Can gut microbiota explain acute diverticulitis occurrence in patients with symptomatic uncomplicated diverticular disease?
pmid: 39764487
abstract: Why patients with symptomatic uncomplicated diverticular disease (SUDD) may develop acute diverticulitis (AD) is still unknown. We analyzed the gut microbiota (GM) in two SUDD patients, one who did experience SUDD recurrence but not AD occurrence (case 1) and one who did experience AD occurrence during follow-up (case 2). The GM of these patients showed differences in terms of phyla (Firmicutes and Bacteroidota in case 1; Actinobacteriota and Proteobacteria in case 2) and subgenera (Prevotella and Phascolarctobacterium in case 1 and Alloprevotella, Prevotella, Holdemanella, Turicibacter, Eubacterium eligens group, and Dialister in case 2). This novel insight may advance our ecological understanding of this complex disease.
rights: ©2025 BMFH Press.
has PII: 2024-068
doi: 10.12938/bmfh.2024-068
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Tursi A
      type: Person
      first name: Antonio
      last name: Tursi
      member of: Territorial Gastroenterology Service, Barletta-Andria-Trani Local Health Agency, 49 Via Torino, Andria 76123, Italy.Department of Medical and Surgical Sciences, School of Medicine, Catholic University, Rome, Italy.
  slot:
    index: 2
    item: Procaccianti G
      type: Person
      first name: Giorgia
      last name: Procaccianti
      member of: Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
  slot:
    index: 3
    item: D'Amico F
      type: Person
      first name: Federica
      last name: D'Amico
      member of: Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
  slot:
    index: 4
    item: DE Bastiani R
      type: Person
      first name: Rudi
      last name: DE Bastiani
      member of: GIGA-CP Italian Association for Primary Care Gastroenterology, Feltre, Italy.
  slot:
    index: 5
    item: Turroni S
      type: Person
      first name: Silvia
      last name: Turroni
      member of: Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 1
ending page: 3
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):1-3.
volume: 44

Effects of moderate beer consumption on immunity and the gut microbiome in immunosuppressed mice.
pmid: 39764488
abstract: Beer contains a variety of bioactive ingredients and trace elements that can regulate bodily functions, and moderate consumption of beer can enhance immune responses. This study aimed to investigate the potential benefits of moderate consumption of alcoholic or non-alcoholic beer on the gut microbiome, immunity, and intestinal barrier function in immunosuppressed BALB/c mice induced by cyclophosphamide (CTX). Model mice with CTX-induced immunosuppression were administered alcoholic or non-alcoholic beer or galacto-oligosaccharides (GOS) for 28 consecutive days. The GOS and beer intervention groups all showed alleviation of spleen tissue damage, an increased immune organ index, decreased gut inflammation, and reduced serum concentrations of D-lactic acid, lipopolysaccharide, and tumor necrosis factor α. High-throughput 16S rRNA gene sequencing revealed higher relative abundances of Firmicutes and Actinobacteriota, and lower relative abundances of Bacteroidota, Lactobacillus, and Bifidobacterium, in CTX mice than in normal control mice. In addition, Firmicutes showed lower abundance, while Desulfobacterota showed higher abundance in CTX mice with non-alcoholic beer intake than without it. Spearman correlation analysis indicated that Bacteroidota was negatively correlated with propionic acid and butyric acid, while Desulfobacterota was positively correlated with butyric acid. Proteobacteria was negatively correlated with acetic acid, propionic acid, isobutyric acid, and valeric acid. Helicobacter was positively correlated with valeric acid. In conclusion, this is one of the first studies to examine the modulatory effects of moderate alcohol consumption in immunocompromised mice. Our findings indicate that beer consumption can alter the gut microbiome and metabolites, enhancing immunity in mice.
rights: ©2025 BMFH Press.
has PII: 2024-045
doi: 10.12938/bmfh.2024-045
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hu S
      type: Person
      first name: Shumin
      last name: Hu
      member of: State Key Laboratory of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co., Ltd., Qingdao, Shandong, PR China.
  slot:
    index: 2
    item: Yin H
      type: Person
      first name: Hua
      last name: Yin
      member of: State Key Laboratory of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co., Ltd., Qingdao, Shandong, PR China.
  slot:
    index: 3
    item: Li X
      type: Person
      first name: Xiaxia
      last name: Li
      member of: Department of Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, PR China.
  slot:
    index: 4
    item: Fan M
      type: Person
      first name: Minghao
      last name: Fan
      member of: State Key Laboratory of Biological Fermentation Engineering of Beer, Tsingtao Brewery Co., Ltd., Qingdao, Shandong, PR China.
  slot:
    index: 5
    item: Li H
      type: Person
      first name: Huajun
      last name: Li
      member of: Department of Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, PR China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 32
ending page: 42
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):32-42.
volume: 44

Gut microbiota involvement in the effect of water-soluble dietary fiber on fatty liver and fibrosis.
pmid: 39764489
abstract: The beneficial effects of water-soluble dietary fiber on liver fat and fibrosis involve the gut microbiota; however, few epidemiological studies have investigated this association. This large-scale epidemiological study aimed to determine the effect of water-soluble dietary fiber intake on liver fat and fibrosis via gut microbiota for the general population. We divided low- and high-intake groups by median daily water-soluble dietary fiber intake and matched background factors by propensity score matching for sex and age. The high-intake group had lower controlled attenuation parameters, a lower fatty liver index, and a lower mac-2-binding protein glycosylated isomer level than the low-intake group. Furthermore, in the high-intake group, the prevalences of metabolic dysfunction-associated steatotic liver disease and cardiometabolic criteria were significantly lower than in the low-intake group. In the high-intake group, there were increases and decreases in 16 bacterial species. Of them, those belonging to Faecalibacterium and Gemmiger had higher relative abundances than the other species and had a negative correlation with the fatty liver index and its components triglyceride and glutamyl transpeptidase in a multivariate analysis adjusted for confounding factors. On the other hand, Dorea showed a significant negative correlation with liver stiffness measure, even though Dorea was decreased in the high-intake group. Faecalibacterium and Gemmiger are butyrate-producing bacteria, suggesting that water-soluble dietary fiber may inhibit fatty liver via gut butyric acid production.
rights: ©2025 BMFH Press.
has PII: 2024-046
doi: 10.12938/bmfh.2024-046
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Sato S
      type: Person
      first name: Satoshi
      last name: Sato
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 2
    item: Iino C
      type: Person
      first name: Chikara
      last name: Iino
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 3
    item: Chinda D
      type: Person
      first name: Daisuke
      last name: Chinda
      member of: Division of Endoscopy, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 4
    item: Sasada T
      type: Person
      first name: Takafumi
      last name: Sasada
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 5
    item: Soma G
      type: Person
      first name: Go
      last name: Soma
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 6
    item: Tateda T
      type: Person
      first name: Tetsuyuki
      last name: Tateda
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 7
    item: Furusawa K
      type: Person
      first name: Keisuke
      last name: Furusawa
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 8
    item: Yoshida K
      type: Person
      first name: Kenta
      last name: Yoshida
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 9
    item: Sawada K
      type: Person
      first name: Kaori
      last name: Sawada
      member of: Department of Preemptive Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 10
    item: Mikami T
      type: Person
      first name: Tatsuya
      last name: Mikami
      member of: Department of Preemptive Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 11
    item: Nakaji S
      type: Person
      first name: Shigeyuki
      last name: Nakaji
      member of: Department of Preemptive Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 12
    item: Sakuraba H
      type: Person
      first name: Hirotake
      last name: Sakuraba
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
  slot:
    index: 13
    item: Fukuda S
      type: Person
      first name: Shinsaku
      last name: Fukuda
      member of: Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 49
ending page: 57
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):49-57.
volume: 44

Impact of container type on the microbiome of airag, a Mongolian fermented mare's milk.
pmid: 39764490
abstract: Airag, a fermented mare's milk in Mongolia, exhibits diverse flavors and microbiota due to distinct production processes and environments in nomadic households. Recently, there has been a shift from the traditional cow skin container, 'khokhuur', to a plastic container for airag production, potentially impacting the microbiota and quality. To address this notion, we aimed to elucidate the differences in the microbiota between airag samples from a plastic container and those from a khokhuur. We collected airag samples produced using either a plastic container or khokhuur from three houses in Mogod Sum (county) in Bulgan Aimag (province) and analyzed the chemical and microbiome properties of the obtained samples. Compared with the khokhuur, the plastic containers exhibited high heat retention at night and boosted lactate production, which sustained a lower pH level in airag. A series of alpha diversity indices of airag microbiota were significantly higher in airag produced in khokhuurs than in those produced in the plastic containers. In particular, Lactobacillus helveticus was the most dominant species, accounting for more than 90% of the total population in airags produced in the plastic containers and khokhuur, whereas some other lactic acid bacteria species and environmental bacteria more colonized airags produced in khokhuurs. The khokhuur itself is likely a source of these bacterial species and likely provides a niche, and the wider volatility of temperature may allow the growth of this wide range of bacteria while maintaining a lower level of lactic acid fermentation.
rights: ©2025 BMFH Press.
has PII: 2024-023
doi: 10.12938/bmfh.2024-023
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Shinoda A
      type: Person
      first name: Akari
      last name: Shinoda
      member of: Division of Systems Bioengineering, Department of Bioresource and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
  slot:
    index: 2
    item: Koga Y
      type: Person
      first name: Yuri
      last name: Koga
      member of: Division of Systems Bioengineering, Department of Bioresource and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
  slot:
    index: 3
    item: Tsuchiya R
      type: Person
      first name: Ryouta
      last name: Tsuchiya
      member of: Organization for the Strategic Coordination of Research and Intellectual Properties, Meiji University, 1-9-1 Eifuku, Suginami-ku, Tokyo 168-8555, Japan.
  slot:
    index: 4
    item: Tserenpurev BO
      type: Person
      first name: Bat-Oyun
      last name: Tserenpurev
      member of: Information and Research Institute of Meteorology, Hydrology and Environment, Ulaanbaatar 15160, Mongolia.
  slot:
    index: 5
    item: Battsetseg B
      type: Person
      first name: Badgar
      last name: Battsetseg
      member of: Mongolian University of Life Sciences, Zaisan, Ulaanbaatar 17024, Mongolia.
  slot:
    index: 6
    item: Morinaga Y
      type: Person
      first name: Yuki
      last name: Morinaga
      member of: School of Commerce, Meiji University, 1-9-1 Eifuku, Suginami-ku, Tokyo 168-8555, Japan.
  slot:
    index: 7
    item: Nakayama J
      type: Person
      first name: Jiro
      last name: Nakayama
      member of: Division of Systems Bioengineering, Department of Bioresource and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 90
ending page: 99
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):90-99.
volume: 44

