 were classified as no axSpA, 36 as suspected of axSpA, and 19 as definite axSpA. At 24 months, suspected patients had an 18% probability to transition to definite axSpA (4 cases) and a 60% to no axSpA (15 cases). Significant predictors of axSpA diagnosis included the following: HLA-B27 positivity, good response to nonsteroidal anti-inflammatory drugs, inflammatory back pain, increasing C-reactive protein levels, buttock pain, and higher Bath Ankylosing Spondylitis Metrology Index scores.Our screening strategy identified approximately one third of previously undiagnosed axSpA cases among patients with AAU and CBP, mostly at baseline, with few additional cases at follow-up. The predictors revealed in this study could aid physicians in estimating axSpA disease probability.
rights: Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 00124743-990000000-00315
doi: 10.1097/RHU.0000000000002202
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Hellamand P
      type: Person
      first name: Pasoon
      last name: Hellamand
  slot:
    index: 2
    item: van de Sande MGH
      type: Person
      first name: Marleen G H
      last name: van de Sande
  slot:
    index: 3
    item: van Bentum RE
      type: Person
      first name: Rianne E
      last name: van Bentum
      member of: Departments of Rheumatology and Ophthalmology, Amsterdam UMC, Free University Amsterdam, Amsterdam, the Netherlands.
  slot:
    index: 4
    item: Verbraak FD
      type: Person
      first name: Frank D
      last name: Verbraak
      member of: Department of Ophthalmology, Amsterdam UMC, Free University Amsterdam, Amsterdam, the Netherlands.
  slot:
    index: 5
    item: Twisk JWR
      type: Person
      first name: Jos W R
      last name: Twisk
      member of: Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, the Netherlands.
  slot:
    index: 6
    item: van der Horst Bruinsma I
      type: Person
      first name: Irene
      last name: van der Horst Bruinsma
      member of: Department of Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T21:33
e ISSN: 1536-7355
has issn l: 1076-1608
has NLM journal title abbreviation: J Clin Rheumatol
publication name: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
language: eng
has national library of medicine journal id: 9518034
derived from: NLM
has place of publication: United States
source: J Clin Rheumatol. 2025-02-14;():.

Relative importance and interactions of factors influencing low-value care provision: a factorial survey experiment among Swedish primary care physicians.
pmid: 39947899
abstract: Low-value care (LVC) describes practices that persist in healthcare, despite being ineffective, inefficient or causing harm. Several determinants for the provision of LVC have been identified, but understanding how these factors influence professionals' decisions, individually and jointly, is a necessary next step to guide deimplementation.A factorial survey experiment was employed using vignettes that presented hypothetical medical scenarios among 593 Swedish primary care physicians. Each vignette varied systematically by factors such as patient age, patient request for the LVC, physician's perception of this practice, practice cost to the primary care centre and time taken to deliver it. For each scenario, we measured the reported likelihood of providing the LVC. We collected information on the physician's worry about missing a serious illness.Patient requests and physicians' positive perceptions of the practice were the factors that increased the reported likelihood of providing LVC the most (by 14 and 13 percentage points (pp), respectively). When the LVC was low in cost or not time-consuming, patient requests further boosted the likelihood of provision by 29 and 18 pp. In contrast, credible evidence against the LVC reduced the role of patient requests by 11 pp. Physicians' fear of missing a serious illness was linked with higher reported probability of providing LVC, and the credibility of the evidence against the LVC reduced the role of this concern.The findings highlight that patient requests enhance the role of many determinants, while the credibility of evidence diminishes the impact of others. Overall, these findings point to the relevance of increased clinician knowledge about LVC, tools for patient communication and the use of decision support tools to reduce the uncertainty in decision-making.
rights: © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.
has PII: bmjqs-2024-018045
doi: 10.1136/bmjqs-2024-018045
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Roczniewska M
      type: Person
      first name: Marta
      last name: Roczniewska
      member of: Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden marta.roczniewska@ki.se.Institute of Psychology, SWPS University, Warszawa, Poland.
  slot:
    index: 2
    item: Augustsson H
      type: Person
      first name: Hanna
      last name: Augustsson
      member of: Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.Center for Epidemiology and Community Medicine, Stockholms Lans Landsting, Stockholm, Sweden.
  slot:
    index: 3
    item: Ingvarsson S
      type: Person
      first name: Sara
      last name: Ingvarsson
      member of: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  slot:
    index: 4
    item: Hedberg Rundgren E
      type: Person
      first name: Emma
      last name: Hedberg Rundgren
      member of: Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
  slot:
    index: 5
    item: Szymański K
      type: Person
      first name: Kamil
      last name: Szymański
      member of: Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
  slot:
    index: 6
    item: von Thiele Schwarz U
      type: Person
      first name: Ulrica
      last name: von Thiele Schwarz
      member of: Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.School of Health, Care and Social Welfare, Mälardalens universitet, Västerås, Sweden.
  slot:
    index: 7
    item: Nilsen P
      type: Person
      first name: Per
      last name: Nilsen
      member of: Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
  slot:
    index: 8
    item: Hasson H
      type: Person
      first name: Henna
      last name: Hasson
      member of: Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.Center for Epidemiology and Community Medicine, Stockholms Lans Landsting, Stockholm, Sweden.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 2044-5423
has issn l: 2044-5415
has NLM journal title abbreviation: BMJ Qual Saf
publication name: BMJ quality & safety
language: eng
has national library of medicine journal id: 101546984
derived from: NLM
has place of publication: England
source: BMJ Qual Saf. 2025-02-13;():.

Fifteen-minute consultation: Should I get my child the varicella (chickenpox) vaccine?
pmid: 39947900
abstract: The Joint Committee on Vaccination and Immunisation (JCVI) has recently recommended the introduction of the varicella (chickenpox) vaccine into the UK's routine childhood immunisation schedule. This was previously only available to a small group of eligible children or through private healthcare providers. Engaging families in conversations around vaccines is recognised as important for informed decision-making, and professionals leading these discussions need to be confident and well-informed. This article aims to provide an overview of the evidence behind the decision to introduce varicella (chickenpox) vaccine, and addresses anticipated questions.
rights: © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: archdischild-2024-327700
doi: 10.1136/archdischild-2024-327700
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: O'Mahony E
      type: Person
      first name: Elizabeth
      last name: O'Mahony
      member of: Imperial College Healthcare NHS Trust, London, UK.
  slot:
    index: 2
    item: Bedford H
      type: Person
      first name: Helen
      last name: Bedford
      member of: Great Ormond Street Institute of Child Health, University College London, London, WC1N 1EH, UK.
  slot:
    index: 3
    item: Marlow R
      type: Person
      first name: Robin
      last name: Marlow
      member of: Paediatric Emergency Department, Bristol Royal Hospital for Children, Bristol, UK.Population Health Sciences, University of Bristol, Bristol, UK.
  slot:
    index: 4
    item: Sherman SM
      type: Person
      first name: Susan M
      last name: Sherman
      member of: School of Psychology, The University of Sheffield, Sheffield, UK.
  slot:
    index: 5
    item: Whittaker E
      type: Person
      first name: Elizabeth
      last name: Whittaker
      member of: Paediatric Infectious Diseases, West London Children's Healthcare, Imperial College Healthcare NHS Trust, London, UK.
  slot:
    index: 6
    item: Fitzgerald F
      type: Person
      first name: Felicity
      last name: Fitzgerald
      member of: Imperial College London, London, UK f.fitzgerald@imperial.ac.uk.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:33
e ISSN: 1743-0593
has issn l: 1743-0585
has NLM journal title abbreviation: Arch Dis Child Educ Pract Ed
publication name: Archives of disease in childhood. Education and practice edition
language: eng
has national library of medicine journal id: 101220684
derived from: NLM
has place of publication: England
source: Arch Dis Child Educ Pract Ed. 2025-02-13;():.

Evidence for altered immune-structural cell crosstalk in cystic fibrosis revealed by single cell transcriptomics.
pmid: 39947933
abstract: Chronic pulmonary inflammation strongly contributes to respiratory failure and mortality in patients with cystic fibrosis (pwCF). Effective anti-microbial immunity and maintaining lung homeostasis require continuous structural-immune cell communication. Whether and how this crosstalk is altered in CF remains poorly understood, obscuring potential new angles for therapy development to restore airway homeostasis in pwCF.We performed droplet-based single cell RNA-sequencing on bronchial biopsies from pwCF to investigate structural-immune cell crosstalk. Computational analyses were used to compare these data to samples obtained from healthy controls.CF airway wall biopsies showed lower proportions and altered transcriptomes of basal cells, submucosal gland cells and endothelial cells, and a higher abundance of ciliated cells, monocytes, macrophages and T cells. Both B and T lymphocytes displayed aberrantly activated phenotypes with transcriptional changes linked to hypoxia and vascular endothelial growth factor signaling, indicative of crosstalk with endothelial cells. The CF lung displayed unique changes in intercellular communication potential involving ionocytes, macrophages, endothelial cells and lymphocytes. This included interactions between HLA-E on structural cells and the druggable CD94/NKG2A immune checkpoint on CD8+T cells.We report the first single cell transcriptome atlas of the CF lung containing the full spectrum of structural and immune cells, providing a valuable resource for investigating changes to cellular composition, phenotypes and crosstalk linked to CF. Our analyses highlight dysregulated basal cell function and adaptive immunity in pwCF - despite favorable responses to CFTR modulator therapy. We identify novel aspects of CF pathophysiology and potential entry points for therapeutic strategies.
rights: Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
has PII: S1569-1993(25)00049-9
doi: 10.1016/j.jcf.2025.01.016
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Berg M
      type: Person
      first name: Marijn
      last name: Berg
      member of: Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; GRIAC research institute, University Medical Center Groningen, Groningen, Netherlands.
  slot:
    index: 2
    item: Krabbendam L
      type: Person
      first name: Lisette
      last name: Krabbendam
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 3
    item: van der Ploeg EK
      type: Person
      first name: Esmee K
      last name: van der Ploeg
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 4
    item: van Nimwegen M
      type: Person
      first name: Menno
      last name: van Nimwegen
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 5
    item: van der Veer T
      type: Person
      first name: Tjeerd
      last name: van der Veer
      member of: Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 6
    item: Banchero M
      type: Person
      first name: Martin
      last name: Banchero
      member of: Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; GRIAC research institute, University Medical Center Groningen, Groningen, Netherlands.
  slot:
    index: 7
    item: Carpaij OA
      type: Person
      first name: Orestes A
      last name: Carpaij
      member of: Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; GRIAC research institute, University Medical Center Groningen, Groningen, Netherlands.
  slot:
    index: 8
    item: Hoogenboezem R
      type: Person
      first name: Remco
      last name: Hoogenboezem
      member of: Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 9
    item: van den Berge M
      type: Person
      first name: Maarten
      last name: van den Berge
      member of: Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; GRIAC research institute, University Medical Center Groningen, Groningen, Netherlands.
  slot:
    index: 10
    item: Bindels E
      type: Person
      first name: Eric
      last name: Bindels
      member of: Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 11
    item: Aerts JGJV
      type: Person
      first name: Joachim G J V
      last name: Aerts
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 12
    item: Collin A
      type: Person
      first name: Antoine
      last name: Collin
      member of: Université Côte d'Azur, Centre National de la Recherche Scientifique and INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 3IA Côte d'Azur, IHU Respirera, Sophia Antipolis, France.
  slot:
    index: 13
    item: Barbry P
      type: Person
      first name: Pascal
      last name: Barbry
      member of: Université Côte d'Azur, Centre National de la Recherche Scientifique and INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 3IA Côte d'Azur, IHU Respirera, Sophia Antipolis, France.
  slot:
    index: 14
    item: Kamphuis LS
      type: Person
      first name: Lieke S
      last name: Kamphuis
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 15
    item: Hendriks RW
      type: Person
      first name: Rudi W
      last name: Hendriks
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
  slot:
    index: 16
    item: Nawijn MC
      type: Person
      first name: Martijn C
      last name: Nawijn
      member of: Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; GRIAC research institute, University Medical Center Groningen, Groningen, Netherlands.
  slot:
    index: 17
    item: Stadhouders R
      type: Person
      first name: Ralph
      last name: Stadhouders
      member of: Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands. Electronic address: r.stadhouders@erasmusmc.nl.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T21:58
e ISSN: 1873-5010
has issn l: 1569-1993
has NLM journal title abbreviation: J Cyst Fibros
publication name: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
language: eng
has national library of medicine journal id: 101128966
derived from: NLM
has place of publication: Netherlands
source: J Cyst Fibros. 2025-02-12;():.

Metabolic control of replisome plasticity in genome surveillance.
pmid: 39947938
abstract: Metabolic pathways and DNA replication are both adaptable and essential for early development and cancer progression. While each process is well understood individually, the mechanisms coordinating them are just beginning to emerge. Nucleotide biosynthesis serves as a crucial link, with fluctuating nucleotide pools leading to imbalanced deoxyribonucleotide (dNTP) and increased ribonucleotide (rNTP) levels, impairing DNA synthesis and triggering replication stress; ultimately driving developmental disorders and cancer. To counter these challenges, the replisome - the core machinery of DNA replication - continuously adjusts its architecture and speed in response to physiological changes, including nucleotide fluctuations. This review outlines recent insights into how the replisome aligns its function with metabolic changes in nucleotide levels and explores emerging links between metabolism and genome stability, and their roles in development and disease.
rights: Copyright © 2025 Elsevier Ltd. All rights reserved.
has PII: S0962-8924(25)00028-5
doi: 10.1016/j.tcb.2025.01.006
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Petersen MB
      type: Person
      first name: Mikkel Bo
      last name: Petersen
      member of: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230, Odense, Denmark.
  slot:
    index: 2
    item: Chhetri G
      type: Person
      first name: Gita
      last name: Chhetri
      member of: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230, Odense, Denmark.
  slot:
    index: 3
    item: Somyajit K
      type: Person
      first name: Kumar
      last name: Somyajit
      member of: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230, Odense, Denmark. Electronic address: ksom@sdu.dk.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T21:58
e ISSN: 1879-3088
has issn l: 0962-8924
has NLM journal title abbreviation: Trends Cell Biol
publication name: Trends in cell biology
language: eng
has national library of medicine journal id: 9200566
derived from: NLM
has place of publication: England
source: Trends Cell Biol. 2025-02-12;():.

Diagnostic and interventional paediatric bronchoscopy in low and middle-income countries.
pmid: 39947950
abstract: To investigate the role of both diagnostic and interventional paediatric bronchoscopy in the management of respiratory diseases in children in low- and middle-income countries (LMICs).A review of published English literature from January 2014 to February 2024.Indications for bronchoscopy in LMICs will vary depending on the burden of infectious diseases like tuberculosis (TB) and HIV, and the expertise and equipment available. TB diagnosis in children remains challenging due to the paucibacillary nature of the disease and its overlap with other infectious diseases like actinomycosis and echinococcosis. Acquired conditions, such as foreign body (FB) inhalation, present late with a high complication rate, making them challenging to manage. Paediatric bronchoscopy has an important role in the diagnoses, management and follow-up of many of these conditions. Interventional procedures like endobronchial ultrasound (EBUS), radial EBUS and cryotherapy enhance diagnostic and management capabilities.Children in LMICs are affected by both infectious and acquired conditions. Bronchoscopy remains expensive with limited training offered in LMICs but is increasingly recognised for its important diagnostic and therapeutic role.
rights: Copyright © 2025. Published by Elsevier Ltd.
has PII: S1526-0542(25)00007-7
doi: 10.1016/j.prrv.2025.01.005
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Goussard P
      type: Person
      first name: Pierre
      last name: Goussard
      member of: Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa. Electronic address: pgouss@sun.ac.za.
  slot:
    index: 2
    item: Eber E
      type: Person
      first name: Ernst
      last name: Eber
      member of: Division of Paediatric Pulmonology and Allergology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
  slot:
    index: 3
    item: Frigati L
      type: Person
      first name: Lisa
      last name: Frigati
      member of: Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
  slot:
    index: 4
    item: Greybe L
      type: Person
      first name: Leonore
      last name: Greybe
      member of: Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
  slot:
    index: 5
    item: Venkatakrishna SSB
      type: Person
      first name: Shyam Sunder B
      last name: Venkatakrishna
      member of: Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  slot:
    index: 6
    item: Janson J
      type: Person
      first name: Jacques
      last name: Janson
      member of: Division of Cardiothoracic Surgery, Department of Surgical Sciences, Stellenbosch University, and Tygerberg Hospital, Tygerberg, South Africa.
  slot:
    index: 7
    item: Ismail Z
      type: Person
      first name: Zane
      last name: Ismail
      member of: Division of Cardiothoracic Surgery, Department of Surgical Sciences, Stellenbosch University, and Tygerberg Hospital, Tygerberg, South Africa.
  slot:
    index: 8
    item: Gie A
      type: Person
      first name: Andre
      last name: Gie
      member of: Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
  slot:
    index: 9
    item: Rhode D
      type: Person
      first name: Delano
      last name: Rhode
      member of: Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
  slot:
    index: 10
    item: Schubert P
      type: Person
      first name: Pawel
      last name: Schubert
      member of: Division of Anatomical Pathology, Tygerberg Hospital, National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  slot:
    index: 11
    item: Merven M
      type: Person
      first name: Marc
      last name: Merven
      member of: Division of Otorhinolaryngology, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
  slot:
    index: 12
    item: Andronikou S
      type: Person
      first name: Savvas
      last name: Andronikou
      member of: Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-03
dp: 2025 Feb 03
created: 2025-2-13T21:58
e ISSN: 1526-0550
has issn l: 1526-0542
has NLM journal title abbreviation: Paediatr Respir Rev
publication name: Paediatric respiratory reviews
language: eng
has national library of medicine journal id: 100898941
derived from: NLM
has place of publication: England
source: Paediatr Respir Rev. 2025-02-03;():.

Screening for Work-Related Voice Disorders in Teachers.
pmid: 39947967
abstract: This study aimed to assess the prevalence and analyze characteristics and symptoms of non-infectious sore-throat in teachers.Adult persons employed as teachers were screened for non-infectious sore throat. A cross-sectional study was performed in patients with non-infectious sore throat confirmed based on clinical examination.Out of 1008 teachers who participated in the screening, non-infectious sore throat was found in 70 respondents (6.9%). Most of the participants with non-infectious sore throat were women with a mean age of 45.5 years and a mean length of service 18.1 years. A small number of participants (n = 7, 10%) often visited a medical doctor because of throat problems. Over 80% of participants commonly used throat therapeutic agents. The most common symptoms were dry throat, tickling, and scratching in the throat. The oropharyngeal mucosa in most subjects was slightly red to red, the tonsils were normal, and there was no oropharyngeal enanthema. The median subjective assessments using the visual analog scale from zero to ten were four (interquartile range (IQR) 0-5) for pain, four (IQR 1-5) for difficulty in swallowing, and two (IQR 0-4) for swelling of the pharynx back wall. Of the analyzed risk factors, the highest percentages of participants were using air conditioning and consuming chilled and carbonated drinks, 21.4% were smokers and 10% of participants had a confirmed respiratory allergy.The prevalence of non-infectious sore throat was 6.9% with the most common symptoms being dry throat, tickling, and scratching in the throat. While a small percentage of participants often visited a medical doctor because of throat problems, the majority of them used throat therapeutic agents. Additional multicentric prospective studies are needed to increase our knowledge about symptoms and therapeutic strategies for non-infectious sore throat and voice disorders in general.
rights: Copyright © 2025 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
has PII: S0892-1997(25)00029-3
doi: 10.1016/j.jvoice.2025.01.035
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Hrkić S
      type: Person
      first name: Selma
      last name: Hrkić
      member of: Institute of Occupational and Sports Medicine of Zenica-Doboj Canton, Zenica, Bosnia and Herzegovina.
  slot:
    index: 2
    item: Mehanović E
      type: Person
      first name: Elvir
      last name: Mehanović
      member of: Institute of Occupational and Sports Medicine of Zenica-Doboj Canton, Zenica, Bosnia and Herzegovina.
  slot:
    index: 3
    item: Tanković A
      type: Person
      first name: Alma
      last name: Tanković
      member of: Institute of Occupational and Sports Medicine of Zenica-Doboj Canton, Zenica, Bosnia and Herzegovina.
  slot:
    index: 4
    item: Šukalo A
      type: Person
      first name: Aziz
      last name: Šukalo
      member of: Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina.
  slot:
    index: 5
    item: Tanović Avdić A
      type: Person
      first name: Amna
      last name: Tanović Avdić
      member of: Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina.
  slot:
    index: 6
    item: Mehić M
      type: Person
      first name: Meliha
      last name: Mehić
      member of: Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina.
  slot:
    index: 7
    item: Pilipović S
      type: Person
      first name: Saša
      last name: Pilipović
      member of: Pharmaceutical Faculty, University of Tuzla, Tuzla, Bosnia and Herzegovina.
  slot:
    index: 8
    item: Pilipović B
      type: Person
      first name: Berina
      last name: Pilipović
      member of: Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina; Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina.
  slot:
    index: 9
    item: Glamočlija U
      type: Person
      first name: Una
      last name: Glamočlija
      member of: Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina; University of Sarajevo - Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina. Electronic address: UnaG@Bosnalijek.ba.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T21:59
e ISSN: 1873-4588
has issn l: 0892-1997
has NLM journal title abbreviation: J Voice
publication name: Journal of voice : official journal of the Voice Foundation
language: eng
has national library of medicine journal id: 8712262
derived from: NLM
has place of publication: United States
source: J Voice. 2025-02-12;():.

Finite element analysis of biomechanical effects of oversized total talar prosthesis and collateral ligament reconstruction on total talar replacement.
pmid: 39947960
abstract: Total talar replacement (TTR) using a personalized customized total talar prosthesis (TTP) is an emerging and promising surgical option for the treatment of ankle problems. However, how to solve ankle instability after total talar replacement, and the influence of related solutions on foot biomechanics has not been investigated.Our preliminary studies have found that enlarging a personalized total talar prosthesis (TTP0) by 1.5 % along the coronal axis (TTP-FP1.5) and reconstructing the anterior talofibular ligament (ATFL) significantly can enhance ankle stability. However, there is a lack of insight into the effect of the two options on biomechanics. Consequently, this work constructed anatomically detailed finite element models of the foot, including an intact model and four surgical models, including replacement of TTP0, replacement of TTP-FP1.5, and two models of TTP-coupled ATFL reconstruction. Biomechanical differences were evaluated by numerical simulation of a balanced-standing and three characteristic instants of the stand phase.Changes in plantar pressure distribution, joint contact pressure and force transmission, von Mises stress on bone, and prosthesis stress were predicted and analyzed. It was found that significant changes in foot biomechanics occurred after TTP-FP1.5 replacement compared to TTP0 replacement. In contrast, no ligament reconstruction versus ATFL reconstruction exerts a minor effect on biomechanics.The findings indicate that the shape of the prosthesis is the primary factor affecting foot biomechanics after total talar replacement. In contrast, reconstruction of the ATFL has only a minimal effect on the biomechanics of the foot. The above findings will provide a solid basis for the improvement of TTR surgical plans in clinical.
rights: Copyright © 2025 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
has PII: S1268-7731(25)00034-7
doi: 10.1016/j.fas.2025.02.003
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Li H
      type: Person
      first name: Hao
      last name: Li
      member of: Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment, Ministry of Education, Hunan University, Changsha, China.
  slot:
    index: 2
    item: Xie H
      type: Person
      first name: Haitao
      last name: Xie
      member of: XingGuo people's Hospital, Jiangxi, China.
  slot:
    index: 3
    item: Li Y
      type: Person
      first name: Yuanqiang
      last name: Li
      member of: Sports Medicine Center, First Affiliated Hospital of The Army Medical University, Chongqing, China.
  slot:
    index: 4
    item: Chen W
      type: Person
      first name: Wan
      last name: Chen
      member of: Sports Medicine Center, First Affiliated Hospital of The Army Medical University, Chongqing, China. Electronic address: chenwanfred@foxmail.com.
  slot:
    index: 5
    item: Xie H
      type: Person
      first name: Haiqiong
      last name: Xie
      member of: School of Advanced Manufacturing Engineering, Chongqing University of Posts and Telecommunications, Chongqing, China; Chongqing Institute of Bio-Intelligent Manufacturing, Chongqing, China. Electronic address: xiehq@cqupt.edu.cn.
  slot:
    index: 6
    item: Cai X
      type: Person
      first name: Xu
      last name: Cai
      member of: Department of Orthopedics, The Third Xiangya Hospital of Central South University, Department of Spinal Surgery, Hunan Xiangya Boai Rehabilitation Hospital, Changsha, China. Electronic address: upercai@163.com.
  slot:
    index: 7
    item: Wei K
      type: Person
      first name: Kai
      last name: Wei
      member of: Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment, Ministry of Education, Hunan University, Changsha, China; Chongqing Institute of Bio-Intelligent Manufacturing, Chongqing, China. Electronic address: weikai@hnu.edu.cn.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-08
dp: 2025 Feb 08
created: 2025-2-13T21:58
e ISSN: 1460-9584
has issn l: 1268-7731
has NLM journal title abbreviation: Foot Ankle Surg
publication name: Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
language: eng
has national library of medicine journal id: 9609647
derived from: NLM
has place of publication: France
source: Foot Ankle Surg. 2025-02-08;():.

The Efficacy of Gender-Affirming Voice and Communication Therapy-A Systematic Review.
pmid: 39947968
abstract: The World Professional Association for Transgender Health (2022) recommend voice and communication therapy within their standards of care for transgender and gender-diverse individuals; however, there is currently limited data to address the efficacy of interventions for this population beyond changes to fundamental frequencies. This systematic review will explore (1) the efficacy of voice and communication therapy for supporting trans and gender-diverse individuals in decreasing gender incongruence and will (2) consider the most effective modes and models of intervention for attaining this goal.Systematic review.A systematic literature search was undertaken through the online databases Scopus, Cochrane Library, PsycInfo, and PubMed, based upon a population, intervention, comparison, outcomes search strategy, with an additional paper being included from manual citation searches. For inclusion, studies were required to address purely non-surgical interventions and, to appropriately align with a contemporary understanding of therapeutic efficacy, to include patient self-rating outcome measures alongside acoustic measures.Eight pertinent studies were included from the searches. The results of all eight studies indicated changes in acoustic measures, listener perceptions, and self-perceptions following therapeutic intervention for participants of varying ages and backgrounds.Voice and communication interventions appear to improve quality of life, vocal function, and social participation in transgender and non-binary individuals and support movements of acoustic and perceptual measures to more closely reflect an individual's gender. Further, much larger studies are required to (1) compare modes and models of intervention and to (2) assess the efficacy of therapeutic intervention for wider transgender populations.
rights: Copyright © 2025 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
has PII: S0892-1997(25)00015-3
doi: 10.1016/j.jvoice.2025.01.014
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Lorimer G
      type: Person
      first name: G
      last name: Lorimer
      member of: Department of Health Sciences, University of Sheffield, Sheffield, UK. Electronic address: learntosingleicestershire@gmail.com.
  slot:
    index: 2
    item: Rutter B
      type: Person
      first name: B
      last name: Rutter
      member of: Department of Health Sciences, University of Sheffield, Sheffield, UK.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T21:59
e ISSN: 1873-4588
has issn l: 0892-1997
has NLM journal title abbreviation: J Voice
publication name: Journal of voice : official journal of the Voice Foundation
language: eng
has national library of medicine journal id: 8712262
derived from: NLM
has place of publication: United States
source: J Voice. 2025-02-13;():.

Comparison of Deep Learning Models for Voice Disorder Classification Using Kymographic Images.
pmid: 39947969
abstract: Voice is a critical tool for communication, and diagnosing voice disorders poses significant challenges, particularly when using high-speed video (HSV) endoscopy. The primary difficulty with HSV lies in the need for clinical experts to manually analyze and interpret large volumes of HSV frames. To address these challenges, kymography has been introduced as an effective clinical decision-support tool. In this study, a deep learning-based approach for classifying kymographic images is proposed to automate the analysis by training models to detect subtle and intricate variations in pathological vibratory patterns. We used high-speed recordings from the Benchmark for Automatic Glottis Segmentation (BAGLS) dataset to generate kymographic images, which were then used for binary and tertiary classifications employing deep learning models. We evaluated the performance of five widely used pretrained models: AlexNet, DenseNet121, Xception, Inceptionv3, and ResNet50v2. Our experimental results demonstrate that DenseNet121 can automatically classify voice disorders with higher accuracy and better performance across different model evaluation indicators, outperforming existing methods. With further research, the deep learning classifier has the potential to become a valuable diagnostic assistance tool for clinicians.
rights: Copyright © 2025 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
has PII: S0892-1997(25)00001-3
doi: 10.1016/j.jvoice.2025.01.001
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Panchami B
      type: Person
      first name: B
      last name: Panchami
      member of: Department of Biomedical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Tamil Nadu, India. Electronic address: panchamibaskaran@gmail.com.
  slot:
    index: 2
    item: Kumar SP
      type: Person
      first name: S Pravin
      last name: Kumar
      member of: Department of Biomedical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Tamil Nadu, India. Electronic address: pravinkumars@ssn.edu.in.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T21:59
e ISSN: 1873-4588
has issn l: 0892-1997
has NLM journal title abbreviation: J Voice
publication name: Journal of voice : official journal of the Voice Foundation
language: eng
has national library of medicine journal id: 8712262
derived from: NLM
has place of publication: United States
source: J Voice. 2025-02-12;():.

Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture: A register study.
pmid: 39947959
abstract: Acute Achilles tendon rupture (ATR) is a common injury associated with a high rate of deep vein thrombosis (DVT) during rehabilitation. This study assessed whether DVT affects long-term self-reported function.Data from the Danish Achilles Tendon Database were used to compare Achilles tendon Total Rupture Scores (ATRS) at 6, 12, and 24 months between patients with and without symptomatic DVT, adjusting for covariates.No significant ATRS difference between DVT and non-DVT groups was observed over time (adjusted mean difference = -0.7, 95 % CI: -4.8-3.3, p = 0.72). However, patients with DVT reported lower ATRS at 24 months (adjusted mean difference = -4.9, 95 % CI: -9.0 to -0.9, p = 0.02).Symptomatic DVT is not significantly associated with self-reported function over time in patients with ATR. However, patients with DVT may experience a recovery plateau, leading to lower long-term function, though the clinical significance is unclear.
rights: Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
has PII: S1268-7731(25)00033-5
doi: 10.1016/j.fas.2025.02.002
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Gandløse JS
      type: Person
      first name: Jacob S
      last name: Gandløse
      member of: Department of Physiotherapy and Occupational Therapy, Aalborg University Hospital, Aalborg, Denmark; Department of Health Science and Technology, Musculoskeletal Physiotherapy, Aalborg University, Aalborg, Denmark. Electronic address: j.gandloese@rn.dk.
  slot:
    index: 2
    item: Barfod KW
      type: Person
      first name: Kristoffer W
      last name: Barfod
      member of: Section for Sports Traumatology, Department of Orthopedic Surgery, Copenhagen University Hospital Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.
  slot:
    index: 3
    item: Hoeffner R
      type: Person
      first name: Rikke
      last name: Hoeffner
      member of: Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery, and Department of Physical and Occupational Therapy, University Hospital Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.
  slot:
    index: 4
    item: Hansen MS
      type: Person
      first name: Maria Swennergren
      last name: Hansen
      member of: Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Department of Physical and Occupational Therapy and Department of Orthopedic Surgery, Copenhagen University Hospital, Amager and Hvidovre, Copenhagen, Denmark.
  slot:
    index: 5
    item: Christensen M
      type: Person
      first name: Marianne
      last name: Christensen
      member of: Department of Orthopedic Surgery, Department of Physiotherapy and Occupational Therapy, Aalborg University Hospital, Denmark.
  slot:
    index: 6
    item: Riel H
      type: Person
      first name: Henrik
      last name: Riel
      member of: Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-06
dp: 2025 Feb 06
created: 2025-2-13T21:58
e ISSN: 1460-9584
has issn l: 1268-7731
has NLM journal title abbreviation: Foot Ankle Surg
publication name: Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
language: eng
has national library of medicine journal id: 9609647
derived from: NLM
has place of publication: France
source: Foot Ankle Surg. 2025-02-06;():.

Dentate calcifications with palatal tremor and facial myorhythmia in adult-onset cerebral X-linked adrenoleukodystrophy.
pmid: 39947991
abstract: Adrenoleukodystrophy is the most common peroxisomal disorder of beta oxidation with highly complex clinical presentation across different ages of life challenging the diagnostic skills of neurologists. We report a 35-year-male with orbitofrontal lobar dysfunction, spastic paraparesis, cerebellar ataxia and characteristic perioral and palatal tremor with dentate nuclei calcification in imaging.
rights: Copyright © 2025 Elsevier Ltd. All rights reserved.
has PII: S1353-8020(25)00054-9
doi: 10.1016/j.parkreldis.2025.107313
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Sharma R
      type: Person
      first name: Riya
      last name: Sharma
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: riya.090501@gmail.com.
  slot:
    index: 2
    item: Teja CVS
      type: Person
      first name: C V Sai
      last name: Teja
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: nandusaiteja8@gmail.com.
  slot:
    index: 3
    item: Nayan A
      type: Person
      first name: Aditya
      last name: Nayan
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: dr.adityanayan@icloud.com.
  slot:
    index: 4
    item: Goyal MK
      type: Person
      first name: Manoj K
      last name: Goyal
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: goyal_mk@yahoo.com.
  slot:
    index: 5
    item: Mahesh KV
      type: Person
      first name: Karthik V
      last name: Mahesh
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: skarthikvm@gmail.com.
  slot:
    index: 6
    item: Shree R
      type: Person
      first name: Ritu
      last name: Shree
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: ritushree18@gmail.com.
  slot:
    index: 7
    item: Ahuja CK
      type: Person
      first name: Chirag K
      last name: Ahuja
      member of: Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, 160012, India. Electronic address: chiragkahuja@gmail.com.
  slot:
    index: 8
    item: Modi M
      type: Person
      first name: Manish
      last name: Modi
      member of: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, (PGIMER), 160012, India. Electronic address: modipgi@gmail.com.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-09
dp: 2025 Feb 09
created: 2025-2-13T22:00
e ISSN: 1873-5126
has issn l: 1353-8020
has NLM journal title abbreviation: Parkinsonism Relat Disord
publication name: Parkinsonism & related disorders
language: eng
has national library of medicine journal id: 9513583
derived from: NLM
pg: 107313
has place of publication: England
source: Parkinsonism Relat Disord. 2025-02-09;():107313.

Handgrip strength is probably not a predictor of mortality in patients with cardiovascular disease.
pmid: 39947983
has PII: S0929-6646(25)00048-8
doi: 10.1016/j.jfma.2025.02.006
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Finsterer J
      type: Person
      first name: Josef
      last name: Finsterer
      member of: Neurology & Neurophysiology Censer, Vienna, Austria. Electronic address: fifigs1@yahoo.de.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T22:00
ISSN: 0929-6646
has issn l: 0929-6646
has NLM journal title abbreviation: J Formos Med Assoc
publication name: Journal of the Formosan Medical Association = Taiwan yi zhi
language: eng
has national library of medicine journal id: 9214933
derived from: NLM
has place of publication: Singapore
source: J Formos Med Assoc. 2025-02-12;():.

[Hematologic malignancies of the breast].
pmid: 39947994
abstract: Hematolymphoid tumors of the breast are uncommon. They either represent a secondary site of a known hematological malignancy or a primary disease (sometimes linked to systemic treatment such as chemotherapy for other cancers). The majority of primary breast lymphomas are B-cell lymphomas, with diffuse large B-cell lymphoma being the most prevalent. T-cell lymphomas (potentially associated with certain breast implants), plasmacytomas, and myeloid sarcomas have also been reported. The prognosis and treatment depend on the specific type of hematolymphoid neoplasm. It is crucial to identify the hematolymphoid nature of a breast lesion on biopsy to ensure appropriate management and avoid unnecessary surgeries. This situation is a classic challenge due to its rarity, and the pathologists should consider it when dealing with any malignant breast lesion with a triple-negative phenotype.
rights: Copyright © 2025 Elsevier Masson SAS. All rights reserved.
has PII: S0242-6498(25)00014-8
doi: 10.1016/j.annpat.2025.01.014
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: El Khoury L
      type: Person
      first name: Léa
      last name: El Khoury
      member of: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus, 94805 Villejuif, France. Electronic address: Lea.EL-KHOURY@gustaveroussy.fr.
  slot:
    index: 2
    item: Dartigues P
      type: Person
      first name: Peggy
      last name: Dartigues
      member of: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus, 94805 Villejuif, France.
  slot:
    index: 3
    item: Joyon N
      type: Person
      first name: Natacha
      last name: Joyon
      member of: Service de pathologie morphologique, département de biologie et pathologie médicales, Gustave-Roussy Cancer Campus, 94805 Villejuif, France.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T22:00
ISSN: 0242-6498
has issn l: 0242-6498
has NLM journal title abbreviation: Ann Pathol
publication name: Annales de pathologie
language: fre
has national library of medicine journal id: 8106337
derived from: NLM
has place of publication: France
source: Ann Pathol. 2025-02-12;():.

Advancing plant gene activation with CRISPR-Act3.0.
pmid: 39948006
abstract: The pioneering plant genome-engineering tool CRISPR-Act3.0 is promising for precise gene activation, but faces challenges, such as unstable structures and inconsistent gene activation in polyploid genomes. Here, we propose strategic modifications to render CRISPR-Act3.0 more resilient and adaptable, especially in complex plant genomes, where conventional methods have struggled.
rights: Copyright © 2025 Elsevier Ltd. All rights reserved.
has PII: S0167-7799(25)00008-3
doi: 10.1016/j.tibtech.2025.01.008
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Movahedi A
      type: Person
      first name: Ali
      last name: Movahedi
      member of: State Key Laboratory of Tree Genetics and Breeding, College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China; College of Arts and Sciences, Arlington International University, Wilmington, DE 19804, USA.
  slot:
    index: 2
    item: Mu Z
      type: Person
      first name: Zhiying
      last name: Mu
      member of: State Key Laboratory of Tree Genetics and Breeding, College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China.
  slot:
    index: 3
    item: Yang L
      type: Person
      first name: Liming
      last name: Yang
      member of: State Key Laboratory of Tree Genetics and Breeding, College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China. Electronic address: yangliming@njfu.edu.cn.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T22:00
e ISSN: 1879-3096
has issn l: 0167-7799
has NLM journal title abbreviation: Trends Biotechnol
publication name: Trends in biotechnology
language: eng
has national library of medicine journal id: 8310903
derived from: NLM
has place of publication: England
source: Trends Biotechnol. 2025-02-12;():.

Hand function and quality of life with a 3D-printed prosthesis: A case report.
pmid: 39948016
abstract: People throughout the world have amputations but cannot obtain prosthetic devices. 3D-printing can be a cost-effective tool to create prostheses.The study's purpose is to examine the impact that a 3D-printed prosthetic hand has on function and quality of life.This case report collected data from a single subject.For function and quality of life, the Orthotics Prosthetics Users Surveys (OPUS) Upper Extremity Functional Status (UEFS) and the OPUS Health-Related Quality of Life Index (HRQOL) were completed before and after receiving a 3D-printed prosthetic hand.The UEFS pre-test score was 31, while post-test was 50. This 19-point difference exceeds the minimal detectable change (MDC) of 14.8, denoting a positive change. The HRQOL pre-test score was 58 and the post-test was 61. Since the MDC for this survey is 7.4, there is no substantial improvement.Function improved for this participant by nearly two standard deviations, while quality of life was maintained. 3D-printing is a viable, adaptable, and cost-effective alternative that aided the participant's function. This technology in the clinic can meet unique client needs when considering financial limitations or multiple prostheses for growing children.
rights: Copyright © 2025 Elsevier Inc. All rights reserved.
has PII: S0894-1130(24)00171-6
doi: 10.1016/j.jht.2024.12.004
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Rossi R
      type: Person
      first name: Regina
      last name: Rossi
      member of: Department of Occupational Therapy, Alvernia University, Reading, PA, USA. Electronic address: Regina.Rossi@alvernia.edu.
  slot:
    index: 2
    item: Chown G
      type: Person
      first name: Gregory
      last name: Chown
      member of: Department of Occupational Therapy, Alvernia University, Reading, PA, USA.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T22:01
e ISSN: 1545-004X
has issn l: 0894-1130
has NLM journal title abbreviation: J Hand Ther
publication name: Journal of hand therapy : official journal of the American Society of Hand Therapists
language: eng
has national library of medicine journal id: 8806591
derived from: NLM
has place of publication: United States
source: J Hand Ther. 2025-02-12;():.

Finger flexor tendon injuries repaired surgically followed by an early active motion program: A prospective cohort study of clinician- and patient-reported outcomes.
pmid: 39948017
abstract: Finger flexor tendon injuries are usually surgically repaired followed by early active motion rehabilitation. Studies have focussed on clinician-reported outcomes after these injuries.To measure clinician- and patient-reported outcomes after finger flexor tendon repair.Prospective cohort study.Adult patients with traumatic, finger flexor tendon injuries who underwent surgical repair were recruited. An individualized, early active motion rehabilitation program was provided, including an orthosis, progressive active/passive range of motion (ROM) and strengthening exercises. Clinician-reported outcomes, namely total active motion (TAM), Strickland-Glogovac ROM, flexor/extensor deficits, and grip strength, were recorded 3 months post-injury. Patient-reported outcomes, namely the Michigan Hand Questionnaire (MHQ) and 36-item Short Form Health Survey (SF-36), were measured at baseline (pre-injury) and 3 months, and return to work/leisure and level of adherence at 3 months.Data from 32 participants (20 male, mean age 39.8 years, 61 repaired tendons) were analyzed. At 3 months post-injury, mean ROM was 83.5% and 73.8%, compared to the unaffected hand, for total active motion and Strickland-Glogovac ROM, respectively, and grip strength 68.4%. All MHQ scores were statistically significantly worse at 3 months compared to pre-injury (p ≤ 0.012), as were the physical role limitations and physical component summary scores of the SF-36 (p ≤ 0.023). All participants (100.0%) had returned to work by 3 months, and virtually all (96.6%) to leisure activities, although not always at pre-injury levels. The number of digits involved statistically significantly affected Strickland-Glogovac ROM (p ≤ 0.049), flexor deficit (p = 0.042) and SF-36 summary and total scores (p ≤ 0.049). The number of tendons involved statistically significantly affected flexor deficit (p = 0.042). Participant's adherence statistically significantly affected MHQ total score (p = 0.028).The use of patient-reported[cell cut: 2151 characters, first 2000 kept]
rights: Copyright © 2025 Elsevier Inc. All rights reserved.
has PII: S0894-1130(24)00178-9
doi: 10.1016/j.jht.2024.12.011
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Williams N
      type: Person
      first name: Nicola
      last name: Williams
      member of: Physiotherapy, Central Adelaide Local Health Network, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Electronic address: Nicola.Williams@sa.gov.au.
  slot:
    index: 2
    item: Carey M
      type: Person
      first name: Madelaine
      last name: Carey
      member of: Physiotherapy, Central Adelaide Local Health Network, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  slot:
    index: 3
    item: Stiller K
      type: Person
      first name: Kathy
      last name: Stiller
      member of: Allied Health, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-13T22:01
e ISSN: 1545-004X
has issn l: 0894-1130
has NLM journal title abbreviation: J Hand Ther
publication name: Journal of hand therapy : official journal of the American Society of Hand Therapists
language: eng
has national library of medicine journal id: 8806591
derived from: NLM
has place of publication: United States
source: J Hand Ther. 2025-02-12;():.

Quantitative proteomics identifies possible flow of metastatic cues between progressive stages of colorectal cancer via transfer of ceramide-dependent exosomal cargoes.
pmid: 39948040
abstract: Cancer metastasis is largely influenced by cell-cell communication, to which exosomes play a vital role. Exosomes are small extracellular vesicles (sEVs) that originate as intraluminal vesicles (ILVs) within multivesicular bodies (MVBs) during endosome maturation. ILV formation depends on several pathways, including that of ceramide synthesis by neutral sphingomyelinase 2 [nSMase2]. Colorectal cancer (CRC)-derived sEVs are reported to carry a diverse range of metastatic cargo proteins; however, segregation of them in the ceramide-dependent sEV pool (sEVCer) remains unexplored. The current study aimed to identify the metastatic proteins that are secreted through sEVCer, from CRC cells of variable metastatic potentials. Primary (SW480) and metastatic (SW620) CRC cells were treated with nSMase2 blocker and sEVs were isolated, followed by extraction of the sEV proteins for a quantitative proteomic profiling using isobaric tags for relative and absolute quantitation (iTRAQ). In total, 1781 proteins were identified with unused protein score > 1.3. Of these identified proteins, 22.8% and 17.01% were found to be depleted within sEVs of the treated SW480 and SW620 cells, respectively. These depleted protein pools represented the cargo that are preferentially secreted through sEVCer in respective cell types (CargoCer-SW480 and CargoCer-SW620). CargoCer-SW480 overrepresented integrin signaling pathway members and CargoCer-SW620 overrepresented integrin as well as platelet-derived growth factor (PDGF) signaling pathway members. Interestingly, the uniquely overrepresented CargoCer-SW480 and CargoCer-SW620 were biologically connected, rendering possible transfer of metastatic cues via sEVCer. Overall, this study identified CargoCer and their dynamics over progressive CRC stages, and thereby opens up a new research direction for exploring the flow of metastatic cues through uptake and release of sEVCer.
rights: © 2025 Federation of European Biochemical Societies.
doi: 10.1111/febs.17410
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ghosh D
      type: Person
      first name: Dipanjana
      last name: Ghosh
      member of: School of Biomolecular Engineering and Biotechnology, Rajiv Gandhi Technical University, Bhopal, India.Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
  slot:
    index: 2
    item: Lim TK
      type: Person
      first name: Teck Kwang
      last name: Lim
      member of: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
  slot:
    index: 3
    item: Basu A
      type: Person
      first name: Anindya
      last name: Basu
      member of: School of Biomolecular Engineering and Biotechnology, Rajiv Gandhi Technical University, Bhopal, India.School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Bhopal, India.
  slot:
    index: 4
    item: Gross JC
      type: Person
      first name: Julia Christina
      last name: Gross
      member of: Department of Medicine, Institute for Molecular Medicine, HMU Health and Medical University Potsdam, Germany.
  slot:
    index: 5
    item: Lin Q
      type: Person
      first name: Qingsong
      last name: Lin
      member of: Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T22:43
e ISSN: 1742-4658
has issn l: 1742-464X
has NLM journal title abbreviation: FEBS J
publication name: The FEBS journal
language: eng
has national library of medicine journal id: 101229646
derived from: NLM
has place of publication: England
source: FEBS J. 2025-02-13;():.

circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose-derived stem cells via the hsa-miR-647/SOX9 pathway.
pmid: 39948045
abstract: Human adipose-derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair. However, the mechanism of hADSC chondrogenic differentiation is still unclear. This study identifies a novel circRNA, circNR3C2, which is significantly upregulated during the chondrogenic differentiation of hADSCs.To analyze their role in hADSC chondrogenic differentiation, hADSCs were separated and identified by flow cytometry. Thereafter, we conducted Alcian Blue staining to assess chondrogenic differentiation levels. Additionally, RT-qPCR was carried out to detect levels of the cartilage-related genes COL2, Aggrecan and SOX9. Moreover, overlapping target SOX9 and circNR3C2 miRNAs were detected by bioinformatics and luciferase analyses. Finally, the role of circNR3C2 was confirmed in vivo using animal models.We confirmed that the cell surface receptors CD44, CD90 and CD105 were positively expressed on hADSCs, and their cartilage differentiation levels dramatically increased after 2 weeks. Expression of the cartilage-related genes COL2 and Aggrecan and circNR3C2 also markedly increased. CircNR3C2 overexpression enhanced cartilage differentiation of hADSCs, while up-regulating COL2, SOX9 and Aggrecan. Bioinformatics analysis identified hsa-miR-647 as the target miRNA of circNR3C2 and SOX9. Hsa-miR-647 overexpression in hADSCs can antagonize the effect of circNR3C2 on chondrogenic differentiation, and reverse its effect on regulating the expression of COL2, Aggrecan, and SOX9. We also showed that hADSCs overexpressing circNR3C2 promote cartilage repair in vivo.We show that circNR3C2 modulates SOX9 expression to promote hsa-miR-647-mediated hADSC chondrogenic differentiation; targeting circNR3C2 may help to develop new treatments to manage cartilage-related disorders.
rights: © 2025 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.
doi: 10.1002/ame2.12561
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Hou D
      type: Person
      first name: Dabiao
      last name: Hou
      member of: Department of Bone and Joint Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.Department of Orthopedics, Guangzhou Hospital of Integrated Traditional and Western Medicine, The Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  slot:
    index: 2
    item: Wang H
      type: Person
      first name: Huajun
      last name: Wang
      member of: Department of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
  slot:
    index: 3
    item: Guo H
      type: Person
      first name: Hao
      last name: Guo
      member of: Department of Orthopedics, Guangzhou Hospital of Integrated Traditional and Western Medicine, The Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  slot:
    index: 4
    item: Luo D
      type: Person
      first name: Dongbin
      last name: Luo
      member of: Department of Orthopedics, Guangzhou Hospital of Integrated Traditional and Western Medicine, The Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  slot:
    index: 5
    item: Zheng X
      type: Person
      first name: Xiaofei
      last name: Zheng
      member of: Department of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
  slot:
    index: 6
    item: Luo S
      type: Person
      first name: Simin
      last name: Luo
      member of: Department of Bone and Joint Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T22:53
e ISSN: 2576-2095
has issn l: 2576-2095
has NLM journal title abbreviation: Animal Model Exp Med
publication name: Animal models and experimental medicine
language: eng
has national library of medicine journal id: 101726292
derived from: NLM
has place of publication: United States
source: Animal Model Exp Med. 2025-02-13;():.

Genome-Wide Association Study Elucidates the Genetic Architecture of Manganese Tolerance in Brassica napus.
pmid: 39948049
abstract: Brassica napus (canola) is a significant contributor to the world's oil production and is cultivated across continents, yet acidic soils with aluminium (Al3+) and manganese (Mn2+) toxicities limit its production. The genetic determinants underlying natural variation for acidic soil tolerance in canola are unknown and need to be determined. Through genome-wide association analysis of 326 canola accessions, we identified three QTLs for tolerance to Mn2+ toxicity on chromosomes A09, C03, and C09. Allelism tests between four tolerance sources confirmed that at least one locus on A09 controls Mn2+ tolerance in canola. Integrated analyses of genomic and expression QTL and Mn2+ tolerance data revealed that BnMTP8.A09, possibly in conjunction with BnMATE.C03, BnMTP8.C04 and BnMTP8.C08, play a central role in conferring Mn2+ tolerance in canola. Gene expression analysis showed that variation in BnMTP8.A09 expression could account for upto 74% of the variation in Mn2+ tolerance between individuals with extreme phenotypes. Yeast complementation assays and ectopic expression in Arabidopsis show that BnMTP8.A09 can complement manganese-hypersensitive yeast mutant strain PMR1∆ and Arabidopsis atmtp8 mutant background, respectively and restore Mn2+ tolerance to wild-type levels. Our multi-omics research approach unveils the genetic architecture of Mn2+ tolerance and identifies BnMTP8.A09 as a causal gene imparting tolerance to Mn2+ toxicity in canola.
rights: © 2025 The Author(s). Plant, Cell & Environment published by John Wiley & Sons Ltd.
doi: 10.1111/pce.15433
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Raman H
      type: Person
      first name: Harsh
      last name: Raman
      member of: New South Wales Department of Primary Industries and Regional Development, Wagga Wagga Agricultural Institute, Wagga Wagga, Australia.
  slot:
    index: 2
    item: Bai Z
      type: Person
      first name: Zetao
      last name: Bai
      member of: The Key Laboratory of Biology and Genetic Improvement of Oil Crops, the Ministry of Agriculture of PRC, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, Hubei, China.
  slot:
    index: 3
    item: McVittie B
      type: Person
      first name: Brett
      last name: McVittie
      member of: New South Wales Department of Primary Industries and Regional Development, Wagga Wagga Agricultural Institute, Wagga Wagga, Australia.
  slot:
    index: 4
    item: Mukherjee S
      type: Person
      first name: Sourav
      last name: Mukherjee
      member of: Monash University, Clayton, Australia.
  slot:
    index: 5
    item: Goold HD
      type: Person
      first name: Hugh D
      last name: Goold
      member of: New South Wales Department of Primary Industries and Regional Development, Elizabeth Macarthur Agricultural Institute, Menangle, Australia.School of Natural Sciences, Macquarie University, Sydney, Australia.
  slot:
    index: 6
    item: Zhang Y
      type: Person
      first name: Yuanyuan
      last name: Zhang
      member of: The Key Laboratory of Biology and Genetic Improvement of Oil Crops, the Ministry of Agriculture of PRC, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, Hubei, China.
  slot:
    index: 7
    item: Khin NC
      type: Person
      first name: Nay Chi
      last name: Khin
      member of: New South Wales Department of Primary Industries and Regional Development, Wagga Wagga Agricultural Institute, Wagga Wagga, Australia.ARC Training Centre for Future Crops Development, Research School of Biology, Australian National University, Canberra, Australia.
  slot:
    index: 8
    item: Qiu Y
      type: Person
      first name: Yu
      last name: Qiu
      member of: New South Wales Department of Primary Industries and Regional Development, Wagga Wagga Agricultural Institute, Wagga Wagga, Australia.
  slot:
    index: 9
    item: Shamaya N
      type: Person
      first name: Nawar
      last name: Shamaya
      member of: New South Wales Department of Primary Industries and Regional Development, Wagga Wagga Agricultural Institute, Wagga Wagga, Australia.
  slot:
    index: 10
    item: Liu S
      type: Person
      first name: Shengyi
      last name: Liu
      member of: The Key Laboratory of Biology and Genetic Improvement of Oil Crops, the Ministry of Agriculture of PRC, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, Hubei, China.
  slot:
    index: 11
    item: Delourme R
      type: Person
      first name: Regine
      last name: Delourme
      member of: INRA, Agrocampus Ouest, Université de Rennes 1, UMR1349 Institut de Génétique, Environnement et de Protection des Plantes, Le Rheu, France.
  slot:
    index: 12
    item: Pogson BJ
      type: Person
      first name: Barry J
      last name: Pogson
      member of: ARC Training Centre for Future Crops Development, Research School of Biology, Australian National University, Canberra, Australia.
  slot:
    index: 13
    item: Balasubramanian S
      type: Person
      first name: Sureshkumar
      last name: Balasubramanian
      member of: Monash University, Clayton, Australia.
  slot:
    index: 14
    item: Raman R
      type: Person
      first name: Rosy
      last name: Raman
      member of: New South Wales Department of Primary Industries and Regional Development, Wagga Wagga Agricultural Institute, Wagga Wagga, Australia.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T22:53
e ISSN: 1365-3040
has issn l: 0140-7791
has NLM journal title abbreviation: Plant Cell Environ
publication name: Plant, cell & environment
language: eng
has national library of medicine journal id: 9309004
derived from: NLM
has place of publication: United States
source: Plant Cell Environ. 2025-02-13;():.

ACCEPT Group Condensed Position Paper on the Management of Recurrent Pregnancy Loss.
pmid: 39948053
abstract: The Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial Evidence (ACCEPT) group recently published an evidence-based guideline on the investigation and management of recurrent pregnancy loss (RPL). This position paper is a brief summary of the freely accessible two-part guideline and can be found with digital object identifier (DOI) 10.1111/ajo.13821 and DOI 10.1111/ajo.13820.
rights: © 2025 The Author(s). Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
doi: 10.1111/ajo.70001
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Suker A
      type: Person
      first name: Adriana
      last name: Suker
      member of: Department of Obstetrics & Gynaecology, Liverpool Hospital, Sydney, New South Wales, Australia.Reproductive Endocrinology & Infertility, Advanced Endoscopic Gynaecology & Obstetrics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
  slot:
    index: 2
    item: Li Y
      type: Person
      first name: Ying
      last name: Li
      member of: Reproductive Endocrinology & Infertility, Advanced Endoscopic Gynaecology & Obstetrics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
  slot:
    index: 3
    item: Marren A
      type: Person
      first name: Anthony
      last name: Marren
      member of: Reproductive Endocrinology & Infertility, Advanced Endoscopic Gynaecology & Obstetrics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
  slot:
    index: 4
    item: Robson D
      type: Person
      first name: Danielle
      last name: Robson
      member of: Reproductive Endocrinology & Infertility, Advanced Endoscopic Gynaecology & Obstetrics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
creator: Australasian CREI (Certificate of Reproductive Endocrinology and Infertility) Consensus Expert Panel on Trial evidence (ACCEPT) Group
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:02
e ISSN: 1479-828X
has issn l: 0004-8666
has NLM journal title abbreviation: Aust N Z J Obstet Gynaecol
publication name: The Australian & New Zealand journal of obstetrics & gynaecology
language: eng
has national library of medicine journal id: 0001027
derived from: NLM
has place of publication: Australia
source: Aust N Z J Obstet Gynaecol. 2025-02-13;():.

Emergence of a New Threat in East Asia: Severe Agitation and Suicide Attempts Linked to Etomidate-Infused E-Cigarettes.
pmid: 39948057
doi: 10.1111/appy.70001
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Liu CI
      type: Person
      first name: Chun-I
      last name: Liu
      member of: Department of Psychiatry, National Taiwan University Hospital, Taipei City, Taiwan.
  slot:
    index: 2
    item: Chen IM
      type: Person
      first name: I-Ming
      last name: Chen
      member of: Department of Psychiatry, National Taiwan University Hospital, Taipei City, Taiwan.
  slot:
    index: 3
    item: Wang SY
      type: Person
      first name: Szu-Yung
      last name: Wang
      member of: Department of Psychiatry, National Taiwan University Hospital, Taipei City, Taiwan.
  slot:
    index: 4
    item: Chen C
      type: Person
      first name: Chi
      last name: Chen
      member of: Department of Addiction Sciences, Taipei City Psychiatric Center, Taipei City Hospital, Taipei City, Taiwan.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-03
dp: 2025 Mar
created: 2025-2-13T23:03
e ISSN: 1758-5872
has issn l: 1758-5864
issue: 1
has NLM journal title abbreviation: Asia Pac Psychiatry
publication name: Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
language: eng
has national library of medicine journal id: 101506757
derived from: NLM
pg: e70001
has place of publication: Australia
source: Asia Pac Psychiatry. 2025-03;17(1):e70001.
volume: 17

Assessment of Oncology Nurses' and Physicians' Attitudes Toward Death and End-of-Life Care, Along With Contributing Factors: A Cross-Sectional Study.
pmid: 39948058
abstract: Background: Providing care for terminally ill patients presents a complex challenge for nurses and physicians, often leading to psychological concerns and significant physical and emotional distress for patients, their families, and healthcare providers. The intricacies of managing end-of-life care can evoke a range of feelings, including fear, anxiety, and sadness, which can affect the quality of care delivered. Understanding these dynamics is essential for improving the support systems for both healthcare professionals and patients during this critical time. Aim: This study aimed to evaluate the attitudes toward death and end-of-life care among nurses and physicians and to investigate whether these attitudes are influenced by specific demographic characteristics, including gender, years of experience, previous education on death and dying, previous experience in dealing with terminally ill persons, previous experience with loss, present experience with loss, and the influence of religious beliefs. By examining these attitudes, the research seeks to identify potential areas for intervention and education that could enhance the overall approach to end-of-life care in oncology settings. Method: A total of 200 oncology nurses and physicians were recruited through a non-probability convenience sampling method from a specialized oncology hospital in Jordan. Participants were asked to complete a comprehensive questionnaire that included a demographic data sheet and Frommelt's Attitude Toward Care of the Dying - B scale. This scale is designed to measure attitudes toward caring for dying patients, providing valuable insights into the perspectives of healthcare professionals in this challenging field. Results: The findings indicated that the majority of nurses and physicians held a positive attitude toward death (FATCOD = 106.31), suggesting a general comfort with the concept of death and the process of dying. Additionally, statistically significant correlations were found[cell cut: 3537 characters, first 2000 kept]
doi: 10.1177/00302228251320685
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Alhusamiah B
      type: Person
      first name: Bushra
      last name: Alhusamiah
      member of: Faculty of Nursing, Middle East University, Amman, Jordan.
  slot:
    index: 2
    item: Zeilani RS
      type: Person
      first name: Ruqayya S
      last name: Zeilani
      member of: School of Nursing, The University of Jordan, Amman, Jordan.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:03
e ISSN: 1541-3764
has issn l: 0030-2228
has NLM journal title abbreviation: Omega (Westport)
publication name: Omega
language: eng
has national library of medicine journal id: 1272106
derived from: NLM
pg: 302228251320685
has place of publication: United States
source: Omega (Westport). 2025-02-13;():302228251320685.

Patient safety as a measure of resilience in US hospitals: central line-associated bloodstream infections, July 2020 through June 2021.
pmid: 39948082
abstract: Resilience of the healthcare system has been described as the ability to absorb, adapt, and respond to stress while maintaining the provision of safe patient care. We quantified the impact that stressors associated with the COVID-19 pandemic had on patient safety, as measured by central line-associated bloodstream infections (CLABSIs) reported to the Centers for Disease Control and Prevention's National Healthcare Safety Network.Acute care hospitals were mandated to report markers of resource availability (staffing and hospital occupancy with COVID-19 inpatients) to the federal government between July 2020 and June 2021. These data were used with community levels of COVID-19 to develop a statistical model to assess factors influencing rates of CLABSIs among inpatients during the pandemic.After risk adjustment for hospital characteristics, measured stressors were associated with increased CLABSIs. Staff shortages for more than 10% of days per month were associated with a statistically significant increase of 2 CLABSIs per 10,000 central line days versus hospitals reporting staff shortages of less than 10% of days per month. CLABSIs increased with a higher inpatient COVID-19 occupancy rate; when COVID-19 occupancy was 20% or more, there were 5 more CLABSIs per 10,000 central line days versus the referent (less than 5%).Reporting of data pertaining to hospital operations during the COVID-19 pandemic afforded an opportunity to evaluate resilience of US hospitals. We demonstrate how the stressors of staffing shortages and high numbers of patients with COVID-19 negatively impacted patient safety, demonstrating poor resilience. Understanding stress in hospitals may allow for the development of policies that support resilience and drive safe care.
has PII: S0899823X24001673
doi: 10.1017/ice.2024.167
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Sapiano MRP
      type: Person
      first name: Mathew R P
      last name: Sapiano
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.Lantana Consulting, East Thetford, VT, USA.
  slot:
    index: 2
    item: Dudeck MA
      type: Person
      first name: Margaret A
      last name: Dudeck
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 3
    item: Patel PR
      type: Person
      first name: Prachi R
      last name: Patel
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.CACI, Atlanta, GA, USA.
  slot:
    index: 4
    item: Binder AM
      type: Person
      first name: Alison M
      last name: Binder
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 5
    item: Kofman A
      type: Person
      first name: Aaron
      last name: Kofman
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 6
    item: Kuhar DT
      type: Person
      first name: David T
      last name: Kuhar
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 7
    item: Pillai SK
      type: Person
      first name: Satish K
      last name: Pillai
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 8
    item: Stuckey MJ
      type: Person
      first name: Matthew J
      last name: Stuckey
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 9
    item: Edwards JR
      type: Person
      first name: Jonathan R
      last name: Edwards
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  slot:
    index: 10
    item: Benin AL
      type: Person
      first name: Andrea L
      last name: Benin
      member of: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:15
e ISSN: 1559-6834
has issn l: 0899-823X
has NLM journal title abbreviation: Infect Control Hosp Epidemiol
publication name: Infection control and hospital epidemiology
language: eng
has national library of medicine journal id: 8804099
derived from: NLM
starting page: 1
ending page: 7
has place of publication: United States
source: Infect Control Hosp Epidemiol. 2025-02-14;():1-7.

Osteoarthritis.
pmid: 39948112
has PII: 10.1038/s41572-025-00598-2
doi: 10.1038/s41572-025-00598-2
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:17
e ISSN: 2056-676X
has issn l: 2056-676X
issue: 1
has NLM journal title abbreviation: Nat Rev Dis Primers
publication name: Nature reviews. Disease primers
language: eng
has national library of medicine journal id: 101672103
derived from: NLM
pg: 11
has place of publication: England
source: Nat Rev Dis Primers. 2025-02-13;11(1):11.
volume: 11

Evaluating ChatGPT's role in urological counseling and clinical decision support.
pmid: 39948169
has PII: 10.1007/s00345-025-05500-z
doi: 10.1007/s00345-025-05500-z
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Malshy K
      type: Person
      first name: Kamil
      last name: Malshy
      member of: Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 668, Rochester, NY, 14642, USA. kamilmalshy@gmail.com.
  slot:
    index: 2
    item: Bandari J
      type: Person
      first name: Jathin
      last name: Bandari
      member of: Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 668, Rochester, NY, 14642, USA.
  slot:
    index: 3
    item: Kucherov V
      type: Person
      first name: Victor
      last name: Kucherov
      member of: Pediatric Urology- Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 4
    item: Joseph JV
      type: Person
      first name: Jean V
      last name: Joseph
      member of: Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 668, Rochester, NY, 14642, USA.
  slot:
    index: 5
    item: Osinski T
      type: Person
      first name: Thomas
      last name: Osinski
      member of: Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 668, Rochester, NY, 14642, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:20
e ISSN: 1433-8726
has issn l: 0724-4983
issue: 1
has NLM journal title abbreviation: World J Urol
publication name: World journal of urology
language: eng
has national library of medicine journal id: 8307716
derived from: NLM
pg: 121
has place of publication: Germany
source: World J Urol. 2025-02-13;43(1):121.
volume: 43

Social isolation and sarcopenia: the mediating role of physical activity and the intersocietal differences from US and China.
pmid: 39948198
abstract: Little is known about the causal relationship between sarcopenia and social isolation. This study investigated the association between social isolation and sarcopenia and explored the mediating role of physical activity among American and Chinese older adults.Data were from the Health and Retirement Study (HRS) and China Health and Retirement Longitudinal Study (CHARLS), encompassing 3,383 American and 6,996 Chinese. Sarcopenia was defined by the European Working Group on Sarcopenia in Older People 2 and Asian Working Group for Sarcopenia 2019 criteria. Social isolation was measured by the Steptoe Social Isolation Index for American and a 5-item scale for Chinese. Logistic regression models with inverse probability weighting were conducted to explore the effect of social isolation on sarcopenia risk. Causal mediation analysis was conducted to examine direct and indirect associations.Over 8-year and 4-year follow-ups, 363 Americans and 392 Chinese had sarcopenia. Social isolation was associated with higher risk of sarcopenia in HRS (OR = 1.14, 95% CI = 1.02-1.29) and CHARLS (OR = 1.24, 95% CI = 1.10-1.39). The indirect effects of social isolation on sarcopenia through physical activity were significant only in HRS, explaining 7.63% of the total effect. Handgrip strength and gait speed were significantly associated with social isolation for HRS and CHARLS, while muscle mass and chair-stand test performance were significantly associated only in CHARLS.Social isolation significantly increased the risk of sarcopenia. Physical activity partially mediated this association only in Americans. More attention should be paid on socially isolated older adults to prevent sarcopenia.
rights: © 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
has PII: 10.1007/s00127-025-02832-4
doi: 10.1007/s00127-025-02832-4
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Li S
      type: Person
      first name: Sicheng
      last name: Li
      member of: State Key Laboratory of Molecular Vaccine and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen, China.School of Public Health, Xiamen University, Xiang'an South Road, Xiamen, 361102, China.
  slot:
    index: 2
    item: He L
      type: Person
      first name: Lingxiao
      last name: He
      member of: State Key Laboratory of Molecular Vaccine and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen, China.School of Public Health, Xiamen University, Xiang'an South Road, Xiamen, 361102, China.
  slot:
    index: 3
    item: Fang Y
      type: Person
      first name: Ya
      last name: Fang
      member of: State Key Laboratory of Molecular Vaccine and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China. fangya@xmu.edu.cn.Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen, China. fangya@xmu.edu.cn.School of Public Health, Xiamen University, Xiang'an South Road, Xiamen, 361102, China. fangya@xmu.edu.cn.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:22
e ISSN: 1433-9285
has issn l: 0933-7954
has NLM journal title abbreviation: Soc Psychiatry Psychiatr Epidemiol
publication name: Social psychiatry and psychiatric epidemiology
language: eng
has national library of medicine journal id: 8804358
derived from: NLM
has place of publication: Germany
source: Soc Psychiatry Psychiatr Epidemiol. 2025-02-13;():.

Ecological momentary interventions for bipolar disorder: a systematic review and meta-analysis.
pmid: 39948199
abstract: Bipolar Disorders affect 2% of the world population and ranks as the sixth leading cause of disability. Barriers such as lack of insight and limited access to healthcare result in a significant disease burden. These barriers can be mitigated by technology-delivered interventions such as ecological momentary interventions, which provide personalized, real-time treatments based on ecological momentary assessments of relevant variables. This review aimed to assess the effectiveness of ecological momentary interventions in bipolar disorder.We conducted searches across Medline, Scopus, CENTRAL, psychINFO and ProQuest without applying any filter through December 30, 2023. Two authors screened results to eliminate irrelevant and duplicate studies, and the remaining studies were independently reviewed. Data were extracted, transformed into a common rubric, and analyzed for treatment effects using Review Manager 5.We analyzed 14 studies, encompassing 1776 patients with bipolar disorder. Interventions were mostly based on psychoeducation and cognitive behavioral therapy. EMI had small to moderate effects on quality of life (SMD = 0.24; 95% CI = 0.04-0.44, P = 0.02; I² = 47%), medication adherence (SMD = 0.21; 95% CI = 0.03-0.39, P = 0.02; I² = 0%), and affective episodes (HR = 0.75; 95% CI = 0.57-0.98, P = 0.04; I² = 0%).Ecological momentary intervention is a novel area of research in behavioral science. The results of this systematic review based on the available literature suggest that these interventions could be beneficial for patients with bipolar disorder.
rights: © 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
has PII: 10.1007/s00127-025-02845-z
doi: 10.1007/s00127-025-02845-z
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Hirbod-Mobarakeh A
      type: Person
      first name: Armin
      last name: Hirbod-Mobarakeh
      member of: Hirbod Psychiatric and Psychologic Club (BAVAR), Tehran, Iran.Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Keshavarz-Akhlaghi AA
      type: Person
      first name: Amir-Abbas
      last name: Keshavarz-Akhlaghi
      member of: Mental Health Research Center, Department of Psychiatry, School of Medicine, Psychosocial Health Research Institute (PHRI), Iran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Hadi F
      type: Person
      first name: Fatemeh
      last name: Hadi
      member of: Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 4
    item: Eghdami S
      type: Person
      first name: Shayan
      last name: Eghdami
      member of: Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. seghdami33@gmail.com.Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. seghdami33@gmail.com.Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Hemat Highway, Next to Milad Tower, Tehran, 14535, Iran. seghdami33@gmail.com.
  slot:
    index: 5
    item: Hirbod-Mobarakeh A
      type: Person
      first name: Arash
      last name: Hirbod-Mobarakeh
      member of: Hirbod Psychiatric and Psychologic Club (BAVAR), Tehran, Iran.
  slot:
    index: 6
    item: Kalhori SH
      type: Person
      first name: Sara Hassan
      last name: Kalhori
      member of: Hirbod Psychiatric and Psychologic Club (BAVAR), Tehran, Iran.
  slot:
    index: 7
    item: Khanipour-Kencha A
      type: Person
      first name: Ali
      last name: Khanipour-Kencha
      member of: Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:22
e ISSN: 1433-9285
has issn l: 0933-7954
has NLM journal title abbreviation: Soc Psychiatry Psychiatr Epidemiol
publication name: Social psychiatry and psychiatric epidemiology
language: eng
has national library of medicine journal id: 8804358
derived from: NLM
has place of publication: Germany
source: Soc Psychiatry Psychiatr Epidemiol. 2025-02-13;():.

A rifamycin SV in situ gelling formulation for the treatment of pouchitis.
pmid: 39948209
abstract: Procto-colectomy with an ileal pouch anal anastomosis is performed in Ulcerative Colitis patients as a potential curative surgical option. However, in many patients a non-specific inflammation of the ileal reservoir can occur, named pouchitis. Some patients further develop a chronic antibiotic-resistant disease. Rifaximin, an oral, broad-spectrum antibiotic has been shown to have efficacy for some patients. In the present study CB0125, a novel Rifamycin SV in situ gelling formulation, was developed as a potential pouchitis therapy. This mixture undergoes sol to gel transition under physiological pH and temperature upon administration to the target organ by enema. The in vivo efficacy of the in situ gel was performed using dextran sodium sulphate-induced colitis model in C57/Bl6 mice. The clinical parameters such as body weight changes, rectal bleeding and stool consistency were compared to mesalamine (positive control). In addition, a histopathological investigation was conducted to assess severity of mucosal damage and inflammation infiltrate. CB0125 was well tolerated and there was a significant reduction in disease activity, improved colon weight to length ratio, and improved histology score for the CB-01-25 in situ gel group compared to placebo gel. In addition, CB0125 was superior to mesalamine and to rifamycin SV dissolved in water. We propose that the rifamycin SV in situ gel may provide a longer duration of exposure of this dual acting antibiotic / anti-inflammatory drug at the site of the damaged intestinal mucosa resulting in a superior combined effect, relative to rifamycin SV dissolved in water, for the treatment of pouchitis.
rights: © 2025. Controlled Release Society.
has PII: 10.1007/s13346-025-01808-w
doi: 10.1007/s13346-025-01808-w
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Mangano K
      type: Person
      first name: Katia
      last name: Mangano
      member of: Cosmo SpA, Via C. Colombo 1, Lainate, 20045, MI, Italy.
  slot:
    index: 2
    item: Quatrocchi C
      type: Person
      first name: Cinzia
      last name: Quatrocchi
      member of: Cosmo SpA, Via C. Colombo 1, Lainate, 20045, MI, Italy.
  slot:
    index: 3
    item: Ajello K
      type: Person
      first name: Katia
      last name: Ajello
      member of: Cosmo SpA, Via C. Colombo 1, Lainate, 20045, MI, Italy.
  slot:
    index: 4
    item: Pagani S
      type: Person
      first name: Stefania
      last name: Pagani
      member of: Cosmo SpA, Via C. Colombo 1, Lainate, 20045, MI, Italy.
  slot:
    index: 5
    item: Alton G
      type: Person
      first name: Gordon
      last name: Alton
      member of: Cosmobiolabs, 6199 Cornerstone Court E., Suite 101, San Diego, CA, 92121, USA. galton@cosmopharma.com.
  slot:
    index: 6
    item: Longo L
      type: Person
      first name: Luigi
      last name: Longo
      member of: Riverside II Sir John Rogerson's Quay, Dublin 2, San Diego, CA, 92121, USA.
  slot:
    index: 7
    item: Gerloni M
      type: Person
      first name: Mara
      last name: Gerloni
      member of: Riverside II Sir John Rogerson's Quay, Dublin 2, San Diego, CA, 92121, USA.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:22
e ISSN: 2190-3948
has issn l: 2190-393X
has NLM journal title abbreviation: Drug Deliv Transl Res
publication name: Drug delivery and translational research
language: eng
has national library of medicine journal id: 101540061
derived from: NLM
has place of publication: United States
source: Drug Deliv Transl Res. 2025-02-13;():.

Enhancing Adverse Event Reporting With Clinical Language Models: Inpatient Falls.
pmid: 39948219
abstract: To develop a method for computationally detecting fall events using clinical language models to complement existing self-reporting mechanisms.Retrospective observational study.Text data were collected from the unstructured nursing notes of three hospitals' electronic health records and the Korean national patient safety reports, totalling 34,480 records covering the period from January 2015 to December 2019. Note-level labelling was conducted by two researchers with 95% agreement. Preprocessing data anonymisation and English translation were followed by semantic validation. Five language models based on pretrained Bidirectional Encoder Representations from Transformers (BERT) and Generative Pretrained Transformer (GPT)-4 with prompt programming were explored. Model performance was assessed using F measurements. Error analysis was conducted for the GPT-4 results.Fine-tuned BERT models with the English data set outperformed GPT-4, with Bio+Clinical BERT achieving the highest F1 score of 0.98. Fine-tuned Korean BERT with the Korean data set also reached an F1 score of 0.98, while GPT-4 achieved a competitive F1 score of 0.94. GPT-4 with prompt programming showed much higher F1 scores than GPT-4 with a standardised prompt for the English data set (0.85 vs. 0.39) and the Korean data set (0.94 vs. 0.03). The error analysis identified that the common misclassification patterns included fall history and homonyms, causing false positives and implicit expressions and missing contextual information, causing false negatives.The clinical language model approach, if used alongside the existing self-reporting, promises to increase the chance of identifying the majority of factual falls without the need for additional chart reviews.Inpatient falls are often underreported, with up to 91% of incidents missed in self-reports. Using language models, we identified a significant portion of these unreported falls, improving the accuracy of adverse event tracking while reducing the self-re[cell cut: 2040 characters, first 2000 kept]
rights: © 2025 The Author(s). Journal of Advanced Nursing published by John Wiley & Sons Ltd.
doi: 10.1111/jan.16812
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Cho I
      type: Person
      first name: Insook
      last name: Cho
      member of: College of Nursing, Inha University, Incheon, Republic of Korea.The Center for Patient Safety Research and Practice, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 2
    item: Park H
      type: Person
      first name: Hyunchul
      last name: Park
      member of: Seoul School of Integrated Science & Technologies, aSSIST University, Seoul, Republic of Korea.Graduate School of Artificial Intelligence, Pohang University of Science and Technology, Gyeongbuk, Republic of Korea.Graduate School of Information & Telecommunications, Konkuk University, Seoul, Republic of Korea.
  slot:
    index: 3
    item: Park BS
      type: Person
      first name: Byeong Sun
      last name: Park
      member of: Department of Electrical and Computer Engineering, Inha University, Incheon, Republic of Korea.
  slot:
    index: 4
    item: Lee DG
      type: Person
      first name: Dong-Geon
      last name: Lee
      member of: Graduate School of Artificial Intelligence, Pohang University of Science and Technology, Gyeongbuk, Republic of Korea.Department of Information and Communication Engineering, Inha University, Incheon, Republic of Korea.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:23
e ISSN: 1365-2648
has issn l: 0309-2402
has NLM journal title abbreviation: J Adv Nurs
publication name: Journal of advanced nursing
language: eng
has national library of medicine journal id: 7609811
derived from: NLM
has place of publication: England
source: J Adv Nurs. 2025-02-13;():.

Analysis of Attitudes Toward Breastfeeding and Spiritual Life During Pregnancy in Türkiye: A Qualitative Study.
pmid: 39948218
abstract: It is crucial for nurses to understand the meaning of spirituality, which can become more pronounced during pregnancy, childbirth, and breastfeeding, and to take a supportive approach to breastfeeding attitudes during pregnancy. This study aimed to explore pregnant women's attitudes and spiritual experiences in Türkiye regarding breastfeeding. A qualitative inductive content analysis design was employed. Seventeen pregnant women (36-39-week gestation) were admitted to a maternity hospital in Zonguldak, Türkiye. They were selected using purposive sampling. Data were collected through semi-structured, face-to-face, in-depth interviews and analyzed using an inductive content analysis approach. The mean age of the participants was 27.41 years, and ten participants were primiparous. Multiparous participants had previously breastfed for a mean duration of 19.1 months. Three main themes emerged: Breastfeeding and life, Spiritual life and breastfeeding, and Cultural synthesis. Considering the impact of spirituality on breastfeeding during pregnancy, these findings may help nurses recognize pregnant women's spiritual needs and value the protective role of spirituality. Understanding these dimensions could improve the quality of support provided by healthcare professionals and potentially enhance breastfeeding outcomes.
rights: © 2025. The Author(s).
has PII: 10.1007/s10943-024-02235-w
doi: 10.1007/s10943-024-02235-w
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Dinçer Y
      type: Person
      first name: Yeliz
      last name: Dinçer
      member of: Department of Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. yelizdincer83@hotmail.com.
  slot:
    index: 2
    item: Erciyas ŞK
      type: Person
      first name: Şeyma Kilci
      last name: Erciyas
      member of: Department of Nursing, Faculty of Health Sciences, Amasya University, Amasya, Turkey.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:23
e ISSN: 1573-6571
has issn l: 0022-4197
has NLM journal title abbreviation: J Relig Health
publication name: Journal of religion and health
language: eng
has national library of medicine journal id: 2985199R
derived from: NLM
has place of publication: United States
source: J Relig Health. 2025-02-13;():.

Delayed rectum perforation by a peritoneal dialysis catheter in a peritoneal dialysis patient: a case report and literature review.
pmid: 39948236
abstract: A 60-year-old woman with diabetic nephropathy was diagnosed with end-stage kidney disease and underwent peritoneal dialysis (PD) (X-3 years). Due to decreased residual renal function, she commenced combined PD and hemodialysis (HD) for 6 h once a week (Jan. X year). Seven months later, she visited her maintenance dialysis facility because of fluid leakage from the pubic region and abdominal pain during the dialysate infusion. Tests of the leakage fluid revealed a high glucose concentration, leading to discontinuation of PD and transfer to HD three times a week. She had been referred to a general hospital in her city, where vesical and uterine fistulas were excluded. Consequently, she was referred to our department to investigate the cause of the leakage. She was diagnosed with peritonitis by a physician and was receiving treatment. The lumen of the PD catheter was brownish, indicating possible contamination, leading us to plan its removal. At the time of catheter removal, laparoscopy and intraoperative lower gastrointestinal endoscopy revealed a rectal perforation at the tip of the PD catheter; this was removed after suturing the damaged area. This was a rare case of delayed perforation of the rectum by a PD catheter, during combined PD and HD therapy.
rights: © 2025. The Author(s), under exclusive licence to Japanese Society of Nephrology.
has PII: 10.1007/s13730-025-00971-w
doi: 10.1007/s13730-025-00971-w
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Iwata M
      type: Person
      first name: Mayu
      last name: Iwata
      member of: Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.Department of Nephrology, Nagasaki Renal Center, Nagasaki, Japan.
  slot:
    index: 2
    item: Uramatsu T
      type: Person
      first name: Tadashi
      last name: Uramatsu
      member of: Department of Nephrology, Nijigaoka Hospital, 1-1 Nijigaoka, Nagasaki, 852-8055, Japan. tadashi.uramatsu@gmail.com.
  slot:
    index: 3
    item: Sakamoto R
      type: Person
      first name: Ryosuke
      last name: Sakamoto
      member of: Department of Nephrology, JCHO Isahaya General Hospital, Nagasaki, Japan.
  slot:
    index: 4
    item: Torigoe K
      type: Person
      first name: Kenta
      last name: Torigoe
      member of: Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.
  slot:
    index: 5
    item: Yamashita A
      type: Person
      first name: Ayuko
      last name: Yamashita
      member of: Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.
  slot:
    index: 6
    item: Abe S
      type: Person
      first name: Shinichi
      last name: Abe
      member of: Department of Nephrology, Nagasaki Renal Center, Nagasaki, Japan.
  slot:
    index: 7
    item: Ota Y
      type: Person
      first name: Yuki
      last name: Ota
      member of: Department of Nephrology, Sasebo City General Hospital, Nagasaki, Japan.
  slot:
    index: 8
    item: Kitamura M
      type: Person
      first name: Mineaki
      last name: Kitamura
      member of: Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.Division of Blood Purification, Nagasaki University Hospital, Nagasaki, Japan.
  slot:
    index: 9
    item: Maeda A
      type: Person
      first name: Atsuhiro
      last name: Maeda
      member of: Department of Nephrology and Dialysis Center, Kouzenkai-Maeda Hospital, Saga, Japan.
  slot:
    index: 10
    item: Mochizuki Y
      type: Person
      first name: Yasushi
      last name: Mochizuki
      member of: Division of Blood Purification, Nagasaki University Hospital, Nagasaki, Japan.Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  slot:
    index: 11
    item: Muta K
      type: Person
      first name: Kumiko
      last name: Muta
      member of: Advanced Medical Education Center, Nagasaki University School of Medicine, Nagasaki, Japan.
  slot:
    index: 12
    item: Imamura R
      type: Person
      first name: Ryoichi
      last name: Imamura
      member of: Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  slot:
    index: 13
    item: Nishino T
      type: Person
      first name: Tomoya
      last name: Nishino
      member of: Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:24
e ISSN: 2192-4449
has issn l: 2192-4449
has NLM journal title abbreviation: CEN Case Rep
publication name: CEN case reports
language: eng
has national library of medicine journal id: 101636244
derived from: NLM
has place of publication: Japan
source: CEN Case Rep. 2025-02-13;():.

Value of Post-NAC CT-based Node-RADS score for Predicting residual lymph node metastasis and survival outcome of locally advanced gastric cancer.
pmid: 39948223
abstract: The Node Reporting and Data System (Node-RADS) provides structured and effective evaluation for lymph nodes in malignancies. This study aims to investigate its value in predicting residual lymph node metastasis (LNM) and survival outcome of locally advanced gastric cancer (LAGC).This retrospective study included 118 patients with LAGC underwent neoadjuvant chemotherapy (NAC) and gastrectomy from April 2015 to June 2020. The diagnostic performance of the post-NAC CT-based Node-RADS score for regional LNM, both at the patient level and at the perigastric/extragastric subgroup level, was estimated using area under receiver operating characteristic curve (AUC) and Youden's index. Kaplan-Meier curve was employed for prognostic analyses between high/low Node-RADS score group. A predictive Node-RADS (NR) model for LNM was developed using logistic regression analyses and a prognostic NR model for overall survival (OS) was developed using Cox regression analyses.In the prediction of LNM, the Node-RADS score exhibited an AUC of 0.843 (95%CI: 0.765-0.921) at patient level, 0.838 (95%CI: 0.757-0.918) in perigastric subgroup and 0.813 (95%CI: 0.724-0.901) in extragastric subgroup, surpassing LN short-axis criteria (AUC:0.664 [95%CI: 0.584-0.743], p < 0.001). The AUC of the NR predictive model for LNM increased to 0.870 (95%CI: 0.795-0.945), with 88.7% sensitivity and 78.9% specificity. The Node-RADS score was significantly correlated with post-NAC pathological status, and served as an independent indicator for OS (all p < 0.05).The NR prognostic model exhibited a Harrell's consistency index (C-index) of 0.724 (95%CI: 0.663-0.785), with no significant difference from the pathological prognostic model (0.739 [95%CI: 0.677-0.801], p = 0.695).The post-NAC Node-RADS score provides accurate prediction of regional LNM and shows promising prognostic value for LAGC patients. Post-NAC Node-RADS related predictive models show potential in early identification of high-risk LAGC patients wit[cell cut: 2051 characters, first 2000 kept]
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s00261-025-04843-w
doi: 10.1007/s00261-025-04843-w
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Sun Y
      type: Person
      first name: Yan
      last name: Sun
      member of: Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, China.Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 2
    item: Xiao H
      type: Person
      first name: Hua
      last name: Xiao
      member of: Department of Hepatobiliary and Intestinal Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.Department of Gastroduodenal and Pancreatic Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 3
    item: Wen L
      type: Person
      first name: Lu
      last name: Wen
      member of: Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 4
    item: Xiang W
      type: Person
      first name: Wang
      last name: Xiang
      member of: Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 5
    item: Luo X
      type: Person
      first name: Xiangtong
      last name: Luo
      member of: Department of Radiotherapy Technology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 6
    item: Yang X
      type: Person
      first name: Xiaohuang
      last name: Yang
      member of: Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 7
    item: Chen L
      type: Person
      first name: Lian
      last name: Chen
      member of: Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 8
    item: Yang Y
      type: Person
      first name: Yanhui
      last name: Yang
      member of: Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, China.Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 9
    item: Zhang Y
      type: Person
      first name: Yi
      last name: Zhang
      member of: Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, China.Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 10
    item: Yu S
      type: Person
      first name: Sanqiang
      last name: Yu
      member of: Norman Bethune Health Science Center of Jilin University, changchun, China.
  slot:
    index: 11
    item: Yu X
      type: Person
      first name: Xiaoping
      last name: Yu
      member of: Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, China. yuxiaoping@hnca.org.cn.Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China. yuxiaoping@hnca.org.cn.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:23
e ISSN: 2366-0058
has NLM journal title abbreviation: Abdom Radiol (NY)
publication name: Abdominal radiology (New York)
language: eng
has national library of medicine journal id: 101674571
derived from: NLM
has place of publication: United States
source: Abdom Radiol (NY). 2025-02-14;():.

Small pancreatic ductal adenocarcinoma (≤ 2 cm): different imaging and clinicopathologic features according to extrapancreatic extension.
pmid: 39948224
abstract: To assess features of small pancreatic ductal adenocarcinoma (s-PDA, ≤ 2 cm) according to extrapancreatic extension (EPE) and predictors for recurrence.This retrospective study included patients diagnosed with s-PDA who underwent surgery between January 2004 and October 2021. Preoperative CT or MRI images were reviewed by two reviewers. Imaging and clinicopathologic features of s-PDA were compared according to the presence of EPE. Cox regression analyses were performed to identify predictors of recurrence.142 patients (77 men; 64.7 ± 9.3 years) who underwent preoperative CT (n = 134) or MRI (n = 115) were included. Duct dilatation was a common imaging finding of s-PDA (CT: 75.4%, MRI: 82.6%). Of the 142 patients, 21.8% (31/142) had no EPE, while 78.2% (111/142) had EPE. Tumor size on CT (14.3 ± 8.7 mm vs. 18.2 ± 6.5 mm, p =.01) and abutment or encasement of superior mesenteric vein (13.8% vs. 40.9%, p =.02) on CT were different according to absence or presence of EPE. Recurrence was more common in s-PDA with EPE (32.3% [10/31] vs. 53.2% [59/111], p =.04). Pathologic tumor size (HR 1.103, 95% CI 1.020-1.193, p =.01), tumor size on MRI (HR 1.044, 95% CI 1.001-1.090, p =.048), and extrapancreatic neural invasion on MRI (HR 3.341, 95% CI 1.564-7.140, p =.002) were significant predictors of recurrence.Even in s-PDA, tumors with EPE are larger and show higher recurrence rates. Imaging features are important for predicting presence of EPE.
rights: © 2025. The Author(s).
has PII: 10.1007/s00261-025-04831-0
doi: 10.1007/s00261-025-04831-0
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ryu RR
      type: Person
      first name: Rae Rim
      last name: Ryu
      member of: Chung-Ang University Hospital, Seoul, Korea, Republic of.
  slot:
    index: 2
    item: Kim JH
      type: Person
      first name: Jung Hoon
      last name: Kim
      member of: Seoul National University, Seoul, Korea, Republic of. jhkim2008@gmail.com.Seoul National University Hospital, Seoul, Korea, Republic of. jhkim2008@gmail.com.
  slot:
    index: 3
    item: Park J
      type: Person
      first name: Junghoan
      last name: Park
      member of: Seoul National University Hospital, Seoul, Korea, Republic of.
  slot:
    index: 4
    item: Hwang S
      type: Person
      first name: Sungjun
      last name: Hwang
      member of: Inje University Ilsan Paik Hospital, Goyang-si, Korea, Republic of.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:23
e ISSN: 2366-0058
has NLM journal title abbreviation: Abdom Radiol (NY)
publication name: Abdominal radiology (New York)
language: eng
has national library of medicine journal id: 101674571
derived from: NLM
has place of publication: United States
source: Abdom Radiol (NY). 2025-02-14;():.

Lactiplantibacillus plantarum ZJ316 Alleviates Helicobacter pylori-Induced Intestinal Inflammation by Sustaining Intestinal Homeostasis.
pmid: 39948232
abstract: Helicobacter pylori (H. pylori) infection poses significant risks for gastric cancer and intestinal inflammation, yet effective prevention strategies for intestinal inflammation remain elusive. Here, we aimed to investigate the protective effects and underlying mechanisms of Lactiplantibacillus plantarum ZJ316 (L. plantarum ZJ316) in a mouse model of H. pylori-induced intestinal inflammation. The reverse transcription‑quantitative polymerase chain reaction (RT-qPCR) analysis showed that treatment with L. plantarum ZJ316 significantly upregulated the mRNA levels of tight junction proteins, including Zonula occludens-1 (ZO-1), Occludin, and Claudin-1, while simultaneously decreasing the expression levels of pro-inflammatory cytokines interleukin-1β (IL-1β), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). Additionally, 16S rDNA sequencing analysis revealed that administration of L. plantarum ZJ316 reduced relative abundance of pathogenic bacteria, Staphylococcus and Desulfovibrio by 69% and 42%, respectively, while enhancing beneficial bacteria including Ligilactobacillus, Akkermansia, and Lactobacillus associated with short-chain fatty acids (SCFAs) synthesis by 88%, 85%, and 16%, respectively. Gas chromatography-mass spectrometry (GC-MS) analysis confirmed L. plantarum ZJ316 restored SCFA levels reduced by H. pylori infection. In vitro, L. plantarum ZJ316 inhibited the IκBα/NF-κB pathway, thereby reducing TNF-α and IL-8 production in HT-29 cells following H. pylori infection. These findings collectively suggest that L. plantarum ZJ316 ameliorates H. pylori-induced intestinal inflammation by enhancing gut barrier function, improving flora structure, increasing SCFA levels, and mitigating inflammation through NF-κB pathway inhibition, offering promise for therapeutic development.
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12602-025-10474-w
doi: 10.1007/s12602-025-10474-w
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Wu S
      type: Person
      first name: Shiying
      last name: Wu
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China. wushiying@zjgsu.edu.cn.
  slot:
    index: 2
    item: Wei F
      type: Person
      first name: Fangtong
      last name: Wei
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 3
    item: Chen Y
      type: Person
      first name: Yongqiang
      last name: Chen
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 4
    item: Chen Z
      type: Person
      first name: Ziqi
      last name: Chen
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 5
    item: Luo Y
      type: Person
      first name: Yuenuo
      last name: Luo
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 6
    item: Fan J
      type: Person
      first name: Jiayi
      last name: Fan
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 7
    item: Xu Y
      type: Person
      first name: Yang
      last name: Xu
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 8
    item: Hu M
      type: Person
      first name: Mingyang
      last name: Hu
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 9
    item: Li P
      type: Person
      first name: Ping
      last name: Li
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China.
  slot:
    index: 10
    item: Gu Q
      type: Person
      first name: Qing
      last name: Gu
      member of: Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, Zhejiang, China. guqing2002@hotmail.com.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:24
e ISSN: 1867-1314
has issn l: 1867-1306
has NLM journal title abbreviation: Probiotics Antimicrob Proteins
publication name: Probiotics and antimicrobial proteins
language: eng
has national library of medicine journal id: 101484100
derived from: NLM
has place of publication: United States
source: Probiotics Antimicrob Proteins. 2025-02-13;():.

AI-based tumor-stroma ratio quantification algorithm: comprehensive evaluation of prognostic role in primary colorectal cancer.
pmid: 39948241
abstract: Tumor-stroma ratio (TSR quantification in primary colorectal cancer is an important prognostic parameter, with stroma-rich tumors considered to have an unfavorable prognosis. Earlier studies involved relevant region selection and TSR quantification by human analysts, who are prone to interobserver variability. The aim of the current study was to develop a fully automated, quantitative algorithm for TSR analysis based on precise segmentation of H&E-stained histological tissue sections. The TSR quantification algorithm was developed based on the segmentation backbone, allowing accurate pixel-wise mapping of all relevant tissue classes (n = 12), including tumor cells, tumoral stroma, necrosis, and mucin. Three well-characterized cohorts of patients with stage I-IV primary operable colorectal cancer and available digital H&E histological slides were included (n = 548, n = 147, and n = 622, respectively). Three sizes of area for TSR analysis were tested (1.0, 1.5, and 2.0 mm). The maximal TSR value per case was used for prognostic analysis involving different clinical endpoints. Regional heterogeneity of TSR was high in most tumors, with the algorithm effectively finding the most relevant region for analysis. Maximal case-level TSR values depended on the size of the area for analysis, which also significantly influences the prognostic performance of the TSR and must be a matter of standardization. In Cox analysis, an analytical size of 1 mm allowed the best performance, with an independent prognostic role retained in the context of other pathological variables for progression-free survival, cancer-specific survival, and overall survival endpoints. A powerful, fully automated, fully quantitative, objective tool for TSR assessment in primary colorectal cancer was developed and validated to have independent prognostic value. Standardization of TSR quantification is important given that analytical parameters can substantially influence the prognostic performance.
rights: © 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00428-025-04048-y
doi: 10.1007/s00428-025-04048-y
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Carvalho R
      type: Person
      first name: Rita
      last name: Carvalho
      member of: Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.Medical Faculty, University of Cologne, Cologne, Germany.
  slot:
    index: 2
    item: Zander T
      type: Person
      first name: Thomas
      last name: Zander
      member of: Clinic of Internal Medicine, Oncology, University Hospital Cologne, Cologne, Germany.
  slot:
    index: 3
    item: Barroso VM
      type: Person
      first name: Vincenzo Mitchell
      last name: Barroso
      member of: Medical Faculty, University of Cologne, Cologne, Germany.
  slot:
    index: 4
    item: Bekisoglu A
      type: Person
      first name: Ahmet
      last name: Bekisoglu
      member of: Medical Faculty, University of Cologne, Cologne, Germany.
  slot:
    index: 5
    item: Zerbe N
      type: Person
      first name: Norman
      last name: Zerbe
      member of: Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  slot:
    index: 6
    item: Klein S
      type: Person
      first name: Sebastian
      last name: Klein
      member of: Insitute of Pathology, University Hospital Cologne, Cologne, Germany.
  slot:
    index: 7
    item: Büttner R
      type: Person
      first name: Reinhard
      last name: Büttner
      member of: Insitute of Pathology, University Hospital Cologne, Cologne, Germany.
  slot:
    index: 8
    item: Quaas A
      type: Person
      first name: Alexander
      last name: Quaas
      member of: Insitute of Pathology, University Hospital Cologne, Cologne, Germany.
  slot:
    index: 9
    item: Tolkach Y
      type: Person
      first name: Yuri
      last name: Tolkach
      member of: Insitute of Pathology, University Hospital Cologne, Cologne, Germany. yuri.tolkach@gmail.com.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:24
e ISSN: 1432-2307
has issn l: 0945-6317
has NLM journal title abbreviation: Virchows Arch
publication name: Virchows Archiv : an international journal of pathology
language: eng
has national library of medicine journal id: 9423843
derived from: NLM
has place of publication: Germany
source: Virchows Arch. 2025-02-13;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39948242
pmid: 39948242
abstract: Mesonephric-like adenocarcinoma is a rare subtype of endometrial cancer, characterized by its histological and molecular overlap with mesonephric carcinoma of the uterine cervix. This study presents a unique case of mesonephric-like adenocarcinoma in the endometrium, accompanied by adjacent mesonephric-like hyperplasia and atypical mesonephric-like hyperplasia. Histologically, the transition from mesonephric metaplasia to adenocarcinoma was evident, and molecular analysis revealed shared mutations, including KRAS (p.G12D) in both atypical hyperplasia and adenocarcinoma, and a novel BCOR mutation (p.A1314Nfs*49) in the adenocarcinoma. These findings suggest a Müllerian origin of mesonephric-like adenocarcinoma via mesonephric transdifferentiation, challenging the traditional understanding of mesonephric histogenesis. The identification of these mutations underscores the potential for targeted therapies, particularly in cases with BCOR and KRAS mutations. This study is the first to document preneoplastic lesions in mesonephric-like adenocarcinoma, offering new insights into its pathogenesis and therapeutic implications.
rights: © 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00428-024-03972-9
doi: 10.1007/s00428-024-03972-9
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Santoro A
      type: Person
      first name: Angela
      last name: Santoro
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 2
    item: Angelico G
      type: Person
      first name: Giuseppe
      last name: Angelico
      member of: Department of Medicine and Surgery, Kore University of Enna, 94100, Enna, Italy.
  slot:
    index: 3
    item: Narducci N
      type: Person
      first name: Nadine
      last name: Narducci
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 4
    item: Travaglino A
      type: Person
      first name: Antonio
      last name: Travaglino
      member of: Pathology Unit, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
  slot:
    index: 5
    item: Piermattei A
      type: Person
      first name: Alessia
      last name: Piermattei
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 6
    item: Inzani F
      type: Person
      first name: Frediano
      last name: Inzani
      member of: Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, 27100, Pavia, Italy.
  slot:
    index: 7
    item: Arciuolo D
      type: Person
      first name: Damiano
      last name: Arciuolo
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 8
    item: Addante F
      type: Person
      first name: Francesca
      last name: Addante
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 9
    item: Urtueta BP
      type: Person
      first name: Belen Padial
      last name: Urtueta
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 10
    item: Tinnirello G
      type: Person
      first name: Giordana
      last name: Tinnirello
      member of: Department of Medical and Surgical Sciences and Advanced Technologies G.F. Ingrassia , Anatomic Pathology, University of Catania, Catania, Italy.
  slot:
    index: 11
    item: Scaglione G
      type: Person
      first name: Giulia
      last name: Scaglione
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 12
    item: D'Alessandris N
      type: Person
      first name: Nicoletta
      last name: D'Alessandris
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 13
    item: Valente M
      type: Person
      first name: Michele
      last name: Valente
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy.
  slot:
    index: 14
    item: Minucci A
      type: Person
      first name: Angelo
      last name: Minucci
      member of: Departmental Unit of Molecular and Genomic Diagnostics, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
  slot:
    index: 15
    item: Zannoni GF
      type: Person
      first name: Gian Franco
      last name: Zannoni
      member of: Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy. gianfranco.zannoni@unicatt.it.Pathology Institute, Catholic University of Sacred Heart, 00168, Rome, Italy. gianfranco.zannoni@unicatt.it.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:24
e ISSN: 1432-2307
has issn l: 0945-6317
has NLM journal title abbreviation: Virchows Arch
publication name: Virchows Archiv : an international journal of pathology
language: eng
has national library of medicine journal id: 9423843
derived from: NLM
has place of publication: Germany
source: Virchows Arch. 2025-02-14;():.
title: Mesonephric-like adenocarcinoma of the endometrium: detailed molecular characterization of the first case showing a morphological continuum from mesonephric-like metaplasia and atypical mesonephric-like hyperplasia to adenocarcinoma.

Scientists use AI to design life-like enzymes from scratch.
pmid: 39948255
has PII: 10.1038/d41586-025-00488-3
doi: 10.1038/d41586-025-00488-3
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Naddaf M
      type: Person
      first name: Miryam
      last name: Naddaf
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:25
e ISSN: 1476-4687
has issn l: 0028-0836
has NLM journal title abbreviation: Nature
publication name: Nature
language: eng
has national library of medicine journal id: 0410462
derived from: NLM
has place of publication: England
source: Nature. 2025-02-13;():.

Are the Trump team's actions affecting your research? How to contact Nature.
pmid: 39948250
has PII: 10.1038/d41586-025-00479-4
doi: 10.1038/d41586-025-00479-4
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:25
e ISSN: 1476-4687
has issn l: 0028-0836
has NLM journal title abbreviation: Nature
publication name: Nature
language: eng
has national library of medicine journal id: 0410462
derived from: NLM
has place of publication: England
source: Nature. 2025-02-13;():.

In-silico Study of an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase (SAHH) of Naegleria fowleri using Molecular Docking, Density Functional Theory (DFT), and Molecular Dynamics (MD) Simulation.
pmid: 39948258
abstract: Naegleria fowleri causes primary amoebic meningoencephalitis (PAM), a lethal disease with a mortality rate of 97%. Current treatment options are limited and often ineffective, highlighting the urgent need for novel therapeutic agents. This study aimed to identify potential inhibitors of the S-adenosyl-L-homocysteine hydrolase (SAHH) enzyme from N. fowleri using an in-silico approach including Molecular Docking, Density Functional Theory (DFT), Molecular Dynamics (MD) simulation, and Molecular Mechanics Generalized Born Surface Area (MMGBSA) analysis. This study included compounds capable of crossing the blood-brain barrier after screening the Asinex Library of 261120 compounds. After molecular docking, ligands had binding energies ranging from - 5.3 to - 11.4 kcal/mol. Only one ligand 2-[(3-Chlorobenzoyl)amino]-N-(2,3-dihydro-1H-inden-5-yl)-4-methyl-1,3-thiazole-5-carboxamide had a better binding energy of - 11.4 kcal/mol as compared to the reference compound adenosine (- 10.1 kcal/mol). DFT calculations revealed HOMO-LUMO energy gaps of 0.14301 eV (α-spin) and 0.07565 eV (β-spin). MD simulations conducted throughout 100 ns confirmed the stable binding and interaction of the ligand with key active site residues, including Asp130, His232, Phe150, Leu200, and Lys68. Stable root-mean-square deviation (RMSD) and continuous interactions between the ligand and critical active site residues were observed. MMGBSA analysis confirmed the ligand's strong binding affinity, indicated by a negative binding energy with substantial lipophilic and Coulombic contributions. The selected ligand demonstrated significant binding affinity, stability, and inhibitory potential against NfSAHH, making it a promising candidate for further development as a therapeutic agent against PAM. The findings reveal novel binding interactions and structural insights into the binding mechanism of NfSAHH inhibitors. By employing a strategic in silico approach, this study provides a robust foundation for id[cell cut: 2143 characters, first 2000 kept]
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12033-025-01389-6
doi: 10.1007/s12033-025-01389-6
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Shah SSTH
      type: Person
      first name: Syed Sib Tul Hassan
      last name: Shah
      member of: Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, 310018, China.Department of Life Science, School of Science, University of Management and Technology (UMT), Lahore, Pakistan.
  slot:
    index: 2
    item: Naeem I
      type: Person
      first name: Iqra
      last name: Naeem
      member of: Department of Life Science, School of Science, University of Management and Technology (UMT), Lahore, Pakistan.Dr. Ikram-ul-Haq Institute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan.
  slot:
    index: 3
    item: Akram F
      type: Person
      first name: Fatima
      last name: Akram
      member of: Dr. Ikram-ul-Haq Institute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan. fatimaakram@gcu.edu.pk.Department of Biology, Saint Louis University, St. Louis, MO, 63103, USA. fatimaakram@gcu.edu.pk.
  slot:
    index: 4
    item: Akhtar MT
      type: Person
      first name: Muhammad Tayyab
      last name: Akhtar
      member of: Dr. Ikram-ul-Haq Institute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan.
  slot:
    index: 5
    item: Noor F
      type: Person
      first name: Fatima
      last name: Noor
      member of: Department of Zoology, Government College University, Faisalabad, Punjab, Pakistan.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:25
e ISSN: 1559-0305
has issn l: 1073-6085
has NLM journal title abbreviation: Mol Biotechnol
publication name: Molecular biotechnology
language: eng
has national library of medicine journal id: 9423533
derived from: NLM
has place of publication: Switzerland
source: Mol Biotechnol. 2025-02-13;():.

Comparative analysis of transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) in atrial fibrillation ablation: insights from the real-world experience registry.
pmid: 39948279
has PII: 10.1007/s10840-025-02013-y
doi: 10.1007/s10840-025-02013-y
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Minga I
      type: Person
      first name: Iva
      last name: Minga
      member of: The University of Chicago Medical Center, Chicago, IL, USA.
  slot:
    index: 2
    item: Lee K
      type: Person
      first name: Kevin
      last name: Lee
      member of: Northshore University Health System, Evanston, IL, USA.
  slot:
    index: 3
    item: Golemi L
      type: Person
      first name: Lolita
      last name: Golemi
      member of: Saint Louis University, St. Louis, MO, USA. lolitagolemi1@gmail.com.
  slot:
    index: 4
    item: Varley A
      type: Person
      first name: Allyson
      last name: Varley
      member of: Heart Rhythm Clinical Research Solutions, Birmingham, AL, USA.
  slot:
    index: 5
    item: Thorne C
      type: Person
      first name: Christopher
      last name: Thorne
      member of: Heart Rhythm Clinical Research Solutions, Birmingham, AL, USA.
  slot:
    index: 6
    item: Osorio J
      type: Person
      first name: Jose
      last name: Osorio
      member of: HCA Miami, Miami, FL, USA.
  slot:
    index: 7
    item: Hebsur S
      type: Person
      first name: Shrinivas
      last name: Hebsur
      member of: Trinity Health Michigan Health, Ypsilanti, MI, USA.
  slot:
    index: 8
    item: Rajendra A
      type: Person
      first name: Anil
      last name: Rajendra
      member of: Alabama Cardiovascular Group, Columbiana, AL, USA.
  slot:
    index: 9
    item: Morales G
      type: Person
      first name: Gustavo
      last name: Morales
      member of: Alabama Cardiovascular Group, Columbiana, AL, USA.
  slot:
    index: 10
    item: Oza S
      type: Person
      first name: Saumil
      last name: Oza
      member of: Ascension Medical Group St. Vincent's Riverview, Jacksonville, FL, USA.
  slot:
    index: 11
    item: Magnano A
      type: Person
      first name: Anthony
      last name: Magnano
      member of: Ascension Medical Group St. Vincent's Riverview, Jacksonville, FL, USA.
  slot:
    index: 12
    item: Di Biase L
      type: Person
      first name: Luigi
      last name: Di Biase
      member of: Montefiore Medical Center, Bronx, NY, USA.
  slot:
    index: 13
    item: Singleton M
      type: Person
      first name: Matthew
      last name: Singleton
      member of: WellSpan Health, York, PA, USA.
  slot:
    index: 14
    item: Zei PC
      type: Person
      first name: Paul C
      last name: Zei
      member of: Brigham Women's Hospital, Cambridge, MA, USA.
  slot:
    index: 15
    item: Dsouza B
      type: Person
      first name: Benjamin
      last name: Dsouza
      member of: Penn Presbyterian Medical Center, Philadelphia, PA, USA.
  slot:
    index: 16
    item: Silverstein J
      type: Person
      first name: Joshua
      last name: Silverstein
      member of: Allegheny Health Network, Pittsburgh, PA, USA.
  slot:
    index: 17
    item: Metzl M
      type: Person
      first name: Mark
      last name: Metzl
      member of: The University of Chicago Medical Center, Chicago, IL, USA.Northshore University Health System, Evanston, IL, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:26
e ISSN: 1572-8595
has issn l: 1383-875X
has NLM journal title abbreviation: J Interv Card Electrophysiol
publication name: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
language: eng
has national library of medicine journal id: 9708966
derived from: NLM
has place of publication: Netherlands
source: J Interv Card Electrophysiol. 2025-02-13;():.

TUFT1 Modulates Cell Proliferation, Migration, Invasion, Stemness and EGFR Signaling in Cervical Cancer through Interacting with and Targeting ATF1.
pmid: 39948288
abstract: Cervical cancer remains a frequently-occurring gynecologic health problem posing a great threat to women. Tuftelin1 (TUFT1), an acidic protein possessing secretory capacity, has been reported to drive cisplatin resistance in cervical cancer cells. Accordingly, the current study is intended to figure out the specific impacts of TUFT1 on the aggressive behaviors of cervical cancer cells and make an in-depth study into the related regulatory mechanism. Firstly, analysis of TUFT1 expression in cervical cancer cells was performed by RT-qPCR and Western blotting. Cervical cancer cell proliferation was estimated via CCK-8 and colony formation assays. Wound healing, transwell as well as sphere formation assays were used to appraise cell migration, invasion, and stemness, respectively. Western blotting examined the expressions of metastasis- and stemness-associated factors and RT-qPCR also tested the expressions of stemness-associated factors. Co-IP assay was used to verify the binding between TUFT1 and activating transcription factor 1 (ATF1). Subsequent ATF1 expression was examined by RT-qPCR and Western blotting after TUFT1 was silenced. After co-transfected with TUFT1 interference and ATF1 overexpression plasmids, aforementioned functional experiments were conducted again. Western blotting also analyzed the expressions of epidermal growth factor receptor (EGFR) signaling-associated proteins. The experimental data determined that TUFT1 expression was fortified in cervical cancer cells and TUFT1 absence diminished cervical cancer cell proliferation, migration, invasion, and stemness. Besides, TUFT1 bond to ATF1 and positively modulated ATF1 expression. Moreover, ATF1 elevation countervailed the impacts of TUFT1 insufficiency on the proliferation, migration, invasion, stemness as well as EGFR signaling in cervical cancer cells. Anyway, TUFT1 might interact with ATF1 to elicit pro-proliferation, pro-metastasis, and pro-stemness properties and inactivate EGFR signaling in cer[cell cut: 2096 characters, first 2000 kept]
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12013-025-01673-x
doi: 10.1007/s12013-025-01673-x
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Han C
      type: Person
      first name: Chunhua
      last name: Han
      member of: Department of Gynaecology, Qujing Maternal and Child Health Care Hospital, Qujing, Yunnan Province, China.
  slot:
    index: 2
    item: Gao H
      type: Person
      first name: Huifen
      last name: Gao
      member of: Department of Gynaecology, Qujing Maternal and Child Health Care Hospital, Qujing, Yunnan Province, China.
  slot:
    index: 3
    item: Li F
      type: Person
      first name: Fengqiong
      last name: Li
      member of: Department of Gynaecology, Qujing Maternal and Child Health Care Hospital, Qujing, Yunnan Province, China.
  slot:
    index: 4
    item: Lin L
      type: Person
      first name: Lin
      last name: Lin
      member of: Department of Gynaecology, Qujing Maternal and Child Health Care Hospital, Qujing, Yunnan Province, China.
  slot:
    index: 5
    item: Qian M
      type: Person
      first name: Muying
      last name: Qian
      member of: Department of Gynaecology, Qujing Maternal and Child Health Care Hospital, Qujing, Yunnan Province, China.
  slot:
    index: 6
    item: Feng L
      type: Person
      first name: Lin
      last name: Feng
      member of: Department of Gynaecology, Qujing Maternal and Child Health Care Hospital, Qujing, Yunnan Province, China. FengLin6023@163.com.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:27
e ISSN: 1559-0283
has issn l: 1085-9195
has NLM journal title abbreviation: Cell Biochem Biophys
publication name: Cell biochemistry and biophysics
language: eng
has national library of medicine journal id: 9701934
derived from: NLM
has place of publication: United States
source: Cell Biochem Biophys. 2025-02-13;():.

Juglone Encapsulation in PLGA Nanoparticles Improves Solubility and Enhances Apoptosis in HeLa Cells.
pmid: 39948289
abstract: The anticancer potential of juglone, a naphthoquinone derived from walnut trees, has been extensively studied; however, its hydrophobicity and toxicity obstruct its therapeutic applications. This study aimed to overcome these challenges by encapsulating juglone into poly (lactic-co-glycolic acid) (PLGA) nanoparticles and evaluating their antiproliferative and apoptotic effects on HeLa cells. Juglone nanoparticles (JNP) were obtained by single emulsion solvent evaporation method. Its key physicochemical properties, such as particle size, zeta potential, drug loading, release yield, and encapsulation efficiency values were calculated as 207.45 ± 1.67 nm, -24.12 ± 2.21 mV, 47.80, 66.90 and 90.12%, respectively. JNP's antiproliferative effects were compared to those of free juglone on HeLa cells. The calculated IC50 values for free juglone and JNPs were 17.07 µM and 20.64 µM, respectively. Both formulations exhibited comparable dose-dependent antiproliferative effects across the tested concentrations. However, the nanoparticle-based delivery system demonstrated enhanced apoptotic activity, as evidenced by increased caspase-3 activation and greater suppression of BCL-2 levels relative to free juglone. These findings were further corroborated by TUNEL and immunocytochemical analyses, which confirmed the superior apoptotic induction by the nanosystem. Collectively, the results highlight the potential advantages of PLGA-based nanoparticle systems for the delivery of juglone, thereby improving its water solubility-a key limiting factor for its use-while minimizing its toxicity. These findings offer a promising approach for its application as an effective anticancer agent via nanoparticle-based delivery.
rights: © 2025. The Author(s).
has PII: 10.1007/s12013-025-01691-9
doi: 10.1007/s12013-025-01691-9
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Yilmaz DE
      type: Person
      first name: Duygu Elif
      last name: Yilmaz
      member of: Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  slot:
    index: 2
    item: Gumus B
      type: Person
      first name: Busra
      last name: Gumus
      member of: Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Yildiz Technical University, Istanbul, Turkey.
  slot:
    index: 3
    item: Demirci H
      type: Person
      first name: Hasan
      last name: Demirci
      member of: Institute of Functional Anatomy, Charité - Universitätsmedizin Berlin, Berlin, Germany. hasan.demirci@charite.de.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:27
e ISSN: 1559-0283
has issn l: 1085-9195
has NLM journal title abbreviation: Cell Biochem Biophys
publication name: Cell biochemistry and biophysics
language: eng
has national library of medicine journal id: 9701934
derived from: NLM
has place of publication: United States
source: Cell Biochem Biophys. 2025-02-14;():.

Brief Report: Eating Habits and Social Setting: Comparing Children with Autism and Typically Developing Children.
pmid: 39948292
abstract: Eating problems are commonly reported as co-occurring conditions in individuals with autism spectrum disorder (ASD) and are also prevalent among typically developing (TD) children. While it has been shown that eating problems in TD children are influenced by social settings, this factor has not been extensively studied in children with ASD.This study compared the perspectives of parents and preschool teachers on the eating habits of both ASD and TD children. The study included children aged 29-81 months, 34 TD children, and 31 children diagnosed with ASD who attended special education preschool classes specifically designed for them.The findings revealed that parental and preschool teacher reports were generally consistent, but parents tended to report more severe eating problems for both groups of children. Thus, pointing to the impact of social settings on eating in ASD. Additionally, the reports indicated that eating problems were more severe in children with ASD compared to TD children.These findings underscore the significant influence of social settings on children's eating behavior. It is essential for education and treatment teams to recognize that eating habits may vary between home and preschool environments. They should be attentive to parents' concerns regarding their children's eating habits at home and provide appropriate support and guidance.
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10803-025-06746-7
doi: 10.1007/s10803-025-06746-7
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Saban-Bezalel R
      type: Person
      first name: Ronit
      last name: Saban-Bezalel
      member of: Department of Communication Disorders, Bruckner Center for Autism Research, Ariel University, 40700, Ariel, Israel. Ronitsa@ariel.ac.il.
  slot:
    index: 2
    item: Stolar O
      type: Person
      first name: Orit
      last name: Stolar
      member of: Child Development Centers, Sharon District-Maccabi Healthcare Services, Tel-Aviv, Israel.
  slot:
    index: 3
    item: Ben-Itzchak E
      type: Person
      first name: Esther
      last name: Ben-Itzchak
      member of: Department of Communication Disorders, Bruckner Center for Autism Research, Ariel University, 40700, Ariel, Israel.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:27
e ISSN: 1573-3432
has issn l: 0162-3257
has NLM journal title abbreviation: J Autism Dev Disord
publication name: Journal of autism and developmental disorders
language: eng
has national library of medicine journal id: 7904301
derived from: NLM
has place of publication: United States
source: J Autism Dev Disord. 2025-02-13;():.

The Relationship Between Interoception, Alexithymia, Autistic Traits and Eating Pathology in Autistic Adults.
pmid: 39948294
abstract: This study investigated the mechanisms underlying disordered eating of autistic adults, by investigating associations between eating disorder (ED) symptoms and autistic traits; autism-specific atypical eating; alexithymia; interoception; and body image in autistic and non-autistic participants. Autistic adults (n = 196) and non-autistic adults (n = 206) completed online self-report measures assessing ED pathology, atypical eating, body image dissatisfaction, interoception, alexithymia, and autistic traits. Structural Equation Modelling tested a theoretical model of the relationships between these variables, and whether these relationships were moderated by autism diagnosis. Autistic adults self-reported higher ED pathology than non-autistic adults. The proposed model and the strength of the relationship between body image and ED pathology did not differ between the autistic and non-autistic groups. Atypical eating (not related to over-evaluation of weight/shape), however, was only associated with ED pathology in the autistic group. Both traditional and additional factors, including eating disturbances not driven by weight/shape concern, appear to contribute to ED pathology in autism.
rights: © 2024. The Author(s).
has PII: 10.1007/s10803-024-06708-5
doi: 10.1007/s10803-024-06708-5
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Westwood H
      type: Person
      first name: Heather
      last name: Westwood
      member of: NHS Lothian, Edinburgh, UK.Royal Holloway, University of London, Egham Hill, Egham, TW20, UK.
  slot:
    index: 2
    item: Mandy W
      type: Person
      first name: Will
      last name: Mandy
      member of: University College, London, UK.
  slot:
    index: 3
    item: Brewer R
      type: Person
      first name: Rebecca
      last name: Brewer
      member of: Royal Holloway, University of London, Egham Hill, Egham, TW20, UK. Rebecca.Brewer@rhul.ac.uk.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:27
e ISSN: 1573-3432
has issn l: 0162-3257
has NLM journal title abbreviation: J Autism Dev Disord
publication name: Journal of autism and developmental disorders
language: eng
has national library of medicine journal id: 7904301
derived from: NLM
has place of publication: United States
source: J Autism Dev Disord. 2025-02-14;():.

A Pilot Randomized Trial of a Brief Mental Health Crisis Prevention Program for Autistic Youth.
pmid: 39948293
abstract: Autistic youth are at significant risk of experiencing a mental health crisis. Unfortunately, most clinical approaches to crisis management, such as referral to the emergency department, can be traumatic. At present, no crisis prevention programs have been developed for or rigorously tested among autistic youth. The goals of this study were to develop a parent-mediated mental health crisis prevention program, delivered virtually by a licensed clinician over three 1-h sessions, and test its efficacy via a randomized controlled trial. The trial included 49 autistic youth, ages 3 to 12 years, and their parents, who were recruited from an outpatient autism center. All children had behavioral concerns but were not at acute risk of crisis. Parents in the crisis prevention program (n = 25) reported that the strategies were safe and feasible; they were also very satisfied with the program. Compared to active controls (n = 24), who received the Autism Speaks Challenging Behavior Toolkit, the crisis prevention program was found to have greater improvements in caregiver-reported knowledge, confidence, and preparedness regarding management of crisis behaviors (p < .05). However, effects on caregiver-reported child irritability and behavioral acuity did not differ (p > .05). The brief crisis prevention program is safe, feasible, and acceptable to parents. While it improves mental health crisis preparedness, further research on its efficacy in reducing crisis risk is needed.
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s10803-025-06743-w
doi: 10.1007/s10803-025-06743-w
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Kalb LG
      type: Person
      first name: Luther G
      last name: Kalb
      member of: Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD, 21211, USA. kalb@kennedykrieger.org.Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. kalb@kennedykrieger.org.
  slot:
    index: 2
    item: Perrin J
      type: Person
      first name: Jeremy
      last name: Perrin
      member of: Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD, 21211, USA.
  slot:
    index: 3
    item: Sollins E
      type: Person
      first name: Elie
      last name: Sollins
      member of: Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD, 21211, USA.
  slot:
    index: 4
    item: Horton J
      type: Person
      first name: Jennifer
      last name: Horton
      member of: Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD, 21211, USA.
  slot:
    index: 5
    item: Cross EA
      type: Person
      first name: Elizabeth A
      last name: Cross
      member of: Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD, 21211, USA.Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  slot:
    index: 6
    item: Vasa RA
      type: Person
      first name: Roma A
      last name: Vasa
      member of: Center for Autism Services, Science and Innovation, Kennedy Krieger Institute, 3901 Greenspring Avenue, Baltimore, MD, 21211, USA.Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:27
e ISSN: 1573-3432
has issn l: 0162-3257
has NLM journal title abbreviation: J Autism Dev Disord
publication name: Journal of autism and developmental disorders
language: eng
has national library of medicine journal id: 7904301
derived from: NLM
has place of publication: United States
source: J Autism Dev Disord. 2025-02-13;():.

Teacher-Student Interactions of Autistic Adolescents: Relationships between Teacher Autonomy Support, Structure, Involvement and Student Engagement.
pmid: 39948295
abstract: The extent to which autistic students are provided with autonomy-support, structure and involvement during the teacher-student interaction has been under-researched. Few studies have focused on autistic secondary school students and even fewer have used observations to analyze their interactions. In this research, we aimed to understand the interaction dynamics between autistic students and their teachers in the Netherlands and Mexico; two countries committed to inclusive education. Six teacher-student dyads from five mainstream secondary schools in the Netherlands and seven teacher-student dyads from one school in Mexico participated. We used a fine-grained observational method to describe the classroom interactions, systematically coded from the lens of Self-Determination Theory. To study the interaction as a whole and co-occurring teacher and student behaviors (rather than breaking it down into separate parts), we used State Space Grids. Teacher-student interactions varied widely. In general, Dutch and Mexican teachers provided much structure in the classroom, which (in many cases) coincided with the active engagement of autistic students. At the same time, autistic students in both countries received little autonomy-support. However, when these students received autonomy-support, they responded with more engagement. In contrast, both engaged and disengaged student behaviors occurred when the teacher showed involvement. The desired patterns of interaction were not observed in all teacher-student pairs. Our findings indicate that teachers in both countries are missing opportunities to be autonomy-supportive. This contextual factor was minimally observed in the teacher-student interactions, particularly when compared to the levels of structure and involvement provided during lessons.
rights: © 2025. The Author(s).
has PII: 10.1007/s10803-025-06723-0
doi: 10.1007/s10803-025-06723-0
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Esqueda Villegas F
      type: Person
      first name: Fernanda
      last name: Esqueda Villegas
      member of: Department of Inclusive and Special Needs Education, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, Groningen, 9712 TS, The Netherlands. m.f.esqueda.villegas@rug.nl.
  slot:
    index: 2
    item: van der Steen S
      type: Person
      first name: Steffie
      last name: van der Steen
      member of: Department of Inclusive and Special Needs Education, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, Groningen, 9712 TS, The Netherlands.
  slot:
    index: 3
    item: van Dijk M
      type: Person
      first name: Marijn
      last name: van Dijk
      member of: Department of Inclusive and Special Needs Education, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, Groningen, 9712 TS, The Netherlands.
  slot:
    index: 4
    item: Esqueda Villegas DA
      type: Person
      first name: David Alejandro
      last name: Esqueda Villegas
      member of: Department of Integral Postgraduate Studies in Social Sciences, Faculty of Interdisciplinary Studies in Social Sciences, University of Sonora, Blvd. Luis Encinas J, Av. Rosales and Centro, Hermosillo, Sonora, 83000, Mexico.
  slot:
    index: 5
    item: Minnaert A
      type: Person
      first name: Alexander
      last name: Minnaert
      member of: Department of Inclusive and Special Needs Education, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, Groningen, 9712 TS, The Netherlands.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:27
e ISSN: 1573-3432
has issn l: 0162-3257
has NLM journal title abbreviation: J Autism Dev Disord
publication name: Journal of autism and developmental disorders
language: eng
has national library of medicine journal id: 7904301
derived from: NLM
has place of publication: United States
source: J Autism Dev Disord. 2025-02-14;():.

Endoscopic radial incision combined with local injection of triamcinolone acetonide for refractory esophageal stenosis after endoscopy submucosal dissection.
pmid: 39948302
abstract: Refractory esophageal stenosis (RES) after endoscopic submucosal dissection (ESD) is challenging in clinical practice. This study aimed to evaluate endoscopic radial incision (ERI) combined with the local injection of triamcinolone acetonide for RES and to assess its safety and efficacy. A total of nine patients (five males; age range: 50-76 years) who underwent ERI + triamcinolone acetonide for RES after ESD between August 2019 and November 2022 were analyzed. The primary endpoint was the duration of treatment. The length of the stenosed portion, procedure time, sessions of endoscopic therapy, effectiveness rate, success rate, dysphagia grade, complications, and quality of scores were also analyzed. The effectiveness and success rates were 100% and 88.9%, respectively. The mean number of sessions of ERI + triamcinolone acetonide was 2.2 (1.0-4.0). The mean procedure time was 25.9 ± 3.8 min. No severe complications, including bleeding or perforation, were observed during the perioperative period. Dysphagia symptoms were relieved in all patients after endoscopic treatment. Patients had significantly better functional scales for social functioning and global health status and lower rates of fatigue, gastrointestinal symptoms, and financial difficulties after treatment. ERI + triamcinolone acetonide can be considered a safe and effective treatment for RES after ESD. Larger prospective clinical trials are needed to confirm its utility.
rights: © 2025. Italian Society of Surgery (SIC).
has PII: 10.1007/s13304-025-02069-5
doi: 10.1007/s13304-025-02069-5
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Ng HI
      type: Person
      first name: Hoi-Ioi
      last name: Ng
      member of: Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
  slot:
    index: 2
    item: Liu Y
      type: Person
      first name: Yi
      last name: Liu
      member of: Department of Endoscopic Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  slot:
    index: 3
    item: Liu Y
      type: Person
      first name: Yong
      last name: Liu
      member of: Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
  slot:
    index: 4
    item: Dou LZ
      type: Person
      first name: Li-Zhou
      last name: Dou
      member of: Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
  slot:
    index: 5
    item: He S
      type: Person
      first name: Shun
      last name: He
      member of: Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
  slot:
    index: 6
    item: Wang GQ
      type: Person
      first name: Gui-Qi
      last name: Wang
      member of: Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. wangguiq@126.com.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:27
e ISSN: 2038-3312
has issn l: 2038-131X
has NLM journal title abbreviation: Updates Surg
publication name: Updates in surgery
language: eng
has national library of medicine journal id: 101539818
derived from: NLM
has place of publication: Italy
source: Updates Surg. 2025-02-13;():.

Safety of Using Tutoplast-Processed Fascia Lata in Rhinoplasty: A Systematic Review and Meta-Analysis.
pmid: 39948321
abstract: To evaluate the safety profile of using tutoplast-processed fascia lata (TPFL) as a graft material in patients undergoing both primary and revision rhinoplasty.PubMed, CENTRAL, Scopus, Web of Science, and EMBASE were searched. Eligible studies were evaluated for bias using the National Institutes of Health (NIH) assessment tool for cohort studies. Our safety outcomes included the incidence of graft resorption, infection, graft displacement, dorsal irregularity, overcorrected dorsal augmentation, and revision rates. Data were pooled as event rate (%) with a 95% confidence interval (CI) using STATA software.Nine studies, comprising 827 patients, were included. Eight studies were evaluated with a low risk of bias, and one study had a moderate risk of bias. The pooled proportion analysis demonstrated a low graft resorption rate (event rate = 2.64%, 95% CI [0.69%, 5.62%]), infection rate (event rate = 0.30%, 95% CI [0.02%, 0.83%]), dorsal irregularity rate (event rate = 0.96%, 95% CI [0.09%, 2.51%]), graft displacement rate (event rate = 0.45%, 95% CI [0.07%, 1.12%]), overcorrected dorsal augmentation rate (event rate = 1.29%, 95% CI [0.39%, 2.65%]), and revision rate (event rate = 3.99%, 95% CI [1.82%, 6.90%]).This meta-analysis of 827 patients demonstrated that TPFL has a favorable safety profile in both primary and revision rhinoplasty, with low complication and revision rates. TPFL, whether used alone or in combination with cartilage, is a viable graft option for dorsal augmentation and enhancing nasal dorsum contour.This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
rights: © 2025. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.
has PII: 10.1007/s00266-025-04727-w
doi: 10.1007/s00266-025-04727-w
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Al-Sebeih KH
      type: Person
      first name: Khalid H
      last name: Al-Sebeih
      member of: Department of Otorhinolaryngology and Facial Plastic Surgery, Lothan Hospital, Salmiya, Kuwait.
  slot:
    index: 2
    item: Albazee E
      type: Person
      first name: Ebraheem
      last name: Albazee
      member of: Otorhinolaryngology-Head and Neck Surgery, Kuwait Institute for Medical Specializations (KIMS), Kuwait City, Kuwait. Ebraheemalbazee@gmail.com.
  slot:
    index: 3
    item: Alsakka MA
      type: Person
      first name: Mahmoud A
      last name: Alsakka
      member of: Department of Otorhinolaryngology and Facial Plastic Surgery, Lothan Hospital, Salmiya, Kuwait.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:28
e ISSN: 1432-5241
has issn l: 0364-216X
has NLM journal title abbreviation: Aesthetic Plast Surg
publication name: Aesthetic plastic surgery
language: eng
has national library of medicine journal id: 7701756
derived from: NLM
has place of publication: United States
source: Aesthetic Plast Surg. 2025-02-13;():.

Constricted Lower Pole Breast Correction with High-Cohesivity Silicone Gel Anatomical Implant: Results from a 13-Year Single-Surgeon Experience.
pmid: 39948322
abstract: Lower pole constricted breasts, part of the spectrum of tuberous breast deformities, significantly impact patients' self-esteem and body image. To address the complexity and variety of clinical presentation of this type of deformity, a wide assortment of different surgical approaches has been proposed. The authors sought to determine the effectiveness of high-cohesivity silicone gel texturized anatomical implants in correcting lower pole constricted breast, emphasizing implant choice and the role of implant features on patient outcomes.The study retrospectively analyzed data from 468 Caucasian female patients treated from March 2009 to July 2022 for type I and II tuberous breast deformities. Surgical correction involved the use of extensive radial and horizontal scoring to release lower pole strictures and high-cohesiveness microtextured anatomical implants placement in a subfascial pocket. Major and minor complications during the follow-up were recorded.Implant volume ranged from 260cc to 495cc with an average of 345cc. We report minimal major complications (Baker grade III-IV capsular contracture 4.2%, implant rotation 1.4%) within a mean follow-up time of 60 months. Further implant-related complications including bottoming out, double-bubble deformity, and wrinkling were not observed.The selected surgical approach for correcting lower pole constricted breasts using high-cohesivity silicone gel texturized anatomical implants proves to be effective, offering predictable and satisfying outcomes for patients. The surgical approach, combining anatomical implant characteristics with precise lower pole expansion techniques, yielded stable, esthetically pleasing results that positively impacted patients' quality of life.This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
rights: © 2025. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.
has PII: 10.1007/s00266-025-04714-1
doi: 10.1007/s00266-025-04714-1
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Buccheri EM
      type: Person
      first name: Ernesto Maria
      last name: Buccheri
      member of: Medicinaplasticaroma Center, Plastic Surgery, Via Clitunno 22, 00198, Rome, Italy.
  slot:
    index: 2
    item: Villanucci A
      type: Person
      first name: Amedeo
      last name: Villanucci
      member of: Department of Breast Surgery, IFO - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy. amedeo.villanucci@gmail.com.
  slot:
    index: 3
    item: Montemurro P
      type: Person
      first name: Paolo
      last name: Montemurro
      member of: Akademikliniken, Storängsvägen, 1011541, Stockholm, Sweden.
  slot:
    index: 4
    item: De Vita R
      type: Person
      first name: Roy
      last name: De Vita
      member of: Department of Plastic and Reconstructive Surgery, IFO - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.
  slot:
    index: 5
    item: Rocco N
      type: Person
      first name: Nicola
      last name: Rocco
      member of: Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:28
e ISSN: 1432-5241
has issn l: 0364-216X
has NLM journal title abbreviation: Aesthetic Plast Surg
publication name: Aesthetic plastic surgery
language: eng
has national library of medicine journal id: 7701756
derived from: NLM
has place of publication: United States
source: Aesthetic Plast Surg. 2025-02-13;():.

The Value of Psychodynamic Play Techniques on the Pediatric Consultation-Liaison Service.
pmid: 39948324
has PII: 10.1007/s40596-025-02113-x
doi: 10.1007/s40596-025-02113-x
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Appel G
      type: Person
      first name: Giselle
      last name: Appel
      member of: Sidney Kimmel Medical College, Philadelphia, PA, USA. gxa338@students.jefferson.edu.
  slot:
    index: 2
    item: Granovetter MA
      type: Person
      first name: Madeleine A
      last name: Granovetter
      member of: Mount Sinai Hospital, New York, NY, USA.
  slot:
    index: 3
    item: Quaal H
      type: Person
      first name: Harrison
      last name: Quaal
      member of: Mount Sinai Hospital, New York, NY, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:28
e ISSN: 1545-7230
has issn l: 1042-9670
has NLM journal title abbreviation: Acad Psychiatry
publication name: Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
language: eng
has national library of medicine journal id: 8917200
derived from: NLM
has place of publication: United States
source: Acad Psychiatry. 2025-02-13;():.

Advancing Research Transparency and Reproducibility in Pharmacoepidemiology.
pmid: 39948333
doi: 10.1002/pds.70096
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Wang SV
      type: Person
      first name: Shirley V
      last name: Wang
      member of: Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts, USA.Department of Msedicine, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 2
    item: Pottegård A
      type: Person
      first name: Anton
      last name: Pottegård
      member of: Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02
dp: 2025 Feb
created: 2025-2-13T23:28
e ISSN: 1099-1557
has issn l: 1053-8569
issue: 2
has NLM journal title abbreviation: Pharmacoepidemiol Drug Saf
publication name: Pharmacoepidemiology and drug safety
language: eng
has national library of medicine journal id: 9208369
derived from: NLM
pg: e70096
has place of publication: England
source: Pharmacoepidemiol Drug Saf. 2025-02;34(2):e70096.
volume: 34

Can pigments of different natures interfere with the cytotoxicity from in-office bleaching?
pmid: 39948329
abstract: To assess the influence of tooth stained with different colored solutions on the cytotoxicity of a 35% H2O2-bleaching gel.The established groups were (n = 8): NC- without treatment (negative control); PC- 35% H2O2 (positive control); CO- coffee + 35% H2O2; BT- black tea + 35% H2O2; WI- wine + 35% H2O2; COBTWI- coffee/black tea/wine + 35% H2O2. Standardized enamel/dentin disks were submitted to staining protocols, adapted to artificial pulp chambers, and bleaching was performed. The chromatic alterations (ΔE00, ΔWID) were assessed after bleaching and the extracts (culture medium + diffused gel components) were collected and applied to odontoblast-like cells. The amount of diffused H2O2, cell viability, and oxidative stress were evaluated and data were submitted to ANOVA/Tukey; p < 0.05).Thirty five% H2O2 effectively bleached the stained specimens, regardless of the staining solution used (CO, BT, WI, and COBTWI), and no differences were found among the stained protocols (p > 0.05). All staining protocols reduced H2O2 trans-amelodentinal diffusion (p > 0.05), decreasing bleaching cytotoxicity in comparison to PC (p < 0.05).Irrespective of the nature of the pigment used for staining enamel and dentin, the gel with 35% H2O2 effectively bleached the tooth structure. The presence of pigments in both dental tissues, regardless their nature, reduced the trans-amelodentinal diffusion of H₂O₂ and consequently the cytotoxicity of the bleaching gel.
rights: © 2025. The Author(s), under exclusive licence to The Society of The Nippon Dental University.
has PII: 10.1007/s10266-025-01068-7
doi: 10.1007/s10266-025-01068-7
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: de Oliveira Ribeiro RA
      type: Person
      first name: Rafael Antonio
      last name: de Oliveira Ribeiro
      member of: Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 2
    item: Martins BV
      type: Person
      first name: Beatriz Voss
      last name: Martins
      member of: Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 3
    item: Dias MF
      type: Person
      first name: Marlon Ferreira
      last name: Dias
      member of: Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 4
    item: Peruchi V
      type: Person
      first name: Victória
      last name: Peruchi
      member of: Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 5
    item: Anselmi C
      type: Person
      first name: Caroline
      last name: Anselmi
      member of: Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 6
    item: Soares IPM
      type: Person
      first name: Igor Paulino Mendes
      last name: Soares
      member of: Department of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 7
    item: Hebling J
      type: Person
      first name: Josimeri
      last name: Hebling
      member of: Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
  slot:
    index: 8
    item: Cavalli V
      type: Person
      first name: Vanessa
      last name: Cavalli
      member of: Department of Restorative Dentistry, Piracicaba School of Dentistry, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.
  slot:
    index: 9
    item: de Souza Costa CA
      type: Person
      first name: Carlos Alberto
      last name: de Souza Costa
      member of: Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá, 1680, Araraquara, São Paulo, 14801-903, Brazil. cas.costa@unesp.br.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:28
e ISSN: 1618-1255
has issn l: 1618-1247
has NLM journal title abbreviation: Odontology
publication name: Odontology
language: eng
has national library of medicine journal id: 101134822
derived from: NLM
has place of publication: Japan
source: Odontology. 2025-02-13;():.

Academic Coaching to Promote Self-Directed Learning in Graduate Medical Education.
pmid: 39948332
abstract: Graduate medical education is a critical period for fostering self-directed learning (SDL). This study introduced an academic coaching program to support SDL among internal medicine (IM) residents, leveraging Gallimore and Tharp's four-stage model as a scaffolding framework.To assess the impact of academic coaching on residents' performance, including Internal Medicine In-Training Examination (IM-ITE) scores, individualized learning plans (ILPs), and attitudinal changes. The study also explored how coaching influenced SDL within the residency program.A mixed-methods case study was conducted in a mid-sized university's IM residency program. Quantitative measures included pre- and post-coaching surveys, ILP analysis, and IM-ITE score evaluation. Semi-structured interviews provided qualitative insights into participant experiences. Of 77 eligible residents, 40 enrolled in the coaching program, and 27 (18 post-graduate year (PGY) 1 and PGY2) completed at least one session. Baseline IM-ITE scores guided enrollment for mandatory participants.Of the 77 residents, 51 had complete IM-ITE data and individualized learning plans (ILPs) from 2022 and 2023. Residents attending one coaching session demonstrated significant improvement in IM-ITE percentile scores (p = .022), while those with two or more sessions showed significant gains in both percent correct (p = .015) and percentile scores (p = .003). No significant differences were observed in ILPs or attitudinal surveys. Qualitative analyses of resident participant interviews highlight coaching's positive influence on SDL, organized into input, process, and output domains.Sustained coaching, defined as two or more coaching meetings, is associated with improved IM-ITE performance. Qualitative findings underscore the program's role in enhancing residents' SDL.
rights: © 2025. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
has PII: 10.1007/s11606-025-09424-7
doi: 10.1007/s11606-025-09424-7
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Burtson KM
      type: Person
      first name: Kathryn M
      last name: Burtson
      member of: Wright Patterson Medical Center, Wright Patterson AFB, OH, USA. Kathryn.burtson@gmail.com.Department of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USA. Kathryn.burtson@gmail.com.Department of Health Profession Education, Uniformed Services University, Bethesda, MD, USA. Kathryn.burtson@gmail.com.
  slot:
    index: 2
    item: Wilson KR
      type: Person
      first name: Kelsey R
      last name: Wilson
      member of: Wright Patterson Medical Center, Wright Patterson AFB, OH, USA.Department of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USA.Department of Health Profession Education, Uniformed Services University, Bethesda, MD, USA.
  slot:
    index: 3
    item: Kiger ME
      type: Person
      first name: Michelle E
      last name: Kiger
      member of: Department of Health Profession Education, Uniformed Services University, Bethesda, MD, USA.Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton, OH, USA.
  slot:
    index: 4
    item: Jung E
      type: Person
      first name: Eulho
      last name: Jung
      member of: Department of Health Profession Education, Uniformed Services University, Bethesda, MD, USA.
  slot:
    index: 5
    item: Hartzell JD
      type: Person
      first name: Joshua D
      last name: Hartzell
      member of: Department of Health Profession Education, Uniformed Services University, Bethesda, MD, USA.
  slot:
    index: 6
    item: Meyer H
      type: Person
      first name: Holly
      last name: Meyer
      member of: Department of Health Profession Education, Uniformed Services University, Bethesda, MD, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:28
e ISSN: 1525-1497
has issn l: 0884-8734
has NLM journal title abbreviation: J Gen Intern Med
publication name: Journal of general internal medicine
language: eng
has national library of medicine journal id: 8605834
derived from: NLM
has place of publication: United States
source: J Gen Intern Med. 2025-02-13;():.

Immediate heart rate changes in late preterm infants receiving resuscitation in the delivery room.
pmid: 39948353
abstract: Assess heart rate (HR) trends in the minutes following delivery in late preterm infants 34-36 6/7 weeks with spontaneous respirations and compare trends in infants with delayed transition requiring interventions and assess the direct potential impact of these interventions on HR changes.Prospective observational single center study in 20 late preterm infants born via cesarean section utilizing the NeoBeat which uses dry electrode technology to obtain blinded HR measures in infants with spontaneous respirations versus infants requiring interventions i.e.: positive pressure ventilation, continuous positive airway pressure or suctioning.Initial HR in spontaneously breathing infants (n = 8) was higher versus those requiring interventions, differences that persisted through five minutes. Iatrogenic bradycardia ranging from 65 to 90 beats/minute was induced by interventions in five(42%) of 12 infants.Initial HR in spontaneously breathing late preterm infants was significantly higher compared to infants who received interventions. Respiratory interventions induced sudden unanticipated bradycardia in many cases.
rights: © 2025. The Author(s), under exclusive licence to Springer Nature America, Inc.
has PII: 10.1038/s41372-025-02220-5
doi: 10.1038/s41372-025-02220-5
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Davydova Y
      type: Person
      first name: Yafa
      last name: Davydova
      member of: Department of Pediatrics, Division of Neonatology Weill Cornell Medicine, NewYork-Presbyterian Hospital New York, New York, NY, USA.
  slot:
    index: 2
    item: Elachi D
      type: Person
      first name: Dina
      last name: Elachi
      member of: Department of Pediatrics, Division of Neonatology Weill Cornell Medicine, NewYork-Presbyterian Hospital New York, New York, NY, USA.
  slot:
    index: 3
    item: Miller R
      type: Person
      first name: Rebecca
      last name: Miller
      member of: Department of Pediatrics, Division of Neonatology Weill Cornell Medicine, NewYork-Presbyterian Hospital New York, New York, NY, USA.
  slot:
    index: 4
    item: Thomas C
      type: Person
      first name: Charlene
      last name: Thomas
      member of: Department of Healthcare Policy & Research/Division of Biostatistics & Epidemiology, New York, NY, USA.
  slot:
    index: 5
    item: Oxford C
      type: Person
      first name: Corrina
      last name: Oxford
      member of: Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
  slot:
    index: 6
    item: Perlman J
      type: Person
      first name: Jeffrey
      last name: Perlman
      member of: Department of Pediatrics, Division of Neonatology Weill Cornell Medicine, NewYork-Presbyterian Hospital New York, New York, NY, USA. Jmp2007@med.cornell.edu.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:30
e ISSN: 1476-5543
has issn l: 0743-8346
has NLM journal title abbreviation: J Perinatol
publication name: Journal of perinatology : official journal of the California Perinatal Association
language: eng
has national library of medicine journal id: 8501884
derived from: NLM
has place of publication: United States
source: J Perinatol. 2025-02-13;():.

Upper airway obstruction during sleep in infants with laryngomalacia is frequently sleep-position-dependent.
pmid: 39948383
abstract: Laryngomalacia is the most common congenital airway anomaly causing breathing difficulties in infants. Severe laryngomalacia is often associated with obstructive sleep apnea (OSA).We re-evaluated 14-year pediatric sleep center polysomnography (PSG) data in infants with fluoroscopy-verified laryngomalacia.The study included 79 infants, with a median corrected age of 8 weeks (interquartile range, IQR 5-13) and a laryngomalacia clinical score of 10/14 (IQR 7-11). Most (78%) PSG studies were daytime studies. In PSG, laryngomalacia-related breathing difficulty appeared as a sleep stage and position-dependent OSA with laborious breathing. PSG allowed position comparison in 69 infants. In the supine sleeping position, a median obstructive apnea and hypopnea-index (OAHI) was 22 h-1 (IQR 10-50) compared with 7 h-1 (IQR 1-26) in the side sleeping position (p < 0.0001). In the supine, breathing was also more laborious, and end-tidal carbon dioxide 99th percentile levels were higher than in the side sleeping position (p < 0.0001). The degree of OSA (OAHI) showed only a weak correlation with the laryngoscopy severity score (R2 0.10, p = 0.005).In infant laryngomalacia, the degree of upper airway obstruction is frequently more severe in the supine than in the side sleeping position. However, some variability remains in the response.Laryngomalacia is the most common congenital airway anomaly causing breathing difficulties in infants. Obstructive breathing events and obstructive sleep apnea are common in severe laryngomalacia even though the stridor often diminishes or resolves during sleep. We observed that in young infants with laryngomalacia, the appearance of upper airway obstruction is both sleep position and sleep-stage dependent. Compared to the supine sleeping position, the side sleeping position reduced the frequency of obstructive events and breathing effort, and lowered end-tidal carbon dioxide 99th percentile levels.
rights: © 2025. The Author(s).
has PII: 10.1038/s41390-025-03919-z
doi: 10.1038/s41390-025-03919-z
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kirjavainen T
      type: Person
      first name: Turkka
      last name: Kirjavainen
      member of: Department of Pediatrics, New Children's Hospital, Helsinki, Finland. turkka.kirjavainen@hus.fi.Pediatric Research Center, New Children's Hospital, University of Helsinki, Helsinki, Finland. turkka.kirjavainen@hus.fi.Children's Hospital Department of Clinical Neurophysiology and Neurological Sciences, HUS Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland. turkka.kirjavainen@hus.fi.
  slot:
    index: 2
    item: Kanerva M
      type: Person
      first name: Mervi
      last name: Kanerva
      member of: Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland.
  slot:
    index: 3
    item: Kukkola HL
      type: Person
      first name: Hanna-Leena
      last name: Kukkola
      member of: Department of Pediatrics, New Children's Hospital, Helsinki, Finland.Pediatric Research Center, New Children's Hospital, University of Helsinki, Helsinki, Finland.
  slot:
    index: 4
    item: Nokso-Koivisto J
      type: Person
      first name: Johanna
      last name: Nokso-Koivisto
      member of: Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:32
e ISSN: 1530-0447
has issn l: 0031-3998
has NLM journal title abbreviation: Pediatr Res
publication name: Pediatric research
language: eng
has national library of medicine journal id: 0100714
derived from: NLM
has place of publication: United States
source: Pediatr Res. 2025-02-13;():.

Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging.
pmid: 39948384
abstract: Retinopathy of prematurity (ROP) screening is vital for early disease detection in very premature infants but can cause physiological instability. This study compares the physiological response to binocular indirect ophthalmoscopy (BIO) with indentation and non-contact ultra-widefield (UWF) retinal imaging in non-ventilated neonates. The impact of the Dandle WRAP, a specialised swaddling aid, on UWF imaging was also assessed.This retrospective study included 86 ROP screening events in 66 non-ventilated infants aged 35.3 weeks (range 30.6-44.6). Vital signs were continuously recorded, evaluating immediate (within 15 min) and longer-term (within 12 h) physiological responses.ROP screening significantly increased heart and respiratory rates and decreased oxygen saturation within 15 min of screening. No significant differences in physiological responses were found between BIO and UWF imaging, although there was a trend towards lower maximum heart rate with UWF imaging. The Dandle WRAP did not significantly alter physiological responses but improved the ease and speed of UWF imaging.UWF imaging does not increase physiological instability compared to BIO in non-ventilated infants. Specialised swaddling aids may facilitate the imaging procedure.ROP screening can be distressing for premature infants and induce physiological instability during and after the examination. We deployed non-contact ultra-widefield retinal imaging as the default method of ROP screening and show that it induces comparable physiological responses as traditional indirect ophthalmoscopy in non-ventilated babies. Dandle WRAP swaddling facilitated handling and speed of retinal imaging. The study demonstrates that imaging-based ROP screening is safe and efficacious in non-ventilated neonates, and continuous multimodal physiological recordings can provide detailed assessment of the effects of procedures and medications.
rights: © 2025. The Author(s).
has PII: 10.1038/s41390-025-03906-4
doi: 10.1038/s41390-025-03906-4
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Purohit R
      type: Person
      first name: Ravi
      last name: Purohit
      member of: Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  slot:
    index: 2
    item: Usman F
      type: Person
      first name: Fatima
      last name: Usman
      member of: Department of Paediatrics, University of Oxford, Oxford, UK.
  slot:
    index: 3
    item: Ie A
      type: Person
      first name: Amanda
      last name: Ie
      member of: Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  slot:
    index: 4
    item: van der Vaart M
      type: Person
      first name: Marianne
      last name: van der Vaart
      member of: Department of Paediatrics, University of Oxford, Oxford, UK.
  slot:
    index: 5
    item: Robinson S
      type: Person
      first name: Shellie
      last name: Robinson
      member of: Department of Paediatrics, University of Oxford, Oxford, UK.
  slot:
    index: 6
    item: Buckle M
      type: Person
      first name: Miranda
      last name: Buckle
      member of: Department of Paediatrics, University of Oxford, Oxford, UK.
  slot:
    index: 7
    item: Baxter L
      type: Person
      first name: Luke
      last name: Baxter
      member of: Department of Paediatrics, University of Oxford, Oxford, UK.
  slot:
    index: 8
    item: Clee M
      type: Person
      first name: Michelle
      last name: Clee
      member of: Newborn Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  slot:
    index: 9
    item: Clifford A
      type: Person
      first name: Amanda
      last name: Clifford
      member of: Newborn Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  slot:
    index: 10
    item: Adams E
      type: Person
      first name: Eleri
      last name: Adams
      member of: Newborn Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  slot:
    index: 11
    item: Slater R
      type: Person
      first name: Rebeccah
      last name: Slater
      member of: Department of Paediatrics, University of Oxford, Oxford, UK.
  slot:
    index: 12
    item: Patel CK
      type: Person
      first name: Chetan K
      last name: Patel
      member of: Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  slot:
    index: 13
    item: Hartley C
      type: Person
      first name: Caroline
      last name: Hartley
      member of: Department of Paediatrics, University of Oxford, Oxford, UK. caroline.hartley@paediatrics.ox.ac.uk.
  slot:
    index: 14
    item: Xue K
      type: Person
      first name: Kanmin
      last name: Xue
      member of: Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Kanmin.xue@eye.ox.ac.uk.Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Kanmin.xue@eye.ox.ac.uk.Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Kanmin.xue@eye.ox.ac.uk.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:32
e ISSN: 1530-0447
has issn l: 0031-3998
has NLM journal title abbreviation: Pediatr Res
publication name: Pediatric research
language: eng
has national library of medicine journal id: 0100714
derived from: NLM
has place of publication: United States
source: Pediatr Res. 2025-02-13;():.

Bartter syndrome as natural experiment if furosemide (re)opens the ductus arteriosus.
pmid: 39948386
abstract: Furosemide increases renal prostaglandin synthesis and animal studies show reopening of the ductus arteriosus in rats exposed to furosemide. Nevertheless, large cohort studies in preterm infants do not support this hypothesis. Bartter syndrome, a rare genetic renal disorder with excessive fluid and salt-loss, is similar to continuous furosemide exposure. We hypothesize that Bartter syndrome could be considered as a natural experiment. Although most infants with Bartter syndrome are born prematurely, there are no cases found in literature with a patent ductus arteriosus which suggest that the contribution of furosemide to (re)opening of the ductus arteriosus in humans might be negligible.
rights: © 2025. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
has PII: 10.1038/s41390-025-03933-1
doi: 10.1038/s41390-025-03933-1
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Hundscheid T
      type: Person
      first name: Tim
      last name: Hundscheid
      member of: Radboudumc Amalia Children's Hospital, Department of Pediatrics, Division of Neonatology Internal postal code 804, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. tim.hundscheid@radboudumc.nl.
  slot:
    index: 2
    item: Schreuder MF
      type: Person
      first name: Michiel F
      last name: Schreuder
      member of: Radboudumc Amalia Children's Hospital, Department of Pediatric Nephrology Internal postal code 804, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
  slot:
    index: 3
    item: de Boode WP
      type: Person
      first name: Willem P
      last name: de Boode
      member of: Radboudumc Amalia Children's Hospital, Department of Pediatrics, Division of Neonatology Internal postal code 804, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:32
e ISSN: 1530-0447
has issn l: 0031-3998
has NLM journal title abbreviation: Pediatr Res
publication name: Pediatric research
language: eng
has national library of medicine journal id: 0100714
derived from: NLM
has place of publication: United States
source: Pediatr Res. 2025-02-13;():.

Orbital metastasis from uterine leiomyosarcoma with intracranial extension.
pmid: 39948398
has PII: 10.1038/s41433-025-03667-8
doi: 10.1038/s41433-025-03667-8
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Zeng Y
      type: Person
      first name: Yiwen
      last name: Zeng
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
  slot:
    index: 2
    item: Ye H
      type: Person
      first name: Huijing
      last name: Ye
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. yehuijing@qq.com.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:34
e ISSN: 1476-5454
has issn l: 0950-222X
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
has place of publication: England
source: Eye (Lond). 2025-02-13;():.

Mud-splattered pattern of retinal pigmentation in carrier of ocular albinism type 1.
pmid: 39948403
has PII: 10.1038/s41433-025-03702-8
doi: 10.1038/s41433-025-03702-8
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ramtohul P
      type: Person
      first name: Prithvi
      last name: Ramtohul
      member of: Department of Ophthalmology, Hospital Nord, Aix-Marseille University, Marseille, France. pramtohul@me.com.
  slot:
    index: 2
    item: Sagnard M
      type: Person
      first name: Marion
      last name: Sagnard
      member of: Department of Ophthalmology, Hospital Nord, Aix-Marseille University, Marseille, France.
  slot:
    index: 3
    item: David T
      type: Person
      first name: Thierry
      last name: David
      member of: Department of Ophthalmology, Hospital Nord, Aix-Marseille University, Marseille, France.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:34
e ISSN: 1476-5454
has issn l: 0950-222X
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
has place of publication: England
source: Eye (Lond). 2025-02-13;():.

Vitreous haemorrhage and retinal detachment secondary to acupoint BL1 acupuncture.
pmid: 39948400
has PII: 10.1038/s41433-025-03689-2
doi: 10.1038/s41433-025-03689-2
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yao B
      type: Person
      first name: Bangtao
      last name: Yao
      member of: Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, China. yaobamtao_njmu@163.com.
  slot:
    index: 2
    item: Yu H
      type: Person
      first name: Hao
      last name: Yu
      member of: Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, China.
  slot:
    index: 3
    item: Liu G
      type: Person
      first name: Gang
      last name: Liu
      member of: Department of Ophthalmology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui branch, Southeast University, Nanjing, China.
  slot:
    index: 4
    item: Pang B
      type: Person
      first name: Bin
      last name: Pang
      member of: Department of Ophthalmology, Xuzhou Cancer Hospital, Xuzhou, China. 627753749@qq.com.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:34
e ISSN: 1476-5454
has issn l: 0950-222X
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
has place of publication: England
source: Eye (Lond). 2025-02-13;():.

Fibrinous central serous chorioretinopathy with inferior bullous exudative retinal detachment: management using 532 nm micropulse subthreshold laser.
pmid: 39948399
has PII: 10.1038/s41433-025-03660-1
doi: 10.1038/s41433-025-03660-1
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Rana V
      type: Person
      first name: Vipin
      last name: Rana
      member of: Department of Ophthalmology, Command Hospital, (Eastern Command), Kolkata, India. arv_198290@yahoo.com.
  slot:
    index: 2
    item: Tripathi AN
      type: Person
      first name: Amit Nandan
      last name: Tripathi
      member of: Department of Ophthalmology, Command Hospital, (Eastern Command), Kolkata, India.
  slot:
    index: 3
    item: Goenka R
      type: Person
      first name: Ranjit
      last name: Goenka
      member of: Department of Ophthalmology, Command Hospital, (Eastern Command), Kolkata, India.
  slot:
    index: 4
    item: Kumar A
      type: Person
      first name: Ashok
      last name: Kumar
      member of: Department of Ophthalmology, Armed Forces Medical College, Pune, India.
  slot:
    index: 5
    item: Kaushik J
      type: Person
      first name: Jaya
      last name: Kaushik
      member of: Department of Ophthalmology, Military Hospital, Panagarh, India.
  slot:
    index: 6
    item: Markan A
      type: Person
      first name: Ashish
      last name: Markan
      member of: Vitreoretina and uvea services, Eye7 hospital, New delhi, India.
  slot:
    index: 7
    item: Gupta A
      type: Person
      first name: Abhishek
      last name: Gupta
      member of: Department of Ophthalmology, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:34
e ISSN: 1476-5454
has issn l: 0950-222X
has NLM journal title abbreviation: Eye (Lond)
publication name: Eye (London, England)
language: eng
has national library of medicine journal id: 8703986
derived from: NLM
has place of publication: England
source: Eye (Lond). 2025-02-13;():.

RNA-Seq analysis in macrophages infected with Trypanosoma cruzi: focus on TLR2 and TLR7, iron metabolism, and extracellular matrix biosynthesis.
pmid: 39948431
abstract: Trypanosoma cruzi is a protozoan parasite responsible for Chagas disease affecting millions globally. This parasite infects mammalian host cells, particularly macrophages. The interaction between T. cruzi and macrophages involves intricate signaling pathways mediated by pattern recognition receptors, which lead to the production of immune mediators, that are parasite-strain dependent and not completely understood.We conducted an unbiased transcriptomic analysis of the immune response in mouse macrophages 24 h post-infection with the Y strain of T. cruzi using RNA-Seq and validated and compared the results using quantitative RT-PCR in macrophages infected with the Y and the VFRA T. cruzi strains.Bioinformatics analysis of the transcriptomics results evidenced a key role of Tlr2 and Tlr7 in the immune response against the parasite that was parasite-dependent. The Tlr2 signaling was more activated with the VFRA strain and the Tlr7 with the Y strain. Gene ontology analyses predicted a blockage in iron transport mediated by clathrin and the modulation of the extracellular matrix biosynthesis which were validated by RT-qPCR. The infection with the VFRA strain provoked the inhibition of ferritin which correlates with parasite proliferation.Our study recapitulates the knowledge on the response of macrophages and provides insights on the importance of TLR2 and TLR7, the iron metabolism, and the extracellular matrix in the infected macrophage that help to understand the molecular mechanisms underlying T. cruzi infection in macrophages in strains with different virulence. These findings are crucial for identifying novel therapeutic targets and advancing strategies to combat Chagas disease.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
has PII: 8011629
doi: 10.1093/infdis/jiaf074
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Callejas-Hernández F
      type: Person
      first name: Francisco
      last name: Callejas-Hernández
      member of: Departamento de Biología Molecular, Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  slot:
    index: 2
    item: Herreros-Cabello A
      type: Person
      first name: Alfonso
      last name: Herreros-Cabello
      member of: Departamento de Biología Molecular, Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
  slot:
    index: 3
    item: Poveda C
      type: Person
      first name: Cristina
      last name: Poveda
      member of: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
  slot:
    index: 4
    item: Maza MC
      type: Person
      first name: María C
      last name: Maza
      member of: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
  slot:
    index: 5
    item: Mares JF
      type: Person
      first name: José Francisco
      last name: Mares
      member of: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.Tecnológico de Monterrey, (ITESM - PUE) Ciudad: Puebla, Puebla, Mexico.
  slot:
    index: 6
    item: Santos-Peñaloza DK
      type: Person
      first name: Diana Karolina
      last name: Santos-Peñaloza
      member of: Departamento de Biología Molecular, Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.Instituto de Investigación Sanitaria, Hospital Universitario de La Princesa, Madrid, Spain.
  slot:
    index: 7
    item: Fresno M
      type: Person
      first name: Manuel
      last name: Fresno
      member of: Departamento de Biología Molecular, Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Instituto de Investigación Sanitaria, Hospital Universitario de La Princesa, Madrid, Spain.
  slot:
    index: 8
    item: Gironès N
      type: Person
      first name: Núria
      last name: Gironès
      member of: Departamento de Biología Molecular, Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Instituto de Investigación Sanitaria, Hospital Universitario de La Princesa, Madrid, Spain.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-13T23:35
e ISSN: 1537-6613
has issn l: 0022-1899
has NLM journal title abbreviation: J Infect Dis
publication name: The Journal of infectious diseases
language: eng
has national library of medicine journal id: 0413675
derived from: NLM
has place of publication: United States
source: J Infect Dis. 2025-02-14;():.

Workshopping Depression to Effect Better Recognition.
pmid: 39948629
doi: 10.1111/bdi.70004
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Tsai GM
      type: Person
      first name: Gracie Meng-Cin
      last name: Tsai
      member of: School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan.
  slot:
    index: 2
    item: Hung CW
      type: Person
      first name: Ching-Wen
      last name: Hung
      member of: School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan.
  slot:
    index: 3
    item: Bell E
      type: Person
      first name: Erica
      last name: Bell
      member of: Academic Department of Psychiatry, Faculty of Medicine and Health, Kolling Institute, Northern Clinical School, The University of Sydney, Sydney, New South Wales, Australia.CADE Clinic and Mood-T, Royal North Shore Hospital, Northern Sydney Local Health District, St. Leonards, New South Wales, Australia.
  slot:
    index: 4
    item: Malhi G
      type: Person
      first name: Gin
      last name: Malhi
      member of: Academic Department of Psychiatry, Faculty of Medicine and Health, Kolling Institute, Northern Clinical School, The University of Sydney, Sydney, New South Wales, Australia.CADE Clinic and Mood-T, Royal North Shore Hospital, Northern Sydney Local Health District, St. Leonards, New South Wales, Australia.Department of Psychiatry, University of Oxford, Oxford, UK.Faculty of Philosophy, Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK.
  slot:
    index: 5
    item: Wu CY
      type: Person
      first name: Chia-Yi
      last name: Wu
      member of: School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan.Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan.
created: 2025-2-14T00:23
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:44
e ISSN: 1399-5618
has issn l: 1398-5647
has NLM journal title abbreviation: Bipolar Disord
publication name: Bipolar disorders
language: eng
has national library of medicine journal id: 100883596
derived from: NLM
has place of publication: Denmark
source: Bipolar Disord. 2025-02-13;():.

Leveraging Virtual Reality for Smart Content Delivery in a Special Needs Dental Clinic Curriculum.
pmid: 39948653
doi: 10.1002/jdd.13851
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kaur N
      type: Person
      first name: Noorpreet
      last name: Kaur
      member of: Department of Comprehensive Dentistry, University of Texas Health Science Center in San Antonio, San Antonio, Texas, USA.
  slot:
    index: 2
    item: Soto A
      type: Person
      first name: Annetty
      last name: Soto
      member of: Department of Comprehensive Dentistry, University of Texas Health Science Center in San Antonio, San Antonio, Texas, USA.
  slot:
    index: 3
    item: Marinkovic M
      type: Person
      first name: Milos
      last name: Marinkovic
      member of: Department of Comprehensive Dentistry, University of Texas Health Science Center in San Antonio, San Antonio, Texas, USA.
  slot:
    index: 4
    item: Challa SN
      type: Person
      first name: Suman N
      last name: Challa
      member of: Division of Dental Public Health Program, University of Texas Health Science Center in San Antonio, San Antonio, Texas, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:45
e ISSN: 1930-7837
has issn l: 0022-0337
has NLM journal title abbreviation: J Dent Educ
publication name: Journal of dental education
language: eng
has national library of medicine journal id: 8000150
derived from: NLM
has place of publication: United States
source: J Dent Educ. 2025-02-13;():.

Longevity of terminal abutment teeth retaining maxillary obturator prostheses.
pmid: 39948686
abstract: To evaluate the longevity of terminal abutment teeth retaining maxillary obturator prostheses.This was a retrospective study of patients who underwent maxillectomy followed by delivery of definitive obturator prostheses between 1994 and 2020. Details on patient demographics, primary tumor, and radiation therapy were collected. The tooth closest to the defect was identified as the terminal abutment, and information such as tooth type, condition of tooth at the time of maxillectomy, Aramany classification, and cause of abutment loss were noted from the dental charts. Survival time of the terminal abutment tooth was calculated from the date of maxillectomy to the last dental follow-up visit or the date of abutment loss. Univariate analyses were performed to test for the association between survival time and each of the four covariates.In the 26-year study period, 148 teeth in 130 patients met the inclusion criteria. Ninety-eight (66.2%) terminal abutment teeth survived, and 50 (33.8%) were lost. Squamous cell carcinoma was the leading tumor diagnosis (51%). Aramany Class II was the most predominant arch configuration (51%). The majority of the terminal abutment teeth were maxillary incisors (43%). The chief cause of terminal abutment loss was bone loss and mobility (46%). The 10-year survival probability was 65%. Radiation therapy did not statistically contribute to terminal abutment loss. Terminal abutment teeth with dental treatment showed higher failure than those without any prior treatment or dental disease.Clinicians must be aware of the various factors affecting the survival of terminal abutment teeth which can ultimately affect the success of the maxillary obturator prostheses.
rights: © 2025 by the American College of Prosthodontists.
doi: 10.1111/jopr.14026
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Chandy T
      type: Person
      first name: Tintu
      last name: Chandy
      member of: Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.Clinical Assistant Professor, Department of Prosthodontics, University of Maryland, Baltimore, Maryland, USA.
  slot:
    index: 2
    item: Singh A
      type: Person
      first name: Annu
      last name: Singh
      member of: Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  slot:
    index: 3
    item: Mishra Meza A
      type: Person
      first name: Akriti
      last name: Mishra Meza
      member of: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  slot:
    index: 4
    item: Riedel E
      type: Person
      first name: Elyn
      last name: Riedel
      member of: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  slot:
    index: 5
    item: Huryn JM
      type: Person
      first name: Joseph M
      last name: Huryn
      member of: Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  slot:
    index: 6
    item: Randazzo JD
      type: Person
      first name: Joseph D
      last name: Randazzo
      member of: Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
created: 2025-2-14T00:24
date last updated: 2025-02-13
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-13T23:46
e ISSN: 1532-849X
has issn l: 1059-941X
has NLM journal title abbreviation: J Prosthodont
publication name: Journal of prosthodontics : official journal of the American College of Prosthodontists
language: eng
has national library of medicine journal id: 9301275
derived from: NLM
has place of publication: United States
source: J Prosthodont. 2025-02-13;():.

The role of spontaneous strategy use in verbal episodic memory impairment in adult ADHD.
pmid: 39948711
abstract: Attention deficit hyperactivity disorder (ADHD) is associated with diverse cognitive deficits of which problems related to memory and learning are well-established but poorly understood. In an online experiment, we studied whether verbal memory impairment in adult ADHD is related to differences in spontaneous use of memory strategies that hinge upon metacognitive and executive skills. Eighty-one ADHD adults and 209 neurotypical controls performed a Word List Learning task where the same words were presented three times, each time coupled with an open strategy report. Bayesian analyses indicated that the ADHD group recalled less words, did not differ from controls in efficacy of strategy use, but exhibited more limited strategy use than the controls. This suggests that less versatile strategy employment, possibly related to core executive deficits, may play a role in verbal memory impairment in adults with ADHD. Concerning treatment implications, future research could probe to what extent external strategy instruction might increase the versatility of mnemonic strategy use in adult ADHD, and thereby partly compensate for their verbal memory deficits.
rights: © 2025 The British Psychological Society.
doi: 10.1111/jnp.12416
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Laine M
      type: Person
      first name: Matti
      last name: Laine
      member of: Department of Psychology, Åbo Akademi University, Turku, Finland.
  slot:
    index: 2
    item: Kunnari A
      type: Person
      first name: Anton
      last name: Kunnari
      member of: Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
  slot:
    index: 3
    item: Eräste T
      type: Person
      first name: Tilda
      last name: Eräste
      member of: Department of Psychology, Åbo Akademi University, Turku, Finland.
  slot:
    index: 4
    item: Ritakallio L
      type: Person
      first name: Liisa
      last name: Ritakallio
      member of: Department of Psychology, Åbo Akademi University, Turku, Finland.
  slot:
    index: 5
    item: Hedberg B
      type: Person
      first name: Benjamin
      last name: Hedberg
      member of: Department of Psychology, Åbo Akademi University, Turku, Finland.
  slot:
    index: 6
    item: Salmi J
      type: Person
      first name: Juha
      last name: Salmi
      member of: Unit of Psychology, Faculty of Education and Psychology, University of Oulu, Oulu, Finland.Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T00:03
e ISSN: 1748-6653
has issn l: 1748-6645
has NLM journal title abbreviation: J Neuropsychol
publication name: Journal of neuropsychology
language: eng
has national library of medicine journal id: 101468753
derived from: NLM
has place of publication: England
source: J Neuropsychol. 2025-02-13;():.

Impact of SARS-CoV-2 infection on clinical characteristics, antibody levels, and immune responses in patients with malignant hematological tumors.
pmid: 39948717
abstract: This study evaluated SARS-CoV-2 infection impacts on clinical characteristics, antibody levels, and immune responses in 100 malignant hematological tumor patients. Laboratory assessments included hematological, biochemical, and inflammatory markers. Multivariable analysis identified age (OR = 1.56, p = 0.004), chemotherapy cycles (OR = 1.86, p < 0.001), comorbidities (OR = 3.15, p = 0.015), WBC count (OR = 1.79, p = 0.016), CRP (OR = 2.07, p = 0.007), ferritin (OR = 1.22, p = 0.035), IL-6 (OR = 1.59, p = 0.001), IgG (OR = 2.28, p = 0.037), CD8+ T cells (OR = 2.97, p = 0.005), and NK cells (OR = 0.80, p = 0.019) as COVID-19 risk factors. COVID-19 patients showed significantly higher hospitalization (30.77% vs 10.42%, p = 0.007), ICU admission (23.08% vs 6.25%, p = 0.019), and lower 1-year survival (59.62% vs 87.50%, p = 0.002) versus controls. SARS-CoV-2 infection induces hematological/immune alterations and worsens clinical outcomes in hematological malignancy patients, emphasizing their heightened vulnerability.
doi: 10.1080/1120009X.2025.2458377
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Li Y
      type: Person
      first name: Yan
      last name: Li
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 2
    item: Zhang J
      type: Person
      first name: Jing
      last name: Zhang
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 3
    item: Wang X
      type: Person
      first name: Xiang
      last name: Wang
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 4
    item: Wang Y
      type: Person
      first name: Yan
      last name: Wang
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 5
    item: Wang R
      type: Person
      first name: Ruili
      last name: Wang
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 6
    item: Chen Y
      type: Person
      first name: Yongzhen
      last name: Chen
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 7
    item: Chen C
      type: Person
      first name: Changkai
      last name: Chen
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
  slot:
    index: 8
    item: Tian Y
      type: Person
      first name: Yuyang
      last name: Tian
      member of: Department of Hematology, Hainan Cancer Hospital, Haikou, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T00:03
e ISSN: 1973-9478
has issn l: 1120-009X
has NLM journal title abbreviation: J Chemother
publication name: Journal of chemotherapy (Florence, Italy)
language: eng
has national library of medicine journal id: 8907348
derived from: NLM
starting page: 1
ending page: 12
has place of publication: England
source: J Chemother. 2025-02-13;():1-12.

The Natural Progression for Nursing Practice: Competency-Based Frameworks to Entrustable Professional Activities .
pmid: 39948719
doi: 10.1111/nhs.70065
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Willetts G
      type: Person
      first name: Georgina
      last name: Willetts
      member of: Centre for Forensic Behavioural Science, Swinburne University of Technology, Hawthorn, Australia.
  slot:
    index: 2
    item: Maguire T
      type: Person
      first name: Tessa
      last name: Maguire
      member of: Centre for Forensic Behavioural Science, Swinburne University of Technology, Hawthorn, Australia.The Victorian Institute of Forensic Mental Health (Forensicare), Fairfield, Australia.Institute Health and Wellbeing, Federation University Australia, Melbourne, Victoria, Australia.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-03
dp: 2025 Mar
created: 2025-2-14T00:03
e ISSN: 1442-2018
has issn l: 1441-0745
issue: 1
has NLM journal title abbreviation: Nurs Health Sci
publication name: Nursing & health sciences
language: eng
has national library of medicine journal id: 100891857
derived from: NLM
pg: e70065
has place of publication: Australia
source: Nurs Health Sci. 2025-03;27(1):e70065.
volume: 27

Safety and Feasibility of Early Extubation in Liver Transplantation: Experience in 1555 Patients.
pmid: 39948722
abstract: Early extubation after liver transplantation can decrease cost and intensive care unit lengths of stay, but its adoption remains limited because of safety concerns. We assessed the feasibility and safety of early extubation at a liver transplant center with a high early extubation rate. We analyzed subgroups of high-risk patients, including high model for end-stage liver disease-sodium (MELD-Na) score, high intraoperative blood loss, and patients undergoing simultaneous liver-kidney transplantation.We included all adult liver transplantations performed at a single center between June 2012 and July 2022. Patients were divided into 2 groups: (1) those extubated early (ie, in the operating room or within the first hour of intensive care unit admission) and (2) those who underwent delayed extubation. The primary outcome was reintubation within 48 h after early extubation. Rates of early extubation were analyzed separately for quartiles of MELD-Na score and intraoperative blood loss.Of 1555 patients, 969 (62%) were extubated early. Of these, 31 patients (3.2%) required mechanical ventilation within 48 h postoperatively: 11 patients (1.1%) were reintubated for respiratory failure and 20 (2.1%) remained intubated after reoperation. There was no difference in postoperative pneumonia between the groups (P = 0.059). Early extubation rates inversely correlated with the quartiles of MELD-Na score and estimated blood loss. In the highest quartile for MELD-Na (>34) and estimated blood loss (>5 L), 34% of patients were extubated early.Early extubation of properly selected patients after liver transplantation is safe and associated with a low rate of reintubation, even among select groups of high-risk patients.
rights: Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 00007890-990000000-01011
doi: 10.1097/TP.0000000000005356
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Lacom C
      type: Person
      first name: Conrad
      last name: Lacom
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.Division of General Anesthesia and Intensive Care Medicine, Department of Anesthesia, Critical Care and Pain Medicine, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 2
    item: Kothari RP
      type: Person
      first name: Rishi P
      last name: Kothari
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.Department of Anesthesiology, Thomas Jefferson University, Philadelphia, PA.
  slot:
    index: 3
    item: Mendez NV
      type: Person
      first name: Nicholas V
      last name: Mendez
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
  slot:
    index: 4
    item: Galli A
      type: Person
      first name: Alessandro
      last name: Galli
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.Dipartimento di Emergenza, Azienda Socio Sanitaria Territoriale Papa Giovanni XXII, Urgenza e Area Critica, Bergamo, Italy.
  slot:
    index: 5
    item: Roll GR
      type: Person
      first name: Garrett R
      last name: Roll
      member of: Department of Surgery, University of California, San Francisco, San Francisco, CA.
  slot:
    index: 6
    item: Bokoch MP
      type: Person
      first name: Michael P
      last name: Bokoch
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
  slot:
    index: 7
    item: Legrand M
      type: Person
      first name: Matthieu
      last name: Legrand
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
  slot:
    index: 8
    item: Adelmann D
      type: Person
      first name: Dieter
      last name: Adelmann
      member of: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T00:03
e ISSN: 1534-6080
has issn l: 0041-1337
has NLM journal title abbreviation: Transplantation
publication name: Transplantation
language: eng
has national library of medicine journal id: 0132144
derived from: NLM
has place of publication: United States
source: Transplantation. 2025-02-14;():.

Setting the Stage for the Inner Journey: Unraveling the Interplay of Contextual Factors and the Intensity of Psychedelic-Induced Ego Dissolution.
pmid: 39948726
abstract: Psychedelics have the potential to induce profound alterations in cognition, emotionality, and sensory perception. The quality and intensity of these subjective effects exhibit high intra- and inter-individual variability, which can potentially be accounted for by the variability in contexts in which psychedelics are used. Therefore, the aim of the present cross-sectional study was to investigate how internal and external contextual factors are related to the subjective intensity of psychedelic-induced ego dissolution experiences. Participants completed an online survey in which they reported their motivations for past use of psychedelic substances, and the frequency of use in different environments and social contexts. Additionally, participants completed the Ego Dissolution Inventory to evaluate the intensity of past ego dissolution experiences. Robust linear regression analysis was performed on data from 862 psychedelics users (701 had used LSD and 553 had used psilocybin mushrooms); this revealed that participants consuming psychedelics for spiritual or self-healing purposes reported more intense, while those motivated by curiosity reported less intense ego dissolution experiences. However, the social context and physical environment did not exhibit robust associations with the reported ego dissolution. Therefore, our study enhances understanding of how set and setting factors relate to psychedelic-induced ego dissolution experiences in naturalistic contexts.
doi: 10.1080/02791072.2025.2464797
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Adamczyk S
      type: Person
      first name: Stanisław
      last name: Adamczyk
      member of: Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.
  slot:
    index: 2
    item: Paczyńska M
      type: Person
      first name: Małgorzata
      last name: Paczyńska
      member of: Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.
  slot:
    index: 3
    item: Ruban A
      type: Person
      first name: Anastasia
      last name: Ruban
      member of: Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.Institute of Psychology, Cardinal Stefan Wyszyński University in Warsaw, Warsaw, Poland.
  slot:
    index: 4
    item: Szczypiński J
      type: Person
      first name: Jan
      last name: Szczypiński
      member of: Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
  slot:
    index: 5
    item: Bola M
      type: Person
      first name: Michał
      last name: Bola
      member of: Centre for Brain Research, Jagiellonian University, Kraków, Poland.
  slot:
    index: 6
    item: Orłowski P
      type: Person
      first name: Paweł
      last name: Orłowski
      member of: Centre for Brain Research, Jagiellonian University, Kraków, Poland.Doctoral School in the Social Sciences, Jagiellonian University, Kraków, Poland.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T00:03
e ISSN: 2159-9777
has issn l: 0279-1072
has NLM journal title abbreviation: J Psychoactive Drugs
publication name: Journal of psychoactive drugs
language: eng
has national library of medicine journal id: 8113536
derived from: NLM
starting page: 1
ending page: 12
has place of publication: United States
source: J Psychoactive Drugs. 2025-02-13;():1-12.

NOTICES.
pmid: 39948741
doi: 10.1111/jgs.19397
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:23
e ISSN: 1532-5415
has issn l: 0002-8614
issue: 2
has NLM journal title abbreviation: J Am Geriatr Soc
publication name: Journal of the American Geriatrics Society
language: eng
has national library of medicine journal id: 7503062
derived from: NLM
pg: 672
has place of publication: United States
source: J Am Geriatr Soc. 2025-02;73(2):672.
volume: 73

The gene-panel obtained by anti-PD-1 monotherapy for melanoma reveals prognostic markers and therapeutic targets.
pmid: 39948732
abstract: To search for key drug resistance biomarkers and potential chemotherapeutic agents for combination therapy in melanoma patients. The common up-regulated differentially expressed genes were acquired from two cohort studies, GSE91061 and PRJEB23709. Univariate and multivariate Cox regression survival analyses were performed to screen for important prognostic biomarkers. A multi-gene panel including APP, ARHGAP42, GSTA4 and UCHL1, not only plays an important role in prognostic indicators, but also in predicting the probability of resistance to anti-PD-1 in patients with melanoma. Chemotherapy drug response models found five potential drugs, including all-trans retinoic acid, doxorubicin, etoposide, methotrexate and MG-132, were significantly associated with target genes in gene-panel. Molecular docking confirmed that potential drugs have good binding ability to target genes APP, GSTA4 and UCHL1, suggesting that the multi-gene panel is expected to provide assistance for drug resistance prediction and prognosis assessment and combination therapy in patients with anti-PD-1 resistant melanoma.
doi: 10.1080/1120009X.2025.2465013
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wang M
      type: Person
      first name: Miaomiao
      last name: Wang
      member of: Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao, China.
  slot:
    index: 2
    item: Zhou Z
      type: Person
      first name: Zhike
      last name: Zhou
      member of: Department of Dermatology, Qingdao Municipal Hospital, Qingdao, China.
  slot:
    index: 3
    item: Wang Y
      type: Person
      first name: Yingying
      last name: Wang
      member of: Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao, China.
  slot:
    index: 4
    item: Wang L
      type: Person
      first name: Lixin
      last name: Wang
      member of: Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T00:13
e ISSN: 1973-9478
has issn l: 1120-009X
has NLM journal title abbreviation: J Chemother
publication name: Journal of chemotherapy (Florence, Italy)
language: eng
has national library of medicine journal id: 8907348
derived from: NLM
starting page: 1
ending page: 14
has place of publication: England
source: J Chemother. 2025-02-13;():1-14.

Response to Letter to Human-written versus ChatGPT-generated case reports .
pmid: 39948750
doi: 10.1111/jog.16240
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Matsubara S
      type: Person
      first name: Shigeki
      last name: Matsubara
      member of: Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan.Department of Obstetrics and Gynecology, Koga Red Cross Hospital, Ibaraki, Japan.Medical Examination Center, Ibaraki Western Medical Center, Ibaraki, Japan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:32
e ISSN: 1447-0756
has issn l: 1341-8076
issue: 2
has NLM journal title abbreviation: J Obstet Gynaecol Res
publication name: The journal of obstetrics and gynaecology research
language: eng
has national library of medicine journal id: 9612761
derived from: NLM
pg: e16240
has place of publication: Australia
source: J Obstet Gynaecol Res. 2025-02;51(2):e16240.
volume: 51

Faculty development programmes: Essential for empowering health professional educators to blend AI in medical education.
pmid: 39948772
doi: 10.47391/JPMA.25-08
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Aftab R
      type: Person
      first name: Rabia
      last name: Aftab
      member of: Anaesthesiology and DED, Aga Khan University, Karachi.
  slot:
    index: 2
    item: Sarfaraz S
      type: Person
      first name: Shaur
      last name: Sarfaraz
      member of: Department of Medical Education, Altamash Institute of Dental Medicine, Karachi.
  slot:
    index: 3
    item: Afzal A
      type: Person
      first name: Azam
      last name: Afzal
      member of: CHS and DED, Aga Khan University, Karachi, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
starting page: 179
ending page: 180
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):179-180.
volume: 75

Socionutrition: The science of socionutrients.
pmid: 39948803
abstract: Nutrients are substances used by an organism to survive, grow and reproduce. Social used in relation to companionship and society. In this opinion piece, we propose and propound a novel concept, Socionutrition, and discuss the science of socionutrients, socionutrient triggers and modifiers, as well as socionutrient abuse. We discuss these parameters in relation to health and explore their relevance to disease prevention and management.
doi: 10.47391/JPMA.25-12
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kalra S
      type: Person
      first name: Sanjay
      last name: Kalra
      member of: Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India.
  slot:
    index: 2
    item: Kalra B
      type: Person
      first name: Bharti
      last name: Kalra
      member of: Department of Obstetrics and Gynaecology, Bharti Hospital, Karnal, India.
  slot:
    index: 3
    item: Verma M
      type: Person
      first name: Madhur
      last name: Verma
      member of: Department of Family and Community Medicine, AIIMS, Bathinda, India.
  slot:
    index: 4
    item: Kapoor N
      type: Person
      first name: Nitin
      last name: Kapoor
      member of: Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India; Non-communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
starting page: 334
ending page: 337
has place of publication: Pakistan
has primary subject term: D009751
has subject term: D006801
source: J Pak Med Assoc. 2025-02;75(2):334-337.
volume: 75

Withholding diagnostic and prognostic information from patients in Pakistan: ethical and cultural perspectives.
pmid: 39948812
doi: 10.47391/JPMA.21282
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Bhatti MO
      type: Person
      first name: Muhammad Osama
      last name: Bhatti
      member of: Wah Medical College, Wah Cantonment, Rawalpindi, Pakistan.
  slot:
    index: 2
    item: Hamza A
      type: Person
      first name: Ameer
      last name: Hamza
      member of: Department of Physiotherapy, University of Lahore, Lahore, Pakistan.
  slot:
    index: 3
    item: Eman NU
      type: Person
      first name: Noor Ul
      last name: Eman
      member of: Wah Medical College, Wah Cantonment, Rawalpindi, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 358
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):358.
volume: 75

Toripalimab: A new age in fighting Nasopharyngeal Carcinoma.
pmid: 39948809
doi: 10.47391/JPMA.20757
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Siddiqui TA
      type: Person
      first name: Taha Ahmad
      last name: Siddiqui
      member of: Department of Medicine, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan.
  slot:
    index: 2
    item: Wakil A
      type: Person
      first name: Aamrah
      last name: Wakil
      member of: Department of Medicine, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan.
  slot:
    index: 3
    item: Imran M
      type: Person
      first name: Maham
      last name: Imran
      member of: Department of Medicine, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 355
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):355.
volume: 75

Trailblazer Tepezza for thyroid.
pmid: 39948808
doi: 10.47391/JPMA.20296
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Khatoon A
      type: Person
      first name: Aamna
      last name: Khatoon
      member of: Bahria University Medical and Dental College, Karachi, Pakistan.
  slot:
    index: 2
    item: Ahmed FK
      type: Person
      first name: Fatima Kaleem
      last name: Ahmed
      member of: Bahria University Medical and Dental College, Karachi, Pakistan.
  slot:
    index: 3
    item: Ahmed AK
      type: Person
      first name: Amna Kaleem
      last name: Ahmed
      member of: 4th Year MBBS Student, Jinnah Medical and Dental College, Karachi, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 354
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):354.
volume: 75

Preoperative risk assessment scores for Difficult Laparoscopic cholecystectomydo we need them in Pakistan?
pmid: 39948811
doi: 10.47391/JPMA.21259
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Parvez A
      type: Person
      first name: Amna
      last name: Parvez
      member of: Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  slot:
    index: 2
    item: Ansari M
      type: Person
      first name: Mehreen
      last name: Ansari
      member of: Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 357
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):357.
volume: 75

Concerns and Considerations Regarding Azithromycin Use by Physicians.
pmid: 39948810
doi: 10.47391/JPMA.20896
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Arain NR
      type: Person
      first name: Nimra Razaque
      last name: Arain
      member of: South City Hospital, Karachi, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 356
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):356.
volume: 75

Use of metformin in treatment of dengue fever.
pmid: 39948816
doi: 10.47391/JPMA.20931
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Irfan Z
      type: Person
      first name: Zainab
      last name: Irfan
      member of: Third Year MBBS Student, Ziauddin University, Karachi, Pakistan.
  slot:
    index: 2
    item: Yaqub HZ
      type: Person
      first name: Hasan Zia
      last name: Yaqub
      member of: Third Year MBBS Student, Ziauddin University, Karachi, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 365
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):365.
volume: 75

Making semaglutide accessible in Pakistan: A crucial step for heart failure treatment.
pmid: 39948813
doi: 10.47391/JPMA.21483
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Sattar S
      type: Person
      first name: Saqib
      last name: Sattar
      member of: Wah Medical College, Wah Cantt, Rawalpindi, Pakistan.
  slot:
    index: 2
    item: Sattar K
      type: Person
      first name: Khansa
      last name: Sattar
      member of: 3rd Year MBBS Student, Rawalpindi Medical University, Rawalpindi, Pakistan.
  slot:
    index: 3
    item: Tanveer R
      type: Person
      first name: Rahman
      last name: Tanveer
      member of: 3rd Year MBBS Student, Punjab Medical College, Faisalabad Medical University, Faisalabad, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
starting page: 359
ending page: 360
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):359-360.
volume: 75

Student-run free clinics (SRFCs) can solve three problems for Pakistan.
pmid: 39948820
doi: 10.47391/JPMA.21126
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Ahmad B
      type: Person
      first name: Bashir
      last name: Ahmad
      member of: Final Year MBBS Student, Northwest School of Medicine, Peshawar, Pakistan.
  slot:
    index: 2
    item: Wazir R
      type: Person
      first name: Rabia
      last name: Wazir
      member of: Final Year MBBS Student, Northwest School of Medicine, Peshawar, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 368
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):368.
volume: 75

More than just a broken limb: Unmasking CRPS in Pakistan.
pmid: 39948817
doi: 10.47391/JPMA.21043
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Khan ZA
      type: Person
      first name: Zahra Aamir
      last name: Khan
      member of: 3rd Year MBBS Student, Bahria University of Health Sciences, Karachi, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 366
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):366.
volume: 75

Waiting areas in tertiary-care hospitals in Pakistan, a major risk for airborne infections.
pmid: 39948822
doi: 10.47391/JPMA.21321
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Lund MS
      type: Person
      first name: Muhammad Shahwaiz
      last name: Lund
      member of: 4th Year MBBS Student, Allama Iqbal Medical College Affiliated with University of Health Sciences, Lahore, Pakistan.
  slot:
    index: 2
    item: Ishaq MU
      type: Person
      first name: Muhammad Uzair
      last name: Ishaq
      member of: Department of Medicine, Allama Iqbal Medical College Affiliated with University of Health Sciences, Lahore, Pakistan.
  slot:
    index: 3
    item: Nawaz M
      type: Person
      first name: Moeen
      last name: Nawaz
      member of: Department of Medicine, Allama Iqbal Medical College Affiliated with University of Health Sciences, Lahore, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 372
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):372.
volume: 75

Optimizing iron absorption: Superiority of alternate day dosing.
pmid: 39948818
doi: 10.47391/JPMA.21109
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Rafique MU
      type: Person
      first name: Muhammad Umar
      last name: Rafique
      member of: 4th Year MBBS Student, CMH Lahore Medical College, National University of Medical Sciences, Lahore, Pakistan.
  slot:
    index: 2
    item: Asghar A
      type: Person
      first name: Ayeeza
      last name: Asghar
      member of: 4th Year MBBS Student, CMH Lahore Medical College, National University of Medical Sciences, Lahore, Pakistan.
  slot:
    index: 3
    item: Ahmad A
      type: Person
      first name: Abdullah
      last name: Ahmad
      member of: CMH Lahore Medical College, National University of Medical Sciences, Lahore, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 367
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):367.
volume: 75

Cost-Related medication non-adherence in Pakistan: a pervasive public health challenge.
pmid: 39948815
doi: 10.47391/JPMA.20817
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Iqbal Khan MF
      type: Person
      first name: Muhammad Fahad
      last name: Iqbal Khan
      member of: Second Year MBBS Student, Khyber Medical College, Peshawar, Pakistan.
  slot:
    index: 2
    item: Shah Khan IM
      type: Person
      first name: Izhar Muhammad
      last name: Shah Khan
      member of: Second Year MBBS Student, Khyber Medical College, Peshawar, Pakistan.
  slot:
    index: 3
    item: Khan S
      type: Person
      first name: Shahzaib
      last name: Khan
      member of: Second Year MBBS Student, Khyber Medical College, Peshawar, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 364
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):364.
volume: 75

Capvaxive (V116): A new frontier in the prevention of pneumococcal pneumonia and invasive disease.
pmid: 39948821
doi: 10.47391/JPMA.21318
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Wijdan SA
      type: Person
      first name: Syed Ali
      last name: Wijdan
      member of: 3rd Year MBBS Student, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
  slot:
    index: 2
    item: Mustafa M
      type: Person
      first name: Muhammad
      last name: Mustafa
      member of: 3rd Year MBBS Student, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
starting page: 370
ending page: 371
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):370-371.
volume: 75

The Crucial Role of Gut Microbiome in Cardiovascular Health.
pmid: 39948823
doi: 10.47391/JPMA.21392
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Abid H
      type: Person
      first name: Hiba
      last name: Abid
      member of: 1st Year MBBS Student, Jinnah Sindh Medical University, Karachi, Pakistan.
  slot:
    index: 2
    item: Maheshwari P
      type: Person
      first name: Parena
      last name: Maheshwari
      member of: 1st Year MBBS Student, Jinnah Sindh Medical University, Karachi, Pakistan.
  slot:
    index: 3
    item: Abid A
      type: Person
      first name: Areeba
      last name: Abid
      member of: 1st Year MBBS Student, Jinnah Sindh Medical University, Karachi, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 373
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):373.
volume: 75

Misuse of sedative hypnotics: A call to awareness.
pmid: 39948819
doi: 10.47391/JPMA.21110
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Abdullah G
      type: Person
      first name: Ghazi
      last name: Abdullah
      member of: Final Year MBBS Student, Nishtar Medical University, Multan, Pakistan.
  slot:
    index: 2
    item: Zafar A
      type: Person
      first name: Areesha
      last name: Zafar
      member of: Final Year MBBS Student, Nishtar Medical University, Multan, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T00:53
ISSN: 0030-9982
has issn l: 0030-9982
issue: 2
has NLM journal title abbreviation: J Pak Med Assoc
publication name: JPMA. The Journal of the Pakistan Medical Association
language: eng
has national library of medicine journal id: 7501162
derived from: NLM
pg: 368
has place of publication: Pakistan
source: J Pak Med Assoc. 2025-02;75(2):368.
volume: 75

[A Case of Gastric Cancer Diagnosed from Ovarian Metastasis and Underwent Laparoscopic Proximal Gastrectomy after Neoadjuvant Chemotherapy].
pmid: 39948846
abstract: The prognosis of patients with gastric cancer and ovarian metastasis is extremely poor, with many studies reporting survival durations within 1-2 years after diagnosis. The patient in this study was a 64-year-old female who visited a local hospital with lower abdominal pain and was referred to our hospital's gynecology department for follow-up of uterine fibroids. MRI revealed a right ovarian tumor and upper gastrointestinal endoscopy revealed gastric cancer in the upper stomach. A total hysterectomy with bilateral adnexectomy was performed, and the pathological examination revealed that gastric cancer had metastasized to the uterus and right ovary. After SOX therapy, laparoscopic proximal gastrectomy with double-flap reconstruction was performed. Postoperative pathological diagnosis was U, Ant, pType 5, 38×21 mm, por-tub, ypT4a(SE), Ly1b, V0(VB), ypPM0, ypDM0, ypN0, P0, CY0, H0, M1(OTH), ypStage Ⅳ, R0. Two years and 10 months have passed since the surgery, and there have been no signs of recurrence. In this patient, both the ovarian metastasis and primary gastric lesion were completely resected, and chemotherapy was effective, resulting in a good prognosis. Considering that gastrectomy reduces chemotherapy tolerability, the timing of gastrectomy should be considered. In addition, avoiding total gastrectomy is important for postoperative adjuvant chemotherapy.
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Watanabe M
      type: Person
      first name: Megumi
      last name: Watanabe
      member of: Dept. of Surgery, National Hospital Organization Iwakuni Clinical Center.
  slot:
    index: 2
    item: Nosaka M
      type: Person
      first name: Mikoto
      last name: Nosaka
  slot:
    index: 3
    item: Mohri K
      type: Person
      first name: Kengo
      last name: Mohri
  slot:
    index: 4
    item: Sato M
      type: Person
      first name: Maho
      last name: Sato
  slot:
    index: 5
    item: Miyake E
      type: Person
      first name: Eiki
      last name: Miyake
  slot:
    index: 6
    item: Kajioka H
      type: Person
      first name: Hiroki
      last name: Kajioka
  slot:
    index: 7
    item: Ogawa T
      type: Person
      first name: Toshihiro
      last name: Ogawa
  slot:
    index: 8
    item: Taniguchi F
      type: Person
      first name: Fumitaka
      last name: Taniguchi
  slot:
    index: 9
    item: Arata T
      type: Person
      first name: Takashi
      last name: Arata
  slot:
    index: 10
    item: Katsuda K
      type: Person
      first name: Kou
      last name: Katsuda
  slot:
    index: 11
    item: Tanakaya K
      type: Person
      first name: Kohji
      last name: Tanakaya
  slot:
    index: 12
    item: Aoki H
      type: Person
      first name: Hideki
      last name: Aoki
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2024-12
dp: 2024 Dec
created: 2025-2-14T01:01
ISSN: 0385-0684
has issn l: 0385-0684
issue: 13
has NLM journal title abbreviation: Gan To Kagaku Ryoho
publication name: Gan to kagaku ryoho. Cancer & chemotherapy
language: jpn
has national library of medicine journal id: 7810034
derived from: NLM
starting page: 1330
ending page: 1332
has place of publication: Japan
has primary subject term: D013274Q000175Q000188Q000556Q000601
has primary subject term: D010051Q000000981Q000473
has primary subject term: D005743
has primary subject term: D020360
has subject term: D006801
has subject term: D005260
has subject term: D008279
has subject term: D016099
has subject term: D009362
source: Gan To Kagaku Ryoho. 2024-12;51(13):1330-1332.
volume: 51

[A Case of Resection of Brain Metastasis from Pancreatic Tail Cancer with Multiple Lung and Liver Metastases].
pmid: 39948930
abstract: The patient is a 66-year-old man. He came to the hospital for chest and back pain, and a CT scan of the chest and abdomen showed the pancreatic tail cancer and multiple lung and liver metastases. Systemic chemotherapy was performed, but during the course of the treatment, he had difficulty in speaking, and a head MRI scan was performed, which led to suspicion of brain metastasis of pancreatic cancer. At this point, the primary tumor and lung liver metastases were well controlled by chemotherapy, so brain tumor resection was performed. Postoperatively, the patient had slight residual aphasia, tinnitus, and mild hearing loss, but the patient did not develop any other symptoms. After that, multiple bone metastases were discovered, and from then on, the patient received mainly palliative care, and died from the underlying disease 57 months after the initial diagnosis and 20 months after brain tumor surgery. No intracerebral recurrence was observed during the course of treatment. Pancreatic cancer with brain metastasis is rare, no treatment has been established, and its prognosis is extremely poor. Surgical resection of metastatic brain tumors in pancreatic cancer may improve the prognosis when the primary tumor and other metastases are well controlled.
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Nakaie R
      type: Person
      first name: Ryoichi
      last name: Nakaie
      member of: Dept. of Surgery, Shinyukuhashi Hospital.
  slot:
    index: 2
    item: Yamashita S
      type: Person
      first name: Shingo
      last name: Yamashita
  slot:
    index: 3
    item: Kurogi J
      type: Person
      first name: Junpei
      last name: Kurogi
  slot:
    index: 4
    item: Nabeshima M
      type: Person
      first name: Masanori
      last name: Nabeshima
  slot:
    index: 5
    item: Kabeya S
      type: Person
      first name: Shiro
      last name: Kabeya
  slot:
    index: 6
    item: Ishii T
      type: Person
      first name: Takahiro
      last name: Ishii
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2024-12
dp: 2024 Dec
created: 2025-2-14T01:01
ISSN: 0385-0684
has issn l: 0385-0684
issue: 13
has NLM journal title abbreviation: Gan To Kagaku Ryoho
publication name: Gan to kagaku ryoho. Cancer & chemotherapy
language: jpn
has national library of medicine journal id: 7810034
derived from: NLM
starting page: 1578
ending page: 1580
has place of publication: Japan
has primary subject term: D001932Q000000981Q000556
has primary subject term: D010190Q000000981Q000473
has primary subject term: D008175Q000000981Q000556
has primary subject term: D008113Q000000981Q000556
has subject term: D006801
has subject term: D008297
has subject term: D000368
has subject term: D014057
has subject term: D017809
source: Gan To Kagaku Ryoho. 2024-12;51(13):1578-1580.
volume: 51

The impact of red cell storage age on transfused patients with sickle cell disease: protocol of a pilot randomized clinical trial to evaluate changes in inflammation and clinical transfusion efficacy.
pmid: 39949021
abstract: Despite fulfilling all requirements for donor blood units as defined by the FDA, a number of patients with sickle cell disease (SCD) are transfused with red blood cell (RBC) units that are near the end of their storage life, exposing them to the potentially adverse components of the red cell storage lesion. Due to their chronically inflamed state, patients with SCD may be particularly susceptible to these components. We present here a pilot study protocol for testing the impact of fresh vs older red cell units in chronically transfused adults with SCD.This is a randomized, prospective, clinical trial. We aimed to recruit forty chronically transfused adults or adolescents with SCD who receive regular RBC transfusions for their clinical care and randomize these patients to receive either units greater than or equal to 30 days, or units less than or equal to 10 days for 3 consecutive outpatient transfusion events.The primary endpoint is the metabolic differences identified between units transfused that are greater than or equal to 30 days, and those units less than or equal to 10 days. The secondary endpoint evaluates the change in blood monocyte activation at 2 hours after transfusion between the two groups. Lastly, weevaluate unit RBC efficacy via changes in hemoglobin/day, hemoglobin A%/day, hospitalization rate, pain scores, and infections as documented via blood and urine cultures.This study promises to provide evidence as to whether metabolically older red cell units affect the quality and efficacy of chronic transfusion therapy for adults with SCD and has the potential to guide the need for future study on this important clinical issue.
has PII: BloodTransfus.886
doi: 10.2450/BloodTransfus.886
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Karafin MS
      type: Person
      first name: Matthew S
      last name: Karafin
      member of: Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.
  slot:
    index: 2
    item: Fasano RM
      type: Person
      first name: Ross M
      last name: Fasano
      member of: Center for Transfusion Medicine and Cellular Rerapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
  slot:
    index: 3
    item: Illich A
      type: Person
      first name: Anton
      last name: Illich
      member of: Division of Hematology and Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  slot:
    index: 4
    item: Wichlan D
      type: Person
      first name: David
      last name: Wichlan
      member of: Division of Hematology and Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  slot:
    index: 5
    item: Chang A
      type: Person
      first name: Ada
      last name: Chang
      member of: Division of Hematology and Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  slot:
    index: 6
    item: James SM
      type: Person
      first name: Sonjile M
      last name: James
      member of: Center for Transfusion Medicine and Cellular Rerapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
  slot:
    index: 7
    item: Butler HE
      type: Person
      first name: Hailly E
      last name: Butler
      member of: Center for Transfusion Medicine and Cellular Rerapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
  slot:
    index: 8
    item: Kolupaev O
      type: Person
      first name: Oleg
      last name: Kolupaev
      member of: Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States of America.
  slot:
    index: 9
    item: Caughey MC
      type: Person
      first name: Melissa C
      last name: Caughey
      member of: Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, North Carolina, United States of America.
  slot:
    index: 10
    item: Key NS
      type: Person
      first name: Nigel S
      last name: Key
      member of: Division of Hematology and Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  slot:
    index: 11
    item: Field JJ
      type: Person
      first name: Joshua J
      last name: Field
      member of: Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
  slot:
    index: 12
    item: Little JA
      type: Person
      first name: Jane A
      last name: Little
      member of: Division of Hematology and Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-04
dp: 2025 Feb 04
created: 2025-2-14T01:02
e ISSN: 2385-2070
has issn l: 1723-2007
has NLM journal title abbreviation: Blood Transfus
publication name: Blood transfusion = Trasfusione del sangue
language: eng
has national library of medicine journal id: 101237479
derived from: NLM
has place of publication: Italy
source: Blood Transfus. 2025-02-04;():.