α-Lipoic acid increases phagocytosis of some lactic acid bacteria via modulation of CD36 expression.
pmid: 39764493
abstract: Phagocytosis by immunocompetent cells is a key role in the biological defense mechanism and is the starting point of the reaction that leads from innate to acquired immunity. Several studies have demonstrated that some lactic acid bacteria strains activate the innate and acquired immune systems of the host. However, further investigation of the mechanism and improvement of usefulness is needed because the effect differs depending on the type and strain of lactic acid bacteria. In this study, we focused on the phagocytosis to lactic acid bacteria and investigated changes in phagocytic activity in vitro using several species of lactic acid bacteria and α-lipoic acid, which was expected to enhance phagocytosis. As a result, we found that α-lipoic acid treatment increased phagocytosis in several lactic acid bacteria. Strains of lactic acid bacteria with increased phagocytosis were found to have decreased CD36 expression when lactic acid bacteria alone were used, and CD36 expression was restored when α-lipoic acid was used in combination, indicating a correlation between increased phagocytosis and CD36 expression. Furthermore, the combination of Lactococcus lactis subsp. hordniae NBRC 100931 and α-lipoic acid increased phagocytosis over time and enhanced IgA production. These results suggest that the combination of α-lipoic acid and lactic acid bacteria increases the phagocytosis capacity of immunocompetent cells and may enhance the immunostimulatory effects of lactic acid bacteria.
rights: ©2025 BMFH Press.
has PII: 2024-019
doi: 10.12938/bmfh.2024-019
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Nomura N
      type: Person
      first name: Naoto
      last name: Nomura
      member of: Narita Development Center, SSP Co., Ltd., 1143 Nanpeidai, Narita-shi, Chiba 286-8511, Japan.
  slot:
    index: 2
    item: Miyadai N
      type: Person
      first name: Nobuo
      last name: Miyadai
      member of: Narita Development Center, SSP Co., Ltd., 1143 Nanpeidai, Narita-shi, Chiba 286-8511, Japan.
  slot:
    index: 3
    item: Kawase I
      type: Person
      first name: Ichiro
      last name: Kawase
      member of: Local Brand R&D, SSP Co., Ltd., Opera City Tower, 3-20-2 Nishi Shinjuku, Shinjuku-ku, Tokyo 163-1488, Japan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 43
ending page: 48
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):43-48.
volume: 44

Additive effect of mixtures of multiple strains combining the effects of single strains on human gut microbiota in vitro.
pmid: 39764492
abstract: Probiotics exert their beneficial effects by improving the intestinal environment. Heat-inactivated probiotics may show similar effects. However, whether multi-strain mixtures (MSM) are better than single strains, irrespective of whether the bacteria are alive or dead, is unknown. In this study, we examined the gut-improving efficacy of an MSM consisting of four dead bacterial strains using an in vitro model that simulates the human gut environment. In the in vitro model, human feces were inoculated with a single-strain or MSM, and the microbial composition and fermentation products were assessed. The 16S rRNA gene sequences showed that the MSM tended to change the microbial community structure more than single strains. Furthermore, the results of a microbial diversity analysis showed that despite differences among single strains, the effect of the MSM increased with the abundance of any single strain. A similar trend was observed for fermentation products. These results suggested that the MSM made from dead bacteria exerted additive effects that may provide new health benefits to more people.
rights: ©2025 BMFH Press.
has PII: 2024-059
doi: 10.12938/bmfh.2024-059
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Tsujikawa Y
      type: Person
      first name: Yuji
      last name: Tsujikawa
      member of: Central Research Institute, Itoen Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, Japan.
  slot:
    index: 2
    item: Yamamoto J
      type: Person
      first name: Junya
      last name: Yamamoto
      member of: Central Research Institute, Itoen Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, Japan.
  slot:
    index: 3
    item: Fukuda I
      type: Person
      first name: Itsuko
      last name: Fukuda
      member of: Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan.
  slot:
    index: 4
    item: Sakane I
      type: Person
      first name: Iwao
      last name: Sakane
      member of: Central Research Institute, Itoen Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, Japan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 58
ending page: 69
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):58-69.
volume: 44

Action and immunomodulatory mechanisms, formulations, and safety concerns of probiotics.
pmid: 39764491
abstract: The global probiotics market has been continuously growing, driven by consumer demand for immune-enhancing functional foods, dietary supplements, and natural therapeutics for gastrointestinal and gut function-mediated diseases. Probiotic microorganisms represent a diverse group of strains with complex but generalized mechanistic patterns. This review describes the various immunomodulatory mechanisms by which probiotics exert their effects, including the competitive exclusion of pathogenic microbes, production of antimicrobial substances, modulation of the immune system, and improvement of gut barrier function. In addition, the various formulations and methods of delivery of probiotics and the safety concerns associated with these products are also discussed.
rights: ©2025 BMFH Press.
has PII: 2024-006
doi: 10.12938/bmfh.2024-006
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ashaolu TJ
      type: Person
      first name: Tolulope Joshua
      last name: Ashaolu
      member of: Institute for Global Health Innovations, Duy Tan University, Da Nang, 550000, Vietnam.Faculty of Medicine, Duy Tan University, Da Nang, 550000, Vietnam.
  slot:
    index: 2
    item: Greff B
      type: Person
      first name: Babett
      last name: Greff
      member of: Department of Food Science, Széchenyi István University, Mosonmagyaróvár, 9200, Hungary.
  slot:
    index: 3
    item: Varga L
      type: Person
      first name: László
      last name: Varga
      member of: Department of Food Science, Széchenyi István University, Mosonmagyaróvár, 9200, Hungary.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 4
ending page: 15
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):4-15.
volume: 44

Verification of an alteration in the gut microbiota that increases nutritional risk in patients on hemodialysis.
pmid: 39764494
abstract: In end-stage kidney disease requiring hemodialysis, patients at nutritional risk have a poor prognosis. The gut microbiota is important for maintaining the nutritional status of patients. However, it remains unclear whether an altered gut microbiota correlates with increased nutritional risk in patients undergoing hemodialysis. Therefore, we retrospectively analyzed patients who underwent hemodialysis at our hospital between April and December 2022. Nutritional risk was evaluated using the Geriatric Nutritional Risk Index (GNRI), and patients were divided into low- and high-GNRI groups. Patients' clinical conditions and alterations in the gut microbiota were compared between the two groups. The study included a total of 38 patients with moderate to severe frailty. The low-GNRI group had 18 patients, and the high-GNRI group had 20 patients. The low-GNRI group had more severely frail patients. Serum transthyretin, cholinesterase, total cholesterol, and β2-microglobulin were significantly lower in the low-GNRI group than in the high-GNRI group. Significant differences in the relative abundances of the Actinobacteria and Proteobacteria phyla were observed between the two groups. The genus Bifidobacterium was significantly less abundant in the high-GNRI group than in the low-GNRI group. At the species level, Bifidobacterium adolescentis and Bifidobacterium bifidum were significantly lower in the low-GNRI group. Our results indicated that GNRI can be a useful nutritional risk index that accurately reflects the comprehensive differences in clinical condition in patients undergoing hemodialysis. The deficiency of B. adolescentis and B. bifidum was strongly associated with an increased nutritional risk in patients undergoing hemodialysis.
rights: ©2025 BMFH Press.
has PII: 2024-048
doi: 10.12938/bmfh.2024-048
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Fukuhara S
      type: Person
      first name: Sotaro
      last name: Fukuhara
      member of: Department of Surgery, National Hospital Organization Yanai Medical Center, 95 Ihonosho, Yamaguchi 742-1352, Japan.Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
  slot:
    index: 2
    item: Ohmori H
      type: Person
      first name: Hiromitsu
      last name: Ohmori
      member of: Department of Pediatrics, National Hospital Organization Yanai Medical Center, 95 Ihonosho, Yamaguchi 742-1352, Japan.
  slot:
    index: 3
    item: Matsumoto T
      type: Person
      first name: Tomio
      last name: Matsumoto
      member of: Department of Surgery, National Hospital Organization Yanai Medical Center, 95 Ihonosho, Yamaguchi 742-1352, Japan.
  slot:
    index: 4
    item: Takei D
      type: Person
      first name: Daisuke
      last name: Takei
      member of: Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
  slot:
    index: 5
    item: Matsuoka K
      type: Person
      first name: Koji
      last name: Matsuoka
      member of: Department of Surgery, National Hospital Organization Yanai Medical Center, 95 Ihonosho, Yamaguchi 742-1352, Japan.
  slot:
    index: 6
    item: Takemoto M
      type: Person
      first name: Masahiko
      last name: Takemoto
      member of: Department of Surgery, National Hospital Organization Yanai Medical Center, 95 Ihonosho, Yamaguchi 742-1352, Japan.
  slot:
    index: 7
    item: Sumimoto R
      type: Person
      first name: Ryo
      last name: Sumimoto
      member of: Department of Surgery, National Hospital Organization Yanai Medical Center, 95 Ihonosho, Yamaguchi 742-1352, Japan.
  slot:
    index: 8
    item: Ohdan H
      type: Person
      first name: Hideki
      last name: Ohdan
      member of: Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 26
ending page: 31
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):26-31.
volume: 44

α-Cyclodextrin supplementation improves endurance exercise performance and reduces post-exercise fatigue in human males: a randomized, double-blind, placebo-controlled, parallel-group study.
pmid: 39764495
abstract: α-Cyclodextrin (αCD), a cyclic hexasaccharide composed of six glucose units, is not digested in the small intestine but is completely fermented by gut microbes. Recently, we have reported that αCD supplementation for nonathlete men improved their 10 km biking times. However, the beneficial effects of αCD on exercise are not yet fully understood. Therefore, we conducted a randomized, double-blind, placebo-controlled, parallel-group study to confirm the reproducibility and obtain additional data, employing a larger sample size and a greater αCD dose than that used in our previous study. Age, body mass index, estimated V̇O2 max, and Bacteroides uniformis cell number in feces were used as stratifying factors. Eighty-one healthy nonathlete men aged 20 to 49 years who had exercise habits received a placebo (n=42) or αCD (1 g/day; n=39) for 9 weeks. Similar to our previous study, αCD supplementation significantly improved endurance exercise performance (10 km biking time trial) compared with the placebo (placebo=1,126.4 ± 133.6 s, αCD=1,073.2 ± 116.7 s, p=0.016). In addition, we observed a significantly reduced visual analog scale score for post-exercise fatigue (placebo=59.0 [46.3-54.3] mm, αCD=48.8 [37.0-50.3] mm, p=0.043). The heart rate increase was lower in the αCD group than in the placebo group during exercise (placebo=152.3 ± 11.1 bpm, αCD=144.2 ± 16.3 bpm, p=0.016). These results indicate that αCD supplementation improves endurance exercise performance and reduces post-exercise fatigue in nonathlete men.
rights: ©2025 BMFH Press.
has PII: 2024-062
doi: 10.12938/bmfh.2024-062
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Onishi M
      type: Person
      first name: Makiko
      last name: Onishi
      member of: Department of Group Project Strategy, Asahi Quality & Innovations, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan.
  slot:
    index: 2
    item: Nakamura T
      type: Person
      first name: Teppei
      last name: Nakamura
      member of: Department of Corporate Strategy, Asahi Quality & Innovations, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan.
  slot:
    index: 3
    item: Kano C
      type: Person
      first name: Chie
      last name: Kano
      member of: Core Technology Laboratories, Asahi Quality & Innovations, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan.
  slot:
    index: 4
    item: Hirota T
      type: Person
      first name: Tatsuhiko
      last name: Hirota
      member of: Core Technology Laboratories, Asahi Quality & Innovations, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan.
  slot:
    index: 5
    item: Fukuda S
      type: Person
      first name: Shinji
      last name: Fukuda
      member of: Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka-shi, Yamagata 997-0052, Japan.Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-0821, Japan.Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan.Laboratory for Regenerative Microbiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
  slot:
    index: 6
    item: Morita H
      type: Person
      first name: Hiroto
      last name: Morita
      member of: Core Technology Laboratories, Asahi Quality & Innovations, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 80
ending page: 89
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):80-89.
volume: 44