Combination of Evans syndrome and COVID-19: a systematic review of reported cases.
pmid: 39949024
abstract: Evans syndrome is a rare autoimmune disease characterized by simultaneous or sequential primary immune thrombocytopenia and autoimmune hemolytic anemia. Despite the low incidence of Evans syndrome after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, its progression may threaten public health. This review offers an up-to-date summary of the works on the association between coronavirus disease 2019 (COVID-19) and Evans syndrome to explore the pathogenic mechanisms, epidemiological characteristics, clinical presentations, diagnostic markers, and treatment strategies.We searched PubMed and Web of Science to identify articles that explored the relationship between COVID-19 and Evans syndrome. We collected and organized all reported cases of Evans syndrome following COVID-19 or SARS-CoV-2 vaccination over the past 4 years and also expanded the search to examine other cases of post-infection Evans syndrome.Thirteen cases were included with an average age of 42 years of whom 12 survived and one died. Two cases were associated with pregnancy and four with vaccination, two involved epileptic seizures, and three had a history of autoimmune disease.Patients with Evans syndrome and exposure to SARS-CoV-2 have a potential risk of bleeding. This risk should prompt close monitoring of bleeding biomarker dynamics and early initiation of hemostatic treatments, including platelet transfusion, corticosteroids, thrombopoietin receptor agonists, intravenous immunoglobulin and rituximab.
has PII: BloodTransfus.860
doi: 10.2450/BloodTransfus.860
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Li S
      type: Person
      first name: Suwen
      last name: Li
      member of: Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 2
    item: Li R
      type: Person
      first name: Ranran
      last name: Li
      member of: Department of Radiology, Ningjin County People's Hospital, Dezhou, China.
  slot:
    index: 3
    item: Li Y
      type: Person
      first name: Yuyao
      last name: Li
      member of: Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.School of Clinical Medicine, Shandong First Medical University, Jinan, China.
  slot:
    index: 4
    item: Hu Y
      type: Person
      first name: Yuefen
      last name: Hu
      member of: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
  slot:
    index: 5
    item: Liu Y
      type: Person
      first name: Yan
      last name: Liu
      member of: Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 6
    item: Qin J
      type: Person
      first name: Jing
      last name: Qin
      member of: School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
  slot:
    index: 7
    item: Qin Z
      type: Person
      first name: Zizhen
      last name: Qin
      member of: Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
  slot:
    index: 8
    item: Feng Q
      type: Person
      first name: Qi
      last name: Feng
      member of: Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 9
    item: Sheng Z
      type: Person
      first name: Zi
      last name: Sheng
      member of: Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 10
    item: Li C
      type: Person
      first name: Chaoyang
      last name: Li
      member of: Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 11
    item: Peng J
      type: Person
      first name: Jun
      last name: Peng
      member of: Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment, Qilu Hospital of Shandong University, Jinan, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-06
dp: 2025 Feb 06
created: 2025-2-14T01:02
e ISSN: 2385-2070
has issn l: 1723-2007
has NLM journal title abbreviation: Blood Transfus
publication name: Blood transfusion = Trasfusione del sangue
language: eng
has national library of medicine journal id: 101237479
derived from: NLM
has place of publication: Italy
source: Blood Transfus. 2025-02-06;():.

Validation of manually scored multichannel frontal electroencephalography against polysomnography in a paediatric cohort.
pmid: 39949045
abstract: Polysomnography is the only internationally recognized method to diagnose paediatric obstructive sleep apnea, thus, simpler and more cost-effective diagnostic tools are urgently needed. This study aimed to validate the manual scoring of frontal self-applicable electroencephalography against polysomnography in a paediatric cohort. The polysomnography and the frontal electroencephalography were simultaneously recorded for 1 night (n = 102) in 10-13-year-old children. Scoring was performed according to the American Academy of Sleep Medicine rules, with minor adjustments to the frontal electroencephalography. Manual scorings of sleep stages were compared in an epoch-by-epoch manner using Cohen's kappa (κ) and confusion matrices using three different models: the three-stage (wake/non-rapid eye movement/rapid eye movement), the four-stage (wake/sleep stage 1 + sleep stage 2/deep sleep Stage 3/rapid eye movement) and the five-stage model (wake/sleep stage 1/sleep stage 2/deep sleep Stage 3/rapid eye movement). The inter-scorer agreements were assessed, and the intraclass correlation coefficient was used for common sleep variables: total sleep time, wake after sleep onset, sleep efficiency, sleep-onset latency and arousal index. Cohen's κ values for the three-stage, four-stage and five-stage models were 0.85, 0.73 and 0.70, respectively. The agreement for the sleep variables studied ranged from 0.87 to 0.99. The inter-rater agreement (n = 10) was κ = 0.78 for the polysomnography and κ = 0.70 for the frontal electroencephalography. Sleep staging from the frontal electroencephalography was comparable to that of a standard polysomnography in a paediatric cohort, and showed promising results in estimating sleep time and sleep architecture.
rights: © 2025 The Author(s). Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
doi: 10.1111/jsr.70012
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Sigurdardottir S
      type: Person
      first name: Sigridur
      last name: Sigurdardottir
      member of: Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
  slot:
    index: 2
    item: Pitkänen H
      type: Person
      first name: Henna
      last name: Pitkänen
      member of: Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
  slot:
    index: 3
    item: Korkalainen H
      type: Person
      first name: Henri
      last name: Korkalainen
      member of: Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
  slot:
    index: 4
    item: Kainulainen S
      type: Person
      first name: Samu
      last name: Kainulainen
      member of: Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
  slot:
    index: 5
    item: Serwatko M
      type: Person
      first name: Marta
      last name: Serwatko
      member of: Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
  slot:
    index: 6
    item: Olafsdottir KA
      type: Person
      first name: Kristin A
      last name: Olafsdottir
      member of: Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
  slot:
    index: 7
    item: Sigurðardóttir SÞ
      type: Person
      first name: Sigurveig Þ
      last name: Sigurðardóttir
      member of: Department of Immunology, Landspitali University Hospital, Reykjavik, Iceland.University of Iceland, Faculty of Medicine, Reykjavik, Iceland.
  slot:
    index: 8
    item: Clausen M
      type: Person
      first name: Michael
      last name: Clausen
      member of: Children's Hospital Reykjavik, Reykjavik, Iceland.Department of Allergy, Landspitali University Hospital, Reykjavik, Iceland.
  slot:
    index: 9
    item: Somaskandhan P
      type: Person
      first name: Pranavan
      last name: Somaskandhan
      member of: School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, Queensland, Australia.
  slot:
    index: 10
    item: Stražišar BG
      type: Person
      first name: Barbara G
      last name: Stražišar
      member of: Paediatric Department, Centre for Paediatric Sleep Disorders, General Hospital Celje, Celje, Slovenia.Medical Faculty, University of Maribor, Maribor, Slovenia.
  slot:
    index: 11
    item: Leppänen T
      type: Person
      first name: Timo
      last name: Leppänen
      member of: Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, Queensland, Australia.
  slot:
    index: 12
    item: Arnardottir ES
      type: Person
      first name: Erna Sif
      last name: Arnardottir
      member of: Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.Internal Medicine Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T01:23
e ISSN: 1365-2869
has issn l: 0962-1105
has NLM journal title abbreviation: J Sleep Res
publication name: Journal of sleep research
language: eng
has national library of medicine journal id: 9214441
derived from: NLM
pg: e70012
has place of publication: England
source: J Sleep Res. 2025-02-13;():e70012.

Robot-Assisted Gait Training in Older Patients with Comorbid Conditions: A Pilot Study.
pmid: 39949050
abstract: This study aimed to evaluate the efficacy of robot-assisted gait training (RAGT) in older patients with neurological gait disorder accompanied by various comorbidities.We included Individuals aged ≥65 years with degenerative brain diseases or stroke causing gait disorders for >6 months in open-label, a pilot study. RAGT was performed for 30 min/day, 2 days/week for 12 weeks. The intensity was set to 60% of the individual's heart rate maximum reserve. Primary outcome measures were the Timed Up and Go (TUG) test and Berg Balance Scale (BBS). Secondary outcomes included Beck Depression Inventory (BDI), Short Form-36 (SF-36), and evaluation of satisfaction.Thirteen participants completed 24 sessions. Neurological diseases included stroke (n = 7) and Parkinson's disease (n = 6); all patients had at least two other diseases. After RAGT, TUG test results significantly improved, and BBS scores increased. Furthermore, BDI scores decreased, and scores of social functioning and mental health domain in the SF-36 increased. Participants rated high scores on satisfaction of RAGT.Our finding showed that RAGT is a safe and effective intervention for enhancing physical function, improving quality of life, and reducing depression levels in older patients with neurological gait disorder accompanied by various comorbidities.
doi: 10.1080/0361073X.2025.2459546
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Choi SI
      type: Person
      first name: Seung Ick
      last name: Choi
      member of: Department of Rehabilitation Medicine, Yongin Severance Hospital, Yongin, Republic of Korea.Department of Integrative Medicine Major in Digital Healthcare, Yonsei University College of Medicine, Seoul, Republic of Korea.
  slot:
    index: 2
    item: Lim SJ
      type: Person
      first name: So Jeong
      last name: Lim
      member of: Department of Rehabilitation Medicine, Yongin Severance Hospital, Yongin, Republic of Korea.
  slot:
    index: 3
    item: Kim NY
      type: Person
      first name: Na Young
      last name: Kim
      member of: Department of Rehabilitation Medicine, Yongin Severance Hospital, Yongin, Republic of Korea.Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T01:23
e ISSN: 1096-4657
has issn l: 0361-073X
has NLM journal title abbreviation: Exp Aging Res
publication name: Experimental aging research
language: eng
has national library of medicine journal id: 7603335
derived from: NLM
starting page: 1
ending page: 13
has place of publication: United States
source: Exp Aging Res. 2025-02-13;():1-13.

Immuno-epidemiologic mapping of HLA diversity across glioma patient cohorts.
pmid: 39949048
abstract: Individual-level characteristics underlying population-level variation in glioma risk and outcomes remain incompletely understood. Cancer immunosurveillance, host immunity, and some immunotherapies center on the ability of an individual's immune cells to recognize antigen epitopes presented on MHC molecules. Inter-individual variation in HLA alleles can elicit distinct repertoires of tumor antigen for presentation to immune cells. Therefore, HLA alleles may impact glioma incidence and prognosis.HLA class I (HLA-I) alleles were identified using sequencing data from four large glioma cohorts and healthy cohorts, matched on ancestry, and race- and age-matched imputed cohorts developed by the Hardy-Weinberg equilibrium were referred to determine odds ratio incidence estimated by logistic regression. HLA prognostication was quantified by Cox regression.We analyzed 1,215 cases of glioma patients from non-Hispanic Whites and Asians. The HLA-I allelic frequencies of gliomas generally corresponded to their distribution within each race. However, specific HLA-I alleles were significantly associated with glioma incidence and prognosis, which differ between races but were independent of age and sex. Notably, non-Hispanic White glioma patients exhibited greater HLA homozygosity rates compared with race-matched controls. HLA-C01:02 and HLA-C07:02 displayed opposing effects on glioma prognosis between races. The distinct effects were associated with their capability of presenting specific mutations that appeared at the initial or late phase of glioma progression.Expression of specific HLA-I alleles are associated with glioma incidence and prognosis within race. HLA-I-homozygosity is a risk factor for glioma in non-Hispanic Whites. These findings may guide development of precision-guided immunotherapies for glioma.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 8011766
doi: 10.1093/neuonc/noaf040
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Xiong Z
      type: Person
      first name: Zujian
      last name: Xiong
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.Xiangya School of Medicine, Central South University, Changsha, Hunan, China.Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  slot:
    index: 2
    item: Walsh KM
      type: Person
      first name: Kyle M
      last name: Walsh
      member of: Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC, USA.
  slot:
    index: 3
    item: Sneiderman CT
      type: Person
      first name: Chaim T
      last name: Sneiderman
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.The Ohio State University, Columbus, OH, USA.
  slot:
    index: 4
    item: Nisnboym M
      type: Person
      first name: Michal
      last name: Nisnboym
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel.
  slot:
    index: 5
    item: Hadjipanayis CG
      type: Person
      first name: Costas G
      last name: Hadjipanayis
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 6
    item: Agnihotri S
      type: Person
      first name: Sameer
      last name: Agnihotri
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 7
    item: Eagar TN
      type: Person
      first name: Todd N
      last name: Eagar
      member of: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.Immunogenetics and Transplantation Laboratory Houston Methodist, Houston, TX, United States.
  slot:
    index: 8
    item: Wang H
      type: Person
      first name: Hong
      last name: Wang
      member of: Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 9
    item: Pollack IF
      type: Person
      first name: Ian F
      last name: Pollack
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 10
    item: Forsthuber TG
      type: Person
      first name: Thomas G
      last name: Forsthuber
      member of: Department of Molecular Microbiology and Immunology, University of Texas at San Antonio, San Antonio, TX, USA.
  slot:
    index: 11
    item: Li X
      type: Person
      first name: Xuejun
      last name: Li
      member of: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, China.
  slot:
    index: 12
    item: Raphael I
      type: Person
      first name: Itay
      last name: Raphael
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 13
    item: Kohanbash G
      type: Person
      first name: Gary
      last name: Kohanbash
      member of: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T01:23
e ISSN: 1523-5866
has issn l: 1522-8517
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
has place of publication: England
source: Neuro Oncol. 2025-02-14;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39949051
pmid: 39949051
abstract: Clinical data on the efficacy and safety of the dual delayed-release formulation of 10-mg esomeprazole (HIP2101) are currently limited. Therefore, this study compared the efficacy and safety of HIP2101 and 20-mg famotidine (RLD2101) in patients with gastric erosions.In this multicenter, randomized, double-blind, active-control, phase III study, 326 patients with endoscopically proven gastric mucosal erosion were randomly assigned to receive either HIP2101 or RLD2101 once daily for 2 weeks. The primary endpoint was the rate of improvement of erosion. Secondary endpoints (rate of cure of erosion and edema, and rate of improvement of hematin and gastrointestinal symptoms) and treatment-emergent adverse events were compared between the groups.Based on the per-protocol set (PPS) analysis, the improvement rates for erosion were 64.9% (98/151) and 63.7% (100/157) in the HIP2101 and RLD2101 groups, respectively (95% confidence interval, -9.5 to 11.9). The lower bound of the 95% confidence interval was greater than the noninferiority margin of -14%. These results were similar to those of the full analysis set (FAS) (HIP2101 group, 64.6%; RLD2101 group, 62.7%). Based on the PPS and FAS analyses, the cure rates for erosion and edema and the improvement rates for hematin and gastrointestinal symptoms were comparable between the groups. The number of adverse events did not differ significantly between the groups.The efficacy and safety of HIP2101 were comparable to those of RLD2101 in the treatment of gastric erosions and symptomatic improvement. These findings suggest that HIP2101 may be a novel treatment option for gastritis (ClinicalTrials.gov identifier: NCT05024721).
has PII: gnl240390
doi: 10.5009/gnl240390
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Lim H
      type: Person
      first name: Hyun
      last name: Lim
      member of: Department of Internal Medicine, Hallym University Sacred Heart Hospital, University of Hallym College of Medicine, Anyang, Korea.
  slot:
    index: 2
    item: Lee JY
      type: Person
      first name: Ju Yup
      last name: Lee
      member of: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  slot:
    index: 3
    item: Kwon YH
      type: Person
      first name: Yong Hwan
      last name: Kwon
      member of: Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
  slot:
    index: 4
    item: Moon HS
      type: Person
      first name: Hee Seok
      last name: Moon
      member of: Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
  slot:
    index: 5
    item: Park JK
      type: Person
      first name: Jong Kyu
      last name: Park
      member of: Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
  slot:
    index: 6
    item: Kim KB
      type: Person
      first name: Ki Bae
      last name: Kim
      member of: Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
  slot:
    index: 7
    item: Kim SW
      type: Person
      first name: Sang Wook
      last name: Kim
      member of: Department of Internal Medicine, Jeonbuk National University Hospital, Jeonju, Korea.
  slot:
    index: 8
    item: Youn YH
      type: Person
      first name: Young Hoon
      last name: Youn
      member of: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  slot:
    index: 9
    item: Kim SG
      type: Person
      first name: Sang Gyun
      last name: Kim
      member of: Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  slot:
    index: 10
    item: Kim GH
      type: Person
      first name: Gwang Ha
      last name: Kim
      member of: Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Pusan, Korea.
  slot:
    index: 11
    item: Kim JW
      type: Person
      first name: Ji Won
      last name: Kim
      member of: Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
  slot:
    index: 12
    item: Jang JY
      type: Person
      first name: Jae-Young
      last name: Jang
      member of: Department of Gastroenterology and Hepatology, College of Medicine, Kyung Hee University, Seoul, Korea.
  slot:
    index: 13
    item: Kwon KS
      type: Person
      first name: Kye Sook
      last name: Kwon
      member of: Division of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
  slot:
    index: 14
    item: Kwon JG
      type: Person
      first name: Joong Goo
      last name: Kwon
      member of: Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
  slot:
    index: 15
    item: Kim HS
      type: Person
      first name: Hyun-Soo
      last name: Kim
      member of: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
  slot:
    index: 16
    item: Hong SJ
      type: Person
      first name: Su Jin
      last name: Hong
      member of: Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
  slot:
    index: 17
    item: Lee KJ
      type: Person
      first name: Kwang Jae
      last name: Lee
      member of: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
  slot:
    index: 18
    item: Choi SC
      type: Person
      first name: Suck Chei
      last name: Choi
      member of: Department of Gastroenterology, Digestive Disease Research Institute, Wonkwang University Hospital, Iksan, Korea.
  slot:
    index: 19
    item: Moon JS
      type: Person
      first name: Jeong Seop
      last name: Moon
      member of: Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
  slot:
    index: 20
    item: Kim N
      type: Person
      first name: Nayoung
      last name: Kim
      member of: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  slot:
    index: 21
    item: Park JJ
      type: Person
      first name: Jong-Jae
      last name: Park
      member of: Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  slot:
    index: 22
    item: Lim Y
      type: Person
      first name: Yirang
      last name: Lim
      member of: Hanmi Pharmaceutical Co., Ltd, Seoul, Korea.
  slot:
    index: 23
    item: Hong SH
      type: Person
      first name: Sung Hee
      last name: Hong
      member of: Hanmi Pharmaceutical Co., Ltd, Seoul, Korea.
  slot:
    index: 24
    item: Jung HY
      type: Person
      first name: Hwoon-Yong
      last name: Jung
      member of: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T01:33
e ISSN: 2005-1212
has issn l: 1976-2283
has NLM journal title abbreviation: Gut Liver
publication name: Gut and liver
language: eng
has national library of medicine journal id: 101316452
derived from: NLM
has place of publication: Korea (South)
source: Gut Liver. 2025-02-14;():.
title: Evaluation of the Efficacy and Safety of a Dual Delayed-Release Formulation of 10-mg Esomeprazole in Patients with Gastric Erosions: A Multicenter, Randomized, Double-Blind, Active-Control, Phase III Study.

Pro-Inflammatory Cytokines in Aqueous Humor From ADAMTS10-Mutant Beagles at an Early Stage of Open-Angle Glaucoma.
pmid: 39949047
abstract: To investigate the level of pro-inflammatory cytokines in aqueous humor from ADAMTS10-mutant research Beagles at an early stage of open-angle glaucoma (OAG).Twenty-four research Beagles were enrolled into this case-controlled study. Three groups of ADAMTS10-mutant research Beagles were enrolled in this study: (1) Intraocular pressure (IOP) 15-25 mmHg (normotensive IOP), (2) IOP 25-30 mmHg, and (3) IOP 30-36 mmHg. An unaffected control group of Beagles that were either ADAMTS10-wildtype (WT) or heterozygote-carrier with normotensive IOPs were also enrolled.Aqueous humor samples were collected and analyzed for 16 pro-inflammatory cytokines using the Canine Cytokine SpikeMix and target mass spectrometry via multiple reaction monitoring (MRM-MS). Statistical differences between the four groups' pro-inflammatory cytokines, as well as correlations between pro-inflammatory cytokines and IOPs, were analyzed using Kruskal-Wallis tests and Spearman's rho (ρ) correlations, respectively.IOP 15-25 mmHg (n = 8); IOP 25-30 mmHg (n = 6); IOP 30-36 mmHg (n = 5); and Control (WT n = 3, carrier n = 2, total n = 5). There were no differences between pro-inflammatory cytokines across the four groups (all p-values > 0.05). IL-13 had a moderate positive correlation with IOP, but was non-significant (ρ = 0.373, p = 0.073); IL-1β had a moderate negative correlation with IOP but was also non-significant (ρ = -0.344, p = 0.100). All other pro-inflammatory cytokines had only mild correlation with IOPs (|ρ| < 0.229, p > 0.05).There were no significant changes in the investigated pro-inflammatory cytokines with elevated IOP in canine ADAMTS10-OAG.
rights: © 2025 American College of Veterinary Ophthalmologists.
doi: 10.1111/vop.13321
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Collins E
      type: Person
      first name: Elisabeth
      last name: Collins
      member of: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
  slot:
    index: 2
    item: Harman CD
      type: Person
      first name: Christine D
      last name: Harman
      member of: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
  slot:
    index: 3
    item: Jacobson AL
      type: Person
      first name: Amanda L
      last name: Jacobson
      member of: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
  slot:
    index: 4
    item: Mehaffy C
      type: Person
      first name: Carolina
      last name: Mehaffy
      member of: Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
  slot:
    index: 5
    item: Love KR
      type: Person
      first name: Kim R
      last name: Love
      member of: KR Love Quantitative Consulting and Collaboration, Athens, Georgia, USA.
  slot:
    index: 6
    item: Komáromy AM
      type: Person
      first name: András M
      last name: Komáromy
      member of: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
  slot:
    index: 7
    item: de Linde Henriksen M
      type: Person
      first name: Michala
      last name: de Linde Henriksen
      member of: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T01:23
e ISSN: 1463-5224
has issn l: 1463-5216
has NLM journal title abbreviation: Vet Ophthalmol
publication name: Veterinary ophthalmology
language: eng
has national library of medicine journal id: 100887377
derived from: NLM
has place of publication: England
source: Vet Ophthalmol. 2025-02-13;():.

Tradition-Aware Chaplaincy Theory (TACT): A Name Change for and Evolution of Religiously Informed, Relationally Skillful Chaplaincy Theory.
pmid: 39949086
abstract: Religiously Informed, Relationally Skillful Chaplaincy Theory (RIRSCT) (Ragsdale & Desjardins, 2020) is a chaplaincy theory positing that healthcare chaplains would be more helpful to patients and to members of the healthcare team if they were better versed in how patients' religious beliefs and practices impacted their healthcare experience. Changing the theory's name to Tradition-Aware Chaplaincy Theory expands the original theory to include spiritualities and secular belief systems not included in the term Religiously Informed.
doi: 10.1177/15423050251319359
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Ragsdale JR
      type: Person
      first name: Judith R
      last name: Ragsdale
      member of: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 2167-776X
has issn l: 1542-3050
has NLM journal title abbreviation: J Pastoral Care Counsel
publication name: The journal of pastoral care & counseling : JPCC
language: eng
has national library of medicine journal id: 101144384
derived from: NLM
pg: 15423050251319359
has place of publication: United States
source: J Pastoral Care Counsel. 2025-02-13;():15423050251319359.

Improving quality of physical function assessment in intensive care units through routine use of the Danish Chelsea Critical Care Physical Assessment Tool (CPAx-D).
pmid: 39949089
abstract: To improve the quality of physical function assessment through routine use of the Chelsea Critical Care Physical Assessment Tool (CPAx-D) in Danish ICUs.The methodological framework was The Model for Improvement, including the Plan-Do-Study-Act (PDSA) cycle. The context consisted of two ICUs at Aarhus University Hospital with 38 beds. Eligible patients were aged 18 years or older and considered stable and ready for physiotherapy treatment. Evaluation methods used were questionnaires, clinical practice observations, continuous feedback, status meetings, and an audit of the medical records including patients during a three-month period in the ICUs.The quality improvement process required three PDSA cycles and two years before CPAx-D was successfully implemented into clinical practice. The following barriers were identified; the COVID-19 pandemic increased workloads and caused reorganization of care; leave of absence of the project manager caused a lack of leadership; local instructions were not sufficiently aligned with practice; and detailed manuals were missing. A facilitator for implementation was the clinicians' perception of CPAx-D as a meaningful tool, adding value to interdisciplinary collaboration and communication, and stimulated patient motivation.By employing various interventions, routine use of CPAx-D has been successfully implemented into clinical practice at two Danish ICUs.
doi: 10.1080/09638288.2025.2463629
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Astrup K
      type: Person
      first name: Katrine
      last name: Astrup
      member of: Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark.Department of Public Health, Faculty of Health, Aarhus University, Aarhus, Denmark.
  slot:
    index: 2
    item: Rolving N
      type: Person
      first name: Nanna
      last name: Rolving
      member of: Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark.Department of Public Health, Faculty of Health, Aarhus University, Aarhus, Denmark.
  slot:
    index: 3
    item: Sørensen L
      type: Person
      first name: Lotte
      last name: Sørensen
      member of: Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark.Department of Public Health, Faculty of Health, Aarhus University, Aarhus, Denmark.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1464-5165
has issn l: 0963-8288
has NLM journal title abbreviation: Disabil Rehabil
publication name: Disability and rehabilitation
language: eng
has national library of medicine journal id: 9207179
rights holder: Early rehabilitation is crucial to reduce the physical consequences of intensive care admission.Routine use of standardized assessment instruments can support goal-setting, communication, and decision-making in rehabilitation of patients in the intensive care unit.This quality improvement study outlines the barriers and facilitators identified throughout the process of implementing routine use of the Chelsea Critical Care Physical Assessment Tool.
derived from: NLM
starting page: 1
ending page: 8
has place of publication: England
source: Disabil Rehabil. 2025-02-13;():1-8.

Transient Receptor Potential Ankyrin 1 (TRPA1) Mediates Hydrogen Sulfide-induced Ca2+ Entry and Nitric Oxide Production in Human Cerebrovascular Endothelium.
pmid: 39949092
abstract: The gasotransmitter hydrogen sulfide (H2S) modulates various brain functions, including neuron excitability, synaptic plasticity, and Ca2+ dynamics. Furthermore, H2S may stimulate nitric oxide (NO) release from cerebrovascular endothelial cells, thereby regulating NO-dependent endothelial functions, such as angiogenesis, vasorelaxation, and cerebral blood flow (CBF). However, the signaling pathway by which H2S induces NO release from cerebrovascular endothelial cells is still unclear.Herein, we exploited single-cell imaging of intracellular Ca2+, H2S, and NO levels to assess how H2S induces Ca2+-dependent NO release from the human cerebrovascular endothelial cell line, hCMEC/D3.Administration of the H2S donor, sodium hydrosulfide (NaHS), induced a dose-dependent increase in (Ca2+)i only in the presence of extracellular Ca2+. NaHS-induced extracellular Ca2+ entry was mediated by the Ca2+-permeable TRPA1 channel, as shown by pharmacological and genetic manipulation of the TRPA1 protein. Furthermore, NaHS-dependent TRPA1 activation led to NO release that was abolished by buffering the concomitant increase in (Ca2+)i and inhibiting eNOS. Furthermore, the endothelial agonist, adenosine trisphosphate (ATP), caused a long-lasting elevation in (Ca2+)i that was driven by cystathionine γ-lyase (CSE)-dependent H2S production and by TRPA1 activation. Consistent with this, ATP-induced NO release was strongly reduced either by blocking CSE or by inhibiting TRPA1.These findings demonstrate for the time that H2S stimulates TRPA1 to induce NO production in human brain microvascular endothelial cells. Additionally, they show that this signaling pathway can be recruited by an endothelial agonist to modulate NO-dependent events at the human neurovascular unit.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CN-EPUB-146661
doi: 10.2174/011570159X349872250124124612
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Soda T
      type: Person
      first name: Teresa
      last name: Soda
      member of: Department of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  slot:
    index: 2
    item: Brunetti V
      type: Person
      first name: Valentina
      last name: Brunetti
      member of: Laboratory of General Physiology, Department of Biology and Biotechnology L. Spallanzani , University of Pavia, 27100 Pavia, Italy.
  slot:
    index: 3
    item: De Sarro G
      type: Person
      first name: Giovambattista
      last name: De Sarro
      member of: Department of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  slot:
    index: 4
    item: Biella G
      type: Person
      first name: Gerardo
      last name: Biella
      member of: Laboratory of General Physiology, Department of Biology and Biotechnology L. Spallanzani , University of Pavia, 27100 Pavia, Italy.
  slot:
    index: 5
    item: Moccia F
      type: Person
      first name: Francesco
      last name: Moccia
      member of: Department of Medicine and Health Sciences V. Tiberio , University of Molise, 86100 Campobasso, Italy.
  slot:
    index: 6
    item: Berra-Romani R
      type: Person
      first name: Roberto
      last name: Berra-Romani
      member of: Department of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, 72410 Puebla, Mexico.
  slot:
    index: 7
    item: Scarpellino G
      type: Person
      first name: Giorgia
      last name: Scarpellino
      member of: Laboratory of General Physiology, Department of Biology and Biotechnology L. Spallanzani , University of Pavia, 27100 Pavia, Italy.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6190
has issn l: 1570-159X
has NLM journal title abbreviation: Curr Neuropharmacol
publication name: Current neuropharmacology
language: eng
has national library of medicine journal id: 101157239
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Neuropharmacol. 2025-02-13;():.

Circulating Biomarkers as a Window into the Relationship between Sarcopenia and Diabetes: Implications for Effective Management.
pmid: 39949094
abstract: This study aims to investigate the relationship between sarcopenia and circulating biomarkers in diabetes, with a focus on early detection and effective management strategies.A literature review was conducted using the ScienceDirect, Scopus, PubMed, and Web of Science databases up to December 2024. Key search terms included diabetes, sarcopenia, HbA1c , glucose, insulin, and specific biomarkers such as inflammatory markers, adipokines, and myokines.Aging is associated with a decline in organ and bodily system functionality, with sarcopenia being particularly prominent due to its progressive loss of muscle mass and function. This condition increases health risks and mortality in the elderly. Muscles, as the primary consumers of glucose, play a crucial role in glucose uptake; reduced mass can exacerbate insulin resistance. Sarcopenia and diabetes share common pathophysiological mechanisms, including insulin resistance, inflammation, and vascular complications. Circulating biomarkers, crucial for diabetes management, may offer insights into the early stages of sarcopenia.The complex relationship between sarcopenia and diabetes, influenced by shared pathophysiological pathways, presents challenges in geriatric healthcare. Circulating biomarkers hold promise for early detection and monitoring of sarcopenia, potentially enhancing patient outcomes and quality of life. Further research is necessary to validate these connections and develop targeted treatments for individuals affected by these conditions.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CDR-EPUB-146651
doi: 10.2174/0115733998349193250207045239
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Tajik A
      type: Person
      first name: Ali
      last name: Tajik
      member of: Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  slot:
    index: 2
    item: Mahdavizadeh V
      type: Person
      first name: Vahid
      last name: Mahdavizadeh
      member of: Clinical Research Development Unit, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  slot:
    index: 3
    item: Hadizadeh F
      type: Person
      first name: Farzin
      last name: Hadizadeh
      member of: Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  slot:
    index: 4
    item: Shakour N
      type: Person
      first name: Neda
      last name: Shakour
      member of: Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6417
has issn l: 1573-3998
has NLM journal title abbreviation: Curr Diabetes Rev
publication name: Current diabetes reviews
language: eng
has national library of medicine journal id: 101253260
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Diabetes Rev. 2025-02-13;():.

Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking.
pmid: 39949090
abstract: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced insulin sensitivity in the body's cells, leading to persistently high blood glucose levels. Ganoderma lucidum triterpenoids, as important secondary metabolites of Ganoderma lucidum, have shown preliminary potential efficacy in the treatment of T2DM according to existing research. However, due to the structural complexity and diversity of these triterpenoid compounds, as well as the intricate interactions between their therapeutic targets and active ingredients, the precise molecular and pharmacological mechanisms remain to be further explored.In the present research, we aim to fully employ the integrated approach of network pharmacology and molecular docking methodologies, delving deeply into the potential therapeutic targets and their underlying pharmacological mechanisms in the management of T2DM via Ganoderma lucidum triterpenoids.The active compounds were sourced from prior research and the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Their potential targets were predicted with the aid of Swiss Target Prediction. Genes linked to T2DM were gathered from DisGeNET and GeneCards. Using Cytoscape, we established the network connecting active ingredients, targets, and pathways, and the target protein-protein interaction (PPI) network was created using data from the STRING database. The core targets of Ganoderma lucidum triterpenoids underwent gene enrichment analysis via DAVID. Lastly, to validate our chosen Ganoderma lucidum triterpenoids, we conducted molecular docking experiments between the compounds and their targets.A total of 53 Ganoderma lucidum triterpenoids and 116 associated targets were identified. Among these, SRC, MAPK1, MAPK3, HSP90AA1, TP53, PIK3CA, and AKT1 emerged as pivotal targets. We retrieved 447 Gene Ontology (GO) functional annotations and 153 Kyoto Encyclopedia of Genes and Genomes (KEGG) pa[cell cut: 2982 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146666
doi: 10.2174/0113816128365423250126035306
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Shi J
      type: Person
      first name: Junkai
      last name: Shi
      member of: SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
  slot:
    index: 2
    item: Chen J
      type: Person
      first name: Jialiang
      last name: Chen
      member of: SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.MabPlex International Co., Ltd, Yantai, Shandong 264000, China.
  slot:
    index: 3
    item: Cheng C
      type: Person
      first name: Chitong
      last name: Cheng
      member of: SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
  slot:
    index: 4
    item: Li W
      type: Person
      first name: Wei
      last name: Li
      member of: Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea.
  slot:
    index: 5
    item: Li M
      type: Person
      first name: Ming
      last name: Li
      member of: College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning 116044, China.
  slot:
    index: 6
    item: Ye S
      type: Person
      first name: Shuhong
      last name: Ye
      member of: SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
  slot:
    index: 7
    item: Liu Z
      type: Person
      first name: Zhaofang
      last name: Liu
      member of: SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
  slot:
    index: 8
    item: Ding Y
      type: Person
      first name: Yan
      last name: Ding
      member of: SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-13;():.

Effects of a Rosiridin against Rotenone-induced Rats' Model of Parkinson's Disease: In-vivo Study and in silico Molecular Modeling.
pmid: 39949093
abstract: The investigation aimed to study the outcome of rosiridin in Parkinson's disease (PD) induced by rotenone (ROT) in rodents.Rodents were randomized into IV groups and were induced with ROT followed by treatment with rosiridin. Group I-IV received saline as a vehicle, II-ROT (0.5 mg/kg S.C) for 28 consecutive days, III and IV- rosiridin 10 and 20 mg/kg orally with ROT. On completion of the experimental duration, behavioral investigations were carried out. Biochemical variables such as acetylcholinesterase (AChE), oxidative stress and antioxidants markers (Malondialdehyde-MDA, glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), anti-inflammatory (Interleukin-1 beta-IL-1β, IL-6, and tumor necrosis factor alpha-TNF-α), alteration in neurotransmitters (Serotonin-5-HT), norepinephrine, and dopamine-DA, along with metabolites such as 5-hydroxy indole acetic acid-5- HIAA),), mitochondrial complex I, II, IV, and caspase-3 activity were evaluated at the end of the experiment. Furthermore, molecular docking and dynamics were performed for target ligands.Rosiridin significantly restored the level of AChE, oxidative stress and antioxidants markers (MDA, GSH, SOD, and CAT), anti-inflammatory (IL-1β, IL-6, and TNF-α), alteration in neurotransmitters, mitochondrial complex I, II, IV, and caspase-3 activity. Rosiridin has a favorable negative binding affinity to AChE (-8.99 kcal/mol). The results of the molecular dynamics simulations indicate that proteins undergo a substantial change in conformational dynamics when binding to rosiridin.In this study, rosiridin may exhibit neuroprotective properties against the Parkinson's model for treating PD.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CN-EPUB-146660
doi: 10.2174/011570159X349553250126050134
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Rafeeq M
      type: Person
      first name: Misbahuddin
      last name: Rafeeq
      member of: Department of Pharmacology Faculty of Medicine, Rabigh King Abdulaziz University, Jeddah, Saudi Arabia.
  slot:
    index: 2
    item: A Al-Abbasi F
      type: Person
      first name: Fahad
      last name: A Al-Abbasi
      member of: Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  slot:
    index: 3
    item: Afzal M
      type: Person
      first name: Muhammad
      last name: Afzal
      member of: Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231 Jeddah 21442, Saudi Arabia.
  slot:
    index: 4
    item: Saad Alharbi K
      type: Person
      first name: Khalid
      last name: Saad Alharbi
      member of: Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Qassim 51452 Saudi Arabia.
  slot:
    index: 5
    item: Moglad E
      type: Person
      first name: Ehssan
      last name: Moglad
      member of: Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia.
  slot:
    index: 6
    item: D Al-Qahtani S
      type: Person
      first name: Salwa
      last name: D Al-Qahtani
      member of: Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia.
  slot:
    index: 7
    item: A Bukhari H
      type: Person
      first name: Hussam
      last name: A Bukhari
      member of: Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  slot:
    index: 8
    item: Imam F
      type: Person
      first name: Faisal
      last name: Imam
      member of: Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.School of Pharmacy, Glocal University, Saharanpur 247121, India.
  slot:
    index: 9
    item: Sayyed N
      type: Person
      first name: Nadeem
      last name: Sayyed
      member of: Glocal University, Saharanpur 247121, India School of Pharmacy India.
  slot:
    index: 10
    item: Kazmi I
      type: Person
      first name: Imran
      last name: Kazmi
      member of: Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6190
has issn l: 1570-159X
has NLM journal title abbreviation: Curr Neuropharmacol
publication name: Current neuropharmacology
language: eng
has national library of medicine journal id: 101157239
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Neuropharmacol. 2025-02-13;():.

Therapeutic Potential of Quercetin in Type 2 Diabetes Based on a Network Pharmacology Study.
pmid: 39949091
abstract: Currently, there are pharmacological treatments for type 2 diabetes (T2D), but these are ineffective. Quercetin is a flavonoid with antidiabetic properties.This research aimed to identify the molecular mechanism of Quercetin in T2D from network pharmacology.We obtained T2D-related genes from MalaCards and DisGeNET, while potential targets for Quercetin were sourced from SwissTargetPrediction and Comparative Toxicogenomics databases. The overlapping genes were identified and analyzed using ShinyGO 0.77. Subsequently, we constructed a protein-protein interaction network using Cytoscape, conducted molecular docking analyses with SwissDock, and validated the results through molecular dynamics simulation in GROMACS.Quercetin is involved in apoptotic processes and in the regulation of insulin activity, estrogen, prolactin and EGFR receptor. The key driver genes AKT1, GSK3B, SRC, IGF1R, MMP9, ESR2, PIK3R1, and MMP2 showed high concordance in the molecular docking study, and molecular dynamics showed stability between Quercetin and ESR2 and PIK3R1.Our work helps to identify the molecular mechanism and antidiabetic effect of quercetin, which needs to be studied experimentally.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-146668
doi: 10.2174/0115680266361598250212030220
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Basaldúa-Maciel V
      type: Person
      first name: Viridiana
      last name: Basaldúa-Maciel
      member of: Doctorado en Biociencias, Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México.
  slot:
    index: 2
    item: Guzmán-Flores JM
      type: Person
      first name: Juan Manuel
      last name: Guzmán-Flores
      member of: Departamento de Ciencias de la Salud, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlàn de Morelos, Jalisco, México.
  slot:
    index: 3
    item: Reyes-Chaparro A
      type: Person
      first name: Andrés
      last name: Reyes-Chaparro
      member of: Escuela Nacional de Ciencias Biologicas (ENCB) del Insituto Politécnico Nacional (IPN). Departamento de Morfología, Ciudad de México, México.
  slot:
    index: 4
    item: Martínez-Esquivias F
      type: Person
      first name: Fernando
      last name: Martínez-Esquivias
      member of: Departamento de Ciencias Pecuarias y Agricolas, Centro Universitario de Los Alto, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco México.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-13;():.

In-silico Approach to Combat Methicillin-resistant Staphylococcus aureus: Targeting RelP Protein with Inhibitor Peptide to Mitigate Drug Resistance.
pmid: 39949095
abstract: Methicillin-resistant Staphylococcus aureus (MRSA), known for its re-sistance to multiple antibiotics, has emerged as a major global health concern. It facilitates biofilm formation under stressful conditions by catalyzing the synthesis of alarmones (p)ppGpp and ppGpp. These alarmones on accumulation lead to biofilm formation and cause resistance towards antibiotics.This condition has prompted the exploration of various novel approaches and methodolo-gies to combat MRSA infections. Among these, peptide therapeutics stand out as a promising next-generation treatment option. In this study, ninety antimicrobial peptides were sourced from the anti-microbial peptide database and the other sixty-one peptide sequences were designed using the Pep-draw server. These peptide sequences were screened out using different in-silico tools. The protein-peptide molecular interaction was studied using a molecular docking and molecular dynamic simu-lation technique.Out of 151 peptide sequences, Pantocin wh-1 emerged as the most promising drug candidate. Both molecular interaction studies and molecular dynamics simulations demonstrated positive re-sults.Peptide therapeutics is a novel approach researchers are presently exploring as it pro-vides prompt significant results and promotes a new insight towards dealing with conditions like MDR. Pantocin wh-1 is a peptide drug currently listed as an accessible anti-tuberculosis peptide, and this study suggests the repurposing of this drug as a viable treatment option for MRSA infections.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CDDT-EPUB-146657
doi: 10.2174/0115701638337060250121154347
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sinoliya P
      type: Person
      first name: Priyanka
      last name: Sinoliya
      member of: Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
  slot:
    index: 2
    item: Solanki PS
      type: Person
      first name: Pooran Singh
      last name: Solanki
      member of: Birla Institute of Technology, Mesra, India.Birla Institute of Scientific Research, Jaipur, India.
  slot:
    index: 3
    item: Niraj RRK
      type: Person
      first name: Ravi Ranjan Kumar
      last name: Niraj
      member of: Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
  slot:
    index: 4
    item: Sharma V
      type: Person
      first name: Vinay
      last name: Sharma
      member of: Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6220
has issn l: 1570-1638
has NLM journal title abbreviation: Curr Drug Discov Technol
publication name: Current drug discovery technologies
language: eng
has national library of medicine journal id: 101157212
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Drug Discov Technol. 2025-02-13;():.

Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis.
pmid: 39949099
abstract: Thoracic aortic aneurysms (TAAs) are worrisome for their propensity to dissect. Previous studies have demonstrated the potential benefits of statin use, particularly with slowing aortic aneurysm growth. The aim of this meta-analysis was to consolidate existing research to ascertain if statins effectively reduce TAA growth.Multiple databases were searched to identify studies assessing TAA growth in patients on statins (cases) and those not on statins (controls). The primary outcome was TAA (ascending/ aortic arch) growth rate per year. Standard mean difference (SMD) and 95% confidence intervals (95% CI) were estimated with a random-effects model using the inverse-variance technique. We assigned I2>50% as an indicator of statistical heterogeneity. P-value <0.05 was considered significant. Data analysis was performed using SPSS v.25.0.Four studies comprising 757 cases (male 64%, mean age 65±14 years) and 1,696 controls (male 62%, mean age 61±18 years) were included. The baseline diameters of TAA for cases and controls were 40.35±8.75mm and 42.39±12.60mm, respectively. Pooled results suggested statins to be associated with slower growth of TAAs with pooled SMD -0.70 mm/year [95% CI (-1.23 - -0.16); p=0.01]. Heterogeneity statistics among 4 studies was 95%.This pooled meta-analysis showed statins as associated with slower growth of TAAs. However, given the heterogeneity of the included studies in this meta-analysis, results should be interpreted with caution.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CCR-EPUB-146656
doi: 10.2174/011573403X343512250127075044
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Kolimas AM
      type: Person
      first name: Amie Marie
      last name: Kolimas
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 2
    item: Malla G
      type: Person
      first name: Gargya
      last name: Malla
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 3
    item: Chadha A
      type: Person
      first name: Abhimanyu
      last name: Chadha
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 4
    item: Sainbayar E
      type: Person
      first name: Enkhtsogt
      last name: Sainbayar
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 5
    item: Sethi J
      type: Person
      first name: Joshua
      last name: Sethi
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 6
    item: Hindosh Z
      type: Person
      first name: Ziad
      last name: Hindosh
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 7
    item: Hadvani P
      type: Person
      first name: Priyanka
      last name: Hadvani
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 8
    item: Pham HN
      type: Person
      first name: Hoang Nhat
      last name: Pham
      member of: Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
  slot:
    index: 9
    item: Sordia J
      type: Person
      first name: Juan
      last name: Sordia
      member of: Department of Cardiology, Honor Health, Phoenix, Arizona.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6557
has issn l: 1573-403X
has NLM journal title abbreviation: Curr Cardiol Rev
publication name: Current cardiology reviews
language: eng
has national library of medicine journal id: 101261935
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Cardiol Rev. 2025-02-13;():.

Twins and Necrotizing Enterocolitis: Genetic Relevance.
pmid: 39949097
abstract: In preterm infants, necrotizing enterocolitis (NEC) is one of the most devastating complications seen in the neonatal intensive care unit (NICU), with both short- and long-term sequelae. Outcomes reported for mono- (versus di-) chorionic twins suggest an increased incidence in the monochorionic twins, usually attributed to abnormal placental vascular connections. Same sex concordance and zygosity data suggest shared genetic and environmental factors as important contributing factors to the pathogenesis of NEC. This concept is further supported by fecal microbiome data from preterm twins. However, there is also some uncertainty in these observations because studies that controlled for gestational age did not show significant differences between singletons and twins in the occurrence of NEC. This mini-review was undertaken as a critical appraisal of the published literature in terms of twin studies to establish the genetic relevance vis-àvis NEC. There is a need for further evaluation of genetic and confounding factors arising from the environment and the gut microbiome in these infants using cohorts with larger sample sizes.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPR-EPUB-146667
doi: 10.2174/0115733963369969250212072155
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Bhandari V
      type: Person
      first name: Vineet
      last name: Bhandari
      member of: Division of Neonatology, Department of Pediatrics, The Children's Regional Hospital at Cooper, Camden, NJ08103, United States.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6336
has issn l: 1573-3963
has NLM journal title abbreviation: Curr Pediatr Rev
publication name: Current pediatric reviews
language: eng
has national library of medicine journal id: 101240290
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pediatr Rev. 2025-02-13;():.

Identification of Ferroptosis-Related Prognostic Models and FDFT1 as a Potential Ferroptosis Driver in Colorectal Cancer.
pmid: 39949101
abstract: We aimed to develop Ferroptosis-Related Gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with colorectal cancer (CRC).Prediction of CRC prognosis is challenging. Ferroptosis constitutes a newly reported kind of cell death, and its association with CRC prognosis remains unexplored.This research endeavored to establish a prognostic risk signature for colorectal cancer by leveraging ferroptosis-related genes (FRGs), with the objective of refining prognostic precision in clinical settings.The clinical data and mRNA expression profiles were obtained from The Cancer Genome Atlas (TCGA) colorectal cancer cohorts. The Lasso algorithm was employed to develop the overall survival (OS) and disease-free survival (DFS) prediction models. These models were subsequently validated using independent data from GSE38832.Our research unveiled a significant difference in the expression levels of 85% of ferroptosis-related genes (FRGs) between CRC tissues and paracancer tissues. Out of these, 11 prognostic genes were pinpointed through univariate Cox analysis. By employing two models, patients were stratified into low- and high-risk groups based on predicted risk scores, which were subsequently validated as independent prognostic factors via multivariate Cox analysis. The robustness of these models was further confirmed through Receiver Operating Characteristic (ROC) curve analysis. Functional enrichment analysis indicated a predominance of cancer-associated pathways in the high-risk group, including WNT signaling, along with variations in immune status between the two risk categories. Leveraging the Connectivity Map (CMap) database, a total of sixteen potential therapeutic drugs were identified. Additionally, in vitro experiments corroborated that Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) was underexpressed in CRC and exhibited tumor suppressive properties. More specifically, FDFT1 may augment ferroptosis in CRC by mod[cell cut: 2489 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CMC-EPUB-146646
doi: 10.2174/0109298673377428250131112647
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Duan L
      type: Person
      first name: Lili
      last name: Duan
      member of: Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, 710032, China.
  slot:
    index: 2
    item: Cao L
      type: Person
      first name: Lu
      last name: Cao
      member of: Department of Biomedical Engineering, Air Force Medical University, Xi'an, 10032, China.
  slot:
    index: 3
    item: Liu J
      type: Person
      first name: Jinqiang
      last name: Liu
      member of: Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
  slot:
    index: 4
    item: Wang Z
      type: Person
      first name: Zixiang
      last name: Wang
      member of: Department of Medical Oncology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, 210000, China.
  slot:
    index: 5
    item: Liang J
      type: Person
      first name: Jie
      last name: Liang
      member of: The Eastern Theater Air Force Hospital, Nanjing, 210000, China.
  slot:
    index: 6
    item: Feng F
      type: Person
      first name: Fan
      last name: Feng
      member of: Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
  slot:
    index: 7
    item: Zhang J
      type: Person
      first name: Jian
      last name: Zhang
      member of: Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, 710032, China.Innovation Research Institute, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
  slot:
    index: 8
    item: Hong L
      type: Person
      first name: Liu
      last name: Hong
      member of: Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
  slot:
    index: 9
    item: Zheng J
      type: Person
      first name: Jianyong
      last name: Zheng
      member of: Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-533X
has issn l: 0929-8673
has NLM journal title abbreviation: Curr Med Chem
publication name: Current medicinal chemistry
language: eng
has national library of medicine journal id: 9440157
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Med Chem. 2025-02-13;():.

EGCG Mitigates Apoptosis of Lens Epithelial Cells in Age-Related Cataract via the PAK1/Cleaved Caspase-3 Pathway.
pmid: 39949100
abstract: Oxidative damage and apoptosis of lens epithelial cells (LECs) are the primary factors contributing to the development of age-related cataracts (ARC). The potential protective effects of epigallocatechin gallate (EGCG) on LECs remain unclear despite its remarkable antioxidant and anti-apoptotic properties. The aim of this study was to explore the role of serine/threonine-protein kinase (PAK1) in EGCG-mediated attenuation of H2O2-induced apoptosis of LECs in vivo and in vitro.PAK1 expression was assessed in the anterior capsule of the lens from mice and patients with and without ARC using western blotting and immunohistochemistry. Human lens epithelial B3 (HLE-B3) cells were pre-treated with EGCG+H2O2 or H2O2 only, and PAK1 expression was determined using qRT-PCR and western blotting. Apoptosis (following PAK1 overexpression or silencing) and cell survival were assessed using Hoechst 33342 staining and a cell counting Kit-8 assay, respectively. Cleaved caspase-3 was measured in transected cells, aged/young mice, and mice treated with EGCG via western blotting.PAK1 expression was significantly lower in ARC LECs than in control LECs. In HLE-B3 cells, EGCG+H2O2 treatment upregulated PAK1 mRNA and protein expression when compared with H2O2 alone. PAK1 overexpression alleviated H2O2- induced apoptosis in LECs, while low expression weakened EGCG's protective effects. PAK1 overexpression reduced cleaved caspase-3 expression in H2O2-treated cells, whereas PAK1 silencing increased its expression in EGCG+H2O2-treated cells. EGCG decreased cleaved caspase-3 expression in H2O2-treated cells. These results suggest that PAK1 inhibits cleaved caspase-3 expression, thereby enhancing EGCG's attenuation of H2O2-induced LEC apoptosis.The PAK1/cleaved caspase-3 pathway plays a key role in EGCG's protective effects on the development of ARC. This provides a new therapeutic target for the use of EGCG in preventing and treating ARC.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CMM-EPUB-146659
doi: 10.2174/0115665240334265250213064823
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Zhang Y
      type: Person
      first name: Yue
      last name: Zhang
      member of: Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China.
  slot:
    index: 2
    item: Su D
      type: Person
      first name: Dongmei
      last name: Su
      member of: Chinese Academy of Medical Sciences & Peking Union Medical College Graduate tutor（Peking Union Medical College） Beijing China.
  slot:
    index: 3
    item: Sun Z
      type: Person
      first name: Zhaoyi
      last name: Sun
      member of: Hongqi Hospital of Mudanjiang Medical University, Mudanjiang 157011,Heilongjiang, China.
  slot:
    index: 4
    item: Fu Y
      type: Person
      first name: Yanjiang
      last name: Fu
      member of: Daqing Eye Hospital, Daqing 163000, Heilongjiang, China.
  slot:
    index: 5
    item: Chen X
      type: Person
      first name: Xiaoya
      last name: Chen
      member of: Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China.
  slot:
    index: 6
    item: Hu Y
      type: Person
      first name: Yuzhu
      last name: Hu
      member of: Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China.
  slot:
    index: 7
    item: Zhang X
      type: Person
      first name: Xiao
      last name: Zhang
      member of: Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China.
  slot:
    index: 8
    item: Zheng S
      type: Person
      first name: Shunfei
      last name: Zheng
      member of: Mudanjiang Medical University, Mudanjiang, 157011, Heilongjiang, China.
  slot:
    index: 9
    item: Ma X
      type: Person
      first name: Xu
      last name: Ma
      member of: Department of Genetics, NHC Key Laboratory of Reproductive Health Engineering Technology Research, National Research Institute for Family Planning, Health Department, Beijing 100081, China.Graduate School, Peking Union Medical College, Beijing 100081, China.
  slot:
    index: 10
    item: Hu S
      type: Person
      first name: Shanshan
      last name: Hu
      member of: Hongqi Hospital of Mudanjiang Medical University, Mudanjiang 157011,Heilongjiang, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-5666
has issn l: 1566-5240
has NLM journal title abbreviation: Curr Mol Med
publication name: Current molecular medicine
language: eng
has national library of medicine journal id: 101093076
derived from: NLM
has place of publication: Netherlands
source: Curr Mol Med. 2025-02-13;():.

The Role of Immunosenescence and Inflammaging in the Susceptibility of Older Adults to SARS-CoV-2 Infection.
pmid: 39949104
abstract: COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that is one of the most significant challenges to public health over the past few years. Most people are vulnerable to SARS-CoV-2, but older adults are more vulnerable. Aging is one of the major risk factors for the detrimental consequences of COVID-19, likely due to chronic inflammation and immunosenescence, both of which are the characteristics of old age. Immunosenescence refers to the weakening of the immune system with age while inflammaging describes the low-grade chronic inflammation seen in older individuals. One key aspect of human aging is immune deficiency. During aging, our body's defense system weakens, resulting in decreased responses to infection by novel pathogens and a reduced ability to become immunized. The presence of chronic inflammation and viral infection in old age may cause several adverse unpredictable outcomes increasing the propensity and severity of the disease and requires to be considered, enabling people to better prepare for the potential consequences of this ongoing pandemic. This requires consideration so that individuals can better be prepared to address the potential consequences of this ongoing pandemic. In this review, we discuss the clinical characteristics of elderly COVID-19 patients and survey the associated molecular pathways that are pivotal for the interactions of the coronavirus and host cellular responses, including immunosenescence, inflammation, telomere attrition, impaired autophagy, mitochondrial dysfunction and alterations in major aging signaling pathways, which are crucial for the discovery of new therapeutic and preventive methods in the ongoing pandemic.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146664
doi: 10.2174/0113892010328697250210065420
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zia A
      type: Person
      first name: Aliabbas
      last name: Zia
      member of: Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
  slot:
    index: 2
    item: Sahebdel F
      type: Person
      first name: Faezeh
      last name: Sahebdel
      member of: Department of Rehabilitation Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
  slot:
    index: 3
    item: Farkhondeh T
      type: Person
      first name: Tahereh
      last name: Farkhondeh
      member of: Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
  slot:
    index: 4
    item: Pourbagher-Shahri AM
      type: Person
      first name: Ali Mohammad
      last name: Pourbagher-Shahri
      member of: Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
  slot:
    index: 5
    item: Samini F
      type: Person
      first name: Fariborz
      last name: Samini
      member of: Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  slot:
    index: 6
    item: Samarghandian S
      type: Person
      first name: Saeed
      last name: Samarghandian
      member of: Department of Medical Physiology, School of Medicine, Birjand Neyshabur University of Medical Sciences, Neyshabur, Iran.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-13;():.

Utilization of DNA Replication factor MCM2 by Cancer.
pmid: 39949096
abstract: MCM2 belongs to the microchromosome maintenance [MCM] family and plays an essential role in initiating DNA replication as well as maintaining normal cellular cycle functions. Recent research indicates that there is the abnormal expression of MCM2 in various cancers, such as breast, cervical, ovarian, lung, hepatocellular carcinoma, nephroblastoma, prostate, and pancreatic cancers, where it shows a strong link to tumorigenesis, growth, invasion, migration, and adverse prognosis. Thus, MCM2 could serve as a significant biomarker for the early identification, diagnosis, and prognostic evaluation of multiple cancers. In addition, targeting MCM2 expression may open new possibilities for a full range of cancer treatments. In this paper, the protein structure, physiological function, and carcinogenic mechanism of MCM2 were reviewed.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CCDT-EPUB-146655
doi: 10.2174/0115680096349638250117101910
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Yuan Y
      type: Person
      first name: Yuwei
      last name: Yuan
      member of: Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
  slot:
    index: 2
    item: Zeng T
      type: Person
      first name: Tian
      last name: Zeng
      member of: Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
  slot:
    index: 3
    item: Gao A
      type: Person
      first name: Anbo
      last name: Gao
      member of: Clinical Research Institute, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
  slot:
    index: 4
    item: Guan Y
      type: Person
      first name: Yang
      last name: Guan
      member of: School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
  slot:
    index: 5
    item: Zhang QF
      type: Person
      first name: Qun-Feng
      last name: Zhang
      member of: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of the University of South China, Hengyang, Hunan, China.
  slot:
    index: 6
    item: Li Y
      type: Person
      first name: Yukun
      last name: Li
      member of: Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China.
  slot:
    index: 7
    item: Tan H
      type: Person
      first name: Hui
      last name: Tan
      member of: Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
  slot:
    index: 8
    item: Zou J
      type: Person
      first name: Juan
      last name: Zou
      member of: Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1873-5576
has issn l: 1568-0096
has NLM journal title abbreviation: Curr Cancer Drug Targets
publication name: Current cancer drug targets
language: eng
has national library of medicine journal id: 101094211
derived from: NLM
has place of publication: Netherlands
source: Curr Cancer Drug Targets. 2025-02-13;():.

Efficacy of Dapagliflozin and Telmisartan Combination Therapy in Reducing Albuminuria and Inflammatory Markers in Diabetic Nephropathy: A Prospective Observational Study.
pmid: 39949102
abstract: Diabetic nephropathy, a major contributor to chronic kidney disease, is closely associated with inflammatory responses.This study aimed to evaluate the effectiveness of combination therapy with dapagliflozin and telmisartan in treating diabetic nephropathy and its effect on patient's albuminuria levels.We conducted a 12-week prospective observational study to assess diabetic nephropathy. Patients with diabetic nephropathy were treated with either dapagliflozin and telmisartan (n=92) or telmisartan alone (n=92). Measurements of waist-to-hip ratio, fasting blood glucose, hemoglobin A1c (HbA1c), blood pressure, urinary albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), uric acid, blood urea nitrogen, lipid profile, and inflammatory biomarkers, including C-C motif chemokine ligand 21 messenger RNA (CCL21 mRNA) and monocyte chemoattractant protein-1 (MCP-1), were obtained at baseline and following 12-weeks of treatment.Dapagliflozin and telmisartan combination therapy demonstrated a significant decrease in UACR compared with baseline levels (p<0.001). After treatment, the dapagliflozin and telmisartan group had significantly lower waist-to-hip ratio, fasting blood glucose, HbA1c, uric acid, total cholesterol, and low-density lipoprotein compared with the monotherapy group (p<0.05). Additionally, inflammatory biomarkers, including CCL21 mRNA and MCP-1, were substantially lower in the combination therapy group than in the monotherapy group (p<0.05).In comparison to monotherapy, combination therapy demonstrated more significant clinical effects in treating diabetic nephropathy. This combination therapy effectively controls blood glucose levels and UACR, reduces inflammatory responses, and improves kidney function recovery in diabetic nephropathy patients, thereby enhancing the overall clinical treatment outcomes for these patients.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CVP-EPUB-146670
doi: 10.2174/0115701611361265250211062540
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Chauhan S
      type: Person
      first name: Shalu
      last name: Chauhan
      member of: Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India.
  slot:
    index: 2
    item: Bhandari U
      type: Person
      first name: Uma
      last name: Bhandari
      member of: Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India.
  slot:
    index: 3
    item: Habib A
      type: Person
      first name: Anwar
      last name: Habib
      member of: Department of Medicine, Hamdard Institute of Medical Sciences & Research (HIMSR), Jamia Hamdard, New Delhi 110062, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6212
has issn l: 1570-1611
has NLM journal title abbreviation: Curr Vasc Pharmacol
publication name: Current vascular pharmacology
language: eng
has national library of medicine journal id: 101157208
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Vasc Pharmacol. 2025-02-13;():.

Counseling Andy.
pmid: 39949106
abstract: In this first-person narrative, the Dean instructs a young supervising physician to counsel a medical student about why he should not talk to patients about his religion. The essay reflects some of the emotions, ethical considerations and ambiguities that caregivers face in these situations.
doi: 10.1177/15423050251319498
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Pierce JR
      type: Person
      first name: J Rush
      last name: Pierce
      member of: Professor Emeritus (retired), University of New Mexico School of Medicine, Albuquerque, NM, USA.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 2167-776X
has issn l: 1542-3050
has NLM journal title abbreviation: J Pastoral Care Counsel
publication name: The journal of pastoral care & counseling : JPCC
language: eng
has national library of medicine journal id: 101144384
derived from: NLM
pg: 15423050251319498
has place of publication: United States
source: J Pastoral Care Counsel. 2025-02-13;():15423050251319498.

Association of Hypertensive Disorders of Pregnancy and their Clinical Features with Peripartum Cardiomyopathy: A Systematic Review and Meta-analysis.
pmid: 39949098
abstract: Peripartum Cardiomyopathy (PPCM) is a rare yet fatal cardiac disease associated with pregnancy. PPCM has been shown to have similar etiopathogenesis with hypertensive disorders of pregnancy (HDP). Hence, this study aims to study the association between HDP and the development of PPCM.Three databases (PubMed, Scopus, Cochrane Library) were searched and screened based on prespecified inclusion and exclusion criteria. Predictors of PPCM evaluated were HDP (preeclampsia, superimposed preeclampsia, chronic hypertension, and gestational hypertension) and its clinical features (severe preeclampsia, age, parity, serum creatinine, etc.). Data were analyzed using the random effects model of pooled odds ratios (ORs) with the Mantel Haenszel method, and publication bias was assessed with a funnel plot.A total of 13 observational studies with 11,951 PPCM cases from 7 countries were identified. All types of HDP were associated with significantly increased odds of developing PPCM, and severe preeclampsia was associated with the highest OR of 13.33 (CI: 5.95 - 29.83, p < 0.01). Additionally, superimposed preeclampsia, chronic hypertension, preeclampsia, and lastly gestational hypertension were associated with increased odds of PPCM with OR 5.77, 4.73, 4.70, and 3.13, respectively. Other clinical features being statistically significant for PPCM development included advanced age > 35 years and multiple pregnancies (p < 0.05). No significant difference in creatinine level was found between PPCM and no PPCM group. No publication bias was found based on funnel plot assessment.HDP, especially severe preeclampsia, is associated with increased odds of PPCM development; hence, a low threshold for PPCM screening in this high-risk group is required.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CCR-EPUB-146637
doi: 10.2174/011573403X329136250116050817
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Huang W
      type: Person
      first name: Wilbert
      last name: Huang
      member of: Medical School, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 2
    item: Syahruddin SS
      type: Person
      first name: Siti Shofia
      last name: Syahruddin
      member of: Medical School, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 3
    item: Johansyah AA
      type: Person
      first name: Alexandra Aurelia
      last name: Johansyah
      member of: Medical School, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 4
    item: Suriadiredja SS
      type: Person
      first name: Siti Saqinah
      last name: Suriadiredja
      member of: Medical School, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 5
    item: Santoso DPJ
      type: Person
      first name: Dhanny Primantara Johari
      last name: Santoso
      member of: Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 6
    item: Sasotya RMS
      type: Person
      first name: R M Sonny
      last name: Sasotya
      member of: Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 7
    item: Azis MA
      type: Person
      first name: Muhammad Alamsyah
      last name: Azis
      member of: Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 8
    item: Pribadi A
      type: Person
      first name: Adhi
      last name: Pribadi
      member of: Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  slot:
    index: 9
    item: Prameswari HS
      type: Person
      first name: Hawani Sasmaya
      last name: Prameswari
      member of: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6557
has issn l: 1573-403X
has NLM journal title abbreviation: Curr Cardiol Rev
publication name: Current cardiology reviews
language: eng
has national library of medicine journal id: 101261935
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Cardiol Rev. 2025-02-13;():.

Clinimetric properties of clinical objective measurement methods for screening, diagnosis, and/or evaluation of lower limb lymphoedema: a systematic review with narrative synthesis of results.
pmid: 39949107
abstract: To offer a summary of the clinimetrics of measurement methods used for screening, diagnosis, and evaluation of lower limb lymphoedema (LLL).Data sources: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, a systematic literature search was conducted in PubMed, Web of Science, and EMBASE. Searches were performed on 1 December 2022 and reconducted on 18 July 2024. Study selection: Studies in patients with (or at risk for) LLL, whether or not compared to healthy controls. Data extraction: Quantitative data on clinimetric properties.Twenty-three papers were included and divided in papers reporting on clinimetrics of methods assessing swelling, skin properties, local tissue water, and intra- and extracellular fluid. Water displacement, opto-electronic volumetry, and circumference measures seem to be reliable measurement methods to be applied in clinical practice. Circumference measures (with 8 cm interval) is a time-efficient method with few practical limitations.Based on the little literature available in patients with LLL, we recommend to select different methods assessing more than one lymphedoema characteristic to get a clear overview on the patient's lymphoedema status. At this moment, literature is still unclear on the use of specific measurement methods in LLL. More research regarding validity, responsiveness, and feasibility is needed.
doi: 10.1080/09638288.2025.2459891
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: De Vrieze T
      type: Person
      first name: Tessa
      last name: De Vrieze
      member of: Research Group Rehabilitation in Internal Disorders (GRID), Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.MOVANT, Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.
  slot:
    index: 2
    item: Devoogdt N
      type: Person
      first name: Nele
      last name: Devoogdt
      member of: Research Group Rehabilitation in Internal Disorders (GRID), Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.Centre for Lymphedema, Department of Physical Medicine and Rehabilitation, and Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 3
    item: Gursen C
      type: Person
      first name: Ceren
      last name: Gursen
      member of: Research Group Rehabilitation in Internal Disorders (GRID), Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
  slot:
    index: 4
    item: Heroes AK
      type: Person
      first name: An-Kathleen
      last name: Heroes
      member of: Research Group Rehabilitation in Internal Disorders (GRID), Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.Centre for Lymphedema, Department of Physical Medicine and Rehabilitation, and Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 5
    item: Van Calster C
      type: Person
      first name: Charlotte
      last name: Van Calster
      member of: Research Group Rehabilitation in Internal Disorders (GRID), Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.Centre for Lymphedema, Department of Physical Medicine and Rehabilitation, and Department of Vascular Surgery, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 6
    item: Gebruers N
      type: Person
      first name: Nick
      last name: Gebruers
      member of: MOVANT, Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.
  slot:
    index: 7
    item: Moonen S
      type: Person
      first name: Sarah
      last name: Moonen
      member of: MOVANT, Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.
  slot:
    index: 8
    item: Hendrickx A
      type: Person
      first name: Ad
      last name: Hendrickx
      member of: Member European Reference Network ERN (VASCERN PPL), Dutch Center of Expertise for Lymphovascular Medicine, Nij Smellinghe Hospital, Drachten, The Netherlands.
  slot:
    index: 9
    item: Hidding J
      type: Person
      first name: Janine
      last name: Hidding
      member of: Department of Physical Therapy, Avans+, University of Applied Sciences, Breda, The Netherlands.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1464-5165
has issn l: 0963-8288
has NLM journal title abbreviation: Disabil Rehabil
publication name: Disability and rehabilitation
language: eng
has national library of medicine journal id: 9207179
rights holder: Lower limb lymphoedema (LLL) is a chronic condition for which an accurate diagnosis made with clinically available reliable, valid, and responsive measurement methods is needed.To date (and compared to upper limb lymphoedema), literature regarding clinimetric properties of measurement methods for LLL is scarce.To assess swelling of the lower limb, water displacement, opto-electronic volumetry, and circumference measures seem to be reliable measurement methods to be applied in clinical practice.Based on the limited literature, we recommend to select different measurement methods assessing more than one lymphoedema characteristic in order to get a clear overview on the patient’s lymphoedema status and to evaluate treatment effects.
derived from: NLM
starting page: 1
ending page: 16
has place of publication: England
source: Disabil Rehabil. 2025-02-13;():1-16.

The Link between Arterial Atherosclerotic and Venous Thromboembolic Disease.
pmid: 39949103
abstract: Traditionally, arterial atherosclerotic (AA) and venous thromboembolic (VTE) diseases have been separated into two independent entities. However, a body of evidence suggests the link between arterial and venous disease. In this narrative review, the relationship between these two vascular diseases is discussed. Different risk factors are common in both diseases, such as dyslipidaemia, metabolic syndrome, and thrombophilia. Etiopathogenetic mechanisms of both diseases are similar. Inflammation, as a basic pathogenetic mechanism of atherosclerotic disease, is also involved in the pathogenesis of VTE. Inflammation as a response to vessel wall injury promotes coagulation and inhibits endogenic fibrinolytic activity, which results in thromboembolic events in the arterial as well as in the venous system. A relationship has also been observed between preclinical or clinical atherosclerotic disease and VTE. These findings indicate that atherosclerosis may induce VTE or that common risk factors simultaneously stimulate the development of both diseases. The relationship between arterial and venous disease is also supported by the efficacy of some drugs (antiplatelets, anticoagulants, statins) in the prevention of both diseases. In conclusion, arterial and venous diseases share similar pathophysiological mechanisms, often driven by common risk factors. This overlap suggests that a unified approach to prevention and treatment may be beneficial for both conditions, potentially improving patient outcomes by addressing the underlying shared pathways.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CVP-EPUB-146669
doi: 10.2174/0115701611345232250212042958
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Poredos P
      type: Person
      first name: Pavel
      last name: Poredos
      member of: Department of Vascular Disease, University Medical Center Ljubljana, Slovenia.The University of Ljubljana Medical Faculty, Department of Internal Medicine, Slovenia.
  slot:
    index: 2
    item: Poredos P
      type: Person
      first name: Peter
      last name: Poredos
      member of: The University of Ljubljana Medical Faculty, Department of Internal Medicine, Slovenia.Department of Anaesthesiology and Surgical Intensive Care, University Medical Centre Ljubljana, Slovenia.
  slot:
    index: 3
    item: Jezovnik MK
      type: Person
      first name: Mateja K
      last name: Jezovnik
      member of: Department of Advanced Cardiopulmonary Therapies and Transplantation, The University of Texas Health Science Centre at Houston, Houston, TX, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1875-6212
has issn l: 1570-1611
has NLM journal title abbreviation: Curr Vasc Pharmacol
publication name: Current vascular pharmacology
language: eng
has national library of medicine journal id: 101157208
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Vasc Pharmacol. 2025-02-13;():.

Does PCR-based pathogen identification reduce mortality in bloodstream infections? Insights from a difference-in-difference analysis.
pmid: 39949119
abstract: Bloodstream infections (BSI) are associated with high mortality rates, particularly when caused by resistant pathogens. Reducing the delay in diagnosis and initiation of appropriate treatment is crucial for improving clinical outcomes. The implementation of polymerase chain reaction (PCR) tests in the diagnostic process offers a promising approach to achieving quicker identification of pathogens, thereby potentially reducing mortality associated with BSI.A difference-in-differences analysis was performed within a New York City hospital system, comparing mortality risk between patients with enterococcal BSI before and after the adoption of BCID2 PCR testing, using as control those with methicillin-sensitive S. aureus BSI, for which diagnostic protocol has been unchanged.The study included 548 inpatients; 164 diagnosed with vancomycin-resistant enterococci (VRE) BSI and 384 with MSSA BSI. The mean 30-day mortality risk difference in the period post-intervention estimated in our difference-in-differences model was -6.03 per 100 (95% CI: -10.35 to -1.7), with event study plots suggesting minimal deviation from parallel trends in the pre-treatment period.Findings suggest that introduction of BCID2 PCR testing for enterococcal bloodstream infections (BSI) may be associated with a reduction in mortality, however, interpretation of the effects must be approached with caution given the relative imprecision of estimates. Further research with larger samples is essential to establish a definitive conclusion on the impact of rapid PCR testing on mortality in BSI. This is an innovative approach using causal methods to evaluate interventions aimed at the improvement of infection control and antimicrobial treatment strategies.
has PII: S0899823X25000157
doi: 10.1017/ice.2025.15
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Gago J
      type: Person
      first name: Juan
      last name: Gago
      member of: Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, New York, USA.
  slot:
    index: 2
    item: Renson A
      type: Person
      first name: Audrey
      last name: Renson
      member of: Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, New York, USA.
  slot:
    index: 3
    item: Takats C
      type: Person
      first name: Courtney
      last name: Takats
      member of: Antimicrobial-Resistant Pathogens Program, New York University Grossman School of Medicine, New York10016, NY, USA.
  slot:
    index: 4
    item: Torres VJ
      type: Person
      first name: Victor J
      last name: Torres
      member of: Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, USA.Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, USA.
  slot:
    index: 5
    item: Shopsin B
      type: Person
      first name: Bo
      last name: Shopsin
      member of: Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, USA.Department of Microbiology, New York University Grossman School of Medicine, New York, USA.Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, USA.
  slot:
    index: 6
    item: Thorpe LE
      type: Person
      first name: Lorna E
      last name: Thorpe
      member of: Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, New York, USA.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:13
e ISSN: 1559-6834
has issn l: 0899-823X
has NLM journal title abbreviation: Infect Control Hosp Epidemiol
publication name: Infection control and hospital epidemiology
language: eng
has national library of medicine journal id: 8804099
derived from: NLM
starting page: 1
ending page: 7
has place of publication: United States
source: Infect Control Hosp Epidemiol. 2025-02-14;():1-7.

A Double-blind Randomized Split-mouth Clinical Trial on a Hemostatic Dental Material Containing Aloe Vera Nanoparticles: The Effects on Pain and Occurrence of Dry Socket after Tooth Extraction.
pmid: 39949105
abstract: Pain, infection, and dry socket are the primary complications following tooth extraction. Hence, the aim of this study was to evaluate the pain range and incidence of dry socket after using a hemostatic spongy material containing aloe vera nanoparticles after split-mouth extraction of the mandibular first and second molars, compared to a control sponge without aloe vera nanoparticles in patients referred to the Tabriz Faculty of Dentistry.This double-blind, split-mouth clinical study was conducted on 30 patients referred to the Faculty of Dentistry in Tabriz. Patients were selected according to specific inclusion and exclusion criteria and required extraction of two teeth. After tooth extraction, an aloe vera nanoparticle-containing hemostatic sponge was randomly placed in one extraction site, while a sponge without aloe vera nanoparticles served as the control in the other extraction site. Pain levels were measured at 12, 24, 48, and 72 h after extraction using a Visual Analog Scale (VAS), where patients marked their pain level from 1 (lowest pain) to 10 (highest pain) at each time point. Patients received a form to record the required information and instructions on how to do so, which they submitted upon completion. To assess the occurrence of dry socket, patients were asked to come four days after extraction. Data were analyzed using SPSS software with relevant statistical tests, considering a significance level of P<0.05.In both groups, the average pain levels decreased significantly over 72 h (P=0.001 and P=0.01 for the test and control groups, respectively). Additionally, for 48 h and 72 h time points, the test group showed better pain control results than the control group (P=0.04 and P=0.04 for 48 h and 72 h, respectively). No cases of dry sockets were found in either group.The aloe vera-containing sponge demonstrated better performance in pain control following tooth extraction compared to the control group. For dry socket occurrence, both sponges showed s[cell cut: 2015 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146665
doi: 10.2174/0113892010363882250210054655
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Vazirabadi SB
      type: Person
      first name: Samin Baghban
      last name: Vazirabadi
      member of: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 2
    item: Mehrpouya M
      type: Person
      first name: Mahsa
      last name: Mehrpouya
      member of: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 3
    item: Motallebi N
      type: Person
      first name: Naiemeh
      last name: Motallebi
      member of: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 4
    item: Hosseini O
      type: Person
      first name: Olduz
      last name: Hosseini
      member of: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 5
    item: Khosroshahi AZ
      type: Person
      first name: Ali Zaheri
      last name: Khosroshahi
      member of: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 6
    item: Sharifi S
      type: Person
      first name: Simin
      last name: Sharifi
      member of: Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 7
    item: Dizaj SM
      type: Person
      first name: Solmaz Maleki
      last name: Dizaj
      member of: Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 8
    item: Ghavimi MA
      type: Person
      first name: Mohammad Ali
      last name: Ghavimi
      member of: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:03
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-13;():.

Among common neuropsychological tests, the Paced auditory serial addition test is the strongest predictor of trait fatigue in patients with traumatic brain injury.
pmid: 39949125
abstract: Fatigue is one of the most common symptoms following traumatic brain injury (TBI). Despite its prevalence, fatigue remains a challenging concept to define and measure. The aim of the present study was to explore potential relationships between self-rated fatigue in patients with TBI and performance on several widely used neuropsychological tests. In a cross-sectional design, patients with TBI (n = 68) and healthy controls (n = 27) underwent a comprehensive battery of commonly used neuropsychological tests and completed two self-assessment fatigue scales, the Fatigue Severity Scale and the Mental Fatigue Scale. Patients with TBI performed worse on neuropsychological tests of short-term memory, processing speed and executive functioning (inhibition) compared to healthy controls. Within the TBI group, only the Paced Auditory Serial Addition Test (PASAT) and the Stroop-Inhibition task showed significant correlations with measures of fatigue. However, after adjusting for relevant demographic variables, including age, gender, education and TBI severity, only PASAT remained significantly associated with the Mental Fatigue Scale (r = .45, p = .005). Within the healthy control group, no such associations were found. These results highlight an interesting relationship between PASAT performance and self-assessed fatigue. With further research, PASAT, modifications of it or similar measures could potentially help clinicians in evaluating fatigue in patients with TBI.
rights: © 2025 The Author(s). Journal of Neuropsychology published by John Wiley & Sons Ltd on behalf of The British Psychological Society.
doi: 10.1111/jnp.12419
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Berginström N
      type: Person
      first name: Nils
      last name: Berginström
      member of: Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden.Department of Psychology, Umeå University, Umeå, Sweden.
  slot:
    index: 2
    item: Thelander J
      type: Person
      first name: Johan
      last name: Thelander
      member of: Sundsvall-Härnösand County Hospital, Sundsvall, Sweden.
  slot:
    index: 3
    item: Nordström P
      type: Person
      first name: Peter
      last name: Nordström
      member of: Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
  slot:
    index: 4
    item: Nordström A
      type: Person
      first name: Anna
      last name: Nordström
      member of: School of Sport Sciences, UiT the Arctic University of Norway, Tromsø, Norway.Department of Medical Sciences, Health Sciences, Uppsala University, Uppsala, Sweden.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:13
e ISSN: 1748-6653
has issn l: 1748-6645
has NLM journal title abbreviation: J Neuropsychol
publication name: Journal of neuropsychology
language: eng
has national library of medicine journal id: 101468753
derived from: NLM
has place of publication: England
source: J Neuropsychol. 2025-02-13;():.

Comparison of oncological outcomes of T1-3 N1 rectal cancer patients treated with neoadjuvant radiotherapy versus no radiotherapy: A retrospective cohort study.
pmid: 39949126
abstract: Neoadjuvant short-course radiotherapy (SCRT) prior to surgery has been used to reduce local recurrences in moderately advanced rectal cancer (RC). Total mesorectal excision (TME) surgery by itself can reduce the local recurrence rate in these patients. The objective was to assess whether discontinuing neoadjuvant SCRT had a negative impact on survival and local recurrence rates of moderately advanced RC.This retrospective study examined 137 consecutive patients (67 neoadjuvant SCRT, 70 TME without neoadjuvant therapy) treated for rT1-3N1M0 RC without extramural venous invasion (EMVI) or a threatened surgical margin between January 2016 and March 2020 in a tertiary rectal surgery referral center. The primary objective was the impact of neoadjuvant therapy on overall, cancer-specific, and disease-free survival, and local recurrence rate. Secondary outcomes were risk factors affecting survival. The analyses were conducted on the total study cohort as well as a propensity score matched cohort of the same patient group, with the matching predicated upon age, gender, and histological T score.The oncological outcomes were similar between the two different treatment groups. The 5-year cumulative overall survival rate, calculated using the Kaplan-Meier method, was 89.6% in the neoadjuvant SCRT group and 83.5% in the surgery-only group (p = 0.570), with the corresponding cancer-specific survival rates at 97.0% and 98.4% (p = 0.219) and disease-free survival rates at 97.0% and 91.9% (p = 0.438). No local recurrencies were detected in either group during the 5-year follow-up period.The omission of neoadjuvant SCRT in rT1-3N1M0 RC with no EMVI and no threatened resection margin caused no adverse effects on the survival of the patients. Based on this series, it appears that avoiding SCRT does not compromise the oncological outcome in these patients.
doi: 10.1177/14574969251319201
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Marjasuo S
      type: Person
      first name: Suvi
      last name: Marjasuo
      member of: Department of Radiology, Helsinki University Hospital, Helsinki Finland University of Helsinki Helsinki Finland.
  slot:
    index: 2
    item: Koskenvuo L
      type: Person
      first name: Laura
      last name: Koskenvuo
      member of: Gastroenterological Surgery, Helsinki University Hospital, Helsinki, Finland.University of Helsinki, Helsinki, Finland.
  slot:
    index: 3
    item: Lepistö A
      type: Person
      first name: Anna
      last name: Lepistö
      member of: Department of Surgery, Helsinki University Hospital, Helsinki, Finland.University of Helsinki, Helsinki, Finland.Applied Tumor Genomics, Research Projects Unit Organization, University of Helsinki, Helsinki, Finland.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:13
e ISSN: 1799-7267
has issn l: 1457-4969
has NLM journal title abbreviation: Scand J Surg
publication name: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society
language: eng
has national library of medicine journal id: 101144297
derived from: NLM
pg: 14574969251319201
has place of publication: England
source: Scand J Surg. 2025-02-13;():14574969251319201.

http://rdf.ncbi.nlm.nih.gov/pubmed/39949124
pmid: 39949124
has PII: 8013527
doi: 10.1093/cid/ciaf066
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Munsiff SS
      type: Person
      first name: Sonal S
      last name: Munsiff
      member of: Associate Professor, Division of Infectious Diseases, University of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 689 Rochester NY 14642, United States.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:13
e ISSN: 1537-6591
has issn l: 1058-4838
has NLM journal title abbreviation: Clin Infect Dis
publication name: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
language: eng
has national library of medicine journal id: 9203213
derived from: NLM
has place of publication: United States
source: Clin Infect Dis. 2025-02-14;():.
title: American Thoracic Society/Centers for Disease Control and Prevention/European Respiratory Society/Infectious Diseases Society of America (ATS/CDC/ERS/IDSA) Updated guideline on the treatment of tuberculosis.

Chatting new territory: large language models for infection surveillance from pilot to deployment.
pmid: 39949129
abstract: Rodriguez-Nava et al. present a proof-of-concept study evaluating the use of a secure large language model (LLM) approved for healthcare data for retrospective identification of a specific healthcare-associated infection (HAI)-central line-associated bloodstream infections-from real patient data for the purposes of surveillance.1 This study illustrates a promising direction for how LLMs can, at a minimum, semi-automate or streamline HAI surveillance activities.
has PII: S0899823X25000200
doi: 10.1017/ice.2025.20
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Wu JT
      type: Person
      first name: Julie T
      last name: Wu
      member of: Department of Medicine, VA Palo Alto Healthcare System, Palo Alto, CA, USA.Department of Medicine, Division of Oncology, Stanford University School of Medicine, Palo Alto, CA, USA.
  slot:
    index: 2
    item: Langford BJ
      type: Person
      first name: Bradley J
      last name: Langford
      member of: Dalla Lana School of Public Health, University of Toronto, Canada.
  slot:
    index: 3
    item: Shenoy ES
      type: Person
      first name: Erica S
      last name: Shenoy
      member of: Infection Control, Mass General Brigham, Boston, MA, USA.Division of Infections Diseases, Massachusetts General Hospital, Boston, MA, US.Harvard Medical School, Boston, MA, USA.
  slot:
    index: 4
    item: Carey E
      type: Person
      first name: Evan
      last name: Carey
      member of: Digital Health Office, Veterans Health Administration, National Artificial Intelligence Institute, Washington, DC, USA.Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  slot:
    index: 5
    item: Branch-Elliman W
      type: Person
      first name: Westyn
      last name: Branch-Elliman
      member of: Department of Medicine, Section of Infectious Diseases, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.Digital Health Office, National Artificial Intelligence Institute, Washington, DC, USA.Department of Medicine, Section of Infectious Diseases, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:13
e ISSN: 1559-6834
has issn l: 0899-823X
has NLM journal title abbreviation: Infect Control Hosp Epidemiol
publication name: Infection control and hospital epidemiology
language: eng
has national library of medicine journal id: 8804099
derived from: NLM
starting page: 1
ending page: 3
has place of publication: United States
source: Infect Control Hosp Epidemiol. 2025-02-14;():1-3.

Risk factors of blood transfusion following primary total hip replacement.
pmid: 39949134
abstract: Total hip replacement is a quality of life-enhancing procedure. Postoperative blood transfusion is a risk factor compromising the outcome of total hip replacement and increasing the risk of deep infection. The aim of this study is to determine the risk factors for postoperative blood transfusion after total hip replacement.In this retrospective study, 3901 patients underwent primary total hip replacement, in the period between January 2015 and December 2023. The mean age of the participants was 67.3 (SD: 12.6) years, and 61% of them were females. Participants were divided into 'transfusion' and 'non-transfusion' groups.Forty-two patients (1.1%) received blood transfusion after total hip replacement. In a multivariable logistic regression analysis, preoperative haemoglobin was the only independent risk factor that reduced the odds of postoperative transfusion by 0.3 (95% confidence interval: 0.23-0.39) for every 1 g/dL increase.Postoperative blood transfusion is a rare, yet potentially serious, occurrence after total hip replacement. In this study, preoperative haemoglobin level was the only independent risk factor associated with postoperative transfusion. We recommend aiming to achieve minimum preoperative haemoglobin level of 13 g/dL to minimise the risk of postoperative transfusion.
doi: 10.1177/17504589251317325
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Askar M
      type: Person
      first name: Mohamed
      last name: Askar
      member of: Cardiff and Vale University Health Board, Cardiff, UK.Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  slot:
    index: 2
    item: Zedan Y
      type: Person
      first name: Yasmine
      last name: Zedan
      member of: Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  slot:
    index: 3
    item: Davies O
      type: Person
      first name: Owain
      last name: Davies
      member of: Cardiff and Vale University Health Board, Cardiff, UK.
  slot:
    index: 4
    item: John A
      type: Person
      first name: Alun
      last name: John
      member of: Cardiff and Vale University Health Board, Cardiff, UK.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:22
e ISSN: 2515-7949
has issn l: 1750-4589
has NLM journal title abbreviation: J Perioper Pract
publication name: Journal of perioperative practice
language: eng
has national library of medicine journal id: 101271023
derived from: NLM
pg: 17504589251317325
has place of publication: England
source: J Perioper Pract. 2025-02-13;():17504589251317325.

The first series of implantations of the Harmony valve in Europe: the beginning of a new era for percutaneous pulmonary valve implantation also in the Old Continent?
pmid: 39949132
abstract: For many patients with right ventricular outflow tract (RVOT) dysfunction, percutaneous pulmonary valve implantation (PPVI) offers a less-invasive alternative treatment option to surgery with a similar long-term result. However, the implantation of the valves recently available on the European market was only possible in patients with a limited maximal RVOT diameter. In patients with large RVOT, surgical treatment has remained the only possible treatment modality until recently. The self-expandable Harmony transcatheter pulmonary valve is a valve dedicated for patients with severe pulmonary regurgitation in the native and surgically repaired wide RVOT. The initial experience worldwide with this valve is very promising. However, it has not been implanted in Europe until recently. We report on four young adult patients with severe pulmonary valve regurgitation who underwent a successful PPVI with Harmony valve implantation. There were no serious complications in our small study group. In conclusion, the Harmony valve may offer a less-invasive and safe treatment alternative to surgery for patients in whom the available balloon-expandable valves offer only limited applicability. This valve has only recently become accessible on the European market.
has PII: S1047951125000605
doi: 10.1017/S1047951125000605
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Gendera K
      type: Person
      first name: K
      last name: Gendera
      member of: Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, Technische Universität München, Munich, Germany.
  slot:
    index: 2
    item: Cheatham J
      type: Person
      first name: J
      last name: Cheatham
      member of: Department of Cardiology, The Ohio State University, Columbus, OH, USA.
  slot:
    index: 3
    item: Georgiev S
      type: Person
      first name: S
      last name: Georgiev
      member of: Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, Technische Universität München, Munich, Germany.
  slot:
    index: 4
    item: Ewert P
      type: Person
      first name: P
      last name: Ewert
      member of: Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, Technische Universität München, Munich, Germany.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:22
e ISSN: 1467-1107
has issn l: 1047-9511
has NLM journal title abbreviation: Cardiol Young
publication name: Cardiology in the young
language: eng
has national library of medicine journal id: 9200019
derived from: NLM
starting page: 1
ending page: 4
has place of publication: England
source: Cardiol Young. 2025-02-14;():1-4.

Do the current continuous professional development approaches for registered nurses and operating department practitioners within perioperative care meet their learning needs?
pmid: 39949135
abstract: In the highly specialised and rapidly evolving field of perioperative care, continuous professional development is essential for maintaining the competencies of healthcare professionals, directly impacting patient safety and the quality of care. This project aimed to assess the effectiveness of current continuous professional development approaches in meeting the learning needs of registered nurses and operating department practitioners within perioperative care in a United Kingdom National Health Service Trust hospital. A comprehensive self-assessment strategy was intended to evaluate the condition of current continuous professional development approaches, identify areas for improvement, and explore innovative uptake for improvement. Using a mixed-methods design, data were collected via an online survey of 76 participants. The data demonstrated significant knowledge, skill, and competency deficiencies, revealing that many current continuous professional development approaches lacked accessibility and relevance. This study may provide valuable insights for refining continuous professional development programmes to meet evolving learning needs better and improve patient outcomes.
doi: 10.1177/17504589251316391
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Ssemakula TN
      type: Person
      first name: Teopista Namubiru
      last name: Ssemakula
      member of: Barts Health NHS Trust, London, UK.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:22
e ISSN: 2515-7949
has issn l: 1750-4589
has NLM journal title abbreviation: J Perioper Pract
publication name: Journal of perioperative practice
language: eng
has national library of medicine journal id: 101271023
derived from: NLM
pg: 17504589251316391
has place of publication: England
source: J Perioper Pract. 2025-02-13;():17504589251316391.

Simultaneous transcatheter closure of atrial septal defect, ventricular septal defect, and patent ductus arteriosus.
pmid: 39949141
abstract: We report simultaneous transcatheter closure of a secundum atrial septal defect, a perimembranous ventricular septal defect, and a patent ductus arteriosus in a 3-year-old female wıth symptoms of heart failure. As it was not possible to determine the impact of each defect on the patient's symptoms, all of them were closed with good results, for a tiny residual venrricular septal defect.
has PII: S1047951124036643
doi: 10.1017/S1047951124036643
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Emral HG
      type: Person
      first name: Hicran Gül
      last name: Emral
      member of: Royal Brompton and Harefield Hospitals, pediatric cardiology, London, UK.
  slot:
    index: 2
    item: Gupta P
      type: Person
      first name: Palak
      last name: Gupta
      member of: Royal Brompton & Harefield NHS Foundation Trust, pediatric cardiology, London, UK.
  slot:
    index: 3
    item: Fraisse A
      type: Person
      first name: Alain
      last name: Fraisse
      member of: Royal Brompton and Harefield Hospitals, pediatric cardiology, London, UK.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:23
e ISSN: 1467-1107
has issn l: 1047-9511
has NLM journal title abbreviation: Cardiol Young
publication name: Cardiology in the young
language: eng
has national library of medicine journal id: 9200019
derived from: NLM
starting page: 1
ending page: 3
has place of publication: England
source: Cardiol Young. 2025-02-14;():1-3.

In search of a habitable world: The long journey of women who survived breast cancer.
pmid: 39949143
abstract: The aim of the study was to better understand the experiences of women living with a history of breast cancer by analyzing the metaphors they use to describe their experiences. Data were collected through individual narrative interviews with 10 women, who were between 4 years and 13 years post-diagnosis. Their narratives were analyzed using Interpretative Phenomenological Analysis. The results are presented from an existential perspective and are conceptualized using the metaphor of the home. Our interpretation suggests that participants were in search of a habitable world, seeking to (1) dwell in oneself, (2) dwell with others and (3) dwell in the world. The results were discussed using an intersubjective conceptual framework, enriched by the work of Stolorow on human suffering and emotional trauma. The study expands upon existing literature on the use of metaphors in cancer patients and contributes to reveal their richness and diversity, beyond the dominant war metaphor.
doi: 10.1177/13634593251319919
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Guité-Verret A
      type: Person
      first name: Alexandra
      last name: Guité-Verret
      member of: Université du Québec à Montréal, Canada.
  slot:
    index: 2
    item: Vachon M
      type: Person
      first name: Melanie
      last name: Vachon
      member of: Université du Québec à Montréal, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:23
e ISSN: 1461-7196
has issn l: 1363-4593
has NLM journal title abbreviation: Health (London)
publication name: Health (London, England : 1997)
language: eng
has national library of medicine journal id: 9800465
derived from: NLM
pg: 13634593251319919
has place of publication: England
source: Health (London). 2025-02-13;():13634593251319919.

Perioperative prediction of adverse events with age-adjusted NT-proBNP in children undergoing Norwood surgery.
pmid: 39949144
abstract: Due to the high postoperative mortality, tools for an adaequate risk stratification are important to identify high-risk patients undergoing the Norwood procedure. As a marker of ventricular wall stress, NT-proBNP might be of particular interest in these children.This study evaluated whether NT-proBNP's age-adjusted z-score ( zlog-NT-proBNP ) predicts outcomes after stage I Norwood procedure.Patients who underwent the Norwood procedure between 1 January 2011 and 31 December 2022, with perioperative NT-proBNP measurements available were enrolled. Since reference intervals of NT-proBNP are highly age-dependent, age-adjusted zlog-NT-proBNP was used. Serial zlog-NT-proBNP values were analysed to predict the occurrence of major adverse cardiovascular events after the Norwood procedure. Major adverse cardiovascular events was defined as death, resuscitation, or mechanical circulatory support. Secondary endpoints were re-operation and re-intervention for shunt.A total of 139 patients underwent the Norwood procedure and had at least one NT-proBNP measurement available. Preoperative zlog-NT-proBNP measurements (median 3.7, interquartile range 3.1-4.19) showed no association with the occurrence of major adverse cardiovascular events or mortality. Zlog-NT-proBNP early after ICU admission (3.2, interquartile range 2.4-3.8) was predictive of mortality but showed no association with the occurrence of major adverse cardiovascular events. Zlog-NT-proBNP before ICU discharge (3.2, interquartile range 2.8-3.8) was significantly associated with the occurrence of both major adverse cardiovascular events (hazard ratio 1.83, 95% confidence interval 1.25-2.67, P = 0.002) and death (hazard ratio 2.1, 95% CI 1.4-3.2, P < 0.001).High zlog-NT-proBNP levels after the Norwood surgery were strongly associated with the occurrence of major adverse cardiovascular events and death. Therefore, zlog-NT-proBNP has the potential to identify high-risk patients before life-threatening complications occur.
has PII: S1047951125000290
doi: 10.1017/S1047951125000290
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Niedermaier C
      type: Person
      first name: Carolin
      last name: Niedermaier
      member of: Technical University of Munich, German Heart Center, Department for Congenital and Pediatric Heart Surgery, Division for Congenital and Pediatric Heart Surgery, University Hospital Großhadern, Ludwig-Maximilians University, Munich, Germany.
  slot:
    index: 2
    item: Ono M
      type: Person
      first name: Masamichi
      last name: Ono
      member of: Technical University of Munich, German Heart Center, Department for Congenital and Pediatric Heart Surgery, Division for Congenital and Pediatric Heart Surgery, University Hospital Großhadern, Ludwig-Maximilians University, Munich, Germany.
  slot:
    index: 3
    item: Klawonn F
      type: Person
      first name: Frank
      last name: Klawonn
      member of: Biostatistics, Helmholtz Center for Infection Research, Braunschweig, Germany.Institute for Information Engineering, Ostfalia University of Applied Sciences, Wolfenbuttel, Germany.
  slot:
    index: 4
    item: Holdenrieder S
      type: Person
      first name: Stefan
      last name: Holdenrieder
      member of: Institute of Laboratory Medicine, German Heart Center of the Technical University Munich, Munich, Germany.
  slot:
    index: 5
    item: Lemmer J
      type: Person
      first name: Julia
      last name: Lemmer
      member of: Technical University of Munich, German Heart Center, Department of Pediatric Cardiology and Congenital Heart Defects, Munich, Germany.
  slot:
    index: 6
    item: Hörer J
      type: Person
      first name: Jürgen
      last name: Hörer
      member of: Technical University of Munich, German Heart Center, Department for Congenital and Pediatric Heart Surgery, Division for Congenital and Pediatric Heart Surgery, University Hospital Großhadern, Ludwig-Maximilians University, Munich, Germany.
  slot:
    index: 7
    item: Ewert P
      type: Person
      first name: Peter
      last name: Ewert
      member of: Technical University of Munich, German Heart Center, Department of Pediatric Cardiology and Congenital Heart Defects, Munich, Germany.DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
  slot:
    index: 8
    item: Palm J
      type: Person
      first name: Jonas
      last name: Palm
      member of: Technical University of Munich, German Heart Center, Department of Pediatric Cardiology and Congenital Heart Defects, Munich, Germany.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:23
e ISSN: 1467-1107
has issn l: 1047-9511
has NLM journal title abbreviation: Cardiol Young
publication name: Cardiology in the young
language: eng
has national library of medicine journal id: 9200019
derived from: NLM
starting page: 1
ending page: 10
has place of publication: England
source: Cardiol Young. 2025-02-14;():1-10.

Alterations in the intestinal microbiome and immune dysregulation in infants with CHD undergoing cardiopulmonary bypass: a scoping review.
pmid: 39949145
abstract: Infants who require cardiopulmonary bypass for surgical repair of CHD are at high risk for secondary infections, which cause significant death and disability. The risk of secondary infection is increased by immune dysfunction. The intestinal microbiome calibrates immune function. Infants with CHD have substantial changes in their intestinal microbiome. We performed this scoping review to describe the current understanding of the relationship between the intestinal microbiome and immune function after pediatric cardiac surgery with cardiopulmonary bypass.We searched the PubMed, Cumulative Index to Nursing and Allied Health Literature, Cochrane, and Scopus databases with the assistance of a medical librarian. We included trials that analysed intestinal microbiome composition and immune function after cardiac surgery with cardiopulmonary bypass in infants.We found two observational cohorts and two interventional trials describing composition of intestinal microbiome and some measures of immune function after heart surgery with cardiopulmonary bypass in infants. A total of 114 children were analysed. Three trials were exclusively in infants, and one was in older children and infants. All trials found a differential composition of the intestinal microbiome in infants with CHD compared to those without CHD, and one described a robust correlation between composition of the intestinal microbiome with cytokine profile and adverse outcomes.Despite robust preclinical data and data from other disease states, there is minimal data about the correlation between immune function and intestinal microbiome composition in infants with CHD after cardiopulmonary bypass.
has PII: S1047951125000332
doi: 10.1017/S1047951125000332
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Prout AJ
      type: Person
      first name: Andrew J
      last name: Prout
      member of: Department of Pediatrics, Central Michigan University College of Medicine, Mt. Pleasant, MI, USA.Division of Pediatric Critical Care Medicine, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, USA.
  slot:
    index: 2
    item: Meert KL
      type: Person
      first name: Kathleen L
      last name: Meert
      member of: Department of Pediatrics, Central Michigan University College of Medicine, Mt. Pleasant, MI, USA.Division of Pediatric Critical Care Medicine, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, USA.
  slot:
    index: 3
    item: Al-Ahmadi M
      type: Person
      first name: Mamdouh
      last name: Al-Ahmadi
      member of: Division of Pediatric Cardiovascular Surgery, Department of Surgery, Children's Hospital of Michigan, Detroit, MI, USA.
  slot:
    index: 4
    item: Dickson RP
      type: Person
      first name: Robert P
      last name: Dickson
      member of: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.Weil Institute for Critical Care Research & Innovation, Ann Arbor, MI, USA.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:23
e ISSN: 1467-1107
has issn l: 1047-9511
has NLM journal title abbreviation: Cardiol Young
publication name: Cardiology in the young
language: eng
has national library of medicine journal id: 9200019
derived from: NLM
starting page: 1
ending page: 6
has place of publication: England
source: Cardiol Young. 2025-02-14;():1-6.

Implementing biowaste source segregation for sustainable decentralized composting schemes in Tiassalé, southern Côte d'Ivoire.
pmid: 39949152
abstract: Research in sub-Saharan Africa has shown failures in most of municipal waste composting initiatives because of bad-quality composts due to the lack of biowaste source segregation. Until now, very few biowaste source-segregation initiatives have been carried out on this part of the world. This study aimed at assessing the biowaste sorting efficiency and the attitude of households towards a pilot biowaste source-segregation system linked to a decentralized composting plant in Tiassalé. For this purpose, the impurity rate of source-segregated biowaste was monitored through the first year of implementation. Then, a cross-sectional survey was conducted to evaluate households' attitude. The results have shown that the average impurities rate in source-segregated biowaste was very low (1%). This finding was confirmed by the results of laboratory analysis which revealed a very low heavy metals (0.2, 12.4, 7.1 and 15.5 mg kg-1 DS for Cd, Cr, Ni and Pb, respectively) contamination in the compost produced. Regarding the acceptability of the source-segregation system, the results showed that the majority (75%) of the participants accepted the source-segregation system of biowaste and almost half (47%) of them were ready to pay for such a collection service. In conclusion, this study revealed that providing households with the needed municipal solid waste management infrastructures and rising awareness about biowaste source segregation are keys for the establishment of such a collection system in Tiassalé and similar urban areas. The findings also proved the effectiveness of biowaste source-segregation system in the production of high-quality compost.
doi: 10.1177/0734242X251313919
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Dongo K
      type: Person
      first name: Kouassi
      last name: Dongo
      member of: Unité de Formation et de Recherche des Sciences de la Terre et des Ressources Minières (UFR STRM), Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire.CSRS: Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
  slot:
    index: 2
    item: Yeo D
      type: Person
      first name: Dotanhan
      last name: Yeo
      member of: CSRS: Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.Unité de Formation et de Recherche Agriculture, Ressource halieutique et Agro-industrie (UFR ARHAI), Université de San Pedro, San-Pedro, Côte d'Ivoire.
  slot:
    index: 3
    item: Gnagne T
      type: Person
      first name: Théophile
      last name: Gnagne
      member of: Unité de Formation et de Recherche Sciences et Gestion de l'Environnement (UFR SGE), Université Nangui Abrogoua, Abidjan, Côte d'Ivoire.
  slot:
    index: 4
    item: Mertenat A
      type: Person
      first name: Adeline
      last name: Mertenat
      member of: Eawag : Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland.
  slot:
    index: 5
    item: Lüssenhop P
      type: Person
      first name: Phillipp
      last name: Lüssenhop
      member of: Institute of Wastewater Management and Water Protection, Bioresource Management Group, Hamburg University of Technology, Hamburg, Germany.
  slot:
    index: 6
    item: Zurbrügg C
      type: Person
      first name: Christian
      last name: Zurbrügg
      member of: Eawag : Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland.
  slot:
    index: 7
    item: Körner I
      type: Person
      first name: Ina
      last name: Körner
      member of: Institute of Wastewater Management and Water Protection, Bioresource Management Group, Hamburg University of Technology, Hamburg, Germany.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:33
e ISSN: 1096-3669
has NLM journal title abbreviation: Waste Manag Res
publication name: Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA
language: eng
has national library of medicine journal id: 9881064
derived from: NLM
pg: 734242X251313919
has place of publication: England
source: Waste Manag Res. 2025-02-13;():734242X251313919.

Potential for synergistic conservation through area-based strategies.
pmid: 39949146
abstract: The ongoing biodiversity crisis has raised concerns about the effectiveness of area-based conservation (ABC) strategies for achieving positive biodiversity outcomes. In riverine ecosystems, the linear habitat structure of fishes introduces uncertainty into the synergistic conservation potential of ABC. Therefore, to assess the synergistic conservation potential of ABC for multiple groups, we used data from IUCN and RivFishTIME database up to 2020 for fishes, mammals, and birds to assess the reliability of area sampling based on species-area relationships and latitudinal dependence analyses. We built a spatial model of species richness to determine the spatial distribution of species richness and the spatial overlap of species richness within and among the 3 groups under different group combinations. We found a significant power function relationship between area and species richness; R2 values ranged from 0.94 to 0.96. Species richness was unevenly distributed across groups; thus, the potential for synergistic conservation of multiple groups is not promising. Fish were outliers. The spatial overlap for fish-bird combinations (β = -0.001 to 0.02) and fish-mammal combinations (β = 0.10-0.11) were significantly lower than those for mammal-bird combinations (β = 0.20-0.27). This calls for targeted conservation planning for fishes in terrestrial ecosystems rather than considering that protected areas for mammals and birds will also protect fishes. Furthermore, the synergistic conservation potential of multitarget strategies cannot be safely extended to all groups.
rights: © 2025 The Author(s). Conservation Biology published by Wiley Periodicals LLC on behalf of Society for Conservation Biology.
doi: 10.1111/cobi.14447
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zhang L
      type: Person
      first name: Li
      last name: Zhang
      member of: State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  slot:
    index: 2
    item: Fu Y
      type: Person
      first name: Yanwen
      last name: Fu
      member of: State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.College of Life Sciences, Beijing Normal University, Beijing, China.
  slot:
    index: 3
    item: Li J
      type: Person
      first name: Jiaxin
      last name: Li
      member of: College of Fisheries and Life Science, Dalian Ocean University, Dalian, China.
  slot:
    index: 4
    item: Yan L
      type: Person
      first name: Lingyan
      last name: Yan
      member of: State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  slot:
    index: 5
    item: Kou X
      type: Person
      first name: Xiaojun
      last name: Kou
      member of: College of Life Sciences, Beijing Normal University, Beijing, China.
  slot:
    index: 6
    item: Ouyang Z
      type: Person
      first name: Zhiyun
      last name: Ouyang
      member of: State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:32
e ISSN: 1523-1739
has issn l: 0888-8892
has NLM journal title abbreviation: Conserv Biol
publication name: Conservation biology : the journal of the Society for Conservation Biology
language: eng
has national library of medicine journal id: 9882301
rights holder: Potencial para la conservación sinérgica por medio de estrategias basadas en el área Resumen La actual crisis de la biodiversidad genera inquietud sobre la eficacia de las estrategias de conservación basadas en el área (CBA) para lograr resultados positivos para la biodiversidad. En los ecosistemas fluviales, la estructura lineal del hábitat de los peces introduce incertidumbre en el potencial sinérgico de conservación de la CBA. Por lo tanto, para evaluar el potencial de conservación sinérgico de la CBA para múltiples grupos, utilizamos datos de la UICN y de la base de datos RivFishTIME hasta 2020 para peces, mamíferos y aves con el fin de evaluar la fiabilidad del muestreo de áreas basado en las relaciones especie‐área y los análisis de dependencia latitudinal. Construimos un modelo espacial de riqueza de especies para determinar la distribución espacial de la riqueza de especies y el traslape espacial de la riqueza de especies dentro de los tres grupos y entre ellos bajo diferentes combinaciones de grupos. Encontramos una relación significativa de función de potencia entre el área y la riqueza de especies; los valores de R2 oscilaron entre 0.94 y 0.96. La riqueza de especies se distribuyó desigualmente entre los tres grupos, por lo que el potencial de conservación sinérgica de múltiples grupos no es prometedor. Los peces fueron valores atípicos. El traslape espacial de las combinaciones pez‐ave (β = ‐0.001 a 0.02) y pez‐mamífero (β = 0.10‐0.11) fueron significativamente menores que el de las combinaciones mamífero‐ave (β = 0.20‐0.27). Esto exige una planificación de la conservación específica para los peces en los ecosistemas terrestres en lugar de considerar que las áreas protegidas para mamíferos y aves también protegerán a los peces. Además, el potencial sinérgico de conservación de las estrategias con múltiples objetivos no puede extenderse con seguridad a todos los grupos.
derived from: NLM
pg: e14447
has place of publication: United States
source: Conserv Biol. 2025-02-13;():e14447.

Language-specific approaches to reduce perioperative stress and anxiety related to anaesthesia for patients with limited English proficiency: A narrative review.
pmid: 39949150
abstract: Many patients experience perioperative anxiety due to a variety of different reasons. Essential processes of shared decision-making and informed consent may help to mitigate anxiety, yet language barriers may hinder this particularly in diverse patient populations. As such, language-specific approaches in anaesthesia care play a crucial role in reducing perioperative stress and anxiety among patients with limited English proficiency. This review examines which methods during anaesthetic assessments and shared decision-making processes enable anaesthetists to communicate effectively with patients who have limited English proficiency and thereby reduce perioperative stress. Findings suggest that collaborating with patients in their native language significantly reduces anxiety and improves understanding, while transcreation - culturally adapted translation - enhances the effectiveness of communication. To decrease perioperative anxiety among populations with limited English proficiency and improve surgical outcomes, it is important to enhance anaesthesia-focused training for interpreters, increase diversity in the anaesthesia field, and develop culturally relevant patient education materials.
doi: 10.1177/17504589251316744
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Dhaliwal KK
      type: Person
      first name: Kanwarpreet Kaur
      last name: Dhaliwal
      member of: Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
  slot:
    index: 2
    item: Sandhu S
      type: Person
      first name: Sherry
      last name: Sandhu
      member of: Fraser Health Authority, Surrey, British Columbia, Canada.
  slot:
    index: 3
    item: Puri N
      type: Person
      first name: Nitasha
      last name: Puri
      member of: Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.Fraser Health Authority, Surrey, British Columbia, Canada.
  slot:
    index: 4
    item: Toor A
      type: Person
      first name: Amolpreet
      last name: Toor
      member of: Department of Anesthesiology, Pharmacology, and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:33
e ISSN: 2515-7949
has issn l: 1750-4589
has NLM journal title abbreviation: J Perioper Pract
publication name: Journal of perioperative practice
language: eng
has national library of medicine journal id: 101271023
derived from: NLM
pg: 17504589251316744
has place of publication: England
source: J Perioper Pract. 2025-02-13;():17504589251316744.

[The experiences of aftercare by patients and their relatives after a critical illness in the intensive care unit: A meta-synthesis].
pmid: 39949157
abstract: The experiences of aftercare by patients and their relatives after a critical illness in the intensive care unit: A meta-synthesis Abstract: Background: Survival of critically ill patients has improved due to progress in intensive care treatment options. However, around 50% are affected by long-term consequences, which are summarized as Post Intensive Care Syndrome (PICS) and highlight the need for aftercare. Aim: How do patients and their relatives perceive life after a critical illness in an intensive care unit and aftercare? Methods: A meta-synthesis of qualitative studies was conducted according to the methodological standard of the Joanna Briggs Institute, based on a systematic literature search in the databases MEDLINE, CINAHL, Social Sciences Citation Index and LIVIVO (5/2023). Results: Twenty-nine studies were included. From these, nine syntheses were aggregated, seven of which related to life after a critical illness and two to the experience of aftercare. For patients and their relatives, everyday life changes after return to home. They are facing the challenge of realigning their lives, coming to terms with permanent changes and accepting them as the new normal life. Patients also experience breaks in their aftercare and want access to aftercare services. Conclusions: The meta-synthesis depicts life after a critical illness in a variety of ways. Aftercare programs should therefore combine various services and take relatives into account, as they enable care at home.
doi: 10.1024/1012-5302/a001032
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Flügge K
      type: Person
      first name: Katrin
      last name: Flügge
      member of: Institut für Gesundheits- und Pflegewissenschaft, Martin-Luther-Universität Halle-Wittenberg, Deutschland.
  slot:
    index: 2
    item: Meyer G
      type: Person
      first name: Gabriele
      last name: Meyer
      member of: Institut für Gesundheits- und Pflegewissenschaft, Martin-Luther-Universität Halle-Wittenberg, Deutschland.
  slot:
    index: 3
    item: Berg A
      type: Person
      first name: Almuth
      last name: Berg
      member of: Institut für Gesundheits- und Pflegewissenschaft, Martin-Luther-Universität Halle-Wittenberg, Deutschland.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T02:42
ISSN: 1012-5302
has issn l: 1012-5302
has NLM journal title abbreviation: Pflege
publication name: Pflege
language: ger
has national library of medicine journal id: 8907069
rights holder: Zusammenfassung: Hintergrund: Durch verbesserte intensivmedizinische Behandlungsoptionen überleben immer mehr Menschen eine kritische Erkrankung. Rund 50% sind jedoch von Langzeitfolgen betroffen, die unter dem Post Intensive Care Syndrome (PICS) zusammengefasst werden und die Notwendigkeit intensivstationärer Nachsorge verdeutlichen. Fragestellung: Wie nehmen Betroffene und ihre Angehörigen das Leben nach einer intensivstationären kritischen Erkrankung und die Nachsorge wahr? Methoden: Es wurde eine Meta-Synthese qualitativer Studien gemäß dem methodischen Standard des Joanna Briggs Institute, basierend auf einer systematischen Literaturrecherche in den Datenbanken MEDLINE, CINAHL, Social Sciences Citation Index und LIVIVO (5/2023) durchgeführt. Ergebnisse: Es wurden 29 Studien eingeschlossen. Aus diesen wurden neun Synthesen komprimiert, wovon sich sieben auf das Leben nach einer kritischen Erkrankung und zwei auf das Erleben der Nachsorge beziehen. Für Betroffene und ihre Angehörigen ändert sich der Alltag mit der Rückkehr nach Hause. Sie stehen vor der Herausforderung, ihr Leben neu auszurichten, sich mit bleibenden Veränderungen zu arrangieren und diese als neue Normalität zu akzeptieren. Betroffene erleben zudem Brüche in der Nachsorge und wünschen sich Zugang zu Nachsorgeangeboten. Schlussfolgerungen: Die Meta-Synthese stellt das Leben nach einer kritischen Erkrankung auf vielfältige Weise dar. In Nachsorgeprogrammen sollten daher verschiedene Angebote kombiniert und auch Angehörige berücksichtigt werden, da sie die Versorgung zuhause ermöglichen.
derived from: NLM
has place of publication: Switzerland
source: Pflege. 2025-02-14;():.

Traveling waves in a free boundary problem for the spread of ecosystem engineers.
pmid: 39949167
abstract: Reaction-diffusion equations are a trusted modeling framework for the dynamics of biological populations in space and time, and their traveling wave solutions are interpreted as the density of an invasive species that spreads at constant speed. Even though certain species can significantly alter their abiotic environment for their benefit, and even though some of these so-called ecosystem engineers are among the most destructive invasive species, most models neglect this feedback. Here, we extended earlier work that studied traveling waves of ecosystem engineers with a logistic growth function to study the existence of traveling waves in the presence of a strong Allee effect. Our model consisted of suitable and unsuitable habitat, each a semi-infinite interval, separated by a moving interface. The speed of this boundary depended on the engineering activity of the species. On each of the intervals, we had a reaction-diffusion equation for the population density, and at the interface, we had matching conditions for density and flux. We used phase-plane analysis to detect and classify several qualitatively different types of traveling waves, most of which have previously not been described. We gave conditions for their existence for different biological scenarios of how individuals alter their abiotic environment. As an intermediate step, we studied the existence of traveling waves in a so-called moving habitat model , which can be interpreted as a model for the effects of climate change on the spatial dynamics of populations.
doi: 10.3934/mbe.2025008
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Basiri M
      type: Person
      first name: Maryam
      last name: Basiri
      member of: Department of Mathematics and Statistics, University of Ottawa, Ottawa, Canada.Department of Mathematics, Toronto Metropolitan University, Toronto, Canada.
  slot:
    index: 2
    item: Lutscher F
      type: Person
      first name: Frithjof
      last name: Lutscher
      member of: Department of Mathematics and Statistics, University of Ottawa, Ottawa, Canada.Department of Biology, University of Ottawa, Ottawa, Canada.
  slot:
    index: 3
    item: Moameni A
      type: Person
      first name: Abbas
      last name: Moameni
      member of: School of Mathematics and Statistics, Carleton University, Ottawa, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01-03
dp: 2025 Jan 03
created: 2025-2-14T02:42
e ISSN: 1551-0018
has issn l: 1547-1063
issue: 1
has NLM journal title abbreviation: Math Biosci Eng
publication name: Mathematical biosciences and engineering : MBE
language: eng
has national library of medicine journal id: 101197794
derived from: NLM
starting page: 152
ending page: 184
has place of publication: United States
source: Math Biosci Eng. 2025-01-03;22(1):152-184.
volume: 22

Probabilistic prediction intervals of short-term wind speed using selected features and time shift dependent machine learning models.
pmid: 39949161
abstract: Forecasting wind speed plays an increasingly essential role in the wind energy industry. However, wind speed is uncertain with high changeability and dependency on weather conditions. Variability of wind energy is directly influenced by the fluctuation and unpredictability of wind speed. Traditional wind speed prediction methods provide deterministic forecasting that fails to estimate the uncertainties associated with wind speed predictions. Modeling those uncertainties is important to provide reliable information when the uncertainty level increases. Models for estimating prediction intervals of wind speed do not differentiate between daytime and nighttime shifts, which can affect the performance of probabilistic wind speed forecasting. In this paper, we introduce a prediction framework for deterministic and probabilistic short-term wind speed forecasting. The designed framework incorporates independent machine learning (ML) models to estimate point and interval prediction of wind speed during the daytime and nighttime shifts, respectively. First, feature selection techniques were applied to maintain the most relevant parameters in the datasets of daytime and nighttime shifts, respectively. Second, support vector regressors (SVRs) were used to predict the wind speed 10 minutes ahead. After that, we incorporated the non-parametric kernel density estimation (KDE) method to statistically synthesize the wind speed prediction errors and estimate the prediction intervals (PI) with several confidence levels. The simulation results validated the effectiveness of our framework and demonstrated that it can generate prediction intervals that are satisfactory in all evaluation criteria. This verifies the validity and feasibility of the hypothesis of separating the daytime and nighttime data sets for these types of predictions.
doi: 10.3934/mbe.2025002
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Al-Hajj R
      type: Person
      first name: Rami
      last name: Al-Hajj
      member of: College of Engineering and Technology, American University of the Middle East, Kuwait.
  slot:
    index: 2
    item: Oskrochi G
      type: Person
      first name: Gholamreza
      last name: Oskrochi
      member of: College of Engineering and Technology, American University of the Middle East, Kuwait.
  slot:
    index: 3
    item: Fouad MM
      type: Person
      first name: Mohamad M
      last name: Fouad
      member of: Faculty of Engineering, Mansoura University, Egypt.
  slot:
    index: 4
    item: Assi A
      type: Person
      first name: Ali
      last name: Assi
      member of: Independent Researcher, SMIEEE-Renewable Energy, Quebec, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01
dp: 2025 Jan
created: 2025-2-14T02:42
e ISSN: 1551-0018
has issn l: 1547-1063
issue: 1
has NLM journal title abbreviation: Math Biosci Eng
publication name: Mathematical biosciences and engineering : MBE
language: eng
has national library of medicine journal id: 101197794
derived from: NLM
starting page: 23
ending page: 51
has place of publication: United States
source: Math Biosci Eng. 2025-01;22(1):23-51.
volume: 22

Robust control and data reconstruction for nonlinear epidemiological models using feedback linearization and state estimation.
pmid: 39949165
abstract: It has been clearly demonstrated over the past years that control theory can provide an efficient framework for the solution of several complex tasks in epidemiology. In this paper, we present a computational approach for the state estimation based reference tracking control and historical data reconstruction using nonlinear compartmental epidemic models. The control model is given in nonlinear input-affine form, where the manipulable input is the disease transmission rate influenced by possible measures and restrictions, while the observed or computed output is the number of infected people. The control design is built around a simple SEIR model and relies on a feedback linearization technique. We examine and compare different control setups distinguished by the availability of state information, complementing the directly measurable data with an extended Kalman filter used for state estimation. To illustrate the capabilities and robustness of the proposed method, we carry out multiple case studies for output tracking and data reconstruction on Swedish and Hungarian data, all in the presence of serious model and parameter mismatch. Computation results show that a well-designed feedback, even in the presence of significant observation uncertainties, can sufficiently reduce the effect of modeling errors.
doi: 10.3934/mbe.2025006
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Csutak B
      type: Person
      first name: Balázs
      last name: Csutak
      member of: Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50/A, H-1083, Budapest, Hungary.
  slot:
    index: 2
    item: Szederkényi G
      type: Person
      first name: Gábor
      last name: Szederkényi
      member of: Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50/A, H-1083, Budapest, Hungary.Systems and Control Laboratory, HUN-REN Institute for Computer Science and Control, Kende u. 13-17, H-1111, Budapest, Hungary.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-01-02
dp: 2025 Jan 02
created: 2025-2-14T02:42
e ISSN: 1551-0018
has issn l: 1547-1063
issue: 1
has NLM journal title abbreviation: Math Biosci Eng
publication name: Mathematical biosciences and engineering : MBE
language: eng
has national library of medicine journal id: 101197794
derived from: NLM
starting page: 109
ending page: 137
has place of publication: United States
source: Math Biosci Eng. 2025-01-02;22(1):109-137.
volume: 22

Stochastic models of population growth.
pmid: 39949160
abstract: We considered three types of stochastic models of a single population growth: with diffusion-type noise; with parameters replaced by stochastic processes; and with random jumps describing a sudden decrease in population size. We presented methods for studying stochastic processes modeling population growth, in particular, the long-time behavior of sample paths and their distributions. We were especially interested in the asymptotic stability of the density of the distributions of these processes. We gave biological interpretations, examples, and numerical simulations of theoretical methods and results.
doi: 10.3934/mbe.2025001
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Pichór K
      type: Person
      first name: Katarzyna
      last name: Pichór
      member of: Institute of Mathematics, University of Silesia, Bankowa 14, 40-007 Katowice, Poland.
  slot:
    index: 2
    item: Sanaei P
      type: Person
      first name: Pejman
      last name: Sanaei
      member of: Institute of Mathematics, Polish Academy of Sciences, Bankowa 14, 40-007 Katowice, Poland.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-01
dp: 2025 Jan
created: 2025-2-14T02:42
e ISSN: 1551-0018
has issn l: 1547-1063
issue: 1
has NLM journal title abbreviation: Math Biosci Eng
publication name: Mathematical biosciences and engineering : MBE
language: eng
has national library of medicine journal id: 101197794
derived from: NLM
starting page: 1
ending page: 22
has place of publication: United States
source: Math Biosci Eng. 2025-01;22(1):1-22.
volume: 22

Computational physics and imaging in medicine.
pmid: 39949164
doi: 10.3934/mbe.2025005
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Chow JCL
      type: Person
      first name: James C L
      last name: Chow
      member of: Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.Temerty Centre for AI Research and Education in Medicine, University of Toronto, Toronto, Ontario, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01-02
dp: 2025 Jan 02
created: 2025-2-14T02:42
e ISSN: 1551-0018
has issn l: 1547-1063
issue: 1
has NLM journal title abbreviation: Math Biosci Eng
publication name: Mathematical biosciences and engineering : MBE
language: eng
has national library of medicine journal id: 101197794
derived from: NLM
starting page: 106
ending page: 108
has place of publication: United States
source: Math Biosci Eng. 2025-01-02;22(1):106-108.
volume: 22

Towards more sustainable oceans: A review of the pressing challenges posed by marine plastic litter.
pmid: 39949180
abstract: Marine littering is a global challenge and a significant threat to a sustainable planet, requiring comprehensive and effective mechanisms to address it in a comprehensive manner. This study reports on a bibliometric analysis that has identified the extent to which the topic has been explored in the international literature, by focusing on geographical scope, the emphasis on (micro)plastic litter and on policy measures. Additionally, as a complement to the assessment of the recent literature on marine plastic litter, this study reviews some case studies, identifying some trends on how to cope with this problem. The findings underscore the imperative for heightened research efforts in the context of marine littering. The literature reveals that unsustainable practices, the absence of robust policies and inadequate enforcement substantially contribute to the prevalence of marine plastic litter. Consequently, urgent action is essential, demanding the implementation of effective policies and frameworks. Encouraging nations to transition towards marine sustainability, particularly in terms of prevention and environmental awareness, is of paramount importance. To pave the way for a cleaner ocean for future generations, this study not only highlights the root causes but also offers suggested solutions. These solutions serve as valuable insights for researchers, innovators and policymakers worldwide, charting a course towards a more sustainable and litter-free marine environment.
doi: 10.1177/0734242X251313927
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Leal Filho W
      type: Person
      first name: Walter
      last name: Leal Filho
      member of: International Climate Change Information and Research Programme, Research and Transfer Centre 'Sustainable Development and Climate Change Management', Hamburg University of Applied Sciences, Germany.Department of Natural Sciences, Manchester Metropolitan University, Manchester, UK.
  slot:
    index: 2
    item: Barbir J
      type: Person
      first name: Jelena
      last name: Barbir
      member of: Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany.
  slot:
    index: 3
    item: May J
      type: Person
      first name: Julia
      last name: May
      member of: International Climate Change Information and Research Programme, Research and Transfer Centre 'Sustainable Development and Climate Change Management', Hamburg University of Applied Sciences, Germany.
  slot:
    index: 4
    item: May M
      type: Person
      first name: Marta
      last name: May
      member of: International Climate Change Information and Research Programme, Research and Transfer Centre 'Sustainable Development and Climate Change Management', Hamburg University of Applied Sciences, Germany.
  slot:
    index: 5
    item: Swart J
      type: Person
      first name: Julia
      last name: Swart
      member of: Utrecht School of Economics, Utrecht University, Utrecht, The Netherlands.
  slot:
    index: 6
    item: Yang P
      type: Person
      first name: Peter
      last name: Yang
      member of: Great Lake Energy Institute, Case Western Reserve University, Cleveland, OH, USA.
  slot:
    index: 7
    item: Dinis MAP
      type: Person
      first name: Maria Alzira Pimenta
      last name: Dinis
      member of: UFP Energy, Research, Innovation and Development Unit (FP-I3ID), University Fernando Pessoa (UFP), Porto, Portugal.Marine and Environmental Sciences Centre (MARE), University of Coimbra, Edifício do Patronato, Coimbra, Portugal.
  slot:
    index: 8
    item: Aina YA
      type: Person
      first name: Yusuf A
      last name: Aina
      member of: Department of Geomatics Engineering Technology, Yanbu Industrial College, Yanbu, Saudi Arabia.
  slot:
    index: 9
    item: Bettencourt S
      type: Person
      first name: Sara
      last name: Bettencourt
      member of: Center for Global Studies (CEG), Department of Science and Technology, Portuguese Distance Learning University (UAb), Lisbon, Portugal.Center for Environmental and Sustainability Research (CENSE), School of Science and Technology, NOVA University of Lisbon, Lisbon, Portugal.MARE, Aquatic Research Network (ARNET), Regional Agency for the Development of Research, Technology and Innovation (ARDITI), Madeira, Portugal.Faculty of Life Sciences, University of Madeira, Madeira, Portugal.
  slot:
    index: 10
    item: Charvet P
      type: Person
      first name: Patricia
      last name: Charvet
      member of: Programa de Pós-Graduação em Sistemática, Uso e Conservação da Biodiversidade (PPGSis), Departamento de Biologia, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.Programa de Pós-Graduação em Engenharia Ambiental (PPGEA), Departamento de Engenharia Ambiental, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.
  slot:
    index: 11
    item: Azadi H
      type: Person
      first name: Hossein
      last name: Azadi
      member of: Department of Economics and Rural Development, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:54
e ISSN: 1096-3669
has NLM journal title abbreviation: Waste Manag Res
publication name: Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA
language: eng
has national library of medicine journal id: 9881064
derived from: NLM
pg: 734242X251313927
has place of publication: England
source: Waste Manag Res. 2025-02-13;():734242X251313927.

Anti-proliferative and anti-migratory effects of Urtica dioica agglutinin loaded chitosan nanoparticles with hyaluronic acid coating on the CD44-overexpressing prostate cancer cells.
pmid: 39949169
abstract: Urtica dioica agglutinin (UDA), a plant macromolecule with biological properties, shows promise for cancer treatment. Hyaluronic acid (HA), which binds to the CD44 receptor commonly found on cancer cells, can enhance drug delivery. This study investigates the anti-proliferative and anti-migratory potential of UDA encapsulated in chitosan (CS) nanoparticles coated with HA against CD44-overexpressing prostate cancer cells. In vitro tests showed that UDA-CS-HA nanoparticles had more significant cytotoxic effects on PC3 cells at concentrations above 150 µg/mL compared to UDA-CS. They also inhibited wound healing at 100 µg/mL and higher. Higher UDA-CS-HA concentrations correlated with increased CD44 and Nanog expression levels, indicating CD44 pathway activation. These findings suggest that UDA-CS-HA nanoparticles, likely due to their enhanced uptake by CD44 receptors, can function as targeted carriers with combined anti-proliferative and anti-migratory potential against CD44-overexpressing cancers. .
doi: 10.1080/09603123.2025.2465877
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Heydari M
      type: Person
      first name: Mohammadkazem
      last name: Heydari
      member of: Department of Molecular and Cell Biology, Faculty of Science, University of Mazandaran, Babolsar, Mazandaran, Iran.
  slot:
    index: 2
    item: Hosseinzadeh Colagar A
      type: Person
      first name: Abasalt
      last name: Hosseinzadeh Colagar
      member of: Department of Molecular and Cell Biology, Faculty of Science, University of Mazandaran, Babolsar, Mazandaran, Iran.
  slot:
    index: 3
    item: Sabour D
      type: Person
      first name: Davood
      last name: Sabour
      member of: Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran.Department of Cancer Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Babol, Iran.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T02:42
e ISSN: 1369-1619
has issn l: 0960-3123
has NLM journal title abbreviation: Int J Environ Health Res
publication name: International journal of environmental health research
language: eng
has national library of medicine journal id: 9106628
derived from: NLM
starting page: 1
ending page: 15
has place of publication: England
source: Int J Environ Health Res. 2025-02-13;():1-15.

Regarding the Association Between Polycystic Ovary Syndrome and Risk of Pre-Eclampsia.
pmid: 39949190
doi: 10.1111/1471-0528.18087
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Li H
      type: Person
      first name: Hong
      last name: Li
      member of: Department of Gynecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  slot:
    index: 2
    item: He J
      type: Person
      first name: Jue
      last name: He
      member of: Department of Gynecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  slot:
    index: 3
    item: Xu Y
      type: Person
      first name: Yan
      last name: Xu
      member of: Department of Gynecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  slot:
    index: 4
    item: Yi M
      type: Person
      first name: Minhui
      last name: Yi
      member of: Department of Gynecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  slot:
    index: 5
    item: Qin Y
      type: Person
      first name: Yan
      last name: Qin
      member of: Department of Gynecology and Obstetrics, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T03:03
e ISSN: 1471-0528
has issn l: 1470-0328
has NLM journal title abbreviation: BJOG
publication name: BJOG : an international journal of obstetrics and gynaecology
language: eng
has national library of medicine journal id: 100935741
derived from: NLM
has place of publication: England
source: BJOG. 2025-02-13;():.

Routine-data-compatible quality indicators for the ambulatory care of osteoarthritis of the knee and hip: A systematic review.
pmid: 39949191
abstract: Germany has high rates of total joint arthroplasty for osteoarthritis of the knee and hip. Ambulatory health interventions can affect the progression of these conditions and the need for total joint arthroplasty. Quality indicators and guideline recommendations facilitate the transparent measurement and demonstration of care quality. Therefore, a systematic literature review of quality indicators and guideline recommendations for ambulatory care of osteoarthritis of the knee and hip before total joint arthroplasty was conducted, focusing on those that could be quantified using routine data from German statutory health insurers.Five electronic databases for quality indicators and guidelines published between 2000 and 2021 related to the ambulatory management of osteoarthritis of the knee and hip before total joint arthroplasty were searched. Two reviewers independently selected and appraised the quality of the studies. To synthesise a routine-data-compatible set of quality indicators, similarities and differences among existing quality indicator sets and guideline recommendations were identified and resolved.This systematic search yielded 10,841 potentially relevant records, leading to the identification of 20 sets of quality indicators and 35 guidelines with measures quantifiable using routine data. The present evidence synthesis produced 24 routine-data-compatible process quality indicators related to the type, order or frequency of musculoskeletal appointments, diagnostic imaging procedures, referrals to physical therapists and pharmaceutical prescriptions.The synthesised set of routine-data-compatible quality indicators can provide a resource-saving tool for offering individual feedback to physicians on the processes involved in the ambulatory management of osteoarthritis of the knee and hip. Engaging in interdisciplinary discussions on variations in quality indicator outcomes could contribute to improving interdisciplinary physician collaboration in ambulatory c[cell cut: 2035 characters, first 2000 kept]
rights: © 2025 The Author(s). Knee Surgery, Sports Traumatology, Arthroscopy published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy.
doi: 10.1002/ksa.12614
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Bock T
      type: Person
      first name: Tobias
      last name: Bock
      member of: Department of Health Economics, Technical University of Munich, Munich, Germany.
  slot:
    index: 2
    item: Flemming R
      type: Person
      first name: Ronja
      last name: Flemming
      member of: Department of Health Economics, Technical University of Munich, Munich, Germany.
  slot:
    index: 3
    item: Bammert P
      type: Person
      first name: Philip
      last name: Bammert
      member of: Department of Health Economics, Technical University of Munich, Munich, Germany.
  slot:
    index: 4
    item: von Eisenhart-Rothe R
      type: Person
      first name: Rüdiger
      last name: von Eisenhart-Rothe
      member of: Department of Orthopaedics and Sport Orthopaedics, University Hospital rechts der Isar, Technical University Munich, Munich, Germany.
  slot:
    index: 5
    item: Hirschmann MT
      type: Person
      first name: Michael T
      last name: Hirschmann
      member of: Department of Orthopaedic Surgery and Traumatology, Kantonsspital Baselland (Bruderholz, Liestal, Laufen), University of Basel, Basel, Switzerland.
  slot:
    index: 6
    item: Sundmacher L
      type: Person
      first name: Leonie
      last name: Sundmacher
      member of: Department of Health Economics, Technical University of Munich, Munich, Germany.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T03:03
e ISSN: 1433-7347
has issn l: 0942-2056
has NLM journal title abbreviation: Knee Surg Sports Traumatol Arthrosc
publication name: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
language: eng
has national library of medicine journal id: 9314730
derived from: NLM
has place of publication: Germany
source: Knee Surg Sports Traumatol Arthrosc. 2025-02-13;():.

At the grass roots: non-destructive root phenotyping using X-ray computed tomography.
pmid: 39949204
doi: 10.1111/tpj.70030
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kirschner GK
      type: Person
      first name: Gwendolyn K
      last name: Kirschner
      member of: Laboratory of Plant Cell and Developmental Biology, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T03:04
e ISSN: 1365-313X
has issn l: 0960-7412
issue: 3
has NLM journal title abbreviation: Plant J
publication name: The Plant journal : for cell and molecular biology
language: eng
has national library of medicine journal id: 9207397
derived from: NLM
pg: e70030
has place of publication: England
source: Plant J. 2025-02;121(3):e70030.
volume: 121

Benefits of Using Intensive Short-Term Dynamic Psychotherapy in Psychiatric Practice.
pmid: 39949216
abstract: Psychiatry residency programs in the United States and Canada currently require trainees to demonstrate competency in psychodynamic therapy. Developed by Habib Davanloo, intensive short-term dynamic psychotherapy (ISTDP) is a brief psychodynamic therapy with emerging evidence to support its efficacy as an evidence-based, cost-effective treatment for various common psychiatric disorders and personality pathologies. Davanloo's metapsychology of the unconscious offers a way to understand the psychodynamic processes that maintain patients' psychiatric symptoms. Some key clinical processes unique to ISTDP facilitate conceptualization of patients' problems and allow for effective interventions. ISTDP skills can be especially helpful when working with populations with complex and treatment-resistant conditions that are commonly encountered in psychiatric secondary- and tertiary-care settings. This article aims to examine the value of ISTDP training for psychiatrists. First, the benefits of being able to offer formal treatment with ISTDP are examined. Second, the unique skills acquired through ISTDP training, which can be used in general psychiatric care, are reviewed. Finally, the personal and systemic benefits of ISTDP training, including clinician self-monitoring, management of burnout, and team leadership, are discussed.
doi: 10.1176/appi.psychotherapy.20240040
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Hofner A
      type: Person
      first name: Anna
      last name: Hofner
      member of: Discipline of Psychiatry, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada (Hofner); Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada (Bawks).
  slot:
    index: 2
    item: Bawks J
      type: Person
      first name: Jordan
      last name: Bawks
      member of: Discipline of Psychiatry, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada (Hofner); Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada (Bawks).
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:14
ISSN: 0002-9564
has issn l: 0002-9564
has NLM journal title abbreviation: Am J Psychother
publication name: American journal of psychotherapy
language: eng
has national library of medicine journal id: 0110672
derived from: NLM
pg: appipsychotherapy20240040
has place of publication: United States
source: Am J Psychother. 2025-02-14;():appipsychotherapy20240040.

On the inference of red blood cell size from fossils.
pmid: 39949201
doi: 10.1002/ar.25645
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Udroiu I
      type: Person
      first name: Ion
      last name: Udroiu
      member of: Dipartimento di Scienze, Università degli Studi Roma Tre, Rome, Italy.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T03:03
e ISSN: 1932-8494
has issn l: 1932-8486
has NLM journal title abbreviation: Anat Rec (Hoboken)
publication name: Anatomical record (Hoboken, N.J. : 2007)
language: eng
has national library of medicine journal id: 101292775
derived from: NLM
has place of publication: United States
source: Anat Rec (Hoboken). 2025-02-13;():.

Management of Lateral Condyle Humeral Fracture Associated With Elbow Dislocation in Children: A Retrospective International Multicenter Cohort Study.
pmid: 39949208
has PII: 01241398-990000000-00764
doi: 10.1097/BPO.0000000000002927
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Li X
      type: Person
      first name: Xiongtao
      last name: Li
      member of: Department of Orthopedics Surgery Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:13
e ISSN: 1539-2570
has issn l: 0271-6798
has NLM journal title abbreviation: J Pediatr Orthop
publication name: Journal of pediatric orthopedics
language: eng
has national library of medicine journal id: 8109053
derived from: NLM
has place of publication: United States
source: J Pediatr Orthop. 2025-02-14;():.

Identifying Risk Factors for Open Reduction in Pediatric Supracondylar Humerus Fractures.
pmid: 39949214
has PII: 01241398-990000000-00763
doi: 10.1097/BPO.0000000000002928
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Rehm A
      type: Person
      first name: Andreas
      last name: Rehm
      member of: Department of Paediatric Orthopaedics, Cambridge University Hospitals NHS Foundation Trust.
  slot:
    index: 2
    item: Osman H
      type: Person
      first name: Hatem
      last name: Osman
      member of: Department of Paediatric Orthopaedics, Cambridge University Hospitals NHS Trust, Cambridge.
  slot:
    index: 3
    item: Worley RJ
      type: Person
      first name: Rebecca J
      last name: Worley
      member of: Department of Paediatric Orthopaedics, Cambridge University Hospitals NHS Foundation Trust.
  slot:
    index: 4
    item: Newton AC
      type: Person
      first name: Ayla C
      last name: Newton
      member of: Department of Paediatric Orthopaedics, Cambridge University Hospitals NHS Foundation Trust.
  slot:
    index: 5
    item: Chase HE
      type: Person
      first name: Helen E
      last name: Chase
      member of: Department of Paediatric Orthopaedics, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich & West Suffolk Hospital, Bury St Edmunds, UK.
  slot:
    index: 6
    item: Granger L
      type: Person
      first name: Luke
      last name: Granger
      member of: Department of Paediatric Orthopaedics, Cambridge University Hospitals NHS Foundation Trust.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:13
e ISSN: 1539-2570
has issn l: 0271-6798
has NLM journal title abbreviation: J Pediatr Orthop
publication name: Journal of pediatric orthopedics
language: eng
has national library of medicine journal id: 8109053
derived from: NLM
has place of publication: United States
source: J Pediatr Orthop. 2025-02-14;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39949221
pmid: 39949221
has PII: RMS0905-001
doi: 10.53738/REVMED.2025.21.905.259
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Prada P
      type: Person
      first name: Paco
      last name: Prada
      member of: Service de psychiatrie de liaison et d'intervention de crise, Département de psychiatrie, Hôpitaux universitaires de Genève.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
pg: 259
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):259.
volume: 21

http://rdf.ncbi.nlm.nih.gov/pubmed/39949229
pmid: 39949229
has PII: RMS0905-009
doi: 10.53738/REVMED.2025.21.905.291
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Samer C
      type: Person
      first name: Caroline
      last name: Samer
      member of: Professeure associée, Médecin cheffe de service, Responsable de l'Unité de pharmacogénomique et de thérapies personnalisées aux Hôpitaux universitaires de Genève, Présidente de la Société suisse de pharmacologie et toxicologie cliniques.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
starting page: 291
ending page: 292
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):291-292.
volume: 21

http://rdf.ncbi.nlm.nih.gov/pubmed/39949231
pmid: 39949231
has PII: RMS0905-011
doi: 10.53738/REVMED.2025.21.905.295
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Baras A
      type: Person
      first name: Alice
      last name: Baras
      member of: Professionnelle de santé durable, Chirurgienne-dentiste, ECOPS Conseil, 59370 Mons en Baroeul, France.
  slot:
    index: 2
    item: Diserens M
      type: Person
      first name: Marius
      last name: Diserens
      member of: Département promotion de la santé et préventions, Centre universitaire de médecine générale et santé publique, Unisanté, 1011 Lausanne.
  slot:
    index: 3
    item: Tarteret P
      type: Person
      first name: Paul
      last name: Tarteret
      member of: Département de santé globale et environnementale, Centre universitaire de médecine générale et de santé publique, Unisanté, 1011 Lausanne.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
starting page: 295
ending page: 297
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):295-297.
volume: 21

http://rdf.ncbi.nlm.nih.gov/pubmed/39949232
pmid: 39949232
has PII: RMS0905-012
doi: 10.53738/REVMED.2025.21.905.298
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Castelli G
      type: Person
      first name: Giulia
      last name: Castelli
      member of: Unisanté, Lausanne.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
pg: 298
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):298.
volume: 21

http://rdf.ncbi.nlm.nih.gov/pubmed/39949233
pmid: 39949233
has PII: RMS0905-013
doi: 10.53738/REVMED.2025.21.905.298
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Gennart M
      type: Person
      first name: Michèle
      last name: Gennart
      member of: Psychologue spécialiste en psychothérapie, Centre médical de La Source, Av. Vinet 30, 1004 Lausanne.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
starting page: 298
ending page: 299
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):298-299.
volume: 21

http://rdf.ncbi.nlm.nih.gov/pubmed/39949235
pmid: 39949235
has PII: RMS0905-015
doi: 10.53738/REVMED.2025.21.905.300
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Lovis C
      type: Person
      first name: Christian
      last name: Lovis
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
pg: 300
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):300.
volume: 21

http://rdf.ncbi.nlm.nih.gov/pubmed/39949234
pmid: 39949234
has PII: RMS0905-014
doi: 10.53738/REVMED.2025.21.905.299
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Villat K
      type: Person
      first name: Kevin
      last name: Villat
      member of: Avec la collaboration du groupe MIAjour, Service de médecine interne, Centre hospitalier universitaire vaudois, Lausanne.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-12
dp: 2025 Feb 12
created: 2025-2-14T03:23
ISSN: 1660-9379
has issn l: 1660-9379
issue: 905
has NLM journal title abbreviation: Rev Med Suisse
publication name: Revue medicale suisse
language: fre
has national library of medicine journal id: 101219148
derived from: NLM
pg: 299
has place of publication: Switzerland
source: Rev Med Suisse. 2025-02-12;21(905):299.
volume: 21

Gestational Diabetes Mellitus and the Longitudinal Fetal Growth Trajectories in Twin Pregnancies.
pmid: 39949264
abstract: Although it is well established that gestational diabetes mellitus (GDM) is associated with fetal overgrowth in singleton pregnancies, little is known about its role in twins. We aimed to explore the relationship between GDM and the longitudinal fetal growth in twin pregnancies. This was a retrospective matched cohort study of GDM and non-GDM twin pregnancies delivered ≥36 weeks without other complications. All the women performed ≥3 ultrasounds after 22 weeks. Linear mixed models (LMMs) were used to explore the relationships between longitudinal fetal growth trajectories and GDM. Group-based trajectory modeling (GBTM) and generalized estimating equation (GEE) were applied to identify the latent growth patterns and investigate their relationships with GDM. In total, 215 GDM and 645 non-GDM twins were included, the majority of the patients did not require medication therapy (n = 202, GDMA1). LMM revealed that, compared with non-GDM, GDM was associated with an average increase in fetal weight of 4.36 g (95% CI [1.25, 7.48]) per week. GBTM and GEE further revealed that GDM increased the odds of fetal weight trajectory to nearly 40% of the total fetal weight trajectory, classified into the high-speed group (aOR = 1.39, 95% CI [1.03, 1.88]), associating with a 49.44 g (95% CI [11.41, 87.48]) increase in birth weight. Subgroup analysis revealed that all these differences were only significant among the GDMA1 pregnancies (p < .05). GDM (GDMA1) is significantly associated with an increase in fetal weight during gestation in twin pregnancies. However, this acceleration is mild, and its significance requires further exploration.
has PII: S1832427425000064
doi: 10.1017/thg.2025.6
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Shu X
      type: Person
      first name: Xinyu
      last name: Shu
      member of: Department of Obstetrics and Gynecology and Reproductive Medicine, Peking University First Hospital, Beijing, China.
  slot:
    index: 2
    item: Yao M
      type: Person
      first name: Mi
      last name: Yao
      member of: Department of General Practice, Peking University First Hospital, Beijing, China.
  slot:
    index: 3
    item: Li C
      type: Person
      first name: Chenglong
      last name: Li
      member of: Department of National Institute of Health Data Science, Peking University, Beijing, China.
  slot:
    index: 4
    item: Chen N
      type: Person
      first name: Na
      last name: Chen
      member of: Department of Obstetrics and Gynecology, The Hospital of Cang Town, Cangzhou, Hebei Province, China.
  slot:
    index: 5
    item: Zhang Y
      type: Person
      first name: Yan
      last name: Zhang
      member of: Department of Pediatrics, Capital Medical University Daxing Teaching Hospital, Beijing, China.
  slot:
    index: 6
    item: Kang X
      type: Person
      first name: Xin
      last name: Kang
      member of: Department of Obstetrics and Gynecology and Reproductive Medicine, Peking University First Hospital, Beijing, China.
  slot:
    index: 7
    item: Juan J
      type: Person
      first name: Juan
      last name: Juan
      member of: Department of Obstetrics and Gynecology and Reproductive Medicine, Peking University First Hospital, Beijing, China.
  slot:
    index: 8
    item: Yang H
      type: Person
      first name: Huixia
      last name: Yang
      member of: Department of Obstetrics and Gynecology and Reproductive Medicine, Peking University First Hospital, Beijing, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:34
ISSN: 1832-4274
has issn l: 1832-4274
has NLM journal title abbreviation: Twin Res Hum Genet
publication name: Twin research and human genetics : the official journal of the International Society for Twin Studies
language: eng
has national library of medicine journal id: 101244624
derived from: NLM
starting page: 1
ending page: 7
has place of publication: England
source: Twin Res Hum Genet. 2025-02-14;():1-7.

Malaria microscopy: a challenge in malaria elimination.
pmid: 39949258
has PII: 8015273
doi: 10.1093/trstmh/traf014
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Singh RK
      type: Person
      first name: Ranjan Kumar
      last name: Singh
      member of: Physician, Manserpur, P.O. Lakhminia, Begusarai 851211, Bihar, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:33
e ISSN: 1878-3503
has issn l: 0035-9203
has NLM journal title abbreviation: Trans R Soc Trop Med Hyg
publication name: Transactions of the Royal Society of Tropical Medicine and Hygiene
language: eng
has national library of medicine journal id: 7506129
derived from: NLM
has place of publication: England
source: Trans R Soc Trop Med Hyg. 2025-02-14;():.

Effectiveness of Janus Kinase Inhibitors for the Management of Atopic Dermatitis and Concomitant Occupational Allergic Contact Dermatitis: A Real-Life Study.
pmid: 39949280
doi: 10.1089/derm.2024.0539
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Potestio L
      type: Person
      first name: Luca
      last name: Potestio
      member of: Section of Dermatology-Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  slot:
    index: 2
    item: Patruno C
      type: Person
      first name: Cataldo
      last name: Patruno
      member of: Department of Medicine and Health Sciences Vincenzo Tiberio , University of Molise, Campobasso, Italy.
  slot:
    index: 3
    item: Feo F
      type: Person
      first name: Federica
      last name: Feo
      member of: Section of Dermatology-Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  slot:
    index: 4
    item: Coronella L
      type: Person
      first name: Luigi
      last name: Coronella
      member of: Section of Dermatology-Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  slot:
    index: 5
    item: di Vico F
      type: Person
      first name: Francesca
      last name: di Vico
      member of: Section of Dermatology-Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  slot:
    index: 6
    item: Napolitano M
      type: Person
      first name: Maddalena
      last name: Napolitano
      member of: Section of Dermatology-Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:43
e ISSN: 2162-5220
has issn l: 1710-3568
has NLM journal title abbreviation: Dermatitis
publication name: Dermatitis : contact, atopic, occupational, drug
language: eng
has national library of medicine journal id: 101207335
derived from: NLM
has place of publication: United States
source: Dermatitis. 2025-02-14;():.

Crestal approach for repair of oroantral bone defects and subsequent implant placement.
pmid: 39949282
abstract: Oroantral communication (OAC) can occur after a dental extraction. Occasionally, bony defects may persist despite successful soft tissue closure of the OAC. The absence of bone in these areas poses challenges for dental implant placement. This report describes a novel approach of vertical sinus elevation through the oroantral bony defect to address such scenarios.A 36-year-old male (Patient 1) and a 62-year-old female (Patient 2) presented with OACs in the first maxillary molar region. Vertical sinus elevation was achieved through the existing defect. This was followed by placement of corticocancellous bone allograft mixed with platelet-rich fibrin (PRF) in the space surrounded by the elevated sinus membrane that was then covered with a resorbable collagen membrane. Implants were placed 9 and 6 months after the sinus lift in Patient 1 and Patient 2, respectively.In both cases, substantial radiographic bone fill of the oroantral bony defect was achieved allowing successful placement of dental implants. Following insertion of final restorations, the patients were satisfied with the esthetic outcomes and reported improved oral function.Vertical sinus elevation through residual bony oroantral defects in conjunction with placement of bone allograft mixed with PRF yields sufficient alveolar bone for subsequent placement of dental implants.Bone defects secondary to oroantral communications resulting from dental extractions may persist despite successful soft tissue closure. Such oroantral communication (OAC) pose challenges for dental implant placement. This report describes a technique for repairing oroantral bony defects and subsequent placement of dental implants. Two patients presented with OACs in the first maxillary molar region. Vertical sinus elevation with corticocancellous bone allograft and platelet-rich fibrin, was achieved through the existing defect. Substantial radiographic bone fill of the oroantral bony defect was achieved and implants with final restorati[cell cut: 2378 characters, first 2000 kept]
rights: © 2025 The Author(s). Clinical Advances in Periodontics published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.
doi: 10.1002/cap.10332
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yang M
      type: Person
      first name: Min
      last name: Yang
      member of: Department of Periodontics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  slot:
    index: 2
    item: Ting M
      type: Person
      first name: Miriam
      last name: Ting
      member of: Department of Periodontics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  slot:
    index: 3
    item: Neiva R
      type: Person
      first name: Rodrigo
      last name: Neiva
      member of: Department of Periodontics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  slot:
    index: 4
    item: Korostoff J
      type: Person
      first name: Jonathan
      last name: Korostoff
      member of: Department of Periodontics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:43
e ISSN: 2163-0097
has issn l: 2163-0097
has NLM journal title abbreviation: Clin Adv Periodontics
publication name: Clinical advances in periodontics
language: eng
has national library of medicine journal id: 101597440
derived from: NLM
has place of publication: United States
source: Clin Adv Periodontics. 2025-02-14;():.

Sex Differences in the Relationship Between Lipid Ratios and the Risk of Carotid Plaque.
pmid: 39949279
abstract: Lipid ratio is a balance between atherogenesis and antiatherogenesis. it is an important predictive marker of carotid plaque. The lipid ratios, which include non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C), remnant cholesterol (RC)/HDL-C, apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1), low-density lipoprotein cholesterol (LDL-C)/HDL-C, ApoB/HDL-C, total cholesterol (TC)/HDL-C, triglycerides (TG)/HDL-C, were included and analyzed. Sex differences in the relationship between lipid ratios and carotid plaque were discussed. The risk of carotid plaque was found to be significantly associated with the Non-HDL-C /HDL-C, RC/HDL-C, ApoB/ApoA1, LDL-C /HDL-C, ApoB/HDL-C, TC/HDL-C in females but not in males. The ApoB/HDL risk presented the highest relationship with carotid plaque in females only. The predictive value of the aforementioned lipid ratios for carotid plaque was observed in females only.
doi: 10.1177/00033197251316624
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Wang LL
      type: Person
      first name: Ling-Ling
      last name: Wang
      member of: Stroke Center, Department of Neurology, the Affiliated Hospital of Beihua University, Jilin, China.
  slot:
    index: 2
    item: Xu ZX
      type: Person
      first name: Zi-Xiang
      last name: Xu
      member of: Pathology Department, Jilin Cancer Hospital, Changchun, Jilin, China.
  slot:
    index: 3
    item: Sun BQ
      type: Person
      first name: Bo-Qian
      last name: Sun
      member of: Stroke Center, Department of Neurology, the Affiliated Hospital of Beihua University, Jilin, China.
  slot:
    index: 4
    item: Liu J
      type: Person
      first name: Jie
      last name: Liu
      member of: Endoscopy Department, Jilin Cancer Hospital, Changchun, Jilin, China.
  slot:
    index: 5
    item: Liu XL
      type: Person
      first name: Xue-Lian
      last name: Liu
      member of: Department of Hematology, The First Hospital of Jilin University, Changchun, Jilin, China.
  slot:
    index: 6
    item: Liu D
      type: Person
      first name: Dong
      last name: Liu
      member of: Emergency Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:43
e ISSN: 1940-1574
has issn l: 0003-3197
has NLM journal title abbreviation: Angiology
publication name: Angiology
language: eng
has national library of medicine journal id: 0203706
derived from: NLM
pg: 33197251316624
has place of publication: United States
source: Angiology. 2025-02-14;():33197251316624.

Excellent long-term device survival of inflatable penile prosthesis over 27 years.
pmid: 39949289
abstract: The study aimed to assess the long-term device survival of a 3-piece inflatable penile prosthesis (PP) in patients with erectile dysfunction (ED). This retrospective observational longitudinal study involved patients with drug-refractory ED who underwent primary 3-piece inflatable PP implantation at a single center from 1992 to 2019. The outcomes included complications of various inflatable PP models, and Kaplan-Meier analysis was used to estimate the probability of PP survival. Of the total 426 patients, 140 (32.9%) were implanted in the period of 1992-2000, 128 (30.0%) in the period of 2001-2008, and 158 (37.1%) in the period of 2009-2019. The PP used in the study included AMS 700 CX (62.0%, n = 264), AMS 700 CXR (7.7%, n = 33), AMS Ultrex Plus (10.3%, n = 44), and Alpha I (20.0%, n = 85). The overall complication rate was 28.2% (120/426), and the majority happened after 6 months. The causes of device removal included mechanical failure (11.0%, n = 47), infection (3.9%, n = 17), cylinder extrusion (6.3%, n = 27), and unspecified (0.2%, n = 1). Of the total mechanical failures (n = 47), 18 (38.3%) occurred in the cylinders, 10 (21.3%) occurred in the pump, 7 (14.9%) occurred in the reservoir, 6 (12.8%) occurred in the connections, and 6 (12.8%) were nonspecific. Global average survival rates of the PP at 1 year, 5 years, 10 years, and 15 years were 96.2%, 86.7%, 77.5%, and 58.7%, respectively. The 3-piece inflatable PP has an excellent device survival rate at 5 years and 10 years.
rights: Copyright ©The Author(s)(2025).
has PII: 00129336-990000000-00284
doi: 10.4103/aja2024112
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Moncada I
      type: Person
      first name: Ignacio
      last name: Moncada
      member of: Department of Urology and Robotic Surgery, La Zarzuela University Hospital, Madrid 28023, Spain.
  slot:
    index: 2
    item: Krishnappa P
      type: Person
      first name: Pramod
      last name: Krishnappa
      member of: Department of Urology and Robotic Surgery, La Zarzuela University Hospital, Madrid 28023, Spain.Andrology Division, Department of Urology and Robotic Surgery, AndroNeo, Orchidz Health, NU Hospitals, Bengaluru 560010, Karnataka, India.
  slot:
    index: 3
    item: Martinez-Salamanca JI
      type: Person
      first name: Juan Ignacio
      last name: Martinez-Salamanca
      member of: Lyx Institute of Urology, Francisco de Vitoria University, Madrid 28006, Spain.Department of Urology, Puerta De Hierro-Majadahonda University Hospital, Madrid 28222, Spain.
  slot:
    index: 4
    item: Palma-Hendges LP
      type: Person
      first name: Luiz Pedro
      last name: Palma-Hendges
      member of: Lyx Institute of Urology, Francisco de Vitoria University, Madrid 28006, Spain.
  slot:
    index: 5
    item: Gonzalez-Garcia FJ
      type: Person
      first name: Francisco Javier
      last name: Gonzalez-Garcia
      member of: Lyx Institute of Urology, Francisco de Vitoria University, Madrid 28006, Spain.
  slot:
    index: 6
    item: Hernandez-Fernandez C
      type: Person
      first name: Carlos
      last name: Hernandez-Fernandez
      member of: Department of Urology, Gregorio Maranon University General Hospital, Complutense University, Madrid 28007, Spain.
  slot:
    index: 7
    item: Lledo-Garcia E
      type: Person
      first name: Enrique
      last name: Lledo-Garcia
      member of: Department of Urology, Gregorio Maranon University General Hospital, Complutense University, Madrid 28007, Spain.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:43
e ISSN: 1745-7262
has issn l: 1008-682X
has NLM journal title abbreviation: Asian J Androl
publication name: Asian journal of andrology
language: eng
has national library of medicine journal id: 100942132
derived from: NLM
has place of publication: China
source: Asian J Androl. 2025-02-14;():.

Hetero-Diels-Alder reactions of (isobenzo)furans.
pmid: 39949284
abstract: Hetero-Diels-Alder reactions of furans and isobenzofurans provide convergent redox-neutral access to hetero-oxanorbornene derivatives. These versatile intermediates serve as precursors to a variety of heterocycles, polymers, and complex natural products. Herein we comprehensively review this area of research and speculate on what developments are required to advance the field.
doi: 10.1039/d5ob00050e
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: DeAngelis CJ
      type: Person
      first name: Christopher J
      last name: DeAngelis
      member of: Department of Chemistry, University of Georgia, 302 East Campus Road, Athens, GA, 30602, USA. chirs.newton@uga.edu.
  slot:
    index: 2
    item: Newton CG
      type: Person
      first name: Christopher G
      last name: Newton
      member of: Department of Chemistry, University of Georgia, 302 East Campus Road, Athens, GA, 30602, USA. chirs.newton@uga.edu.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:43
e ISSN: 1477-0539
has issn l: 1477-0520
has NLM journal title abbreviation: Org Biomol Chem
publication name: Organic & biomolecular chemistry
language: eng
has national library of medicine journal id: 101154995
derived from: NLM
has place of publication: England
source: Org Biomol Chem. 2025-02-14;():.

10-year follow-up of adolescent leukemia diagnosed through gingiva: A case report.
pmid: 39949297
abstract: Systemic diseases often present initial signs through oral manifestations, making early recognition essential for accurate diagnosis and effective treatment planning. Patients with acute lymphoblastic leukemia (ALL) commonly experience gingival issues. This case report discusses the treatment and outcomes of a 12-year-old female patient who presented with gingival swelling and pain and was subsequently diagnosed with ALL.The patient underwent chemotherapy and basic periodontal supragingival scaling. Comprehensive clinical assessments, oral photographs, and imaging data were recorded at the initial visit, and at follow-ups 8 years and 10 years later.A routine blood test and bone marrow aspiration confirmed a diagnosis of B-cell acute lymphoblastic leukemia (B-cell ALL). After 1 year of chemotherapy with rituximab, the patient recovered and was discharged. An 8-year follow-up revealed significant clinical attachment gain and healthy gingival status, and complete recovery was observed at a 10-year follow-up.Adolescents presenting with swollen and bleeding gums should be evaluated for potential leukemia. Dentists, especially periodontists, should be aware of the oral manifestations of ALL and coordinate with medical professionals to establish a comprehensive, long-term treatment plan. Periodontal health in adolescents with ALL can improve significantly with leukemia remission and appropriate basic periodontal therapy.Oral manifestations as early indicators: In adolescents with acute lymphoblastic leukemia (ALL), systemic symptoms may be minimal or absent. Early recognition of oral changes, such as gingival swelling or bleeding, is crucial for timely diagnosis. Long-term periodontal recovery: A 10-year follow-up indicates that periodontal health can improve following leukemia treatment and basic periodontal therapy, although longer follow-up is recommended to assess the stability of recovery.It is challenging to recognize systemic diseases early through oral manifestatio[cell cut: 2768 characters, first 2000 kept]
rights: © 2025 American Academy of Periodontology.
doi: 10.1002/cap.10340
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yang G
      type: Person
      first name: Gang
      last name: Yang
      member of: Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
  slot:
    index: 2
    item: Tu Y
      type: Person
      first name: Yuan
      last name: Tu
      member of: Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
  slot:
    index: 3
    item: Hu W
      type: Person
      first name: Wenjie
      last name: Hu
      member of: Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
  slot:
    index: 4
    item: Feng X
      type: Person
      first name: Xianghui
      last name: Feng
      member of: Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & Beijing Key Laboratory of Digital Stomatology, Beijing, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:53
e ISSN: 2163-0097
has issn l: 2163-0097
has NLM journal title abbreviation: Clin Adv Periodontics
publication name: Clinical advances in periodontics
language: eng
has national library of medicine journal id: 101597440
derived from: NLM
has place of publication: United States
source: Clin Adv Periodontics. 2025-02-14;():.

Serum Estradiol Concentrations With Estradiol 0.06% Gel in Transgender and Gender-Diverse Adults.
pmid: 39949293
abstract: Transgender and gender-diverse individuals undergoing estradiol therapy for gender affirmation are typically treated with oral or transdermal estradiol, with transdermal estradiol recommended for those aged > 45 years. There are limited data evaluating estradiol gel in gender-affirming hormone therapy regimens. We aimed to assess the serum estradiol concentrations achieved with estradiol 0.06% gel in transgender and gender-diverse adults.Retrospective cross-sectional audit of transgender and gender-diverse adults at endocrine clinics in Melbourne, Australia.Eighty-one adults treated with estradiol 0.06% gel.Outcomes were estradiol 0.06% gel dose, serum estradiol concentration and proportion of individuals achieving target serum estradiol concentrations in consensus guidelines.Median serum estradiol concentration was 396 pmol/L (233-681) on 1.5 mg (1.5-2.25) estradiol 0.06% gel daily. Forty-six percent of individuals achieved serum estradiol concentrations within target range (250-600 pmol/L) of Australian consensus guidelines; 27% were below range and 27% were above range. There was a weak positive correlation between estradiol gel dose and serum estradiol concentration (r = 0.23, p = 0.04).Estradiol 0.06% gel achieves target serum estradiol concentrations in a significant proportion of transgender and gender-diverse adults. This represents an alternative estradiol formulation for individuals desiring estradiol therapy for gender affirmation.
rights: © 2025 The Author(s). Clinical Endocrinology published by John Wiley & Sons Ltd.
doi: 10.1111/cen.15217
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Maggacis RA
      type: Person
      first name: Raquel A
      last name: Maggacis
      member of: Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
  slot:
    index: 2
    item: Cheung AS
      type: Person
      first name: Ada S
      last name: Cheung
      member of: Trans Health Research Group, Department of Medicine (Austin Health), University of Melbourne, Melbourne, Victoria, Australia.Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia.
  slot:
    index: 3
    item: Nolan BJ
      type: Person
      first name: Brendan J
      last name: Nolan
      member of: Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.Trans Health Research Group, Department of Medicine (Austin Health), University of Melbourne, Melbourne, Victoria, Australia.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:53
e ISSN: 1365-2265
has issn l: 0300-0664
has NLM journal title abbreviation: Clin Endocrinol (Oxf)
publication name: Clinical endocrinology
language: eng
has national library of medicine journal id: 0346653
derived from: NLM
has place of publication: England
source: Clin Endocrinol (Oxf). 2025-02-14;():.

Regulation and Clinical Application of Exosomes in Venous Thrombosis.
pmid: 39949294
abstract: Exosomes refer to a group of extracellular vesicles naturally released from mammalian cells with a diameter of 30-150 nm. Exosomes contain a variety of biologically active molecules, such as cytoplasmic proteins, chemokines, cytokines, and microRNA (miRNA). They are widely involved in intercellular communication and regulate the behavior of recipient cells. Venous thrombosis is a pathological change caused by vascular endothelial cell damage, hemodynamic changes, and the hypercoagulable state of blood. Exosomes from different cell sources are involved in the process of venous thrombosis. Exosomes can also be used as therapeutic carriers for tissue regeneration and drug delivery. Therefore, the study of exosomes is crucial for the formation, diagnosis, and treatment of venous thrombosis. In this review, we summarize the biological characteristics of exosomes and their mechanism of action in venous thrombosis. In addition, we also focused on its potential clinical applications, including as a diagnostic marker and therapeutic carrier for venous thrombosis.
doi: 10.1177/00033197251319597
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Shao F
      type: Person
      first name: Fei
      last name: Shao
      member of: School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.Department of Vascular Surgery, Affiliated Hospital of Jining Medical University, Jining, China.
  slot:
    index: 2
    item: He R
      type: Person
      first name: Ruchang
      last name: He
      member of: Department of Endocrinology, Genetics and Metabolism, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
  slot:
    index: 3
    item: Jin Y
      type: Person
      first name: Yang
      last name: Jin
      member of: Department of Radiotherapy, Jining First People's Hospital, Jining, China.
  slot:
    index: 4
    item: Pang Y
      type: Person
      first name: Yunfeng
      last name: Pang
      member of: School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.Department of Vascular Surgery, Affiliated Hospital of Jining Medical University, Jining, China.
  slot:
    index: 5
    item: Sun Z
      type: Person
      first name: Ziqiang
      last name: Sun
      member of: Department of Vascular Surgery, Affiliated Hospital of Jining Medical University, Jining, China.
  slot:
    index: 6
    item: Zhang B
      type: Person
      first name: Bin
      last name: Zhang
      member of: Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
  slot:
    index: 7
    item: Jin S
      type: Person
      first name: Song
      last name: Jin
      member of: Department of Vascular Surgery, Affiliated Hospital of Jining Medical University, Jining, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:53
e ISSN: 1940-1574
has issn l: 0003-3197
has NLM journal title abbreviation: Angiology
publication name: Angiology
language: eng
has national library of medicine journal id: 0203706
derived from: NLM
pg: 33197251319597
has place of publication: United States
source: Angiology. 2025-02-14;():33197251319597.

Identifying Behavioral Change Techniques and Mode of Delivery in Yoga Interventions Across Five Neurological Conditions: A Scoping Review.
pmid: 39949298
abstract: Objective: To identify behavior change techniques (BCTs) and the mode of delivery used in yoga interventions across five neurological conditions. Methods: This scoping review followed Arksey and O'Malley's methodological framework for conducting scoping reviews. Medline, CINAHL, EMBASE, PsycINFO, and CENTRAL databases were searched, combining key terms for population and intervention. Covidence software was used for study selection. Template for Intervention Description and Replication checklist was used to report the intervention and study quality was assessed using the Physiotherapy Evidence Database (PEDro) scale. Interventions were coded for BCTs using various taxonomies and delivery approaches were classified using Mode of Delivery Taxonomy Version 0. Result: Among 4805 articles screened, 35 met the inclusion criteria. Parkinson's disease, multiple sclerosis, and stroke were the most prevalent disability types with fewer studies on spinal cord injury and traumatic brain injury. A total of 134 BCTs were identified, 20 out of the 93 BCTs (25%) were from the BCT v1 taxonomy, while 15 additional BCTs were identified from other taxonomies and some BCTs were defined by the authors based on the need for yoga interventions. The most used BCTs included 12.6 body changes (68.57%, n = 24), 4.1 instruction (57.14%, n = 20), 12.5 adding objects (48.57%, n = 17), 1.2 problem solving (37.14%, n = 13), 6.1 demonstration (34.28%, n = 12), 8.1 behavioral practice and rehearsal (31.42%, n = 11), and 8.7 graded tasks (28.57%, n = 10). The most common delivery approach was face-to-face. The median PEDro score was 6 indicating medium study quality. Conclusion: Clear reporting of the intervention description and use of BCTs may enhance understanding and ability to replicate yoga interventions. This helps to adapt yoga by changing behaviors using specific BCTs to meet the goals and principles of yoga depending on the target population. The review may help inform future research to exa[cell cut: 2060 characters, first 2000 kept]
doi: 10.1089/jicm.2024.0536
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Prajapati H
      type: Person
      first name: Himani
      last name: Prajapati
      member of: Rehabilitation Science Program, University of British Columbia, Vancouver, Canada.Centre for Aging SMART, Rehabilitation Research Program, Vancouver, Canada.
  slot:
    index: 2
    item: Best KL
      type: Person
      first name: Krista L
      last name: Best
      member of: School of Rehabilitation Sciences, Faculty of Medicine, Université Laval, Quebec City, Canada.Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS), Quebec City, Canada.
  slot:
    index: 3
    item: Dhariwal A
      type: Person
      first name: Aditya
      last name: Dhariwal
      member of: Centre for Aging SMART, Rehabilitation Research Program, Vancouver, Canada.Department of Occupational Science & Occupational Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
  slot:
    index: 4
    item: Mortenson WB
      type: Person
      first name: W Ben
      last name: Mortenson
      member of: Rehabilitation Science Program, University of British Columbia, Vancouver, Canada.Centre for Aging SMART, Rehabilitation Research Program, Vancouver, Canada.Department of Occupational Science & Occupational Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.International Collaboration on Repair DiscoveriesVancouver, BC, Canada.
  slot:
    index: 5
    item: Miller WC
      type: Person
      first name: William C
      last name: Miller
      member of: Rehabilitation Science Program, University of British Columbia, Vancouver, Canada.Centre for Aging SMART, Rehabilitation Research Program, Vancouver, Canada.Department of Occupational Science & Occupational Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T03:53
e ISSN: 2768-3613
has issn l: 2768-3605
has NLM journal title abbreviation: J Integr Complement Med
publication name: Journal of integrative and complementary medicine
language: eng
has national library of medicine journal id: 9918283075806676
derived from: NLM
has place of publication: United States
source: J Integr Complement Med. 2025-02-14;():.

Antibiotic Consumption and Bloodstream Infections in Patients With Chronic-limb Threatening Ischemia Following Endovascular Therapy in East-west Germany, 2019-2020.
pmid: 39949310
abstract: Patients with chronic-limb threatening ischemia (CLTI) and peripheral wounds might be predisposed for systemic infections. The study aimed to describe the rate of systemic infections in patients with CLTI compared with peripheral artery obstructive disease (PAOD) patients without CLTI, both independently of endovascular treatment (EVT) and after EVT. Administrative data of the AOK Baden-Wuerttemberg (AOK BW) from patients with PAOD were analyzed considering bloodstream infection (BSI), 30-day readmission and prescribed antibiotics for ischemic ulcers. The risk of BSI increased 3.9-fold (95% CI: 3.4-4.4) in patients with PAOD Rutherford-Becker category (RBC) 5 and 6 (n = 11,741) compared with PAOD RBC 1-4 (n = 23,482; 6.81% vs 1.67%, P < .01). The risk of Staphylococcus aureus BSI increased 5.6-fold (95% CI: 4.1-7.7) comparing RBC 5 and 6 (1.2%) with RBC 1-4 (0.22%, P < .01). Outpatient antibiotic prescriptions were dominated by aminopenicillins with β-lactamase inhibitors, accounting for 34.9%. Clindamycin, cefuroxime, and fluoroquinolones represented 14.9%, 13.5%, and 12.6% of prescriptions, respectively. Infections were responsible for 7.7% of 30-day readmissions following EVT. Patients with CLTI are at risk of developing BSI, and specifically S. aureus BSI. Infection-related causes in 30-day readmissions following EVT are common. The high use of clindamycin and cefuroxime in outpatients is concerning.
doi: 10.1177/00033197251319600
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Salm J
      type: Person
      first name: Jonas
      last name: Salm
      member of: Department of Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, Medical Center -Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  slot:
    index: 2
    item: Hofbauer-Milan V
      type: Person
      first name: Valeska
      last name: Hofbauer-Milan
      member of: AOK Baden-Wuerttemberg, Department of Data Analytics and Data Science, Stuttgart, Germany.
  slot:
    index: 3
    item: Wüstholz E
      type: Person
      first name: Elisabeth
      last name: Wüstholz
      member of: AOK Baden-Wuerttemberg, Department of Data Analytics and Data Science, Stuttgart, Germany.
  slot:
    index: 4
    item: Schneider O
      type: Person
      first name: Olaf
      last name: Schneider
      member of: AOK Baden-Wuerttemberg, Department of Data Analytics and Data Science, Stuttgart, Germany.
  slot:
    index: 5
    item: Westermann D
      type: Person
      first name: Dirk
      last name: Westermann
      member of: Department of Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, Medical Center -Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  slot:
    index: 6
    item: Zeller T
      type: Person
      first name: Thomas
      last name: Zeller
      member of: Department of Cardiology and Angiology, University Heart Center Freiburg - Bad Krozingen, Medical Center -Faculty of Medicine, University of Freiburg, Freiburg, Germany.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:03
e ISSN: 1940-1574
has issn l: 0003-3197
has NLM journal title abbreviation: Angiology
publication name: Angiology
language: eng
has national library of medicine journal id: 0203706
derived from: NLM
pg: 33197251319600
has place of publication: United States
source: Angiology. 2025-02-14;():33197251319600.

Letter: Confounding Factors in the Association Between Sarcopenia and Carotid Atherosclerosis Among Patients With Type 2 Diabetes Mellitus.
pmid: 39949309
doi: 10.1177/00033197251321262
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Petrovic J
      type: Person
      first name: Jelena
      last name: Petrovic
      member of: Clinic for Cardiology, University Clinical Center of Serbia, Belgrade, Serbia.
  slot:
    index: 2
    item: Şener YZ
      type: Person
      first name: Yusuf Ziya
      last name: Şener
      member of: Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:03
e ISSN: 1940-1574
has issn l: 0003-3197
has NLM journal title abbreviation: Angiology
publication name: Angiology
language: eng
has national library of medicine journal id: 0203706
derived from: NLM
pg: 33197251321262
has place of publication: United States
source: Angiology. 2025-02-14;():33197251321262.

Editorial: evaluating simple clinical tools for aortic disease prediction.
pmid: 39949327
doi: 10.1080/00015385.2024.2445342
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Zygouri A
      type: Person
      first name: Andromahi
      last name: Zygouri
      member of: CHU-Rennes - Cardiology, Université de Rennes - LTSI - INSERM, France.
  slot:
    index: 2
    item: Donal E
      type: Person
      first name: Erwan
      last name: Donal
      member of: CHU-Rennes - Cardiology, Université de Rennes - LTSI - INSERM, France.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:14
e ISSN: 1784-973X
has issn l: 0001-5385
has NLM journal title abbreviation: Acta Cardiol
publication name: Acta cardiologica
language: eng
has national library of medicine journal id: 0370570
derived from: NLM
starting page: 1
ending page: 2
has place of publication: England
source: Acta Cardiol. 2025-02-14;():1-2.

MLH1 and MSH2 expression in endometrial cancer - microscopic and computer assessment of immunohistochemical method.
pmid: 39949324
abstract: We aimed to compare MLH1 and MSH2 protein expression and Mismatch repair (MMR) status with clinical data: diagnosis, grading, and staging. Moreover, we wanted to assess any correlation between two immunohistochemical assessments: classic microscopic and computer analysis performed by a calibrated program.Our studies were conducted on 95 cases of endometrial cancer. For each, we performed H+E staining and immunohistochemistry (IHC) of two MMR status proteins: MLH1 and MSH2. Two independent researchers assessed IHC on a 0 to ++++ scale. We classified cases as MMR-deficient based on the microscopic assessment of the absence of expression of at least one protein. For computer analysis, we used Olympus cellSens software to measure the positive IHC reaction area in µm2 in five fields of vision.Despite using two different assessment methods, we did not identify any statistically significant relationship between diagnosis, grading, staging, MMR protein expression, and MMR status. However, we found a strong correlation between computer analysis and semi-quantitative microscopic assessment (r=0.59 for MLH1 and r=0.76 for MSH2; p<0.001 for both). Furthermore, we revealed that computer measurement of the expression area could be a good objective prediction test for microscopic analysis (p<0.001).We did not find a relationship between MMR status and grading, staging, or diagnosis. However, we present a novel approach to immunohistochemical assessment using computer analysis. It allows us to carry out more objective and accurate studies with the IHC method.
rights: ©The Author(s) 2025. Open Access. This article is licensed under a Creative Commons CC-BY International License.
has PII: HH-18-884
doi: 10.14670/HH-18-884
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Rogaliński J
      type: Person
      first name: Jan
      last name: Rogaliński
      member of: Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland. jrogalinski@ump.edu.pl.
  slot:
    index: 2
    item: Przewoźny S
      type: Person
      first name: Stanisław
      last name: Przewoźny
      member of: Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland.
  slot:
    index: 3
    item: de Mezer M
      type: Person
      first name: Mateusz
      last name: de Mezer
      member of: Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland.
  slot:
    index: 4
    item: Markowska A
      type: Person
      first name: Anna
      last name: Markowska
      member of: Department of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.
  slot:
    index: 5
    item: Markowska J
      type: Person
      first name: Janina
      last name: Markowska
      member of: Gynecological Center, Poznanska, Poznan, Poland.
  slot:
    index: 6
    item: Żurawski J
      type: Person
      first name: Jakub
      last name: Żurawski
      member of: Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-06
dp: 2025 Feb 06
created: 2025-2-14T04:14
e ISSN: 1699-5848
has issn l: 0213-3911
has NLM journal title abbreviation: Histol Histopathol
publication name: Histology and histopathology
language: eng
has national library of medicine journal id: 8609357
derived from: NLM
pg: 18884
has place of publication: Spain
source: Histol Histopathol. 2025-02-06;():18884.