Application of the SpCas9 inhibitor BRD0539 for CRISPR/Cas9-based genetic tools in Lacticaseibacillus paracasei.
pmid: 39764496
abstract: Although the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas system has been extensively developed since its discovery for eukaryotic and prokaryotic genome editing and other genetic manipulations, there are still areas warranting improvement, especially regarding bacteria. In this study, BRD0539, a small-molecule inhibitor of Streptococcus pyogenes Cas9 (SpCas9), was used to suppress the activity of the nuclease during genetic modification of Lacticaseibacillus paracasei, as well as to regulate CRISPR interference (CRISPRi). First, we developed and validated a CRISPR-SpCas9 system targeting the sirA gene of L. paracasei. Then BRD0539 was used for CRISPR-dependent DNA cleavage in vivo. Our results suggested that the inhibitor worked partially in both Escherichia coli and L. paracasei. Next, we designed a CRISPRi system in a L. paracasei strain by inserting an inactive SpCas9 gene into the chromosome and introducing a plasmid encoding for a single guide RNA (sgRNA) targeting the sirA gene. Expression of sirA was successfully inhibited in the recombinant strains, and CRISPRi was abolished in an inhibitor-dependent manner. Our findings may help expand the CRISPR toolbox for research on lactic acid bacteria and other microbes.
rights: ©2025 BMFH Press.
has PII: 2024-009
doi: 10.12938/bmfh.2024-009
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Tamaki M
      type: Person
      first name: Mizuna
      last name: Tamaki
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 2
    item: Chiku T
      type: Person
      first name: Tsutomu
      last name: Chiku
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 3
    item: Suzuki S
      type: Person
      first name: Shunya
      last name: Suzuki
      member of: Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
  slot:
    index: 4
    item: Misaki A
      type: Person
      first name: Aya
      last name: Misaki
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 5
    item: Funakubo A
      type: Person
      first name: Asuka
      last name: Funakubo
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 6
    item: Matsushima Y
      type: Person
      first name: Yoshitaka
      last name: Matsushima
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 7
    item: Yokota K
      type: Person
      first name: Kenji
      last name: Yokota
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 8
    item: Igimi S
      type: Person
      first name: Shizunobu
      last name: Igimi
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
  slot:
    index: 9
    item: Kajikawa A
      type: Person
      first name: Akinobu
      last name: Kajikawa
      member of: Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025
dp: 2025
created: 2025-1-7T04:45
ISSN: 2186-6953
has issn l: 2186-3342
issue: 1
has NLM journal title abbreviation: Biosci Microbiota Food Health
publication name: Bioscience of microbiota, food and health
language: eng
has national library of medicine journal id: 101578264
derived from: NLM
starting page: 70
ending page: 79
has place of publication: Japan
source: Biosci Microbiota Food Health. 2025;44(1):70-79.
volume: 44

Viewpoint on 'Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in underdoped Bi2Sr2CaCu2O8+δ'.
pmid: 39764498
abstract: The experimental team achieves impressive progress in detecting the signature of the local magnetic response of a system close to a phase transition.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.
has PII: nwae376
doi: 10.1093/nsr/nwae376
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Babaev E
      type: Person
      first name: Egor
      last name: Babaev
      member of: Department of Physics, KTH Royal Institute of Technology, Sweden.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:45
e ISSN: 2053-714X
has issn l: 2053-714X
issue: 1
has NLM journal title abbreviation: Natl Sci Rev
publication name: National science review
language: eng
has national library of medicine journal id: 101633095
derived from: NLM
pg: nwae376
has place of publication: China
source: Natl Sci Rev. 2025-01;12(1):nwae376.
volume: 12

Experimental revival of an unknown state from the past in quantum walks.
pmid: 39764499
abstract: The physical process in the macroscopic world unfolds along a single time direction, while the evolution of a quantum system is reversible in principle. How to recover a quantum system to its past state is a complex issue of both fundamental and practical interests. In this article, we experimentally demonstrate a novel method for recovering the state in quantum walks (QWs), also known as full-state revival. Moreover, we observe two other important phenomena in QWs, recurrence and periodicity, via simplifying and repeatedly implementing the scheme, respectively. Our experiments show that obtaining these phenomena requires neither any information of the initial state nor full information of the coin operations. Our work sheds new light on quantum state engineering and recovery, and the initialization of quantum devices based on QWs.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.
has PII: nwae263
doi: 10.1093/nsr/nwae263
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Huo B
      type: Person
      first name: Bingzi
      last name: Huo
      member of: Beijing Computational Science Research Center, Beijing 100193, China.
  slot:
    index: 2
    item: Qu D
      type: Person
      first name: Dengke
      last name: Qu
      member of: Beijing Computational Science Research Center, Beijing 100193, China.
  slot:
    index: 3
    item: Lin Q
      type: Person
      first name: Quan
      last name: Lin
      member of: School of Physics, Southeast University, Nanjing 211189, China.
  slot:
    index: 4
    item: Zhu G
      type: Person
      first name: Gaoyan
      last name: Zhu
      member of: College of Electronic and Information Engineering, Shandong University of Science and Technology, Qingdao 266590, China.
  slot:
    index: 5
    item: Xiao L
      type: Person
      first name: Lei
      last name: Xiao
      member of: School of Physics, Southeast University, Nanjing 211189, China.
  slot:
    index: 6
    item: Zhan X
      type: Person
      first name: Xiang
      last name: Zhan
      member of: School of Physics, Southeast University, Nanjing 211189, China.
  slot:
    index: 7
    item: Xue P
      type: Person
      first name: Peng
      last name: Xue
      member of: Beijing Computational Science Research Center, Beijing 100193, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:45
e ISSN: 2053-714X
has issn l: 2053-714X
issue: 1
has NLM journal title abbreviation: Natl Sci Rev
publication name: National science review
language: eng
has national library of medicine journal id: 101633095
derived from: NLM
pg: nwae263
has place of publication: China
source: Natl Sci Rev. 2025-01;12(1):nwae263.
volume: 12

Cooler, stronger, smaller: improving thermoelectric cooling.
pmid: 39764500
has PII: nwae445
doi: 10.1093/nsr/nwae445
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Chauhan NS
      type: Person
      first name: Nagendra Singh
      last name: Chauhan
      member of: Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Japan.
  slot:
    index: 2
    item: Mori T
      type: Person
      first name: Takao
      last name: Mori
      member of: Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Japan.Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:45
e ISSN: 2053-714X
has issn l: 2053-714X
issue: 1
has NLM journal title abbreviation: Natl Sci Rev
publication name: National science review
language: eng
has national library of medicine journal id: 101633095
derived from: NLM
pg: nwae445
has place of publication: China
source: Natl Sci Rev. 2025-01;12(1):nwae445.
volume: 12

Complexity of social media in the era of generative AI.
pmid: 39764512
abstract: The article presents a perspective on how the emerging generative AI technology can shape social media and the new challenges in studying social media in this generative.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.
has PII: nwae323
doi: 10.1093/nsr/nwae323
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pan L
      type: Person
      first name: Liming
      last name: Pan
      member of: School of Cyber Science and Technology, University of Science and Technology of China, China.
  slot:
    index: 2
    item: Wang CY
      type: Person
      first name: Chong-Yang
      last name: Wang
      member of: Institute of Fundamental and Frontier Studies and Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, China.
  slot:
    index: 3
    item: Zhou F
      type: Person
      first name: Fang
      last name: Zhou
      member of: Institute of Fundamental and Frontier Studies and Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, China.
  slot:
    index: 4
    item: Lü L
      type: Person
      first name: Linyuan
      last name: Lü
      member of: School of Cyber Science and Technology, University of Science and Technology of China, China.Institute of Fundamental and Frontier Studies and Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:45
e ISSN: 2053-714X
has issn l: 2053-714X
issue: 1
has NLM journal title abbreviation: Natl Sci Rev
publication name: National science review
language: eng
has national library of medicine journal id: 101633095
derived from: NLM
pg: nwae323
has place of publication: China
source: Natl Sci Rev. 2025-01;12(1):nwae323.
volume: 12

Characterization of 3,3'-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle.
pmid: 39764513
abstract: Utricle is an important vestibular sensory organ for maintaining balance. 3,3'-iminodipropionitrile (IDPN), a prototype nitrile toxin, has been reported to be neurotoxic and vestibulotoxic, and can be used to establish an in vivo damage model of vestibular dysfunction. However, the mechanism of utricular HCs damage caused by IDPN is unclear. Here, we first studied mice balance behavior and HCs damage in IDPN utricle damage model, and found that IDPN injection in vivo can cause vestibular dysfunction and HCs damage, which is more pronounced than neomycin damage model. Then we used RNA-seq to characterize the transcriptome of IDPN damaged utricle in detail to identify genes and pathways that play roles in this process. We found 1,165 upregulated genes and 1,043 downregulated genes in IDPN damaged utricles, and identified that NF-κB pathway and TNF pathway may play important roles in IDPN damage model. Our study provides details of transcriptome of IDPN utricle damage model for further study of vestibular dysfunction.
rights: Copyright © 2024 Tian, Huang, Xiao, Jiang, Ma, Lin, Tang, Wang, Dai, Tong, Ye, Sheng, Chai and Zhang.
doi: 10.3389/fnmol.2024.1487364
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Tian M
      type: Person
      first name: Mengyao
      last name: Tian
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 2
    item: Huang J
      type: Person
      first name: Jingyuan
      last name: Huang
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 3
    item: Xiao H
      type: Person
      first name: Hairong
      last name: Xiao
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 4
    item: Jiang P
      type: Person
      first name: Pei
      last name: Jiang
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 5
    item: Ma X
      type: Person
      first name: Xiangyu
      last name: Ma
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 6
    item: Lin Y
      type: Person
      first name: Yanqin
      last name: Lin
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 7
    item: Tang X
      type: Person
      first name: Xujun
      last name: Tang
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 8
    item: Wang Y
      type: Person
      first name: Yintao
      last name: Wang
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 9
    item: Dai M
      type: Person
      first name: Mingchen
      last name: Dai
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 10
    item: Tong W
      type: Person
      first name: Wei
      last name: Tong
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 11
    item: Ye Z
      type: Person
      first name: Zixuan
      last name: Ye
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
  slot:
    index: 12
    item: Sheng X
      type: Person
      first name: Xia
      last name: Sheng
      member of: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Environmental Health, School of Environmental Science and Engineering, Hainan University, Haikou, China.
  slot:
    index: 13
    item: Chai R
      type: Person
      first name: Renjie
      last name: Chai
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China.Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China.
  slot:
    index: 14
    item: Zhang S
      type: Person
      first name: Shasha
      last name: Zhang
      member of: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.Southeast University, Shenzhen Research Institute, Shenzhen, China.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:45
ISSN: 1662-5099
has issn l: 1662-5099
has NLM journal title abbreviation: Front Mol Neurosci
publication name: Frontiers in molecular neuroscience
language: eng
has national library of medicine journal id: 101477914
derived from: NLM
pg: 1487364
has place of publication: Switzerland
source: Front Mol Neurosci. 2024;17():1487364.
volume: 17

Vascular ultrasound diagnosis and clinical implications of aberrant anterior tibial artery: case report.
pmid: 39764515
abstract: The lower limb is vascularized by the femoral artery, which continues as the popliteal artery. After the distal margin of the popliteus muscle, the popliteal artery divides into the anterior and posterior tibial arteries. Anatomical variations in the bifurcation of the popliteal artery are frequent. One such variation is the aberrant anterior tibial artery, in which the artery runs anterior to the popliteus muscle instead of following the normal dorsal course. We report a case in which this anatomical variation was diagnosed with vascular ultrasound in a patient complaining of intermittent claudication in the left lower limb. The examination ruled out any possibility of obstructive arterial injury and identified a high bifurcation of the popliteal artery and the anterior tibial artery running anterior to the popliteus muscle and the tibial cortex. This anomalous variation is of great clinical importance, especially in surgical procedures involving the knee. Surgical injury to these arteries can lead to formation of pseudoaneurysm, compartment syndrome, or necrosis and can even result in limb amputation.
rights: Copyright© 2024 The authors.
has PII: jvbRC20240030_PT
doi: 10.1590/1677-5449.202400302
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: França MJ
      type: Person
      first name: Mariana Jordão
      last name: França
      member of: Universidade Positivo - UP, Curitiba, PR, Brasil.
  slot:
    index: 2
    item: Takahashi LA
      type: Person
      first name: Luciana Akemi
      last name: Takahashi
      member of: Universidade Federal do Paraná - UFPR, Complexo do Hospital de Clínicas - CHC, Curitiba, PR, Brasil.
  slot:
    index: 3
    item: França GJ
      type: Person
      first name: Graciliano José
      last name: França
      member of: Universidade Positivo - UP, Curitiba, PR, Brasil.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:45
e ISSN: 1677-7301
has issn l: 1677-5449
has NLM journal title abbreviation: J Vasc Bras
publication name: Jornal vascular brasileiro
language: eng
has national library of medicine journal id: 101262256
derived from: NLM
pg: e20240030
has place of publication: Brazil
source: J Vasc Bras. 2024;23():e20240030.
volume: 23