Editorial: New concepts and techniques to treat peri-trochanteric fracture.
pmid: 39949348
doi: 10.3389/fsurg.2024.1545562
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Fan J
      type: Person
      first name: Jixing
      last name: Fan
      member of: Department of Orthopedics, Peking University Third Hospital, Beijing, China.Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, China.
  slot:
    index: 2
    item: Lv Y
      type: Person
      first name: Yang
      last name: Lv
      member of: Department of Orthopedics, Peking University Third Hospital, Beijing, China.Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2024
dp: 2024
created: 2025-2-14T04:15
ISSN: 2296-875X
has issn l: 2296-875X
has NLM journal title abbreviation: Front Surg
publication name: Frontiers in surgery
language: eng
has national library of medicine journal id: 101645127
derived from: NLM
pg: 1545562
has place of publication: Switzerland
source: Front Surg. 2024;11():1545562.
volume: 11

Maximising the wrench capability of mobile manipulators with experiments on a UVMS.
pmid: 39949521
abstract: This paper presents methods for finding optimal configurations and actuator forces/torques to maximise contact wrenches in a desired direction for underwater vehicle manipulator systems (UVMS). The wrench maximisation problem is formulated as a bi-level optimisation problem, with upper-level variables in a low-dimensional parameterised redundancy space, and a linear lower-level problem. We additionally consider the cases of one or more manipulators with multiple contact forces, maximising the wrench capability while tracking a trajectory and generating large wrench impulses using dynamic motions. The specific cases of maximising force to lift a heavy load and maximising torque during a valve-turning operation are considered. Extensive experimental results are presented using a 6 degree of freedom (DOF) underwater robotic platform equipped with a 4DOF manipulator and show significant increases in the wrench capability compared to existing methods for mobile manipulators.
rights: Copyright © 2025 Marais, Pizarro and Williams.
has PII: 1442813
doi: 10.3389/frobt.2024.1442813
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Marais WJ
      type: Person
      first name: Wilhelm J
      last name: Marais
      member of: Australian Centre For Robotics (ACFR), University of Sydney, Sydney, NSW, Australia.
  slot:
    index: 2
    item: Pizarro O
      type: Person
      first name: Oscar
      last name: Pizarro
      member of: Department of Marine Technology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
  slot:
    index: 3
    item: Williams SB
      type: Person
      first name: Stefan B
      last name: Williams
      member of: Australian Centre For Robotics (ACFR), University of Sydney, Sydney, NSW, Australia.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2024
dp: 2024
created: 2025-2-14T04:18
e ISSN: 2296-9144
has issn l: 2296-9144
has NLM journal title abbreviation: Front Robot AI
publication name: Frontiers in robotics and AI
language: eng
has national library of medicine journal id: 101749350
derived from: NLM
pg: 1442813
has place of publication: Switzerland
source: Front Robot AI. 2024;11():1442813.
volume: 11

Toward Continued Growth for the JMI Community.
pmid: 39949517
abstract: JMI Editor in Chief Bennett Landman provides an overview of JMI Volume 12 Issue 1 and spotlights key aspects of JMI peer review, with an eye toward continued growth for the JMI community.
rights: © 2025 Society of Photo-Optical Instrumentation Engineers (SPIE).
has PII: 25-0205
doi: 10.1117/1.JMI.12.1.010101
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01
dp: 2025 Jan
created: 2025-2-14T04:18
ISSN: 2329-4302
has issn l: 2329-4302
issue: 1
has NLM journal title abbreviation: J Med Imaging (Bellingham)
publication name: Journal of medical imaging (Bellingham, Wash.)
language: eng
has national library of medicine journal id: 101643461
derived from: NLM
pg: 010101
has place of publication: United States
source: J Med Imaging (Bellingham). 2025-01;12(1):010101.
volume: 12

Corrigendum: Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson's disease: a crossover self-controlled fMRI study.
pmid: 39949538
abstract: [This corrects the article DOI: 10.3389/fnagi.2024.1444703.].
rights: Copyright © 2025 Fu, Hou, Zheng, Zhang, Gao, Yan, Ye and Liu.
doi: 10.3389/fnagi.2025.1560826
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Fu C
      type: Person
      first name: Chengwei
      last name: Fu
      member of: Department of Acupuncture, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.Department of Acupuncture, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, China.Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 2
    item: Hou X
      type: Person
      first name: Xiaoyan
      last name: Hou
      member of: Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 3
    item: Zheng C
      type: Person
      first name: Chunye
      last name: Zheng
      member of: Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 4
    item: Zhang Y
      type: Person
      first name: Yue
      last name: Zhang
      member of: Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 5
    item: Gao Z
      type: Person
      first name: Zhijie
      last name: Gao
      member of: Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.The Second Clinical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 6
    item: Yan Z
      type: Person
      first name: Zhaoxian
      last name: Yan
      member of: Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 7
    item: Ye Y
      type: Person
      first name: Yongsong
      last name: Ye
      member of: Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  slot:
    index: 8
    item: Liu B
      type: Person
      first name: Bo
      last name: Liu
      member of: Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:19
ISSN: 1663-4365
has issn l: 1663-4365
has NLM journal title abbreviation: Front Aging Neurosci
publication name: Frontiers in aging neuroscience
language: eng
has national library of medicine journal id: 101525824
derived from: NLM
pg: 1560826
has place of publication: Switzerland
source: Front Aging Neurosci. 2025;17():1560826.
volume: 17

Erratum: Global, regional, and national burden of diet high in processed meat from 1990 to 2019: a systematic analysis from the global burden of disease study 2019.
pmid: 39949548
abstract: [This corrects the article DOI: 10.3389/fnut.2024.1354287.].
rights: Copyright © 2025 Frontiers Production Office.
doi: 10.3389/fnut.2025.1563555
creator: Frontiers Production Office
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:19
ISSN: 2296-861X
has issn l: 2296-861X
has NLM journal title abbreviation: Front Nutr
publication name: Frontiers in nutrition
language: eng
has national library of medicine journal id: 101642264
derived from: NLM
pg: 1563555
has place of publication: Switzerland
source: Front Nutr. 2025;12():1563555.
volume: 12

Erratum: LncRNA CCND2-AS1 is up-regulated and regulates proliferation, migration, and invasion in breast cancer.
pmid: 39949597
abstract: [This corrects the article on p. 1453 in vol. 11, PMID: 31938243.].
rights: IJCEP Copyright © 2025.
doi: 10.62347/FOCJ5790
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Chen C
      type: Person
      first name: Chengze
      last name: Chen
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 2
    item: Xia E
      type: Person
      first name: Erjie
      last name: Xia
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 3
    item: Bhandari A
      type: Person
      first name: Adheesh
      last name: Bhandari
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 4
    item: Wang Y
      type: Person
      first name: Yinghao
      last name: Wang
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 5
    item: Shen Y
      type: Person
      first name: Yanyan
      last name: Shen
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 6
    item: Sindan N
      type: Person
      first name: Namita
      last name: Sindan
      member of: Department of Reproductive Health Center, The Second Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 7
    item: Lin Y
      type: Person
      first name: Yuehlung
      last name: Lin
      member of: Mathematical Sciences, University of Nottingham Ningbo, Zhejiang, PR China.
  slot:
    index: 8
    item: Wang X
      type: Person
      first name: Xiaoshang
      last name: Wang
      member of: School of International Studies, Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 9
    item: Yang F
      type: Person
      first name: Fan
      last name: Yang
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
  slot:
    index: 10
    item: Wang O
      type: Person
      first name: Ouchen
      last name: Wang
      member of: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:20
e ISSN: 1936-2625
has issn l: 1936-2625
issue: 1
has NLM journal title abbreviation: Int J Clin Exp Pathol
publication name: International journal of clinical and experimental pathology
language: eng
has national library of medicine journal id: 101480565
derived from: NLM
starting page: 44
ending page: 45
has place of publication: United States
source: Int J Clin Exp Pathol. 2025;18(1):44-45.
volume: 18

Erratum: Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo.
pmid: 39949596
abstract: [This corrects the article on p. 2818 in vol. 7, PMID: 25031701.].
rights: IJCEP Copyright © 2025.
doi: 10.62347/UEHK2077
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lv ZD
      type: Person
      first name: Zhi-Dong
      last name: Lv
      member of: Department of Breast Surgery, The Affiliated Hospital of Medical College, Qingdao University Qingdao 266003, Shandong, P. R. China.
  slot:
    index: 2
    item: Liu XP
      type: Person
      first name: Xiang-Ping
      last name: Liu
      member of: Central Laboratory of Molecular Biology, The Affiliated Hospital of Medical College, Qingdao University Qingdao 266003, Shandong, P. R. China.
  slot:
    index: 3
    item: Zhao WJ
      type: Person
      first name: Wei-Jun
      last name: Zhao
      member of: Department of General Surgery, The Affiliated Hospital of Chifeng University Chifeng 024000, Inner Mongolia, P. R. China.
  slot:
    index: 4
    item: Dong Q
      type: Person
      first name: Qian
      last name: Dong
      member of: Department of Pediatric Surgery, The Affiliated Hospital of Medical College, Qingdao University Qingdao 266003, Shandong, P. R. China.
  slot:
    index: 5
    item: Li FN
      type: Person
      first name: Fu-Nian
      last name: Li
      member of: Department of Breast Surgery, The Affiliated Hospital of Medical College, Qingdao University Qingdao 266003, Shandong, P. R. China.
  slot:
    index: 6
    item: Wang HB
      type: Person
      first name: Hai-Bo
      last name: Wang
      member of: Department of Breast Surgery, The Affiliated Hospital of Medical College, Qingdao University Qingdao 266003, Shandong, P. R. China.
  slot:
    index: 7
    item: Kong B
      type: Person
      first name: Bin
      last name: Kong
      member of: Department of Breast Surgery, The Affiliated Hospital of Medical College, Qingdao University Qingdao 266003, Shandong, P. R. China.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:20
e ISSN: 1936-2625
has issn l: 1936-2625
issue: 1
has NLM journal title abbreviation: Int J Clin Exp Pathol
publication name: International journal of clinical and experimental pathology
language: eng
has national library of medicine journal id: 101480565
derived from: NLM
starting page: 42
ending page: 43
has place of publication: United States
source: Int J Clin Exp Pathol. 2025;18(1):42-43.
volume: 18

The Enigmatic 'Swiss Cheese' in macroscopic tissue pathology.
pmid: 39949673
has PII: JOMFP-28-547
doi: 10.4103/jomfp.jomfp_333_24
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Bavle RM
      type: Person
      first name: Radhika M
      last name: Bavle
      member of: Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, India.
created: 2025-2-14T10:57
date last updated: 2025-02-14
created: 2025-2-14T04:21
ISSN: 0973-029X
has issn l: 0973-029X
issue: 4
has NLM journal title abbreviation: J Oral Maxillofac Pathol
publication name: Journal of oral and maxillofacial pathology : JOMFP
language: eng
has national library of medicine journal id: 101227995
derived from: NLM
starting page: 547
ending page: 548
has place of publication: India
source: J Oral Maxillofac Pathol. ;28(4):547-548.
volume: 28

Correction to: Dynamics of Persistent Submicroscopic and Microscopic Plasmodium falciparum in Pregnant Women Under Intermittent Preventive Treatment: A Study Cohort in Benin.
pmid: 39949706
abstract: [This corrects the article DOI: 10.1093/ofid/ofae762.].
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
has PII: ofaf071
doi: 10.1093/ofid/ofaf071
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T04:22
ISSN: 2328-8957
has issn l: 2328-8957
issue: 2
has NLM journal title abbreviation: Open Forum Infect Dis
publication name: Open forum infectious diseases
language: eng
has national library of medicine journal id: 101637045
derived from: NLM
pg: ofaf071
has place of publication: United States
source: Open Forum Infect Dis. 2025-02;12(2):ofaf071.
volume: 12

Transplant Trial Watch.
pmid: 39949722
has PII: 14323
doi: 10.3389/ti.2025.14323
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: O'Callaghan JM
      type: Person
      first name: John M
      last name: O'Callaghan
      member of: Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.University Hospitals Coventry & Warwickshire, Coventry, United Kingdom.
  slot:
    index: 2
    item: Knight SR
      type: Person
      first name: Simon R
      last name: Knight
      member of: Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.Oxford Transplant Centre, Churchill Hospital, Oxford, United Kingdom.
created: 2025-2-14T10:57
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:22
e ISSN: 1432-2277
has issn l: 0934-0874
has NLM journal title abbreviation: Transpl Int
publication name: Transplant international : official journal of the European Society for Organ Transplantation
language: eng
has national library of medicine journal id: 8908516
derived from: NLM
pg: 14323
has place of publication: Switzerland
source: Transpl Int. 2025;38():14323.
volume: 38

Corrigendum: Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients.
pmid: 39949763
abstract: [This corrects the article DOI: 10.3389/fimmu.2024.1465448.].
rights: Copyright © 2025 Cumming, Addicott, Maruri, Pillay, Asmal, Moodley, Barreto-Durate, Araújo-Pereira, Mazibuko, Mhlane, Mbatha, Khan, Makhari, Karim, Peetluk, Pym, Moosa, van der Heijden, Sterling, Andrade, Leslie and Steyn.
doi: 10.3389/fimmu.2025.1557327
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Cumming BM
      type: Person
      first name: Bridgette M
      last name: Cumming
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 2
    item: Addicott KW
      type: Person
      first name: Kelvin W
      last name: Addicott
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 3
    item: Maruri F
      type: Person
      first name: Fernanda
      last name: Maruri
      member of: Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, United States.Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
  slot:
    index: 4
    item: Pillay V
      type: Person
      first name: Vanessa
      last name: Pillay
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 5
    item: Asmal R
      type: Person
      first name: Rukaya
      last name: Asmal
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 6
    item: Moodley S
      type: Person
      first name: Sashen
      last name: Moodley
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 7
    item: Barreto-Durate B
      type: Person
      first name: Beatriz
      last name: Barreto-Durate
      member of: Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.
  slot:
    index: 8
    item: Araújo-Pereira M
      type: Person
      first name: Mariana
      last name: Araújo-Pereira
      member of: Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.
  slot:
    index: 9
    item: Mazibuko M
      type: Person
      first name: Matilda
      last name: Mazibuko
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 10
    item: Mhlane Z
      type: Person
      first name: Zoey
      last name: Mhlane
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 11
    item: Mbatha N
      type: Person
      first name: Nikiwe
      last name: Mbatha
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 12
    item: Khan K
      type: Person
      first name: Khadija
      last name: Khan
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 13
    item: Makhari S
      type: Person
      first name: Senamile
      last name: Makhari
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 14
    item: Karim F
      type: Person
      first name: Farina
      last name: Karim
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 15
    item: Peetluk L
      type: Person
      first name: Lauren
      last name: Peetluk
      member of: Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, United States.
  slot:
    index: 16
    item: Pym AS
      type: Person
      first name: Alexander S
      last name: Pym
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 17
    item: Moosa MYS
      type: Person
      first name: Mahomed Yunus S
      last name: Moosa
      member of: Department of Infectious Diseases, University of KwaZulu-Natal, Durban, South Africa.
  slot:
    index: 18
    item: van der Heijden YF
      type: Person
      first name: Yuri F
      last name: van der Heijden
      member of: Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, United States.Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.Global Division, The Aurum Institute, Johannesburg, South Africa.
  slot:
    index: 19
    item: Sterling TS
      type: Person
      first name: Timothy S
      last name: Sterling
      member of: Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, United States.Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
  slot:
    index: 20
    item: Andrade BB
      type: Person
      first name: Bruno B
      last name: Andrade
      member of: Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.
  slot:
    index: 21
    item: Leslie A
      type: Person
      first name: Alasdair
      last name: Leslie
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.Department of Infectious Diseases, University of KwaZulu-Natal, Durban, South Africa.Department of Infection and Immunity, University College of London, London, United Kingdom.
  slot:
    index: 22
    item: Steyn AJC
      type: Person
      first name: Adrie J C
      last name: Steyn
      member of: Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.Centers for AIDS Research and Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:23
e ISSN: 1664-3224
has issn l: 1664-3224
has NLM journal title abbreviation: Front Immunol
publication name: Frontiers in immunology
language: eng
has national library of medicine journal id: 101560960
derived from: NLM
pg: 1557327
has place of publication: Switzerland
source: Front Immunol. 2025;16():1557327.
volume: 16

Corrigendum: Mathematical modeling in autoimmune diseases: from theory to clinical application.
pmid: 39949766
abstract: [This corrects the article DOI: 10.3389/fimmu.2024.1371620.].
rights: Copyright © 2025 Ugolkov, Nikitich, Leon, Helmlinger, Peskov, Sokolov and Volkova.
doi: 10.3389/fimmu.2025.1557929
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ugolkov Y
      type: Person
      first name: Yaroslav
      last name: Ugolkov
      member of: Research Center of Model-Informed Drug Development, Ivan Mikhaylovich (I.M.) Sechenov First Moscow State Medical University, Moscow, Russia.Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences (RAS), Moscow, Russia.Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
  slot:
    index: 2
    item: Nikitich A
      type: Person
      first name: Antonina
      last name: Nikitich
      member of: Research Center of Model-Informed Drug Development, Ivan Mikhaylovich (I.M.) Sechenov First Moscow State Medical University, Moscow, Russia.Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences (RAS), Moscow, Russia.
  slot:
    index: 3
    item: Leon C
      type: Person
      first name: Cristina
      last name: Leon
      member of: Modeling and Simulation Decisions FZ - LLC, Dubai, United Arab Emirates.
  slot:
    index: 4
    item: Helmlinger G
      type: Person
      first name: Gabriel
      last name: Helmlinger
      member of: Biorchestra Co., Ltd., Cambridge, MA, United States.
  slot:
    index: 5
    item: Peskov K
      type: Person
      first name: Kirill
      last name: Peskov
      member of: Research Center of Model-Informed Drug Development, Ivan Mikhaylovich (I.M.) Sechenov First Moscow State Medical University, Moscow, Russia.Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences (RAS), Moscow, Russia.Modeling and Simulation Decisions FZ - LLC, Dubai, United Arab Emirates.Sirius University of Science and Technology, Sirius, Russia.
  slot:
    index: 6
    item: Sokolov V
      type: Person
      first name: Victor
      last name: Sokolov
      member of: Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences (RAS), Moscow, Russia.Modeling and Simulation Decisions FZ - LLC, Dubai, United Arab Emirates.
  slot:
    index: 7
    item: Volkova A
      type: Person
      first name: Alina
      last name: Volkova
      member of: Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences (RAS), Moscow, Russia.Modeling and Simulation Decisions FZ - LLC, Dubai, United Arab Emirates.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:23
e ISSN: 1664-3224
has issn l: 1664-3224
has NLM journal title abbreviation: Front Immunol
publication name: Frontiers in immunology
language: eng
has national library of medicine journal id: 101560960
derived from: NLM
pg: 1557929
has place of publication: Switzerland
source: Front Immunol. 2025;16():1557929.
volume: 16

Exploitation potential and deep-rooted conformational relationships of traditional Chinese medicine polysaccharides.
pmid: 39949815
has PII: S1674-6384(24)00141-2
doi: 10.1016/j.chmed.2024.12.005
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Gao W
      type: Person
      first name: Wenyuan
      last name: Gao
      member of: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01
dp: 2025 Jan
created: 2025-2-14T04:23
e ISSN: 2589-3610
has issn l: 1674-6384
issue: 1
has NLM journal title abbreviation: Chin Herb Med
publication name: Chinese herbal medicines
language: eng
has national library of medicine journal id: 101556727
derived from: NLM
starting page: 1
ending page: 2
has place of publication: Singapore
source: Chin Herb Med. 2025-01;17(1):1-2.
volume: 17

Editorial: Host-diet-microbiome interactions in obesity prevention and treatment.
pmid: 39949868
doi: 10.3389/fnut.2024.1541977
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Barouei J
      type: Person
      first name: Javad
      last name: Barouei
      member of: Department of Agriculture, Nutrition and Human Ecology, Prairie View A&M University, Prairie View, TX, United States.Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX, United States.
  slot:
    index: 2
    item: Kable ME
      type: Person
      first name: Mary E
      last name: Kable
      member of: USDA-ARS Western Human Nutrition Research Center, Davis, CA, United States.
  slot:
    index: 3
    item: Moussavi M
      type: Person
      first name: Mahta
      last name: Moussavi
      member of: Cooperative Agricultural Research Center, Prairie View A&M University, Prairie View, TX, United States.Food Security Research Center, Prairie View A&M University, Prairie View, TX, United States.
  slot:
    index: 4
    item: Hsieh YH
      type: Person
      first name: Yu-Hsin
      last name: Hsieh
      member of: Division of Medicinal Products, Taiwan Food and Drug Administration, Taipei, Taiwan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2024
dp: 2024
created: 2025-2-14T04:24
ISSN: 2296-861X
has issn l: 2296-861X
has NLM journal title abbreviation: Front Nutr
publication name: Frontiers in nutrition
language: eng
has national library of medicine journal id: 101642264
derived from: NLM
pg: 1541977
has place of publication: Switzerland
source: Front Nutr. 2024;11():1541977.
volume: 11

miR-99b/let-7e/miR-125a cluster suppresses pancreatic cancer through regulation of NR6A1 [Retraction].
pmid: 39949946
abstract: [This retracts the article on p. 114 in vol. 14, PMID: 38323281.].
rights: AJCR Copyright © 2025.
doi: 10.62347/XUPJ2757
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:25
ISSN: 2156-6976
has issn l: 2156-6976
issue: 1
has NLM journal title abbreviation: Am J Cancer Res
publication name: American journal of cancer research
language: eng
has national library of medicine journal id: 101549944
derived from: NLM
pg: 406
has place of publication: United States
source: Am J Cancer Res. 2025;15(1):406.
volume: 15

Procedural justice and (in)equitable participation in climate negotiations.
pmid: 39949970
abstract: Formally, state parties are equal in all United Nations negotiations. In theory, every state, regardless of its size, economic or political power, has the same opportunities and rights to participate. Nevertheless, United Nations negotiations, such as those on climate, are often considered highly unequal in practice. Many states struggle to meaningfully engage in complex and highly technical multilateral negotiations, including because their delegations are smaller. Here we examine delegation size in United Nations climate negotiations through a procedural justice lens. Starting from normative principles of procedural justice, we argue that equitable negotiations demand the capability of all parties to send a sufficient number of delegates - around 15. Using descriptive analysis of data on delegation sizes of recent Conferences of the Parties, we then highlight that many parties in practice send smaller delegations. Based on these results, we suggest two routes for making climate negotiations more equitable: (i) providing additional resources to poor states to increase their delegation size; and (ii) trimming the overall negotiation agenda to lower the sufficiency threshold.
rights: © 2025 The Authors.
doi: 10.14324/111.444/ucloe.3116
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Klöck C
      type: Person
      first name: Carola
      last name: Klöck
      member of: Center for International Studies, Sciences Po, Paris, France.
  slot:
    index: 2
    item: Baatz C
      type: Person
      first name: Christian
      last name: Baatz
      member of: Department of Philosophy, Kiel University, Kiel, Germany.
  slot:
    index: 3
    item: Wendler N
      type: Person
      first name: Nils
      last name: Wendler
      member of: Department of Philosophy, Kiel University, Kiel, Germany.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:26
e ISSN: 2632-0886
has issn l: 2632-0886
has NLM journal title abbreviation: UCL Open Environ
publication name: UCL open. Environment
language: eng
has national library of medicine journal id: 101771734
derived from: NLM
pg: e3116
has place of publication: England
source: UCL Open Environ. 2025;7():e3116.
volume: 7

Requiring durations of therapy at the time of antibiotic order entry reduces antibiotic use.
pmid: 39950008
abstract: The impact of required durations of therapy for antibiotic orders at the time of order entry has not been reported. Requiring ordering clinicians to enter stop dates at the time of antibiotic order entry decreased DOT/1000 patient days for orders with empiric indication from 154 to 119 (-34.9 (-55.7 to -14)).
rights: © The Author(s) 2025.
has PII: S2732494X25000208
doi: 10.1017/ash.2025.20
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wright MR
      type: Person
      first name: Megan R
      last name: Wright
      member of: Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN, USA.
  slot:
    index: 2
    item: Gillon J
      type: Person
      first name: Jessica
      last name: Gillon
      member of: Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN, USA.
  slot:
    index: 3
    item: Katz SE
      type: Person
      first name: Sophie E
      last name: Katz
      member of: Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville TN, USA.
  slot:
    index: 4
    item: Banerjee R
      type: Person
      first name: Ritu
      last name: Banerjee
      member of: Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville TN, USA.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:26
e ISSN: 2732-494X
has issn l: 2732-494X
issue: 1
has NLM journal title abbreviation: Antimicrob Steward Healthc Epidemiol
publication name: Antimicrobial stewardship & healthcare epidemiology : ASHE
language: eng
has national library of medicine journal id: 9918266096106676
derived from: NLM
pg: e45
has place of publication: England
source: Antimicrob Steward Healthc Epidemiol. 2025;5(1):e45.
volume: 5

Estimation of the mean exponential survival time under a sequential censoring scheme.
pmid: 39950013
abstract: The exponential distribution can provide a simple and appealing survival-time model in reliability analysis and life tests. Due to certain experimental designs, time limitations, budgetary requirements, and other reasons, however, only censored data can be obtained. In this paper, we propose a novel estimation procedure for the mean survival time of an exponential distribution under a sequential censoring scheme, which can be treated as a combination of type I censoring and type II censoring. The procedure makes a trade-off between estimation error and sampling cost, using the minimum number of observations. An extensive set of Monte Carlo simulations is conducted to further validate its remarkable performance. To demonstrate the practical applicability, we then implement this newly proposed procedure to assess the reliability of various Backblaze's hard disk models.
rights: © 2024 Informa UK Limited, trading as Taylor & Francis Group.
has PII: 2386609
doi: 10.1080/02664763.2024.2386609
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Hu J
      type: Person
      first name: Jun
      last name: Hu
      member of: Department of Mathematics and Statistics, Oakland University, Rochester, MI, USA.
  slot:
    index: 2
    item: So HY
      type: Person
      first name: Hon Yiu
      last name: So
      member of: Department of Mathematics and Statistics, Oakland University, Rochester, MI, USA.
  slot:
    index: 3
    item: Zhuang Y
      type: Person
      first name: Yan
      last name: Zhuang
      member of: Mathematics and Statistics Department, Connecticut College, New London, CT, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:26
ISSN: 0266-4763
has issn l: 0266-4763
issue: 3
has NLM journal title abbreviation: J Appl Stat
publication name: Journal of applied statistics
language: eng
has national library of medicine journal id: 9883455
derived from: NLM
starting page: 669
ending page: 686
has place of publication: England
source: J Appl Stat. 2025;52(3):669-686.
volume: 52

Editorial: Inorganic chemistry, polymer chemistry, and solid state chemistry editor's pick 2024.
pmid: 39950134
has PII: 1562468
doi: 10.3389/fchem.2025.1562468
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Carlos LD
      type: Person
      first name: Luís D
      last name: Carlos
      member of: Physics Department and CICECO-Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal.
  slot:
    index: 2
    item: Musto P
      type: Person
      first name: Pellegrino
      last name: Musto
      member of: Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Pozzuoli, Italy.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025
dp: 2025
created: 2025-2-14T04:28
ISSN: 2296-2646
has issn l: 2296-2646
has NLM journal title abbreviation: Front Chem
publication name: Frontiers in chemistry
language: eng
has national library of medicine journal id: 101627988
derived from: NLM
pg: 1562468
has place of publication: Switzerland
source: Front Chem. 2025;13():1562468.
volume: 13

Further thoughts on a lower fibrinogen threshold prior to therapeutic plasma exchange.
pmid: 39950198
doi: 10.1111/trf.18111
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Urgun K
      type: Person
      first name: Kamran
      last name: Urgun
      member of: Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Orange, California, USA.
  slot:
    index: 2
    item: Qiao J
      type: Person
      first name: Jesse
      last name: Qiao
      member of: Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Orange, California, USA.
  slot:
    index: 3
    item: Mathur G
      type: Person
      first name: Gagan
      last name: Mathur
      member of: Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Orange, California, USA.
  slot:
    index: 4
    item: Tran MH
      type: Person
      first name: Minh-Ha
      last name: Tran
      member of: Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Orange, California, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T04:30
e ISSN: 1537-2995
has issn l: 0041-1132
issue: 2
has NLM journal title abbreviation: Transfusion
publication name: Transfusion
language: eng
has national library of medicine journal id: 0417360
derived from: NLM
starting page: 420
ending page: 421
has place of publication: United States
source: Transfusion. 2025-02;65(2):420-421.
volume: 65

In reply.
pmid: 39950205
doi: 10.1111/trf.18112
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Usmani A
      type: Person
      first name: Amena
      last name: Usmani
      member of: Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.Department of Pathology, University of California San Diego, San Diego, California, USA.
  slot:
    index: 2
    item: Sarode R
      type: Person
      first name: Ravi
      last name: Sarode
      member of: Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.Department of Internal Medicine (Hematology/Oncology), UT Southwestern Medical Center, Dallas, Texas, USA.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T04:30
e ISSN: 1537-2995
has issn l: 0041-1132
issue: 2
has NLM journal title abbreviation: Transfusion
publication name: Transfusion
language: eng
has national library of medicine journal id: 0417360
derived from: NLM
starting page: 421
ending page: 422
has place of publication: United States
source: Transfusion. 2025-02;65(2):421-422.
volume: 65

Letter: Relationships Between Inflammatory Parameters and Quantitative Flow Ratio May Be Misleading Because of Many Confounding Factors.
pmid: 39950213
doi: 10.1177/00033197251321263
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Demirkıran A
      type: Person
      first name: Aykut
      last name: Demirkıran
      member of: Department of Cardiology, Faculty of Medicine Tekirdag Namık Kemal University, Tekirdağ, Turkiye.
  slot:
    index: 2
    item: Aydın C
      type: Person
      first name: Cihan
      last name: Aydın
      member of: Department of Cardiology, Faculty of Medicine Tekirdag Namık Kemal University, Tekirdağ, Turkiye.
  slot:
    index: 3
    item: Orta H
      type: Person
      first name: Hüseyin
      last name: Orta
      member of: Department of Cardiology, Faculty of Medicine Tekirdag Namık Kemal University, Tekirdağ, Turkiye.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:32
e ISSN: 1940-1574
has issn l: 0003-3197
has NLM journal title abbreviation: Angiology
publication name: Angiology
language: eng
has national library of medicine journal id: 0203706
derived from: NLM
pg: 33197251321263
has place of publication: United States
source: Angiology. 2025-02-14;():33197251321263.

Continuing Medical Education.
pmid: 39950206
doi: 10.1111/trf.18142
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T04:30
e ISSN: 1537-2995
has issn l: 0041-1132
issue: 2
has NLM journal title abbreviation: Transfusion
publication name: Transfusion
language: eng
has national library of medicine journal id: 0417360
derived from: NLM
pg: 385
has place of publication: United States
source: Transfusion. 2025-02;65(2):385.
volume: 65

Science capital: Results from a Finnish population survey.
pmid: 39950215
abstract: This study examined science capital among Finnish adults (N = 1572), who responded to 37 survey items assessing science capital. Factor analysis suggested four science capital dimensions: visiting science-related places, science attitudes, science-related self-efficacy, and early support for studying natural sciences. Higher education and higher parental education were linked to higher science capital across all dimensions. Older participants exhibited lower science-related self-efficacy, less early support, and more negative science attitudes than younger respondents. Age and education were stronger predictors of science-related self-efficacy and early encouragement for men than women, and mothers' education had a weaker effect on science-related self-efficacy for men. The results show that science capital is a multidimensional construct and highlights that younger generations in Finland have had more opportunities to develop their science capital. These findings emphasize the need for early and equitable support to foster positive science attitudes and participation.
doi: 10.1177/09636625241310756
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Kaakinen JK
      type: Person
      first name: Johanna K
      last name: Kaakinen
      member of: University of Turku, Finland.
  slot:
    index: 2
    item: Havu-Nuutinen S
      type: Person
      first name: Sari
      last name: Havu-Nuutinen
      member of: University of Eastern Finland, Finland.
  slot:
    index: 3
    item: Häikiö T
      type: Person
      first name: Tuomo
      last name: Häikiö
      member of: University of Turku, Finland.
  slot:
    index: 4
    item: Julku H
      type: Person
      first name: Hanna
      last name: Julku
      member of: University of Helsinki, Finland.
  slot:
    index: 5
    item: Koskela T
      type: Person
      first name: Teija
      last name: Koskela
  slot:
    index: 6
    item: Mikkilä-Erdmann M
      type: Person
      first name: Mirjamaija
      last name: Mikkilä-Erdmann
      member of: University of Turku, Finland.
  slot:
    index: 7
    item: Pihlajamäki M
      type: Person
      first name: Milla
      last name: Pihlajamäki
      member of: University of Helsinki, Finland.
  slot:
    index: 8
    item: Pritup D
      type: Person
      first name: Daria
      last name: Pritup
      member of: University of Turku, Finland.
  slot:
    index: 9
    item: Pulkkinen K
      type: Person
      first name: Kirsi
      last name: Pulkkinen
      member of: Metropolia University of Applied Sciences, Finland.
  slot:
    index: 10
    item: Saarikivi K
      type: Person
      first name: Katri
      last name: Saarikivi
      member of: University of Turku, Finland.
  slot:
    index: 11
    item: Simola J
      type: Person
      first name: Jaana
      last name: Simola
      member of: University of Helsinki, Finland.
  slot:
    index: 12
    item: Wikström V
      type: Person
      first name: Valtteri
      last name: Wikström
      member of: University of Turku, Finland.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:32
e ISSN: 1361-6609
has issn l: 0963-6625
has NLM journal title abbreviation: Public Underst Sci
publication name: Public understanding of science (Bristol, England)
language: eng
has national library of medicine journal id: 9306503
derived from: NLM
pg: 9636625241310756
has place of publication: England
source: Public Underst Sci. 2025-02-14;():9636625241310756.

Correction to Resorbable Engineered Barrier Membranes for Oral Surgery Applications .
pmid: 39950219
doi: 10.1002/jbm.a.37841
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T04:33
e ISSN: 1552-4965
has issn l: 1549-3296
issue: 2
has NLM journal title abbreviation: J Biomed Mater Res A
publication name: Journal of biomedical materials research. Part A
language: eng
has national library of medicine journal id: 101234237
derived from: NLM
pg: e37841
has place of publication: United States
source: J Biomed Mater Res A. 2025-02;113(2):e37841.
volume: 113

Correction to The Mechanics of Cilia and Flagella: What We Know and What We Need to Know .
pmid: 39950226
doi: 10.1002/cm.22003
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:33
e ISSN: 1949-3592
has issn l: 1949-3592
has NLM journal title abbreviation: Cytoskeleton (Hoboken)
publication name: Cytoskeleton (Hoboken, N.J.)
language: eng
has national library of medicine journal id: 101523844
derived from: NLM
has place of publication: United States
source: Cytoskeleton (Hoboken). 2025-02-14;():.

Partial Heart Transplantation in Children: How to Preserve Donor Tissue Longer Than Orthotopic Heart Transplantation.
pmid: 39950248
doi: 10.1111/petr.70046
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Asante-Korang A
      type: Person
      first name: Alfred
      last name: Asante-Korang
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-03
dp: 2025 Mar
created: 2025-2-14T04:43
e ISSN: 1399-3046
has issn l: 1397-3142
issue: 2
has NLM journal title abbreviation: Pediatr Transplant
publication name: Pediatric transplantation
language: eng
has national library of medicine journal id: 9802574
derived from: NLM
pg: e70046
has place of publication: Denmark
source: Pediatr Transplant. 2025-03;29(2):e70046.
volume: 29

Should we express gratitude in human-AI interaction: The online public's moral stance toward artificial intelligence assistants in China.
pmid: 39950240
abstract: The ethical dimensions of human-AI (artificial intelligence) interaction demand attention. As artificial intelligence assistants become more anthropomorphized, will the public interact with AI as humans morally? This study applied content analysis to data from an online question-and-answer platform in China (N = 287) to explore the public's judgments of gratitude toward artificial intelligence assistants. The findings revealed the majority supports expressing gratitude, while a significant minority disagrees, indicating diverse ethical judgments. By further analyzing people's reasoning, this study found that supporters attribute gratitude to moral autonomy driven by virtue ethics, moral responsibility for responsible AI, and the perceived source identity of anthropomorphized AI as human, aligning with the Computers-are-Social-Actors paradigm. In contrast, opponents doubt AI's moral agency, highlighting the perceived source of AI as machines, and they judge that treating it with human manners is useless and potentially dangerous. These insights enhance the understanding of the public's view of ethical considerations regarding AI assistants, contribute to gratitude research in the context of human-AI interaction, extend the moral dimension of the Computers-are-Social-Actors paradigm, and emphasize the importance of moral and responsible AI use. Suggestions for future research based on the exploratory findings are also discussed.
doi: 10.1177/09636625251314337
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Zhu Y
      type: Person
      first name: Yuqi
      last name: Zhu
      member of: University of Science and Technology of China, China.
  slot:
    index: 2
    item: Chu J
      type: Person
      first name: Jianxun
      last name: Chu
      member of: University of Science and Technology of China, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:34
e ISSN: 1361-6609
has issn l: 0963-6625
has NLM journal title abbreviation: Public Underst Sci
publication name: Public understanding of science (Bristol, England)
language: eng
has national library of medicine journal id: 9306503
derived from: NLM
pg: 9636625251314337
has place of publication: England
source: Public Underst Sci. 2025-02-14;():9636625251314337.

Traditional and alternative scores in performance tests to measure executive functions: differential associations with children's academic performance.
pmid: 39950258
abstract: This study explores the relationship between children's academic performance and their results on cognitive function tests. Traditionally, cognitive test scores often reflect overall accuracy or speed. Yet, these overall scores are often influenced by both diverse executive functions (EF) and non-EF cognitive processes. To isolate specific cognitive functions, alternative scoring methods have been developed, which aim to measure one cognitive function more purely. We investigated whether combining traditional overall scores with alternative scores claiming to measure strategy use improves the prediction of children's academic performance. Three cognitive tests were administered: Verbal Fluency test, Design Fluency test, and Rey-Osterrieth Complex Figure test, alongside factors such as age, IQ, sex, and parental education, in a sample of 132 Dutch-speaking children (aged 9.48-12.63 years; 61 girls). For each test, we calculated traditional total scores and alternative scores. Academic performance was assessed using arithmetic and reading tests, along with secondary school advice. The findings indicate that both traditional and alternative scores positively correlate with secondary school advice and children's arithmetic and reading performance, but not with parental reports. Combining traditional and alternative scores enhances predictive accuracy for only arithmetic outcomes. However, once IQ was controlled for, the predictive value of alternative scores focused on strategy use diminished. Consequently, our findings suggest that combining both scoring methods can offer a superior prediction of academic outcomes, at least in arithmetic, underscoring their merit in psychodiagnostics assessment.
doi: 10.1080/09297049.2025.2462094
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hou W
      type: Person
      first name: Wenying
      last name: Hou
      member of: Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
  slot:
    index: 2
    item: Resch C
      type: Person
      first name: Christine
      last name: Resch
      member of: Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
  slot:
    index: 3
    item: Möckel R
      type: Person
      first name: Rico
      last name: Möckel
      member of: Department of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands.
  slot:
    index: 4
    item: Borghans L
      type: Person
      first name: Lex
      last name: Borghans
      member of: Department of Macro, International, and Labour Economics, School of Business and Economics, Maastricht University, Maastricht, The Netherlands.
  slot:
    index: 5
    item: Hurks PPM
      type: Person
      first name: Petra P M
      last name: Hurks
      member of: Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T04:53
e ISSN: 1744-4136
has issn l: 0929-7049
has NLM journal title abbreviation: Child Neuropsychol
publication name: Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
language: eng
has national library of medicine journal id: 9512515
derived from: NLM
starting page: 1
ending page: 33
has place of publication: England
source: Child Neuropsychol. 2025-02-14;():1-33.

Mitochondrial Dysfunction: Potential Therapy For Abdominal Aortic Aneurysms.
pmid: 39950265
abstract: Abdominal Aortic Aneurysm (AAA) is a life-threatening vascular disease. Despite advancements in understanding the pathogenesis of AAA, significant knowledge gaps persist. Recent evidence increasingly implicates mitochondrial dysfunction as a contributing factor that exacerbates AAA, inducing further expansion of aneurysm, rupture, and subsequent death. This review summarizes the latest research findings and theories associated with AAA pathogenesis, with a particular focus on mitochondrial dysfunction in AAA, including mitochondrial quality control, mitochondrial membrane potential, mitochondrial morphology, oxidation and antioxidation, normal functioning of the respiratory chain, mitochondrial mutations, and the regulation of other mitochondrial signaling pathways. Moreover, we highlight potential medical interventions based on regulating mitochondrial function for AAA treatment.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CVP-EPUB-146520
doi: 10.2174/0115701611312293241220101556
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Yang W
      type: Person
      first name: Wenfan
      last name: Yang
      member of: Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.
  slot:
    index: 2
    item: He J
      type: Person
      first name: Jianxiong
      last name: He
      member of: Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.
  slot:
    index: 3
    item: Yu H
      type: Person
      first name: Hao
      last name: Yu
      member of: Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.
  slot:
    index: 4
    item: Wu Y
      type: Person
      first name: Ya
      last name: Wu
      member of: Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.Metabolic Vascular Disease Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.
  slot:
    index: 5
    item: Shi S
      type: Person
      first name: Sen
      last name: Shi
      member of: Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.Metabolic Vascular Disease Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, China.Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases,) Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1875-6212
has issn l: 1570-1611
has NLM journal title abbreviation: Curr Vasc Pharmacol
publication name: Current vascular pharmacology
language: eng
has national library of medicine journal id: 101157208
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Vasc Pharmacol. 2025-02-10;():.

The ER Stress-related Gene Prognostic Signature for Predicting Chemosensitivity and Prognosis in AML.
pmid: 39950268
abstract: Acute myeloid leukemia is characterized by high heterogeneity, and the current European Leukemia Net (ELN) risk stratification system is not universally applicable to all AML patients, requiring approximately three weeks for testing.This study aimed to develop an applicable prognostic tool capable of addressing the limitations of current methods. We selected AML patients from the clinic and TCGA database to explore the role of ER stress in response to chemotherapy.Patients from the TCGA database were employed as the training cohort, and two GEO datasets were used as external validation cohorts. Univariate/multivariate COX and LASSO regression were exemplified to establish the prognostic model. Kaplan-Meier and timedependent ROC were used to assess and compare the efficiency of the model with ELN stratification and other models. In the training cohort, we selected 5 ER stress-related genes to predict chemosensitivity and establish the ERS-5 prognostic model.The model successfully predicted the overall survival of patients (p < 0.0001, HR = 4.86 (2.79-8.44); AUC = 0.83). It was verified in validation cohorts and could further stratify the risk of various AML subgroups. It also enhanced the ability of ELN to predict the response of patients with AML to main chemotherapeutic drugs. Finally, an ERS-5 risk score was constructed by the nomogram based on the ERS-5 model and age.Consequently, in this study, the ERS-5 model was constructed, which allowed more rapid (about 3 hours) and accurate risk stratification and complemented the ability of ELN to assess chemosensitivity.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: PRA-EPUB-146496
doi: 10.2174/0115748928349165250202172440
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Guo J
      type: Person
      first name: Jie
      last name: Guo
      member of: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 10005, P.R. China.Graduate School, Chinese Academy of Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China.Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, 10005, P.R. China.
  slot:
    index: 2
    item: Peng H
      type: Person
      first name: Hongwei
      last name: Peng
      member of: Department of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, P.R. China.
  slot:
    index: 3
    item: Long L
      type: Person
      first name: Luyao
      last name: Long
      member of: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 10005, P.R. China.Graduate School, Chinese Academy of Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China.Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, 10005, P.R. China.
  slot:
    index: 4
    item: Sun L
      type: Person
      first name: Li
      last name: Sun
      member of: Department of Hematology, Key Laboratory of Hematology of Hebei, The second hospital of Hebei Medical University. Shijiazhuang, 050000, P.R. China.
  slot:
    index: 5
    item: Yang L
      type: Person
      first name: Lin
      last name: Yang
      member of: Department of Hematology, Key Laboratory of Hematology of Hebei, The second hospital of Hebei Medical University. Shijiazhuang, 050000, P.R. China.
  slot:
    index: 6
    item: Ren S
      type: Person
      first name: Simei
      last name: Ren
      member of: National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 10005, P.R. China.Graduate School, Chinese Academy of Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China.Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, 10005, P.R. China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 2212-3970
has issn l: 1574-8928
has NLM journal title abbreviation: Recent Pat Anticancer Drug Discov
publication name: Recent patents on anti-cancer drug discovery
language: eng
has national library of medicine journal id: 101266081
derived from: NLM
has place of publication: United Arab Emirates
source: Recent Pat Anticancer Drug Discov. 2025-02-07;():.

A Pharmacological Update of Oxadiazole Derivatives: A Review.
pmid: 39950279
abstract: Recent advancements in the synthesis of novel heterocyclic compounds, particularly oxadiazole derivatives, have garnered significant interest due to their broad pharmacological activities. Despite the oxadiazole ring being a relatively small structure, its derivatives have shown considerable therapeutic potential across a range of diseases. These compounds have been explored for a variety of biological effects, including anti-inflammatory, anticonvulsant, hypoglycemic, antitubercular, anxiolytic, antimicrobial, antitumor, and anticancer properties. The growing issue of drug resistance has further fueled research into the therapeutic promise of oxadiazolebased compounds, particularly for their ability to target resistant diseases.This review aims to highlight the pharmacological profiles of oxadiazole derivatives, with a focus on how structural modifications can enhance their activity against specific therapeutic targets. Additionally, the review seeks to explore strategies for overcoming resistance mechanisms associated with these compounds, underscoring their potential in addressing emerging drugresistant diseases.Oxadiazole derivatives represent a promising class of compounds with significant therapeutic potential, particularly in the face of increasing drug resistance. Their diverse pharmacological activities and ability to be structurally optimized for specific therapeutic targets position them as valuable candidates for further research. Continued exploration of oxadiazole derivatives, with an emphasis on overcoming resistance, may lead to the development of novel treatments for a variety of challenging diseases.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-146524
doi: 10.2174/0115680266349715250122001314
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Mohan M
      type: Person
      first name: Magesh
      last name: Mohan
      member of: Department of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu 602105, India.
  slot:
    index: 2
    item: Rathinasamy G
      type: Person
      first name: Gandhimathi
      last name: Rathinasamy
      member of: Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.
  slot:
    index: 3
    item: Devarajan B
      type: Person
      first name: Bharathi
      last name: Devarajan
      member of: Department of Pharmaceutical Chemistry Faculty of Pharmacy, Bharath Institute of Higher Education and Research, SBMCH, Chromepet.
  slot:
    index: 4
    item: Byran G
      type: Person
      first name: Gowramma
      last name: Byran
      member of: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu, India.
  slot:
    index: 5
    item: Lakshmanan K
      type: Person
      first name: Kaviarasan
      last name: Lakshmanan
      member of: School of Pharmacy, Sathyabama Institute of Science and Technology, Chennai.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-10;():.

The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides.
pmid: 39950278
abstract: The escalating growth and global dissemination of antimicrobial resistance underscore the urgency for the discovery of innovative antimicrobial agents. Antibacterial Peptides (AMPs) have emerged as promising candidates, distinctly outperforming conventional antibiotics due to their mitigated propensity for resistance development, expansive antibiofilm activity, and capacity to favorably modulate host immune responses. Consequently, AMPs have garnered significant attention in medical research circles and are anticipated to serve as novel therapeutic alternatives in combating microbial infections, particularly those involving drug-resistant bacteria, thereby inaugurating a novel paradigm in treatment strategies. This comprehensive review delves into the intricate structural and physicochemical attributes of AMPs, providing a concise overview. It further examines the advancements and anticipated clinical trajectories of AMP research, with a pivotal focus on elucidating their antimicrobial mechanisms and the intricate interplay between structure and activity. The aim of this review is twofold: firstly, to enhance the scientific community's comprehension of the antimicrobial mechanisms and Structure-Activity Relationships (SAR) across all classes of AMPs; secondly, to address existing research gaps in the SAR of AMPs, thereby laying a solid foundation for future research endeavors and facilitating the development of these promising therapeutic agents.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-146474
doi: 10.2174/0115680266350153250121072651
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zhong H
      type: Person
      first name: Hanyu
      last name: Zhong
      member of: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.
  slot:
    index: 2
    item: Chen X
      type: Person
      first name: Xingjun
      last name: Chen
      member of: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.
  slot:
    index: 3
    item: Han S
      type: Person
      first name: Sili
      last name: Han
      member of: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.
  slot:
    index: 4
    item: Zhang L
      type: Person
      first name: Linglin
      last name: Zhang
      member of: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-07;():.

Recent Advancements in Breast Cancer Therapies and Biomarkers: Mechanisms and Clinical Significance.
pmid: 39950270
abstract: Breast cancer remains a critical health concern, requiring continual innovation in treatment to improve patient outcomes. The continuous obstacles in therapy and the need for novel techniques underline the importance of making advances in this discipline. Precision medicine has emerged as a viable method, with genomic profiling and molecular subtyping allowing for targeted therapy based on distinct breast cancer subtypes. This strategy is supplemented by advances in early detection and screening, with technologies like liquid biopsy promising earlier and more accurate diagnosis. The introduction of immunotherapy has transformed breast cancer treatment by using the body's immune system to combat cancer. Recent discoveries, particularly combination medicines, attempt to circumvent resistance mechanisms and improve treatment success. Furthermore, including lifestyle therapies such as nutrition, exercise, and psychological support has been demonstrated to reduce breast cancer risk and strengthen survivability rates. Survivorship programs serve an important role in comprehensive care by addressing long-term needs and enhancing survivors' quality of life. Investigating innovative therapeutic approaches, such as developing cancer vaccines, epigenetic modulators, and RNA interference (RNAi) therapy, provides new treatment options. Fostering collaboration among healthcare personnel through shared decision-making and tumor committees is essential for the integration of multidisciplinary care, which ensures patientcentered care. Although advancements have been made, there are still numerous obstacles to overcome in the implementation of these future directions. To effectively confront these obstacles, it is imperative to capitalize on opportunities for innovation and collaboration. It is imperative to address ethical, social, and economic factors in the advancement of breast cancer care to ensure that innovations are equitable and accessible. In conclusion, the future of breas[cell cut: 2484 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146490
doi: 10.2174/0113892010343901250204054241
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Husain A
      type: Person
      first name: Arbab
      last name: Husain
      member of: Department of Biotechnology & Life Sciences, Faculty of Sciences, Mangalayatan University, Aligarh-202146, Uttar Pradesh, India.
  slot:
    index: 2
    item: Khan H
      type: Person
      first name: Hamda
      last name: Khan
      member of: Department of Biochemistry, Faculty of Medicine, Jawahar Lal Nehru Medical College, 202002, Aligarh Muslim University, Aligarh- 202002, India.
  slot:
    index: 3
    item: Jamale E Fatima
      type: Person
      last name: Jamale E Fatima
      member of: School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.
  slot:
    index: 4
    item: Siddiqui SA
      type: Person
      first name: Shirjeel Ahmad
      last name: Siddiqui
      member of: Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh, India.
  slot:
    index: 5
    item: Singh AD
      type: Person
      first name: Akash Deep
      last name: Singh
      member of: Department of Paramedical Sciences, Mangalayatan University, Aligarh-202146, Uttar Pradesh, India.
  slot:
    index: 6
    item: Husain A
      type: Person
      first name: Adil
      last name: Husain
      member of: Department of Biosciences, Integral University, Lucknow-226026, Uttar Pradesh, India.
  slot:
    index: 7
    item: Pandey S
      type: Person
      first name: Shivam
      last name: Pandey
      member of: School of Applied and Life Sciences, Uttaranchal University, Dehradun.
  slot:
    index: 8
    item: Kant R
      type: Person
      first name: Ravi
      last name: Kant
      member of: Department of Chemistry, Institute of Applied Science, Mangalayatan University, Aligarh-202146, Uttar Pradesh, India.
  slot:
    index: 9
    item: Khanam A
      type: Person
      first name: Afreen
      last name: Khanam
      member of: Department of Biotechnology & Life Sciences, Faculty of Sciences, Mangalayatan University, Aligarh-202146, Uttar Pradesh, India.
  slot:
    index: 10
    item: Pandey P
      type: Person
      first name: Pratibha
      last name: Pandey
      member of: Centre of Research Impact and Outcome, Chitkara University, Rajpura- 140417, Punjab, India.
  slot:
    index: 11
    item: Khan F
      type: Person
      first name: Fahad
      last name: Khan
      member of: Center for Global Health Research Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-07;():.

Linking Processed and Red Meat Consumption to Specific Lung Cancer Subtypes: A Mendelian Randomization Analysis.
pmid: 39950269
abstract: The aim of this study was to elucidate the causal relationship between the consumption of processed and red meats (specifically pork, beef, and mutton) and susceptibility to various lung cancer types.Previous observational studies have indicated a potential cancer risk associated with red and processed meat consumption. However, a clear causal relationship remains undetermined.Refining the study of the association between processed and red meat and lung cancer using a Mendelian randomization study.We harnessed the robustness of Two-Sample Mendelian Randomization, integrating data from the esteemed UK Biobank, capturing dietary habits with oncological datasets from the Transdisciplinary Research In Cancer of the Lung. The analytical approach was anchored in the inverse variance weighted (IVW) method, enriched by sensitivity analyses for result validation.Genetic predispositions favoring processed meat consumption are linked to heightened risks of lung cancer [IVW analysis, OR=1.8203, 95%CI [1.1115,2.9811], p=0.0173], and in LUSC [IVW analysis, OR=2.9274, 95%CI [1.4810,5.7863], p=0.0020]. Beef was more important in lung cancer [IVW analysis, OR=4.6739, 95% CI [2.4947, 8.7570], p=0.000001], in LUSC [IVW analysis, OR=3.3251, 95%CI [1.2055,9.1717], p=0.0203] and in LUAD [IVW analysis, OR=7.1480, 95%CI [3.0074,16.9893], p=0.000008]. However, no significant links were identified between mutton or pork intake and lung cancer.Processed meat and beef consumption may elevate lung cancer risk. Additional research is warranted to investigate potential links between mutton or pork consumption and the risk of lung cancer.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146465
doi: 10.2174/0113892010338630241217104104
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Wen K
      type: Person
      first name: Kang
      last name: Wen
      member of: Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.
  slot:
    index: 2
    item: Wang Z
      type: Person
      first name: Zhaoxia
      last name: Wang
      member of: Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-07;():.

Discovery of the PARP1 Inhibitors from Natural Compounds Using Structure-Based Virtual Screening and Bioactivity Evaluation.
pmid: 39950277
abstract: PARP1 (poly ADP-ribose polymerase 1, also known as ADPRT1) plays a significant role in DNA repair and has become an attractive target for treating PARP1-related diseases, such as cancer.This study aimed to discover inhibitors targeting PARP1 from the phytochemicals of Huangbai (Phellodendron chinense Schneid.), Baixianpi (Dictamnus dasycarpus Turcz.), and Shechuangzi (Cnidium monnieri (L.) Spreng.).The chemical compositions of Huangbai, Baixianpi, and Shechuangzi were extracted from the HERB database. Next, a combination of molecular docking and PARP1 enzyme assay was used to identify PARP1 inhibitors from these chemical components. Finally, molecular dynamics simulation and binding free energy calculation were used to explore the detailed interaction mode of these inhibitors with PARP1.A total of 507 chemical constituents of Huangbai, Baixianpi, and Shechuangzi were collected from the HERB database. Four potential PARP1 inhibitors were screened based on molecular docking and PARP1 enzyme assay. Demethyleneberberine exhibited strong PARP1 inhibitory activity with an IC50 value of 2.0 ± 0.8 μM. The IC50 values of the inhibitory activities of 8-hydroxy dictanmnine, meranzin hydrate, and osthol on PARP1 ranged from 44 μM to 76 μM. Molecular dynamics simulation and binding free energy calculation suggested that the nonpolar interaction energies of HIS862, GLY863, TYR889, TYR896, PHE897, and TYR907 played a primary role in the binding of inhibitors to PARP1.Integrating molecular simulation and bioactivity testing was found to be an effective approach for the rapid discovery of targeted PARP1 inhibitors. Demethyleneberberine demonstrated strong PRAP1 inhibitory activity and has a good prospect for development.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: MC-EPUB-146457
doi: 10.2174/0115734064350048241121110017
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Pan D
      type: Person
      first name: Dabo
      last name: Pan
      member of: Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
  slot:
    index: 2
    item: Huang Y
      type: Person
      first name: Yaxuan
      last name: Huang
      member of: Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
  slot:
    index: 3
    item: Jiang D
      type: Person
      first name: Dewen
      last name: Jiang
      member of: Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
  slot:
    index: 4
    item: Jin X
      type: Person
      first name: Xiaojie
      last name: Jin
      member of: College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China.
  slot:
    index: 5
    item: Wu M
      type: Person
      first name: Mingkai
      last name: Wu
      member of: Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
  slot:
    index: 6
    item: Luo J
      type: Person
      first name: Jianjun
      last name: Luo
      member of: The Affiliated Dazu's Hospital of Chongqing Medical University, Dazu 402360, China.
  slot:
    index: 7
    item: Zhang Y
      type: Person
      first name: Yonghao
      last name: Zhang
      member of: Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1875-6638
has issn l: 1573-4064
has NLM journal title abbreviation: Med Chem
publication name: Medicinal chemistry (Shariqah (United Arab Emirates))
language: eng
has national library of medicine journal id: 101240303
derived from: NLM
has place of publication: Netherlands
source: Med Chem. 2025-02-07;():.

The Suicide Gene System Cytosine Deaminase::Uracylphosphoribosyltransferase/ 5-fluorocytosine Displays a Strong Cytotoxic Effect on Human Melanoma Cells.
pmid: 39950271
abstract: Melanoma is considered the deadliest form of skin cancer. While monoclonal-antibodies and molecular targets marked milestones in melanoma therapy, more research is needed to overcome the advanced stages of this disease.To explore the possible use of the yeast cytosine deaminase::uracil phosphoribosyltransferase fusion enzyme/5-fluorocytosine (CD::UPRT/5FC) suicide gene (SG) system for human melanoma.In eight metastatic human melanoma cell lines, we determined: cytotoxicity, lipofection efficiencies, colony forming capacity and bystander effects due to soluble and/or particulate factors secreted to the conditioned media after treatments.CD::UPRT induced cell death in a prodrug (5FC) concentration-dependent manner and was able to eliminate the sub-population of surviving cells with clonogenic capacity. Compared with human interferon-β gene transfer or the herpes simplex virus thymidine kinase/ganciclovir system, at 100 μM 5FC, CD::UPRT was more efficient in inducing cell death. The strong cytotoxic response contrasted with the low lipofection efficiencies (<5%), indicating a potent bystander effect. We analyzed the contribution of soluble and particulate factors released by SG lipofected cells to the conditioned media (CM) finding that they were able to deliver CD::UPRT genetic information and/or recombinant enzyme to recipient cells. When exposed to 5FC, the cells that received either supernatant or 12000×g pellet fractions of CM, efficiently activated the prodrug because of the acquired CD::UPRT activity and caused cell death.This suicide gene therapy approach, amplified by the release of free 5-fluorouracil and soluble and particulate factors containing CD::UPRT genetic information and/or enzyme, could have a great clinical potential for malignant melanoma.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146464
doi: 10.2174/0113892010319891241121115002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Bernabei-Cornejo SG
      type: Person
      first name: Sofía Gala
      last name: Bernabei-Cornejo
      member of: Unidad de Transferencia Genética, Instituto de Oncología 'Ángel H. Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina.
  slot:
    index: 2
    item: Glikin GC
      type: Person
      first name: Gerardo Claudio
      last name: Glikin
      member of: Unidad de Transferencia Genética, Instituto de Oncología 'Ángel H. Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina.
  slot:
    index: 3
    item: Finocchiaro LME
      type: Person
      first name: Liliana María Elena
      last name: Finocchiaro
      member of: Unidad de Transferencia Genética, Instituto de Oncología 'Ángel H. Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-07;():.

In silico Identification and Computational Screening of Potential AFP Inhibitors Against Liver Cancer.
pmid: 39950276
abstract: Liver cancer is considered one of the most common types of cancer and a major cause of ephemerality worldwide having a higher prevalence rate in Asia and sub-Saharan Africa. The alpha-fetoprotein (AFP) is a serum glycoprotein that belongs to a class of oncodevelopmental proteins and is also involved in tumor formation.In the current effort, a hybrid approach of virtual screening followed by pharmacophore generation and molecular dynamic simulation analyses were performed. The screened top-ranked 10 docked compounds from the selected anti-cancer compound library were utilized to generate the ligand-based pharmacophore. Virtual screening was performed two-dimensional similarity search against the selected natural compound library based on their physicochemical properties. It was observed that all the compounds from the anti-cancer compound library and natural compound library showed similar binding resides.Therefore, the top-ranked screened compounds that showed the least binding energy and highest binding affinity against AFP, obtained through the anti-cancer drug library and natural compound library were reported. The molecular docking analyses revealed that Leu-219, His-222, Lys-242, Lys-246, His-316, Glu-318, Ala-366, Val-367, Gly-475, Ile-479, Ala-471, Asp-478 were observed as potential residues for interaction.The observed results of virtual screening, molecular docking, and MD simulation analyses entail noteworthy observations illustrating that NC002 was a potent inhibitor. The proposed compound NC002 may have potential against liver cancer by targeting AFP based on MD simulation analyses, PCA, and MM-GBSA.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: MC-EPUB-146502
doi: 10.2174/0115734064330103250106034126
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Waseem HB
      type: Person
      first name: Hassan Bin
      last name: Waseem
      member of: Department of Bioinformatics, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
  slot:
    index: 2
    item: Shakeel M
      type: Person
      first name: Muhammad
      last name: Shakeel
      member of: Department of Biochemistry and Molecular Biology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
  slot:
    index: 3
    item: Hassan FU
      type: Person
      first name: Faiz-Ul
      last name: Hassan
      member of: Department of Breeding and Genetics, Faculty of Animal Production and Technology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
  slot:
    index: 4
    item: Yaqoob A
      type: Person
      first name: Asma
      last name: Yaqoob
      member of: Department of Biochemistry and Molecular Biology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
  slot:
    index: 5
    item: Iqbal A
      type: Person
      first name: Azhar
      last name: Iqbal
      member of: Department of Biotechnology, University of Okara, Okara, Punjab, Pakistan.
  slot:
    index: 6
    item: Khalid A
      type: Person
      first name: Amina
      last name: Khalid
      member of: Department of Biotechnology, University of Okara, Okara, Punjab, Pakistan.
  slot:
    index: 7
    item: Akram HN
      type: Person
      first name: Hafiza Nisha
      last name: Akram
      member of: Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
  slot:
    index: 8
    item: Dilbar N
      type: Person
      first name: Noshaba
      last name: Dilbar
      member of: Department of Biochemistry and Molecular Biology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.Department of Botany, Government. Sadiq College Women University, Bahawalpur, Pakistan.
  slot:
    index: 9
    item: Qamar S
      type: Person
      first name: Saad
      last name: Qamar
      member of: Department of Biochemistry and Molecular Biology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.Department of Homoeopathic, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  slot:
    index: 10
    item: Tahir RA
      type: Person
      first name: Rana Adnan
      last name: Tahir
      member of: Department of Biology, Sultan Qaboos University, Muscat, Oman.
  slot:
    index: 11
    item: Sehgal SA
      type: Person
      first name: Sheikh Arslan
      last name: Sehgal
      member of: Department of Genomics and Bioinformatics, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1875-6638
has issn l: 1573-4064
has NLM journal title abbreviation: Med Chem
publication name: Medicinal chemistry (Shariqah (United Arab Emirates))
language: eng
has national library of medicine journal id: 101240303
derived from: NLM
has place of publication: Netherlands
source: Med Chem. 2025-02-10;():.

Unveiling the Anticancer Potential of Phytocompounds: Pioneering Future Cancer Therapies.
pmid: 39950280
abstract: Cancer epidemiological studies highlight the critical need for identifying better treatment options against cancer. Plants have been widely studied to obtain their efficacy as potent therapeutic agents to treat several diseases, including cancer. Interestingly, some phytocompounds, such as flavonoids, terpenoids, alkaloids, phenolics, and organosulphur compounds [OSCs], have been demonstrating their potential role in combating several pathologies, including the second most devasting disease, cancer, which contributes a significant portion of annual mortality cases. Several in vitro, in vivo, and in silico investigations have recently established remarkable properties of phytocompounds such as antioxidant effects, induction of apoptosis, inhibition of metastasis, autophagy modulation, cell cycle regulation, and chemosensitization that lead to cancer suppression. This underscores the great potential of phytocompounds to contribute as an effective anticancerous drug for the prevention of cancer cases and advancement in cancer research. Therefore, comprehending the complicated mechanism involved in the anticancerous effects of phytocompounds against several carcinomas is crucial to establishing novel therapeutic strategies. Thus, this review tends to summarize the involvement of the most promising classes of phytompounds in cancer management and highlights several clinical trial data that demonstrate significant results in managing diverse carcinomas.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-146493
doi: 10.2174/0115680266354680250121154720
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Chauhan P
      type: Person
      first name: Prashant
      last name: Chauhan
      member of: MPA Research, Greater Noida, Uttar Pradesh, India.
  slot:
    index: 2
    item: Pandey P
      type: Person
      first name: Pratibha
      last name: Pandey
      member of: Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura- 140401, Punjab, India.
  slot:
    index: 3
    item: Ramniwas S
      type: Person
      first name: Seema
      last name: Ramniwas
      member of: Department of Biotechnology, University Centre of Research and Development, Chandigarh University Gharuan, Mohali, Punjab.
  slot:
    index: 4
    item: Verma M
      type: Person
      first name: Meenakshi
      last name: Verma
      member of: Department of Biotechnology, University Centre of Research and Development, Chandigarh University Gharuan, Mohali, Punjab.
  slot:
    index: 5
    item: Ganeshan S
      type: Person
      first name: Subbulakshmi
      last name: Ganeshan
      member of: Department of Chemistry and Biochemistry, School of Sciences, JAIN [Deemed to be University], Bangalore, Karnataka, India.
  slot:
    index: 6
    item: Rajotiya S
      type: Person
      first name: Sumit
      last name: Rajotiya
      member of: NIMS Institute of Pharmacy, NIMS University, Rajasthan, Jaipur, India.
  slot:
    index: 7
    item: Devi S
      type: Person
      first name: Seema
      last name: Devi
      member of: Chandigarh Pharmacy College, Chandigarh group of colleges, Jhanjeri, Mohali 140307, Punjab, India.
  slot:
    index: 8
    item: Lakhanpal S
      type: Person
      first name: Sorabh
      last name: Lakhanpal
      member of: School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab.
  slot:
    index: 9
    item: Kumar MR
      type: Person
      first name: M Ravi
      last name: Kumar
      member of: Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh-531162, India.
  slot:
    index: 10
    item: Pandey S
      type: Person
      first name: Shivam
      last name: Pandey
      member of: Department of Life Sciences, School of Applied and Life Sciences, Uttaranchal University, Dehradun.
  slot:
    index: 11
    item: Khan F
      type: Person
      first name: Fahad
      last name: Khan
      member of: Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of medical and Technical Sciences, Chennai, Tamil Nadu, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-07;():.

Unlocking the Biological Potential of 2-Pyridones: Synthesis, Antioxidant and Antimicrobial Activity of N-Phenacylated 5/6-Chloro-2-pyridones.
pmid: 39950275
abstract: A simple and efficient synthesis of 14 new (9a-9n) N-phenacyl-2-pyridones with good yields (up to 75%), is reported. The synthesized derivatives were screened for their in vitro radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), their in vitro antimicrobial potential was tested against human pathogenic bacterial strains, including Bacillus cereus, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, as well as the fungal strain Candida albicans.All compounds displayed modest antioxidant activity, with compound 9b being the most potent in the DPPH radical scavenging assay. Most of the synthesized compounds exhibited good to excellent antimicrobial activity, however, the compounds (9d, and 9b) showed maximum inhibition zone diameters of 18.75, and 18.25mm respectively, demonstrating better antimicrobial potential than the standard drug streptomycin against Staphylococcus aureus.However, the compound 9f was found most effective against Pseudomonas aeruginosa with a 23.25 mm zone of inhibition against a 17.50 mm zone of inhibition of the standard, streptomycin. Molecular docking of the compounds 9d and 9f with tyrosyl-tRNA synthetase revealed good binding with the target.The electron-withdrawing substituents on the aryl ring of synthesized N-phenacyl-2- pyridones improved the antioxidant activity, however, for Gram-positive bacteria, less lipophilic or more hydrophilic substituents, such as halogens, displayed better antimicrobial activity. Similarly, it was the more lipophilic substitutions on the aryl ring that improved the antimicrobial activity against Gram-negative bacteria.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: MC-EPUB-146459
doi: 10.2174/0115734064336556250116195638
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Sangwan S
      type: Person
      first name: Sarita
      last name: Sangwan
      member of: Department of Chemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Haryana, 125004, India.
  slot:
    index: 2
    item: Chauhan S
      type: Person
      first name: Sonu
      last name: Chauhan
      member of: Department of Chemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Haryana, 125004, India.
  slot:
    index: 3
    item: Yadav N
      type: Person
      first name: Neelam
      last name: Yadav
      member of: Department of Chemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Haryana, 125004, India.
  slot:
    index: 4
    item: Kumar R
      type: Person
      first name: Ravi
      last name: Kumar
      member of: Department of Chemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Haryana, 125004, India.
  slot:
    index: 5
    item: Duhan A
      type: Person
      first name: Anil
      last name: Duhan
      member of: Department of Chemistry, College of Basic Sciences and Humanities, Chaudhary Charan Singh Haryana Agricultural University, Haryana, 125004, India.
  slot:
    index: 6
    item: Malik V
      type: Person
      first name: Vinod
      last name: Malik
      member of: Department of Plant Pathology, College of Agriculture, Chaudhary Charan Singh Haryana Agricultural University, Haryana, 125004, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1875-6638
has issn l: 1573-4064
has NLM journal title abbreviation: Med Chem
publication name: Medicinal chemistry (Shariqah (United Arab Emirates))
language: eng
has national library of medicine journal id: 101240303
derived from: NLM
has place of publication: Netherlands
source: Med Chem. 2025-02-07;():.

In vivo and In Silico Pharmacokinetics Studies on Coumarinolignoid Cliv-92: Unraveling its Effect on Rifampicin-Induced Hepatic Damage.
pmid: 39950281
abstract: Drug-induced hepatotoxicity is a major concern and is caused by all classes of medications, indicating a key area of research. Antitubercular drugs have a beneficial effect but cause hepatotoxicity on prolonged use.The present work aimed to investigate the role of rifampicin-induced hepatic damage and the effect of Cliv-92 on rifampicin-induced alteration in rats.Rats were administered with rifampicin, Cliv-92, and silymarin (standard) orally in 0.5% carboxymethyl cellulose (CMC) suspension, in doses of 100 mg/kg, once daily for fourteen days, one hour before the administration of rifampicin. Control animals were treated with 0.5% CMC. On the 14th day, 1hr after the last drug administration, tissue was collected, homogenized, and various parameters, viz. SOD, CAT, GPX, and cytochromes, were estimated from rat liver supernatant and compared with the control group. Blood serum parameters were also measured. Simultaneously, antioxidant activity and in silico studies were performed. The constituent isoforms of Cliv-92 and silymarin and their metabolites were analyzed for different pharmacokinetic characteristics. Silymarin was used as a standard drug.The result of the study suggests that the hepatoprotective potential of Cliv-92 is due to its antioxidant property and inhibitory effect on hepatoproteins, cytochromes (CPY450). An in-silico finding validates the safety profile of Cliv-92, its metabolites, and the standard drug silymarin and also explains that the drug is non-mutagenic.The result of this study indicated that both Cliv-92 and silymarin could be used to avoid drug-induced overload and hepatic damage.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-146548
doi: 10.2174/0115680266329609241223114551
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Kumar A
      type: Person
      first name: Ajay
      last name: Kumar
      member of: Molecular Bioprospection & Product Development Division.
  slot:
    index: 2
    item: Alam S
      type: Person
      first name: Sarfaraz
      last name: Alam
      member of: Technology Dissemination & Computational Biology Division.
  slot:
    index: 3
    item: Tandon S
      type: Person
      first name: Sudeep
      last name: Tandon
      member of: Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, P.O.- CIMAP, Kukrail Picnic Spot Road, Lucknow -226015, (U.P.), India.
  slot:
    index: 4
    item: Shanker K
      type: Person
      first name: Karuna
      last name: Shanker
      member of: Government Pharmacy College, BRD Medical College campus, Gorakhpur, 273013, (U.P.), India.
  slot:
    index: 5
    item: Khan F
      type: Person
      first name: Feroz
      last name: Khan
      member of: Technology Dissemination & Computational Biology Division.
  slot:
    index: 6
    item: Saikia D
      type: Person
      first name: Dharmendra
      last name: Saikia
      member of: Molecular Bioprospection & Product Development Division.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-10;():.

Application of Probiotics and Postbiotics in Neurological Disorders.
pmid: 39950272
abstract: Neurological illnesses encompass a broad spectrum of conditions that affect the brain, spine, and nerves, often impairing daily functioning. The global prevalence of these illnesses is rising, posing significant health challenges. This study investigates the beneficial effects of probiotics and postbiotics in managing various neurological disorders, providing a comprehensive analysis of their use in treating these conditions. The article explores innovative, holistic approaches to neurological care, emphasizing patient-centered therapeutic interventions. Compelling evidence suggests that probiotics and postbiotics positively impact several neurological diseases. Specifically, the findings indicate that these treatments can modulate the gut-brain axis, reduce neuroinflammation, and enhance neuronal protection. The study highlights the potential of specific bacteria and their byproducts to ameliorate neurological disorders. Despite promising results, the current data underscore the challenges in future research on the therapeutic benefits of probiotics and postbiotics for neurological illnesses and underscores the critical role of the gut-brain connection and the microbiome in maintaining neurological health. It also examines the safety and feasibility of using probiotics and postbiotics as adjunct therapies, delving into the mechanisms underlying their beneficial effects. Probiotics and postbiotics demonstrate a capacity to enhance the regenerative potential of the human brain, and recent evaluations provide additional evidence supporting their efficacy and safety. However, further rigorous clinical trials are necessary to validate these findings and establish the most effective therapeutic strategies for treating neurological disorders.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146526
doi: 10.2174/0113892010336767250128072101
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Mohammadpour D
      type: Person
      first name: Darya
      last name: Mohammadpour
      member of: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 2
    item: Asadollahi A
      type: Person
      first name: Afsoon
      last name: Asadollahi
      member of: Department of Maxillofacial Medicine, Faculty of Dentistry, Urmia University of Medical Sciences, Urmia, Iran.
  slot:
    index: 3
    item: Ozma MA
      type: Person
      first name: Mahdi Asghari
      last name: Ozma
      member of: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 4
    item: Mehramuz B
      type: Person
      first name: Bahareh
      last name: Mehramuz
      member of: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 5
    item: Ganbarov K
      type: Person
      first name: Khudaverdi
      last name: Ganbarov
      member of: Research Laboratory of Microbiology and Virology, Baku State University, Baku, Azerbaijan.
  slot:
    index: 6
    item: Kafil HS
      type: Person
      first name: Hossein Samadi
      last name: Kafil
      member of: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-10;():.

In silico Study of Antiviral Phytochemicals for the Potential Drug Development Against Wild-type and Omicron Variants of SARS-CoV-2.
pmid: 39950273
abstract: To identify potential phytochemical-based drugs for both wild-type and Omicron variants of SARS-CoV-2 using virtual screening and molecular dynamic simulation.Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by SARS-CoV-2. Since 2019, multiple variants have been reported from all over the world and the emergence of new variants of SARS-CoV-2 is a major concern.To identify potential phytochemicals that can be used as drugs against different variants of SARS-CoV-2.In our present study, we have selected 594 phytochemicals and performed virtual screening to identify potential drug candidates. The screening commenced with molecular docking techniques with both ACE2 (Human) and Spike protein (wild-type and Omicron variant), followed by prediction of pharmacokinetics parameters and toxicity. The Schrodinger tools, Swiss ADME, and ProTox-II accomplish the analysis. Further, molecular dynamics simulation, binding free energy calculation and meta-dynamics study was performed for best protein-ligand complexes of both proteins using GROMACS and gmx_MMPBSA to validate the stability of the docked complexes.we have identified 6 and 4 drugs as spike protein inhibitors for wild-type and Omicron variants, respectively. 6 drugs were identified as ACE2 receptor inhibitors. We have identified silymarin as a common drug inhibitor for both pathogen (Wild-type, and Omicrons spikes) as well as host (human ACE2) protein that reflects its ability to inhibit the host-pathogen interaction and prevent infection.We have found some potential Phytochemicals that can be used against different variants of SARS-CoV-2 such as silymarin.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPB-EPUB-146504
doi: 10.2174/0113892010251819241120050831
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Dutta S
      type: Person
      first name: Somenath
      last name: Dutta
      member of: Department of Bioinformatics, Pondicherry Central University, Puducherry, India.Birla Institute of Scientific Research, Jaipur India.School of Chemical and Biomolecular Engineering, Pusan National University, Busan, South Korea.
  slot:
    index: 2
    item: Sri Pushan S
      type: Person
      first name: Shilpa
      last name: Sri Pushan
      member of: Department of Bioinformatics, Pondicherry Central University, Puducherry, India.
  slot:
    index: 3
    item: Ghosh R
      type: Person
      first name: Rohan
      last name: Ghosh
      member of: Department of Bioinformatics, Pondicherry Central University, Puducherry, India.Birla Institute of Scientific Research, Jaipur India.
  slot:
    index: 4
    item: Jose M
      type: Person
      first name: Maria
      last name: Jose
      member of: Department of Bioinformatics, Pondicherry Central University, Puducherry, India.
  slot:
    index: 5
    item: Pritam M
      type: Person
      first name: Manisha
      last name: Pritam
      member of: Birla Institute of Scientific Research, Jaipur India.Amity Institute of Biotechnology, Amity University Lucknow campus, India.National Institute of Allergy and Infectious Diseases (NIAID), NIH, MD, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1873-4316
has issn l: 1389-2010
has NLM journal title abbreviation: Curr Pharm Biotechnol
publication name: Current pharmaceutical biotechnology
language: eng
has national library of medicine journal id: 100960530
derived from: NLM
has place of publication: Netherlands
source: Curr Pharm Biotechnol. 2025-02-10;():.

Therapeutic Potential of Mesenchymal Stem Cells or their Secretome in Diabetic Mice with or without Preconditioning Treatment.
pmid: 39950288
abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with difficult management, affecting the quality of life. Stem cell therapy has been proven to have regenerative ability. Using the existing stem cell therapy and modifying it, the current study aims to evaluate the effect of umbilical cord-derived mesenchymal stem cells (UCMSC), condition media (CM), and UCMSC and CM preconditioned with methotrexate, reservetrol, and vitamin D for its ability to manage T1DM in Swiss albino mice.Disease condition was established in the animals by using a diabetesinducing agent streptozotocin (STZ). Then the animals were grouped into normal control, disease control, standard, and test groups; and the treatments were given accordingly. The total study period for this experiment was 28 days. During this period, the animals were supervised for blood glucose levels, food-water intake, and body weight twice a week. At the end of 28 days, the biochemical estimations for serum insulin level, C-peptide, pro-inflammatory cytokines, and anti-inflammatory cytokines level were done. Also, histopathology of the pancreas was performed.The test groups showed a significant decline in the blood glucose level, an increase in C-peptide level, and a decrease in pro-inflammatory cytokines as compared to the disease group. A statistically significant change was not observed within the groups in terms of serum insulin and anti-inflammatory cytokine levels. There were improvements in diabetic symptoms in treatment groups, such as polyphagia, polydipsia, and weight loss. Treatment groups also showed pancreatic regeneration, indicating improved insulin secretion.In the present study, we concluded that UCMSC, CM, and UCMSC and CM preconditioned with synthetic and natural immunosuppressants and immunomodulators have the ability to regenerate damaged pancreatic beta cells and have an antidiabetic activity, along with an immunomodulating effect. This therapy is a promising choice for future research.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: RAIAD-EPUB-146498
doi: 10.2174/0127722708323777250121224618
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Desai SM
      type: Person
      first name: Shivani M
      last name: Desai
      member of: Clinical Research and Pharmacovigilance, Serum Institute of India Pvt. Ltd., Hadapsar, Pune, India.
  slot:
    index: 2
    item: Bhonde RR
      type: Person
      first name: Ramesh R
      last name: Bhonde
      member of: Director Research, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
  slot:
    index: 3
    item: Veeranjaneyulu A
      type: Person
      first name: Addepalli
      last name: Veeranjaneyulu
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
  slot:
    index: 4
    item: Sanap A
      type: Person
      first name: Avinash
      last name: Sanap
      member of: Regenerative Medicine Laboratory, Dr. D. Y. Patil Dental College and Hospital, Pimpri, Pune, India.
  slot:
    index: 5
    item: Jarare S
      type: Person
      first name: Surabhi
      last name: Jarare
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
  slot:
    index: 6
    item: Satpute S
      type: Person
      first name: Snehal
      last name: Satpute
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
  slot:
    index: 7
    item: Janjire O
      type: Person
      first name: Omkar
      last name: Janjire
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
  slot:
    index: 8
    item: Soundankar A
      type: Person
      first name: Anusaya
      last name: Soundankar
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
  slot:
    index: 9
    item: Ahmed N
      type: Person
      first name: Niyaz
      last name: Ahmed
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
  slot:
    index: 10
    item: Abhale K
      type: Person
      first name: Krushna
      last name: Abhale
      member of: Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 2772-2716
has issn l: 2772-2708
has NLM journal title abbreviation: Recent Adv Inflamm Allergy Drug Discov
publication name: Recent advances in inflammation & allergy drug discovery
language: eng
has national library of medicine journal id: 101776469
derived from: NLM
has place of publication: Netherlands
source: Recent Adv Inflamm Allergy Drug Discov. 2025-02-07;():.

Advances in Neuromorphic Computing Devices: Insights on Both Conventional and Unconventional Architectures.
pmid: 39950274
abstract: Neuromorphic circuits and devices have been introduced in the last decades as elements of a key strategy for developing of new paradigms of computation, inspired by the intent to mimic elementary neuron structure and biological mechanisms, for the overcoming of energy and timeconsuming bottlenecks achieved by digital computing (DC) technologies. Although the term neuromorphic is in common use, its meaning is often misunderstood and indistinctly associated with many different technologies, based on both conventional and unconventional electronic components and architectures. Here an overview of the different technological strategies used for developing neuromorphic computing systems is proposed, with an insight on the neuromorphic features they implement and a special focus on the technological strategies and patents that exploit unconventional computing paradigms.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: NANOTEC-EPUB-146551
doi: 10.2174/0118722105335459241210043513
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Decastri D
      type: Person
      first name: Davide
      last name: Decastri
      member of: Dipartimento di Fisica Aldo Pontremoli and CIMaINa, Università degli Studi di Milano, Italy.
  slot:
    index: 2
    item: Borghi F
      type: Person
      first name: Francesca
      last name: Borghi
      member of: Dipartimento di Fisica Aldo Pontremoli and CIMaINa, Università degli Studi di Milano, Italy.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 2212-4020
has issn l: 1872-2105
has NLM journal title abbreviation: Recent Pat Nanotechnol
publication name: Recent patents on nanotechnology
language: eng
has national library of medicine journal id: 101291922
derived from: NLM
has place of publication: United Arab Emirates
source: Recent Pat Nanotechnol. 2025-02-10;():.

The Conjugation of Chlorambucil with 4-Phenylbutanoic Acid and Valproic Acid respectively for Enhancing Anti-tumor Activity.
pmid: 39950290
abstract: Nitrogen mustards exert their anticancer activity by alkylating DNA. However, except for alkylating DNA, nitrogen mustards may alkylate other bio-molecules to cause off-target effects due to their highly active functional groups. So, more exposure of DNA from chromosomes can facilitate the binding of nitrogen mustards to DNA to present stronger anticancer activity, simultaneously avoiding more side effects.To design and synthesize the 4-phenylbutanoic acid-chlorambucil conjugates and valproic acid-chlorambucil conjugates. Upon cellular internalization, the two conju-gates can more strongly damage the DNA of cancer cells due to the more exposure of cel-lular DNA caused by 4-phenylbutanoic acid or valproic acid.To validate this hypothesis, we designed and synthesized two hybrids of chlo-rambucil with 4-phenylbutanoic acid and valproic acid, denoted as compound 2a and compound 2b respectively. The antitumor activity of the aforementioned hybrids was evaluated by the MTT method, mitochondrial membrane potential analysis, apoptosis as-say, DNA damage assay, and scratch assay respectively.Compound 2a and compound 2b were synthesized via esterification. The results of bioactivity evaluation showed compound 2a and compound 2b had stronger cytotoxici-ty against breast cancer MDA-MB-231 cells and MCF-7 cells than chlorambucil. More importantly, toward triple negative breast cancer MDA-MB-231 cells, compound 2a ex-hibited significantly greater cytotoxicity compared to both compound 2b and chlorambu-cil. Further studies were conducted on MDA-MB-231 cells, showing that compound 2a could more strongly decrease the mitochondrial membrane potential, induce cell apopto-sis, and damage cellular DNA compared to compound 2b and chlorambucil. Interestingly, in combating the migration of MDA-MB-231 cells, the results exhibited that compound 2b had a much stronger anti-migratory effect than compound 2a, inconsistent with the aforementioned in vitro cytotoxicity.These findings demonstrate [cell cut: 2144 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: COS-EPUB-146059
doi: 10.2174/0115701794351301241217074232
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Dai Y
      type: Person
      first name: Yi
      last name: Dai
      member of: College of Pharmaceutical Science, Anhui Xinhua University, Hefei 230088, China.
  slot:
    index: 2
    item: Zhang Y
      type: Person
      first name: Yang
      last name: Zhang
      member of: The First Affiliated Hospital of The University of Science and Technology of China, Hefei, 230031, China.
  slot:
    index: 3
    item: Wang X
      type: Person
      first name: Xiangxiang
      last name: Wang
      member of: College of Pharmaceutical Science, Anhui Xinhua University, Hefei 230088, China.
  slot:
    index: 4
    item: Zhang Y
      type: Person
      first name: Yupei
      last name: Zhang
      member of: College of Pharmaceutical Science, Anhui Xinhua University, Hefei 230088, China.
  slot:
    index: 5
    item: Bai J
      type: Person
      first name: Juan
      last name: Bai
      member of: College of Pharmaceutical Science, Anhui Xinhua University, Hefei 230088, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
ISSN: 1570-1794
has issn l: 1570-1794
has NLM journal title abbreviation: Curr Org Synth
publication name: Current organic synthesis
language: eng
has national library of medicine journal id: 101208457
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Org Synth. 2025-02-07;():.

Ameliorating Paraquat-Induced Nephrotoxicity in Rats: Protective Effects of Nanocurcumin on Renal Histology and Molecular Pathways.
pmid: 39950282
abstract: Paraquat (PQ) is a common herbicide, and its mortality results from injury to several organs, including the kidneys. Nanocurcumin and curcumin have anti-inflammatory and anti-oxidative activities, but their involvement in PQ-induced kidney damage is unclear. Therefore, the goal of our study was to compare nanocurcumin and curcumin in male rats whose kidneys were damaged by PQ.42 eight-week male albino Wistar rats were put into six groups at random as control, control + curcumin, control + nanocurcumin, PQ, PQ + curcumin, PQ + nanocurcumin for 7 days. The kidney tissues and serum were collected at the end of this period. Total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol Molecule (TTM), urea, creatinine, and blood urea nitrogen (BUN) levels were assessed. The histopathological evaluation of kidney damage was performed at the end of our study. Moreover, the gene expression was assessed by biochemical and Reverse transcription polymerase chain reaction (RT-PCR) analysis.Curcumin and nanocurcumin administration alleviated PQ-induced renal injury, as evidenced by reduced serum creatinine and BUN levels. The levels of antioxidant markers, like TAC and TTM, increased and decreased the levels of oxidative stress indexes like LPO. Furthermore, our result shows up-regulating the expression of nuclear factor-like 2 (Nrf2), NAD (P) H: quinine oxidoreductase 1 (NQO1), Heme oxygenase 1 (HO-1), and down-regulating the expression of Kelchlike ECH-associated protein 1 (Keap-1) in renal tissue.Niosomal curcumin was more advantageous than ordinary curcumin in lowering oxidative stress and renal tissue damage induced by paraquat intoxication.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: PNT-EPUB-146525
doi: 10.2174/0122117385361582250112083125
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Moghaddam DA
      type: Person
      first name: Davood Ahmadi
      last name: Moghaddam
      member of: Toxicology and Pharmacology Department, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
  slot:
    index: 2
    item: Rahimi M
      type: Person
      first name: Mehdi
      last name: Rahimi
      member of: Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
  slot:
    index: 3
    item: Kheiripour N
      type: Person
      first name: Nejat
      last name: Kheiripour
      member of: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
  slot:
    index: 4
    item: Sadeghian Z
      type: Person
      first name: Zohre
      last name: Sadeghian
      member of: Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  slot:
    index: 5
    item: Asl SS
      type: Person
      first name: Sara Soleymani
      last name: Asl
      member of: Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  slot:
    index: 6
    item: Azizi Z
      type: Person
      first name: Zahra
      last name: Azizi
      member of: Toxicology and Pharmacology Department, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
  slot:
    index: 7
    item: Ranjbar A
      type: Person
      first name: Akram
      last name: Ranjbar
      member of: Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.Medical Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 2211-7393
has issn l: 2211-7385
has NLM journal title abbreviation: Pharm Nanotechnol
publication name: Pharmaceutical nanotechnology
language: eng
has national library of medicine journal id: 101623431
derived from: NLM
has place of publication: United Arab Emirates
source: Pharm Nanotechnol. 2025-02-10;():.

An Emerging Prospective of Antipsychotics for Treating Neurodegenerative Disorders.
pmid: 39950283
abstract: CNS illnesses specified by slow deprivation of especially preganglionic neurons, as opposed to the selective static neuronal loss caused by a toxic or metabolic condition, are known as Neurodegenerative disorders. Neurodegenerative disorders are differentiated clinically by behavioral or cognitive problems. The management and treatment of neurodegenerative disorders pose significant challenges, necessitating a multidimensional approach. While primarily designed for psychiatric conditions, antipsychotics have shown potential in ameliorating behavioral and psychological symptoms in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. This review explores the existing literature, highlighting the potential benefits, risks, and considerations associated with incorporating antipsychotics into the treatment paradigm for neurodegenerative disorders. Additionally, it discusses the evolving landscape of personalized treatment strategies, emphasizing the need for a multidisciplinary approach to optimize patient outcomes in the complex realm of neurodegenerative disorder management.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146491
doi: 10.2174/0113816128344910241211112452
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Kumar B
      type: Person
      first name: Bhavna
      last name: Kumar
      member of: Faculty of Pharmacy DIT University, Dehradun 248009, Uttarakhand, India.
  slot:
    index: 2
    item: Sahoo A
      type: Person
      first name: Arpita
      last name: Sahoo
      member of: Faculty of Pharmacy DIT University, Dehradun 248009, Uttarakhand, India.
  slot:
    index: 3
    item: Singhal M
      type: Person
      first name: Manmohan
      last name: Singhal
      member of: Faculty of Pharmacy DIT University, Dehradun 248009, Uttarakhand, India.
  slot:
    index: 4
    item: Varshney G
      type: Person
      first name: Garima
      last name: Varshney
      member of: Faculty of Pharmacy DIT University, Dehradun 248009, Uttarakhand, India.
  slot:
    index: 5
    item: Haldar T
      type: Person
      first name: Tripti
      last name: Haldar
      member of: Faculty of Pharmacy DIT University, Dehradun 248009, Uttarakhand, India.
  slot:
    index: 6
    item: Bali V
      type: Person
      first name: Vikas
      last name: Bali
      member of: Manager in IPR Kusum Healthcare Private Limited, New Delhi, India.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-07;():.

A Bibliometric Analysis on Urticaria: Roles of Oxidative Stress, Inflammation, Immunity, and Treatment Modalities.
pmid: 39950289
abstract: This study provides a comprehensive bibliometric analysis of global research on urticaria, aiming to chart its progression, assess its relevance, and explore the roles of oxidative stress, inflammation, and immunity in its pathogenesis. Additionally, by analyzing data from PubMed and Scopus, we mapped research trends, identified leading authors and institutions, and examined global collaboration patterns. We also evaluated the impact of oxidative stress, inflammation, and immunity on urticaria and assessed the roles of both conventional and traditional medicine in its management. The results highlight the evolution of urticaria research, key contributors, thematic developments, and collaborative networks. This study offers a detailed bibliometric profile and thematic map, including insights into effective authors, prominent keywords, and significant research patterns. The findings are valuable for medical researchers, providing an updated overview of current themes and gaps, and are also beneficial for healthcare decision-makers by summarizing relevant information for strategic planning and fostering new collaborations. Additionally, the study integrates biological aspects related to urticaria with insights into traditional treatments, contributing to both research and practical management strategies.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: RAIAD-EPUB-146499
doi: 10.2174/0127722708352247250121110712
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Zeeshan HM
      type: Person
      first name: Hafiz Muhammad
      last name: Zeeshan
      member of: Department of Computer Science, National College of Business Administration & Economics, Lahore, Pakistan.
  slot:
    index: 2
    item: Bin Heyat MB
      type: Person
      first name: Md Belal
      last name: Bin Heyat
      member of: Westlake University, Hangzhou, China.
  slot:
    index: 3
    item: Sultana A
      type: Person
      first name: Arshiya
      last name: Sultana
      member of: National Institute of Unani Medicine, Ministry of AYUSH, Govt. of India, Bengaluru, Karnataka, India.
  slot:
    index: 4
    item: Bin Hayat MA
      type: Person
      first name: Mohd Ammar
      last name: Bin Hayat
      member of: College of Intelligent Systems Science and Engineering, Harbin Engineering University, Harbin, China.
  slot:
    index: 5
    item: Sayeed E
      type: Person
      first name: Eram
      last name: Sayeed
      member of: Jamia Hamdard, India.
  slot:
    index: 6
    item: Akhtar F
      type: Person
      first name: Faijan
      last name: Akhtar
      member of: University of Electronic Science and Technology of China, China.
  slot:
    index: 7
    item: Benkmil N
      type: Person
      first name: Nouhayla
      last name: Benkmil
      member of: Southwest Petroleum University, Chengdu, China.
  slot:
    index: 8
    item: Abbasi R
      type: Person
      first name: Rashid
      last name: Abbasi
      member of: College of Computer Science and Artificial Intelligence, Wenzhou University, Wenzhou 325035, China.
  slot:
    index: 9
    item: Abdelgeliel AS
      type: Person
      first name: Asmaa Sayed
      last name: Abdelgeliel
      member of: Botany & Microbiology Department, South Valley University, Qena 83523, Egypt.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
e ISSN: 2772-2716
has issn l: 2772-2708
has NLM journal title abbreviation: Recent Adv Inflamm Allergy Drug Discov
publication name: Recent advances in inflammation & allergy drug discovery
language: eng
has national library of medicine journal id: 101776469
derived from: NLM
has place of publication: Netherlands
source: Recent Adv Inflamm Allergy Drug Discov. 2025-02-07;():.

Exploring Neighborhood Topological Descriptors for Quantitative Structure-property Relationship (QSPR) Analysis and Entropy Measures of Some Anti-cancer Drugs.
pmid: 39950293
abstract: This study investigated many cancer medicines using a wide range of degree sum-based topological indices and entropy. These numerical numbers, commonly referred to as topological indices or molecular descriptors, depict a substance's molecular structure. They have been successfully used to properly reflect different physicochemical properties in a number of Quantitative Structure-Property Relationship (QSPR) and Quanti-tative Structure-Activity Relationship (QSAR) research studies.The purpose of the study was to investigate the relationships between topological neighborhood indices and physicochemical properties using the QSPR model and linear re-gression methodology.We employed linear regression methodology within the QSPR model to examine the connections between physicochemical characteristics and topological neighborhood in-dices.The results revealed a significant correlation between the neighborhood indices un-der scrutiny and the physicochemical features of the potential drugs under investigation.As a result, both neighborhood topological indices and entropy demonstrate potential as valuable tools for future QSPR investigations when evaluating anticancer medi-cations.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: COS-EPUB-146546
doi: 10.2174/0115701794349166241217085334
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Augustine T
      type: Person
      first name: Tony
      last name: Augustine
      member of: Viswajyothi College of Engineering and Technology, Department of Science and Humanities.
  slot:
    index: 2
    item: Santiago R
      type: Person
      first name: Roy
      last name: Santiago
      member of: Vellore Institute of Technology University, School of Advanced Sciences, Department of Mathematics.
  slot:
    index: 3
    item: Jeyaraj SV
      type: Person
      first name: Sahaya Vijay
      last name: Jeyaraj
      member of: Vellore Institute of Technology University, School of Advanced Sciences, Department of Mathematics.
  slot:
    index: 4
    item: Azeem M
      type: Person
      first name: Mohamad
      last name: Azeem
      member of: University of Manchester, Department of Solids and Structures, School of Engineering.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
ISSN: 1570-1794
has issn l: 1570-1794
has NLM journal title abbreviation: Curr Org Synth
publication name: Current organic synthesis
language: eng
has national library of medicine journal id: 101208457
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Org Synth. 2025-02-10;():.

Therapeutic Effects and Mechanisms of Icaritin in Parkinson's Disease.
pmid: 39950284
abstract: Parkinson's Disease (PD) is a neurodegenerative disorder of the central nervous system (CNS). Given the increasing age of the general population, PD has emerged as a significant public health and societal concern, impacting both individual well-being and socioeconomic progress. The present interventions have proven insufficient in impeding the progressive nature of PD. Consequently, it is imperative to promptly identify efficacious strategies for the prevention and treatment of PD. Icaritin (ICT) is a flavonoid extracted from Epimedium Brevicornu Maxim that is a phytoestrogen with antitumour, anti-inflammatory, antioxidant, antiaging, and neuroprotective properties. This paper reviews the protective effect of ICT on dopaminergic neurons through anti-oxidative stress, improving mitochondrial function, inhibiting neuroinflammatory responses, reducing Lewy body formation, and decreasing apoptosis. The primary objective of this article is to provide valuable insights and serve as a reference for the potential use of ICT in the prevention and treatment of PD.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146516
doi: 10.2174/0113816128344629250115074105
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zheng C
      type: Person
      first name: Chongbo
      last name: Zheng
      member of: Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, Gannan Medical University, Ganzhou 341000, China.First Clinical Medical School of Gannan Medical University, Ganzhou 341000, China.
  slot:
    index: 2
    item: Wu L
      type: Person
      first name: Lizhen
      last name: Wu
      member of: Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, Gannan Medical University, Ganzhou 341000, China.Department of Physiology, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou, 341000, China.
  slot:
    index: 3
    item: Luo L
      type: Person
      first name: Liang
      last name: Luo
      member of: Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, Gannan Medical University, Ganzhou 341000, China.First Clinical Medical School of Gannan Medical University, Ganzhou 341000, China.
  slot:
    index: 4
    item: Cai J
      type: Person
      first name: Jiating
      last name: Cai
      member of: Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, Gannan Medical University, Ganzhou 341000, China.First Clinical Medical School of Gannan Medical University, Ganzhou 341000, China.
  slot:
    index: 5
    item: Huang Z
      type: Person
      first name: Zhihua
      last name: Huang
      member of: Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, Gannan Medical University, Ganzhou 341000, China.Department of Physiology, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou, 341000, China.
  slot:
    index: 6
    item: Tian K
      type: Person
      first name: Keqiang
      last name: Tian
      member of: Department of Head and Neck Surgery, Ganzhou Cancer Hospital, Gannan Medical University, Ganzhou, 341000, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-10;():.

A Valuable Target for Therapy: The Metalloproteinase ADAM10.
pmid: 39950287
abstract: A special kind of posttranslational process known as proteolytic cleavage controls the half-lives and functions of several extracellular and intracellular proteins. The metalloproteinase ADAM10 has attracted attention because it cleaves a growing amount of protein substrates close to the extracellular membrane leaflet. The process known as ectodomain shedding controls the turnover of certain transmembrane proteins that are essential for receptor signaling and cell adhesion. It may trigger nuclear transport, intramembrane proteolysis, and cytoplasmic domain signaling. Additional human illnesses linked to ADAM10 include cancer, immune system malfunction, and neurodegeneration. The difficulty in targeting proteases for medicinal reasons stems from the many substrates that these enzymes, particularly ADAM10, have. It is usually necessary to precisely identify the therapeutic beneficial window of use since blocking or accelerating a particular protease activity is linked with undesirable side effects. More knowledge of the regulatory pathways governing ADAM10 expression, subcellular localization, and activity will probably lead to the identification of viable therapeutic targets, enabling more targeted and precise manipulation of the enzyme's proteolytic activity.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPPS-EPUB-146530
doi: 10.2174/0113892037348066250117070824
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Tripathi S
      type: Person
      first name: Siddhant
      last name: Tripathi
      member of: Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pharm chemistry, Pune, Maharashtra, 411038, India.
  slot:
    index: 2
    item: Sharma Y
      type: Person
      first name: Yashika
      last name: Sharma
      member of: Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pharm chemistry, Pune, Maharashtra, 411038, India.
  slot:
    index: 3
    item: Kumar D
      type: Person
      first name: Dileep
      last name: Kumar
      member of: Department of Pharm Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1875-5550
has issn l: 1389-2037
has NLM journal title abbreviation: Curr Protein Pept Sci
publication name: Current protein & peptide science
language: eng
has national library of medicine journal id: 100960529
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Protein Pept Sci. 2025-02-10;():.

Treatment Outcomes in Granular Parakeratosis: A Systematic Review.
pmid: 39950301
doi: 10.1177/12034754251316536
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Geng RSQ
      type: Person
      first name: Ryan S Q
      last name: Geng
      member of: Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  slot:
    index: 2
    item: Sood S
      type: Person
      first name: Siddhartha
      last name: Sood
      member of: Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
  slot:
    index: 3
    item: Waked J
      type: Person
      first name: Jihad
      last name: Waked
      member of: Faculty of Medicine, Western University, London, ON, Canada.
  slot:
    index: 4
    item: Towheed S
      type: Person
      first name: Shahnawaz
      last name: Towheed
      member of: Faculty of Medicine, McMaster University, Hamilton, ON, Canada.
  slot:
    index: 5
    item: Merchant N
      type: Person
      first name: Nabil
      last name: Merchant
      member of: Royal College of Surgeons in Ireland, Dublin, Ireland.
  slot:
    index: 6
    item: Abduelmula A
      type: Person
      first name: Abrahim
      last name: Abduelmula
      member of: Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  slot:
    index: 7
    item: Yeung J
      type: Person
      first name: Jensen
      last name: Yeung
      member of: Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.Department of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.Department of Dermatology, Women's College Hospital, Toronto, ON, Canada.Probity Medical Research, Waterloo, ON, Canada.
  slot:
    index: 8
    item: Mufti A
      type: Person
      first name: Asfandyar
      last name: Mufti
      member of: Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.Department of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:02
e ISSN: 1615-7109
has issn l: 1203-4754
has NLM journal title abbreviation: J Cutan Med Surg
publication name: Journal of cutaneous medicine and surgery
language: eng
has national library of medicine journal id: 9614685
derived from: NLM
pg: 12034754251316536
has place of publication: United States
source: J Cutan Med Surg. 2025-02-14;():12034754251316536.

Nanotechnology-based Approaches for Targeted Drug Delivery to the Small Intestine: Advancements and Challenges.
pmid: 39950285
abstract: Nanotechnology has emerged as a promising avenue for targeted drug delivery to the small intestine, offering precise control over drug release and enhanced therapeutic efficacy. This review discusses recent advancements and challenges in nanotechnology-based approaches for targeted drug delivery to the small intestine. The small intestine presents unique challenges for drug delivery, including enzymatic degradation, low permeability, and rapid transit time. Nanotechnology offers solutions to these challenges by providing carriers capable of protecting drugs from degradation, enhancing their absorption, and facilitating site-specific delivery. Various nanocarrier systems have been explored for targeted drug delivery to the small intestine, including liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles. These carriers can be functionalized with ligands targeting specific receptors or transporters expressed on the intestinal epithelium, enabling efficient uptake and intracellular delivery of drugs. Additionally, nanotechnology enables the controlled release of drugs, allowing for sustained and/or triggered release profiles tailored to the physiological conditions of the small intestine. This precise control over drug release can improve therapeutic outcomes while minimizing systemic side effects. Despite the significant progress in nanotechnology-based drug delivery to the small intestine, several challenges remain. These include achieving sufficient drug loading capacity, ensuring biocompatibility and safety of nanocarriers, and addressing regulatory concerns associated with their clinical translation. In conclusion, nanotechnology holds immense potential for targeted drug delivery to the small intestine, offering solutions to overcome the limitations of conventional drug delivery systems. Addressing the remaining challenges will be crucial for realizing the full therapeutic benefits of nanotechnology in treating diseases affecting the small i[cell cut: 2009 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146517
doi: 10.2174/0113816128347722250109042022
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Chandra P
      type: Person
      first name: Phool
      last name: Chandra
      member of: Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
  slot:
    index: 2
    item: Ruhela M
      type: Person
      first name: Manav
      last name: Ruhela
      member of: Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
  slot:
    index: 3
    item: Kumar P
      type: Person
      first name: Prashant
      last name: Kumar
      member of: Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
  slot:
    index: 4
    item: Porwal M
      type: Person
      first name: Mayur
      last name: Porwal
      member of: Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
  slot:
    index: 5
    item: Verma A
      type: Person
      first name: Anurag
      last name: Verma
      member of: Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
  slot:
    index: 6
    item: Sharma H
      type: Person
      first name: Himanshu
      last name: Sharma
      member of: Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
  slot:
    index: 7
    item: Sachan N
      type: Person
      first name: Neetu
      last name: Sachan
      member of: Pharmaceutical Chemistry, Maharana Pratap College of Pharmacy, Uttar P radesh, India.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-10;():.

Recent Advances in Co-Condensation and Co-Aggregation of Amyloid Proteins Linked to Neurodegenerative Diseases.
pmid: 39950286
abstract: The misfolding and aggregation of amyloid proteins are closely associated with a range of neurodegenerative diseases. Liquid-liquid phase separation (LLPS) can initiate the aggregation of proteins, indicating that LLPS may serve as an alternative pathway for the pathological aggregation of amyloid proteins. The co-occurrence of two or more amyloid pathologies has been observed in extensive pathophysiological studies and is linked to faster disease progression. The co- LLPS (also known as co-condensation) and co-aggregation of different disease-related proteins have been proposed as a potential molecular mechanism for combined neuropathology. Here, we reviewed the current state of knowledge regarding the co-aggregation and co-condensation of various amyloid proteins, including Aβ, tau, α-synuclein, TDP-43, FUS, and hnRNPA/B protein family, C9orf72 dipeptide repeats and prion protein. We briefly introduced the epidemiological correlation among different neurodegenerative diseases and specifically presented recent experimental findings about co-aggregation and co-condensation of two different amyloid proteins. Additionally, we discussed computational studies focusing on the molecular interactions between amyloid proteins to offer mechanistic insights into the co-LLPS and co-aggregation processes. This review provides an overview of the synergistic interactions between different disease-related proteins, which is helpful for understanding the mechanisms of combined neuropathology and developing targeted therapeutic strategies.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPPS-EPUB-146547
doi: 10.2174/0113892037350729241129054701
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Zhang X
      type: Person
      first name: Xuefeng
      last name: Zhang
      member of: Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory of Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai200438, China.
  slot:
    index: 2
    item: Chen Y
      type: Person
      first name: Yujie
      last name: Chen
      member of: Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory of Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai200438, China.
  slot:
    index: 3
    item: Tan Y
      type: Person
      first name: Yuan
      last name: Tan
      member of: Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory of Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai200438, China.
  slot:
    index: 4
    item: Pan T
      type: Person
      first name: Tong
      last name: Pan
      member of: Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory of Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai200438, China.
  slot:
    index: 5
    item: Wei G
      type: Person
      first name: Guanghong
      last name: Wei
      member of: Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory of Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai200438, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 1875-5550
has issn l: 1389-2037
has NLM journal title abbreviation: Curr Protein Pept Sci
publication name: Current protein & peptide science
language: eng
has national library of medicine journal id: 100960529
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Protein Pept Sci. 2025-02-10;():.

Advances in Sources, Content Determination, and Bioactivity of 20α-Hydroxyprogesterone.
pmid: 39950296
abstract: 20α-hydroxyprogesterone [(20S)-20-hydroxypregn-4-en-3-one, 20α-DHP] is one of the endogenous metabolites of progesterone (Pregn-4-ene-3,20-dione, P4) and a steroid hormone. The literature related to 20α-DHP mainly concentrates on the years from the 1950s to 1970s, and a review of 20α-DHP has not been conducted. In this work, the endogenous and exogenous sources of 20α-DHP are introduced, and methods for determining 20α-DHP in biological samples are described. The biological activities of 20α-DHP are summarized in detail, including the maintenance of pregnancy, endometrial protection, regulation of hormone secretion, ovulation promotion, uterine epithelial cell proliferation, antagonism of breast cancer, and as a diagnostic indicator for psoriasis and polycystic ovarian syndrome. Finally, the pharmacokinetic characteristics of 20α- DHP are briefly introduced to provide a reference for the further development and utilization of 20α-DHP.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: EMIDDT-EPUB-146507
doi: 10.2174/0118715303302957250117052100
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Li L
      type: Person
      first name: Liangyun
      last name: Li
      member of: College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China.
  slot:
    index: 2
    item: Yan S
      type: Person
      first name: Shujing
      last name: Yan
      member of: College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China.
  slot:
    index: 3
    item: Cheng Y
      type: Person
      first name: Yuexuan
      last name: Cheng
      member of: College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China.
  slot:
    index: 4
    item: Zhong C
      type: Person
      first name: Chunhong
      last name: Zhong
      member of: College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China.
  slot:
    index: 5
    item: Chen C
      type: Person
      first name: Chunli
      last name: Chen
      member of: College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China.Engineering Research Center of Xinjiang and Central Asian Medicine Resources, Ministry of Education, Urumqi, Xinjiang, 830017, China.Xinjiang Key Laboratory of Active Components and Drug Release Technology of Natural Drugs, Urumqi, Xinjiang, 830017, China.Xinjiang Key Laboratory of Active Components and Drug Release Technology of Natural Drugs, Urumqi, Xinjiang, 830017, China.
  slot:
    index: 6
    item: Gao X
      type: Person
      first name: Xiaoli
      last name: Gao
      member of: College of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, 830017, China.Engineering Research Center of Xinjiang and Central Asian Medicine Resources, Ministry of Education, Urumqi, Xinjiang, 830017, China.Xinjiang Key Laboratory of Active Components and Drug Release Technology of Natural Drugs, Urumqi, Xinjiang, 830017, China.Xinjiang Key Laboratory of Active Components and Drug Release Technology of Natural Drugs, Urumqi, Xinjiang, 830017, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 2212-3873
has issn l: 1871-5303
has NLM journal title abbreviation: Endocr Metab Immune Disord Drug Targets
publication name: Endocrine, metabolic & immune disorders drug targets
language: eng
has national library of medicine journal id: 101269157
derived from: NLM
has place of publication: United Arab Emirates
source: Endocr Metab Immune Disord Drug Targets. 2025-02-10;():.