Surgical management of ulnar artery aneurysm in hypothenar hammer syndrome.
pmid: 39764516
abstract: Ulnar artery aneurysms are extremely rare and are mainly associated with hypothenar hammer syndrome, an ischemic disorder of the hand resulting from mechanical and repetitive trauma to the hypothenar region. The ulnar artery is hit against the hook of the hamate bone, causing damage to the vessel wall and leading to occlusion or formation of an aneurysm. We describe the case of a truck driver who underwent resection of an ulnar artery aneurysm in the right hand and reconstruction using end-to-end anastomosis with no complications or recurrence.
rights: Copyright© 2024 The authors.
has PII: jvbDT20240016_PT
doi: 10.1590/1677-5449.202400162
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Dos Santos JA
      type: Person
      first name: Jonas Almeida
      last name: Dos Santos
      member of: Universidade Federal do Ceará - UFC, Hospital Universitário Walter Cantídio - HUWC, Fortaleza, CE, Brasil.
  slot:
    index: 2
    item: Themótheo FM
      type: Person
      first name: Florice de Matos
      last name: Themótheo
      member of: Universidade Federal do Ceará - UFC, Hospital Universitário Walter Cantídio - HUWC, Fortaleza, CE, Brasil.
  slot:
    index: 3
    item: Nunes PHS
      type: Person
      first name: Paulo Henrique Silva
      last name: Nunes
      member of: Universidade Federal do Ceará - UFC, Fortaleza, CE, Brasil.
  slot:
    index: 4
    item: Campelo MWS
      type: Person
      first name: Marcio Wilker Soares
      last name: Campelo
      member of: Universidade Federal do Ceará - UFC, Hospital Universitário Walter Cantídio - HUWC, Fortaleza, CE, Brasil.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:45
e ISSN: 1677-7301
has issn l: 1677-5449
has NLM journal title abbreviation: J Vasc Bras
publication name: Jornal vascular brasileiro
language: eng
has national library of medicine journal id: 101262256
derived from: NLM
pg: e20240016
has place of publication: Brazil
source: J Vasc Bras. 2024;23():e20240016.
volume: 23

Post-transcriptional regulation of the transcriptional apparatus in neuronal development.
pmid: 39764514
abstract: Post-transcriptional mechanisms, such as alternative splicing and polyadenylation, are recognized as critical regulatory processes that increase transcriptomic and proteomic diversity. The advent of next-generation sequencing and whole-genome analyses has revealed that numerous transcription and epigenetic regulators, including transcription factors and histone-modifying enzymes, undergo alternative splicing, most notably in the nervous system. Given the complexity of regulatory processes in the brain, it is conceivable that many of these splice variants control different aspects of neuronal development. Mutations or dysregulation of splicing and transcription regulatory proteins are frequently linked to various neurodevelopmental disorders, highlighting the importance of understanding the role of neuron-specific alternative splicing in maintaining proper transcriptional regulation in the brain. This review consolidates current insights into the role of alternative splicing in influencing transcriptional and chromatin regulatory programs in neuronal development.
rights: Copyright © 2024 Nazim.
doi: 10.3389/fnmol.2024.1483901
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Nazim M
      type: Person
      first name: Mohammad
      last name: Nazim
      member of: Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:45
ISSN: 1662-5099
has issn l: 1662-5099
has NLM journal title abbreviation: Front Mol Neurosci
publication name: Frontiers in molecular neuroscience
language: eng
has national library of medicine journal id: 101477914
derived from: NLM
pg: 1483901
has place of publication: Switzerland
source: Front Mol Neurosci. 2024;17():1483901.
volume: 17

Bilateral avascular necrosis leading to hip fracture in pregnancy: A case report.
pmid: 39764518
abstract: Avascular necrosis (AVN) of the hip, a rare cause of pelvic pain in the third trimester of pregnancy, often presents with nonspecific symptoms that resemble common musculoskeletal conditions. This ambiguity, coupled with concerns about the safety of magnetic resonance imaging (MRI) during pregnancy, can hinder timely diagnosis. We report a unique case of a 32-year-old primigravida diagnosed with a hip fracture and bilateral AVN of the femoral head in the immediate postpartum period, a complication seemingly not previously documented in pregnant patients. The initial management involved closed reduction and internal fixation using cannulated screws. However, progressive femoral head collapse necessitated revision to a total hip arthroplasty. This case underscores the importance of early diagnosis and recognition of AVN in pregnancy to prevent severe complications. It highlights the diagnostic challenges and emphasizes the need for heightened awareness and earlier imaging investigations in similar clinical scenarios.
rights: © 2024 The Authors.
has PII: S2214-9112(24)00096-1
doi: 10.1016/j.crwh.2024.e00675
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mencia MM
      type: Person
      first name: Marlon M
      last name: Mencia
      member of: Department of Clinical Surgical Sciences, The University of the West Indies, Trinidad and Tobago.
  slot:
    index: 2
    item: Cruz PPH
      type: Person
      first name: Pedro Pablo Hernandez
      last name: Cruz
      member of: Department of Surgery, Port-of-Spain General Hospital, Port of Spain, Trinidad and Tobago.
  slot:
    index: 3
    item: Bidaisee S
      type: Person
      first name: Shanta
      last name: Bidaisee
      member of: Department of Surgery, Port-of-Spain General Hospital, Port of Spain, Trinidad and Tobago.
  slot:
    index: 4
    item: Beharry A
      type: Person
      first name: Allan
      last name: Beharry
      member of: Department of Surgery, Port-of-Spain General Hospital, Port of Spain, Trinidad and Tobago.
created: 2025-1-7T06:21
date last updated: 2025-01-07
issued: 2025-03
dp: 2025 Mar
created: 2025-1-7T04:45
e ISSN: 2214-9112
has issn l: 2214-9112
has NLM journal title abbreviation: Case Rep Womens Health
publication name: Case reports in women's health
language: eng
has national library of medicine journal id: 101682122
derived from: NLM
pg: e00675
has place of publication: Netherlands
source: Case Rep Womens Health. 2025-03;45():e00675.
volume: 45

Using visual storytelling to share aggregate findings with families participating in clinical genomics research.
pmid: 39764519
abstract: Sharing aggregate results with research participants is a widely agreed-upon ethical obligation; yet, there is little research on communicating study results to diverse populations enrolled in genomics research. This article describes the cocreation of a visual narrative to explain research findings to families enrolled in a clinical genomics research study.The design process involved researchers, clinicians, study participants, a physician illustrator, and a health communications expert. Drawing on themes identified in interviews with participating families, the team developed a story and comic about a fictional family participating in genomic research in the hopes of finding an explanation for their child's condition.Design adjustments to improve the clarity and relatability of the story and accompanying images were prompted by feedback from study participants, who showed a high degree of interest in and support for the project. Spanish and English versions of the final comic book were distributed to study participants, and the feedback received was positive.Our project highlights the feasibility of using visual storytelling to convey genomic research findings to socioeconomically diverse participants. A participatory design process enhances the relevance and relatability of results sharing materials and demonstrates respect for those who contribute to clinical genomics research.
rights: © 2024 The Authors.
has PII: S2949-7744(24)00990-7
doi: 10.1016/j.gimo.2024.101844
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zamora AN
      type: Person
      first name: Astrid N
      last name: Zamora
      member of: Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA.UCSF Bioethics, University of California, San Francisco, CA.
  slot:
    index: 2
    item: Brown JEH
      type: Person
      first name: Julia E H
      last name: Brown
      member of: Institute for Health and Aging, University of California, San Francisco, CA.Department of Social and Behavioral Sciences, University of California, San Francisco, CA.
  slot:
    index: 3
    item: Outram S
      type: Person
      first name: Simon
      last name: Outram
      member of: UCSF Bioethics, University of California, San Francisco, CA.
  slot:
    index: 4
    item: Ackerman SL
      type: Person
      first name: Sara L
      last name: Ackerman
      member of: UCSF Bioethics, University of California, San Francisco, CA.Institute for Health and Aging, University of California, San Francisco, CA.Department of Social and Behavioral Sciences, University of California, San Francisco, CA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
e ISSN: 2949-7744
has issn l: 2949-7744
has NLM journal title abbreviation: Genet Med Open
publication name: Genetics in medicine open
language: eng
has national library of medicine journal id: 9918734281906676
derived from: NLM
pg: 101844
has place of publication: United States
source: Genet Med Open. 2024;2():101844.
volume: 2

SPI1 facilitates microfracture-mediated cartilage regeneration in the elderly by enhancing bone marrow stromal cells ctemness.
pmid: 39764517
abstract: Bone marrow stimulation treatment by bone marrow stromal cells (BMSCs) released from the bone medullary cavity and differentiated into cartilage via microfracture surgery is a frequently employed technique for treating articular cartilage injuries, yet the treatment presents a main drawback of poor cartilage regeneration in the elderly. Prior research indicated that aging could decrease the stemness capacity of BMSCs, thus we made a hypothesis that increasing old BMSCs (OBMSCs) stemness might improve the results of microfracture in the elderly. First, we investigated the correlation between microfracture outcomes and BMSCs stemness using clinical data and animal experiments. The outcomes of microfracture surgery in the elderly were significantly decreased as compared with the young counterparts while the stemness capacity of OBMSCs was also significantly decreased, and they were positively correlated. To investigate the role of BMSCs stemness in microfracture, we developed microfracture-mimic cartilage regeneration organoid models. In vitro experiments identified SPI1 as a potential stemness target gene, which could enhance the stemness and chondrogenesis of OBMSCs. The implantation of cartilage regeneration organoids made by SPI1-overexpressed OBMSCs could notably enhance cartilage regeneration in the old rats as compared with the microfracture treatment alone. Furthermore, molecular docking suggested a possible interaction between SPI1 and 5-Aza-2'-deoxycytidine (5Aza). The application of 5Aza could significantly improve the result of microfracture by upregulating SPI1. In summary, we identified SPI1 as a novel stemness target of OBMSCs, which was beneficial for the improvement of microfracture-stimulated cartilage regeneration in the elderly.
rights: © The Author(s) 2025.
has PII: 10.1177_20417314241311073
doi: 10.1177/20417314241311073
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Wang C
      type: Person
      first name: Changjiang
      last name: Wang
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  slot:
    index: 2
    item: Wang Y
      type: Person
      first name: Yishu
      last name: Wang
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  slot:
    index: 3
    item: Gu Y
      type: Person
      first name: Yueqiang
      last name: Gu
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  slot:
    index: 4
    item: Zhu Y
      type: Person
      first name: Yi
      last name: Zhu
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  slot:
    index: 5
    item: Yin R
      type: Person
      first name: Rui
      last name: Yin
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  slot:
    index: 6
    item: Li Y
      type: Person
      first name: Yang
      last name: Li
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
  slot:
    index: 7
    item: Gui J
      type: Person
      first name: Jianchao
      last name: Gui
      member of: Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
created: 2025-1-7T04:45
ISSN: 2041-7314
has issn l: 2041-7314
has NLM journal title abbreviation: J Tissue Eng
publication name: Journal of tissue engineering
language: eng
has national library of medicine journal id: 101550131
derived from: NLM
pg: 20417314241311073
has place of publication: England
source: J Tissue Eng. ;16():20417314241311073.
volume: 16

Precision animal husbandry: using artificial intelligence for camera traps to optimize animal production and management decision support systems.
pmid: 39764520
has PII: vfae026
doi: 10.1093/af/vfae026
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Burns A
      type: Person
      first name: Amira
      last name: Burns
      member of: USDA-ARS Range Sheep Production Efficiency Research Unit, Dubois, ID, USA.USDA-ARS SCINet Program and AI Center of Excellence, Beltsville, MD, USA.
  slot:
    index: 2
    item: Wilmer H
      type: Person
      first name: Hailey
      last name: Wilmer
      member of: USDA-ARS Range Sheep Production Efficiency Research Unit, Dubois, ID, USA.
  slot:
    index: 3
    item: Miller RS
      type: Person
      first name: Ryan S
      last name: Miller
      member of: Center for Epidemiology and Animal Health, USDA/APHIS/Veterinary Services, Fort Collins, CO, USA.
  slot:
    index: 4
    item: Clark PE
      type: Person
      first name: Patrick E
      last name: Clark
      member of: USDA-ARS Northwest Watershed Research Center, Boise, ID, USA.
  slot:
    index: 5
    item: Taylor JB
      type: Person
      first name: J Bret
      last name: Taylor
      member of: USDA-ARS Range Sheep Production Efficiency Research Unit, Dubois, ID, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 68
ending page: 71
has place of publication: England
source: Anim Front. 2024-12;14(6):68-71.
volume: 14

Artificial intelligence applied to dairy science: insights from the Dairy Brain Initiative.
pmid: 39764522
has PII: vfae040
doi: 10.1093/af/vfae040
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Cabrera VE
      type: Person
      first name: Victor E
      last name: Cabrera
      member of: Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United States.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 60
ending page: 63
has place of publication: England
source: Anim Front. 2024-12;14(6):60-63.
volume: 14

Generative artificial intelligence in extension: a new era of support for livestock producers.
pmid: 39764523
has PII: vfae024
doi: 10.1093/af/vfae024
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Prestegaard-Wilson J
      type: Person
      first name: Jacquelyn
      last name: Prestegaard-Wilson
      member of: Department of Animal Science; College Station, Texas A&M AgriLife Extension, TX, USA.
  slot:
    index: 2
    item: Vitale J
      type: Person
      first name: Jeffrey
      last name: Vitale
      member of: Department of Agricultural Economics; Stillwater, Oklahoma State University, OK, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 57
ending page: 59
has place of publication: England
source: Anim Front. 2024-12;14(6):57-59.
volume: 14

Preparing the AI-assisted animal scientist: faculty and student perspectives on enhancing animal science education with artificial intelligence.
pmid: 39764524
has PII: vfae038
doi: 10.1093/af/vfae038
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Baumhover A
      type: Person
      first name: Allison
      last name: Baumhover
      member of: Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA.
  slot:
    index: 2
    item: Hansen SL
      type: Person
      first name: Stephanie L
      last name: Hansen
      member of: Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 54
ending page: 56
has place of publication: England
source: Anim Front. 2024-12;14(6):54-56.
volume: 14

From reactive to proactive: impact of artificial intelligence on management and selection of livestock.
pmid: 39764525
has PII: vfae029
doi: 10.1093/af/vfae029
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Grohmann CJ
      type: Person
      first name: Caleb J
      last name: Grohmann
      member of: Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA.
  slot:
    index: 2
    item: Decker JE
      type: Person
      first name: Jared E
      last name: Decker
      member of: Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA.Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA.Genetics Area Program, University of Missouri, Columbia, MO 65211, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 64
ending page: 67
has place of publication: England
source: Anim Front. 2024-12;14(6):64-67.
volume: 14

Computer vision algorithms to help decision-making in cattle production.
pmid: 39764526
has PII: vfae028
doi: 10.1093/af/vfae028
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Guarnido-Lopez P
      type: Person
      first name: P
      last name: Guarnido-Lopez
      member of: Department of Animal Science, Texas A&M University, College Station, TX 77843-2471, USA.
  slot:
    index: 2
    item: Pi Y
      type: Person
      first name: Y
      last name: Pi
      member of: Institute of Data Science, Texas A&M University, College Station, TX, USA.
  slot:
    index: 3
    item: Tao J
      type: Person
      first name: J
      last name: Tao
      member of: Institute of Data Science, Texas A&M University, College Station, TX, USA.School of Performance, Visualization and Fine Arts & Institute of Data Science, Texas A&M University, College Station, TX, USA.
  slot:
    index: 4
    item: Mendes EDM
      type: Person
      first name: E D M
      last name: Mendes
      member of: Department of Animal Science, Texas A&M University, College Station, TX 77843-2471, USA.
  slot:
    index: 5
    item: Tedeschi LO
      type: Person
      first name: L O
      last name: Tedeschi
      member of: Department of Animal Science, Texas A&M University, College Station, TX 77843-2471, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 11
ending page: 22
has place of publication: England
source: Anim Front. 2024-12;14(6):11-22.
volume: 14

A peep into the future: artificial intelligence for on-farm poultry welfare monitoring.
pmid: 39764527
has PII: vfae031
doi: 10.1093/af/vfae031
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ajibola G
      type: Person
      first name: Gideon
      last name: Ajibola
      member of: Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.
  slot:
    index: 2
    item: Kilders V
      type: Person
      first name: Valerie
      last name: Kilders
      member of: Department of Agricultural Economics, Purdue University, West Lafayette, IN, USA.
  slot:
    index: 3
    item: Erasmus MA
      type: Person
      first name: Marisa A
      last name: Erasmus
      member of: Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 72
ending page: 75
has place of publication: England
source: Anim Front. 2024-12;14(6):72-75.
volume: 14

The role of artificial intelligence in Latin American ruminant production systems.
pmid: 39764528
has PII: vfae034
doi: 10.1093/af/vfae034
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Vargas-Bello-Pérez E
      type: Person
      first name: Einar
      last name: Vargas-Bello-Pérez
      member of: Facultad de Zootecnia y Ecología, Universidad Autónoma de Chihuahua, Chihuahua, México.Department of International Development, School of Agriculture, Policy and Development, University of Reading, Reading, UK.
  slot:
    index: 2
    item: Espinoza-Sandoval OR
      type: Person
      first name: Oscar R
      last name: Espinoza-Sandoval
      member of: Facultad de Zootecnia y Ecología, Universidad Autónoma de Chihuahua, Chihuahua, México.
  slot:
    index: 3
    item: Gonzalez Ronquillo M
      type: Person
      first name: Manuel
      last name: Gonzalez Ronquillo
      member of: Facultad de Medicina Veterinaria y Zootecnia, Departamento de Nutrición Animal, Universidad Autónoma del Estado de México, Toluca, México.
  slot:
    index: 4
    item: Angeles Hernandez JC
      type: Person
      first name: Juan Carlos
      last name: Angeles Hernandez
      member of: Departamento de Medicina y Zootenia de Rumiantes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City, CP. 04510, Mexico.
  slot:
    index: 5
    item: Chay-Canul AJ
      type: Person
      first name: Alfonso J
      last name: Chay-Canul
      member of: División Académica de Ciencias Agropecuarias, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.
  slot:
    index: 6
    item: Lee-Rangel HA
      type: Person
      first name: Héctor Aarón
      last name: Lee-Rangel
      member of: Facultad de Agronomía y Veterinaria, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
  slot:
    index: 7
    item: Amaya GD
      type: Person
      first name: Germán Danilo
      last name: Amaya
      member of: Department of School of Agriculture, Policy and Development, University of Reading, Reading, UK.
  slot:
    index: 8
    item: Keim JP
      type: Person
      first name: Juan Pablo
      last name: Keim
      member of: Faculty of Agricultural Sciences, Animal Production Institute, Universidad Austral de Chile, Valdivia, Chile.
  slot:
    index: 9
    item: Baudracco J
      type: Person
      first name: Javier
      last name: Baudracco
      member of: IciAgro Litoral, Universidad Nacional del Litoral-CONICET, Kreder 2805 Esperanza (3080), Argentina.
  slot:
    index: 10
    item: Mendonça Vieira RA
      type: Person
      first name: Ricardo Augusto
      last name: Mendonça Vieira
      member of: Laboratório de Zootecnia, Centro de Ciências e Tecnologias Agropecuárias (CCTA), Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ, Brazil.
  slot:
    index: 11
    item: Ghavipanje N
      type: Person
      first name: Navid
      last name: Ghavipanje
      member of: Faculty of Agriculture, Department of Animal Science, University of Birjand, Birjand, Iran.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 23
ending page: 32
has place of publication: England
source: Anim Front. 2024-12;14(6):23-32.
volume: 14

Artificial intelligence for livestock: a narrative review of the applications of computer vision systems and large language models for animal farming.
pmid: 39764529
has PII: vfae048
doi: 10.1093/af/vfae048
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Menezes GL
      type: Person
      first name: Guilherme L
      last name: Menezes
      member of: Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53703, USA.
  slot:
    index: 2
    item: Mazon G
      type: Person
      first name: Gustavo
      last name: Mazon
      member of: Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53703, USA.
  slot:
    index: 3
    item: Ferreira REP
      type: Person
      first name: Rafael E P
      last name: Ferreira
      member of: Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53703, USA.
  slot:
    index: 4
    item: Cabrera VE
      type: Person
      first name: Victor E
      last name: Cabrera
      member of: Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53703, USA.
  slot:
    index: 5
    item: Dorea JRR
      type: Person
      first name: Joao R R
      last name: Dorea
      member of: Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53703, USA.Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI 53703, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2160-6064
has issn l: 2160-6056
issue: 6
has NLM journal title abbreviation: Anim Front
publication name: Animal frontiers : the review magazine of animal agriculture
language: eng
has national library of medicine journal id: 101754918
derived from: NLM
starting page: 42
ending page: 53
has place of publication: England
source: Anim Front. 2024-12;14(6):42-53.
volume: 14

Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia.
pmid: 39764531
abstract: Historically, psychiatric diagnoses have been made based on patient's reported symptoms applying the criteria from diagnostic and statistical manual of mental disorders. The utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant goal. There have been several studies that examine brain imaging in psychiatric disorders, but more work is needed to elucidate the complexities of the human brain. In this editorial, we examine two articles by Xu et al and Stoyanov et al, that show developments in the direction of using neuroimaging to examine the brains of people with schizophrenia and depression. Xu et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia, in addition to examining neurotransmitter levels as biomarkers. Stoyanov et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and depression. These two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.96578
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Tirpack AK
      type: Person
      first name: Aidan K
      last name: Tirpack
      member of: Department of Psychiatry, Campbell University School of Osteopathic Medicine, Buies Creek, NC 27506, United States.
  slot:
    index: 2
    item: Buttar DG
      type: Person
      first name: Danyaal G
      last name: Buttar
      member of: Department of Psychiatry, Campbell University School of Osteopathic Medicine, Buies Creek, NC 27506, United States.
  slot:
    index: 3
    item: Kaur M
      type: Person
      first name: Mandeep
      last name: Kaur
      member of: Department of Psychiatry and Behavioral Health, Mercyhealth Hospital and Trauma Center, Janesville, WI 53548, United States. mandy.drmandeep@gmail.com.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 96578
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):96578.
volume: 13