Sars-Cov-2 Infection as Catecholamin Crisis in Pheocreomocitoma: A Case Report.
pmid: 39950294
abstract: The primary presentation of SARS-CoV-2 infection is viral pneumonia, which may be complicated by acute respiratory distress syndrome, although several other manifestations can occur.. Endocrine implications have been described. Pheochromocytomas are rare tumors mainly originating in the adrenal medulla. Symptoms are primarily due to catecholamine overproduction and abrupt release. Catecholamine release is unregulated and could be continuous or paroxysmal. Some conditions (i.e., stress, physical exercise, or specific foods) can trigger catecholamine release. Sars-CoV-2 infections have not been previously described as precipitators of adrenergic crises in pheochromocytoma patients. In this study, we report a case of adrenal crisis of a patient affected by pheochromocytoma in the context of Sars-CoV-2 infection.A 63-year-old Caucasian male known for right adrenal pheochromocytoma waiting for surgical removal was admitted to the Emergency Department (ED) in March 2021 for a fainting episode and hypertensive crisis that he never experienced before. The patient had a known medical history of type 2 mellitus diabetes and hypercholesterolemia treated by slow-release metformin 500 mg/day and atorvastatin 40 mg/day and was not vaccinated for Sars-CoV-2. Two months before, the patient was hospitalized in another hospital for myocardial infarction with non-obstructive coronary arteries, and a chest-abdomen TC scan showed a right adrenal lodge occupied by coarse formation. In the 24-h urine sample, metanephrines were >5000 μg/24h and Normetanephrines >2500 μg/24h. Scintigraphy with 123I-Metaiodobenzylguanidine (MIBG) showed accumulation in right adrenal gland formation, confirming the suspicion of pheochromocytoma. No further areas of pathological uptake were present. Fort that, the patient was started on alpha-blockers (doxazosin 2 mg twice/day). Two weeks later, the patient was also prescribed metoprolol 50 mg twice/day. When admitted to the Emergency Department (ED), Blood Pr[cell cut: 3115 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: EMIDDT-EPUB-146505
doi: 10.2174/0118715303348376250103113426
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Novizio R
      type: Person
      first name: Roberto
      last name: Novizio
      member of: Unit of Endocrinology and Diabetology, Catholic University of The Sacred Heart, Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  slot:
    index: 2
    item: Corsello A
      type: Person
      first name: Andrea
      last name: Corsello
      member of: Unit of Endocrinology, Ospedale Fatebenefratelli Gemelli Isola, Rome, Italy.
  slot:
    index: 3
    item: Rizzo GE
      type: Person
      first name: Gaetano Emanuele
      last name: Rizzo
      member of: Unit of Endocrinology, Metabolism and Nutrition, Ospedale Paolo Borsellino.
  slot:
    index: 4
    item: Pontecorvi A
      type: Person
      first name: Alfredo
      last name: Pontecorvi
      member of: Unit of Endocrinology and Diabetology, Catholic University of The Sacred Heart, Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  slot:
    index: 5
    item: Locantore P
      type: Person
      first name: Pietro
      last name: Locantore
      member of: Unit of Endocrinology and Diabetology, Catholic University of The Sacred Heart, Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 2212-3873
has issn l: 1871-5303
has NLM journal title abbreviation: Endocr Metab Immune Disord Drug Targets
publication name: Endocrine, metabolic & immune disorders drug targets
language: eng
has national library of medicine journal id: 101269157
derived from: NLM
has place of publication: United Arab Emirates
source: Endocr Metab Immune Disord Drug Targets. 2025-02-10;():.

ICPi-Induced Graves' Disease with Pre-existing Autoimmune Thyroid Disorders: A Case Report and Literature Review.
pmid: 39950295
abstract: Immune Checkpoint Inhibitor (ICPi) therapy has revolutionized cancer treatment but can lead to immune-related adverse events (irAE), including thyroid dysfunction. The impact of ICPi on patients with pre-existing autoimmune thyroid diseases (PATD), particularly the development of Graves' disease, remains poorly understood.We provide the first complete case of Graves' disease with ICPi therapy in a patient who already had Hashimoto's thyroiditis.. The patient, a 52-year-old male, was diagnosed with lung adenocarcinoma and received Atezolizumab. Clinical evaluation revealed hyperthyroidism, confirmed by elevated thyroid hormones and autoantibodies (TRAb and TSAb). The patient was managed with methimazole and demonstrated a transient hyperthyroid phase followed by persistent hypothyroidism. Only 16 confirmed cases of Graves' disease induced by ICPi were reported. We conducted a review to investigate the clinical characteristics, risk factors, and prognosis trends associated with ICPi-induced Graves disease in PTAD patients. Additionally, changes in thyroid function and autoantibodies during and after ICPi treatment are examined.This case underscores the importance of monitoring thyroid function and autoantibodies in patients with PATD undergoing ICPi therapy. The findings suggest distinct differences in the humoral immune response between ICPi-induced and spontaneous Graves' disease, necessitating further research into autoantibody dynamics and their relationship with cellular immunity in these patients.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: EMIDDT-EPUB-146506
doi: 10.2174/0118715303317264250116095028
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Wang X
      type: Person
      first name: Xinpan
      last name: Wang
      member of: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
  slot:
    index: 2
    item: Chen D
      type: Person
      first name: Doudou
      last name: Chen
      member of: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
  slot:
    index: 3
    item: Shi Y
      type: Person
      first name: Yun
      last name: Shi
      member of: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
  slot:
    index: 4
    item: Yang T
      type: Person
      first name: Tao
      last name: Yang
      member of: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
  slot:
    index: 5
    item: Zheng X
      type: Person
      first name: Xuqin
      last name: Zheng
      member of: Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing, China.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T04:53
e ISSN: 2212-3873
has issn l: 1871-5303
has NLM journal title abbreviation: Endocr Metab Immune Disord Drug Targets
publication name: Endocrine, metabolic & immune disorders drug targets
language: eng
has national library of medicine journal id: 101269157
derived from: NLM
has place of publication: United Arab Emirates
source: Endocr Metab Immune Disord Drug Targets. 2025-02-10;():.

Design, Synthesis, and Biological Evaluation of Some Novel o-aminophenol Derivatives.
pmid: 39950292
abstract: o-Aminophenol derivatives are of particular interest for their di-verse biological activities and potential therapeutic applications. Such as, antioxidant, an-tibacterial, and cytotoxic activities.This study aimed to design and synthesize a series of novel o-aminophenol de-rivatives through an efficient multi-step process, characterize them using modern spectro-scopic techniques, and evaluate their antimicrobial, antioxidant, and cytotoxic activities.A series of novel derivatives of o-aminophenol have been successfully synthe-sized with very high efficiency through a simple six-step process using readily available chemicals and straightforward reactions. The structures of all products were accurately de-termined using modern spectroscopic methods such as 1D and 2D NMR, as well as IR, MS spectroscopy, and X-ray methods. The antimicrobial activities of eight o-nitrophenol derivatives were assessed against Gram (-) and Gram (+) bacteria as well as fungi. In comparison, antioxidant activities were tested for two o-nitrophenol and 11 o-aminophenol derivatives using SC50 and EC50 assays. Cytotoxicity was evaluated on KB, HepG2, A549, and MCF7 cancer cell lines.Six synthesized compounds 5b, 5c, 5g, 6b, 6c, 6g exhibited unusual doublet sig-nals in the H8 region of the 1H NMR spectrum, attributed to atropisomer formation. Eight o-nitrophenol derivatives demonstrated weak antimicrobial activity, with MIC values ranging from 100 to 200 μg/mL. Compound 5g showed activity against all tested bacterial and fungal strains. In antioxidant testing, eight o-aminophenol derivatives 6a, 6b, 6c, 6e, 6f, 6h, 6i, and 12b displayed excellent activity, with SC50 values between 18.95 and 34.26 μg/mL, approaching ascorbic acid's SC50 value of 12.60 μg/mL. Three derivatives 6d, 6g, and 12a showed superior antioxidant activity with EC50 values between 4.00 and 11.25 μg/mL, surpassing quercetin's standard of 9.8 μg/mL. Cytotoxicity assays revealed that o-aminophenol derivatives 6b, 6c, 6f, 6i, an[cell cut: 2453 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: COS-EPUB-146467
doi: 10.2174/0115701794360303250109065121
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Nguyen DV
      type: Person
      first name: Dat Van
      last name: Nguyen
      member of: Department of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
  slot:
    index: 2
    item: Tran LD
      type: Person
      first name: Ly Duou
      last name: Tran
      member of: Department of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
  slot:
    index: 3
    item: Vu PNU
      type: Person
      first name: Phuong Ngoc Uyen
      last name: Vu
      member of: Department of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
  slot:
    index: 4
    item: Meervelt LV
      type: Person
      first name: Luc Van
      last name: Meervelt
      member of: Department of Chemistry, KU Leuven, Celestijnenlaan, 200F, B-3001 Leuven, Belgium.
  slot:
    index: 5
    item: Nguyen MNT
      type: Person
      first name: Mai Ngoc Thi
      last name: Nguyen
      member of: Department of Science, Hong Duc University, Thanh Hoa, Vietnam.
  slot:
    index: 6
    item: Ngo AL
      type: Person
      first name: Anh Lan
      last name: Ngo
      member of: Department of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
  slot:
    index: 7
    item: Duong HQ
      type: Person
      first name: Hoan Quoc
      last name: Duong
      member of: Department of Chemistry, Hanoi National University of Education, Hanoi, Vietnam.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
ISSN: 1570-1794
has issn l: 1570-1794
has NLM journal title abbreviation: Curr Org Synth
publication name: Current organic synthesis
language: eng
has national library of medicine journal id: 101208457
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Org Synth. 2025-02-07;():.

Gender-Specific Cardiovascular Risks in Sleep Apnoea Syndrome: A Call for Precision Medicine.
pmid: 39950299
has PII: 8015359
doi: 10.1093/eurjpc/zwaf077
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Ou YH
      type: Person
      first name: Yi-Hui
      last name: Ou
      member of: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore.
  slot:
    index: 2
    item: Lee CH
      type: Person
      first name: Chi-Hang
      last name: Lee
      member of: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore.Department of Cardiology, National University Heart Centre, Singapore.
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:02
e ISSN: 2047-4881
has issn l: 2047-4873
has NLM journal title abbreviation: Eur J Prev Cardiol
publication name: European journal of preventive cardiology
language: eng
has national library of medicine journal id: 101564430
derived from: NLM
has place of publication: England
source: Eur J Prev Cardiol. 2025-02-14;():.

A Convenient one-pot Approach to the Synthesis of Novel Benzimidazole-Indole Molecular Hybrids as Benzazacamalexin Related Analogues.
pmid: 39950291
abstract: New benzazacamalexin-related analogues are synthesized in an easily accessible one-pot approach. The method is based on the reaction of indoles with in situ formed electrophilic N-alkoxycarbonylbenzimidazolium reagents. For the first time, their application for N-alkylation of the indole nitrogen atom is announced toward novel tris-heterocyclic hybrids. The structure of newly obtained products was spectrally charac-terized by 1D and 2D-NMR, FTIR and HRMS spectral data. The current scientific re-search is based on the application of a convenient and efficient route for the preparation of various benzimidazoles. This approach is both straightforward and economical, utilizing readily accessible and affordable reagents leading to target compounds.The synthesis of novel benzimidazole-indole molecular hybrids as benzazaca-malexin related analogues.A suitable in situ method has been successfully applied, using an α-amidoalkylation reaction of indoles with N,N-diacyliminium reagents derived from ben-zimidazoles and alkyl chloroformates.The reactions led to the obtaining of ten novel compounds (5a-e, 6a-e), including bromine and iodine-containing benzo-analogues on a gram-scale scope and yields ranging from 82% to 99%. For the first time the synthesis of indole tris-heterocycles (7a, b) through the reaction of N-alkylation of the indole nitrogen atom is announced giving an-other potential synthetic application of the N,N-dialkoxycarbonyl-5,6-dimethylbenzimidazolium adducts.The structure of the newly synthesized products is spectrally analysed and proved.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: COS-EPUB-145893
doi: 10.2174/0115701794364219241228094932
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Stremski Y
      type: Person
      first name: Yordan
      last name: Stremski
      member of: Department of Organic Chemistry, University of Plovdiv, 24 Tsar Asen Str., 4000, Plovdiv, Bulgaria.
  slot:
    index: 2
    item: Bachvarova M
      type: Person
      first name: Maria
      last name: Bachvarova
      member of: Department of Organic Chemistry, University of Plovdiv, 24 Tsar Asen Str., 4000, Plovdiv, Bulgaria.
  slot:
    index: 3
    item: Kirkova D
      type: Person
      first name: Desislava
      last name: Kirkova
      member of: Tobacco and Tobacco Products Institute, Agricultural Academy, 4108, Markovo, Sofia, Bulgaria.
  slot:
    index: 4
    item: Milinova E
      type: Person
      first name: Elena
      last name: Milinova
      member of: Department of Organic Chemistry, University of Plovdiv, 24 Tsar Asen Str., 4000, Plovdiv, Bulgaria.
  slot:
    index: 5
    item: Statkova-Abeghe S
      type: Person
      first name: Stela
      last name: Statkova-Abeghe
      member of: Department of Organic Chemistry, University of Plovdiv, 24 Tsar Asen Str., 4000, Plovdiv, Bulgaria.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-07
dp: 2025 Feb 07
created: 2025-2-14T04:53
ISSN: 1570-1794
has issn l: 1570-1794
has NLM journal title abbreviation: Curr Org Synth
publication name: Current organic synthesis
language: eng
has national library of medicine journal id: 101208457
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Org Synth. 2025-02-07;():.

Understanding the Effects of Digital Storytelling on OUD Stigma Reduction: Exploring Character and the Recovery Plot.
pmid: 39950341
abstract: Stigma interferes with all aspects of opioid use disorder (OUD) recovery. One way to reduce public stigma of OUD is through exposure to a type of digital storytelling, in which the public is exposed to outgroup storytellers sharing their experiences with recovery in short videos or narratives posted online. The past two decades have seen an explosion in digital storytelling projects, but we still have much to understand about why exposure to digital stories reduces public stigma. We drew upon theorizing in narrative persuasion, mediated intergroup contact, and character construction to make a predictive model. In addition, we considered how differences in the end of a recovery plot (e.g., abstinence) shape narrative processes and effects. The theorized model and research questions were tested with an experiment (N = 232) informed by a real digital story from the StoryPowered Initiative. The results showed support for the theoretical model: exposure to a digital recovery story reduced negative stereotypes and promoted willingness to have future interactions with people living with OUD via narrative involvement, character fluidity, intergroup anxiety, intergroup ease, and outgroup variability. The results also showed that, compared to other conditions, a recovery plot that included medications for opioid use disorder (MOUDs) then abstinence resulted in stronger perceptions of character fluidity, which, in turn, predicted the mechanisms and outcomes of stigma reduction. We consider the theoretical and practical implications of these results.
doi: 10.1080/10410236.2025.2463535
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Smith RA
      type: Person
      first name: Rachel A
      last name: Smith
      member of: Department of Communication Arts and Sciences, Penn State University.
  slot:
    index: 2
    item: Osoro RA
      type: Person
      first name: Ruth A
      last name: Osoro
      member of: Department of Communication Arts and Sciences, Penn State University.
  slot:
    index: 3
    item: Sterner G
      type: Person
      first name: Glenn
      last name: Sterner
      member of: Department of Criminal Justice, Pennsylvania State University and Founder of The Story Powered Initiative.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:23
e ISSN: 1532-7027
has issn l: 1041-0236
has NLM journal title abbreviation: Health Commun
publication name: Health communication
language: eng
has national library of medicine journal id: 8908762
derived from: NLM
starting page: 1
ending page: 11
has place of publication: England
source: Health Commun. 2025-02-14;():1-11.

Kinematic considerations for achieving the quadruple axel jump: comparison with triple axel jumps among world-class figure skaters using tracking data.
pmid: 39950336
abstract: In figure skating, achieving higher scores often relies on the successful execution of difficult jumps, e.g., quadruple jumps. According to previous biomechanical studies, jump heights do not change significantly even with more rotational jumps. However, strategies employed by top skaters to acquire new jumps are unclear. Therefore, this study aimed to investigate specific kinematic strategies used by skaters to perform the quadruple axel jump (4A), focusing on two skaters (skaters A and B) who attempted this jump in competitions. Using data from the Ice Scope tracking system, this study analysed the vertical height, horizontal distance, take-off speed, landing speed, and height-to-distance ratio of the jumps. Both skaters achieved higher vertical heights in their 4A attempts than in their triple axel jump (3A) attempts. Notably, Skater A's successful 4A and Skater B's downgraded 4A had significantly greater vertical heights than the average 3As among world-class skaters. This suggests a strategic shift towards increasing the vertical height to master 4As, contrary to previous biomechanical research that did not emphasise vertical height. These findings update existing theories on figure skating research and provide insights into training strategies for mastering difficult jumps.
doi: 10.1080/14763141.2025.2464787
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Hirosawa S
      type: Person
      first name: Seiji
      last name: Hirosawa
      member of: Department of Sport and Health Sciences, Toin University of Yokohama, Yokohama, Japan.Institute of Physical Education, Keio University, Yokohama, Japan.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:22
e ISSN: 1752-6116
has issn l: 1476-3141
has NLM journal title abbreviation: Sports Biomech
publication name: Sports biomechanics
language: eng
has national library of medicine journal id: 101151352
derived from: NLM
starting page: 1
ending page: 12
has place of publication: England
source: Sports Biomech. 2025-02-14;():1-12.

Omega-3 and aspirin in the nonsurgical treatment of grade C periodontitis: A randomized clinical trial.
pmid: 39950354
abstract: The use of omega-3 (Ω-3) polyunsaturated fatty acids and acetylsalicylic acid (ASA, aspirin) has shown better clinical outcomes in the treatment of periodontitis compared to nonsurgical periodontal therapy (NSPT) alone. This randomized clinical trial aimed to evaluate the use of 900 mg Ω-3 and 100 mg ASA for 180 days as adjuncts to NSPT for generalized stage III-IV grade C periodontitis (GCP).Patients underwent subgingival debridement (SD) associated with Ω-3+ASA or cellulose placebo and received monthly prophylaxis. Clinical and immunological parameters were compared at baseline, 3, and 6 months after treatment. The daily dose of Ω-3 consisted of 540 mg eicosapentaenoic acid (EPA) and 360 mg docosahexaenoic acid (DHA).Thirty-eight patients, 12 males (7 in the SD+Ω-3+AAS group and 5 in the SD+Placebo group; p > 0.05), with a mean age of 32.84 ± 5.47 and 30.42 ± 5.79 years, respectively (p > 0.05), were included. Both groups showed significant improvements (p < 0.05) in all full-mouth parameters. Reductions in the number of pockets, mean probing depth (PD), and clinical attachment level of moderate and deep sites, as well as the number and percentage of residual pockets, were observed (intragroup p < 0.05; intergroup p > 0.05). However, residual pockets' mean PD decrease (p < 0.05) was only observed at 6 months in the SD+Ω-3+ASA group. The concentration of interleukin (IL)-1β from moderate and deep pockets decreased (p < 0.05) in both groups. The matrix metalloproteinase (MMP)-9 to tissue metalloproteinase inhibitor (TIMP)-1 ratio in the SD+Placebo group at 3 months revealed a proinflammatory profile in moderate (intergroup p = 0.006) and deep pockets (intergroup p < 0.001).Ω-3+ASA therapy did not add clinical benefits to the NSPT for generalized stage III-IV GCP, although some immunomodulatory benefits could be observed.The use of omega-3 (Ω-3) and aspirin (ASA) along with subgingival debridement (SD) for root decontamination of periodontal pockets has shown better [cell cut: 3105 characters, first 2000 kept]
rights: © 2025 American Academy of Periodontology.
doi: 10.1002/JPER.24-0322
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Araujo CF
      type: Person
      first name: Cássia F
      last name: Araujo
      member of: Department of Diagnosis and Surgery, Division of Periodontology, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.Division of Dentistry, Faculdade Santo Antônio, Caçapava, São Paulo, Brazil.
  slot:
    index: 2
    item: Andere NMRB
      type: Person
      first name: Naira M R B
      last name: Andere
      member of: Department of Diagnosis and Surgery, Division of Periodontology, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
  slot:
    index: 3
    item: Castro Dos Santos NC
      type: Person
      first name: Nidia C
      last name: Castro Dos Santos
      member of: Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.
  slot:
    index: 4
    item: Ferraz LFF
      type: Person
      first name: Laís F F
      last name: Ferraz
      member of: Department of Diagnosis and Surgery, Division of Periodontology, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
  slot:
    index: 5
    item: Miguel MMV
      type: Person
      first name: Manuela M V
      last name: Miguel
      member of: Department of Diagnosis and Surgery, Division of Periodontology, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
  slot:
    index: 6
    item: Mathias-Santamaria IF
      type: Person
      first name: Ingrid F
      last name: Mathias-Santamaria
      member of: Department of Oral Health Practice, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 7
    item: Monteiro MF
      type: Person
      first name: Mabelle F
      last name: Monteiro
      member of: Department of Periodontics and Prosthodontics, Division of Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
  slot:
    index: 8
    item: Shaddox LM
      type: Person
      first name: Luciana M
      last name: Shaddox
      member of: Department of Oral Health Practice, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 9
    item: Casarin RCV
      type: Person
      first name: Renato C V
      last name: Casarin
      member of: Department of Periodontics and Prosthodontics, Division of Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
  slot:
    index: 10
    item: Santamaria MP
      type: Person
      first name: Mauro P
      last name: Santamaria
      member of: Department of Diagnosis and Surgery, Division of Periodontology, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.Department of Oral Health Practice, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:43
e ISSN: 1943-3670
has issn l: 0022-3492
has NLM journal title abbreviation: J Periodontol
publication name: Journal of periodontology
language: eng
has national library of medicine journal id: 8000345
derived from: NLM
has place of publication: United States
source: J Periodontol. 2025-02-14;():.

Evaluation of the analgesic effect of a combination of oral acetaminophen and oxycodone after extracorporeal shock wave lithotripsy (SWL).
pmid: 39950358
abstract: The present study aimed to compare the effects of suppository diclofenac (an example of NSAIDs) and oral administration of the combination of oxycodone (an example of an opioid) and acetaminophen in managing pain in patients with renal colic after SWL treatment.The current study is a double-blind clinical trial involving individuals scheduled to receive elective SWL therapy for kidney and ureteral stones. Participants were randomly assigned to one of two groups using the block randomization technique: suppository Diclofenac (100 mg) or a combination of 325 mg Acetaminophen + 5 mg oxycodone administered orally for pain relief following SWL. Pain intensity was measured immediately after the SWL procedure, and analgesics were then given to the patients. After 30 min, pain severity was reassessed. The severity of pain in patients was documented before and after drug administration at 24, 48, and 72 h after the SWL intervention.154 renal stone patients (63 females) underwent SWL with a mean age of 41.52 ± 10.52 years. The two groups were similar in terms of age (p = 0.572), sex (p = 0.212), location of the stone (p = 0.868), size of the stone (p = 0.762), and occurrence of complication (p = 0.302). There was no significant difference in the reduction of pain severity between the two groups after 30 min (p = 0.224), 2 days (p = 0.501), and 3 days (p = 0.229) following SWL intervention. However, after a 24-h follow-up, pain severity decreased more in the diclofenac group compared to the other group (p = 0.002).The combination of oxycodone and acetaminophen, including a multimodal analgesic approach, can be considered a preferred option in the clinical setting for pain management of patients undergoing SWL. It provides relief for patients as effectively as NSAIDs, with the same safety profile, leading to high patient satisfaction.
doi: 10.1177/03915603251317046
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zareian Baghdadabad L
      type: Person
      first name: Leila
      last name: Zareian Baghdadabad
      member of: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Mohammadi A
      type: Person
      first name: Abdolreza
      last name: Mohammadi
      member of: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Menbari Oskouie I
      type: Person
      first name: Iman
      last name: Menbari Oskouie
      member of: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 4
    item: Alaeddini F
      type: Person
      first name: Farshid
      last name: Alaeddini
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 5
    item: Farajidavar H
      type: Person
      first name: Hirad
      last name: Farajidavar
      member of: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Pharmacy, Tehran, Iran.
  slot:
    index: 6
    item: Oliveira Reis L
      type: Person
      first name: Leonardo
      last name: Oliveira Reis
      member of: UroScience and Department of Surgery (Urology), School of Medical Sciences, University of Campinas, Unicamp, and Pontifical Catholic University of Campinas, PUC-Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 7
    item: Aghamir SMK
      type: Person
      first name: Seyed Mohammad Kazem
      last name: Aghamir
      member of: Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:43
e ISSN: 1724-6075
has issn l: 0391-5603
has NLM journal title abbreviation: Urologia
publication name: Urologia
language: eng
has national library of medicine journal id: 0417372
derived from: NLM
pg: 3915603251317046
has place of publication: United States
source: Urologia. 2025-02-14;():3915603251317046.

Risk of Post-polypectomy Bleeding After Colorectal Endoscopic Mucosal Resection in Patients With Cirrhosis: A Propensity-Matched Analysis of the US Collaborative Network.
pmid: 39950371
abstract: Data on the risk of post-polypectomy bleeding after endoscopic mucosal resection (EMR) in patients with cirrhosis are limited.This retrospective cohort study used the US Collaborative Network to assess post-polypectomy bleeding risk after colorectal EMR in patients with cirrhosis compared with controls. Using one-to-one propensity score matching, the primary outcome measured was bleeding within 30 days post-EMR. The bleeding risk was further stratified by cirrhosis severity (compensated and decompensated).After propensity score matching, each cohort included 2,381 patients. Patients with cirrhosis had a higher risk of post-polypectomy bleeding (odds ratio [OR] 1.38, 95% confidence interval [CI] 1.05-1.82, P = 0.02). However, endoscopic reinterventions for hemostasis were similar between cirrhosis and control cohorts (OR 1.20, 95% CI 0.71-2.05, P = 0.50). The post-polypectomy bleeding risk was significantly higher in patients with decompensated cirrhosis (OR 1.65, 95% CI 1.12-2.42, P = 0.01), while those with compensated cirrhosis showed no increased risk of post-polypectomy bleeding (OR 1.15, 95% CI 0.85-1.54, P = 0.37).The post-polypectomy bleeding risk was higher in patients with decompensated cirrhosis, while the bleeding risk was not increased in those with compensated disease. Optimizing patients with cirrhosis, especially with decompensated disease, before colorectal EMR and monitoring for post-procedure bleeding remain important. A conservative, supportive approach to managing bleeding in patients with cirrhosis may be as effective as in those without cirrhosis.
rights: Copyright © 2025 by The American College of Gastroenterology.
has PII: 00000434-990000000-01552
doi: 10.14309/ajg.0000000000003322
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Beran A
      type: Person
      first name: Azizullah
      last name: Beran
      member of: Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 2
    item: Elfert K
      type: Person
      first name: Khaled
      last name: Elfert
      member of: Division of Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
  slot:
    index: 3
    item: Patel FN
      type: Person
      first name: Feenalie N
      last name: Patel
      member of: Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Houston, Texas, USA.
  slot:
    index: 4
    item: Mohamed M
      type: Person
      first name: Mouhand
      last name: Mohamed
      member of: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 5
    item: Ramai D
      type: Person
      first name: Daryl
      last name: Ramai
      member of: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 6
    item: Canakis A
      type: Person
      first name: Andrew
      last name: Canakis
      member of: Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 7
    item: Thakkar S
      type: Person
      first name: Shyam
      last name: Thakkar
      member of: Division of Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
  slot:
    index: 8
    item: Rex DK
      type: Person
      first name: Douglas K
      last name: Rex
      member of: Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 9
    item: Bhavsar-Burke I
      type: Person
      first name: Indira
      last name: Bhavsar-Burke
      member of: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, USA; and.Department of Learning Health Science, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  slot:
    index: 10
    item: Guardiola JJ
      type: Person
      first name: John J
      last name: Guardiola
      member of: Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01-16
dp: 2025 Jan 16
created: 2025-2-14T05:53
e ISSN: 1572-0241
has issn l: 0002-9270
has NLM journal title abbreviation: Am J Gastroenterol
publication name: The American journal of gastroenterology
language: eng
has national library of medicine journal id: 0421030
derived from: NLM
has place of publication: United States
source: Am J Gastroenterol. 2025-01-16;():.

The power of the smile.
pmid: 39950381
has PII: 5938223
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Stefanini M
      type: Person
      first name: Martina
      last name: Stefanini
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:53
ISSN: 2198-591X
issue: 1
has NLM journal title abbreviation: Int J Esthet Dent
publication name: The international journal of esthetic dentistry
language: eng
has national library of medicine journal id: 101624416
derived from: NLM
starting page: 7
ending page: 8
has place of publication: Germany
source: Int J Esthet Dent. 2025-02-14;20(1):7-8.
volume: 20

Resin-bonded bridge.
pmid: 39950382
has PII: 5938224
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Štefanatný M
      type: Person
      first name: Michal
      last name: Štefanatný
  slot:
    index: 2
    item: Dírer P
      type: Person
      first name: Peter
      last name: Dírer
  slot:
    index: 3
    item: Belák Š
      type: Person
      first name: Šimon
      last name: Belák
  slot:
    index: 4
    item: Štefanatná J
      type: Person
      first name: Jana
      last name: Štefanatná
  slot:
    index: 5
    item: Kriška P
      type: Person
      first name: Peter
      last name: Kriška
created: 2025-2-14T06:21
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:53
ISSN: 2198-591X
issue: 1
has NLM journal title abbreviation: Int J Esthet Dent
publication name: The international journal of esthetic dentistry
language: eng
has national library of medicine journal id: 101624416
derived from: NLM
starting page: 10
ending page: 11
has place of publication: Germany
source: Int J Esthet Dent. 2025-02-14;20(1):10-11.
volume: 20

Identifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort.
pmid: 39950372
abstract: Although metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD with increased alcohol intake (MetALD) are identified as clinical entities; tools to identify patients from electronic health records (EHRs) to perform large outcome studies are lacking.In this retrospective study of participants from the Veterans Analysis of Liver Disease cohort assembled from 1/1/2013 to 12/31/2022, a rule-based natural language processing (NLP) algorithm searched EHRs for imaging evidence of hepatic steatosis. This was combined with identification of cardiometabolic risk factors and harmful alcohol use. Algorithm-derived diagnoses of MASLD, MetALD, alcohol-associated steatotic liver disease (ALD), and no steatotic liver disease (SLD) were validated using a blinded review of randomly selected charts.Among 817,657 eligible veterans, SLD was present in over half (n = 438,209, 53.5%), including MASLD in 299,259 (36.5%), 99,163 with MetALD (12.1%), and 38,552 (4.7%) with ALD. The NLP algorithm had a high correlation with steatosis on chart review, with a κ of 0.86 (95% CI 0.82-0.90), sensitivity of 0.96, and specificity of 0.90. Classification of MASLD, MetALD, ALD, and no SLD by the algorithm also showed high correlation with chart review, with a κ of 0.87 (95% CI 0.82-0.91). This algorithm identified 299,259 (36.5%) of the study cohort with MASLD, compared with 23,218 patients (2.8%) identified using International Classification of Diseases-9/10 codes.An algorithm combining rule-based NLP with cardiometabolic risk factors and alcohol use from EHRs accurately identifies and classifies SLD and can be applied in large epidemiologic studies of SLD in the Veterans Health Administration.
rights: Copyright © 2025 by The American College of Gastroenterology.
has PII: 00000434-990000000-01551
doi: 10.14309/ajg.0000000000003321
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: John BV
      type: Person
      first name: Binu V
      last name: John
      member of: Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.Division of Gastroenterology and Hepatology, Miami VA Medical System, Miami, Florida, USA.
  slot:
    index: 2
    item: Bastaich D
      type: Person
      first name: Dustin
      last name: Bastaich
      member of: Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA.Central Virginia VA Health System, Richmond, Virginia, USA.
  slot:
    index: 3
    item: Mezzacappa C
      type: Person
      first name: Catherine
      last name: Mezzacappa
      member of: Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.VA Connecticut Healthcare System, West Haven, Connecticut, USA.
  slot:
    index: 4
    item: Ferreira RD
      type: Person
      first name: Raphaella D
      last name: Ferreira
      member of: Division of Gastroenterology and Hepatology, Miami VA Medical System, Miami, Florida, USA.Department of Internal Medicine, Larkin Community Hospital, Miami, Florida, USA.
  slot:
    index: 5
    item: Hentschel A
      type: Person
      first name: Austen
      last name: Hentschel
      member of: Division of Gastroenterology and Hepatology, Miami VA Medical System, Miami, Florida, USA.Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
  slot:
    index: 6
    item: Samos A
      type: Person
      first name: Andres
      last name: Samos
      member of: Division of Gastroenterology and Hepatology, Miami VA Medical System, Miami, Florida, USA.Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
  slot:
    index: 7
    item: Mahmud N
      type: Person
      first name: Nadim
      last name: Mahmud
      member of: Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
  slot:
    index: 8
    item: Taddei TH
      type: Person
      first name: Tamar H
      last name: Taddei
      member of: Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.VA Connecticut Healthcare System, West Haven, Connecticut, USA.
  slot:
    index: 9
    item: Kaplan D
      type: Person
      first name: David
      last name: Kaplan
      member of: Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
  slot:
    index: 10
    item: Serper M
      type: Person
      first name: Marina
      last name: Serper
      member of: Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
  slot:
    index: 11
    item: Dahman B
      type: Person
      first name: Bassam
      last name: Dahman
      member of: Central Virginia VA Health System, Richmond, Virginia, USA.Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, Virginia, USA.
creator: Veterans Analysis of Liver Disease (VALID) group of investigators
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-01-16
dp: 2025 Jan 16
created: 2025-2-14T05:53
e ISSN: 1572-0241
has issn l: 0002-9270
has NLM journal title abbreviation: Am J Gastroenterol
publication name: The American journal of gastroenterology
language: eng
has national library of medicine journal id: 0421030
derived from: NLM
has place of publication: United States
source: Am J Gastroenterol. 2025-01-16;():.

A Multi-Omics Meta-Analysis of Rhizosphere Microbiome Reveals Growth-Promoting Marker Bacteria at Different Stages of Legume Development.
pmid: 39950378
abstract: Plant-microbe interactions have been studied extensively in legumes, but the influence of host developmental stages on its microbiome remains poorly understood. The rhizospheric region enriched with microbial diversity presents an optimal environment to investigate this relationship. We employed a multi-omics meta-analysis approach to identify the rhizospheric bacteria co-existing with legumes at different developmental stages. The data from eight different legume species across various geographical locations, soil conditions and developmental stages (vegetative, reproductive and maturation) were included in the study. A total of 10 developmental stage-specific marker bacteria were identified and found to be positively associated with plant growth phenotypes. The functional profiling elucidated the expression of these marker bacterial genes, indicating the active presence of marker bacteria. Co-expression network analysis revealed the involvement of gene clusters in biological processes such as cobalt and nitrogen metabolism. Further, pathway enrichment analysis illustrated the role of these bacteria in plant metabolic pathways, such as biosynthesis of various plant secondary metabolites, biotin metabolism and carbon fixation in photosynthetic organisms. Our study identified a positive relationship between marker bacteria and the host plant, suggesting their crucial role in legume growth and development that could further aid in crop improvement strategies.
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1111/pce.15429
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sahil R
      type: Person
      first name: Rishav
      last name: Sahil
      member of: Translational Genomics and Systems Biology Laboratory, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
  slot:
    index: 2
    item: Pal V
      type: Person
      first name: Vivek
      last name: Pal
      member of: Translational Genomics and Systems Biology Laboratory, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
  slot:
    index: 3
    item: Kharat AS
      type: Person
      first name: Arun S
      last name: Kharat
      member of: Laboratory of Applied Microbiology and Cancer Remedies, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
  slot:
    index: 4
    item: Jain M
      type: Person
      first name: Mukesh
      last name: Jain
      member of: Translational Genomics and Systems Biology Laboratory, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:53
e ISSN: 1365-3040
has issn l: 0140-7791
has NLM journal title abbreviation: Plant Cell Environ
publication name: Plant, cell & environment
language: eng
has national library of medicine journal id: 9309004
derived from: NLM
has place of publication: United States
source: Plant Cell Environ. 2025-02-14;():.

Marine endo tooth.
pmid: 39950389
has PII: 5938231
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Serrano T
      type: Person
      first name: Toño
      last name: Serrano
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:53
ISSN: 2198-591X
issue: 1
has NLM journal title abbreviation: Int J Esthet Dent
publication name: The international journal of esthetic dentistry
language: eng
has national library of medicine journal id: 101624416
derived from: NLM
pg: 93
has place of publication: Germany
source: Int J Esthet Dent. 2025-02-14;20(1):93.
volume: 20

Selective etching options.
pmid: 39950388
has PII: 5938230
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Mancuso E
      type: Person
      first name: Edoardo
      last name: Mancuso
created: 2025-2-14T06:20
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T05:53
ISSN: 2198-591X
issue: 1
has NLM journal title abbreviation: Int J Esthet Dent
publication name: The international journal of esthetic dentistry
language: eng
has national library of medicine journal id: 101624416
derived from: NLM
pg: 92
has place of publication: Germany
source: Int J Esthet Dent. 2025-02-14;20(1):92.
volume: 20

Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host.
pmid: 39950400
abstract: Maintaining stable drug concentrations in the bloodstream is a challenge for injectable hydrophobic progestin contraceptives. This work investigates porous silicon dioxide (pSiO2) microparticles as a delivery vehicle for progestins via melt-infiltration of drugs into the mesopores. The pSiO2 is prepared through electrochemical anodization of single-crystalline silicon followed by thermal oxidation, yielding vertically oriented pores (≈50 nm diameter) with porosity varied (between 35-75%) to optimize drug loading and release. Among the progestins tested, etonogestrel and levonorgestrel (LNG) decompose near their melting points, preventing melt infiltration. However, addition of 20% cholesterol by mass suppresses the melting point of LNG sufficiently to enable loading without degradation. Mass loadings exceeding 50% (drug: drug + carrier) are achieved for segesterone acetate (SEG) and LNG, retaining drug crystallinity as confirmed by X-ray diffraction. In vitro, both SEG and LNG-loaded pSiO2 display sustained drug release for up to 3 months, with reduced burst release, more constant steady-state concentrations, and a substantially reduced tail compared to pure LNG or SEG, or SEG loaded into pSiO2 from a chloroform solution. In a pilot in vivo study, SEG-loaded pSiO2 microparticles are well tolerated in 20-week-old female rats over a 25-week period, with no signs of toxicity.
rights: © 2025 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.
doi: 10.1002/adhm.202403802
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Hollett G
      type: Person
      first name: Geoffrey
      last name: Hollett
      member of: Materials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 2
    item: Fan R
      type: Person
      first name: Ruhan
      last name: Fan
      member of: Materials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 3
    item: Kumeria T
      type: Person
      first name: Tushar
      last name: Kumeria
      member of: School of Materials Science and Engineering, University of New South Wales, Kensington, Sydney, NSW, 2052, Australia.
  slot:
    index: 4
    item: Leonard H
      type: Person
      first name: Heidi
      last name: Leonard
      member of: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 5
    item: Kim B
      type: Person
      first name: Byungji
      last name: Kim
      member of: Materials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 6
    item: Martin TR
      type: Person
      first name: Taylor R
      last name: Martin
      member of: Chien-Lay Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 7
    item: Ipekci I
      type: Person
      first name: Irmak
      last name: Ipekci
      member of: Chien-Lay Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 8
    item: Wang J
      type: Person
      first name: Joanna
      last name: Wang
      member of: Materials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 9
    item: Byun J
      type: Person
      first name: Jiuk
      last name: Byun
      member of: Materials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 10
    item: Chan NA
      type: Person
      first name: Nicole A
      last name: Chan
      member of: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 11
    item: Pierron A
      type: Person
      first name: Amber
      last name: Pierron
      member of: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  slot:
    index: 12
    item: Moore CE
      type: Person
      first name: Curtis E
      last name: Moore
      member of: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43214, USA.
  slot:
    index: 13
    item: Ayres J
      type: Person
      first name: Jennifer
      last name: Ayres
      member of: Contraceptive Research, Development, and Introduction, FHI 360 359 Blackwell Street, #200, Durham, NC, 27701, USA.
  slot:
    index: 14
    item: Sailor MJ
      type: Person
      first name: Michael J
      last name: Sailor
      member of: Materials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:03
e ISSN: 2192-2659
has issn l: 2192-2640
has NLM journal title abbreviation: Adv Healthc Mater
publication name: Advanced healthcare materials
language: eng
has national library of medicine journal id: 101581613
derived from: NLM
pg: e2403802
has place of publication: Germany
source: Adv Healthc Mater. 2025-02-14;():e2403802.

A Systematic Review and Meta-Analysis of the Efficacy and Safety of Limus-Coated/Eluting Devices in Peripheral Arterial Disease.
pmid: 39950413
abstract: Limus-based balloons, stents, and scaffolds are alternatives to paclitaxel-coated devices in peripheral endovascular treatment. This study aims to review contemporary evidence on the efficacy and safety of limus-coated devices in the treatment of lower extremity peripheral arterial disease (PAD).A systematic literature review was performed using PubMed, Web of Sciences, OvidSP, and EMBASE, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Efficacy endpoints were primary patency (PP), freedom from clinically driven target lesion revascularization (CD-TLR) and Rutherford-Becker improvement; safety endpoints included target limb amputation and all-cause mortality.From a primary search of 453 articles between 27th June 2002 to 15th September 2024, 30 publications, among which were 27 prospective trials, 10 multicenter studies and 11 double-arm studies, with 2325 patients were analyzed. The numbers for above-the-knee (ATK) limus-balloons, stents, scaffolds and below-the-knee (BTK) limus-balloons, stents, scaffolds were 76, 333, 35, 55, 1445, 381 respectively. With a mean 12-month follow-up, PP for ATK lesions was 86.50% for sirolimus-coated balloons (SCB), 86.80% for sirolimus-eluting stents (SES), 72.60% for everolimus-eluting stents (EES), 86.20% for everolimus bioresorbable vascular scaffold (EBVS); whereas PP for BTK lesions was 72.60%, 73.20%, 71.60 and 83.80% respectively. Absence of CD TLR for ATK lesions was 96.50%, 95.50%, 87.60%, 89.20% respectively; meanwhile 84.90%, 75.80%, 87.70%, 94.30% for BTK lesions respectively. Rutherford-Becker improvement with 86.70%, 84.50%, 79.80 and 90.80% were seen in ATK lesions respectively, similarly, 76.50%, 81.90%, 79.50%, 92.30% respectively were observed in BTK lesions. Efficacy and clinical outcomes of SES, EES and EBVS in BTK lesions were significantly superior, where vascular complications had no proven significant difference regardless of lesion locations nor device typ[cell cut: 3109 characters, first 2000 kept]
doi: 10.1177/15266028251315442
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mok MKY
      type: Person
      first name: Michelle Kam Yan
      last name: Mok
      member of: Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  slot:
    index: 2
    item: Wu IHC
      type: Person
      first name: Iris Ho Ching
      last name: Wu
      member of: Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  slot:
    index: 3
    item: Yau KHK
      type: Person
      first name: Kenneth Hong Kit
      last name: Yau
      member of: Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  slot:
    index: 4
    item: Chan YC
      type: Person
      first name: Yiu Che
      last name: Chan
      member of: Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.Division of Vascular & Endovascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Hong Kong SAR, China.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:12
e ISSN: 1545-1550
has issn l: 1526-6028
has NLM journal title abbreviation: J Endovasc Ther
publication name: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
language: eng
has national library of medicine journal id: 100896915
derived from: NLM
pg: 15266028251315442
has place of publication: United States
source: J Endovasc Ther. 2025-02-14;():15266028251315442.

Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications.
pmid: 39950424
abstract: Porous scaffolds in bone tissue engineering (BTE) play a crucial role in facilitating osteointegration with host tissues and providing nutrients to cells involved in bone healing. Scaffold architecture influences osteointegration, biofunctionality and mechanical strength, necessitating a clear understanding of its impact. In this study, hydroxyapatite scaffolds are 3D printed with three types of triply periodic minimal surface (TPMS) structures: gyroid, lidinoid, and split-P, at porosities ranging from 50% to 80%. Split-P architecture exhibits the highest compression strength, between 15 and 25 MPa, but provides the least surface area for bone apatite precipitation. Conversely, gyroid and lidinoid structures demonstrate the highest levels of bone apatite precipitation across all porosities when immersed in simulated body fluid. To optimise scaffold design, graded structures were designed with multiple TPMS structures arranged in a core-shell configuration. A structure featuring a solid core and a 70% gyroid shell achieves the highest compression strength of 120 MPa, while also supporting cell attachment and differentiation comparable to that of a fully porous structure. This combination of compression strength similar to cancellous bone and ability for positive interaction with osteoblast cells makes it an ideal candidate for load-bearing applications in BTE.
rights: © 2025 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.
doi: 10.1002/adhm.202402953
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Koushik TM
      type: Person
      first name: Tejas M
      last name: Koushik
      member of: College of Science and Engineering, James Cook University, Townsville, QLD, 4811, Australia.
  slot:
    index: 2
    item: Miller CM
      type: Person
      first name: Catherine M
      last name: Miller
      member of: College of Medicine and Dentistry, James Cook University, Cairns, QLD, 4878, Australia.
  slot:
    index: 3
    item: Antunes E
      type: Person
      first name: Elsa
      last name: Antunes
      member of: College of Science and Engineering, James Cook University, Townsville, QLD, 4811, Australia.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:13
e ISSN: 2192-2659
has issn l: 2192-2640
has NLM journal title abbreviation: Adv Healthc Mater
publication name: Advanced healthcare materials
language: eng
has national library of medicine journal id: 101581613
derived from: NLM
pg: e2402953
has place of publication: Germany
source: Adv Healthc Mater. 2025-02-14;():e2402953.

Advances in Machine Learning Models for Healthcare Applications: A Precise and Patient-Centric Approach.
pmid: 39950456
abstract: Healthcare is rapidly leveraging machine learning to enhance patient care, streamline operations, and address complex medical issues. Though ethical issues, model efficiency, and algorithmic bias exist, the COVID-19 pandemic highlighted its usefulness in disease outbreak prediction and treatment optimization.This article aims to discuss machine learning applications, benefits, and the ethical and practical challenges in healthcare.Machine learning assists in diagnosis, patient monitoring, and epidemic prediction but faces challenges like algorithmic bias and data quality. Overcoming these requires high-quality data, impartial algorithms, and model monitoring.Machine learning might revolutionize healthcare by making it more efficient and better for patients. Full acceptance and the advancement of technologies to improve health outcomes on a global scale depend on resolving ethical, practical, and technological concerns.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146602
doi: 10.2174/0113816128353371250119121315
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Parashar B
      type: Person
      first name: Bhumika
      last name: Parashar
      member of: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
  slot:
    index: 2
    item: Sridhar SB
      type: Person
      first name: Sathvik Belagodu
      last name: Sridhar
      member of: RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.
  slot:
    index: 3
    item: Kalpana
      type: Person
      last name: Kalpana
      member of: School of Pharmaceutical Sciences, Chhatrapati Shahu Ji Maharaj University, Kanpur, India.
  slot:
    index: 4
    item: Malviya R
      type: Person
      first name: Rishabha
      last name: Malviya
      member of: Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
  slot:
    index: 5
    item: Prajapati BG
      type: Person
      first name: Bhupendra G
      last name: Prajapati
      member of: Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, India.
  slot:
    index: 6
    item: Uniyal P
      type: Person
      first name: Prerna
      last name: Uniyal
      member of: School of Pharmacy, Graphic Era Hill University, Dehradun, India.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-11;():.

Cytokine and Oxidative Stress Imbalances in Relation to Complex Coronary Lesions in Elderly Patients.
pmid: 39950452
abstract: Complex coronary lesions have been an understudied aspect of coronary artery disease in elderly patients. Oxidative stress and inflammation may be implicated in the pathogenesis of complex coronary lesions.The aim of this study is to investigate the complex interplay between pro-oxidative stress response, pro-inflammatory response, and complex coronary lesions in elderly patients.Enzyme-linked immunosorbent assays for the detection of serum biomarkers [reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), superoxide dismutase (SOD) activity, total antioxidant capacity (TAC), transforming growth factor beta (TGF-β) and interleukin-4 (IL-4)] were performed in elderly patients with complex coronary lesions.The levels of pro-oxidative stress and pro-inflammatory markers (ROS, MDA, TNF-α and IFN-γ) were increased in the complex coronary lesion group when compared with the non-complex coronary lesion group (P < 0.01) in elderly patients. Anti-oxidative stress and anti-inflammatory markers (SOD activity, TAC, TGF-β, and IL-4) were decreased in the complex coronary lesion group when compared with the non-complex coronary lesion group (P < 0.01) in elderly patients.Our findings suggest that the pathogenesis of complex coronary lesions may involve pro-oxidant/anti-oxidant and pro-inflammation/anti-inflammation imbalance, as well as the interplay between oxidative stress and inflammation in elderly patients.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CVP-EPUB-146584
doi: 10.2174/0115701611323165250211045917
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Li X
      type: Person
      first name: Xia
      last name: Li
      member of: Xiamen Road Branch Hospital, The Second People's Hospital of Huai'an, Jiangsu Province, Huaian 223005, China.
  slot:
    index: 2
    item: Zhao Y
      type: Person
      first name: Yongjuan
      last name: Zhao
      member of: Xiamen Road Branch Hospital, The Second People's Hospital of Huai'an, Jiangsu Province, Huaian 223005, China.
  slot:
    index: 3
    item: Zhou H
      type: Person
      first name: Hualan
      last name: Zhou
      member of: Department of Geriatrics, The Second People's Hospital of Huai'an, Jiangsu Province, Huaian 223002, China.
  slot:
    index: 4
    item: Hu Y
      type: Person
      first name: Youdong
      last name: Hu
      member of: Department of Geriatrics, The Second People's Hospital of Huai'an, Jiangsu Province, Huaian 223002, China.
  slot:
    index: 5
    item: Chen Y
      type: Person
      first name: Ying
      last name: Chen
      member of: Department of Geriatrics, The Second People's Hospital of Huai'an, Jiangsu Province, Huaian 223002, China.
  slot:
    index: 6
    item: Guo D
      type: Person
      first name: Dianxuan
      last name: Guo
      member of: Xiamen Road Branch Hospital, The Second People's Hospital of Huai'an, Jiangsu Province, Huaian 223005, China.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1875-6212
has issn l: 1570-1611
has NLM journal title abbreviation: Curr Vasc Pharmacol
publication name: Current vascular pharmacology
language: eng
has national library of medicine journal id: 101157208
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Vasc Pharmacol. 2025-02-11;():.

Teachers Burnout Affective and Motivational Profiles: Their Impact on Teachers' Stress, Anxiety and Depression Levels.
pmid: 39950442
abstract: The study aims at investigating teachers' burnout, motivational and affective profiles. Moreover, the study explores differences in stress, anxiety and depression levels among teachers' profiles. The sample comprised of 816 participants who completed the following scales: (a) Maslach Burnout Inventory-Educators Survey , (b) Passion Scale , (c) Positive and Negative Affect scale and (d) DASS-21. A clustering approach through latent profile analysis revealed four teachers' profiles: 1. Workaholics (18.25%), 2. Moderate Burnout (28.67%), 3. Normal Workers (42.15%) and 4. Extreme Burnout (10.90%). The study also revealed differences between the profiles in terms of teachers' stress, anxiety and depression levels. The third profile (Normal Workers) showed the lowest levels in all three variables, followed by the first profile (Workaholics). The second profile (Moderate Burnout) showed relatively high levels and the fourth profile (Extreme Burnout) the highest stress, anxiety and depression levels. Through multinomial logistic regression, discriminant analysis and the decision tree, depression and stress emerged as predictive/differentiating factors for the inclusion of participants in the profiles, with an accuracy around 55%. The distinction between teachers profiles' will facilitate the recognition of teachers already experiencing burnout or at high risk (Extreme and Moderate Burnout profiles), so that they receive first-line therapeutic interventions while teachers belonging to the more adaptive profiles (Workaholics and Normal Workers) could benefit more from prevention-oriented programs. These programs can be utilized by school psychologists and policy makers in school contexts aiming at reducing dysphoric burnout emotions on a therapeutic level and raising awareness informing and psychoeducating on a preventive level.
doi: 10.1177/00332941251320026
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Kamtsios S
      type: Person
      first name: Spiridon
      last name: Kamtsios
      member of: Department of Psychology, University of Ioannina, Ioannina, Greece.
  slot:
    index: 2
    item: Kakouris V
      type: Person
      first name: Vasilis
      last name: Kakouris
      member of: Department of Psychology, University of Athens, Athens, Greece.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:24
e ISSN: 1558-691X
has issn l: 0033-2941
has NLM journal title abbreviation: Psychol Rep
publication name: Psychological reports
language: eng
has national library of medicine journal id: 0376475
derived from: NLM
pg: 332941251320026
has place of publication: United States
source: Psychol Rep. 2025-02-14;():332941251320026.

Synergistic Warriors: Design and Synthesis of Dual-Acting Schiff-Based Threaded 1,2,3-Triazole Hybrids for Potent Antineoplastic and Anti-Mycobacterial Activities.
pmid: 39950454
abstract: In the pursuit of identifying divergent scaffolds for potential anticancer and anti-mycobacterial agents, a novel series of Schiff-based threaded 1,2,3-triazoles was designed and synthesized.In this study, novel Schiff-based threaded 1,2,3-triazoles have been meticulously crafted and synthesized. Chemical structures of the synthesized molecules were confirmed by 1H NMR, 13C NMR and Mass spectra. Synthetic analogs were further evaluated for their antiproliferative, antitubercular and antimicrobial potentials by in vitro assays.The in vitro anti-tumor (anti-proliferative) evaluation on HT29 cancer cells revealed that compounds 8b and 8h exhibited remarkable inhibitory activity with IC50 values of 25±0.8 and 24±0.9 μM. In the context of anti-mycobacterial analysis, compound 8c demonstrated promising activity (6.25 μM) against Mycobacterium tuberculosis H37Rv. Moreover, compounds 8d and 8e displayed equipotent antimicrobial potential (3.12 μM) comparable to Ciprofloxacin against both Staphylococcus aureus and Escherichia coli. Molecular docking studies unveiled that 8c exhibited robust binding within the active pocket of carbonic anhydrase XII (docking energy -8.4 kcal/mol) and demonstrated a promising docking profile with β-ketoacyl ACP synthase I (docking energy - 9.5 kcal/mol) in the enzyme's binding pocket.Structure-activity relationship (SAR) analysis identified three pivotal pharmacophores; 1,2,3-triazole, aromatic ring system (substituted with halogens and -NO2), and imine functionalities as crucial for the development of dual inhibitors targeting cancer and tuberculosis, showcasing an outstanding in silico ADMET profile. Therefore, these compounds merit consideration as noteworthy pharmacological lead molecules in the realm of cancer and tuberculosis drug discovery and development.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: MC-EPUB-146607
doi: 10.2174/0115734064318062250206104355
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Walhekar V
      type: Person
      first name: Vinayak
      last name: Walhekar
      member of: Dept. Pharmaceutical Chemistry, BVDUs Poona College of Pharmacy, Erandawane Pune.
  slot:
    index: 2
    item: Kulkarni R
      type: Person
      first name: Raghavendra
      last name: Kulkarni
      member of: Dept. Pharmaceutics, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, India.
  slot:
    index: 3
    item: Nuli MV
      type: Person
      first name: Mohana Vamsi
      last name: Nuli
      member of: Raghavendra Institute of Pharmaceutical Education and Research, Chiyyedu, Ananthapuramu, Andhra Pradesh.
  slot:
    index: 4
    item: Garige AK
      type: Person
      first name: Anil Kumar
      last name: Garige
      member of: Department of Medicinal Chemistry, Jayamukhi Institute of Pharmaceutical Sciences, Narsampet, Warangal, Telangana, India-506332.
  slot:
    index: 5
    item: Deore D
      type: Person
      first name: Dharmesh
      last name: Deore
      member of: Dept. Pharmaceutical Chemistry, BVDUs Poona College of Pharmacy, Erandawane Pune.
  slot:
    index: 6
    item: Pawar R
      type: Person
      first name: Ritesh
      last name: Pawar
      member of: Dept. Pharmaceutical Chemistry, BVDUs Poona College of Pharmacy, Erandawane Pune.
  slot:
    index: 7
    item: Patil A
      type: Person
      first name: Ashwini
      last name: Patil
      member of: Dept. Pharmaceutical Chemistry, BVDUs Poona College of Pharmacy, Erandawane Pune.
  slot:
    index: 8
    item: Dvrn B
      type: Person
      first name: Bhikshapathi
      last name: Dvrn
      member of: Teegala Ram Reddy College of Pharmacy, Meerpet, Balapur, Hyderabad, 500 097.
  slot:
    index: 9
    item: Santosh K
      type: Person
      first name: Karajagi
      last name: Santosh
      member of: Dept. Pharmaceutical Chemistry, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, India.
  slot:
    index: 10
    item: Kulkarni R
      type: Person
      first name: Ravindra
      last name: Kulkarni
      member of: Dept. Pharmaceutical Chemistry, BVDUs Poona College of Pharmacy, Erandawane Pune.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1875-6638
has issn l: 1573-4064
has NLM journal title abbreviation: Med Chem
publication name: Medicinal chemistry (Shariqah (United Arab Emirates))
language: eng
has national library of medicine journal id: 101240303
derived from: NLM
has place of publication: Netherlands
source: Med Chem. 2025-02-11;():.

Design, Synthesis, Characterization, and Antitumor Activities of Benzimidazole-functionalized Organoruthenium Complexes Bearing Fluorine Group.
pmid: 39950455
abstract: This work presents the synthesis of Ru(II)NHC complexes bearing a series of 4-fluorobenzyl group. These complexes have been characterized by a variety of spectroscopic methods (1H NMR, 13C NMR, and FTIR) and by elemental analysis techniques.These complexes' antitumor activities against SH-SY5Y (human neuroblastoma) and HCT116 (human colon cancer) were investigated by 3-(4,5-dimethylthiazole-2-yl)-2,5-biphenyl tetrazolium bromide (MTT) assay.The results showed that all the synthesized complexes exhibited significant cytotoxic effect with low IC50 values 15 ± 0.57, 15.26 ± 0.71, 7.64 ± 0.30, 27.66 ± 0.36 and 14.45 ± 0.84 (μg/mL) respectively.Furthermore, apoptosis assessed by double labeling with Annexin V-FITC/PI indicated that complexes 1b and 1d can effectively induce apoptosis and inhibit cell proliferation at the S phase in SH-SY5Y cells. Taken together, Ru(II)NHC complexes containing the 4- fluorobenzyl group have significant potential for the development of novel, highly effective anticancer agents.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: MC-EPUB-146555
doi: 10.2174/0115734064331622241113032042
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Paşahan R
      type: Person
      first name: Ramazan
      last name: Paşahan
      member of: Department of Neurosurgery, Faculty of Medicine, Inonu University, 44280, Malatya, Türkiye.
  slot:
    index: 2
    item: Demirci Ö
      type: Person
      first name: Özlem
      last name: Demirci
      member of: Department of Chemistry, Faculty of Science, İnönü University, 44280, Malatya, Türkiye.
  slot:
    index: 3
    item: Taşkın Iİ
      type: Person
      first name: Irmak İçen
      last name: Taşkın
      member of: Department of Molecular Biology and Genetics, Faculty of Science and Art, Inonu University, Malatya, Türkiye.
  slot:
    index: 4
    item: Paşahan A
      type: Person
      first name: Aziz
      last name: Paşahan
      member of: Health Services Vocational School, İnönü University, 44280, Malatya, Türkiye.
  slot:
    index: 5
    item: Sever MR
      type: Person
      first name: Meryem Rüveyda
      last name: Sever
      member of: Department of Molecular Biology and Genetics, Faculty of Science and Art, Inonu University, Malatya, Türkiye.
  slot:
    index: 6
    item: Gök Y
      type: Person
      first name: Yetkin
      last name: Gök
      member of: Department of Chemistry, Faculty of Science, İnönü University, 44280, Malatya, Türkiye.
  slot:
    index: 7
    item: Aktaş A
      type: Person
      first name: Aydın
      last name: Aktaş
      member of: Health Services Vocational School, İnönü University, 44280, Malatya, Türkiye.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1875-6638
has issn l: 1573-4064
has NLM journal title abbreviation: Med Chem
publication name: Medicinal chemistry (Shariqah (United Arab Emirates))
language: eng
has national library of medicine journal id: 101240303
derived from: NLM
has place of publication: Netherlands
source: Med Chem. 2025-02-11;():.

Difficulties in Using Natural Herbal Substances and their Current use in Some Pharmaceutical Dosage Forms.
pmid: 39950459
abstract: Random use of natural herbal products affects the treatment of diseases. In this review, the limitations that may be encountered in using natural substances of plant origin and the studies on using these substances in treating cancer, cognitive disorders, heart diseases, diabetes, and microbial diseases are examined and summarized.People worldwide use herbal products derived from natural plants to solve health problems. It is known that random use of herbal products can negatively affect the treatment. However, people need help with the formulation or use of natural substances. There is no new disease-modifying herbal therapy available to treat diseases such as cancer, microbial disorders, diabetes, cognitive disorders, and cardiac disorders.This review aims to report the difficulties encountered in formulating and using natural herbal substances and highlight their possible use in some diseases.Available information about the study was collected through many search engines such as Science Direct, PubMed, and Google Scholar.Working with natural herbal substances worldwide presents many difficulties, especially a lack of knowledge, modern technological devices, or clinical studies. According to currently available studies, some natural herbal substances are effective against cancer, microbial disorders, diabetes, cognitive disorders, and heart disorders.Deepening the studies would be beneficial to eliminate the difficulties related to natural herbal medicines and making them more reliable. More research is needed to include these substances in the protocol and use them in treating diseases.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146587
doi: 10.2174/0113816128346715250120074519
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Özcan Bülbül E
      type: Person
      first name: Ece
      last name: Özcan Bülbül
      member of: Department of Pharmaceutical Technology, Faculty of Pharmacy, Istinye University, Istanbul, Turkey.
  slot:
    index: 2
    item: Üstündağ Okur N
      type: Person
      first name: Neslihan
      last name: Üstündağ Okur
      member of: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-11;():.

The Efficacy and Safety of Direct Oral Anticoagulants Compared to Warfarin in Morbidly Obese Patients on Anticoagulation: A Systematic Review and Meta-Analysis.
pmid: 39950453
abstract: Current guidelines and consensus statements advise caution in using direct oral anticoagulants (DOACs) for morbidly obese patients with body mass index (BMI) >40 kg/m2, indicating warfarin as the most studied treatment.We systematically searched databases from their inception to January 4, 2024, to identify studies that evaluated the effectiveness and safety of DOACs compared to warfarin in patients with BMI >40 kg/m2 and atrial fibrillation (AF) or venous thromboembolism (VTE). The outcomes of allcause mortality, major and minor bleeding, stroke/systematic embolism (SE), VTE, and their composite endpoint were analyzed using a random-effects model.This meta-analysis included 24 studies and 119,960 morbidly obese patients with AF or VTE on oral anticoagulation therapy: 51,363 on DOACs (43%) vs. (57%) 68,597 on warfarin. DOAC use was significantly associated with lower all-cause mortality and major bleeding risk compared to warfarin. Although the risk of composite endpoint, stroke/SE, and VTE was lower in the DOAC group, no statistically significant difference was observed, indicating no superiority of warfarin compared to DOAC use. The risk of minor bleeding events, hemorrhagic stroke, and ischemic stroke was lower in the DOAC compared to the warfarin group. The same trend favoring DOACs over warfarin in all assessed endpoints was observed in the subgroup analysis based on anticoagulation indication (AF or VTE).Our findings have documented a potentially more effective and safer profile of DOACs compared to warfarin in morbidly obese patients regardless of the indication for anticoagulation.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CVP-EPUB-146605
doi: 10.2174/0115701611330090250130075810
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Sagris M
      type: Person
      first name: Marios
      last name: Sagris
      member of: 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
  slot:
    index: 2
    item: Ktenopoulos N
      type: Person
      first name: Nikolaos
      last name: Ktenopoulos
      member of: 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
  slot:
    index: 3
    item: Pamporis K
      type: Person
      first name: Konstantinos
      last name: Pamporis
      member of: Department of Hygiene, Social-Preventive Medicine & Medical Statistics, Medical School, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
  slot:
    index: 4
    item: Gerogianni M
      type: Person
      first name: Maria
      last name: Gerogianni
      member of: Endocrine Unit, 2nd Propaedeutic Department of Internal Medicine, School of Medicine, Research Institute and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, 12641 Athens, Greece.
  slot:
    index: 5
    item: Karakasis P
      type: Person
      first name: Paschalis
      last name: Karakasis
      member of: Second Department of Cardiology, Aristotle University of Thessaloniki, General Hospital 'Hippokration', Thessaloniki, Greece.
  slot:
    index: 6
    item: Theofilis P
      type: Person
      first name: Panagiotis
      last name: Theofilis
      member of: 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
  slot:
    index: 7
    item: Patsourakos N
      type: Person
      first name: Nikolaos
      last name: Patsourakos
      member of: Department of Cardiology, 'Tzaneio' General Hospital of Piraeus, Piraeus, Greece.
  slot:
    index: 8
    item: Toutouzas K
      type: Person
      first name: Konstantinos
      last name: Toutouzas
      member of: 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
  slot:
    index: 9
    item: Tsioufis K
      type: Person
      first name: Konstantinos
      last name: Tsioufis
      member of: 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
  slot:
    index: 10
    item: Tousoulis D
      type: Person
      first name: Dimitris
      last name: Tousoulis
      member of: 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1875-6212
has issn l: 1570-1611
has NLM journal title abbreviation: Curr Vasc Pharmacol
publication name: Current vascular pharmacology
language: eng
has national library of medicine journal id: 101157208
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Vasc Pharmacol. 2025-02-11;():.

Prevalence of Metabolic Syndrome in Iranian Adults Receiving Antiretroviral Treatment for HIV.
pmid: 39950464
abstract: The increased risk of metabolic syndrome (MetS) and its subcomponents among people living with HIV/AIDS, especially in developing countries, is well documented with the global pooled prevalence of the related risk factors in this population.This study aimed to explore the prevalence of MetS among Iranian People living with HIV according to the ATP III and Iranian criteria.The cross-sectional study was conducted on consecutive patients who visited THE re-ferral centre for AIDS/HIV between May to December 2023. A total of 130 participants (n=83; 63.8% male) were investigated based on the inclusion criteria, which included having a minimum age of 25 and a maximum of 65 years and following a stable ART treatment regimen for at least six months. A Chi-square test was used to determine the relationship between the categorical variables. Uni/Multi-variable linear regression analysis was used to quantify the associations be-tween MetS and HIV by the independent variables.The incidence of MetS according to ATP III and Iranian criteria were 42 (32.3%) and 45 (34.6%), which was higher in older patients (p=0.001) and those with more duration since HIV diagnosis (p=0.02). Around 33.1% and 16.1% were overweight and obese, respectively. Among the components of MetS, the highest prevalence (50.8%) was related to low HDL, and the lowest was related to fasting blood sugar (21.5%). The average body fat mass, protein mass, Soft lean mass, and percentage body fat were 18.54±9.46 kg, 10.91±2.17 kg, 51.31±9.61 kg, and 24.86±10.25% that were higher in MetS group (p<0.05).Our study points out the high prevalence of MetS in an Iranian population living with HIV, especially those suffering from the underlying disease for a longer time. Conducting multi-centric studies with larger sample sizes is needed to confirm our results and determine the most effective measures.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CHR-EPUB-146597
doi: 10.2174/011570162X340090250204072449
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Khazdooz H
      type: Person
      first name: Hamid
      last name: Khazdooz
      member of: Department of Endocrinology, Vali-Asr Hospital, Endocrinology, and Metabolism Research Centre, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Abbasian L
      type: Person
      first name: Ladan
      last name: Abbasian
      member of: Iranian Research Center for HIV/AIDS (IRCH), Iranian Institute for Reduction of High Risk Behaviors, Department of Infectious Diseases, Imam Khomeini Complex Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Shirzad N
      type: Person
      first name: Nooshin
      last name: Shirzad
      member of: Department of Endocrinology, Vali-Asr Hospital, Endocrinology, and Metabolism Research Centre, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 4
    item: Khashayar P
      type: Person
      first name: Pouria
      last name: Khashayar
      member of: School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
  slot:
    index: 5
    item: SeyedAlinaghi S
      type: Person
      first name: SeyedAhmad
      last name: SeyedAlinaghi
      member of: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 6
    item: Malekahmadi M
      type: Person
      first name: Mahsa
      last name: Malekahmadi
      member of: Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 7
    item: Hemmatabadi M
      type: Person
      first name: Mahboobeh
      last name: Hemmatabadi
      member of: Department of Endocrinology, Vali-Asr Hospital, Endocrinology, and Metabolism Research Centre, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1873-4251
has issn l: 1570-162X
has NLM journal title abbreviation: Curr HIV Res
publication name: Current HIV research
language: eng
has national library of medicine journal id: 101156990
derived from: NLM
has place of publication: Netherlands
source: Curr HIV Res. 2025-02-11;():.

Pelvic Hematoma Revealing Chronic Myeloid Leukemia: Case Report of Two Patients.
pmid: 39950460
abstract: Chronic myeloid leukemia [CML] is a common hematological malignancy where patients present with varied clinical symptoms and are usually diagnosed with incidentally detected elevated total leucocyte counts in hemogram. The presence of pelvic hematoma at the presentation of CML is an uncommon finding.Two male young adults presented with massive splenomegaly and pelvic hematoma. On evaluation for anemia and leukocytosis with massive splenomegaly, diagnosis of CML chronic phase [CML-CP] was made on peripheral smear, bone marrow examination including cytogenetic study and molecular methods [peripheral blood quantitative BCR: ABL1 by real-- time PCR]. The first patient underwent aspiration of hematoma, and the second patient presented late where the hematoma organized into a solid mass and no intervention could be possible. A basic available coagulation study revealed no abnormalities and was managed with tyrosine kinase inhibitors.Initial manifestation of CML with pelvic hematoma is uncommon and should undergo aspiration or drainage to avoid organization of hematoma and compressive symptoms locally.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CHDDT-EPUB-146557
doi: 10.2174/011871529X365410250131120926
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kachhwaha A
      type: Person
      first name: Arjun
      last name: Kachhwaha
      member of: Department of Medical Oncology Hematology, All India Institute of Medical Sciences, Rishikesh, India.
  slot:
    index: 2
    item: Baveja A
      type: Person
      first name: Avriti
      last name: Baveja
      member of: Department of Hematology, Himalayan Institute of Medical Sciences, SRHU, Dehradun, India.
  slot:
    index: 3
    item: Dev R
      type: Person
      first name: Rahul
      last name: Dev
      member of: Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, India.
  slot:
    index: 4
    item: Huda F
      type: Person
      first name: Farhanul
      last name: Huda
      member of: Department of General Surgery, All India Institute of Medical Sciences, Rishikesh, India.
  slot:
    index: 5
    item: Nath UK
      type: Person
      first name: Uttam Kumar
      last name: Nath
      member of: Department of Medical Oncology Hematology, All India Institute of Medical Sciences, Rishikesh, India.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 2212-4063
has issn l: 1871-529X
has NLM journal title abbreviation: Cardiovasc Hematol Disord Drug Targets
publication name: Cardiovascular & hematological disorders drug targets
language: eng
has national library of medicine journal id: 101269160
derived from: NLM
has place of publication: United Arab Emirates
source: Cardiovasc Hematol Disord Drug Targets. 2025-02-11;():.

Recent Advances in Cationic Nanoemulsions for Drug Delivery: Preparation, Properties, and Applications.
pmid: 39950457
abstract: Nanoemulsions have gained popularity as drug delivery vehicles owing to the enhanced solubility of insoluble drugs, the augmented stability of photo- and thermosensitive substances, and the facilitation of transdermal permeation of efficacy substances. As the cell surfaces of the skin, cornea, gastrointestinal mucosa, and other cells in living organisms carry negative charges, cationic nanoemulsions (CNE) mainly promote drug absorption through electrostatic effects. In this review, a brief characterization of CNEs is provided, and the types of cationic agents and their roles in nanoemulsions, including cationic surfactants, cationic lipids, cationic polymers, cationized polysaccharides, and phytosphingosine (PS), are discussed. In addition, the current application circumstances of CNEs in ocular drug delivery, mucosal drug delivery, and transdermal drug delivery systems are elaborated on, and the crucial matters that require attention during the research process are briefly discussed. Eventually, the extensive application prospects of CNEs are envisioned.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPD-EPUB-146603
doi: 10.2174/0113816128357859250121120216
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: He H
      type: Person
      first name: Huanfan
      last name: He
      member of: Institute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
  slot:
    index: 2
    item: Li J
      type: Person
      first name: Jiayu
      last name: Li
      member of: Institute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
  slot:
    index: 3
    item: Meng H
      type: Person
      first name: Hong
      last name: Meng
      member of: Institute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
  slot:
    index: 4
    item: He Y
      type: Person
      first name: Yifan
      last name: He
      member of: Institute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
  slot:
    index: 5
    item: Pei X
      type: Person
      first name: Xiaojing
      last name: Pei
      member of: Institute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
  slot:
    index: 6
    item: Zhang Z
      type: Person
      first name: Ze
      last name: Zhang
      member of: Light Industry and Food Experimental Teaching Center, Beijing Technology and Business University, Beijing, China.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:33
e ISSN: 1873-4286
has issn l: 1381-6128
has NLM journal title abbreviation: Curr Pharm Des
publication name: Current pharmaceutical design
language: eng
has national library of medicine journal id: 9602487
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Pharm Des. 2025-02-11;():.

Base Mediated 7-exo-dig Intramolecular Cyclization of Betti-propargyl Precursors: An Efficient Approach to 1,4-oxazepine Derivatives.
pmid: 39950461
abstract: 1,4-oxazepine is a significant structural motif found in several bio-active molecules used in the treatment of diseases such as psychotic disorders.Therefore, developing novel methodologies for its preparation is of great interest to medicinal chemists.These seven-membered heterocycles are generated through the intramolecular cy-clization of Betti bases, which are propargylated using propargyl bromide as the source of the triple bond in the presence of a base.This efficient and straightforward protocol proceeds under mild, metal-free conditions and has been shown to be applicable to a broad range of aldehydes and 2-aminopyridines.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: COS-EPUB-146553
doi: 10.2174/0115701794353226241209175136
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Yazzaf R
      type: Person
      first name: Rozita
      last name: Yazzaf
      member of: School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran.
  slot:
    index: 2
    item: Asadi M
      type: Person
      first name: Mina
      last name: Asadi
      member of: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Mahdavi M
      type: Person
      first name: Mohammad
      last name: Mahdavi
      member of: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
ISSN: 1570-1794
has issn l: 1570-1794
has NLM journal title abbreviation: Curr Org Synth
publication name: Current organic synthesis
language: eng
has national library of medicine journal id: 101208457
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Org Synth. 2025-02-11;():.

Long-term Sustained Response to Lenalidomide after Clearance of Bone Marrow Blasts by Azacytidine in High-risk Myelodysplastic Syndromes with Del5q: A Case Report.
pmid: 39950462
abstract: This report discusses a rare case involving a patient with high-risk (HR) Del(5q) myelodysplastic syndrome (MDS) who achieved a long-term response to lenalidomide after having received six cycles of azacytidine. The latter treatment led to the clearance of blast cells from the bone marrow (BM).As per current clinical practice, patients with HR MDS receive azacytidine continuously until the disease progresses or the occurrence of unmanageable side effects. However, in this case, the patient decided to interrupt hypomethylation therapy. Due to the patient's preference for oral therapy at home, the absence of blast cells, the ongoing need for transfusions, and a cytogenetic abnormality-predictive response to lenalidomide, the choice of the latter agent allowed for a sustained response lasting up to 68 months.Our observations suggest that further studies could explore the sequential use of azacytidine followed by lenalidomide after achieving BM blast clearance in patients with HR MDS with del(5q).
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CHAMC-EPUB-146558
doi: 10.2174/0118715257341062250130103015
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Niscola P
      type: Person
      first name: Pasquale
      last name: Niscola
      member of: Hematology Unit, Sant'Eugenio Hospital (ASL Roma 2), Rome, Italy.
  slot:
    index: 2
    item: Giovannini M
      type: Person
      first name: Marco
      last name: Giovannini
      member of: Hematology Unit, Sant'Eugenio Hospital (ASL Roma 2), Rome, Italy.
  slot:
    index: 3
    item: Gianfelici V
      type: Person
      first name: Valentina
      last name: Gianfelici
      member of: Hematology Unit, Sant'Eugenio Hospital (ASL Roma 2), Rome, Italy.
  slot:
    index: 4
    item: Mazzone C
      type: Person
      first name: Carla
      last name: Mazzone
      member of: Hematology Unit, Sant'Eugenio Hospital (ASL Roma 2), Rome, Italy.
  slot:
    index: 5
    item: de Fabritiis P
      type: Person
      first name: Paolo
      last name: de Fabritiis
      member of: Hematology Unit, Sant'Eugenio Hospital (ASL Roma 2), Rome, Italy.
  slot:
    index: 6
    item: Oliva EN
      type: Person
      first name: Esther Natalie
      last name: Oliva
      member of: Hematology Division, Great Metropolitan Hospital Bianchi Melacrino Morelli, Reggio, Calabria, Italy.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-6182
has issn l: 1871-5257
has NLM journal title abbreviation: Cardiovasc Hematol Agents Med Chem
publication name: Cardiovascular & hematological agents in medicinal chemistry
language: eng
has national library of medicine journal id: 101266881
derived from: NLM
has place of publication: Netherlands
source: Cardiovasc Hematol Agents Med Chem. 2025-02-11;():.

Inconsistent Protein Stability Despite Pre-HECT Domain Helix: Unveiling Variability in HECT Ligases.
pmid: 39950466
abstract: Ubiquitin and ubiquitin-like systems play crucial roles across a wide range of organisms, from simple to complex. Among the three enzyme-mediated post-translational modification (PTM) steps, the ligation step is the most critical. HERC5, a member of the HECT ligase family, is one of the three enzymes involved in the ISGylation system. However, the precise start points and lengths of the HECT domains in HECT ligases are still under debate.Some studies suggest the inclusion of an additional N-terminal alpha helix region within the HECT domain. To investigate the structural biology of the HECT domain of HERC5, we produced and purified various lengths of the HERC5 HECT domain using different fusion proteins. This approach allowed us to explore the role of the N-terminal alpha helix in the stability of the HECT domain. Our experiments successfully produced and purified HERC5 HECT domains of different lengths with various fusion proteins.The findings demonstrated that the N-terminal alpha-helix does not enhance the stability of the HECT domain. These results challenge the notion that the N-terminal alpha-helix should be generally included in the HECT domain across all HECT ligases.The inclusion of this region within the HECT domain may not be appropriate for generalization, as it does not contribute to stability, contrary to some previous suggestions.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: PPL-EPUB-146610
doi: 10.2174/0109298665362863250114075840
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Dağ Ç
      type: Person
      first name: Çağdaş
      last name: Dağ
      member of: Nanofabrication and Nanocharacterization Center for Scientific and Technological Advanced Research (n2STAR), Koc University, İstanbul, Turkey.Koc University Isbank Center for Infectious Diseases (KUISCID), Koc University, Istanbul, Turkey.
  slot:
    index: 2
    item: Tozkoparan Ceylan CD
      type: Person
      first name: Cansu Deniz
      last name: Tozkoparan Ceylan
      member of: Nanofabrication and Nanocharacterization Center for Scientific and Technological Advanced Research (n2STAR), Koc University, İstanbul, Turkey.
  slot:
    index: 3
    item: Cansız CS
      type: Person
      first name: Cemre Sare
      last name: Cansız
      member of: Nanofabrication and Nanocharacterization Center for Scientific and Technological Advanced Research (n2STAR), Koc University, İstanbul, Turkey.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-5305
has issn l: 0929-8665
has NLM journal title abbreviation: Protein Pept Lett
publication name: Protein and peptide letters
language: eng
has national library of medicine journal id: 9441434
derived from: NLM
has place of publication: Netherlands
source: Protein Pept Lett. 2025-02-11;():.

Combating Drug Resistance in Lung Cancer: Exploring the Synergistic Potential of Metformin and Cisplatin in a Novel Combination Therapy; A Systematic Review.
pmid: 39950484
abstract: The persistent drug resistance observed in lung cancer necessitates innovative strategies to improve therapeutic outcomes. This review investigates the potential of combining metformin (Met) and cisplatin (Cis) to overcome drug resistance and enhance treatment efficacy. Cis's limitations, including drug resistance and adverse effects, coupled with Met's established safety profile, form the backdrop for this exploration.Systematic literature searches across major databases identified relevant studies exploring the synergistic effects of Met and Cis in the context of drug-resistant lung cancer. Data extraction encompassed diverse facets, including treatment protocols, cellular responses, and mechanistic insights. The synthesis of these findings sheds light on the potential of this combination therapy to combat drug resistance.Numerous in vitro and in vivo studies have demonstrated the ability of the Met + Cis combination to sensitize drug-resistant lung cancer cells. The co-treatment consistently showed enhanced inhibition of cell proliferation, elevated apoptosis rates, and attenuated migration and invasion capabilities compared to monotherapies. Mechanistically, Met's modulatory effect on key pathways, such as AMPK-mTOR and ROS-mediated signaling, appears to underlie its ability to counter drug resistance.The Met + Cis combination holds promise as an innovative strategy to counter drug resistance in lung cancer. By harnessing the synergistic effects of these agents, combination therapy offers a novel approach to enhance treatment efficacy and mitigate the challenges posed by drug-resistant lung cancer. Although further clinical validation is required, the Met + Cis synergy represents a promising avenue in the pursuit of improved lung cancer therapy outcomes.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-145486
doi: 10.2174/0115680266317788241121100259
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Jafarzadeh E
      type: Person
      first name: Emad
      last name: Jafarzadeh
      member of: Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Sarajar BO
      type: Person
      first name: Behnam Omidi
      last name: Sarajar
      member of: Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Lalani AR
      type: Person
      first name: Armineh Rezaghol
      last name: Lalani
      member of: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 4
    item: Rastegar-Pouyani N
      type: Person
      first name: Nima
      last name: Rastegar-Pouyani
      member of: Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 5
    item: Aliebrahimi S
      type: Person
      first name: Shima
      last name: Aliebrahimi
      member of: Artificial Intelligence in Medical Sciences Research Center, Smart University of Medical Sciences, Tehran, Iran.
  slot:
    index: 6
    item: Montazeri V
      type: Person
      first name: Vahideh
      last name: Montazeri
      member of: Artificial Intelligence in Medical Sciences Research Center, Smart University of Medical Sciences, Tehran, Iran.
  slot:
    index: 7
    item: Ghahremani MH
      type: Person
      first name: Mohammad H
      last name: Ghahremani
      member of: Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 8
    item: Ostad SN
      type: Person
      first name: Seyed Nasser
      last name: Ostad
      member of: Toxicology and Poisoning Research Centre, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-11;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39950483
pmid: 39950483
abstract: Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are severe disorders characterized by progressive neuron degeneration, leading to cognitive decline, motor dysfunction, and other neurological issues, significantly impairing daily life and the quality of life. Despite advancements in understanding these mechanisms, many aspects remain unclear, and current treatments primarily manage symptoms without halting disease progression. Multiple biological pathways are implicated in neurodegeneration, including oxidative stress, neuroinflammation, mitochondrial dysfunction, and aberrant protein folding. Given the multifactorial nature of neurodegenerative diseases, a neuroprotective approach targeting various mechanisms holds significant promise for prevention. Natural products derived from plants, animals, and fungi, known for their antioxidant and anti-inflammatory properties, show substantial potential in the prevention of neurodegeneration. Unlike synthetic compounds, bioactive compounds from these natural sources offer diverse targets due to their varied structures and biological activities. This review focuses on the potential of bioactive compounds from plants with sedative and mood-modulating effects in preventing and/or slowing down neurodegeneration.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CN-EPUB-146575
doi: 10.2174/011570159X345397241210103538
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Silvia P
      type: Person
      first name: Piccirillo
      last name: Silvia
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
  slot:
    index: 2
    item: Preziuso A
      type: Person
      first name: Alessandra
      last name: Preziuso
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
  slot:
    index: 3
    item: Tiziano S
      type: Person
      first name: Serfilippi
      last name: Tiziano
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
  slot:
    index: 4
    item: Cerqueni G
      type: Person
      first name: Giorgia
      last name: Cerqueni
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
  slot:
    index: 5
    item: Terenzi V
      type: Person
      first name: Valentina
      last name: Terenzi
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
  slot:
    index: 6
    item: Lariccia V
      type: Person
      first name: Vincenzo
      last name: Lariccia
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
  slot:
    index: 7
    item: Magi S
      type: Person
      first name: Simona
      last name: Magi
      member of: Department of Biomedical Sciences and Public Health, School of Medicine, University 'Politecnica delle Marche', Via Tronto 10/A, 60126 Ancona, Italy.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-6190
has issn l: 1570-159X
has NLM journal title abbreviation: Curr Neuropharmacol
publication name: Current neuropharmacology
language: eng
has national library of medicine journal id: 101157239
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Neuropharmacol. 2025-02-11;():.
title: Unveiling the Potential Neuroprotective Effect of Bioactive Compounds from Plants with Sedative and Mood-Modulating Properties: Innovative Approaches for the Prevention of Alzheimer's and Parkinson's Diseases.

In silico based Diabetic Wound Healer from Nature: An Update.
pmid: 39950482
abstract: Diabetes is a chronic metabolic disease of high levels of glucose in the blood and affecting 536.6 million people in the world between the age group of 20-79 with management spent of 11% of the total worldwide. Wound healing in diabetics is impaired due to many factors like high blood sugar, poor blood circulation, damaged blood vessels, diabetic neuropathy, decreased immune responses etc. The presently used synthetic drugs have high costs, a toxic nature, and are full of adverse effects drawing attention to the need to identify new and successful treatment approaches for diabetic wounds. In silico drug screening methods of drug development made it easy to screen thousands of active constituents against a target specifically responsible for diabetes and wound healing. Thus the current review compiled the naturally available active compounds screened by in silico docking from natural resources and has the potential to treat diabetic wound healing with their specificity and target-based mechanism. This information will be helpful for further screening of non-reported natural compounds having antidiabetic as well as wound healing potential.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CDDT-EPUB-146594
doi: 10.2174/0115701638336128250122223221
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lather A
      type: Person
      first name: Amit
      last name: Lather
      member of: Geeta Institute of Pharmacy, Geeta University, Panipat, Haryana, India.
  slot:
    index: 2
    item: Rathee P
      type: Person
      first name: Pratibha
      last name: Rathee
      member of: MM College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala, Haryana, India.
  slot:
    index: 3
    item: Gautam MK
      type: Person
      first name: Manish Kumar
      last name: Gautam
      member of: Faculty of Pharmaceutical Science, Assam downtown University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati- 781026, Assam, India.
  slot:
    index: 4
    item: Sharma K
      type: Person
      first name: Kalicharan
      last name: Sharma
      member of: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga Punjab, India.
  slot:
    index: 5
    item: Hooda T
      type: Person
      first name: Tanuj
      last name: Hooda
      member of: MM College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala, Haryana, India.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-6220
has issn l: 1570-1638
has NLM journal title abbreviation: Curr Drug Discov Technol
publication name: Current drug discovery technologies
language: eng
has national library of medicine journal id: 101157212
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Drug Discov Technol. 2025-02-11;():.

Integrative Analysis of Metabolomic and Transcriptomic Data Reveals Metabolic Signatures and Major Metabolic Pathways in Primary Aldosteronism.
pmid: 39950479
abstract: Primary aldosteronism (PA) is the most common secondary hypertension. In this study, we performed the pathway enrichment analysis based on metabolomics and transcriptomic data to find the metabolic perturbations in PA, which could provide new targets for PA and further understand the biology of PA.24 PA patients and 24 healthy adults served as the control group in this study. Six participants were chosen from each group to have their peripheral blood and serum samples analyzed for omics investigations. Another eighteen participants' peripheral blood samples were selected for further validation of the RNA-sequencing results.Transcriptomic analyses found 518 differentially expressed genes (DEGs), and 339 remarkably differential metabolites (DMs) were identified by untargeted metabolomics. The pathway enrichment analysis was performed by combining with the omics analysis data. We also focused on analyzing metabolic pathways that repeatedly occur and constructed possible genemetabolic networks. A total of 5 genes and 11 metabolites showed significant changes in altered 3 lipid metabolic pathways. Furthermore, the expressions of these genes were verified by qRT-PCR.The combination of metabolomic and transcriptomic data can give a comprehensive picture of unique illness markers and preliminary knowledge of the molecular abnormalities underpinning PA. These findings may point to viable targets for creating treatments.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: EMIDDT-EPUB-146570
doi: 10.2174/0118715303361250250119035029
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lai X
      type: Person
      first name: Xiaomei
      last name: Lai
      member of: Department of Rehabilitation Medicine, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, China.
  slot:
    index: 2
    item: Yang T
      type: Person
      first name: Tingting
      last name: Yang
      member of: Department of Cardiology, Liuzhou People's Hospital, Liuzhou, Guangxi 545026, China.
  slot:
    index: 3
    item: Wei C
      type: Person
      first name: Chaoping
      last name: Wei
      member of: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
  slot:
    index: 4
    item: Zhu S
      type: Person
      first name: Shuangbei
      last name: Zhu
      member of: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
  slot:
    index: 5
    item: Li J
      type: Person
      first name: Jianling
      last name: Li
      member of: Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.Postdoctoral Mobile Station of Guangxi Medical University, Nanning, Guangxi 530021, China.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 2212-3873
has issn l: 1871-5303
has NLM journal title abbreviation: Endocr Metab Immune Disord Drug Targets
publication name: Endocrine, metabolic & immune disorders drug targets
language: eng
has national library of medicine journal id: 101269157
derived from: NLM
has place of publication: United Arab Emirates
source: Endocr Metab Immune Disord Drug Targets. 2025-02-11;():.

Screening Co-Diagnostic Genes for Lung Adenocarcinoma and Myocardial Infarction and Analysis of the Molecular Functions and Drug Value of the Genes.
pmid: 39950480
abstract: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer, and myocardial infarction (MI) is an acute cardiovascular disease resulting from the disruption of coronary blood supply. Recent studies have suggested that these two diseases may share common molecular mechanisms.The aim of this study was to discover common diagnostic genes for LUAD and MI and analyze their molecular functions and potential drug values by applying bioinformatics analysis.The objective was to provide a theoretical basis for further research on the pathological mechanisms of LUAD and MI, contributing to the development of novel diagnostic and therapeutic strategies for the two diseases.In this study, the datasets of LUAD and MI were obtained from TCGA and GEO databases, and differential expression analysis was performed to screen significantly differentially expressed genes (DEGs). Subsequently, disease-related genes were identified using WGCNA analysis, and the biological functions of these genes were explored by functional enrichment analysis. After screening key genes using the protein-protein interaction (PPI) network and the cytoHubba algorithm, biomarkers were determined by LASSO and SVM-RFE machine-learning methods. Finally, immune infiltration analysis and drug prediction were performed, and biomarker expression was verified by single-cell sequencing analysis.A total of 158 differentially upregulated genes were identified between LUAD and MI. WGCNA analysis screened 86 genes that were significantly associated with both diseases and were enriched in an inflammatory response and immune regulation-related pathways, such as the IL-17 signaling pathway. Ten significant genes were identified by the PPI network and cytoHubba and then reduced to 4 using LASSO and SVM-RFE. Noticeably, MMP9 was significantly overexpressed in both diseases. Immune infiltration analysis showed that MMP9 was significantly related to multiple immune cell infiltration. Drug prediction and m[cell cut: 2601 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: EMIDDT-EPUB-146572
doi: 10.2174/0118715303374928250130113050
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Du N
      type: Person
      first name: Nannan
      last name: Du
      member of: Department of Traditional Chinese Medicine, The Fourth People's Hospital of Bengbu, Bengbu, 233010, China.
  slot:
    index: 2
    item: Liang M
      type: Person
      first name: Mengting
      last name: Liang
      member of: Department of Infection, Shanghai Longhua Hospital, Shanghai, 200032, China.
  slot:
    index: 3
    item: Liu Z
      type: Person
      first name: Zongjun
      last name: Liu
      member of: Cardiology Department, Shanghai Putuo District Central Hospital, Shanghai, 200062, China.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 2212-3873
has issn l: 1871-5303
has NLM journal title abbreviation: Endocr Metab Immune Disord Drug Targets
publication name: Endocrine, metabolic & immune disorders drug targets
language: eng
has national library of medicine journal id: 101269157
derived from: NLM
has place of publication: United Arab Emirates
source: Endocr Metab Immune Disord Drug Targets. 2025-02-11;():.

Association between Insulin-Like Growth Factor Binding Protein-7 and Heart Failure.
pmid: 39950473
abstract: Heart failure (HF), a widespread public health issue, affects about 26 million people all around the world, and its incidence and prevalence are still growing. Measuring serum biomarkers is beneficial in diagnosing HF and evaluating its prognosis. During the previous decade, various investigations have focused on identifying new HF biological markers that would have additional and/or superior prognostic, diagnostic, or classification value. While heart-specific biological markers, such as atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), are commonly applied in clinical practice, there is still an unmet need for new markers in HF management. Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, has been considered as a candidate biomarker in HF. This study aims to comprehensively reveal the underlying mechanism connecting IGFBP-7 to HF and review studies evaluating the prognostic or diagnostic performance of IGFBP-7 in combination with or in contrast with other potential HF biological markers. Increased IGFBP7 levels are associated with a set of functional and structural heart abnormalities such as diastolic dysfunction. Increased IGFBP7 concentrations seem to be an indicator of cardiac overload or injury and are related to HF major risk factors, including atherosclerosis, diabetes, and renal function. IGFBP7 is predictive of short and long-term outcomes in the HF population and can independently predict the rate of hospitalization and HF-related mortality.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CMC-EPUB-146599
doi: 10.2174/0109298673346933241223063559
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ghasempour P
      type: Person
      first name: Parisa
      last name: Ghasempour
      member of: Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
  slot:
    index: 2
    item: Khanmohammadi S
      type: Person
      first name: Shaghayegh
      last name: Khanmohammadi
      member of: Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Rezaei N
      type: Person
      first name: Nima
      last name: Rezaei
      member of: Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-533X
has issn l: 0929-8673
has NLM journal title abbreviation: Curr Med Chem
publication name: Current medicinal chemistry
language: eng
has national library of medicine journal id: 9440157
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Med Chem. 2025-02-11;():.

Transporter Associated with Antigen Processing Proteins (TAP-1 and TAP-2) Gene Expression of MHC-I Downregulated in Oral Squamous Carcinoma.
pmid: 39950478
abstract: TAP-1 and TAP-2 are crucial proteins for loading antigenic peptides after proteasome-mediated endogenous processing of the MHC-I (Major Histocompatibility Complex- I) pathway. Our study aimed to explore the Transporter Associated with Antigen Processing proteins (TAP-1 and TAP-2) in oral squamous cell carcinoma and premalignant oral lesions.We recruited a total of 135 subjects from the outpatient department of the ENT unit of our institute. Real-time Polymerase Chain Reaction (PCR) was used to evaluate the levels of TAP-1 and TAP-2 gene expression in pre-cancerous and oral squamous carcinoma samples. Additionally, we measured the circulating levels of inflammatory markers using an automated biochemistry analyzer.In the current study, we found that the subjects with oral squamous cell carcinoma had lower expressions of the TAP 1 and TAP 2 genes than precancerous oral subjects of OSMF, leukoplakia, and OLP. In oral squamous carcinoma subjects, we found a 1.7- and 2.1-fold change in gene expression of TAP-1 and TAP-2, respectively, compared to control subjects. Furthermore, we observed an increase in levels of metabolic inflammatory biomarkers of CRP, ESR, and ferritin in oral squamous carcinoma subjects compared to premalignant cases and controls, indicating the presence and aggravation of systemic inflammation.The study revealed that subjects with oral squamous cell carcinoma have lower TAP 1 and TAP 2 gene expression than premalignant control subjects, thus affecting MHC-I processing, which ultimately affects the functioning of the immune system. These results have the potential to improve our understanding of disease pathophysiology and provide more targeted treatment options.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: EMIDDT-EPUB-145840
doi: 10.2174/0118715303344715241225184322
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Singh V
      type: Person
      first name: Vijay
      last name: Singh
      member of: Department of Biochemistry, All India Institute of Medical Sciences Gorakhpur, 273008, India.
  slot:
    index: 2
    item: Dwivedi S
      type: Person
      first name: Shailendra
      last name: Dwivedi
      member of: Department of Biochemistry, All India Institute of Medical Sciences Gorakhpur, 273008, India.
  slot:
    index: 3
    item: Agrawal R
      type: Person
      first name: Ruchika
      last name: Agrawal
      member of: Department of ENT, All India Institute of Medical Sciences Gorakhpur, 273008, India.
  slot:
    index: 4
    item: Ps MR
      type: Person
      first name: Mohan Raj
      last name: Ps
      member of: Department of Biochemistry, All India Institute of Medical Sciences Gorakhpur, 273008, India.
  slot:
    index: 5
    item: Bansal A
      type: Person
      first name: Akash
      last name: Bansal
      member of: Department of Biochemistry, All India Institute of Medical Sciences Gorakhpur, 273008, India.
  slot:
    index: 6
    item: Agarwal A
      type: Person
      first name: Akash
      last name: Agarwal
      member of: Department of Surgical Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences Lucknow, 226010 India.
  slot:
    index: 7
    item: Misra S
      type: Person
      first name: Sanjeev
      last name: Misra
      member of: Atal Bihari Bajpayee Medical University, Lucknow, 225001, India; and All India Institute of Medical Sciences Jodhpur, 243005, India.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 2212-3873
has issn l: 1871-5303
has NLM journal title abbreviation: Endocr Metab Immune Disord Drug Targets
publication name: Endocrine, metabolic & immune disorders drug targets
language: eng
has national library of medicine journal id: 101269157
derived from: NLM
has place of publication: United Arab Emirates
source: Endocr Metab Immune Disord Drug Targets. 2025-02-11;():.

WISP3/CCN6 Adipocytokine Marker in Patients with Non-alcoholic Fatty Liver Disease (NAFLD) and its Association with Some Risk Factors.
pmid: 39950485
abstract: CCN6/WISP3 is a member of the CCN adipokines family that can exert multiple effects on metabolic pathways. So far, the function of CCN6 in the pathogenesis of NAFLD has not been known well. Hence, we aimed to examine CCN6 serum levels in patients with NAFLD compared to healthy individuals and its association with some risk factors for the first time.This case-control study measured serum levels of CCN6, TNF-α, IL-6, adiponectin, and fasting insulin using ELISA kits in 88 NAFLD patients and 88 controls. In addition, other biochemical variables, including AST, ALT, lipid profiles, and FBG, were determined using an Auto analyzer instrument.A remarkable decrease in CCN6 levels was found in the NAFLD patients (1501.9543 ± 483.414 pg/ml) compared to the healthy group (1899.4856 ± 559.704 pg/ml, P < 0.001). In NAFLD patients, a negatively notable correlation was observed between CCN6 and the levels of insulin (r = -0.278, P = 0.011), HOMA-IR (r = -0.268, P = 0.014), as well as TNF-α (r = -0.343, P = 0.001). A remarkable association was found between CCN6 and the risk factor of NAFLD in the adjusted model for gender, age, and BMI with OR = 0.867 (95% CI, [0.806-0.931], P < 0.001).Our findings showed a significant reduction in CCN6 levels in the NAFLD patients compared to the healthy group, as well as the developing risk of NAFLD enhanced with the decrease of CCN6 levels.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CTMC-EPUB-146576
doi: 10.2174/0115680266334590241217065614
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Alsaedi HZR
      type: Person
      first name: Hayder Zeyad Raheemah
      last name: Alsaedi
      member of: Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Dashti N
      type: Person
      first name: Nasrin
      last name: Dashti
      member of: Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Fadaei R
      type: Person
      first name: Reza
      last name: Fadaei
      member of: Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.
  slot:
    index: 4
    item: Moradi N
      type: Person
      first name: Nariman
      last name: Moradi
      member of: Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  slot:
    index: 5
    item: Naeini FB
      type: Person
      first name: Farinaz Baghaei
      last name: Naeini
      member of: Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  slot:
    index: 6
    item: Afrisham R
      type: Person
      first name: Reza
      last name: Afrisham
      member of: Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1873-4294
has issn l: 1568-0266
has NLM journal title abbreviation: Curr Top Med Chem
publication name: Current topics in medicinal chemistry
language: eng
has national library of medicine journal id: 101119673
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Top Med Chem. 2025-02-11;():.