Intricacies during pregnancy with gestational diabetes mellitus.
pmid: 39764532
abstract: The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus (GDM) development using advanced proteomic techniques, such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass spectrometry. Their analysis revealed 47 differentially expressed proteins in the GDM group, with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to controls. Although these findings are promising, the study is limited by its small sample size (n = 4 per group) and lacks essential details on the reproducibility and reliability of the protein quantification methods used. Furthermore, the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics analysis. The study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for GDM. Predicting GDM risk during the first trimester or pre-conceptional period may offer more clinical relevance. Despite its limitations, the study presents valuable insights into potential GDM biomarkers, but larger, well-validated studies are needed to establish their predictive utility and generalizability.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.93632
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Rattan R
      type: Person
      first name: Richa
      last name: Rattan
      member of: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
  slot:
    index: 2
    item: Pal R
      type: Person
      first name: Rimesh
      last name: Pal
      member of: Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
  slot:
    index: 3
    item: Gupta PC
      type: Person
      first name: Parul Chawla
      last name: Gupta
      member of: Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, Punjab, India.
  slot:
    index: 4
    item: Morya AK
      type: Person
      first name: Arvind Kumar
      last name: Morya
      member of: Department of Ophthalmology, All India Institute of Medical Sciences, Hyderabad 508126, Telangana, India. bulbul.morya@gmail.com.
  slot:
    index: 5
    item: Prasad R
      type: Person
      first name: Ripunjay
      last name: Prasad
      member of: Department of Ophthalmology, RP Eye Institute, Delhi 110001, India.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 93632
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):93632.
volume: 13

Searching for new drugs to treat Alzheimer's disease dementia through multiple pathways.
pmid: 39764533
abstract: Dementia is a group of diseases, including Alzheimer's disease (AD), vascular dementia, Lewy body dementia, frontotemporal dementia, Parkinson's disease dementia, metabolic dementia and toxic dementia. The treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms, nutritional support therapy for repairing nerve cells, psychological auxiliary treatment, and treatment that improves cognitive function through drugs. Among them, drug therapy to improve cognitive function is important. This review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function, especially the new progress in drug treatment for AD. We mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase, N-methyl-D-aspartate glutamate receptor, amyloid protein, tau protein and chronic immune inflammation.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.100833
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Bai H
      type: Person
      first name: Hua
      last name: Bai
      member of: Department of Neurology, The Third Affiliated Hospital of Guizhou Medical University, Duyun 558099, Guizhou Province, China.Department of Neurology, Wulong Branch of the People's Hospital Affiliated to Chongqing University, Wulong 408500, Chongqing, China. baih2020@gmc.edu.cn.
  slot:
    index: 2
    item: Feng XF
      type: Person
      first name: Xiao-Feng
      last name: Feng
      member of: Department of Neurology, Guizhou Medical University, Guiyang 550004, Guizhou Province, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 100833
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):100833.
volume: 13

Practice patterns among ophthalmic surgeons in treating concomitant oculoplastic conditions in preoperative period: A questionnaire-based study.
pmid: 39764534
abstract: Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure. Some oculoplastic conditions, like nasolacrimal duct obstruction, have been extensively studied, whereas others, like eyelid malposition and thyroid eye disease, have received minimal or no research.To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.A cross-sectional survey was disseminated among ophthalmologists all over India. The survey included questions related to pre-operative evaluation, anaesthetic and surgical techniques preferred, post-operative care, the use of adjunctive therapies, and patient follow-up patterns.A total of 180 ophthalmologists responded to the survey. Most practitioners (89%) felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised. The most common surgical techniques employed were lacrimal drainage procedures (Dacryocystorhinostomy) (63.3%), eyelid malposition repair (36.9%), and ptosis repair (58.7%). Post-operatively, 47.7 % of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries. Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.Approximately 50% of ophthalmologists handle prevalent oculoplastic issues themselves, seeking the expertise of an oculoplastic surgeon under particular conditions. Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery. Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.94284
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Panda BB
      type: Person
      first name: Bijnya Birajita
      last name: Panda
      member of: Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India. bigyan_panda@yahoo.co.in.
  slot:
    index: 2
    item: Mishra C
      type: Person
      first name: Chitaranjan
      last name: Mishra
      member of: Department of Vitreo-Retina, Trilochan Netralaya, Sambalpur 768004, India.
  slot:
    index: 3
    item: Nayak B
      type: Person
      first name: Bhagabat
      last name: Nayak
      member of: Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India.
  slot:
    index: 4
    item: Roy AK
      type: Person
      first name: Avik Kumar
      last name: Roy
      member of: Department of Glaucoma Services, LV Prasad Eye Institute, Bhubaneswar 751013, India.
  slot:
    index: 5
    item: Balakrishnan L
      type: Person
      first name: Logesh
      last name: Balakrishnan
      member of: Department of Statistics, Apollo Hospitals, Chennai 823104, India.
  slot:
    index: 6
    item: Mishra P
      type: Person
      first name: Priyadarshini
      last name: Mishra
      member of: Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 94284
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):94284.
volume: 13

Machine learning applications in healthcare clinical practice and research.
pmid: 39764535
abstract: Machine learning (ML) is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis, thus creating machines that can complete tasks otherwise requiring human intelligence. Among its various applications, it has proven groundbreaking in healthcare as well, both in clinical practice and research. In this editorial, we succinctly introduce ML applications and present a study, featured in the latest issue of the World Journal of Clinical Cases. The authors of this study conducted an analysis using both multiple linear regression (MLR) and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease (NAFLD). Their results implicated age as the most important determining factor in both groups, followed by lactic dehydrogenase, uric acid, forced expiratory volume in one second, and albumin. In addition, for the NAFLD- group, the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure, as compared to plasma calcium and body fat for the NAFLD+ group. However, the study's distinctive contribution lies in its adoption of ML methodologies, showcasing their superiority over traditional statistical approaches (herein MLR), thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.99744
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Arkoudis NA
      type: Person
      first name: Nikolaos-Achilleas
      last name: Arkoudis
      member of: Research Unit of Radiology and Medical Imaging, School of Medicine, National and Kapodistrian University of Athens, Athens 11528, Greece.2 Department of Radiology, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Chaidari 12462, Greece. nick.arkoudis@gmail.com.
  slot:
    index: 2
    item: Papadakos SP
      type: Person
      first name: Stavros P
      last name: Papadakos
      member of: Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 99744
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):99744.
volume: 13

Assessing healthcare workers' knowledge and confidence in the diagnosis, management and prevention of Monkeypox.
pmid: 39764536
abstract: Monkeypox (Mpox), is a disease of global public health concern, as it does not affect only countries in western and central Africa.To assess Burundi healthcare workers (HCWs)s' level of knowledge and confidence in the diagnosis and management of Mpox.We conducted a cross-sectional study via an online survey designed mainly from the World Health Organization course distributed among Burundi HCWs from June-July 2023. The questionnaire comprises 8 socioprofessional-related questions, 22 questions about Mpox disease knowledge, and 3 questions to assess confidence in Mpox diagnosis and management. The data were analyzed via SPSS software version 25.0. A P value < 0.05 was considered to indicate statistical significance.The study sample comprised 471 HCWs who were mainly medical doctors (63.9%) and nurses (30.1%). None of the 22 questions concerning Mpox knowledge had at least 50% correct responses. A very low number of HCWs (17.4%) knew that Mpox has a vaccine. The confidence level to diagnose (21.20%), treat (18.00%) or prevent (23.30%) Mpox was low among HCWs. The confidence level in the diagnosis of Mpox was associated with the HCWs' age (P value = 0.009), sex (P value < 0.001), work experience (P value = 0.002), and residence (P value < 0.001). The confidence level to treat Mpox was significantly associated with the HCWs' age (P value = 0.050), sex (P value < 0.001), education (P value = 0.033) and occupation (P value = 0.005). The confidence level to prevent Mpox was associated with the HCWs' education (P value < 0.001), work experience (P value = 0.002), residence (P value < 0.001) and type of work institution (P value = 0.003).This study revealed that HCWs have the lowest level of knowledge regarding Mpox and a lack of confidence in the ability to diagnose, treat or prevent it. There is an urgent need to organize continuing medical education programs on Mpox epidemiology and preparedness for Burundi HCWs. We encourage future researchers to assess potential hesitan[cell cut: 2054 characters, first 2000 kept]
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.99884
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Ntawuyamara E
      type: Person
      first name: Epipode
      last name: Ntawuyamara
      member of: Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital of Southern Medical University, Shenzhen 518101, Guangdong Province, China.Department of Dermatology and Venereology, Kamenge Teaching Hospital, University of Burundi, Bujumbura 1020, Burundi.
  slot:
    index: 2
    item: Ingabire T
      type: Person
      first name: Thierry
      last name: Ingabire
      member of: Department of Infectious Diseases, Kamenge Teaching Hospital, University of Burundi, Bujumbura 1020, Burundi.
  slot:
    index: 3
    item: Yandemye I
      type: Person
      first name: Innocent
      last name: Yandemye
      member of: General Directorate of Healthcare Supply, Modern and Traditional Medicine, Nutrition and Registration, Ministry of Public Health and Fight Against HIV/AIDS, Bujumbura 1055, Burundi.
  slot:
    index: 4
    item: Ndayikeza P
      type: Person
      first name: Polycarpe
      last name: Ndayikeza
      member of: Department of Epidemiology, National Institute of Public Health, Bujumbura 350, Burundi.General Directorate of Planification, Ministry of Public Health and Fight Against HIV/AIDS, Bujumbura 1055, Burundi.
  slot:
    index: 5
    item: Bhandari B
      type: Person
      first name: Bina
      last name: Bhandari
      member of: Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital of Southern Medical University, Shenzhen 518101, Guangdong Province, China.
  slot:
    index: 6
    item: Liang YH
      type: Person
      first name: Yan-Hua
      last name: Liang
      member of: Department of Dermatology, Cosmetology and Venereology, Shenzhen Hospital of Southern Medical University, Shenzhen 518101, Guangdong Province, China. liangdoctor@163.com.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 99884
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):99884.
volume: 13

New exploration on pathogenesis and early diagnosis of gestational diabetes.
pmid: 39764537
abstract: Gestational diabetes mellitus (GDM) refers to varying degrees of abnormal glucose metabolism that occur during pregnancy and excludes patients previously diagnosed with diabetes. GDM is a unique among the four subtypes of diabetes classified by the international World Health Organization standards. Although GDM patients constitute a small proportion of the total number of diabetes cases, the incidence of GDM has risen significantly over the past decade, posing substantial risk to pregnant women and infants. Therefore, it warrants considerable attention. The pathogenesis of GDM is generally considered to resemble that of type II diabetes, though it may have distinct characteristics. Analyzing blood biochemical proteins in the context of GDM can help elucidate its pathogenesis, thereby facilitating more effective prevention and management strategies. This article reviews this critical clinical issue to enhance the medical community's sufficient understanding of GDM.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.93826
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Bai H
      type: Person
      first name: Hua
      last name: Bai
      member of: Department of Neurology, The Third Affiliated Hospital of Guizhou Medical University, Duyun 558099, Guizhou Province, China. baih2020@gmc.edu.cn.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 93826
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):93826.
volume: 13

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy: A case report.
pmid: 39764538
abstract: Malignant transformation (MT) of mature cystic teratoma (MCT) has a poor prognosis, especially in advanced cases. Concurrent chemoradiotherapy (CCRT) has an inhibitory effect on MT.Herein, we present a case in which CCRT had a reduction effect preoperatively. A 73-year-old woman with pyelonephritis was referred to our hospital. Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass. Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) revealed squamous cell carcinoma. The patient was diagnosed with MT of MCT. Due to her poor general condition and renal malfunction, we selected CCRT, expecting fewer adverse effects. After CCRT, her performance status improved, and the tumor size was reduced; surgery was performed. Five months postoperatively, the patient developed dissemination and lymph node metastases. Palliative chemotherapy was ineffective. She died 18 months after treatment initiation.EUS-FNB was useful in the diagnosis of MT of MCT; CCRT suppressed the disease and improved quality of life.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.99938
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Kondo S
      type: Person
      first name: Saori
      last name: Kondo
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan. kondorabass@hotmail.co.jp.
  slot:
    index: 2
    item: Suzuki T
      type: Person
      first name: Takashi
      last name: Suzuki
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
  slot:
    index: 3
    item: Yoshiike K
      type: Person
      first name: Kanato
      last name: Yoshiike
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
  slot:
    index: 4
    item: Yamanaka S
      type: Person
      first name: Sakura
      last name: Yamanaka
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
  slot:
    index: 5
    item: Sonehara K
      type: Person
      first name: Kenta
      last name: Sonehara
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
  slot:
    index: 6
    item: Nabeshima H
      type: Person
      first name: Hiroshi
      last name: Nabeshima
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
  slot:
    index: 7
    item: Oguchi O
      type: Person
      first name: Osamu
      last name: Oguchi
      member of: Department of Obstetrics and Gynecology, Saku Central Hospital Advanced Care Center, Saku City 385-0051, Nagano, Japan.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 99938
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):99938.
volume: 13