A Potential Regulatory Network of Selected Human Erythrocytic miRNAs with Plasmodium falciparum 3D7 mRNAs: A Computational Analysis.
pmid: 39950472
abstract: miRNAs are small non-coding conserved RNA molecules (18-24 nts) that act as crucial gene regulators via post-transcriptional/translational modifications through in-teracting with the respective mRNAs during various pathophysiological conditions. Recent re-search has suggested that non-coding RNAs, particularly miRNAs, can be passed from one spe-cies to another to regulate gene expression. Since miRNA-mediated gene regulation has not yet been found in Plasmodia, it is hypothesized that erythrocytic miRNAs from Plasmodium falcipa-rum (P. falciparum) could potentially migrate from the cytoplasm to the parasitophorous vacuole developed intracellularly by the parasite to regulate its transcriptome.The objective of this study is to investigate the role of trans-kingdom interactions in host-parasite dynamics and their implications for malaria infection.Using the trans-kingdom target gene prediction tool, psRNA target server, a total of 15 human erythrocytic miRNAs from 12 distinct families were selected and obtained from miRBase to find potential P. falciparum candidate genes. This study utilized ShinyGO (version 0.80) for gene enrichment analysis with statistical analysis of the selected features. The PPI-network analysis was performed using the Maximal Clique Centrality (MCC) approach, along with the CytoHubba plugin for identifying hub nodes. The PPI network was visualized using Cytoscape version 3.7.A total of 145 target genes of Pf3D7 were predicted, with the following genes repeatedly targeted: conserved Plasmodium proteins, conserved Plasmodium membrane proteins, PfEMP1, rifin, RAD54, E3 ubiquitin-protein ligase, and transcription factors related genes. Outputs of ShinyGO included enriched GO pathways of 62 uniquely identified Pf3D7 genes with detailed descriptions and visualized networks. For overlapping relationships, a hierarchical clustering tree of enriched gene sets was carried out, along with a genome plot for representing the chromosomal locations of these g[cell cut: 2743 characters, first 2000 kept]
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: MIRNA-EPUB-146608
doi: 10.2174/0122115366321119250123113447
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Joshi U
      type: Person
      first name: Urja
      last name: Joshi
      member of: Department of Biochemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
  slot:
    index: 2
    item: Motwani H
      type: Person
      first name: Harsha
      last name: Motwani
      member of: Department of Botany, Bioinformatics and CCIM, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
  slot:
    index: 3
    item: Jani D
      type: Person
      first name: Dhara
      last name: Jani
      member of: Department of Zoology, Biomedical Technology and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
  slot:
    index: 4
    item: George LB
      type: Person
      first name: Linz-Buoy
      last name: George
      member of: Department of Zoology, Biomedical Technology and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
  slot:
    index: 5
    item: Highland H
      type: Person
      first name: Hyacinth
      last name: Highland
      member of: Department of Zoology, Biomedical Technology and Human Genetics, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 2211-5374
has NLM journal title abbreviation: Microrna
publication name: MicroRNA (Shariqah, United Arab Emirates)
language: eng
has national library of medicine journal id: 101631045
derived from: NLM
has place of publication: United Arab Emirates
source: Microrna. 2025-02-11;():.

The Impact of Novel Lipid-Lowering Agents on Cardiovascular Risk Reduction: A Systematic Review and Meta-Analysis.
pmid: 39950470
abstract: Reducing the risk of atherosclerotic cardiovascular disease is the aim of lipid-lowering therapy (ASCVD). It is commonly acknowledged that low-density lipoprotein (LDL) is a major cause of ASCVD. Several online databases and search engines, such as Pub- Med and the Cochrane Library, were used to conduct a thorough search.This study included RCTs assessing the effect of PCSK9 inhibitors on cardiovascular events. The RevMan 5.4 software was used to conduct the meta-analysis. This analysis included nine RCTs in total.Meta-analysis of the included studies showed that the levels of total cholesterol, LDL, and triglycerides were reduced after the use of PCSK9 inhibitors, and HDL levels were increased, which is good cholesterol. Most adverse cardiac events (MACE) were reduced after the use of PCSK9 inhibitors.In conclusion, ezetimibe, a PCSK9 inhibitor added to statin therapy, further reduces MACE risk without affecting all-cause mortality, even though statins already significantly reduce major adverse cardiovascular events (MACE) and mortality.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CCR-EPUB-146647
doi: 10.2174/011573403X345749250122092324
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ray R
      type: Person
      first name: Rubela
      last name: Ray
      member of: Bankura Sammilani Medical College, Bankura, India.
  slot:
    index: 2
    item: Mahmood A
      type: Person
      first name: Arhum
      last name: Mahmood
      member of: Henry Ford Health System, Detroit, USA.
  slot:
    index: 3
    item: Chaudhry R
      type: Person
      first name: Raheel
      last name: Chaudhry
      member of: Baylor College of Medicine, Houston, USA.
  slot:
    index: 4
    item: Masmoum MD
      type: Person
      first name: Mohd Diya
      last name: Masmoum
      member of: Alfaisal University, Riyadh, Saudi Arabia.
  slot:
    index: 5
    item: Talha M
      type: Person
      first name: Muhammad
      last name: Talha
      member of: Nishtar Medical University, Multan, Pakistan.
  slot:
    index: 6
    item: Siddiqui FI
      type: Person
      first name: Fahad I
      last name: Siddiqui
      member of: Multan Medical and Dental College, Multan, Pakistan.
  slot:
    index: 7
    item: Ullah I
      type: Person
      first name: Imdad
      last name: Ullah
      member of: Khyber Medical College, Peshawar, Pakistan.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T06:34
e ISSN: 1875-6557
has issn l: 1573-403X
has NLM journal title abbreviation: Curr Cardiol Rev
publication name: Current cardiology reviews
language: eng
has national library of medicine journal id: 101261935
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Cardiol Rev. 2025-02-13;():.

Predictive Accuracy of 24-Hour Ambulatory Blood Pressure Monitoring Versus Clinic Blood Pressure for Cardiovascular and All-Cause Mortality: A Systematic Review and Meta-Analysis.
pmid: 39950476
abstract: According to current clinical practice guidelines, ambulatory blood pressure measurement (ABPM) is recommended to confirm diagnoses of hypertension. It remains unclear as to which method is superior in predicting mortality outcomes.Prospective observational studies, comparing ABPM with clinical blood pressure measurements (CBPM), were included with outcomes of the study being all-cause and cardiovascular mortality.Nine studies with a total of 23,140 participants were included. Each 10-mmHg increase in 24-hour mean systolic blood pressure (SBP) was linked to a higher risk of all-cause mortality (HR: 1.13, 95% CI: 1.09-1.18), while clinic blood pressure measurement (CBPM) was not a significant predictor (HR: 1.02, 95% CI: 0.90-1.13). Nighttime SBP increases of 10 mmHg were associated with a higher all-cause mortality risk than daytime SBP (HR: 1.16, 95% CI: 1.11-1.21 versus HR: 1.08, 95% CI: 1.05-1.12). For cardiovascular mortality, a 10 mmHg increase in SBP yielded an HR of 1.21 (95% CI: 1.16-1.27) for 24-hour ABPM compared to 1.08 (95% CI: 1.04-1.11) for CBPM. Similarly, for a 5 mmHg increase in diastolic blood pressure (DBP), the HR was 1.14 (95% CI: 1.07-1.20) for 24-hour ABPM versus 1.04 (95% CI: 1.01-1.07) for clinical DBP, highlighting 24-hour monitoring as a stronger predictor for cardiovascular mortality.The findings of this study support the superiority of ABPM measurements in predicting both all-cause and cardiovascular mortality.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CHYR-EPUB-146598
doi: 10.2174/0115734021337639250203175636
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Soleimani H
      type: Person
      first name: Hamidreza
      last name: Soleimani
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Mohammadi NSH
      type: Person
      first name: Negin Sadat Hosseini
      last name: Mohammadi
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 3
    item: Montazeri Namin S
      type: Person
      first name: Sara
      last name: Montazeri Namin
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 4
    item: Nasrollahizadeh A
      type: Person
      first name: Amir
      last name: Nasrollahizadeh
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Cardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 5
    item: Azardar T
      type: Person
      first name: Tara
      last name: Azardar
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 6
    item: Najafi K
      type: Person
      first name: Kimia
      last name: Najafi
      member of: Hakim Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 7
    item: Cilingiroglu M
      type: Person
      first name: Mehmet
      last name: Cilingiroglu
      member of: University of Texas in Houston, MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 8
    item: Syed M
      type: Person
      first name: Mushabbar
      last name: Syed
      member of: Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.
  slot:
    index: 9
    item: Askari MK
      type: Person
      first name: Mani K
      last name: Askari
      member of: Department of Medicine, University of Toledo, Ohio, USA.
  slot:
    index: 10
    item: Gupta R
      type: Person
      first name: Rahul
      last name: Gupta
      member of: Department of Cardiology, Lehigh Valley Health Network, Allentown, PA, USA.
  slot:
    index: 11
    item: Aronow WS
      type: Person
      first name: Wilbert S
      last name: Aronow
      member of: Department of Cardiology, New York Medical College and Westchester Medical Center, Valhalla, NY, USA.
  slot:
    index: 12
    item: Hosseini K
      type: Person
      first name: Kaveh
      last name: Hosseini
      member of: Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-6506
has issn l: 1573-4021
has NLM journal title abbreviation: Curr Hypertens Rev
publication name: Current hypertension reviews
language: eng
has national library of medicine journal id: 101239891
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Hypertens Rev. 2025-02-11;():.

Engineered Anti-Microbial Peptides Inhibit Cell Viability, Promote Apoptosis, and Induce Cell Cycle Arrest in SW620 Human Colon Adenocarcinoma Cells.
pmid: 39950468
abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and despite advances in treatment, there remains a critical need for novel therapeutic approaches. Recently, anti-microbial peptides (AMPs) have gained attention for their potential use in cancer therapy due to their selective cytotoxicity towards cancer cells.This study aims to evaluate the anti-cancer potential of two computationally engineered anti-microbial peptides (EAMPs) in SW620, SW480, and HCT116 colon cancer cells and the normal colon epithelial cell line CCD 841, focusing on their effects on cell proliferation, apoptosis, and DNA damage.Cell proliferation and survival were measured using the CellTiter-Glo Luminescence and clonogenic assays. DNA damage was assessed through the Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Flow cytometry was used to examine cell apoptosis, cell cycle distribution, and mitochondrial membrane potential in SW620 cells.EAMPs inhibited CRC cell proliferation in a dose-dependent manner, with minimal toxicity observed in normal colon epithelial cells. In SW620 cells, EAMPs induced DNA damage, resulting in cell cycle arrest at the S/G2 phase, apoptosis, and a reduction in mitochondrial membrane potential. The proliferation results were confirmed in SW480 and HCT116 CRC cell lines.Our findings revealed that EAMPs exhibited significant anti-cancer activity against CRC cells in vitro while sparing normal epithelial cells. These results suggest that EAMPs may offer a potential therapeutic approach for colorectal cancer and warrant further investigation.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CPPS-EPUB-146604
doi: 10.2174/0113892037363898250110053529
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Hashem S
      type: Person
      first name: Sheema
      last name: Hashem
      member of: Environmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, Qatar.Department of Human Genetics, Sidra Medicine, Doha, Qatar.
  slot:
    index: 2
    item: Bhat AA
      type: Person
      first name: Ajaz A
      last name: Bhat
      member of: Department of Human Genetics-Precision Medicine in Diabetes, Obesity and Cancer Program, Sidra Medicine, Doha, Qatar.
  slot:
    index: 3
    item: Nisar S
      type: Person
      first name: Sabah
      last name: Nisar
      member of: Environmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, Qatar.Department of Human Genetics, Sidra Medicine, Doha, Qatar.
  slot:
    index: 4
    item: Uddin S
      type: Person
      first name: Shahab
      last name: Uddin
      member of: Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar.
  slot:
    index: 5
    item: Merhi M
      type: Person
      first name: Maysaloun
      last name: Merhi
      member of: Translational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
  slot:
    index: 6
    item: Mateo JM
      type: Person
      first name: Jericha M
      last name: Mateo
      member of: Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
  slot:
    index: 7
    item: Prabhu KS
      type: Person
      first name: Kirti S
      last name: Prabhu
      member of: Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
  slot:
    index: 8
    item: Soubra L
      type: Person
      first name: Lama
      last name: Soubra
      member of: Environmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, Qatar.
  slot:
    index: 9
    item: Dos Santos Silva CA
      type: Person
      first name: Carlos André
      last name: Dos Santos Silva
      member of: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  slot:
    index: 10
    item: Benko-Iseppon AM
      type: Person
      first name: Ana Maria
      last name: Benko-Iseppon
      member of: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  slot:
    index: 11
    item: Vilela LMB
      type: Person
      first name: Lívia Maria Batista
      last name: Vilela
      member of: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  slot:
    index: 12
    item: de Lima MO
      type: Person
      first name: Marx Oliveira
      last name: de Lima
      member of: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  slot:
    index: 13
    item: da Silva JG
      type: Person
      first name: Juliana Georgia
      last name: da Silva
      member of: Department of Genetics, Federal University of Pernambuco, Recife, Brazil.
  slot:
    index: 14
    item: Haris M
      type: Person
      first name: Mohammad
      last name: Haris
      member of: Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar.Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
  slot:
    index: 15
    item: Suleman M
      type: Person
      first name: Muhammad
      last name: Suleman
      member of: Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar.
  slot:
    index: 16
    item: Crovella S
      type: Person
      first name: Sergio
      last name: Crovella
      member of: Laboratory of Animal Research Center (LARC), Qatar University, Doha, Qatar.
  slot:
    index: 17
    item: Abou Saleh H
      type: Person
      first name: Haissam
      last name: Abou Saleh
      member of: Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-5550
has issn l: 1389-2037
has NLM journal title abbreviation: Curr Protein Pept Sci
publication name: Current protein & peptide science
language: eng
has national library of medicine journal id: 100960529
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Protein Pept Sci. 2025-02-11;():.

Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation.
pmid: 39950474
abstract: Promoting neuroplasticity for better recovery and function restoration has lately become the focus of rehabilitation techniques for individuals with neurologic disorders. A rapidly expanding medical specialty, neuromodulation includes a broad variety of methods for activating particular neurological pathways, such as Transcranial magnetic stimulation (TMS), Transcranial direct current stimulation (tDCS), peripheral nerve stimulation, and SCS, among many others. Research on the use of neuromodulation in the context of spinal cord injury (SCI) is limited, in contrast to the abundance of literature on its potential benefits in chronic pain treatment. Combining exercise with non-invasive neuromodulation improves recovery outcomes for some patient groups, according to our research. While we mostly focus on the motor components of recovery, we do briefly mention the non-motor effects of these disorders. The difficulties of applying ideas in clinical practice and the gaps in the existing research are also brought to light. In order to better customize the individual neuroplastic responses associated with each disease, we identify research gaps and propose routes for future investigations. This review is useful for rehabilitation professionals and researchers since it focuses on neuroplastic exercise treatments for specific illnesses and diagnoses. Few studies have used long-term randomized-controlled trials, even though these approaches have great promise for enhancing overall functionality and impairment levels. If these novel modalities may be therapeutically employed to reduce pain, restore function, and improve the quality of life for individuals impacted, then more study is required to support them.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CNSNDDT-EPUB-146600
doi: 10.2174/0118715273341882250114054733
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Nath P
      type: Person
      first name: Patralika
      last name: Nath
      member of: Department of Physiotherapy, National Institute for Locomotor Disabilities (NILD), Kolkata, West Bengal, India.
  slot:
    index: 2
    item: Roy B
      type: Person
      first name: Barnana
      last name: Roy
      member of: Department of Physiotherapy, School of Health Sciences, Garden City University, Bangaluru, India.
  slot:
    index: 3
    item: Panigrahi SS
      type: Person
      first name: Soumya Saswati
      last name: Panigrahi
      member of: Department of Pediatrics, Burdwan Medical College, West Bengal, India.
  slot:
    index: 4
    item: Islam K
      type: Person
      first name: Kamirul
      last name: Islam
      member of: Department of Physiotherapy, School of Paramedics and Allied Health Sciences, Jatni, Khurda Road, Odisha, India.
  slot:
    index: 5
    item: Basak AK
      type: Person
      first name: Asim Kumar
      last name: Basak
      member of: Department of Allied Health Sciences, Brainware University, Barasat, West Bengal, India.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1996-3181
has issn l: 1871-5273
has NLM journal title abbreviation: CNS Neurol Disord Drug Targets
publication name: CNS & neurological disorders drug targets
language: eng
has national library of medicine journal id: 101269155
derived from: NLM
has place of publication: United Arab Emirates
source: CNS Neurol Disord Drug Targets. 2025-02-11;():.

Epigenetic Mechanisms of Antibiotic Resistance.
pmid: 39950477
abstract: Antibiotic resistance remains a major challenge in the use of antimicrobial agents and poses a threat to public health worldwide. This review discusses the epigenetic mechanisms underlying antibiotic resistance. Significant attention is also given to gene expression patterns that promote microbial adaptability and survival in the context of antibiotic therapy, as well as epigenetic mechanisms that contribute to modifying the activity of resistance genes. The authors argue that epigenetics plays a key role in the development and spread of antibiotic resistance. By offering new perspectives on the complex interaction between genetic and epigenetic regulations in microbial populations using metal nanoparticles, the authors shed light on potential therapeutic targets and strategies to combat antibiotic resistance. Exploring the disclosure of epigenetic mechanisms when interacting with metal nanoparticles on resistant cultures is insufficiently covered in the literature. This review not only presents the latest scientific findings in this field but also opens up avenues for further research that will help address the growing problem of antibiotic resistance.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CMM-EPUB-146569
doi: 10.2174/0115665240366292250210045958
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Novozhilova PO
      type: Person
      first name: Polina O
      last name: Novozhilova
      member of: Siberian State Medical University' of the Ministry of Health of Russia; Russia, 634050, Tomsk, Russia.
  slot:
    index: 2
    item: Bakina OV
      type: Person
      first name: Olga V
      last name: Bakina
      member of: Siberian State Medical University' of the Ministry of Health of Russia; Russia, 634050, Tomsk, Russia.Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences, 2/4, pr. Akademicheskii, Tomsk, 634055, Russia.
  slot:
    index: 3
    item: Spirina LV
      type: Person
      first name: Liudmila V
      last name: Spirina
      member of: Siberian State Medical University' of the Ministry of Health of Russia; Russia, 634050, Tomsk, Russia.
  slot:
    index: 4
    item: Tarasenko NV
      type: Person
      first name: Natalya V
      last name: Tarasenko
      member of: Siberian State Medical University' of the Ministry of Health of Russia; Russia, 634050, Tomsk, Russia.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-5666
has issn l: 1566-5240
has NLM journal title abbreviation: Curr Mol Med
publication name: Current molecular medicine
language: eng
has national library of medicine journal id: 101093076
derived from: NLM
has place of publication: Netherlands
source: Curr Mol Med. 2025-02-11;():.

The Role of Red Blood Cells in Cholesterol Accumulation and Atherosclerotic Plaque Instability: A Perspective on Atherosclerosis.
pmid: 39950471
abstract: Atherosclerosis stands as the primary cause of CVD, characterized by the accumulation of cholesterol deposits within macrophages in medium and large arteries. This deposition promotes the proliferation of specific cell types within the arterial wall, gradually narrowing the vessel lumen and impeding blood flow. Intra-plaque hemorrhages are recognized as critical events in atherosclerotic plaques, leading to the deposition of red blood cells (RBCs) and the release of hemoglobin (Hb). Approximately 40% of high-risk plaques exhibit intra-plaque hemorrhage. Recent studies have demonstrated that intra-plaque hemorrhage is closely linked to plaque progression and increased vulnerability, establishing it as a critical factor in the development of acute clinical symptoms associated with atherosclerosis. The presence of RBC membranes within atherosclerotic plaques contributes significantly to lipid accumulation, indicating a pivotal role in plaque instability. Upon RBC degradation, cholesterol from both the membrane and its interior can profoundly impact atherosclerotic plaque development. Considering that red blood cells (RBCs) can contribute to the excretion of cholesterol through the hepatobiliary system alongside HDL, and given that elevated cholesterol levels are a risk factor for the development and progression of atherosclerotic plaques, RBCs may play a protective role in cardiovascular health. However, when bleeding occurs within a plaque, RBCs that are trapped in the plaque environment, an environment rich in oxidant compounds, can rupture. The cholesterol released from these ruptured RBCs can significantly promote inflammatory reactions. This study aims to explore the inconsistent role of RBCs and their cholesterol content in the progression of atherosclerotic plaques.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CCR-EPUB-146593
doi: 10.2174/011573403X358572250128104335
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Mohebbati R
      type: Person
      first name: Reza
      last name: Mohebbati
      member of: Department of Physiology, Faculty of Medicine, Gonabad University of Medical Science, Gonabad, Iran.
  slot:
    index: 2
    item: Moghaddam MAM
      type: Person
      first name: Mohammad Amin Momeni
      last name: Moghaddam
      member of: Department of Nutrition and Biochemistry, Faculty of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Science, Gonabad, Iran.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-6557
has issn l: 1573-403X
has NLM journal title abbreviation: Curr Cardiol Rev
publication name: Current cardiology reviews
language: eng
has national library of medicine journal id: 101261935
derived from: NLM
has place of publication: United Arab Emirates
source: Curr Cardiol Rev. 2025-02-11;():.

In vitro and In vivo Drug Metabolism Analysis of BPI-460372 - A Covalent TEAD1/3/4 Inhibitor.
pmid: 39950481
abstract: BPI-460372 is an orally available, covalent, irreversible small molecule inhibitor of the transcriptional enhanced associate domain (TEAD) 1/3/4, which is currently in clinical development for the treatment of cancers with Hippo pathway alterations.This study aimed to determine the cytochrome P450 (CYP) phenotyping, metabolic stability, and in vitro and in vivo metabolic profile of BPI-460372.The CYP phenotyping and metabolic stability were assessed by measuring the depletion of substrate. The metabolic profile in hepatocytes and rat and dog plasma was analyzed using ultra-high-performance liquid chromatography combined with Orbitrap tandem mass spectrometry (UHPLC-Orbitrap-HRMS).BPI-460372 was mainly metabolized by CYP2D6, CYP3A4, and CYP1A2. BPI-460372 exhibited low clearance in human, monkey, and rat hepatocytes, while moderate clearance in dog and mouse hepatocytes. A total of 10 metabolites were identified in five species of hepatocytes, and no human-unique metabolite was detected. In rat plasma and dog plasma, the primary metabolites were M407 (BPI-460430) and M423 (BPI-460456), respectively. The two metabolites were quantitatively determined in rat and dog plasma in pharmacokinetic and toxicological studies. The major metabolic site was 2-fluoro-acrylamide, and major metabolic pathways in hepatocytes, and rat and dog plasma involved oxidative defluorination, hydration, glutathione (GSH) conjugation, hydrolysis, cysteine conjugation, and N-acetyl cysteine conjugation. β-lyase pathway contributed to the metabolism of BPI-460372 in rats to a certain degree.This study elucidated the metabolism of BPI-460372 and provided a basis for pharmacokinetic and toxicological species selection, human pharmacokinetics prediction, and assessment of clinical co-administration limitations and possible metabolic pathways in humans.
rights: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
has PII: CDM-EPUB-146595
doi: 10.2174/0113892002351556250123105344
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Liu X
      type: Person
      first name: Xiaoyun
      last name: Liu
      member of: Betta Pharmaceuticals Co., Ltd, Hangzhou, 311100, China.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  slot:
    index: 2
    item: Zhong D
      type: Person
      first name: Dafang
      last name: Zhong
      member of: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  slot:
    index: 3
    item: Tang CZ
      type: Person
      first name: Chong Zhuang
      last name: Tang
      member of: XenoFinder Co., Ltd, Suzhou 215123, China.
  slot:
    index: 4
    item: Xu X
      type: Person
      first name: Xiaofeng
      last name: Xu
      member of: Betta Pharmaceuticals Co., Ltd, Hangzhou, 311100, China.
  slot:
    index: 5
    item: Lan H
      type: Person
      first name: Hong
      last name: Lan
      member of: Betta Pharmaceuticals Co., Ltd, Hangzhou, 311100, China.
  slot:
    index: 6
    item: Diao X
      type: Person
      first name: Xingxing
      last name: Diao
      member of: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.XenoFinder Co., Ltd, Suzhou 215123, China.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-11
dp: 2025 Feb 11
created: 2025-2-14T06:34
e ISSN: 1875-5453
has issn l: 1389-2002
has NLM journal title abbreviation: Curr Drug Metab
publication name: Current drug metabolism
language: eng
has national library of medicine journal id: 100960533
derived from: NLM
has place of publication: Netherlands
source: Curr Drug Metab. 2025-02-11;():.

Accelerating inverse Kohn-Sham calculations using reduced density matrices.
pmid: 39950508
abstract: The Ryabinkin-Kohut-Staroverov (RKS) and Kanungo-Zimmerman-Gavini (KZG) methods offer two approaches to find exchange-correlation (XC) potentials from ground state densities. The RKS method utilizes the one- and two-particle reduced density matrices to alleviate any numerical artifacts stemming from a finite basis (e.g., Gaussian- or Slater-type orbitals). The KZG approach relies solely on the density to find the XC potential by combining a systematically convergent finite-element basis with appropriate asymptotic correction on the target density. The RKS method, being designed for a finite basis, offers computational efficiency. The KZG method, using a complete basis, provides higher accuracy. In this work, we combine both methods to simultaneously afford accuracy and efficiency. In particular, we use the RKS solution as an initial guess for the KZG method to attain a significant 3-11× speedup. This work also presents a direct comparison of the XC potentials from the RKS and the KZG method and their relative accuracy on various weakly and strongly correlated molecules, using their ground state solutions from accurate configuration interaction calculations solved in a Slater orbital basis.
rights: © 2025 Author(s). Published under an exclusive license by AIP Publishing.
has PII: 3335902
doi: 10.1063/5.0241971
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kanungo B
      type: Person
      first name: Bikash
      last name: Kanungo
      member of: Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
  slot:
    index: 2
    item: Tribedi S
      type: Person
      first name: Soumi
      last name: Tribedi
      member of: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
  slot:
    index: 3
    item: Zimmerman PM
      type: Person
      first name: Paul M
      last name: Zimmerman
      member of: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
  slot:
    index: 4
    item: Gavini V
      type: Person
      first name: Vikram
      last name: Gavini
      member of: Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:53
e ISSN: 1089-7690
has issn l: 0021-9606
issue: 6
has NLM journal title abbreviation: J Chem Phys
publication name: The Journal of chemical physics
language: eng
has national library of medicine journal id: 0375360
derived from: NLM
has place of publication: United States
source: J Chem Phys. 2025-02-14;162(6):.
volume: 162

Working memory capacity and self-cues: Consistent benefits in children and adults.
pmid: 39950510
abstract: From attentional prioritization to enhanced memory, self-cues trigger a variety of effects within human cognition. Recent work suggests that self-reference may also enhance working memory, possibly via attentional prioritization. However, there is no direct evidence that self-cues enhance working memory capacity, or that such boosts covary with individuals' attentional function. Here, we provide the first direct evidence of enhanced working memory capacity for self-referential cues, independent of attentional processing. We adapted a verbal working memory complex span to create a 'Self' condition (featuring the participant's own name), 'Other' condition (featuring a non-self-name), and Control condition (with no name), in 7-9-year-old children (Exp.1, N = 71) and adults (Exp.2, N = 52). In both experiments, the Self condition elicited significantly higher spans than the other conditions (Exp 1: p < .001, ηp 2 = .32; Exp 2: p < .001, ηp 2 = .25), but this increase in capacity was unrelated to measures of attentional processing or backward digit span. Moreover, equivalent boosts were observed in children and adults, despite adults' significantly higher underlying capacity. We propose a chunking interpretation based on enhanced binding of self-associated items, directly benefiting individual's working memory capacity regardless of their current attentional competence or 'baseline' capacity.
rights: © 2025 The Author(s). British Journal of Psychology published by John Wiley & Sons Ltd on behalf of The British Psychological Society.
doi: 10.1111/bjop.12778
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ahmed Z
      type: Person
      first name: Zahra
      last name: Ahmed
      member of: Faculty of Social and Applied Sciences, Kydd Building, Abertay University, Dundee, UK.School of Health in Social Science, Old Medical School, University of Edinburgh, Edinburgh, UK.
  slot:
    index: 2
    item: McLean JF
      type: Person
      first name: Janet F
      last name: McLean
      member of: Faculty of Social and Applied Sciences, Kydd Building, Abertay University, Dundee, UK.
  slot:
    index: 3
    item: Allan K
      type: Person
      first name: Kevin
      last name: Allan
      member of: School of Psychology, William Guild Building, University of Aberdeen, Aberdeen, UK.
  slot:
    index: 4
    item: Cunningham SJ
      type: Person
      first name: Sheila J
      last name: Cunningham
      member of: Faculty of Social and Applied Sciences, Kydd Building, Abertay University, Dundee, UK.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:53
e ISSN: 2044-8295
has issn l: 0007-1269
has NLM journal title abbreviation: Br J Psychol
publication name: British journal of psychology (London, England : 1953)
language: eng
has national library of medicine journal id: 0373124
derived from: NLM
has place of publication: England
source: Br J Psychol. 2025-02-14;():.

Importance of muscle health during CAR T therapy: A physiatrist's role during CAR T therapy.
pmid: 39950549
doi: 10.1002/pmrj.13353
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Strader S
      type: Person
      first name: Shannon
      last name: Strader
      member of: Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, and Immune Progenitor and Cell Therapeutics (IMPACT) Lab, Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 2
    item: DiGuardo M
      type: Person
      first name: Margaret
      last name: DiGuardo
      member of: Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, and Immune Progenitor and Cell Therapeutics (IMPACT) Lab, Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 3
    item: Barksdale T
      type: Person
      first name: Toure
      last name: Barksdale
      member of: Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:55
e ISSN: 1934-1563
has issn l: 1934-1482
has NLM journal title abbreviation: PM R
publication name: PM & R : the journal of injury, function, and rehabilitation
language: eng
has national library of medicine journal id: 101491319
derived from: NLM
has place of publication: United States
source: PM R. 2025-02-14;():.

Identifying malaligned knee screw during ultrasound examination.
pmid: 39950536
doi: 10.1002/pmrj.13344
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Türkekul P
      type: Person
      first name: Pelin
      last name: Türkekul
      member of: Department of Rehabilitation and Sports Medicine, Second Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic.
  slot:
    index: 2
    item: Jačisko J
      type: Person
      first name: Jakub
      last name: Jačisko
      member of: Department of Rehabilitation and Sports Medicine, Second Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic.
  slot:
    index: 3
    item: Jevič F
      type: Person
      first name: Filip
      last name: Jevič
      member of: Department of Rehabilitation and Sports Medicine, Second Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic.
  slot:
    index: 4
    item: Kobesova A
      type: Person
      first name: Alena
      last name: Kobesova
      member of: Department of Rehabilitation and Sports Medicine, Second Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic.
  slot:
    index: 5
    item: Özçakar L
      type: Person
      first name: Levent
      last name: Özçakar
      member of: Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:54
e ISSN: 1934-1563
has issn l: 1934-1482
has NLM journal title abbreviation: PM R
publication name: PM & R : the journal of injury, function, and rehabilitation
language: eng
has national library of medicine journal id: 101491319
derived from: NLM
has place of publication: United States
source: PM R. 2025-02-14;():.

Preemptive iodide treatment in the event of a nuclear disaster: The prepper's guide to the galaxy.
pmid: 39950539
doi: 10.1113/EP092154
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Cramon PK
      type: Person
      first name: Per Karkov
      last name: Cramon
      member of: Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.Department of Endocrinology and Metabolism, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  slot:
    index: 2
    item: Holm S
      type: Person
      first name: Søren
      last name: Holm
      member of: Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  slot:
    index: 3
    item: Berg RMG
      type: Person
      first name: Ronan M G
      last name: Berg
      member of: Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T06:54
e ISSN: 1469-445X
has issn l: 0958-0670
has NLM journal title abbreviation: Exp Physiol
publication name: Experimental physiology
language: eng
has national library of medicine journal id: 9002940
derived from: NLM
has place of publication: England
source: Exp Physiol. 2025-02-14;():.

Departments.
pmid: 39950563
doi: 10.1002/pmrj.13362
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T07:03
e ISSN: 1934-1563
has issn l: 1934-1482
issue: 2
has NLM journal title abbreviation: PM R
publication name: PM & R : the journal of injury, function, and rehabilitation
language: eng
has national library of medicine journal id: 101491319
derived from: NLM
starting page: E1
ending page: E9
has place of publication: United States
source: PM R. 2025-02;17(2):E1-E9.
volume: 17

How to manage an implant displaced in the maxillary sinus.
pmid: 39950564
has PII: 5938232
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Chiapasco M
      type: Person
      first name: Matteo
      last name: Chiapasco
  slot:
    index: 2
    item: Tommasato G
      type: Person
      first name: Grazia
      last name: Tommasato
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T07:03
ISSN: 2198-591X
issue: 1
has NLM journal title abbreviation: Int J Esthet Dent
publication name: The international journal of esthetic dentistry
language: eng
has national library of medicine journal id: 101624416
derived from: NLM
pg: 94
has place of publication: Germany
source: Int J Esthet Dent. 2025-02-14;20(1):94.
volume: 20

The prognostic significance and role of adjuvant therapy for low-volume nodal metastasis in apparent early stage endometrial cancer: an updated systematic review and meta-analysis.
pmid: 39950608
abstract: Sentinel lymph node biopsy (SLNB) has improved detection of low-volume node metastasis (LVNM) in endometrial cancer (EC), but its prognostic significance and the need for adjuvant therapy (AT) remain unclear. A comprehensive search was performed until August 31, 2024 in multiple databases and sources. From 21 studies, 65,228 apparent early-stage EC patients were identified: 370 with macrometastases (MAC), 526 with micrometastases (MM), 2,138 with isolated tumor cells (ITCs), and 62,194 with negative nodes. Findings indicated: 1) The MM group had a lower risk of recurrence or progression (R/P) than the MAC group (risk ratio [RR]=0.49; 95% confidence interval [CI]=0.31-0.78; p=0.002), higher risk than the negative nodes group (RR=2.07; 95% CI=1.59-2.68; p<0.001), and similar risk to the ITC group (RR=0.67; 95% CI=0.44-1.02; p=0.060). 2) The MM group had higher 3-year progression-free survival (PFS) (RR=1.36; 95% CI=1.21-1.52; p<0.001) and overall survival (OS) (RR=1.22; 95% CI=1.09-1.37; p<0.001) than the MAC group, similar to the ITC and negative nodes groups. 3) The ITC group had a lower R/P risk and higher 3-year PFS/OS than the MAC group, similar to the negative nodes group. 4) AT reduced the R/P risk in the MM group (RR=0.41; 95% CI=0.22-0.76; p=0.005) and increased 3-year OS in the ITC group (RR=1.06; 95% CI=1.04-1.08; p<0.001). Early-stage EC with LVNM had better prognostic outcomes than MAC, and AT may improve outcomes of LVNM patients. More evidence from prospective randomized controlled trials is needed to confirm these findings due to the inherent biases of retrospective studies. Trial Registration PROSPERO Identifier: CRD42022364536.
rights: © 2025. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.
has PII: 36.e67
doi: 10.3802/jgo.2025.36.e67
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zhuang Y
      type: Person
      first name: Yuan
      last name: Zhuang
      member of: Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  slot:
    index: 2
    item: Xu Y
      type: Person
      first name: Yue
      last name: Xu
      member of: Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  slot:
    index: 3
    item: Deng P
      type: Person
      first name: Panxia
      last name: Deng
      member of: Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
  slot:
    index: 4
    item: Wang S
      type: Person
      first name: Shengnan
      last name: Wang
      member of: Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 5
    item: Nie H
      type: Person
      first name: Huilong
      last name: Nie
      member of: Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. niehlong@mail.sysu.edu.cn.
  slot:
    index: 6
    item: Yang H
      type: Person
      first name: Hua
      last name: Yang
      member of: Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. yangh353@mail.sysu.edu.cn.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-10
dp: 2025 Feb 10
created: 2025-2-14T07:33
e ISSN: 2005-0399
has issn l: 2005-0380
has NLM journal title abbreviation: J Gynecol Oncol
publication name: Journal of gynecologic oncology
language: eng
has national library of medicine journal id: 101483150
derived from: NLM
has place of publication: Korea (South)
source: J Gynecol Oncol. 2025-02-10;():.

Lipedema awareness in fibromyalgia.
pmid: 39950611
abstract: To evaluate the presence of lipedema and lipedema-related factors in fibromyalgia patients.The study included 100 female patients over the age of 18 who met the fibromyalgia diagnostic criteria. The patients were evaluated for the presence/stages of lipedema. The body mass index (BMI), waist-hip ratio, waist-height ratio, and presence of hematoma tendency/telangiectasias were recorded. Patients were asked to mark the severity of their pain (widespread/on lipedema) on a 10 cm visual analog scale (VAS). The ACR 2016 Fibromyalgia Diagnostic Criteria, The Beck Depression Inventory (BDI), and The Revised Fibromyalgia Impact Questionnaire were applied.Lipedema was observed in 50% of the patients (58% Stage 1 lipedema). In the lipedema group, age, duration of fibromyalgia diagnosis, hematoma tendency/presence of telangiectasias (for all; p < .001), menopausal status (p = .004), BDI score (p = .04), BMI (p = .02), history of medication for fibromyalgia (p = .01) were higher, and age at menarche (p = .01) was lower. Lipedema stage was moderately positively correlated with BMI, number of pregnancies (for both; r:0.53 p < .001) and waist-height ratio (r:0.43 p:0.002), while VAS-lipedema pain intensity was strongly positively correlated with VAS-widespread pain intensity (r:0.62 p < .001), and moderately positively correlated with symptom severity score (r:0.55 p < .001), BMI (r:0.54 p < .001), and fibromyalgia severity score (r:0.51 p < .001). Long fibromyalgia diagnosis time (p: 0.005), and low age at menarche (p: 0.05) were significant risk factors for the presence of lipedema.Lipedema is common in fibromyalgia patients. Long fibromyalgia diagnosis time and low age at menarche are significant risk factors for the presence of lipedema.
doi: 10.1177/02683555251321042
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Bolkan Günaydın E
      type: Person
      first name: Elzem
      last name: Bolkan Günaydın
      member of: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ufuk University, Ankara, Turkey.
  slot:
    index: 2
    item: Ünlü Z
      type: Person
      first name: Zeliha
      last name: Ünlü
      member of: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
  slot:
    index: 3
    item: Ay S
      type: Person
      first name: Saime
      last name: Ay
      member of: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey.
  slot:
    index: 4
    item: Karapınar TO
      type: Person
      first name: Tolga Oğuz
      last name: Karapınar
      member of: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
created: 2025-2-14T12:30
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T07:42
e ISSN: 1758-1125
has issn l: 0268-3555
has NLM journal title abbreviation: Phlebology
publication name: Phlebology
language: eng
has national library of medicine journal id: 9012921
derived from: NLM
pg: 2683555251321042
has place of publication: England
source: Phlebology. 2025-02-14;():2683555251321042.

46,XX testicular disorder of sexual differentiation (DSD) presenting as gynaecomastia in an adolescent.
pmid: 39950623
has PII: 17/12/e263118
doi: 10.1136/bcr-2024-263118
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Alam A
      type: Person
      first name: Ahmad
      last name: Alam
      member of: Endocrinology, Jawaharlal Nehru Medical College and Hospital, Aligarh, India.India.
  slot:
    index: 2
    item: Karthik V
      type: Person
      first name: Vijayakumar
      last name: Karthik
      member of: Endocrinology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India kannanhbk91@gmail.com.NIMS Medicity, Thiruvananthapuram, Kerala, India.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2024-12-20
dp: 2024 Dec 20
created: 2025-2-14T07:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-20;17(12):.
volume: 17

Extramedullary haematopoietic pseudotumour presenting as chest masses and respiratory failure in a patient with thalassemia major.
pmid: 39950619
has PII: 17/12/e261055
doi: 10.1136/bcr-2024-261055
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Singh P
      type: Person
      first name: Priyanka
      last name: Singh
      member of: Pulmonary Medicine, Army Hospital Research and Referral, New Delhi, New Delhi, India.
  slot:
    index: 2
    item: Ahuja NB
      type: Person
      first name: Nitin Balram
      last name: Ahuja
      member of: Military Hospital Namkum, Ranchi, Jharkhand, India.
  slot:
    index: 3
    item: Tiwari S
      type: Person
      first name: Saurabh
      last name: Tiwari
      member of: Pulmonary Medicine, Army Hospital Research and Referral, New Delhi, New Delhi, India.
  slot:
    index: 4
    item: Yanamandra U
      type: Person
      first name: Uday
      last name: Yanamandra
      member of: Internal Medicine & Hematology, Armed Forces Medical College, Pune, Maharashtra, India udayj2@gmail.com.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2024-12-20
dp: 2024 Dec 20
created: 2025-2-14T07:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-20;17(12):.
volume: 17

Congenital alopecia with multiple nodules over face in an infant.
pmid: 39950638
has PII: 17/12/e263595
doi: 10.1136/bcr-2024-263595
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Madhudiya R
      type: Person
      first name: Rinkal
      last name: Madhudiya
      member of: Dermatology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  slot:
    index: 2
    item: Parmar V
      type: Person
      first name: Vimesh
      last name: Parmar
      member of: Neonatology, All India Institute of Medical Science - Bhopal, Bhopal, Madhya Pradesh, India vimeshparmar03@gmail.com.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2024-12-22
dp: 2024 Dec 22
created: 2025-2-14T07:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-22;17(12):.
volume: 17

Cortical functional connectivity following mild traumatic brain injury: A narrative review of applications.
pmid: 39950636
abstract: In this narrative review, we explore the insights from current research in functional neuroimaging following mild traumatic brain injury (mTBI), with a specific focus on alterations in functional connectivity and its relationship to deficits in executive functioning. Secondly, we identify implications that changes in functional connectivity have for language processing and management of cognitive-communication disorders. The search included CINAHL, PubMed, and APA Psychinfo databases, including terms mTBI, functional connectivity, cognitive deficits, and associated functional imaging tools. After all exclusionary criteria were applied, 19 studies were included. This review shows that alterations in functional connectivity networks following mTBI are sensitive for presence of injury. However, the presentation appears widely heterogeneous as of this time, highlighting the need for further research, especially investigating differences of within-subject methods and between-subject/group comparisons. While functional magnetic resonance imaging is the most commonly applied resource, functional near-infrared spectroscopy has become an easily accessible alternative, which may prove more useful for future studies. The roles for neuroimaging technology and measurements of functional connectivity are continuing to take shape, and they will likely represent a significant step forward for more personalized and effective strategies in assessment and treatment of mTBI.
doi: 10.1080/23279095.2025.2464066
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: White RK
      type: Person
      first name: Ryan K
      last name: White
      member of: Communication Sciences and Disorders, Baylor University, Waco, TX, USA.
  slot:
    index: 2
    item: Park J
      type: Person
      first name: Jungjun
      last name: Park
      member of: Communication Sciences and Disorders, Baylor University, Waco, TX, USA.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T07:53
e ISSN: 2327-9109
has issn l: 2327-9095
has NLM journal title abbreviation: Appl Neuropsychol Adult
publication name: Applied neuropsychology. Adult
language: eng
has national library of medicine journal id: 101584082
derived from: NLM
starting page: 1
ending page: 14
has place of publication: United States
source: Appl Neuropsychol Adult. 2025-02-14;():1-14.

Occluder device, haemolysis and lipemic serum in a toddler with ventricular septal defect: connecting the dots.
pmid: 39950647
has PII: 17/12/e263526
doi: 10.1136/bcr-2024-263526
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mishra A
      type: Person
      first name: Aakanksha
      last name: Mishra
      member of: Pediatrics, Army Hospital Research and Referral, New Delhi, India.
  slot:
    index: 2
    item: Mishra A
      type: Person
      first name: Arvind
      last name: Mishra
      member of: Pediatrics, Army Hospital Research and Referral, New Delhi, India.
  slot:
    index: 3
    item: Tripathi P
      type: Person
      first name: Preeti
      last name: Tripathi
      member of: Pathology, Army Hospital Research and Referral, New Delhi, India.
  slot:
    index: 4
    item: Khera S
      type: Person
      first name: Sanjeev
      last name: Khera
      member of: Pediatrics, Army Hospital Research and Referral, New Delhi, India kherakherakhera@gmail.com.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2024-12-20
dp: 2024 Dec 20
created: 2025-2-14T07:54
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-20;17(12):.
volume: 17

Infective endocarditis presenting with intracranial bleed.
pmid: 39950641
has PII: 17/12/e263411
doi: 10.1136/bcr-2024-263411
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sharma S
      type: Person
      first name: Srishti
      last name: Sharma
      member of: Radiodiagnosis, All India Institute of Medical Sciences Patna, Patna, Bihar, India srishtidrsharma@gmail.com.
  slot:
    index: 2
    item: Rizwi K
      type: Person
      first name: Kashif
      last name: Rizwi
      member of: Radiodiagnosis, All India Institute of Medical Sciences Patna, Patna, Bihar, India.
  slot:
    index: 3
    item: Prasad SN
      type: Person
      first name: Surya Nandan
      last name: Prasad
      member of: Radiodiagnosis, All India Institute of Medical Sciences Patna, Patna, Bihar, India.
  slot:
    index: 4
    item: Haqe SE
      type: Person
      first name: Sumair Emadul
      last name: Haqe
      member of: Radiodiagnosis, All India Institute of Medical Sciences Patna, Patna, Bihar, India.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2024-12-22
dp: 2024 Dec 22
created: 2025-2-14T07:53
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-22;17(12):.
volume: 17

Ocular features in trichothiodystrophy.
pmid: 39950660
has PII: 17/12/e262504
doi: 10.1136/bcr-2024-262504
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Balaji A
      type: Person
      first name: Akshaya
      last name: Balaji
      member of: Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
  slot:
    index: 2
    item: Bari A
      type: Person
      first name: Aafreen
      last name: Bari
      member of: Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
  slot:
    index: 3
    item: Sharma N
      type: Person
      first name: Namrata
      last name: Sharma
      member of: Dr. R. P. Centre for Ophthalmic Sciences, AIIMS New Delhi, New Delhi, Delhi, India.
  slot:
    index: 4
    item: Agarwal T
      type: Person
      first name: Tushar
      last name: Agarwal
      member of: Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India drtushar@gmail.com.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2024-12-22
dp: 2024 Dec 22
created: 2025-2-14T07:54
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-22;17(12):.
volume: 17

Cavernous sinus dural arteriovenous fistula fed by a distal vertebral artery: a rare partial remnant of the persistent hypoglossal artery.
pmid: 39950661
has PII: 17/12/e263798
doi: 10.1136/bcr-2024-263798
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sato M
      type: Person
      first name: Masanori
      last name: Sato
      member of: Kagoshima University Graduate School of Medical and Dental Sciences Department of Neurosurgery, Kagoshima, Japan masanori-sato@umin.ac.jp.
  slot:
    index: 2
    item: Nishimuta Y
      type: Person
      first name: Yosuke
      last name: Nishimuta
      member of: Neurosurgery, Kagoshima City Hospital, Kagoshima, Kagoshima, Japan.
  slot:
    index: 3
    item: Tokimura H
      type: Person
      first name: Hiroshi
      last name: Tokimura
      member of: Neurosurgery, Kagoshima City Hospital, Kagoshima, Kagoshima, Japan.
  slot:
    index: 4
    item: Hanaya R
      type: Person
      first name: Ryosuke
      last name: Hanaya
      member of: Kagoshima University Graduate School of Medical and Dental Sciences Department of Neurosurgery, Kagoshima, Japan.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2024-12-20
dp: 2024 Dec 20
created: 2025-2-14T07:54
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 12
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
source: BMJ Case Rep. 2024-12-20;17(12):.
volume: 17

Trends in Operative Timing for Acute Traumatic Central Cord Syndrome: National Inpatient Sample Analysis 2013-2019.
pmid: 39950670
abstract: Retrospective cohort study.To analyze national trends in the management of acute traumatic central cord syndrome.Acute traumatic central cord syndrome (ATCCS) is the most common incomplete spinal cord injury. Initial management involves decompression and stabilization of the cervical spinal cord. On the basis of mixed literature regarding operative timing for ATCCS, we aimed to evaluate trends in early, late, and delayed surgery over the last 5-10 years and compare their respective outcomes.Data were obtained from the National Inpatient Sample (NIS) using specific ICD-10 codes. Baseline demographics, comorbidities, and outcomes were evaluated. These patients were grouped based on whether central cord syndrome (CCS) operative treatment was early (within 24h of admission), late (between 24 and 48h of admission), or delayed (after 48h of admission).A total of 21,265 patients underwent operative management for ATCCS; 16.7% received early operative management, 35.6% received late operative management, and 47.6% received delayed operative management. Compared with the total cohort, the delayed operative management group was more likely to contain patients with obesity (7.1% vs. 6.3%, P<0.001), chronic obstructive pulmonary disease (COPD) (12.9% vs. 11.1%, P<0.001), and diabetes mellitus (28.1% vs. 26.1%, P<0.001). Early operative management was more likely in patients with plegia (24.7% vs. 17%, P<0.001) and bowel/bladder dysfunction (14.6% vs. 9.5%, P<0.001) and was independently associated with lower rates of prolonged length of stay (LOS) (OR=0.71) and acute kidney injury (AKI) (OR=0.696).Our analysis of the trends in operative timing for ATCCS demonstrated an overall increase in the rate of early operative management and a decrease in the rate of delayed operative management. These findings mirror the current evolution of the literature on the topic. Nuances in early versus late outcomes should be used to help decision making related to operative timing in ATCCS.Level[cell cut: 2005 characters, first 2000 kept]
rights: Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 01933606-990000000-00437
doi: 10.1097/BSD.0000000000001770
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Gagliardi TA
      type: Person
      first name: Thomas A
      last name: Gagliardi
      member of: New York Medical College, School of Medicine, Valhalla, NY, USA.
  slot:
    index: 2
    item: Fleisher I
      type: Person
      first name: Ilan
      last name: Fleisher
      member of: New York Medical College, School of Medicine, Valhalla, NY, USA.
  slot:
    index: 3
    item: Lapow J
      type: Person
      first name: Justin
      last name: Lapow
      member of: New York Medical College, School of Medicine, Valhalla, NY, USA.
  slot:
    index: 4
    item: Spirollari E
      type: Person
      first name: Eris
      last name: Spirollari
      member of: New York Medical College, School of Medicine, Valhalla, NY, USA.
  slot:
    index: 5
    item: Sullivan T
      type: Person
      first name: Timothy
      last name: Sullivan
      member of: New York Medical College, School of Medicine, Valhalla, NY, USA.
  slot:
    index: 6
    item: Carr A
      type: Person
      first name: Alexis
      last name: Carr
      member of: New York Medical College, School of Medicine, Valhalla, NY, USA.
  slot:
    index: 7
    item: Berardino K
      type: Person
      first name: Kevin
      last name: Berardino
      member of: Department of Orthopaedic Surgery, Westchester Medical Center, Valhalla, NY, USA.
  slot:
    index: 8
    item: Kinon M
      type: Person
      first name: Merritt
      last name: Kinon
      member of: Department of Neurosurgery, Westchester Medical Center, Valhalla, NY, USA.
  slot:
    index: 9
    item: Patel H
      type: Person
      first name: Harshadkumar
      last name: Patel
      member of: Department of Orthopaedic Surgery, Westchester Medical Center, Valhalla, NY, USA.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T08:02
e ISSN: 2380-0194
has issn l: 2380-0186
has NLM journal title abbreviation: Clin Spine Surg
publication name: Clinical spine surgery
language: eng
has national library of medicine journal id: 101675083
derived from: NLM
has place of publication: United States
source: Clin Spine Surg. 2025-02-14;():.

Adjacent Segment Pathology After Short-Segment Posterior Lumbar Fusion: Postfusion Acceleration of Degeneration or Pre-Existing Degeneration?
pmid: 39950678
abstract: Retrospective review of 363 patients who underwent posterior lumbar fusion (PLF).Adjacent segment pathology (ASP) is a major and common event in patients who have undergone PLF. The objective of this study is to determine if ASP is due to accelerated processes following fusion or to pre-existing degeneration.ASP is defined as degenerative changes that occur 1-2 levels above or below the site of fusion in patients. The etiology of ASP is a topic of debate.Preoperative MRIs of 363 individuals who underwent PLF within L2-L3, L3-L4, and L4-L5 at the University of Kentucky between 2010 and 2020 were assessed for evidence of pre-existing degeneration. Measures of degeneration included Pfirrmann grade, modified Pfirrmann grade, disc height, and facet hyperintensity width. Demographic measures, including age, sex, smoking status, and BMI were also assessed.Throughout the follow-up period, 30.0% of patients evaluated were found to have ASP. 83.7% of these happened at the level below and 16.3% happened at the level above the fusion. Paired sample t testing indicated that only disc height was significantly different in the adjacent levels in those who developed ASP. There was no significant difference between the 2 levels for Pfirrmann grade, modified Pfirrmann grade, and facet T2 hyperintensity. Among degenerative measures, only disc height was different (lower) in the level below PLF compared with above, before fusion. Age, sex, and smoking status were not significantly different between those who developed ASP and those who did not (P=0.68, 0.81, 0.23, respectively).Analysis suggests that in patients undergoing PLF, pre-existing degeneration plays an insignificant role in the development of ASP, and that postoperative acceleration of degenerative changes still represents the primary etiology of ASP.Level III.
rights: Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 01933606-990000000-00438
doi: 10.1097/BSD.0000000000001762
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Horne F
      type: Person
      first name: Fielding
      last name: Horne
      member of: College of Medicine.
  slot:
    index: 2
    item: Louis Atherton M
      type: Person
      first name: Mara
      last name: Louis Atherton
      member of: College of Medicine.
  slot:
    index: 3
    item: Motiei-Langroudi R
      type: Person
      first name: Rouzbeh
      last name: Motiei-Langroudi
      member of: Department of Neurosurgery, University of Kentucky, Lexington, KY.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T08:03
e ISSN: 2380-0194
has issn l: 2380-0186
has NLM journal title abbreviation: Clin Spine Surg
publication name: Clinical spine surgery
language: eng
has national library of medicine journal id: 101675083
derived from: NLM
has place of publication: United States
source: Clin Spine Surg. 2025-02-14;():.

Bridging the gaps in AI performance evaluation in medical education.
pmid: 39950675
doi: 10.1080/0142159X.2025.2467301
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Dharmasaroja P
      type: Person
      first name: Permphan
      last name: Dharmasaroja
      member of: Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, Thailand.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T08:02
e ISSN: 1466-187X
has issn l: 0142-159X
has NLM journal title abbreviation: Med Teach
publication name: Medical teacher
language: eng
has national library of medicine journal id: 7909593
derived from: NLM
pg: 1
has place of publication: England
source: Med Teach. 2025-02-14;():1.

Reshaping Trauma Care: The Role of Personalized Resuscitation and Surgeon Leadership.
pmid: 39950676
has PII: 00019464-990000000-01105
doi: 10.1097/XCS.0000000000001264
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Ferrada P
      type: Person
      first name: Paula
      last name: Ferrada
      member of: Falls Church, VA.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T08:03
e ISSN: 1879-1190
has issn l: 1072-7515
has NLM journal title abbreviation: J Am Coll Surg
publication name: Journal of the American College of Surgeons
language: eng
has national library of medicine journal id: 9431305
derived from: NLM
has place of publication: United States
source: J Am Coll Surg. 2025-02-14;():.

Refining examiner alignment measures in OSCEs: A call for broader application and deeper insight.
pmid: 39950687
doi: 10.1080/0142159X.2025.2467281
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Supianto
      type: Person
      last name: Supianto
      member of: Universitas Sebelas Maret, Surakarta, Indonesia.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T08:03
e ISSN: 1466-187X
has issn l: 0142-159X
has NLM journal title abbreviation: Med Teach
publication name: Medical teacher
language: eng
has national library of medicine journal id: 7909593
derived from: NLM
pg: 1
has place of publication: England
source: Med Teach. 2025-02-14;():1.

Corrigendum: Water Science and Technology: Uncertainty in Evapotranspiration Inputs Impacts Hydrological Modeling, Mehnaza Akhter, et al.
pmid: 39950731
has PII: wst_2024_398
doi: 10.2166/wst.2024.398
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T08:33
ISSN: 0273-1223
has issn l: 0273-1223
issue: 3
has NLM journal title abbreviation: Water Sci Technol
publication name: Water science and technology : a journal of the International Association on Water Pollution Research
language: eng
has national library of medicine journal id: 9879497
derived from: NLM
pg: 332
has place of publication: England
source: Water Sci Technol. 2025-02;91(3):332.
volume: 91

Acquired Palmoplantar Keratoderma: Answer.
pmid: 39950768
has PII: 00000372-202503000-00014
doi: 10.1097/DAD.0000000000002909
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Rodriguez-Matta EM
      type: Person
      first name: Elisa M
      last name: Rodriguez-Matta
      member of: University of Puerto Rico School of Medicine, San Juan, PR.
  slot:
    index: 2
    item: Singer EM
      type: Person
      first name: Elisha M
      last name: Singer
      member of: Department of Dermatology, Mayo Clinic, Jacksonville, FL; and.
  slot:
    index: 3
    item: Sokumbi O
      type: Person
      first name: Olayemi
      last name: Sokumbi
      member of: Department of Dermatology, Mayo Clinic, Jacksonville, FL; and.Departments of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: 244
ending page: 245
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):244-245.
volume: 47

Multiple Erythematous Papules Over the Forehead After Botulinum Toxin Injection: Challenge.
pmid: 39950771
has PII: 00000372-202503000-00018
doi: 10.1097/DAD.0000000000002914
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Khoury DM
      type: Person
      first name: Dana M
      last name: Khoury
      member of: Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
  slot:
    index: 2
    item: Haddad F
      type: Person
      first name: Firas
      last name: Haddad
  slot:
    index: 3
    item: El Hawa M
      type: Person
      first name: Mariana
      last name: El Hawa
  slot:
    index: 4
    item: Abbas O
      type: Person
      first name: Ossama
      last name: Abbas
  slot:
    index: 5
    item: Rahal JA
      type: Person
      first name: Jihane Abou
      last name: Rahal
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: e31
ending page: e32
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):e31-e32.
volume: 47

A Knee-dle in a Haystack: A Rare Case of Angiomatoid Fibrous Histiocytoma on the Knee of a Child: Answer.
pmid: 39950769
has PII: 00000372-202503000-00015
doi: 10.1097/DAD.0000000000002900
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Singh P
      type: Person
      first name: Pritika
      last name: Singh
      member of: Penn State College of Medicine, Hershey, PA.
  slot:
    index: 2
    item: Deng E
      type: Person
      first name: Elen
      last name: Deng
      member of: Penn State College of Medicine, Hershey, PA.
  slot:
    index: 3
    item: Samson T
      type: Person
      first name: Thomas
      last name: Samson
      member of: Department of Plastic and Reconstructive Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA.
  slot:
    index: 4
    item: Mayes D
      type: Person
      first name: Dormosh
      last name: Mayes
      member of: Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA; and.
  slot:
    index: 5
    item: Helm T
      type: Person
      first name: Thomas
      last name: Helm
      member of: Department of Dermatology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: 246
ending page: 247
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):246-247.
volume: 47

Histopathology of Linear Lichen Planus.
pmid: 39950770
has PII: 00000372-202503000-00017
doi: 10.1097/DAD.0000000000002886
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Mehta N
      type: Person
      first name: Nikhil
      last name: Mehta
      member of: Department of Dermatology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
  slot:
    index: 2
    item: Ramam M
      type: Person
      first name: M
      last name: Ramam
      member of: Department of Dermatology and Venereology, All India Institute of Medical Sciences, Delhi, New Delhi, India.
  slot:
    index: 3
    item: Khaitan BK
      type: Person
      first name: Binod K
      last name: Khaitan
      member of: Fortis Hospital, Delhi, New Delhi, India.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: 249
ending page: 250
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):249-250.
volume: 47

Introduction: Minimally Invasive Spine Surgery of the Future, Don't Forget History's Lessons.
pmid: 39950777
has PII: 00006123-202503001-00001
doi: 10.1227/neu.0000000000003329
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Fessler RG
      type: Person
      first name: Richard G
      last name: Fessler
      member of: Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1524-4040
has issn l: 0148-396X
issue: 3S
has NLM journal title abbreviation: Neurosurgery
publication name: Neurosurgery
language: eng
has national library of medicine journal id: 7802914
derived from: NLM
starting page: S1
ending page: S2
has place of publication: United States
source: Neurosurgery. 2025-03-01;96(3S):S1-S2.
volume: 96

A Knee-dle in a Haystack: A Rare Case of Angiomatoid Fibrous Histiocytoma on the Knee of a Child: Challenge.
pmid: 39950773
has PII: 00000372-202503000-00020
doi: 10.1097/DAD.0000000000002899
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Singh P
      type: Person
      first name: Pritika
      last name: Singh
      member of: Penn State College of Medicine, Hershey, PA.
  slot:
    index: 2
    item: Deng E
      type: Person
      first name: Elen
      last name: Deng
      member of: Penn State College of Medicine, Hershey, PA.
  slot:
    index: 3
    item: Samson T
      type: Person
      first name: Thomas
      last name: Samson
      member of: Department of Plastic and Reconstructive Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA.
  slot:
    index: 4
    item: Mayes D
      type: Person
      first name: Dormosh
      last name: Mayes
      member of: Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA; and.
  slot:
    index: 5
    item: Helm T
      type: Person
      first name: Thomas
      last name: Helm
      member of: Department of Dermatology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: e36
ending page: e37
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):e36-e37.
volume: 47

Acquired Palmar Plantar Keratoderma: Challenge.
pmid: 39950772
has PII: 00000372-202503000-00019
doi: 10.1097/DAD.0000000000002908
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Rodriguez-Matta EM
      type: Person
      first name: Elisa M
      last name: Rodriguez-Matta
      member of: University of Puerto Rico School of Medicine, San Juan, PR.
  slot:
    index: 2
    item: Singer EM
      type: Person
      first name: Elisha M
      last name: Singer
      member of: Department of Dermatology, Mayo Clinic, Jacksonville, FL; and.
  slot:
    index: 3
    item: Sokumbi O
      type: Person
      first name: Olayemi
      last name: Sokumbi
      member of: Department of Dermatology, Mayo Clinic, Jacksonville, FL; and.Departments of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: e33
ending page: e35
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):e33-e35.
volume: 47

Multiple Erythematous Papules Over the Forehead After Botulinum Toxin Injection.
pmid: 39950767
has PII: 00000372-202503000-00013
doi: 10.1097/DAD.0000000000002915
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Khoury DM
      type: Person
      first name: Dana M
      last name: Khoury
      member of: Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
  slot:
    index: 2
    item: Haddad F
      type: Person
      first name: Firas
      last name: Haddad
  slot:
    index: 3
    item: El Hawa M
      type: Person
      first name: Mariana
      last name: El Hawa
  slot:
    index: 4
    item: Abbas O
      type: Person
      first name: Ossama
      last name: Abbas
  slot:
    index: 5
    item: Rahal JA
      type: Person
      first name: Jihane Abou
      last name: Rahal
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:03
e ISSN: 1533-0311
has issn l: 0193-1091
issue: 3
has NLM journal title abbreviation: Am J Dermatopathol
publication name: The American Journal of dermatopathology
language: eng
has national library of medicine journal id: 7911005
derived from: NLM
starting page: 242
ending page: 243
has place of publication: United States
source: Am J Dermatopathol. 2025-03-01;47(3):242-243.
volume: 47

Improving Primary Biliary Cholangitis Outcomes in the Evolving Landscape of Second-Line Therapies.
pmid: 39950799
doi: 10.1111/liv.70030
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Scaravaglio M
      type: Person
      first name: Miki
      last name: Scaravaglio
      member of: Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
  slot:
    index: 2
    item: Ronca V
      type: Person
      first name: Vincenzo
      last name: Ronca
      member of: Department of Biomedical Sciences, Humanitas University, Milan, Italy.Division of Internal Medicine and Hepatology, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy.
  slot:
    index: 3
    item: Carbone M
      type: Person
      first name: Marco
      last name: Carbone
      member of: Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.Hepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  slot:
    index: 4
    item: Invernizzi P
      type: Person
      first name: Pietro
      last name: Invernizzi
      member of: Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.Centre for Autoimmune Liver Diseases & Division of Gastroenterology, Fondazione IRCCS San Gerardo dei Tintori, ERN-RARE LIVER, Monza, Italy.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-03
dp: 2025 Mar
created: 2025-2-14T09:03
e ISSN: 1478-3231
has issn l: 1478-3223
issue: 3
has NLM journal title abbreviation: Liver Int
publication name: Liver international : official journal of the International Association for the Study of the Liver
language: eng
has national library of medicine journal id: 101160857
derived from: NLM
pg: e70030
has place of publication: United States
source: Liver Int. 2025-03;45(3):e70030.
volume: 45

Change in How We See Things: The Meningioma Story.
pmid: 39950815
has PII: 00006123-202503000-00001
doi: 10.1227/neu.0000000000003326
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kondziolka D
      type: Person
      first name: Douglas
      last name: Kondziolka
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T09:04
e ISSN: 1524-4040
has issn l: 0148-396X
issue: 3
has NLM journal title abbreviation: Neurosurgery
publication name: Neurosurgery
language: eng
has national library of medicine journal id: 7802914
derived from: NLM
starting page: 479
ending page: 480
has place of publication: United States
source: Neurosurgery. 2025-03-01;96(3):479-480.
volume: 96

A Prediction Nomogram for Long-Term Facial Nerve Function Following Large Vestibular Schwannoma Resection.
pmid: 39950810
abstract: The purpose of this study was to generate a nomogram for predicting long-term facial nerve (FN) function at 3 months following large vestibular schwannoma (VS) resection.Retrospective data were evaluated from patients who underwent VS resection from May 2014 to May 2023 at Huashan Hospital. The nomogram was conducted based on the results of univariate and multivariate logistic regression analysis of the risk factors for poor long-term FN function after VS resection.A total of 166 cases were finally included in this study. The univariate and multivariate logistic regression analysis showed that tumor size [P=0.022, odds ratio (OR): 1.11, 95% CI: 1.02-1.22), intraoperative stimulation threshold (ST) (P=0.005, OR: 12.17, 95% CI: 2.10-70.68), tumor type (P=0.009, OR: 7.46, 95% CI: 1.64-33.86) and 3-month postoperative HB grade (P=0.005, OR: 0.883, 95% CI: 0.062-12.61) were independent risk factors for poor long-term FN function. A nomogram was conducted based on these indicators, which demonstrated good discrimination and favorable calibration.A nomogram based on 4 indicators was conducted to predict long-term FN function at 3 months following large VS resection. Patients presented with little chance of long-term FN recovery are candidates for early intervention.
rights: Copyright © 2025 by Mutaz B. Habal, MD.
has PII: 00001665-990000000-02410
doi: 10.1097/SCS.0000000000011140
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Guan H
      type: Person
      first name: Haonan
      last name: Guan
      member of: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine.
  slot:
    index: 2
    item: Yu A
      type: Person
      first name: Aiping
      last name: Yu
      member of: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine.
  slot:
    index: 3
    item: Shi Z
      type: Person
      first name: Zhifeng
      last name: Shi
      member of: Department of Neurosurgery, Huashan Hospital, Fudan University.
  slot:
    index: 4
    item: Wang D
      type: Person
      first name: Daohe
      last name: Wang
      member of: Department of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
  slot:
    index: 5
    item: Ding W
      type: Person
      first name: Wei
      last name: Ding
      member of: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T09:04
e ISSN: 1536-3732
has issn l: 1049-2275
has NLM journal title abbreviation: J Craniofac Surg
publication name: The Journal of craniofacial surgery
language: eng
has national library of medicine journal id: 9010410
derived from: NLM
has place of publication: United States
source: J Craniofac Surg. 2025-02-14;():.

Developing a psychosocial competency framework for adult and older adult acute mental health inpatient care.
pmid: 39950837
abstract: Acute mental health inpatient settings care for those with acute and complex mental health needs. This study aimed to develop a psychosocial competency framework for use by multidisciplinary professional practitioners working in adult and older adult acute mental health inpatient settings.The competence framework was developed through an iterative developmental process. Initially, the relevant literature was reviewed to draft the framework. A multidisciplinary Expert Reference Group provided their expertise to refine and develop the framework and provide professional advice on areas with a weaker evidence base.A competency framework was produced and nine key areas of competency were developed; 'Basic knowledge of issues related to acute mental health inpatient care', 'Communication skills', 'Professional competences for all healthcare workers', 'Generic relationship competences', 'Assessment, formulation and planning', 'Structured care and intervention', 'Psychosocial interventions', 'Meta-competences', and 'Professional competences for organisations'.This competency framework will enable stakeholders to understand which competences are needed for high-quality acute mental health inpatient care provision. It can be used to underpin training packages in this field. Our framework has been recommended as a best-practice resource in the NHS England Acute Inpatient Mental Health Care guidance for adults and older adults.
rights: © 2025 The Author(s). Psychology and Psychotherapy: Theory, Research and Practice published by John Wiley & Sons Ltd on behalf of The British Psychological Society.
doi: 10.1111/papt.12575
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Wood L
      type: Person
      first name: Lisa
      last name: Wood
      member of: Acute and Rehabilitation Directorate, North East London NHS Foundation Trust, Goodmayes Hospital, Essex, UK.University College London, London, UK.
  slot:
    index: 2
    item: Williams C
      type: Person
      first name: Claire
      last name: Williams
      member of: Acute and Rehabilitation Directorate, North East London NHS Foundation Trust, Goodmayes Hospital, Essex, UK.
  slot:
    index: 3
    item: Luxon L
      type: Person
      first name: Leah
      last name: Luxon
      member of: Acute and Rehabilitation Directorate, North East London NHS Foundation Trust, Goodmayes Hospital, Essex, UK.
  slot:
    index: 4
    item: Kumary A
      type: Person
      first name: Ajvir
      last name: Kumary
      member of: Acute and Rehabilitation Directorate, North East London NHS Foundation Trust, Goodmayes Hospital, Essex, UK.
  slot:
    index: 5
    item: Roth A
      type: Person
      first name: Anthony
      last name: Roth
      member of: University College London, London, UK.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T09:23
e ISSN: 2044-8341
has issn l: 1476-0835
has NLM journal title abbreviation: Psychol Psychother
publication name: Psychology and psychotherapy
language: eng
has national library of medicine journal id: 101135751
derived from: NLM
has place of publication: England
source: Psychol Psychother. 2025-02-14;():.

Local tumor control and neurological outcomes after surgery for spinal hemangioblastomas in sporadic and Von-Hippel-Lindau Disease: A multicenter study.
pmid: 39950840
abstract: Spinal hemangioblastomas (sHBs) are rare vascular tumors with significant neurological implications. Their management, particularly in von Hippel-Lindau (VHL) disease, remains challenging due to recurrence and functional decline. Timely identification and intervention are critical for optimal outcomes.This international, multicenter retrospective cohort study included 357 patients (199 VHL-associated, 158 sporadic) from 13 neuro-oncological centers. Clinical and imaging data were analyzed to assess progression-free survival (PFS) and functional outcomes using the Modified McCormick Scale (mMCS) at 12 months. Secondary analyses identified factors associated with VHL disease in sHBs.Complete resection (CR) was achieved in 87.7% of cases, leading to significantly improved PFS at 72 months (sporadic: 95.1%, VHL-associated: 91.1%; HR: 0.18, 95%CI: 0.08-0.4). Multivariable analysis identified predictors of unfavorable outcomes at 12 months: Preoperative mMCS ≥2 (OR: 5.17, p=0.008), intramedullary tumor location (OR: 9.48, p=0.01), and preoperative bleeding (OR: 31.12, p=0.02). Factors independently associated with VHL disease in sHBs included non-cervical tumor location (OR: 2.08, p=0.004), intramedullary growth (OR: 2.39, p<0.001), and age <43 years (OR: 3.24, p<0.001). Functional improvements were observed in most patients, particularly those with sporadic sHBs.Complete surgical resection is essential for long-term tumor control and favorable functional outcomes in both sporadic and VHL-associated sHBs. Early intervention, particularly in mild symptomatic and progressive cases, before neurological deterioration or hemorrhage, optimizes recovery. This study, the largest of its kind in a multicentric international setting, provides robust evidence to guide the management of both sporadic and VHL-associated sHBs.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.
has PII: 8015463
doi: 10.1093/neuonc/noaf041
creator: OrderedList
  length: 37
  slot:
    index: 1
    item: Wach J
      type: Person
      first name: Johannes
      last name: Wach
      member of: Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.Comprehensive Cancer Center Central Germany, Partner Site Leipzig, Leipzig, Germany.
  slot:
    index: 2
    item: Basaran AE
      type: Person
      first name: Alim Emre
      last name: Basaran
      member of: Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.Comprehensive Cancer Center Central Germany, Partner Site Leipzig, Leipzig, Germany.
  slot:
    index: 3
    item: Vychopen M
      type: Person
      first name: Martin
      last name: Vychopen
      member of: Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.Comprehensive Cancer Center Central Germany, Partner Site Leipzig, Leipzig, Germany.
  slot:
    index: 4
    item: Tihan T
      type: Person
      first name: Tarik
      last name: Tihan
      member of: Division of Neuropathology, UCSF School of Medicine, San Francisco, California, USA.Department of Pathology, Miller School of Medicine, University of Miami, Florida, USA.
  slot:
    index: 5
    item: Wostrack M
      type: Person
      first name: Maria
      last name: Wostrack
      member of: Department of Neurosurgery, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Germany.
  slot:
    index: 6
    item: Butenschoen VM
      type: Person
      first name: Vicki M
      last name: Butenschoen
      member of: Department of Neurosurgery, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Germany.
  slot:
    index: 7
    item: Meyer B
      type: Person
      first name: Bernhard
      last name: Meyer
      member of: Department of Neurosurgery, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Germany.
  slot:
    index: 8
    item: Siller S
      type: Person
      first name: Sebastian
      last name: Siller
      member of: Department of Neurosurgery, University Hospital, University of Regensburg, 93053 Regensburg, Germany.
  slot:
    index: 9
    item: Schmidt NO
      type: Person
      first name: Nils Ole
      last name: Schmidt
      member of: Department of Neurosurgery, University Hospital, University of Regensburg, 93053 Regensburg, Germany.
  slot:
    index: 10
    item: Onken J
      type: Person
      first name: Julia
      last name: Onken
      member of: Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  slot:
    index: 11
    item: Vajkoczy P
      type: Person
      first name: Peter
      last name: Vajkoczy
      member of: Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  slot:
    index: 12
    item: Santos AN
      type: Person
      first name: Alejandro N
      last name: Santos
      member of: Department of Neurosurgery and Spine Surgery, University Hospital Essen, Germany.Department of Neurosurgery, Royal Adelaide Hospital, Australia.
  slot:
    index: 13
    item: Rauschenbach L
      type: Person
      first name: Laurèl
      last name: Rauschenbach
      member of: Department of Neurosurgery and Spine Surgery, University Hospital Essen, Germany.DKFZ-Division Translational Neurooncology at the WTZ, DKTK Partner Site, University Hospital Essen, Germany.
  slot:
    index: 14
    item: Dammann P
      type: Person
      first name: Philipp
      last name: Dammann
      member of: Department of Neurosurgery and Spine Surgery, University Hospital Essen, Germany.
  slot:
    index: 15
    item: Sure U
      type: Person
      first name: Ulrich
      last name: Sure
      member of: Department of Neurosurgery and Spine Surgery, University Hospital Essen, Germany.
  slot:
    index: 16
    item: Klingler JH
      type: Person
      first name: Jan-Helge
      last name: Klingler
      member of: Department of Neurosurgery, Medical Center - University of Freiburg, Germany.
  slot:
    index: 17
    item: Doria-Medina R
      type: Person
      first name: Roberto
      last name: Doria-Medina
      member of: Department of Neurosurgery, Medical Center - University of Freiburg, Germany.
  slot:
    index: 18
    item: Beck J
      type: Person
      first name: Jürgen
      last name: Beck
      member of: Department of Neurosurgery, Medical Center - University of Freiburg, Germany.
  slot:
    index: 19
    item: Blaß BI
      type: Person
      first name: Bianca-Ioana
      last name: Blaß
      member of: Department of Neurosurgery, Medical Center - University of Freiburg, Germany.
  slot:
    index: 20
    item: Gizaw CJ
      type: Person
      first name: Christine Juliane
      last name: Gizaw
      member of: Department of Neurosurgery, Medical Center - University of Freiburg, Germany.
  slot:
    index: 21
    item: Hohenhaus R
      type: Person
      first name: Romina
      last name: Hohenhaus
      member of: Department of Neurosurgery, Medical Center - University of Freiburg, Germany.
  slot:
    index: 22
    item: Krieg S
      type: Person
      first name: Sandro
      last name: Krieg
      member of: Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.Medical Faculty, Heidelberg University, Heidelberg 69120, Germany.
  slot:
    index: 23
    item: Alhalabi OT
      type: Person
      first name: Obada T
      last name: Alhalabi
      member of: Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.Medical Faculty, Heidelberg University, Heidelberg 69120, Germany.
  slot:
    index: 24
    item: Klein L
      type: Person
      first name: Lukas
      last name: Klein
      member of: Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.Medical Faculty, Heidelberg University, Heidelberg 69120, Germany.
  slot:
    index: 25
    item: Thomé C
      type: Person
      first name: Claudius
      last name: Thomé
      member of: Department of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
  slot:
    index: 26
    item: Kögl N
      type: Person
      first name: Nikolaus
      last name: Kögl
      member of: Department of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
  slot:
    index: 27
    item: Kunert P
      type: Person
      first name: Przemyslaw
      last name: Kunert
      member of: Department of Neurosurgery, Medical University of Warsaw, Poland.
  slot:
    index: 28
    item: Czernicki T
      type: Person
      first name: Tomasz
      last name: Czernicki
      member of: Department of Neurosurgery, Medical University of Warsaw, Poland.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T09:23
e ISSN: 1523-5866
has issn l: 1522-8517
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
has place of publication: England
source: Neuro Oncol. 2025-02-14;():.

Newborn screening for inborn errors of immunity in Brazil.
pmid: 39950838
doi: 10.1111/pai.70047
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Aranda CS
      type: Person
      first name: Carolina Sanchez
      last name: Aranda
      member of: Division of Allergy, Clinical Immunology, and Rheumatology, Department of Pediatrics, Federal University of São Paulo Medical (UNIFESP) Escola Paulista de Medicina, São Paulo, Brazil.
  slot:
    index: 2
    item: Pimentel MG
      type: Person
      first name: Mariana Gouveia-Pereira
      last name: Pimentel
      member of: Instituto Jo Clemente and Division of Allergy, Clinical Immunology, and Rheumatology, Department of Pediatrics, Federal University of São Paulo (UNIFESP)--Escola Paulista de Medicina, São Paulo, Brazil.
  slot:
    index: 3
    item: Guimaraes RR
      type: Person
      first name: Rafaela Rola
      last name: Guimaraes
      member of: Division of Allergy, Clinical Immunology, and Rheumatology, Department of Pediatrics, Federal University of São Paulo Medical (UNIFESP) Escola Paulista de Medicina, São Paulo, Brazil.
  slot:
    index: 4
    item: Fernandes JF
      type: Person
      first name: Juliana Folloni
      last name: Fernandes
      member of: Instituto de Tratamento Do Cancer Infantil (ITACI), University of Sao Paulo, São Paulo, Brazil.
  slot:
    index: 5
    item: Rizzo MCFV
      type: Person
      first name: Maria Candida Faria Varanda
      last name: Rizzo
      member of: Division of Allergy, Clinical Immunology, and Rheumatology, Department of Pediatrics, Federal University of São Paulo Medical (UNIFESP) Escola Paulista de Medicina, São Paulo, Brazil.
  slot:
    index: 6
    item: Ishizuka E
      type: Person
      first name: Edson
      last name: Ishizuka
      member of: Immunogenic Laboratories, São Paulo, Brazil.
  slot:
    index: 7
    item: de Oliveira Junior EB
      type: Person
      first name: Edgar Borges
      last name: de Oliveira Junior
      member of: Immunogenic Laboratories, São Paulo, Brazil.
  slot:
    index: 8
    item: Hadachi SM
      type: Person
      first name: Sonia Marchezi
      last name: Hadachi
      member of: Instituto Jo Clemente, Sao Paulo, Brazil.
  slot:
    index: 9
    item: Hayashi GY
      type: Person
      first name: Giselle Yuri
      last name: Hayashi
      member of: Instituto Jo Clemente, Sao Paulo, Brazil.
  slot:
    index: 10
    item: de Andrade CEF
      type: Person
      first name: Carlos Eugênio Fernandez
      last name: de Andrade
      member of: Department of Health, The City of São Paulo, São Paulo, Brazil.
  slot:
    index: 11
    item: de Marco Mauro AM
      type: Person
      first name: Athenê Maria
      last name: de Marco Mauro
      member of: Department of Health, The City of São Paulo, São Paulo, Brazil.
  slot:
    index: 12
    item: Sole D
      type: Person
      first name: Dirceu
      last name: Sole
      member of: Division of Allergy, Clinical Immunology, and Rheumatology, Department of Pediatrics, Federal University of São Paulo Medical (UNIFESP) Escola Paulista de Medicina, São Paulo, Brazil.
  slot:
    index: 13
    item: Condino-Neto A
      type: Person
      first name: Antonio
      last name: Condino-Neto
      member of: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Instituto Jo Clemente, and Immunogenic Laboratories, São Paulo, Brazil.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T09:23
e ISSN: 1399-3038
has issn l: 0905-6157
issue: 2
has NLM journal title abbreviation: Pediatr Allergy Immunol
publication name: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
language: eng
has national library of medicine journal id: 9106718
derived from: NLM
pg: e70047
has place of publication: England
source: Pediatr Allergy Immunol. 2025-02;36(2):e70047.
volume: 36

Editorial comment on Diversity of complementary diet and early food allergy risk .
pmid: 39950844
doi: 10.1111/pai.70042
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Silva G
      type: Person
      first name: Gonçalo
      last name: Silva
      member of: EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal.
  slot:
    index: 2
    item: Eigenmann P
      type: Person
      first name: Philippe
      last name: Eigenmann
      member of: Pediatric Allergy Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
  slot:
    index: 3
    item: Peters R
      type: Person
      first name: Rachel
      last name: Peters
      member of: Murdoch Children's Research Institute, Melbourne, Victoria, Australia.Department of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T09:23
e ISSN: 1399-3038
has issn l: 0905-6157
issue: 2
has NLM journal title abbreviation: Pediatr Allergy Immunol
publication name: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
language: eng
has national library of medicine journal id: 9106718
derived from: NLM
pg: e70042
has place of publication: England
source: Pediatr Allergy Immunol. 2025-02;36(2):e70042.
volume: 36

Identification of Urinary Metabolic Biomarkers for H3K27M Mutation Diagnosis in Brainstem Gliomas.
pmid: 39950856
abstract: Brainstem gliomas (BSGs) harboring a histone 3 lysine27-to-methionine (H3K27M) mutation represent one of the deadliest brain tumors with a dismal prognosis, as they exhibit a much worse response to therapy compared to the wildtype BSGs. Early non-invasive recognition of the H3K27M mutation is paramount for clinical decision-making in treating BSGs.Plasma and urine samples were prospectively collected from BSG patients before biopsy or surgical resection and were chronologically divided into discovery, test, and validation cohorts. Utilizing the discovery and test cohort samples, an untargeted metabolomic strategy was exploited to identify candidate metabolite biomarkers, related to the H3K27M mutation. The candidate biomarkers were validated in the validation cohort with a targeted metabolomic method.Differential metabolomic profiles were detected between the H3K27M-mutant and wild-type BSGs in both the plasma and urine, the metabolomic changes were more dramatic in urine than in plasma. After rigorous screening for candidate biomarkers and validation with a targeted metabolomic approach, three metabolites, nomilin, Lys-Leu, and hawkinsin, emerged as significantly elevated biomarkers in H3K27M-mutant BSG urine samples. The biomarker panel combining the three metabolites had a diagnostic area under the curve (AUC) of approximately 75%. Furthermore, the biomarker panel improved the prediction accuracy of radiomics/clinical models to an AUC value high as 93.38%.A urinary metabolite biomarker panel that exhibited high accuracy for non-invasive prediction of the H3K27M mutation status in BSG patients was identified. This panel has the potential to improve the predictive performance of current radiomics models or clinical features.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 8015462
doi: 10.1093/neuonc/noaf038
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Li X
      type: Person
      first name: Xiaoou
      last name: Li
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 2
    item: Sun W
      type: Person
      first name: Wei
      last name: Sun
      member of: Proteomics Center, Core Facility of Instrument, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
  slot:
    index: 3
    item: Guo Z
      type: Person
      first name: Zhengguang
      last name: Guo
      member of: Proteomics Center, Core Facility of Instrument, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
  slot:
    index: 4
    item: Qi F
      type: Person
      first name: Feng
      last name: Qi
      member of: Proteomics Center, Core Facility of Instrument, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
  slot:
    index: 5
    item: Li T
      type: Person
      first name: Tian
      last name: Li
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 6
    item: Wang Y
      type: Person
      first name: Yujin
      last name: Wang
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 7
    item: Zhang M
      type: Person
      first name: Mingxin
      last name: Zhang
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 8
    item: Wang A
      type: Person
      first name: Aiwei
      last name: Wang
      member of: Proteomics Center, Core Facility of Instrument, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
  slot:
    index: 9
    item: Jiang Z
      type: Person
      first name: Zhuang
      last name: Jiang
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 10
    item: Xie L
      type: Person
      first name: Luyang
      last name: Xie
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 11
    item: Mai Y
      type: Person
      first name: Yiying
      last name: Mai
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 12
    item: Wang Y
      type: Person
      first name: Yi
      last name: Wang
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 13
    item: Wu Z
      type: Person
      first name: Zhen
      last name: Wu
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 14
    item: Ji N
      type: Person
      first name: Nan
      last name: Ji
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 15
    item: Zhang Y
      type: Person
      first name: Yang
      last name: Zhang
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  slot:
    index: 16
    item: Zhang L
      type: Person
      first name: Liwei
      last name: Zhang
      member of: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T09:24
e ISSN: 1523-5866
has issn l: 1522-8517
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
has place of publication: England
source: Neuro Oncol. 2025-02-14;():.

Request for residual bovine blood samples.
pmid: 39950871
doi: 10.1002/vetr.5257
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Knuepfer E
      type: Person
      first name: Ellen
      last name: Knuepfer
      member of: Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:33
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 157
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):157.
volume: 196

Impact of leukoreduction on the metabolome of ovine packed red blood cells during refrigerated storage.
pmid: 39950860
abstract: Blood transfusion is a life-saving intervention for many species of veterinary interest, including sheep. Despite extensive research on the impact of refrigerated storage of packed red blood cells (pRBC) in humans, research on the quality of stored ovine blood is limited and storage guidelines are mostly informed by studies in humans. Human pRBC are currently stored without residual white blood cells, following selective removal of the leukocytes by filtration (leukoreduction). This process delays the onset and mitigates the progression of the storage lesion, a series of molecular changes that RBC undergo as a function of storage duration. However, leukoreduction of ovine pRBC is not routinely performed.Here we performed metabolomics analyses of non-leukoreduced (nLR) and LR pRBC from six sheep. Units were stored under standard veterinary blood bank conditions (4°C) for up to 42 days and sterilely sampled weekly for metabolomics analyses of cells and supernatants.LR-pRBC showed significantly lower levels of mono-, di- and tri-carboxylates in both the cellular and supernatant compartments, and slower accumulation of lactate and immunomodulatory succinate, fumarate and malate. The presence of residual white blood cells in the units accelerated the consumption of glucose from the media, with no increase in detectable high energy phosphate compounds (AMP). nLR showed a higher degree of purine breakdown and deamination products, (hypoxanthine, xanthine and allantoate). Elevated free fatty acids in nLR RBC are consistent with increased lipid peroxidation and lipolysis. Strong sex dimorphism was observed across all samples, independently of storage duration or leukoreduction.Leukoreduction of ovine pRBC delays the onset and mitigates the metabolic storage lesion to central energy and redox metabolism, while almost completely abrogating the accumulation of carboxylates in stored units.
has PII: BloodTransfus.830
doi: 10.2450/BloodTransfus.830
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Miglio A
      type: Person
      first name: Arianna
      last name: Miglio
      member of: Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
  slot:
    index: 2
    item: Di Tommaso M
      type: Person
      first name: Morena
      last name: Di Tommaso
      member of: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
  slot:
    index: 3
    item: Rocconi F
      type: Person
      first name: Francesca
      last name: Rocconi
      member of: Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
  slot:
    index: 4
    item: Reisz JH
      type: Person
      first name: Julie Haines
      last name: Reisz
      member of: Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States of America.
  slot:
    index: 5
    item: D'Alessandro A
      type: Person
      first name: Angelo
      last name: D'Alessandro
      member of: Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States of America.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-06
dp: 2025 Feb 06
created: 2025-2-14T09:32
e ISSN: 2385-2070
has issn l: 1723-2007
has NLM journal title abbreviation: Blood Transfus
publication name: Blood transfusion = Trasfusione del sangue
language: eng
has national library of medicine journal id: 101237479
derived from: NLM
has place of publication: Italy
source: Blood Transfus. 2025-02-06;():.

Unveiling Disparities in Patient Rights Awareness and Practice: Insights From Artificial Neural Networks.
pmid: 39950869
abstract: High-quality universal health care coverage for all patients is the common theme in patient rights. However, pertinent investigations on this topic within the context of Jordanian health care are absent. This systematic review, coupled with a pooled artificial intelligence analysis of the data in retrieved studies, paves the way for such research by pooling data sets sourced from across the Middle East and North Africa (MENA) region.National Library of Medicine (NLM), through its secondary database of primary literature (PubMed), was queried with the terms Patient and Rights in April 2024. Quantitative surveys from MENA containing individual item assessments mapped to 1 of the 7 domains of Jordan National Patient Rights Charter were pooled. Finally, factors extracted for all studies were then used to build an artificial neural network (ANN) to test the hypothesis that information asymmetry in both awareness and practice of patient rights exist even among health care providers.A total of 8 studies with 131 survey items were identified in the MENA region. All items tested either knowledge (awareness) or practice (implementation) of respondents regards patient rights except for 25 items in one study which measured both. ANN converged to a best net of multilayer feedforward with 3 hidden nodes. Patient right domain, from Jordanian Patient Rights Charter, ranked first and respondent type second as most important among the variables. However, there was huge and statistically significant asymmetry between students 0.602 (0.499 to 0.853), patients 0.627 (0.518 to 0.636), and nurses 0.492 (0.340 to 0.786) on one side and clinicians 1.166 (1.025 to 1.258) on the other side in the ANN model (both paired t test and Wilcoxon signed rank test P<0.0001) for any pairwise comparisons.Jordan National Patient Charter can fit any patient right item one could think of in the infinite space of patient rights. Huge information asymmetry exists in both awareness and implementation between [cell cut: 2085 characters, first 2000 kept]
rights: Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 01209203-990000000-00312
doi: 10.1097/PTS.0000000000001326
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Saadah LM
      type: Person
      first name: Loai M
      last name: Saadah
      member of: Department of Clinical Pharmacy, Faculty of Pharmacy, Applied Science Private University.
  slot:
    index: 2
    item: Alnatour DB
      type: Person
      first name: Dalal B
      last name: Alnatour
      member of: Department of Clinical Pharmacy, Faculty of Pharmacy, Applied Science Private University.
  slot:
    index: 3
    item: Hadidi MS
      type: Person
      first name: Mumen S
      last name: Hadidi
      member of: Patient Protection Coalition, Amman, Jordan.
  slot:
    index: 4
    item: Samara FF
      type: Person
      first name: Fadia F
      last name: Samara
      member of: Patient Protection Coalition, Amman, Jordan.
  slot:
    index: 5
    item: Shakhshir SS
      type: Person
      first name: Sana S
      last name: Shakhshir
      member of: Patient Protection Coalition, Amman, Jordan.
  slot:
    index: 6
    item: Alnsour WM
      type: Person
      first name: Wafa'a M
      last name: Alnsour
      member of: Patient Protection Coalition, Amman, Jordan.
  slot:
    index: 7
    item: Saket MK
      type: Person
      first name: Maisa K
      last name: Saket
      member of: Patient Protection Coalition, Amman, Jordan.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-17
dp: 2025 Feb 17
created: 2025-2-14T09:33
e ISSN: 1549-8425
has issn l: 1549-8417
has NLM journal title abbreviation: J Patient Saf
publication name: Journal of patient safety
language: eng
has national library of medicine journal id: 101233393
derived from: NLM
has place of publication: United States
source: J Patient Saf. 2025-02-17;():.

Helping children through pet bereavement.
pmid: 39950879
doi: 10.1002/vetr.5239
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Loeb J
      type: Person
      first name: Josh
      last name: Loeb
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 142
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):142.
volume: 196

Plans to reduce dairy cow lameness by 2044.
pmid: 39950880
doi: 10.1002/vetr.5234
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 136
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):136.
volume: 196

More funding needed to police XL bully ban.
pmid: 39950881
doi: 10.1002/vetr.5231
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Loeb J
      type: Person
      first name: Josh
      last name: Loeb
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 134
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):134.
volume: 196

Effects of occupational tasks and personal protective equipment on static and functional balance among career firefighters.
pmid: 39950875
abstract: Musculoskeletal injuries are commonly incurred by firefighters. Most injuries are attributable to overexertion, fall, slip, and trip mechanisms. These injuries may be caused by many factors, including the independent and collective effects of wearing personal protective equipment (PPE) and fatigue induced by performing occupational-tasks. The purpose of this study was to investigate the effect of PPE and fire-suppression tasks on static and functional balance among firefighters. 32 healthy male career structural firefighters (Age: 31.8 ± 9.5 yr) participated in this study. Statistical analyses revealed significant differences in static balance measures pre versus post-work in PPE p ≤ 0.009, and functional balance outcomes pre-work in station uniform versus pre-work in PPE p < 0.001. PPE negatively affected firefighters' functional balance, whereas occupational tasks negatively affected static balance outcomes. These findings highlight the importance of utilising countermeasures to combat occupational fatigue-induced decrements in neuromuscular function to reduce injury risk among structural firefighters.
doi: 10.1080/00140139.2025.2466010
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kis P
      type: Person
      first name: Petra
      last name: Kis
      member of: Health and Human Performance School of Kinesiology, Oklahoma State University, Stillwater, OK, USA.
  slot:
    index: 2
    item: Abel M
      type: Person
      first name: Mark
      last name: Abel
      member of: First Responder Research Laboratory, University of Kentucky, Lexington, KY, USA.
  slot:
    index: 3
    item: Joyner B
      type: Person
      first name: Barry
      last name: Joyner
      member of: Department of Health Sciences and Kinesiology, Georgia Southern University, Statesboro, GA, USA.
  slot:
    index: 4
    item: Munkasy B
      type: Person
      first name: Barry
      last name: Munkasy
      member of: Department of Health Sciences and Kinesiology, Georgia Southern University, Statesboro, GA, USA.
  slot:
    index: 5
    item: Melton B
      type: Person
      first name: Bridget
      last name: Melton
      member of: Department of Health Sciences and Kinesiology, Georgia Southern University, Statesboro, GA, USA.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T09:33
e ISSN: 1366-5847
has issn l: 0014-0139
has NLM journal title abbreviation: Ergonomics
publication name: Ergonomics
language: eng
has national library of medicine journal id: 0373220
rights holder: Musculoskeletal injuries are common among structural firefighters and often caused by overexertion, slip, trip, and fall mechanisms; thus, adequate neuromuscular function is crucial to reduce injury risk. There are various factors that affect balance among firefighters while on duty. For example, static balance outcomes are impaired by performing occupational tasks. Although personal protective equipment plays an essential role in safety, it has deleterious effects on firefighters’ functional balance.
derived from: NLM
starting page: 1
ending page: 9
has place of publication: England
source: Ergonomics. 2025-02-14;():1-9.