Lipomatous ependymoma with ZFTA: RELA fusion-positive: A case report.
pmid: 39764539
abstract: Ependymoma with lipomatous differentiation is a rare type of ependymoma. The ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system tumors. ZFTA fusion-positive lipomatous ependymoma has not been reported to date.We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six minutes. Magnetic resonance imaging showed a round cystic shadow of approximately 1.9 cm × 1.5 cm × 1.9 cm under the right parieto-occipital cortex. Microscopic examination showed characteristic perivascular pseudorosettes and adipose differentiation in the cytoplasm. Immunohistochemical staining showed that the tumor cells were negative for cytokeratin, NeuN, Syn and p53, but positive for GFAP, vimentin and S-100 protein. Significant punctate intracytoplasmic EMA immunoreactivity was observed. The level of Ki-67 was about 5%. Genetic analysis revealed ZFTA: RELA fusion. A craniotomy with total excision of the tumor was performed. The follow-up time was 36 months, no evidence of disease recurrence was found in magnetic resonance imaging.Based on these findings, the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous differentiation. This case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation, which can help pathologists to make a definitive diagnosis of this tumor.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.99746
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zhao XY
      type: Person
      first name: Xiao-Yu
      last name: Zhao
      member of: China Medical University, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
  slot:
    index: 2
    item: Yu JH
      type: Person
      first name: Juan-Han
      last name: Yu
      member of: Department of Pathology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yujuanhan@foxmail.com.
  slot:
    index: 3
    item: Wang YH
      type: Person
      first name: Yi-Hua
      last name: Wang
      member of: China Medical University, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
  slot:
    index: 4
    item: Liu YX
      type: Person
      first name: Yi-Xin
      last name: Liu
      member of: China Medical University, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
  slot:
    index: 5
    item: Xu L
      type: Person
      first name: Lu
      last name: Xu
      member of: China Medical University, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
  slot:
    index: 6
    item: Fu L
      type: Person
      first name: Lin
      last name: Fu
      member of: Department of Pathology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
  slot:
    index: 7
    item: Yi N
      type: Person
      first name: Ning
      last name: Yi
      member of: Anshan Cancer Hospital, Anshan 114000, Liaoning Province, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 99746
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):99746.
volume: 13

Navigating medial patellotibial ligament reconstruction: Clinical perspectives and surgical strategies.
pmid: 39764540
abstract: The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when required. The medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the patella. Despite this, both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°. The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of flexion. The clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still controversial. This editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers' understanding of this technique, especially because reported clinical outcomes have remained sparse.
rights: ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
doi: 10.12998/wjcc.v13.i1.95046
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Zicaro JP
      type: Person
      first name: Juan Pablo
      last name: Zicaro
      member of: Division of Knee, Hospital Italiano de Buenos Aires, Buenos Aires 1109, Argentina.
  slot:
    index: 2
    item: Garcia-Mansilla I
      type: Person
      first name: Ignacio
      last name: Garcia-Mansilla
      member of: Division of Knee, Hospital Italiano de Buenos Aires, Buenos Aires 1109, Argentina. ignaciogmansilla@gmail.com.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T04:46
ISSN: 2307-8960
has issn l: 2307-8960
issue: 1
has NLM journal title abbreviation: World J Clin Cases
publication name: World journal of clinical cases
language: eng
has national library of medicine journal id: 101618806
derived from: NLM
pg: 95046
has place of publication: United States
source: World J Clin Cases. 2025-01-06;13(1):95046.
volume: 13

L-arginine in patients with spinocerebellar ataxia type 6: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
pmid: 39764542
abstract: Therapeutic advancements for the polyglutamine diseases, particularly spinocerebellar degeneration, are eagerly awaited. We evaluated the safety, tolerability, and therapeutic effects of L-arginine, which inhibits the conformational change and aggregation of polyglutamine proteins, in patients with spinocerebellar ataxia type 6 (SCA6).A multicenter, randomized, double-blind, placebo-controlled phase 2 trial (clinical trial ID: AJA030-002, registration number: jRCT2031200135) was performed on 40 genetically confirmed SCA6 patients enrolled between September 1, 2020, and September 30, 2021. The main inclusion criteria were as follows: SCA6 diagnosed by genetic testing, 20 years of age or older, Scale for the Assessment and Rating of Ataxia (SARA) walking score of at least one point, and SARA total score of at least 10 points, and ability to walk 10 m or more with or without an assistive device. The investigational drug was administered orally at 0.50 g/kg/day (L-arginine group: L-arginine 0.38 g/kg/day; placebo group: L-arginine 0.0 g/kg/day) for 48 weeks. Subjects who consented to participate were assigned a subject identification code, and were allocated 1:1 to the L-arginine or the placebo group, according to a predetermined allocation chart. The primary efficacy endpoint was change in total Scale for the Assessment and Rating of Ataxia (SARA) score from baseline to 48 weeks. The secondary endpoints were 1) SARA walking + standing score, 2) each of the eight SARA scales at 0, 4, 8, 16, 24, 32, 40, and 48 weeks, and 3) TUGT, BDI-II, CGI, PGI-I, and SF-8.Forty patients received the investigational drug, and 37 completed the study (L-arginine group: 18; placebo group: 19). The mean medication adherence rate was 97.2% in the l-arginine group. Regarding the primary endpoint, the difference between the L-arginine group and the placebo group was -1.52 (95% CI: -3.10 to 0.06, P = 0.0582). As the secondary endpoints, the change of SARA total score from baseline was greater [cell cut: 2829 characters, first 2000 kept]
rights: © 2024 The Author(s).
has PII: S2589-5370(24)00531-5
doi: 10.1016/j.eclinm.2024.102952
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Ishihara T
      type: Person
      first name: Tomohiko
      last name: Ishihara
      member of: Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.Advanced Treatment of Neurological Diseases Branch, Endowed Research Branch, Brain Research Institute, Niigata University, Niigata, Japan.
  slot:
    index: 2
    item: Tada M
      type: Person
      first name: Masayoshi
      last name: Tada
      member of: Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.Department of Neurology, Niigata City General Hospital, Niigata, Japan.
  slot:
    index: 3
    item: Kanemitsu Y
      type: Person
      first name: Yoshitomi
      last name: Kanemitsu
      member of: Clinical and Translational Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan.
  slot:
    index: 4
    item: Takahashi Y
      type: Person
      first name: Yuji
      last name: Takahashi
      member of: Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  slot:
    index: 5
    item: Ishikawa K
      type: Person
      first name: Kinya
      last name: Ishikawa
      member of: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
  slot:
    index: 6
    item: Ikenaka K
      type: Person
      first name: Kensuke
      last name: Ikenaka
      member of: Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
  slot:
    index: 7
    item: Hirano M
      type: Person
      first name: Makito
      last name: Hirano
      member of: Department of Neurology, Kindai University Faculty of Medicine, Osaka, Japan.
  slot:
    index: 8
    item: Yokota T
      type: Person
      first name: Takanori
      last name: Yokota
      member of: Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
  slot:
    index: 9
    item: Minakawa EN
      type: Person
      first name: Eiko N
      last name: Minakawa
      member of: Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
  slot:
    index: 10
    item: Saito K
      type: Person
      first name: Katsuhisa
      last name: Saito
      member of: Department of Medical Innovation, Osaka University Graduate School of Medicine, Suita, Japan.
  slot:
    index: 11
    item: Nagai Y
      type: Person
      first name: Yoshitaka
      last name: Nagai
      member of: Department of Neurology, Kindai University Faculty of Medicine, Osaka, Japan.Life Science Research Institute, Kindai University Faculty of Medicine, Osaka, Japan.Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
  slot:
    index: 12
    item: Onodera O
      type: Person
      first name: Osamu
      last name: Onodera
      member of: Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102952
has place of publication: England
source: EClinicalMedicine. 2024-12;78():102952.
volume: 78