Looking for the wins.
pmid: 39950882
doi: 10.1002/vetr.5229
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Jarvis S
      type: Person
      first name: Suzanne
      last name: Jarvis
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 131
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):131.
volume: 196

CMA sets out its emerging views.
pmid: 39950884
doi: 10.1002/vetr.5230
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Loeb J
      type: Person
      first name: Josh
      last name: Loeb
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
starting page: 132
ending page: 133
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):132-133.
volume: 196

Schmallenberg virus re-emerges in lambs and calves in Northern Ireland.
pmid: 39950883
doi: 10.1002/vetr.5249
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: e5249
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):e5249.
volume: 196

Liquid channel tunable lens for phased-based ultrasonic beamforminga).
pmid: 39950888
abstract: This work reports on the design and characterization of a tunable lens with a planar aperture that employs liquid channels to perform phase-based beamforming. The desired phase patterns are produced using specific speed-of-sound profiles and can be flexibly configured for a range of frequencies and beam types without changes to its shape or structure. Measurements of the fields show that the lens performs comparably to stepped designs, such as the fraxicon, for a range of focal configurations. The planar geometry and reconfigurable phasing provide for a range of possible applications from nearfield trapping to imaging and therapeutics.
rights: © 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
has PII: 3336066
doi: 10.1121/10.0035926
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Rostami S
      type: Person
      first name: Sina
      last name: Rostami
      member of: Department of Physics and Astronomy, The University of Mississippi, University, Mississippi 38677, USA.
  slot:
    index: 2
    item: Mobley J
      type: Person
      first name: Joel
      last name: Mobley
      member of: Department of Physics and Astronomy, The University of Mississippi, University, Mississippi 38677, USA.Jamie Whitten National Center for Physical Acoustics, The University of Mississippi, University, Mississippi 38677, USAsrostami@olemiss.edu, jmobley@olemiss.edu.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-01
dp: 2025 Feb 01
created: 2025-2-14T09:43
e ISSN: 2691-1191
has issn l: 2691-1191
issue: 2
has NLM journal title abbreviation: JASA Express Lett
publication name: JASA express letters
language: eng
has national library of medicine journal id: 101775177
derived from: NLM
has place of publication: United States
source: JASA Express Lett. 2025-02-01;5(2):.
volume: 5

Benefits of a broad veterinary education.
pmid: 39950885
doi: 10.1002/vetr.5252
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Alexander D
      type: Person
      first name: Dominic
      last name: Alexander
      member of: Inspiral, Banner Cottage, Cross Keys, Hereford, HR1 3NN.
  slot:
    index: 2
    item: Palmer EL
      type: Person
      first name: Elaine Louise
      last name: Palmer
      member of: Chelsea and Westminster NHS Trust and The Vulva and Menopause Clinic, 167-169 Great Portland Street, London, W1W 5PF.
  slot:
    index: 3
    item: Mercer M
      type: Person
      first name: Maria
      last name: Mercer
      member of: Belmont Vets, 94 Belmont Road, Hereford, HR2 7JS.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
starting page: 153
ending page: 154
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):153-154.
volume: 196

Sonar micro-Doppler effect induced by ship oscillatory motion in waves: Phenomenon, model, and experimentation.
pmid: 39950886
abstract: Traditional research attributes the modulated sidebands of ship radiation line-spectrum signals to reflections off rough ocean surfaces, but the Doppler effect caused by vessel motion may also contribute. This study establishes a micro-Doppler signal model based on wave-induced ship swaying, explaining that this phenomenon arises from the ship oscillatory motion in waves. The sea trial results demonstrate that the peak wave frequency, the frequency of ship micro-motions, and the micro-Doppler characteristic frequency recorded by the beacon exhibit a sudden frequency shift occurring synchronously from 0.075 to 0.115 Hz, thereby verifying the validity of the proposed model.
rights: © 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
has PII: 3336063
doi: 10.1121/10.0035914
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wang M
      type: Person
      first name: Minhao
      last name: Wang
      member of: National Key Laboratory of Underwater Acoustic Technology, Harbin Engineering University, Harbin, 150001, China.Key Laboratory of Marine Information Acquisition and Security (Harbin Engineering University), Ministry of Industry and Information Technology, Harbin, 150001, China.College of Underwater Acoustic Engineering, Harbin Engineering University, Harbin, 150001, China.
  slot:
    index: 2
    item: Zheng C
      type: Person
      first name: Cuie
      last name: Zheng
      member of: National Key Laboratory of Underwater Acoustic Technology, Harbin Engineering University, Harbin, 150001, China.Qingdao Innovation and Development Base, Harbin Engineering University, Qingdao, 266000, Chinawangminhao@hrbeu.edu.cn, zhengcuie@hrbeu.edu.cn, sundajun@hrbeu.edu.cn, xu_jian1999@163.com.
  slot:
    index: 3
    item: Sun D
      type: Person
      first name: Dajun
      last name: Sun
      member of: National Key Laboratory of Underwater Acoustic Technology, Harbin Engineering University, Harbin, 150001, China.Key Laboratory of Marine Information Acquisition and Security (Harbin Engineering University), Ministry of Industry and Information Technology, Harbin, 150001, China.College of Underwater Acoustic Engineering, Harbin Engineering University, Harbin, 150001, China.
  slot:
    index: 4
    item: Xu J
      type: Person
      first name: Jian
      last name: Xu
      member of: National Key Laboratory of Underwater Acoustic Technology, Harbin Engineering University, Harbin, 150001, China.Key Laboratory of Marine Information Acquisition and Security (Harbin Engineering University), Ministry of Industry and Information Technology, Harbin, 150001, China.College of Underwater Acoustic Engineering, Harbin Engineering University, Harbin, 150001, China.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-01
dp: 2025 Feb 01
created: 2025-2-14T09:43
e ISSN: 2691-1191
has issn l: 2691-1191
issue: 2
has NLM journal title abbreviation: JASA Express Lett
publication name: JASA express letters
language: eng
has national library of medicine journal id: 101775177
derived from: NLM
has place of publication: United States
source: JASA Express Lett. 2025-02-01;5(2):.
volume: 5

RCVS concerns investigation system explained.
pmid: 39950892
doi: 10.1002/vetr.5253
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Belton L
      type: Person
      first name: Linda
      last name: Belton
      member of: RCVS, The Cursitor, 38 Chancery Lane, London, WC2A 1EN.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
starting page: 154
ending page: 155
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):154-155.
volume: 196

Frequency band analysis and comparison of localisation techniques for drones using microphone array measurements.
pmid: 39950887
abstract: This study covers three aspects of acoustic localisation of drones using a microphone array. First, it assesses a grid-free approach, using differential evolution, to estimate the three-dimensional position of a drone. It is found that this is indeed possible for the drone in the near-field. For larger distances, it still provides the angular position of the drone. Second, the study emphasizes the essence of localisation over small frequency bands with the bands jointly spanning a large frequency range to reveal the presence of multiple sound sources and maximise the drone localisation range. Third, it addresses the localisation ranges for six different drones.
rights: © 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
has PII: 3336065
doi: 10.1121/10.0035915
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Altena A
      type: Person
      first name: Anique
      last name: Altena
      member of: Faculty of Aerospace Engineering, Delft University of Technology, Delft, 2629HS, The Netherlands.
  slot:
    index: 2
    item: Snellen M
      type: Person
      first name: Mirjam
      last name: Snellen
      member of: Faculty of Aerospace Engineering, Delft University of Technology, Delft, 2629HS, The Netherlands.
  slot:
    index: 3
    item: Luesutthiviboon S
      type: Person
      first name: Salil
      last name: Luesutthiviboon
      member of: Faculty of Aerospace Engineering, Delft University of Technology, Delft, 2629HS, The Netherlands.
  slot:
    index: 4
    item: de Croon G
      type: Person
      first name: Guido
      last name: de Croon
      member of: Faculty of Aerospace Engineering, Delft University of Technology, Delft, 2629HS, The Netherlands.
  slot:
    index: 5
    item: Voskuijl M
      type: Person
      first name: Mark
      last name: Voskuijl
      member of: Faculty of Military Sciences, Netherlands Defence Academy, Den Helder, 1781AC, The NetherlandsA.Altena@tudelft.nl, M.Snellen@tudelft.nl, S.Luesutthiviboon@tudelft.nl, G.C.H.E.deCroon@tudelft.nl, M.Voskuijl@mindef.nl.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-01
dp: 2025 Feb 01
created: 2025-2-14T09:43
e ISSN: 2691-1191
has issn l: 2691-1191
issue: 2
has NLM journal title abbreviation: JASA Express Lett
publication name: JASA express letters
language: eng
has national library of medicine journal id: 101775177
derived from: NLM
has place of publication: United States
source: JASA Express Lett. 2025-02-01;5(2):.
volume: 5

'Cats will not be banned in Scotland'.
pmid: 39950900
doi: 10.1002/vetr.5240
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 142
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):142.
volume: 196

bTB control 'too politicised', say farmers.
pmid: 39950894
doi: 10.1002/vetr.5232
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Loeb J
      type: Person
      first name: Josh
      last name: Loeb
created: 2025-2-14T12:30
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 135
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):135.
volume: 196

Survey about role and impact of suitably qualified persons.
pmid: 39950890
doi: 10.1002/vetr.5256
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Dawson S
      type: Person
      first name: Stephen
      last name: Dawson
      member of: AMTRA, 1c Windmill Avenue, Woolpit, Bury St Edmunds, Suffolk, IP30 9UP.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:43
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
starting page: 156
ending page: 157
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):156-157.
volume: 196

Impact of gene editing on animal welfare.
pmid: 39950896
doi: 10.1002/vetr.5255
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Wolfensohn S
      type: Person
      first name: Sarah
      last name: Wolfensohn
      member of: University of Surrey, Daphne Jackson Road, Guildford, GU2 7AL.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 156
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):156.
volume: 196

Treatment failure leading to fatal cases of fasciolosis in Scottish sheep.
pmid: 39950897
doi: 10.1002/vetr.5248
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
starting page: 145
ending page: 147
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):145-147.
volume: 196

Behaviour scholarship for Animals Asia.
pmid: 39950905
doi: 10.1002/vetr.5265
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: iii
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):iii.
volume: 196

Strategy needed to tackle illegal raw meat imports.
pmid: 39950907
doi: 10.1002/vetr.5236
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 137
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):137.
volume: 196

Time for a more sustainable and hopeful vision of bovine TB freedom for the UK.
pmid: 39950899
doi: 10.1002/vetr.5260
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Glossop C
      type: Person
      first name: Christianne
      last name: Glossop
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 158
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):158.
volume: 196

Equine forum offers free live stream.
pmid: 39950906
doi: 10.1002/vetr.5268
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: iv
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):iv.
volume: 196

NI steering group kicks off bovine TB reset.
pmid: 39950904
doi: 10.1002/vetr.5233
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Loeb J
      type: Person
      first name: Josh
      last name: Loeb
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 136
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):136.
volume: 196

A hybrid magnetic reset design for the high voltage pulse generator based on forward circuit and magnetic superposition.
pmid: 39950912
abstract: Pulsed power technology has found widespread application in environmental governance, biomedicine, food processing, and other fields. This study proposes a pulse generator using forward topology and magnetic superposition to get high-voltage outputs. This design could adjust the pulse width in a relatively larger range by optimizing the coil structure and turns. The isolated power supply and trigger signal are not needed. The RCD (Resistor-Capacitor-Diode) and the third winding are used to reset the remanence. The third winding magnetic reset will take over the resetting process when the capacitor voltage of RCD is over twice the charging voltage if the magnetic flux to be reset is relatively large. By the combination of these two magnetic reset methods, the ringing of the output could be absorbed, the voltage stress on the switch could be limited to about twice the charging voltage, and the efficiency of the system could be improved. The working principle is analyzed and verified by simulation and experiments. Finally, a 20-stage pulse generator is developed, which could generate the pulse with an amplitude of 10 kV and a pulse width of 2-5 µs. With this design, the voltage and current could be easily improved by adding stages and switches in parallel.
rights: © 2025 Author(s). Published under an exclusive license by AIP Publishing.
has PII: 3335915
doi: 10.1063/5.0243028
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Guo J
      type: Person
      first name: Jinlong
      last name: Guo
      member of: The School of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
  slot:
    index: 2
    item: Zhao Y
      type: Person
      first name: Yajun
      last name: Zhao
      member of: The School of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.Taizhou Key Laboratory of Minimally Invasive Interver Campus of Zhejiang Cancer Hospital (Taizhou Cancer Hospital), Taizhou 317502, China.
  slot:
    index: 3
    item: Qi L
      type: Person
      first name: Luhao
      last name: Qi
      member of: The School of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
  slot:
    index: 4
    item: Li S
      type: Person
      first name: Shiji
      last name: Li
      member of: The School of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
  slot:
    index: 5
    item: Jin S
      type: Person
      first name: Shanshan
      last name: Jin
      member of: The School of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
  slot:
    index: 6
    item: Xu D
      type: Person
      first name: Dong
      last name: Xu
      member of: Taizhou Key Laboratory of Minimally Invasive Interver Campus of Zhejiang Cancer Hospital (Taizhou Cancer Hospital), Taizhou 317502, China.
  slot:
    index: 7
    item: Fang Z
      type: Person
      first name: Zhi
      last name: Fang
      member of: The School of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-01
dp: 2025 Feb 01
created: 2025-2-14T09:44
e ISSN: 1089-7623
has issn l: 0034-6748
issue: 2
has NLM journal title abbreviation: Rev Sci Instrum
publication name: The Review of scientific instruments
language: eng
has national library of medicine journal id: 0405571
derived from: NLM
has place of publication: United States
source: Rev Sci Instrum. 2025-02-01;96(2):.
volume: 96

Potential arrival of vet professional associates.
pmid: 39950915
doi: 10.1002/vetr.5251
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Guard P
      type: Person
      first name: Philip
      last name: Guard
      member of: Berkshire.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:44
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 153
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):153.
volume: 196

Update on livestock-associated ticks in England and Wales.
pmid: 39950922
doi: 10.1002/vetr.5254
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Biddlecombe SM
      type: Person
      first name: Sarah M
      last name: Biddlecombe
      member of: Medical Entomology and Zoonoses Ecology Group, UKHSA Porton Down, Wiltshire, SP4 0JG.
  slot:
    index: 2
    item: Brown FV
      type: Person
      first name: Faye V
      last name: Brown
      member of: Medical Entomology and Zoonoses Ecology Group, UKHSA Porton Down, Wiltshire, SP4 0JG.
  slot:
    index: 3
    item: Medlock JM
      type: Person
      first name: Jolyon M
      last name: Medlock
      member of: Medical Entomology and Zoonoses Ecology Group, UKHSA Porton Down, Wiltshire, SP4 0JG.
  slot:
    index: 4
    item: Hansford KM
      type: Person
      first name: Kayleigh M
      last name: Hansford
      member of: Medical Entomology and Zoonoses Ecology Group, UKHSA Porton Down, Wiltshire, SP4 0JG.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:45
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
starting page: 155
ending page: 156
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):155-156.
volume: 196

Appointments.
pmid: 39950927
doi: 10.1002/vetr.5269
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:45
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: iv
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):iv.
volume: 196

Development of a 1.2 MV high voltage DC power supply with SF6 insulation for an electrostatic tandem proton accelerator in accelerator-based boron neutron capture therapy system.
pmid: 39950914
abstract: This paper presents the development of a 1.2 MV high-voltage direct current (DC) power supply with an SF6 insulation for an electrostatic tandem proton accelerator utilized in an accelerator-based boron neutron capture therapy (BNCT) system. BNCT offers a promising alternative to traditional radiation therapy for the treatment of malignant brain tumors, head and neck cancers, and melanomas. The electrostatic tandem proton accelerator system, designed to produce H- ions and subsequently accelerate them to generate protons, represents a significant advancement in medical technology. Key milestones in the process include generating and maintaining a high-voltage DC power supply of 1.2 MV/45 mA for over 30 min, with rigorously testing conducted up to 750 kV/45 mA in ambient conditions. The system features an upgraded Cockcroft-Walton rectifier stage and incorporates a realistic load resistance, with final testing conducted in a tank filled with SF6 gas. Performance tests conducted in atmospheric and SF6 gas environments demonstrate the stable operation of the power supply up to 1.2 MV/45 mA, despite challenges such as corona discharge and electrical arcing in atmospheric environments. It demonstrates excellent long-term voltage and current stability, proving its suitability for tandem proton accelerators by reliably supplying 54 W of power to the dummy load. The developed system can enhance the effectiveness of BNCT systems by generating high-current proton beams, leading to improved treatment outcomes.
rights: © 2025 Author(s). Published under an exclusive license by AIP Publishing.
has PII: 3335917
doi: 10.1063/5.0220828
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Park C
      type: Person
      first name: Chawon
      last name: Park
      member of: Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, South Korea.
  slot:
    index: 2
    item: Kim M
      type: Person
      first name: Minho
      last name: Kim
      member of: Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, South Korea.
  slot:
    index: 3
    item: Jung H
      type: Person
      first name: Hyunwoo
      last name: Jung
      member of: Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, South Korea.
  slot:
    index: 4
    item: Park S
      type: Person
      first name: Seungwoo
      last name: Park
      member of: Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, South Korea.
  slot:
    index: 5
    item: Hong BH
      type: Person
      first name: Bong Hwan
      last name: Hong
      member of: Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, South Korea.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-01
dp: 2025 Feb 01
created: 2025-2-14T09:44
e ISSN: 1089-7623
has issn l: 0034-6748
issue: 2
has NLM journal title abbreviation: Rev Sci Instrum
publication name: The Review of scientific instruments
language: eng
has national library of medicine journal id: 0405571
derived from: NLM
has place of publication: United States
source: Rev Sci Instrum. 2025-02-01;96(2):.
volume: 96

Scottish shock collar ban voted down.
pmid: 39950919
doi: 10.1002/vetr.5235
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Loeb J
      type: Person
      first name: Josh
      last name: Loeb
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:45
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: 137
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):137.
volume: 196

A noise reduction method for rolling bearing based on improved Wiener filtering.
pmid: 39950913
abstract: To accurately identify compound faults of bearings, a new noise reduction method is presented. With the new method, input signals and the order of Wiener filtering are adaptively determined according to feature mode decomposition (FMD), signal evaluation index, and Euclidean distance. First, to effectively separate frequency components from vibration signals, vibration signals are decomposed into modal components based on the FMD algorithm; second, kurtosis, root mean square, and variance, which are sensitive to fault information, are selected to build evaluation vectors. Third, the Euclidean distance between the evaluation vectors of the component signal and the original signal are calculated to represent the correlation among signals. By acquiring the two component signals that have the greatest and least correlation to original signals, an actual signal and a mixed signal required by Wiener filtering can be adaptively determined. Furthermore, the order of Wiener filtering is adaptively determined with maximum kurtosis as the criterion. Finally, fault features are extracted through the spectral analysis of signals after Wiener filtering and the type of compound faults is judged based on that. To demonstrate the accuracy and effectiveness of the proposed method, the proposed method is compared with the classical method. The result of comparison shows that the presented method can restrict the noise more effectively and determine the type of complex faults of bearings more accurately.
rights: © 2025 Author(s). Published under an exclusive license by AIP Publishing.
has PII: 3335916
doi: 10.1063/5.0217945
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yu M
      type: Person
      first name: Mingyue
      last name: Yu
  slot:
    index: 2
    item: Su J
      type: Person
      first name: Jingwen
      last name: Su
  slot:
    index: 3
    item: Wang Y
      type: Person
      first name: Yunbo
      last name: Wang
  slot:
    index: 4
    item: Han C
      type: Person
      first name: Chuang
      last name: Han
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-01
dp: 2025 Feb 01
created: 2025-2-14T09:44
e ISSN: 1089-7623
has issn l: 0034-6748
issue: 2
has NLM journal title abbreviation: Rev Sci Instrum
publication name: The Review of scientific instruments
language: eng
has national library of medicine journal id: 0405571
derived from: NLM
has place of publication: United States
source: Rev Sci Instrum. 2025-02-01;96(2):.
volume: 96

Equine disease management webinars.
pmid: 39950926
doi: 10.1002/vetr.5266
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-15
dp: 2025 Feb 15
created: 2025-2-14T09:45
e ISSN: 2042-7670
has issn l: 0042-4900
issue: 4
has NLM journal title abbreviation: Vet Rec
publication name: The Veterinary record
language: eng
has national library of medicine journal id: 0031164
derived from: NLM
pg: iii
has place of publication: England
source: Vet Rec. 2025-02-15;196(4):iii.
volume: 196

Determination of phenolic constituents with LC-MS/MS and cytotoxicity evaluation of 'tar' from Pinus nigra Arnold (Pinaceae).
pmid: 39950930
abstract: In folk medicine, 'tar' is an essential drug in every situation and is obtained from Pinus nigra Arnold (Pinaceae), which is very common in Anatolia, especially in the Mediterranean Basin. This study aims to evaluate the chemical composition and determine cytotoxicity effects on the HeLa cell line and L929 cell line of the tar. The analysis of tar by LC-MS/MS revealed ten phenolic compounds: oxalic acid, salicylic acid, vanillic acid, ferulic acid, caffeic acid, 4-hydroxybenzoic acid, cinnamic acid, p-coumaric acid, and 3-hydroxycinnamic acid. Besides, total phenolic content (62.31 ± 0.31 mg GAE/g) and flavonoid content (3.43 ± 0.0006 mg QE/g) were determined. Cell viability was determined by MTT analysis. Tar has a significant cytotoxicity effect on the HeLa cell line in concentrations 100, 50, 25, 12.5, and 6.25 µg/mL. IC50 value of tar on HeLa cell was 132.9 µg/mL.
doi: 10.1080/14786419.2025.2463118
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Özgen A
      type: Person
      first name: Arzu
      last name: Özgen
      member of: Department of Medical Services and Techniques, Istanbul Gelisim University, Istanbul, Turkey.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T09:53
e ISSN: 1478-6427
has issn l: 1478-6419
has NLM journal title abbreviation: Nat Prod Res
publication name: Natural product research
language: eng
has national library of medicine journal id: 101167924
derived from: NLM
starting page: 1
ending page: 10
has place of publication: England
source: Nat Prod Res. 2025-02-14;():1-10.

Proposed Probabilistic Optimization of Radioactive Waste Disposal Facility Design Considering Long-term Uncertainty.
pmid: 39950946
abstract: In the optimization of radioactive waste disposal facility design, it is important to compare multiple facility design options with the aim of reducing the effective dose as low as reasonably achievable. In this study, a methodology for optimizing the facility design using a probabilistic approach was proposed, and two case studies were provided the application of the methodology and interpretation of the dose distributions. This methodology incorporates the time integration of the 95th percentile value and the sum of coefficients of variation extracted from the probability distribution of dose profile over time as the indicators for relative comparison on the optimization. This methodology enables consideration of the dose with uncertainty for the entire long-term assessment period in the optimization. This allows a more multifaceted comparison of options and is expected to improve the ability to explain optimization with the consideration of long-term uncertainty. While various factors including economic, social, and possibly others are relevant to the decision process, this study focuses on the dose estimations as an indicator for optimization. In the case studies, intermediate-depth disposal in Japan, which is one of the disposal systems of low-level radioactive waste, is used as an example and the groundwater release scenario was the focus. The comparison of multiple options in low-diffusivity and low-permeability layers were assumed. These are the important factors in the migration of radioactive nuclides, while other parameters can also be considered in optimization by using the proposed methodology.
rights: Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Health Physics Society.
has PII: 00004032-990000000-00229
doi: 10.1097/HP.0000000000001960
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kuroda K
      type: Person
      first name: Kazuma
      last name: Kuroda
      member of: Central Research Institute of Electric Power Industry, 1646 Abiko, Abiko-shi, Chiba 270-1194 Japan.
  slot:
    index: 2
    item: Nakabayashi R
      type: Person
      first name: Ryo
      last name: Nakabayashi
  slot:
    index: 3
    item: Sugiyama D
      type: Person
      first name: Daisuke
      last name: Sugiyama
created: 2025-2-14T12:30
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:03
e ISSN: 1538-5159
has issn l: 0017-9078
has NLM journal title abbreviation: Health Phys
publication name: Health physics
language: eng
has national library of medicine journal id: 2985093R
derived from: NLM
has place of publication: United States
source: Health Phys. 2025-02-14;():.

Representations of youth concussion recovery in health and rehabilitation sciences: a critical conceptual review.
pmid: 39950954
abstract: In the field of youth concussion, the concept of recovery has undergone little critical scrutiny. As a result, little is known about what recovery is (what recovery looks like, what constitutes a good recovery, how youth understand their own recovery).We conducted a critical conceptual review of 15 texts from health and rehabilitation sciences that implicitly or explicitly conceptualized youth concussion recovery.We identified what we have termed a dominant recovery narrative that was re/produced across texts. We have organized this narrative along three intersecting critical analytic threads: recovery as return to normal, a timeline to recovery, a responsibility to recover. We elaborate each thread, demonstrating the ways they converged to represent concussion recovery in reductive terms (i.e., undergirded by ableism and developmentalism), making it difficult to think of recovery, and recovering youth, in any other terms. The authority of the dominant narrative was seldom questioned across texts. However, there were outliers to our synthesis, which offered rare points of resistance and demonstrated how recovery might be oriented otherwise (e.g., as living well with symptoms).This study has important implications for rehabilitation practice and research which are discussed.
doi: 10.1080/09638288.2025.2462212
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Mah K
      type: Person
      first name: Katie
      last name: Mah
      member of: School of Occupational Therapy, Faculty of Health Sciences, Western University, London, Canada.Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada.
  slot:
    index: 2
    item: Gibson BE
      type: Person
      first name: Barbara E
      last name: Gibson
      member of: Department of Physical Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
  slot:
    index: 3
    item: Teachman G
      type: Person
      first name: Gail
      last name: Teachman
      member of: School of Occupational Therapy, Faculty of Health Sciences, Western University, London, Canada.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:03
e ISSN: 1464-5165
has issn l: 0963-8288
has NLM journal title abbreviation: Disabil Rehabil
publication name: Disability and rehabilitation
language: eng
has national library of medicine journal id: 9207179
rights holder: The emphasis of youth concussion recovery remains on “cure” and on returning youth to “normal”; this limited view of recovery may influence how youth view themselves as “successful” or not in recoveryImplications for clinical practice include attending to the “recovery work” that youth and their families do to adjust to life after concussion, and making space for the fears and anxieties that might accompany such work.
derived from: NLM
starting page: 1
ending page: 13
has place of publication: England
source: Disabil Rehabil. 2025-02-14;():1-13.

[Radiological protection in pediatric interventional cardiology in Latin America and the Caribbean: collaboration and challenges in Mexico].
pmid: 39950967
doi: 10.24875/ACM.24000122
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Britton-Robles SC
      type: Person
      first name: Silvia C
      last name: Britton-Robles
      member of: Departamento de Cardiología Pediátrica, Hospital Zambrano Hellion, Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, México.
  slot:
    index: 2
    item: Ubeda-de la Cerda CA
      type: Person
      first name: Carlos A
      last name: Ubeda-de la Cerda
      member of: Departamento de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad de Tarapacá, Arica, Chile.
  slot:
    index: 3
    item: Franco-Cabrera MC
      type: Person
      first name: María C
      last name: Franco-Cabrera
      member of: Departamento de Cardiología Pediátrica, Hospital Zambrano Hellion, Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, México.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:11
e ISSN: 1665-1731
has issn l: 1665-1731
has NLM journal title abbreviation: Arch Cardiol Mex
publication name: Archivos de cardiologia de Mexico
language: spa
has national library of medicine journal id: 101126728
derived from: NLM
has place of publication: Mexico
source: Arch Cardiol Mex. 2025-02-14;():.

Machine learning-based survival prediction tool for adrenocortical carcinoma.
pmid: 39950976
abstract: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with difficult to predict clinical outcomes. The S-GRAS score combines clinical and histopathological variables (tumour stage, grade, resection status, age, and symptoms) and showed good prognostic performance for patients with ACC.To improve ACC prognostic classification by applying robust machine learning (ML) models.We developed ML models to enhance outcome prediction using the published S-GRAS dataset (n=942) as the training cohort and an independent dataset (n=152) for validation. Sixteen ML models were constructed based on individual clinical variables. The best performing models were used to develop a web-based tool for individualized risk prediction.Quadratic Discriminant Analysis, Light Gradient Boosting Machine, and AdaBoost Classifier models exhibited the highest performance, predicting 5-year overall mortality (OM), and 1-year, and 3-year disease progression (DP) with F1 scores of 0.79, 0.63, and 0.83 in the training cohort, and 0.72, 0.60, and 0.83 in the validation cohort. Sensitivity and specificity for 5-year OM were at 77% and 77% in the training cohort, and 65% and 81% in the validation cohort, respectively. A web-based tool (https://acc-survival.streamlit.app) was developed for easily applicable and individualized risk prediction of mortality and disease progression.S-GRAS parameters can efficiently predict outcome in patients with ACC, even using a robust ML model approach. Our web app instantly estimates the mortality and disease progression for patients with ACC, representing an accessible tool to drive personalised management decisions in clinical practice.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society.
has PII: 8015503
doi: 10.1210/clinem/dgaf096
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Saygili ES
      type: Person
      first name: Emre Sedar
      last name: Saygili
      member of: Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale Turkey.Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham UK.
  slot:
    index: 2
    item: Elhassan YS
      type: Person
      first name: Yasir S
      last name: Elhassan
      member of: Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham UK.Department of Endocrinology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham UK.
  slot:
    index: 3
    item: Prete A
      type: Person
      first name: Alessandro
      last name: Prete
      member of: Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham UK.Department of Endocrinology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham UK.NIHR Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham UK.
  slot:
    index: 4
    item: Lippert J
      type: Person
      first name: Juliane
      last name: Lippert
      member of: Institute of Human Genetics, University of Wuerzburg, Wuerzburg Germany.
  slot:
    index: 5
    item: Altieri B
      type: Person
      first name: Barbara
      last name: Altieri
      member of: Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg Germany.
  slot:
    index: 6
    item: Ronchi CL
      type: Person
      first name: Cristina L
      last name: Ronchi
      member of: Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham UK.Department of Endocrinology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham UK.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:13
e ISSN: 1945-7197
has issn l: 0021-972X
has NLM journal title abbreviation: J Clin Endocrinol Metab
publication name: The Journal of clinical endocrinology and metabolism
language: eng
has national library of medicine journal id: 0375362
derived from: NLM
has place of publication: United States
source: J Clin Endocrinol Metab. 2025-02-14;():.

Study on the Assessment Method of Occupational Radiation Dose to Interventional Radiology Staff Wearing Two Personal Dosimeters in China for the Period 2015-2021.
pmid: 39950959
abstract: Considering workers in interventional radiology occupationally exposed to relatively higher radiation dose, it is imperative to reasonably and reliably assess the occupational exposure of these workers. This paper presents a method to evaluate the occupational exposure to the interventional radiology workers monitored by using two personal dosimeters, based on data from 115,997 workers collected by the Chinese Registry of Radiation Workers in China during the period 2015-2021. It was observed that only 17.7% (20,572 in 115,997) of interventional radiology staff had a meaningful measurable result. The scatter plot of Hp(10)over-Hp(10)under vs. Hp(10)over was obtained to classify between the proper use group and misuse group. In addition, it was found that the effective dose calculated using the single-dosimeter approach proposed by Martin and Magee was close to those obtained using two other double-dosimeter approaches. Furthermore, the Swiss ordinance algorithm was chosen to assess the occupational exposure as a conservative estimation method. Meanwhile, it was also found that the average annual effective dose in tertiary hospitals is significantly higher than that in secondary hospitals in China (Z = -2.491, p < 0.05/3 = 0.017). Based on these observations, rigorous surveillance, quality control measures, and better workload management are still necessary to correctly evaluate the occupational exposure of interventional radiology staff. Our results are expected to provide a feasible and accurate method for the evaluation of occupational radiation dose to interventional radiology staff wearing two personal dosimeters and contribute to effective prevention and control of radiation health risks.
rights: Copyright © 2025 Health Physics Society.
has PII: 00004032-990000000-00231
doi: 10.1097/HP.0000000000001961
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Fan S
      type: Person
      first name: Shengnan
      last name: Fan
      member of: National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China; Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China.
  slot:
    index: 2
    item: Zhou W
      type: Person
      first name: Wenshan
      last name: Zhou
  slot:
    index: 3
    item: Li M
      type: Person
      first name: Mengxue
      last name: Li
  slot:
    index: 4
    item: Wang T
      type: Person
      first name: Tuo
      last name: Wang
  slot:
    index: 5
    item: Deng J
      type: Person
      first name: Jun
      last name: Deng
  slot:
    index: 6
    item: Sun Q
      type: Person
      first name: Quanfu
      last name: Sun
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:03
e ISSN: 1538-5159
has issn l: 0017-9078
has NLM journal title abbreviation: Health Phys
publication name: Health physics
language: eng
has national library of medicine journal id: 2985093R
derived from: NLM
has place of publication: United States
source: Health Phys. 2025-02-14;():.

Jansen's disease: bone abnormalities beyond chondrodysplasia.
pmid: 39950977
abstract: This study aimed to assess changes in bone microarchitecture, bone formation and bone protein expression in two pediatric patients with Jansen metaphyseal chondrodysplasia (JMC), harboring the H223R-PTHR1 mutation.Bone histomorphometry, immunohistochemistry and histologic analyses were conducted on iliac crest biopsy samples from two male siblings affected by JMC (ages 6 and 8 years) and 9 healthy control males of similar age, with normal kidney function.Both JMC patients displayed irregular bone architecture, increased osteoid, and a prolonged osteoid maturation process. While trabecular volume remained normal, immunohistochemical analysis demonstrated increased in PTH1R expression in both osteoblasts and fibroblastic cells on the bone surface. Cortical bone displayed areas of intense osteoclast activity and scattered marrow fibrosis. Remarkably, osteocytes in JMC patient samples had osteoid buildup within their lacunae and canaliculi that were both shorter and less abundant. DMP1 immunohistochemistry highlighted the abnormal canalicular network in patients. FGF23 staining in osteocytes was enhanced while sclerostin was diminished.The H223R-PTH1R mutation in JMC patients leads to bone structural irregularities, hypomineralization, abnormal osteocyte morphology, and altered expression of osteocyte-derived proteins. These findings underscore the multifaceted impact of the mutant PTH1R on bone physiology and focus attention on the osteocyte as a cellular target for therapeutic intervention. Whether normalizing gene expression in osteocytes is possible and can improve bone health in JMC patients remains to be seen. Assessment of osteocyte morphology and function may provide novel diagnostic endpoints for future clinical trials with JMC therapeutics.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society.
has PII: 8015505
doi: 10.1210/clinem/dgaf097
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Pereira RC
      type: Person
      first name: Renata C
      last name: Pereira
      member of: Pediatric Nephrology, UCLA, Geffen School of Medicine, Los Angeles, CA.
  slot:
    index: 2
    item: Delany AM
      type: Person
      first name: Anne M
      last name: Delany
      member of: Center for Molecular Oncology, UConn Health, Farmington, CT.
  slot:
    index: 3
    item: Reyes M
      type: Person
      first name: Monica
      last name: Reyes
      member of: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
  slot:
    index: 4
    item: Gales B
      type: Person
      first name: Barbara
      last name: Gales
      member of: Pediatric Nephrology, UCLA, Geffen School of Medicine, Los Angeles, CA.
  slot:
    index: 5
    item: Jüppner H
      type: Person
      first name: Harald
      last name: Jüppner
      member of: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
  slot:
    index: 6
    item: Salusky IB
      type: Person
      first name: Isidro B
      last name: Salusky
      member of: Pediatric Nephrology, UCLA, Geffen School of Medicine, Los Angeles, CA.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:13
e ISSN: 1945-7197
has issn l: 0021-972X
has NLM journal title abbreviation: J Clin Endocrinol Metab
publication name: The Journal of clinical endocrinology and metabolism
language: eng
has national library of medicine journal id: 0375362
derived from: NLM
has place of publication: United States
source: J Clin Endocrinol Metab. 2025-02-14;():.

Plasma proteins predict kidney function trajectories in type 2 diabetes.
pmid: 39950984
abstract: The rate of decline in estimated glomerular filtration rate (eGFR) varies among patients with type 2 diabetes (T2D). We aimed to identify plasma proteins associated with diverse eGFR trajectories in T2D.We performed latent class mixed models analysis among patients with T2D and relatively preserved kidney function (baseline eGFR ≥60 mL/min/1.73m2) from SMART2D (n=1285) and DN (n=798) cohorts to identify patterns of eGFR trajectories. Comprehensive proteomic association with eGFR trajectories was assessed using multivariable logistic regression in the SMART2D cohort.Three distinct eGFR trajectories group: slow decline (92.2%), progressive decline (4.0%), and accelerated decline (3.8%) were identified in SMART2D and validated in DN cohort. Participants in the accelerated decline group exhibited the highest risk of progression to end-stage kidney disease (ESKD) (log-rank test, p<0.0001). Among 1448 proteins analysed in the SMART2D cohort, 19 proteins, including KIM-1 (OR=2.95, 95% CI 2.01-4.32; p=2.95x10-8), MMP7 (OR=16.5, 95% CI 5.54-49.07; p=4.61x10-7), and VSIG4 (OR=7.38, 95%CI 3.22-16.89; p=2.24x10-6), were associated with accelerated decline and 1 protein (THBD) (OR=6.34, 95% CI 2.77-14.52; p=1.26x10-5) was associated with progressive decline, independent of traditional cardio-renal risk factors including baseline kidney function. Adding these proteins to clinical risk factors (age, sex, ethnicity, eGFR, uACR, HbA1c, diabetes duration, systolic blood pressure, triglyceride) improved AUC to 0.77 (delta 0.04,p=0.057) for progressive decline and 0.93 (delta 0.09,p<0.001) for accelerated decline.Different plasma proteins are associated with progressive and accelerated eGFR decline, independent of traditional cardio-renal risk factors, some of which enhance eGFR trajectory prediction in patients with T2D.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.
has PII: 8015502
doi: 10.1210/clinem/dgaf095
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Gurung RL
      type: Person
      first name: Resham L
      last name: Gurung
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.Cardiovascular and Metabolic Disorders Signature Research Program, Duke-NUS Medical School, Singapore.
  slot:
    index: 2
    item: Zheng H
      type: Person
      first name: Huili
      last name: Zheng
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.
  slot:
    index: 3
    item: Tan JLI
      type: Person
      first name: Jia Le Ivan
      last name: Tan
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.
  slot:
    index: 4
    item: Liu S
      type: Person
      first name: Sylvia
      last name: Liu
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.
  slot:
    index: 5
    item: Ang K
      type: Person
      first name: Keven
      last name: Ang
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.
  slot:
    index: 6
    item: Liu JJ
      type: Person
      first name: Jian-Jun
      last name: Liu
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.
  slot:
    index: 7
    item: Coffman TM
      type: Person
      first name: Thomas M
      last name: Coffman
      member of: Cardiovascular and Metabolic Disorders Signature Research Program, Duke-NUS Medical School, Singapore.
  slot:
    index: 8
    item: Lim SC
      type: Person
      first name: Su Chi
      last name: Lim
      member of: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828.Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549.Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:13
e ISSN: 1945-7197
has issn l: 0021-972X
has NLM journal title abbreviation: J Clin Endocrinol Metab
publication name: The Journal of clinical endocrinology and metabolism
language: eng
has national library of medicine journal id: 0375362
derived from: NLM
has place of publication: United States
source: J Clin Endocrinol Metab. 2025-02-14;():.

CO2 Photoreduction Improvement by Carbon Nitride Utilizing the Synergism of Na Ion and Cyano Defects.
pmid: 39950986
abstract: Conversion of CO2 to high value products was considered as a focused issue towards carbon neutrality. Photocatalysis held the potential to realize the target, and graphitic carbon nitride (g-C3N4) was a competitive candidate. The photocatalytic efficiency of g-C3N4 limited by the weak adsorption of CO2 and easy recombination of charge carriers. Herein, Na ion and cyano defects was induced into g-C3N4 simultaneously using NaHSO3 as alkali molten salt to work out these obstacles. The optimized photocatalyst 3 Na-CN (the weight of NaHSO3 was 1.5 g) exhibited the highest CO yield (21.5 μmol g-1 h-1), which was 5 times than that of pristine g-C3N4 (4.29 μmol g-1 h-1). By means of experiments and characterization, 3 Na-CN displayed better performance in both light utilization and charge separation, which was reflected by the improved photocurrent response, decreased electrochemical impedance, markedly diminished fluorescence intensity, and shortened fluorescence lifetime. This result could be ascribed to the facilitation of electron-hole separation induced by cyano defects, as well as the enhancement in CO2 adsorption and activation mediated by the Na ion. This work offers a new perspective on dual modulation of graphitic carbon nitride and paves the way for the design of CO2 reduction photocatalyst.
rights: © 2025 The Authors. ChemistryOpen published by Wiley-VCH GmbH.
doi: 10.1002/open.202400431
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Li W
      type: Person
      first name: Weize
      last name: Li
      member of: Technical Center of China Tobacco Guangxi Industrial Co. Ltd, Nanning, 530001, China.
  slot:
    index: 2
    item: Hu Z
      type: Person
      first name: Zhizhong
      last name: Hu
      member of: Technical Center of China Tobacco Guangxi Industrial Co. Ltd, Nanning, 530001, China.
  slot:
    index: 3
    item: Song L
      type: Person
      first name: Lingyong
      last name: Song
      member of: Technical Center of China Tobacco Guangxi Industrial Co. Ltd, Nanning, 530001, China.
  slot:
    index: 4
    item: Lv Y
      type: Person
      first name: Yangbo
      last name: Lv
      member of: Technical Center of China Tobacco Guangxi Industrial Co. Ltd, Nanning, 530001, China.
  slot:
    index: 5
    item: Liu J
      type: Person
      first name: Jincang
      last name: Liu
      member of: Technical Center of China Tobacco Guangxi Industrial Co. Ltd, Nanning, 530001, China.
  slot:
    index: 6
    item: Lu C
      type: Person
      first name: Changtong
      last name: Lu
      member of: Technical Center of China Tobacco Henan Industrial Co. Ltd., Zhengzhou, 450016, China.
  slot:
    index: 7
    item: Xu C
      type: Person
      first name: Chunping
      last name: Xu
      member of: College of Tobacco Science and Engineering, Zhengzhou University of Light Industry, Zhengzhou, 450002, China.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:13
e ISSN: 2191-1363
has issn l: 2191-1363
has NLM journal title abbreviation: ChemistryOpen
publication name: ChemistryOpen
language: eng
has national library of medicine journal id: 101594811
derived from: NLM
pg: e202400431
has place of publication: Germany
source: ChemistryOpen. 2025-02-14;():e202400431.

Amino Acids-Enabled Fast-Restore of Triplet-Triplet Annihilation Upconversion Luminescence for Background-Free Sensing of Herbicides.
pmid: 39951009
abstract: Overuse of herbicides poses a serious threat to ecosystems and human health; thus, the accurate determination of herbicide residue is very meaningful. Thanks to the advantage of no background fluorescence interference, the upconversion luminescence allows for reliable analysis of target molecules in complicated samples. Here, through screening of 20 natural amino acids, it is discovered that the photooxidation of methionine exhibited the fastest recovery rate of triplet-triplet annihilation upconversion (TTA-UC) luminescence via oxygen consumption, which is 400-fold faster compared to the well-known photooxidation of oleic acid. Furthermore, oxygen-resistant, small-size, red-to-blue TTA-UC nanoparticles with a record upconversion efficiency (7.2%, normalized to 100%) are prepared using hydrophobic butyl methionine as an oxygen scavenger. Surface negatively charged TTA-UC nanoparticles are able to selectively enrich positively charged paraquat on their surface. Accordingly, a photoinduced electron transfer process occurred between the triplet excited state of the photosensitizer and the electron-deficient paraquat, quenching the upconversion luminescence. Relying on this principle, TTA-UC-based paraquat sensing is achieved with a fast response (less than 1 s), high selectivity, and a low limit of detection (1.54 µg mL-1). Further, the TTA-UC nanoparticles are utilized to implement paraquat analysis in lake water without sample pretreatment.
rights: © 2025 Wiley‐VCH GmbH.
doi: 10.1002/smtd.202401945
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Qi F
      type: Person
      first name: Fang
      last name: Qi
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
  slot:
    index: 2
    item: Feng HJ
      type: Person
      first name: Hong-Juan
      last name: Feng
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
  slot:
    index: 3
    item: Li JY
      type: Person
      first name: Jia-Yao
      last name: Li
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
  slot:
    index: 4
    item: Peng Y
      type: Person
      first name: Yi
      last name: Peng
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
  slot:
    index: 5
    item: Jiang LH
      type: Person
      first name: Lin-Han
      last name: Jiang
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
  slot:
    index: 6
    item: Li YZ
      type: Person
      first name: Ying-Ze
      last name: Li
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
  slot:
    index: 7
    item: Zeng L
      type: Person
      first name: Le
      last name: Zeng
      member of: School of Materials Science and Engineering, Nankai University, Tianjin, 300350, P. R. China.
  slot:
    index: 8
    item: Huang L
      type: Person
      first name: Ling
      last name: Huang
      member of: Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:33
e ISSN: 2366-9608
has issn l: 2366-9608
has NLM journal title abbreviation: Small Methods
publication name: Small methods
language: eng
has national library of medicine journal id: 101724536
derived from: NLM
pg: e2401945
has place of publication: Germany
source: Small Methods. 2025-02-14;():e2401945.

Occurrence of dental caries, the prevalence of hygiene and dietary habits, and the influence of the workout session on the selected parameters of saliva in youth swimmers.
pmid: 39951005
abstract: Poor oral health can affect the overall health of the body, which may result in suboptimal performance in sports.The aim of the present study was to evaluate the occurrence of tooth decay, the prevalence of hygiene and dietary habits, and the influence of the workout session on the selected salivary parameters in youth swimmers.The study involved 40 adolescents, aged 12-15 years (mean age: 13 ±0.5 years), including 30 competitive swimmers and 10 controls. The decayed, missing and filled teeth index (DMFT) was assessed. Data on oral hygiene and dietary habits was collected through a questionnaire created by the authors. Salivary samples were collected from all subjects in the morning and in the afternoon, and from swimmers before and after training. The salivary flow rate (V), pH, buffering capacity, and calcium (Ca) level were measured.The DMFT in the group of swimmers was 4.5 ±3.54, which was significantly higher than in the control group (1.6 ±2.59) (p = 0.0007). There were no statistically significant differences in oral hygiene habits between the 2 groups. However, swimmers significantly more often consumed chocolate bars (p = 0.004), energy drinks (p = 0.017) and water (p = 0.002) as compared to the control group. Among the consumed beverages, significantly more sweet carbonated drinks were consumed by swimmers than controls (p = 0.026). After the workout session, both in the morning and in the afternoon, there was a significant decrease in V (p = 0.006 and p = 0.009, respectively) and a significant increase in the Ca level (p = 0.001 and p = 0.001, respectively) in swimmers. While comparing swimmers before training with the control group in the morning, significantly higher V (p = 0.012) and lower pH (p = 0.003) were observed in swimmers. In the afternoon, significantly lower pH was found in swimmers (p = 0.006).Oral health prevention and promotion should be an important aspect of sports participation, through greater awareness of the impact of oral hygiene an[cell cut: 2065 characters, first 2000 kept]
doi: 10.17219/dmp/187213
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Grzesiak-Gasek I
      type: Person
      first name: Iwona
      last name: Grzesiak-Gasek
      member of: Medical Innovation Center, Wroclaw, Poland.
  slot:
    index: 2
    item: Dębska-Łasut K
      type: Person
      first name: Katarzyna
      last name: Dębska-Łasut
      member of: Department of Periodontology, Wroclaw Medical University, Poland.
created: 2025-2-14T12:30
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:33
e ISSN: 2300-9020
has issn l: 1644-387X
has NLM journal title abbreviation: Dent Med Probl
publication name: Dental and medical problems
language: eng
has national library of medicine journal id: 101205669
derived from: NLM
has place of publication: Poland
source: Dent Med Probl. 2025-02-14;():.

Are the non-profit organizations being an effective way to empower and integrate children with special needs.
pmid: 39951031
abstract: Non-profit organizations (NpO) are essential in society, particularly in their efforts to empower and integrate those with special needs, such as children with mental disabilities (CWMD). This study seeks to investigate the rationales behind the perception of NpO as a potent instrument for empowering and integrating this specific cohort of persons. The study monitored and extrapolated published intellectual production on NpO's functional functions in delivering services and enabling PWSN using a descriptive-analytical technique. The applied aspect used the mixed approach, which combines quantitative and qualitative approaches using the explanatory sequential design strategy. The research team collected quantitative data and analyzed it first, then qualitative data and analyzed it second. The field study comprised 225 professionals in all fields and 225 PWSN parents from 45 associations and NpO in six Kingdom districts.
doi: 10.1080/17483107.2025.2463553
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Alsaif TM
      type: Person
      first name: Talal M
      last name: Alsaif
      member of: Strategy Management, MSC, Strategic Quality Management, University of Ha'il - KSA, Hail, Saudi Arabia.
  slot:
    index: 2
    item: Alamr AR
      type: Person
      first name: Abdulaziz R
      last name: Alamr
      member of: Curriculum and Instruction, Faculty of Education, University of Ha'il - KSA, Hail, Saudi Arabia.
  slot:
    index: 3
    item: Diab HM
      type: Person
      first name: Hanan M
      last name: Diab
      member of: Educational Technology, Faculty of Education, University of Ha'il - KSA, Hail, Saudi Arabia.
  slot:
    index: 4
    item: Ibrahem UM
      type: Person
      first name: Usama M
      last name: Ibrahem
      member of: Educational Technology, Faculty of Education, University of Ha'il - KSA, Hail, Saudi Arabia.Educational Technology Professor, Suez Canal University, Egypt.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T10:52
e ISSN: 1748-3115
has issn l: 1748-3107
has NLM journal title abbreviation: Disabil Rehabil Assist Technol
publication name: Disability and rehabilitation. Assistive technology
language: eng
has national library of medicine journal id: 101255937
rights holder: Rehabilitation Implications - Non-profit organizations frequently offer a variety of programs that cater to the educational, social, emotional, and physical needs of children with mental disabilities. This comprehensive strategy can result in more efficacious rehabilitation outcomes.By promoting community engagement and awareness, non-profit organizations facilitate the integration of children with mental disabilities into society. This integration is essential for diminishing stigma and fostering acceptance, so substantially improving the quality of life for these individuals.Non-profit organizations often act as intermediaries connecting families of children with mental disabilities to vital services, including treatment, counseling, and educational programs. Enhanced access to these materials can promote more effective rehabilitation procedures.Numerous non-profit groups participate in advocacy initiatives to impact public policy concerning mental health and disability rights. Their efforts may result in enhanced financing, legislation, and support structures that further rehabilitation initiatives for children with mental disabilities.
derived from: NLM
starting page: 1
ending page: 12
has place of publication: England
source: Disabil Rehabil Assist Technol. 2025-02-14;():1-12.

Modified Martin Procedure for Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS).
pmid: 39951033
abstract: To evaluate the therapeutic effect of the modified Martin procedure for patients with megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS).The authors retrospectively analyzed the medical records of patients diagnosed with MMIHS who underwent surgical treatment at their institute between August 2019 and June 2023. The modified Martin procedure and Bishop-Koop procedure were performed for the patients. Data, including demographics, operative time, intraoperative blood loss, complications and clinical outcomes, were collected.A total of 11 children with MMIHS were enrolled in this study. The mean age of the patients was 4.08 ± 1.69 y, and seven cases (63.64%) were male. The average operation time was 312.09 ± 108.88 min, with an average intraoperative blood loss of 25.82 ± 6.42 ml. The first postoperative defecation time was 3.60 ± 0.91 d. Patients took an average of 4.10 ± 0.40 d to resume eating after surgery, and their average length of hospital stay was 24.64 ± 4.52 d. Postoperative follow-up results showed that of the nine surviving children, two patients required intermittent intravenous nutrition support, and seven patients had successfully transitioned from parenteral nutrition support. In this study, two patients eventually died of multiple organ failure.The modified Martin procedure is a promising method for treating MMIHS. The patients exhibited positive nutritional status and satisfactory outcomes during the follow-up period.
rights: © 2024. The Author(s).
has PII: 10.1007/s12098-024-05404-7
doi: 10.1007/s12098-024-05404-7
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Tian L
      type: Person
      first name: Li
      last name: Tian
      member of: Department of Pediatric Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, 430030, Hubei, China.
  slot:
    index: 2
    item: Ma C
      type: Person
      first name: Chensen
      last name: Ma
      member of: Department of Pediatric Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, 430030, Hubei, China.
  slot:
    index: 3
    item: Cao P
      type: Person
      first name: Peng
      last name: Cao
      member of: Department of Pediatric Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, 430030, Hubei, China.
  slot:
    index: 4
    item: Yu D
      type: Person
      first name: Donghai
      last name: Yu
      member of: Department of Pediatric Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. yudonghaitj@126.com.Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, 430030, Hubei, China. yudonghaitj@126.com.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:02
e ISSN: 0973-7693
has issn l: 0019-5456
has NLM journal title abbreviation: Indian J Pediatr
publication name: Indian journal of pediatrics
language: eng
has national library of medicine journal id: 0417442
derived from: NLM
has place of publication: India
source: Indian J Pediatr. 2025-02-14;():.

Symptoms Associated With Gadolinium Exposure: Different Patterns and Rates Between Linear and Macrocyclic Gadolinium-Based Contrast Agents.
pmid: 39951051
abstract: Some patients who received multiple administrations of gadolinium-based contrast agents (GBCAs) have been reported to develop symptoms associated with gadolinium exposure (SAGE). The aim of this study was to analyze pharmacovigilance data and to explore the various SAGE patterns of linear and macrocyclic GBCAs among patients exhibiting 3 or more SAGE symptoms.SAGE were identified from a review of the scientific literature, and the corresponding preferred terms (PTs) were searched in each system organ class recorded in the FDA Adverse Event Reporting System (FAERS). To ensure the comparability of data, 3 macrocyclic and 3 linear extracellular GBCAs currently approved for intravenous administration in the United States were considered. Only patients with 3 or more SAGE symptoms were included. SAGE weights, representing the percentage of SAGE symptoms among all adverse events collected over a 6-year period from 2014 to 2019, were calculated for each GBCA. The frequency of these symptoms to occur in sets of 3 PT combinations was also analyzed. The 3 PT combinations were calculated by first selecting the PT with the highest occurrence for a GBCA and then combining it with all the PTs accounting for 5% or more of the total adverse events reported for the respective GBCA. This led to identify the most prevalent 3 PT combinations per GBCA. Moreover, in order to determine whether or not SAGE symptoms were specific to GBCAs, data for 4 water-soluble iodinated contrast media were also extracted from the FAERS database over the same period, using the SAGE list of symptoms as reference.The analysis of FAERS data revealed a significantly higher SAGE weight for the linear GBCAs (20%-24%) than for the macrocyclic GBCAs (5%-9%). For the linear agents, the most prevalent 3 PT combinations of SAGE symptoms were reported in 152-164 occurrences, whereas for the macrocyclic agents, this range was significantly lower (1-13 occurrences). Moreover, all these agents could be categorized in 3[cell cut: 2891 characters, first 2000 kept]
rights: Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.
has PII: 00004424-990000000-00293
doi: 10.1097/RLI.0000000000001160
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Shahid I
      type: Person
      first name: Imran
      last name: Shahid
      member of: From the Vigilance and Medical Information Department, Guerbet, Roissy CDG Cedex, France.
  slot:
    index: 2
    item: Lancelot E
      type: Person
      first name: Eric
      last name: Lancelot
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-17
dp: 2025 Feb 17
created: 2025-2-14T11:12
e ISSN: 1536-0210
has issn l: 0020-9996
has NLM journal title abbreviation: Invest Radiol
publication name: Investigative radiology
language: eng
has national library of medicine journal id: 0045377
derived from: NLM
has place of publication: United States
source: Invest Radiol. 2025-02-17;():.

Probiotics: A New Approach for the Prevention and Treatment of Cervical Cancer.
pmid: 39951049
abstract: Cervical cancer is closely linked to high-risk human papillomavirus (HR-HPV) infections which could crosstalk with the diversity of microorganisms within the cervicovaginal microbiota (CVM). Conventional treatments can disrupt the host microbial communities, which in turn affect the efficacy and side effects of these interventions, potentially jeopardizing the lives and health of patients. Therefore, there is a need to develop new approaches for the prevention and treatment of cervical cancer, and probiotics have shown significant potential as effective agents against cervical cancer. Studies have demonstrated that probiotics induce anticancer action by inducing apoptosis in tumor cells, inhibiting metastasis, reducing inflammation, enhancing immune functions, and modifying the effect of chemo/radiation therapy. Recent reports showed that probiotics had the ability to restore the CVM, clear HPV infections in cervical epithelial cells, and modulate immune responses. Despite these promising findings, the efficacy and safety of probiotic formulations require further validation through comprehensive research. This review focused on elucidating the mechanism behind the anticancer action and the importance of addressing the challenges associated with the clinical application of probiotics to realize their full potential as a novel and complementary approach in the prevention and treatment of cervical cancer.
rights: © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12602-025-10479-5
doi: 10.1007/s12602-025-10479-5
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Li H
      type: Person
      first name: Hui
      last name: Li
      member of: Department of Gynaecology and Obstetrics, School of Maternity and Children's Clinical Medicine, China Three Gorges University, Yichang, 443002, China.Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.The Institute of Infection and Inflammation, China Three Gorges University, Yichang, 443002, China.Department of Gynaecology and Obstetrics, Ren-He Hospital, Affiliated of China Three Gorges University, Yichang, 443001, China.
  slot:
    index: 2
    item: Xu Z
      type: Person
      first name: Zhen
      last name: Xu
      member of: Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.The Institute of Infection and Inflammation, China Three Gorges University, Yichang, 443002, China.Department of Gynaecology and Obstetrics, Ren-He Hospital, Affiliated of China Three Gorges University, Yichang, 443001, China.
  slot:
    index: 3
    item: Liu C
      type: Person
      first name: Chaoqi
      last name: Liu
      member of: Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
  slot:
    index: 4
    item: Deng J
      type: Person
      first name: Jinfang
      last name: Deng
      member of: Department of Gynaecology and Obstetrics, Ren-He Hospital, Affiliated of China Three Gorges University, Yichang, 443001, China.
  slot:
    index: 5
    item: Li Z
      type: Person
      first name: Ziqin
      last name: Li
      member of: Department of Gynaecology and Obstetrics, Ren-He Hospital, Affiliated of China Three Gorges University, Yichang, 443001, China.
  slot:
    index: 6
    item: Zhou Y
      type: Person
      first name: Yongqin
      last name: Zhou
      member of: Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China. zyjzyq@163.com.The Institute of Infection and Inflammation, China Three Gorges University, Yichang, 443002, China. zyjzyq@163.com.
  slot:
    index: 7
    item: Li Z
      type: Person
      first name: Zhiying
      last name: Li
      member of: Department of Gynaecology and Obstetrics, Ren-He Hospital, Affiliated of China Three Gorges University, Yichang, 443001, China. 3642365175@qq.com.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:04
e ISSN: 1867-1314
has issn l: 1867-1306
has NLM journal title abbreviation: Probiotics Antimicrob Proteins
publication name: Probiotics and antimicrobial proteins
language: eng
has national library of medicine journal id: 101484100
derived from: NLM
has place of publication: United States
source: Probiotics Antimicrob Proteins. 2025-02-14;():.

Development of a Workplace Training for Veterinary Hospital Technicians and Assistants Following the ADDIE Model.
pmid: 39951060
abstract: Workplace training gaps for new technicians and staff throughout the veterinary medical education community leave many feeling unsupported and result in challenges with retention, satisfaction, and confidence. Three registered veterinary lead technicians [VLT] teamed up with an instructional developer to design, develop, and implement a blended learning training to meet these needs. Strategies involved a blend of instructional tools, including a learning management system (Moodle) and corresponding workbooks all tied together through use of the instructional design model, ADDIE. The ADDIE Model is an instructional design process widely utilized in multiple fields to develop effective learning content: A = Analyze, D = Design, D = Develop, I = Implement, E = Evaluation. Preliminary data indicate positive outcomes for both trainees and VLTs while we wait on long-term retention tracking.
doi: 10.3138/jvme-2024-0098
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Shin T
      type: Person
      first name: Tiffany
      last name: Shin
      member of: North Carolina State University College of Veterinary Medicine. Raleigh, NC 27609.
  slot:
    index: 2
    item: Derks K
      type: Person
      first name: Kobi
      last name: Derks
      member of: Durham NC 27278. United States.
  slot:
    index: 3
    item: LaJuett S
      type: Person
      first name: Stefanie
      last name: LaJuett
      member of: Medaille University in Buffalo, NY. Wendell, NC, 27591.
  slot:
    index: 4
    item: McClour A
      type: Person
      first name: Anna
      last name: McClour
      member of: Murray State College in Tishomingo, OK. Clayton, NC, 27520.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-13
dp: 2025 Feb 13
created: 2025-2-14T11:13
ISSN: 0748-321X
has issn l: 0748-321X
has NLM journal title abbreviation: J Vet Med Educ
publication name: Journal of veterinary medical education
language: eng
has national library of medicine journal id: 7610519
derived from: NLM
pg: e20240098
has place of publication: Canada
source: J Vet Med Educ. 2025-02-13;():e20240098.

Shelter Medicine Programs Support Multiple AAVMC Competency Domains: A Survey of Shelter Medicine Programming at AVMA-Accredited Colleges.
pmid: 39951099
abstract: Shelter medicine is a veterinary specialty that intersects with primary care, community practice, and animal welfare. The purpose of this study was to evaluate the availability of formal (for-credit) education in shelter medicine at American Veterinary Medical Association-accredited colleges of veterinary medicine (CVMs). A 24-question survey, available from July to September 2023, was distributed to targeted faculty members at each CVM. A total of 43 of 54 colleges responded (80%). Formal education in shelter medicine was offered by 38 (88%) institutions. The median shelter medicine program starting year was 2012 (interquartile range [IQR] 2007-2017) and program duration was a median of 12 years (IQR 6-16). The median number of Association of American Veterinary Medical Colleges competency domains addressed through shelter medicine program instruction in colleges with formal shelter medicine education was 7/9 (IQR 4-8); the mode was 9/9. Responding institutions employed 118 shelter medicine faculty and instructors with a median of two shelter medicine faculty members (IQR 2-4) employed per college. In total, 30 instructors were adjuncts (25%), and only 6 of 118 (5%) were tenured. Nine of the 43 CVMs (21%) indicated that the shelter medicine program had been discontinued at some point. Lack of faculty (5/9; 56%) was the most commonly stated reason, followed by lack of a relationship with a shelter (4/9; 44%). Program instability may also be related to factors unique to shelter medicine programs, including increased faculty effort required to secure and maintain funding and community partnerships, competing demands of funders and program stakeholders, and a low proportion of tenured, boarded and permanent faculty.
doi: 10.3138/jvme-2024-0105
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Dalrymple AM
      type: Person
      first name: Aimee M
      last name: Dalrymple
      member of: Shelter Veterinary Care Consulting LLC, 841 Worcester St, Ste E-114, Natick, MA USA.
  slot:
    index: 2
    item: DeTar LG
      type: Person
      first name: Lena G
      last name: DeTar
      member of: Maddie's Shelter Medicine Program, Cornell University College of Veterinary Medicine, 930 Campus Road, Ithaca, NY 14853.
  slot:
    index: 3
    item: Weisent J
      type: Person
      first name: Jennifer
      last name: Weisent
      member of: University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996.
  slot:
    index: 4
    item: Kreisler RE
      type: Person
      first name: Rachael E
      last name: Kreisler
      member of: 19555 North 59th Avenue Midwestern University College of Veterinary Medicine, Glendale, AZ USA.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:13
ISSN: 0748-321X
has issn l: 0748-321X
has NLM journal title abbreviation: J Vet Med Educ
publication name: Journal of veterinary medical education
language: eng
has national library of medicine journal id: 7610519
derived from: NLM
pg: e20240105
has place of publication: Canada
source: J Vet Med Educ. 2025-02-14;():e20240105.

[Large ship or dinghy-it does not matter; neurourology is part of the urological fleet].
pmid: 39951102
has PII: 10.1007/s00120-024-02513-1
doi: 10.1007/s00120-024-02513-1
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Gross AJ
      type: Person
      first name: Andreas J
      last name: Gross
      member of: Abteilung für Urologie, Asklepios Klinik Barmbek, Rübenkamp 220, 22307, Hamburg, Deutschland. an.gross@asklepios.com.
  slot:
    index: 2
    item: Pannek J
      type: Person
      first name: Jürgen
      last name: Pannek
      member of: Schweizer Paraplegiker-Zentrum, Guido A. Zäch Strasse 1, 6207, Nottwil, Schweiz. juergen.pannek@paraplegie.ch.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
starting page: 105
ending page: 107
has place of publication: Germany
source: Urologie. 2025-02;64(2):105-107.
volume: 64

http://rdf.ncbi.nlm.nih.gov/pubmed/39951103
pmid: 39951103
has PII: 10.1007/s00120-025-02521-9
doi: 10.1007/s00120-025-02521-9
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
starting page: 192
ending page: 198
has place of publication: Germany
source: Urologie. 2025-02;64(2):192-198.
volume: 64

http://rdf.ncbi.nlm.nih.gov/pubmed/39951105
pmid: 39951105
has PII: 10.1007/s00120-025-02525-5
doi: 10.1007/s00120-025-02525-5
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
starting page: 200
ending page: 209
has place of publication: Germany
source: Urologie. 2025-02;64(2):200-209.
volume: 64

http://rdf.ncbi.nlm.nih.gov/pubmed/39951106
pmid: 39951106
has PII: 10.1007/s00120-025-02527-3
doi: 10.1007/s00120-025-02527-3
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
starting page: 210
ending page: 211
has place of publication: Germany
source: Urologie. 2025-02;64(2):210-211.
volume: 64

http://rdf.ncbi.nlm.nih.gov/pubmed/39951104
pmid: 39951104
has PII: 10.1007/s00120-025-02524-6
doi: 10.1007/s00120-025-02524-6
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
pg: 199
has place of publication: Germany
source: Urologie. 2025-02;64(2):199.
volume: 64

http://rdf.ncbi.nlm.nih.gov/pubmed/39951107
pmid: 39951107
has PII: 10.1007/s00120-025-02518-4
doi: 10.1007/s00120-025-02518-4
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
starting page: 212
ending page: 213
has place of publication: Germany
source: Urologie. 2025-02;64(2):212-213.
volume: 64

http://rdf.ncbi.nlm.nih.gov/pubmed/39951108
pmid: 39951108
has PII: 10.1007/s00120-025-02519-3
doi: 10.1007/s00120-025-02519-3
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02
dp: 2025 Feb
created: 2025-2-14T11:13
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 2
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
derived from: NLM
starting page: 214
ending page: 216
has place of publication: Germany
source: Urologie. 2025-02;64(2):214-216.
volume: 64

Global Prevalence of Overactive Bladder: A Systematic Review and Meta-analysis.
pmid: 39951109
abstract: This study aims to systematically estimate the global prevalence of overactive bladder (OAB), identify demographic and regional factors contributing to prevalence variations, and assess trends in prevalence over the past two decades.This cross-sectional study was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline. From inception to April 2024, computerized searches for OAB prevalence-related literature were conducted on PubMed, Embase, Web of Science, and Cochrane. Studies of OAB prevalence in the general population were included. Two independent researchers conducted the screening, data extraction, and quality assessment of the included studies.A total of 53 studies, encompassing 610,438 participants, were ultimately included in the analysis. The meta-analysis determined the global prevalence of OAB to be 20% (95% CI 0.18-0.21). Over the past 20 years, there has been an increase in OAB prevalence, rising from 18.1% (95% CI 0.13-0.23) to 23.9% (95% CI 0.19-0.29). Among women, the prevalence of OAB was 21.9% (95% CI 0.20-0.24), indicating higher rates compared to men (OR = 16.1, 95% CI 0.15-0.18). The study also found higher prevalence rates among overweight and obese individuals (OR = 18.6, 95% CI 0.13-0.24) and those aged 60 years and above (OR = 28.3, 95% CI 0.24-0.33). Middle-income countries exhibited higher prevalence rates compared to high-income countries.The study highlights higher risks of OAB among obese individuals, women, and the elderly. OAB prevalence has shown an increasing trend over the past 20 years.
rights: © 2025. The Author(s).
has PII: 10.1007/s00192-024-06029-2
doi: 10.1007/s00192-024-06029-2
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zhang L
      type: Person
      first name: Lin
      last name: Zhang
      member of: Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, China.
  slot:
    index: 2
    item: Cai N
      type: Person
      first name: Nian
      last name: Cai
      member of: Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, China.
  slot:
    index: 3
    item: Mo L
      type: Person
      first name: Li
      last name: Mo
      member of: Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, China.
  slot:
    index: 4
    item: Tian X
      type: Person
      first name: Xiaofang
      last name: Tian
      member of: Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, China.
  slot:
    index: 5
    item: Liu H
      type: Person
      first name: Hongcen
      last name: Liu
      member of: Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, China.
  slot:
    index: 6
    item: Yu B
      type: Person
      first name: Bohai
      last name: Yu
      member of: Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen City, Guangdong Province, China. wwwcnwxx6688@163.com.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:13
e ISSN: 1433-3023
has issn l: 0937-3462
has NLM journal title abbreviation: Int Urogynecol J
publication name: International urogynecology journal
language: eng
has national library of medicine journal id: 101567041
derived from: NLM
has place of publication: England
source: Int Urogynecol J. 2025-02-14;():.

Research progress of TRPV4 in pain over the past 20 years: a bibliometric analysis.
pmid: 39951114
abstract: This study aims to explore the research hotspots and future research trends of transient receptor potential vanilloid 4 (TRPV4) in pain over the past two decades, with the objective of gaining insight into the development direction and focus of this field. A total of 791 articles were included in this study by searching the Web of Science Core Collection (WOSCC) database. To enhance research quality and accuracy, keywords with similar meanings were combined to eliminate ambiguity. Data visualization analysis was conducted using CiteSpace and VOSviewer, encompassing the examination of countries, research institutions, authors, journals, keywords, references, and categories. Over the past 20 years, 791 scientific articles on TRPV4 and pain have been reviewed, originating from 52 countries, involving 885 research units, 4121 authors, and published in 332 journals. The United States, China, and Japan emerged as core contributors in this field. Prominent research institutions include Duke University (United States) and the University of California, San Francisco (United States). The most prolific researchers include Liedtke, Wolfgang (United States), Bunnett, Nigel W. (United States), and Yue, Shou-wei (China). Research on TRPV4 and pain predominantly focuses on the molecular mechanisms, role of pain models, drug development, and clinical applications, aimed at advancing pain treatment. This study provides a comprehensive overview of the literature on TRPV4 and pain over the past two decades, offering researchers and scholars fresh insights into the field's development trends and future directions.
rights: © 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00210-025-03846-0
doi: 10.1007/s00210-025-03846-0
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Huang L
      type: Person
      first name: Lele
      last name: Huang
      member of: Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, China.Beijing Key Laboratory of Sports Injuries, Beijing, China.Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China.
  slot:
    index: 2
    item: Xuan Q
      type: Person
      first name: Qiwen
      last name: Xuan
      member of: School of Traditional Chinese Medicine, Naval Medical University, Shanghai, China.
  slot:
    index: 3
    item: Li Y
      type: Person
      first name: Ying
      last name: Li
      member of: Department of Rehabilitation Medicine, The First Affiliated Hospital of the Naval Medical University,, No. 168 Changhai Road, Yangpu District, Shanghai, China. 1179892653@qq.com.
  slot:
    index: 4
    item: Huang J
      type: Person
      first name: Jinghui
      last name: Huang
      member of: Department of Rehabilitation Medicine, The First Affiliated Hospital of the Naval Medical University,, No. 168 Changhai Road, Yangpu District, Shanghai, China. huangran_1234@163.com.
  slot:
    index: 5
    item: Fang F
      type: Person
      first name: Fanfu
      last name: Fang
      member of: Department of Rehabilitation Medicine, The First Affiliated Hospital of the Naval Medical University,, No. 168 Changhai Road, Yangpu District, Shanghai, China. fangfanfu@126.com.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:14
e ISSN: 1432-1912
has issn l: 0028-1298
has NLM journal title abbreviation: Naunyn Schmiedebergs Arch Pharmacol
publication name: Naunyn-Schmiedeberg's archives of pharmacology
language: eng
has national library of medicine journal id: 0326264
derived from: NLM
has place of publication: Germany
source: Naunyn Schmiedebergs Arch Pharmacol. 2025-02-14;():.

Febuxostat protects from Doxorubicin induced hepatotoxicity in rats via regulation of NF-κB p65/NLRP3 inflammasome and SIRT-1/AMPK pathways.
pmid: 39951115
abstract: Doxorubicin (DOX) is a highly potent broad-spectrum anticancer drug, but it has severe side effects, including hepatotoxicity. Therefore, we evaluated the efficacy of febuxostat (FBX), a specific inhibitor of xanthine oxidase and antioxidant, in blocking hepatotoxicity associated with DOX in rats. Rats were treated with FBX (10 or 15 mg/kg/day orally for 2 weeks) and given DOX (15 mg/kg as single dose at the 7th day, intraperitoneal) to induce hepatotoxicity. The results indicated that FBX could reduce the pathological alterations of liver tissues induced by DOX and ameliorate the inappropriate changes in liver function biomarkers (AST, ALT, and ALP) in serum, oxidative stress parameters (catalase, superoxide dismutase, NOX1, NQO-1, HO-1, Keap-1, and Nrf2) and inflammatory markers in the liver (NF-κB p65, TNF-α, NLRP3). Additionally, FBX attenuated the p53, BAX, cytochrome C, caspase-9, and caspase-3 levels to restrain cell apoptosis. In addition, FBX therapy was found to increase protein levels of SIRT-1 and AMPK in the liver. These findings demonstrate that FBX can reduce the hepatotoxicity caused by DOX in rats through mechanisms that counteract oxidative stress, inflammation, and apoptosis.
rights: © 2025. The Author(s).
has PII: 10.1007/s00210-025-03808-6
doi: 10.1007/s00210-025-03808-6
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: El-Dessouki AM
      type: Person
      first name: Ahmed M
      last name: El-Dessouki
      member of: Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12566, Egypt.
  slot:
    index: 2
    item: Yousef EH
      type: Person
      first name: Eman H
      last name: Yousef
      member of: Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt.
  slot:
    index: 3
    item: Raslan NA
      type: Person
      first name: Nahed A
      last name: Raslan
      member of: Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt.Clinical Pharmacy Program, College of Health Sciences and Nursing, Al-Rayan Colleges, Madina, Saudi Arabia.
  slot:
    index: 4
    item: Alwakeel AI
      type: Person
      first name: Asmaa I
      last name: Alwakeel
      member of: Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt.
  slot:
    index: 5
    item: Ibrahim S
      type: Person
      first name: Samar
      last name: Ibrahim
      member of: Pharmacy Practice and Clinical Pharmacy Department, Faculty of Pharmacy, Galala University, Ataka, Egypt.
  slot:
    index: 6
    item: Alzokaky AA
      type: Person
      first name: Amany A
      last name: Alzokaky
      member of: Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt. aalzokaky@horus.edu.eg.Pharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, 11651, Egypt. aalzokaky@horus.edu.eg.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:14
e ISSN: 1432-1912
has issn l: 0028-1298
has NLM journal title abbreviation: Naunyn Schmiedebergs Arch Pharmacol
publication name: Naunyn-Schmiedeberg's archives of pharmacology
language: eng
has national library of medicine journal id: 0326264
derived from: NLM
has place of publication: Germany
source: Naunyn Schmiedebergs Arch Pharmacol. 2025-02-14;():.

Efforts of the Pharmaceuticals and Medical Devices Agency of Japanese regulatory agency in supporting biosimilar development and disseminate information.
pmid: 39951116
abstract: Information on biosimilars was rarely disseminated on the Pharmaceuticals and Medical Devices Agency (PMDA) website of the Japanese Regulatory Agency until the fiscal year (FY) 2022. Therefore, the PMDA website for biosimilars was created in FY 2023. This study confirmed the PMDA website for biosimilars and surveyed information about the approval fiscal year, brand name, indications at the initial approval, type of biopharmaceuticals, and disease area at the initial approval based on review reports and the List of Approved Products. The PMDA website for biosimilars provides information on the definition of biosimilar, approved biosimilar products, related guidelines and notifications, learning videos, presentation material, and publication articles. As of March 2024, 35 biosimilars were approved in Japan based on the following 18 active pharmaceutical ingredients: somatropin, epoetin-alfa, filgrastim, infliximab, insulin glargine, rituximab, etanercept, trastuzumab, agalsidase beta, bevacizumab, teriparatide, darbepoetin-alfa, insulin lispro, adalimumab, insulin aspart, ranibizumab, pegfilgrastim, and ustekinumab. The disease area comprised nine patterns: rheumatology, oncology, hematology, gastroenterology, dermatology, endocrinology, ophthalmology, bone, and inborn errors represented in numbers and percentages for each pattern: 12 (23.1%), 9 (17.3%), 8 (15.4%), 7 (13.5%), 7 (13.5%), 5 (9.6%), 2 (3.8%), 1 (1.9%), and 1 (1.9%), respectively. This website provides various information regarding biosimilars in Japan. It will be more important to effort the understanding and education for the healthcare providers and patients on biosimilar regulations. Moreover, information should be disseminated through the PMDA website of biosimilars to accelerate and ensure transparency regarding regulatory approvals and biosimilar regulations.
rights: © 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00210-025-03874-w
doi: 10.1007/s00210-025-03874-w
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kuribayashi R
      type: Person
      first name: Ryosuke
      last name: Kuribayashi
      member of: Office of Cellular and Tissue-based Products, Pharmaceuticals and Medical Devices Agency, 3-3-2, Kasumigaseki, Chiyoda-Ku, Tokyo, 100-0013, Japan. kuribayashi-ryosuke@pmda.go.jp.Office of Regulatory Science Research, Pharmaceuticals and Medical Devices Agency, 3-3-2, Kasumigaseki, Chiyoda-Ku, Tokyo, 100-0013, Japan. kuribayashi-ryosuke@pmda.go.jp.
  slot:
    index: 2
    item: Hariu A
      type: Person
      first name: Aya
      last name: Hariu
      member of: Office of Cellular and Tissue-based Products, Pharmaceuticals and Medical Devices Agency, 3-3-2, Kasumigaseki, Chiyoda-Ku, Tokyo, 100-0013, Japan.
  slot:
    index: 3
    item: Saino Y
      type: Person
      first name: Yuka
      last name: Saino
      member of: Office of Cellular and Tissue-based Products, Pharmaceuticals and Medical Devices Agency, 3-3-2, Kasumigaseki, Chiyoda-Ku, Tokyo, 100-0013, Japan.
  slot:
    index: 4
    item: Shinohara K
      type: Person
      first name: Kayo
      last name: Shinohara
      member of: Office of Cellular and Tissue-based Products, Pharmaceuticals and Medical Devices Agency, 3-3-2, Kasumigaseki, Chiyoda-Ku, Tokyo, 100-0013, Japan.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:14
e ISSN: 1432-1912
has issn l: 0028-1298
has NLM journal title abbreviation: Naunyn Schmiedebergs Arch Pharmacol
publication name: Naunyn-Schmiedeberg's archives of pharmacology
language: eng
has national library of medicine journal id: 0326264
derived from: NLM
has place of publication: Germany
source: Naunyn Schmiedebergs Arch Pharmacol. 2025-02-14;():.

Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients.
pmid: 39951118
abstract: This case-control study looked at a total of 104 university students, 51 individuals with obesity, and 53 individuals as controls. Biochemical measurements by the colorimetric method include zinc and copper. Genetic analysis by the tetra primers ARMS-PCR was used for genotyping the rs180113 SNP in the MTHFR gene.Serum zinc levels were significantly higher in the obese group compared to the non-obese group (145.1 ± 24.89 ug/dl vs. 114.8 ± 29.44 ug/dl, p = 0.0133), while copper levels showed no significant difference. Genotyping revealed the rs1801133 polymorphism in the MTHFR gene is significantly associated with obesity, with the A allele more frequent in obese individuals (39.6% vs. 14.5%, p < 0.05).Zn and rs1801133 are associated with obesity, the A allele of rs1801133 SNP and the significant associations observed in different genetic models highlight the potential of this polymorphism as a genetic marker for obesity risk.
doi: 10.1080/13813455.2025.2465338
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Alnaji HA
      type: Person
      first name: Haider Ali
      last name: Alnaji
      member of: Medical Laboratory Department, Kufa Institute, Al-Furat Al-Awsat Technical University, Najaf, Iraq.Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
  slot:
    index: 2
    item: Abduljaleel AK
      type: Person
      first name: Alkarar K
      last name: Abduljaleel
      member of: Medical Laboratory Department, Kufa Institute, Al-Furat Al-Awsat Technical University, Najaf, Iraq.
  slot:
    index: 3
    item: Al-Saadi T
      type: Person
      first name: Taif
      last name: Al-Saadi
      member of: Medical Laboratory Department, Kufa Institute, Al-Furat Al-Awsat Technical University, Najaf, Iraq.
  slot:
    index: 4
    item: Almulla AF
      type: Person
      first name: Abbas F
      last name: Almulla
      member of: Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:14
e ISSN: 1744-4160
has issn l: 1381-3455
has NLM journal title abbreviation: Arch Physiol Biochem
publication name: Archives of physiology and biochemistry
language: eng
has national library of medicine journal id: 9510153
derived from: NLM
starting page: 1
ending page: 8
has place of publication: England
source: Arch Physiol Biochem. 2025-02-14;():1-8.

Jak inhibitor intraclass switch in Alopecia Areata patients: a retrospective review of cases at an academic center.
pmid: 39951119
has PII: 10.1007/s00403-025-03848-1
doi: 10.1007/s00403-025-03848-1
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Silva I
      type: Person
      first name: Isabel
      last name: Silva
      member of: The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
  slot:
    index: 2
    item: Khattri S
      type: Person
      first name: Saakshi
      last name: Khattri
      member of: The Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA. saakshi.khattri@mountsinai.org.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:14
e ISSN: 1432-069X
has issn l: 0340-3696
issue: 1
has NLM journal title abbreviation: Arch Dermatol Res
publication name: Archives of dermatological research
language: eng
has national library of medicine journal id: 8000462
derived from: NLM
pg: 411
has place of publication: Germany
source: Arch Dermatol Res. 2025-02-14;317(1):411.
volume: 317

Lower Educational Attainment Widens Racial/Ethnic Disparities in Alcohol Use Disorder.
pmid: 39951124
abstract: Lower education is a risk factor for alcohol-related deaths, but it is unknown if the impact of education varies by race/ethnicity. We evaluated the interaction between education and race/ethnicity on the odds of alcohol use disorder (AUD) and the significance of employment and poverty as potential mediators.The 2016-19 National Survey on Drug Use and Health was used to obtain weighted prevalence of AUD in participants 26+ years. Using AUD as the outcome, multivariable logistic regression analyses were performed, stratified by four levels of education, ranging from less than high school (<HS) to 4-year college+ (4C); odds ratios (ORs) for each race/ethnicity were compared across models for interaction. The second model included employment and poverty as co-variates; changes in ORs were calculated to assess for >|10%| change implying significant mediating or confounding effect.AUD prevalence was highest among American Indian/Native Alaskans (AI/ANs) (8.06%), and similar among non-Hispanic Whites (5.37%) and Blacks (5.09%). When stratified by education, the odds of AUD among Blacks and AI/ANs increased with decreasing education [(OR 1.45, 95% CI 1.07-1.96) for Blacks v. Whites with <HS, compared to 0.55 (0.46-0.67) for Blacks v. Whites with 4C; 2.55 (1.53-4.24) for AI/ANs v. Whites with <HS v. 1.01 (0.45-2.28) for AI/ANs v. Whites with 4C). Including employment and poverty resulted in <|10%| change in ORs.Lower education significantly increased the odds of AUD among Blacks and AI/ANs. Employment and poverty did not significantly change the association, implying there are likely other mechanisms accounting for racial/ethnic disparities in AUD.
doi: 10.15288/jsad.24-00377
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kim-Vences SIH
      type: Person
      first name: Sung In H
      last name: Kim-Vences
      member of: Department of Family and Community Medicine, Baylor College of Medicine.Department of General Internal Medicine, Baylor College of Medicine.
  slot:
    index: 2
    item: Zoorob RJ
      type: Person
      first name: Roger J
      last name: Zoorob
      member of: Department of Family and Community Medicine, Baylor College of Medicine.
  slot:
    index: 3
    item: Hirth JM
      type: Person
      first name: Jacqueline M
      last name: Hirth
      member of: Department of Family and Community Medicine, Baylor College of Medicine.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:14
e ISSN: 1938-4114
has issn l: 1937-1888
has NLM journal title abbreviation: J Stud Alcohol Drugs
publication name: Journal of studies on alcohol and drugs
language: eng
has national library of medicine journal id: 101295847
derived from: NLM
has place of publication: United States
source: J Stud Alcohol Drugs. 2025-02-14;():.

Prevalence of Impostor Phenomenon in Graduate Healthcare Students.
pmid: 39951128
has PII: 00001416-202503001-00001
doi: 10.1097/JTE.0000000000000407
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T11:14
e ISSN: 1938-3533
has issn l: 0899-1855
issue: S1
has NLM journal title abbreviation: J Phys Ther Educ
publication name: Journal, physical therapy education
language: eng
has national library of medicine journal id: 9306054
derived from: NLM
starting page: 1
ending page: 172
has place of publication: United States
source: J Phys Ther Educ. 2025-03-01;39(S1):1-172.
volume: 39

A Child With a Pericardial Mass and Effusion: A Unique Presentation of a Rare Disease.
pmid: 39951141
has PII: 00006454-202503000-00024
doi: 10.1097/INF.0000000000004624
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Braiman N
      type: Person
      first name: Nika
      last name: Braiman
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.
  slot:
    index: 2
    item: Birk E
      type: Person
      first name: Einat
      last name: Birk
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.Institute of Pediatric Cardiology.
  slot:
    index: 3
    item: Levy D
      type: Person
      first name: David
      last name: Levy
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.Pediatric Infectious Disease Unit.
  slot:
    index: 4
    item: Weissbach A
      type: Person
      first name: Avichai
      last name: Weissbach
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.Pediatric Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
  slot:
    index: 5
    item: Kadmon G
      type: Person
      first name: Gili
      last name: Kadmon
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.Pediatric Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
  slot:
    index: 6
    item: Nahum E
      type: Person
      first name: Elhanan
      last name: Nahum
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.Pediatric Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
  slot:
    index: 7
    item: Kaplan E
      type: Person
      first name: Eytan
      last name: Kaplan
      member of: From the School of Medicine, Faculty of Medical Health Sciences, Tel-Aviv University, Tel-Aviv.Pediatric Intensive Care Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T11:15
e ISSN: 1532-0987
has issn l: 0891-3668
issue: 3
has NLM journal title abbreviation: Pediatr Infect Dis J
publication name: The Pediatric infectious disease journal
language: eng
has national library of medicine journal id: 8701858
derived from: NLM
starting page: 277
ending page: 280
has place of publication: United States
source: Pediatr Infect Dis J. 2025-03-01;44(3):277-280.
volume: 44

Analyzing the ingredients, SPF, and cost of purported reef safe sunscreens from multiple retailers.
pmid: 39951133
has PII: 10.1007/s00403-025-03970-0
doi: 10.1007/s00403-025-03970-0
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Scheinkman R
      type: Person
      first name: Ryan
      last name: Scheinkman
      member of: Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Scheinkman@med.miami.edu.
  slot:
    index: 2
    item: Sharifi S
      type: Person
      first name: Sheila
      last name: Sharifi
      member of: Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  slot:
    index: 3
    item: Green D
      type: Person
      first name: Daniel
      last name: Green
      member of: Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
  slot:
    index: 4
    item: Nouri K
      type: Person
      first name: Keyvan
      last name: Nouri
      member of: Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:15
e ISSN: 1432-069X
has issn l: 0340-3696
issue: 1
has NLM journal title abbreviation: Arch Dermatol Res
publication name: Archives of dermatological research
language: eng
has national library of medicine journal id: 8000462
derived from: NLM
pg: 414
has place of publication: Germany
source: Arch Dermatol Res. 2025-02-14;317(1):414.
volume: 317

Molecular Characterization of Treponema pallidum pallidum in an Adolescent With Syphilitic Hepatitis.
pmid: 39951143
has PII: 00006454-202503000-00030
doi: 10.1097/INF.0000000000004611
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Garcia LN
      type: Person
      first name: Luciana Noemi
      last name: Garcia
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP) CONICET-GCBA, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.
  slot:
    index: 2
    item: Moroni S
      type: Person
      first name: Samanta
      last name: Moroni
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
  slot:
    index: 3
    item: Meijomil M
      type: Person
      first name: Magdalena
      last name: Meijomil
      member of: Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina.
  slot:
    index: 4
    item: Gonzalez N
      type: Person
      first name: Nicolas
      last name: Gonzalez
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
  slot:
    index: 5
    item: Lascano F
      type: Person
      first name: Fernanda
      last name: Lascano
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP) CONICET-GCBA, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.
  slot:
    index: 6
    item: Mangone F
      type: Person
      first name: Franco
      last name: Mangone
      member of: Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP) CONICET-GCBA, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.
  slot:
    index: 7
    item: Warszatska B
      type: Person
      first name: Belen
      last name: Warszatska
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
  slot:
    index: 8
    item: Moscatelli G
      type: Person
      first name: Guillermo
      last name: Moscatelli
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP) CONICET-GCBA, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.
  slot:
    index: 9
    item: Pando MA
      type: Person
      first name: María Angeles
      last name: Pando
      member of: Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina.
  slot:
    index: 10
    item: Altcheh JM
      type: Person
      first name: Jaime Marcelo
      last name: Altcheh
      member of: Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP) CONICET-GCBA, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina.
created: 2025-2-14T12:28
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T11:15
e ISSN: 1532-0987
has issn l: 0891-3668
issue: 3
has NLM journal title abbreviation: Pediatr Infect Dis J
publication name: The Pediatric infectious disease journal
language: eng
has national library of medicine journal id: 8701858
derived from: NLM
starting page: e111
ending page: e112
has place of publication: United States
source: Pediatr Infect Dis J. 2025-03-01;44(3):e111-e112.
volume: 44

Cutaneous Mycobacterium llatzerense Infection in an Immunocompetent Child.
pmid: 39951142
has PII: 00006454-202503000-00028
doi: 10.1097/INF.0000000000004625
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Cox J
      type: Person
      first name: Jennifer
      last name: Cox
      member of: Department of Paediatric Infectious Diseases and Immunology, Children's Health Ireland at Crumlin, Dublin, Ireland.
  slot:
    index: 2
    item: Ó Maoldomhnaigh C
      type: Person
      first name: Cilian
      last name: Ó Maoldomhnaigh
      member of: Department of Paediatric Infectious Diseases and Immunology, Children's Health Ireland at Crumlin, Dublin, Ireland.
  slot:
    index: 3
    item: Orr D
      type: Person
      first name: David
      last name: Orr
      member of: Department of Plastic Surgery, Children's Health Ireland at Crumlin, Dublin, Ireland.
  slot:
    index: 4
    item: O'Sullivan MJ
      type: Person
      first name: Maureen J
      last name: O'Sullivan
      member of: Department of Pathology, Children's Health Ireland at Crumlin, Dublin, Ireland.
  slot:
    index: 5
    item: Leahy TR
      type: Person
      first name: Timothy Ronan
      last name: Leahy
      member of: Department of Paediatric Infectious Diseases and Immunology, Children's Health Ireland at Crumlin, Dublin, Ireland.School of Medicine, University of Dublin, Trinity College, Dublin, Ireland.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-03-01
dp: 2025 Mar 01
created: 2025-2-14T11:15
e ISSN: 1532-0987
has issn l: 0891-3668
issue: 3
has NLM journal title abbreviation: Pediatr Infect Dis J
publication name: The Pediatric infectious disease journal
language: eng
has national library of medicine journal id: 8701858
derived from: NLM
starting page: e109
ending page: e110
has place of publication: United States
source: Pediatr Infect Dis J. 2025-03-01;44(3):e109-e110.
volume: 44

Computer adaptive testing strategies for the Edinburgh Postnatal Depression Scale (EPDS).
pmid: 39951150
abstract: Perinatal mood and anxiety disorders (PMADs) include depressive and anxiety disorders during pregnancy or postpartum and can have significant consequences for the parent, child, and family. When severe, these conditions can lead to suicide. Despite numerous policy efforts to improve screening, education, and referral structures, disparities in PMAD diagnosis and treatment still exists, particularly among racial and ethnic minorities. Computer Adaptive Testing (CAT) has been shown to improve the efficiency of screening by significantly reducing test length. This study evaluates whether applying CAT to the Edinburgh Postnatal Depression Scale (EPDS) maintains diagnostic accuracy while ensuring these methods do not exacerbate racial disparities in PMAD screening outcomes.Using real data simulation, we assessed three CAT-based short-form versions of the EPDS, derived from one-, two-, and three-factor item response theory models. We evaluated their diagnostic precision and examined potential racial disparities in false negative rates compared to the full-length EPDS.We demonstrate that estimated scores from three short versions of the EPDS administered through CAT-assuming one, two, and three-factor item response theory models-are more highly correlated with the full-length EPDS measure traditionally used to make clinical decisions (r's between 0.96 and 0.97) than the major depressive disorder subtest (CAT-MDD) from CAT-Mental Health (CAT-MH®) (r =.82), as previously reported. Importantly, the false negative rates of the CAT-implied diagnoses did not significantly vary between racial groups, indicating no evidence of racial bias in diagnostic accuracy.The CAT-based versions of the EPDS offers a promising solution for improving the efficiency of PMAD screening without sacrificing diagnostic precision or exacerbating racial groups. By reducing evaluation time, these tools could facilitate more widespread and equitable screening, enabling earlier diagnosis and treatment of [cell cut: 2033 characters, first 2000 kept]
rights: © 2025. The Author(s).
has PII: 10.1007/s00737-025-01562-5
doi: 10.1007/s00737-025-01562-5
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wong EF
      type: Person
      first name: Emily F
      last name: Wong
      member of: Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Emily.Wong@cshs.org.
  slot:
    index: 2
    item: Accortt EE
      type: Person
      first name: Eynav E
      last name: Accortt
      member of: Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  slot:
    index: 3
    item: Choi SW
      type: Person
      first name: Seung W
      last name: Choi
      member of: Department of Educational Psychology, The University of Texas at Austin, Austin, TX, USA.
  slot:
    index: 4
    item: Bright TJ
      type: Person
      first name: Tiffani J
      last name: Bright
      member of: Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:16
e ISSN: 1435-1102
has issn l: 1434-1816
has NLM journal title abbreviation: Arch Womens Ment Health
publication name: Archives of women's mental health
language: eng
has national library of medicine journal id: 9815663
rights holder: • Short versions of the Edinburgh Postnatal Depression Scale (EPDS) tool, if administered through computer adaptive testing (CAT), provide very close approximations of the full scale but may miss a small portion of patients who otherwise would have screened positive.• The CAT versions of the EPDS provide a closer approximation of the standard screening tool for perinatal mood and anxiety disorders (PMAD) than the CAT-Mental Health (CAT-MH®).• We recommend screening for suicidal ideation after the CAT-administered EPDS for all patients to minimize the number of missed diagnoses.
derived from: NLM
has place of publication: Austria
source: Arch Womens Ment Health. 2025-02-14;():.

Clinical characteristics of atopic dermatitis in Chinese adult patients.
pmid: 39951155
has PII: 10.1007/s00403-025-03940-6
doi: 10.1007/s00403-025-03940-6
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Li Z
      type: Person
      first name: Zizhuo
      last name: Li
      member of: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.
  slot:
    index: 2
    item: Li X
      type: Person
      first name: Xu
      last name: Li
      member of: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.
  slot:
    index: 3
    item: Zhang K
      type: Person
      first name: Kaoyuan
      last name: Zhang
      member of: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.Institute of Dermatology, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
  slot:
    index: 4
    item: Yu B
      type: Person
      first name: Bo
      last name: Yu
      member of: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.Institute of Dermatology, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
  slot:
    index: 5
    item: Zhang J
      type: Person
      first name: Jie
      last name: Zhang
      member of: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China.
  slot:
    index: 6
    item: Li Y
      type: Person
      first name: Yannan
      last name: Li
      member of: School of Population and Public Health, University of British Columbia, Vancouver, Canada.
  slot:
    index: 7
    item: Dou X
      type: Person
      first name: Xia
      last name: Dou
      member of: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China. drdouxia@163.com.Institute of Dermatology, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China. drdouxia@163.com.Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, China. drdouxia@163.com.
created: 2025-2-14T12:26
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:16
e ISSN: 1432-069X
has issn l: 0340-3696
issue: 1
has NLM journal title abbreviation: Arch Dermatol Res
publication name: Archives of dermatological research
language: eng
has national library of medicine journal id: 8000462
derived from: NLM
pg: 400
has place of publication: Germany
source: Arch Dermatol Res. 2025-02-14;317(1):400.
volume: 317

Association of serum vitamin D levels and psoriasis severity: an analysis of the US National health and nutrition examination survey.
pmid: 39951145
has PII: 10.1007/s00403-025-03949-x
doi: 10.1007/s00403-025-03949-x
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lim RK
      type: Person
      first name: Rachel K
      last name: Lim
      member of: Department of Dermatology, The Warren Alpert Medical School of Brown University, 339 Eddy St, Providence, RI, 02903, USA.
  slot:
    index: 2
    item: Woo S
      type: Person
      first name: Seungmin
      last name: Woo
      member of: Department of Dermatology, The Warren Alpert Medical School of Brown University, 339 Eddy St, Providence, RI, 02903, USA.
  slot:
    index: 3
    item: El Raheb S
      type: Person
      first name: Sherif
      last name: El Raheb
      member of: Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.
  slot:
    index: 4
    item: Qureshi AA
      type: Person
      first name: Abrar A
      last name: Qureshi
      member of: Department of Dermatology, The Warren Alpert Medical School of Brown University, 339 Eddy St, Providence, RI, 02903, USA.Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
  slot:
    index: 5
    item: Cho E
      type: Person
      first name: Eunyoung
      last name: Cho
      member of: Department of Dermatology, The Warren Alpert Medical School of Brown University, 339 Eddy St, Providence, RI, 02903, USA. eunyoung_cho@brown.edu.Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA. eunyoung_cho@brown.edu.Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. eunyoung_cho@brown.edu.
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:15
e ISSN: 1432-069X
has issn l: 0340-3696
issue: 1
has NLM journal title abbreviation: Arch Dermatol Res
publication name: Archives of dermatological research
language: eng
has national library of medicine journal id: 8000462
derived from: NLM
pg: 405
has place of publication: Germany
source: Arch Dermatol Res. 2025-02-14;317(1):405.
volume: 317

Optimizing AI-assisted communication in urology: potential and challenges.
pmid: 39951154
has PII: 10.1007/s00345-025-05508-5
doi: 10.1007/s00345-025-05508-5
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Fang Y
      type: Person
      first name: Yuekun
      last name: Fang
      member of: Department of Andrology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
  slot:
    index: 2
    item: Chen S
      type: Person
      first name: Shengyi
      last name: Chen
      member of: Department of Andrology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
  slot:
    index: 3
    item: Cheng B
      type: Person
      first name: Bin
      last name: Cheng
      member of: Department of Urology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, No.75, Jinxiu Road, Wenzhou, China. bincheng591@gmail.com.
created: 2025-2-14T12:27
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:16
e ISSN: 1433-8726
has issn l: 0724-4983
issue: 1
has NLM journal title abbreviation: World J Urol
publication name: World journal of urology
language: eng
has national library of medicine journal id: 8307716
derived from: NLM
pg: 122
has place of publication: Germany
source: World J Urol. 2025-02-14;43(1):122.
volume: 43

Correction: Carcinogenic Mechanisms of Hexavalent Chromium: from DNA Breaks to Chromosome Instability and Neoplastic Transformation.
pmid: 39951156
has PII: 10.1007/s40572-025-00480-z
doi: 10.1007/s40572-025-00480-z
creator: OrderedList
  length: 5
created: 2025-2-14T12:29
date last updated: 2025-02-14
issued: 2025-02-14
dp: 2025 Feb 14
created: 2025-2-14T11:16
e ISSN: 2196-5412
has issn l: 2196-5412
issue: 1
has NLM journal title abbreviation: Curr Environ Health Rep
publication name: Current environmental health reports
language: eng
has national library of medicine journal id: 101629387
derived from: NLM
pg: 12
has place of publication: Switzerland
source: Curr Environ Health Rep. 2025-02-14;12(1):12.
volume: 12

index: 29
item: Veldink JH
  type: Person
  first name: Jan Herman
  last name: Veldink
  member of: Department of Neurology, University Medical Centre Utrecht Brain Centre, Utrecht, Netherlands.

index: 30
item: Dobson R
  type: Person
  first name: Richard
  last name: Dobson
  member of: Department of Biostatistics and Health Informatics, King's College London, London, UK.Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.

index: 31
item: Rouleau GA
  type: Person
  first name: Guy A
  last name: Rouleau
  member of: Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.Department of Genetics, McGill University, Montreal, Quebec, Canada.

index: 32
item: Al-Chalabi A
  type: Person
  first name: Ammar
  last name: Al-Chalabi
  member of: Department of Basic and Clinical Neuroscience, King's College London, London, UK.Department of Neurology, King's College Hospital, London, UK.

index: 33
item: Farhan SMK
  type: Person
  first name: Sali M K
  last name: Farhan
  member of: Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada alfredo.iacoangeli@kcl.ac.uk sali.farhan@mcgill.ca.Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.Department of Genetics, McGill University, Montreal, Quebec, Canada.

index: 29
item: Pantel T
  type: Person
  first name: Tobias
  last name: Pantel
  member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

index: 30
item: Middelkamp M
  type: Person
  first name: Maximilian
  last name: Middelkamp
  member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

index: 31
item: Eicker SO
  type: Person
  first name: Sven Oliver
  last name: Eicker
  member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.Department of Spine and Scoliosis Surgery, Lubinus Clinicum, 24106 Kiel, Germany.

index: 32
item: Kattaa AH
  type: Person
  first name: Ahed H
  last name: Kattaa
  member of: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

index: 33
item: Park DJ
  type: Person
  first name: David J
  last name: Park
  member of: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

index: 34
item: Chang SD
  type: Person
  first name: Steven D
  last name: Chang
  member of: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

index: 35
item: Kilinc F
  type: Person
  first name: Fatma
  last name: Kilinc
  member of: Department of Neurosurgery, University Hospital Frankfurt, Frankfurt am Main, Germany.

index: 36
item: Czabanka M
  type: Person
  first name: Marcus
  last name: Czabanka
  member of: Department of Neurosurgery, University Hospital Frankfurt, Frankfurt am Main, Germany.

index: 37
item: Güresir E
  type: Person
  first name: Erdem
  last name: Güresir
  member of: Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.Comprehensive Cancer Center Central Germany, Partner Site Leipzig, Leipzig, Germany.