A noninvasive urinary microRNA-based assay for the detection of pancreatic cancer from early to late stages: a case control study.
pmid: 39764541
abstract: Pancreatic cancer is highly aggressive and has a low survival rate primarily due to late-stage diagnosis and the lack of effective early detection methods. We introduce here a novel, noninvasive urinary extracellular vesicle miRNA-based assay for the detection of pancreatic cancer from early to late stages.From September 2019 to July 2023, Urine samples were collected from patients with pancreatic cancer (n = 153) from five distinct sites (Hokuto Hospital, Kawasaki Medical School Hospital, National Cancer Center Hospital, Kagoshima University Hospital, and Kumagaya General Hospital) and non-cancer participants (n = 309) from two separate sites (Hokuto Hospital and Omiya City Clinic). The main inclusion criteria included a diagnosis of pancreatic cancer based on pathological or imaging examination, while multiple primary cancers were excluded. Extracellular vesicles were enriched using a polymer-based precipitation method, and miRNAs were comprehensively analyzed by small RNA sequencing. A machine learning model for pancreatic cancer detection was developed using a training dataset (n = 315) consisting of 99 pancreatic cancer participants (of which 33 were early-stage [I/IIA]) and 216 non-cancer participants, and validated with a test dataset (n = 147) consisting of 54 pancreatic cancer participants (of which 9 were early-stage [I/IIA]) and 93 non-cancer participants.This method showed consistent performance, with areas under the receiver operating characteristic curves of 0.972 (95% confidence interval [CI], 0.928-0.996) and 0.963 (95% CI, 0.932-0.988) in the training and test sets, respectively. The sensitivities for pancreatic cancer detection were 93.9% (95% CI, 87.5%-97.3%) and 77.8% (95% CI, 64.9%-87.3%) overall and 97.0% (95% CI, 83.9%-99.8%) and 77.8% (95% CI, 44.2%-95.9%) for stage I/IIA pancreatic cancer, respectively. The specificities were 91.7% (95% CI, 87.1%-94.7%) and 95.7% (95% CI, 89.4%-98.5%), respectively. We also evaluated the sensitivity of CA19-[cell cut: 3260 characters, first 2000 kept]
rights: © 2024 The Authors.
has PII: S2589-5370(24)00515-7
doi: 10.1016/j.eclinm.2024.102936
creator: OrderedList
  length: 26
  slot:
    index: 1
    item: Baba S
      type: Person
      first name: Shogo
      last name: Baba
      member of: Department of Pathology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido, Japan.
  slot:
    index: 2
    item: Kawasaki T
      type: Person
      first name: Tadatoshi
      last name: Kawasaki
      member of: Department of Health Screenings, Hokuto Hospital, Obihiro, Hokkaido, Japan.
  slot:
    index: 3
    item: Hirano S
      type: Person
      first name: Satoshi
      last name: Hirano
      member of: Department of Gastroenterological Surgery II, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
  slot:
    index: 4
    item: Nakamura T
      type: Person
      first name: Toru
      last name: Nakamura
      member of: Department of Gastroenterological Surgery II, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
  slot:
    index: 5
    item: Asano T
      type: Person
      first name: Toshimichi
      last name: Asano
      member of: Department of Gastroenterological Surgery II, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
  slot:
    index: 6
    item: Okazaki R
      type: Person
      first name: Ryo
      last name: Okazaki
      member of: Department of Gastroenterological Surgery II, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
  slot:
    index: 7
    item: Yoshida K
      type: Person
      first name: Koji
      last name: Yoshida
      member of: Department of Gastroenterology and Hepatology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
  slot:
    index: 8
    item: Kawase T
      type: Person
      first name: Tomoya
      last name: Kawase
      member of: Department of Gastroenterology and Hepatology, Kawasaki Medical School, Kurashiki, Okayama, Japan.Department of Gastroenterology, Hokuto Hospital, Obihiro, Hokkaido, Japan.
  slot:
    index: 9
    item: Kurahara H
      type: Person
      first name: Hiroshi
      last name: Kurahara
      member of: Department of Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  slot:
    index: 10
    item: Oi H
      type: Person
      first name: Hideyuki
      last name: Oi
      member of: Department of Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  slot:
    index: 11
    item: Yokoyama M
      type: Person
      first name: Masaya
      last name: Yokoyama
      member of: Department of Surgery, Kumagaya General Hospital, Kumagaya, Saitama, Japan.Department of Surgery, Division of Transplant Surgery, Virginia Commonwealth University, Richmond, VA, USA.
  slot:
    index: 12
    item: Kita J
      type: Person
      first name: Junji
      last name: Kita
      member of: Department of Surgery, Kumagaya General Hospital, Kumagaya, Saitama, Japan.
  slot:
    index: 13
    item: Imura J
      type: Person
      first name: Johji
      last name: Imura
      member of: Department of Diagnostic Pathology, Kumagaya General Hospital, Kumagaya, Saitama, Japan.
  slot:
    index: 14
    item: Kinoshita K
      type: Person
      first name: Kazuya
      last name: Kinoshita
      member of: Department of Surgery, Kumagaya General Hospital, Kumagaya, Saitama, Japan.
  slot:
    index: 15
    item: Kondo S
      type: Person
      first name: Shunsuke
      last name: Kondo
      member of: Department of Experimental Therapeutics, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.Outpatient Treatment Center, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
  slot:
    index: 16
    item: Okada M
      type: Person
      first name: Mao
      last name: Okada
      member of: Department of Experimental Therapeutics, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
  slot:
    index: 17
    item: Satake T
      type: Person
      first name: Tomoyuki
      last name: Satake
      member of: Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
  slot:
    index: 18
    item: Igawa YS
      type: Person
      first name: Yukiko Shimoda
      last name: Igawa
      member of: Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
  slot:
    index: 19
    item: Yoshida T
      type: Person
      first name: Tatsuya
      last name: Yoshida
      member of: Department of Experimental Therapeutics, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
  slot:
    index: 20
    item: Yamaguchi H
      type: Person
      first name: Hiroki
      last name: Yamaguchi
      member of: Craif. Inc, Nagoya, Aichi, Japan.
  slot:
    index: 21
    item: Ando Y
      type: Person
      first name: Yoriko
      last name: Ando
      member of: Craif. Inc, Nagoya, Aichi, Japan.Institute of Innovation for Future Society, Nagoya University, Nagoya, Aichi, Japan.
  slot:
    index: 22
    item: Mizunuma M
      type: Person
      first name: Mika
      last name: Mizunuma
      member of: Craif. Inc, Nagoya, Aichi, Japan.
  slot:
    index: 23
    item: Ichikawa Y
      type: Person
      first name: Yuki
      last name: Ichikawa
      member of: Craif. Inc, Nagoya, Aichi, Japan.Institute of Innovation for Future Society, Nagoya University, Nagoya, Aichi, Japan.
  slot:
    index: 24
    item: Hida K
      type: Person
      first name: Kyoko
      last name: Hida
      member of: Vascular Biology and Molecular Pathology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
  slot:
    index: 25
    item: Nishihara H
      type: Person
      first name: Hiroshi
      last name: Nishihara
      member of: Center for Cancer Genomics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  slot:
    index: 26
    item: Kato Y
      type: Person
      first name: Yasutaka
      last name: Kato
      member of: Department of Pathology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido, Japan.Center for Cancer Genomics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
created: 2025-1-7T10:54
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102936
has place of publication: England
source: EClinicalMedicine. 2024-12;78():102936.
volume: 78

GLP-1 receptor agonists beyond diabetes management.
pmid: 39764543
has PII: S2589-5370(24)00600-X
doi: 10.1016/j.eclinm.2024.103021
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: eClinicalMedicine
      type: Person
      last name: eClinicalMedicine
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 103021
has place of publication: England
source: EClinicalMedicine. 2024-12;78():103021.
volume: 78

Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review.
pmid: 39764544
abstract: Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like peptide-1 receptor agonists use (GLP-1 RAs) and alcohol consumption.Electronic searches were conducted on Ovid Medline, EMBASE, PsycINFO, clintrials.gov, and ProQuest until the end of March 2024. An updated search was done on 7th of August 2024. The primary outcome was to explore the association between GLP-1 RAs use and change in alcohol consumption. Secondary outcomes included evaluating the impact of GLP-1 RAs on occurrences of alcohol-related events, healthcare utilisation, and the effect on functional magnetic resonance imaging (fMRI) cue reactivity. This study is registered with PROSPERO #CRD42024531982.Six studies totalling 88,190 participants were included with 38,740 (43.9%) receiving GLP-1 RA, but only 286 participated in randomised controlled trials. Pooled mean age was 49.6 years (SD = 10.5). RCT data did not show a reduction in alcohol consumption over 30 days after 24 weeks of treatment with exenatide versus placebo (heavy drinking days 6.0 [higher in control group], 95% CI -7.4 to 19.4, p = 0.37), a subgroup analysis found a positive effect in people with obesity (BMI >30 kg/m2), with significant reductions in brain reward centre cue reactivity on fMRI. In a secondary analysis of an RCT participants taking dulaglutide compared to placebo were 29% more likely to reduce alcohol intake (relative effect size 0.71, 95% CI 0.52-0.97, p = 0.04). Observational studies showed fewer alcohol-related healthcare events and a significant reduction in alcohol use with GLP-1 RAs treatment compared to DPP4-Dipeptidyl peptidase 4 use, no treatment and/or alcohol intake at baseline.There is little high-quality evidence demonstrating the effect of GLP-1 RAs on alcohol use. Subgroup analysis from two RCTs and supporting data from four obse[cell cut: 2413 characters, first 2000 kept]
rights: © 2024 The Authors.
has PII: S2589-5370(24)00499-1
doi: 10.1016/j.eclinm.2024.102920
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Subhani M
      type: Person
      first name: Mohsan
      last name: Subhani
      member of: Nottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK.NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2UH, UK.
  slot:
    index: 2
    item: Dhanda A
      type: Person
      first name: Ashwin
      last name: Dhanda
      member of: Faculty of Health, University of Plymouth, Plymouth PL4 8AA, UK.
  slot:
    index: 3
    item: King JA
      type: Person
      first name: James A
      last name: King
      member of: National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, UK.
  slot:
    index: 4
    item: Warren FC
      type: Person
      first name: Fiona C
      last name: Warren
      member of: Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QJ, UK.
  slot:
    index: 5
    item: Creanor S
      type: Person
      first name: Siobhan
      last name: Creanor
      member of: Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QJ, UK.
  slot:
    index: 6
    item: Davies MJ
      type: Person
      first name: Melanie J
      last name: Davies
      member of: NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust and the University of Leicester, UK.Diabetes Research Centre, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Leicester General Hospital, Leicester LE5 4PW, UK.
  slot:
    index: 7
    item: Eldeghaidy S
      type: Person
      first name: Sally
      last name: Eldeghaidy
      member of: Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2UH, UK.Division of Food, Nutrition & Dietetics, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK.
  slot:
    index: 8
    item: Bawden S
      type: Person
      first name: Stephen
      last name: Bawden
      member of: Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2UH, UK.
  slot:
    index: 9
    item: Gowland PA
      type: Person
      first name: Penny A
      last name: Gowland
      member of: Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2UH, UK.
  slot:
    index: 10
    item: Bataller R
      type: Person
      first name: Ramon
      last name: Bataller
      member of: Liver Unit, Hospital Clinic, Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  slot:
    index: 11
    item: Greenwood J
      type: Person
      first name: Justin
      last name: Greenwood
      member of: NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2UH, UK.
  slot:
    index: 12
    item: Kaar S
      type: Person
      first name: Stephen
      last name: Kaar
      member of: Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, M139WL, UK.
  slot:
    index: 13
    item: Bhala N
      type: Person
      first name: Neeraj
      last name: Bhala
      member of: Nottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK.NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2UH, UK.
  slot:
    index: 14
    item: Aithal GP
      type: Person
      first name: Guruprasad P
      last name: Aithal
      member of: Nottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK.NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2UH, UK.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102920
has place of publication: England
source: EClinicalMedicine. 2024-12;78():102920.
volume: 78

Electronic cigarette usage amongst high school students in South Africa: a mixed methods approach.
pmid: 39764547
abstract: The WHO has highlighted that: promotion of e-cigarettes has led to marked increases in e-cigarette use by children and adolescents. The long-term neuropsychiatric and psychological consequences of substance abuse in adolescence is well recognised. Limited data exists on the adolescent burden of vaping-related nicotine addiction and behavioural and/or psychological dependence to guide pharmacological or behavioural interventions to stop electronic cigarette usage.A self-administered brief electronic survey was provided to a large, sample of high school students from January to October 2023 in South Africa. Questions on vaping usage, initiation, reasons for continuation and indicators of physical and psychological dependence were asked. A mixed methods approach was used to obtain and analyse quantitative and qualitative responses.25,149 students from 52 South Africa schools completed the survey. 45.8% identify as female, 51.7% male, 0.3% transgender, 2.1% do not identify with a gender. Current vaping was reported by 16.83% (95% CI: 16.47-17.30), with 36.71% reporting ever using a vaping product (95% CI: 26.06-37.36). The odds of vaping increased by grade but not with increasing school affluence. 47% vaped within the first hour of waking suggesting high nicotine addiction. Vaping initiation reasons of: 'social influences' and 'curiosity', changed significantly to ongoing motivations of: 'enjoyment', 'managing mental distress' and 'addiction' to nicotine. Paired quantitative/qualitative responses regarding stress and dependence showed inconsistencies at the individual student level.Vaping in the schools surveyed was high and increased by grade but was not associated with school level affluence. Drivers for vaping initiation change significantly to persistence drivers with significant nicotine addiction. Adolescent perceptions (qualitative/quantitative) are frequently incongruent suggesting that mixed methods evaluations are required to understand individual level driver[cell cut: 2382 characters, first 2000 kept]
rights: © 2024 The Author(s).
has PII: S2589-5370(24)00549-2
doi: 10.1016/j.eclinm.2024.102970
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: van Zyl-Smit RN
      type: Person
      first name: Richard N
      last name: van Zyl-Smit
      member of: Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town and Groote Schuur Hospital, South Africa.
  slot:
    index: 2
    item: Filby S
      type: Person
      first name: Samantha
      last name: Filby
      member of: Research Unit on the Economics of Excisable Products, School of Economics, University of Cape Town, South Africa.
  slot:
    index: 3
    item: Soin G
      type: Person
      first name: Gurveen
      last name: Soin
      member of: Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town and Groote Schuur Hospital, South Africa.
  slot:
    index: 4
    item: Hoare J
      type: Person
      first name: Jacqueline
      last name: Hoare
      member of: Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town and Groote Schuur Hospital, South Africa.
  slot:
    index: 5
    item: van den Bosch A
      type: Person
      first name: Asya
      last name: van den Bosch
      member of: Utrecht University, Department of Interdisciplinary Social Science, Netherlands.
  slot:
    index: 6
    item: Kurten S
      type: Person
      first name: Sebastian
      last name: Kurten
      member of: Utrecht University, Department of Interdisciplinary Social Science, Netherlands.University of Cambridge, School of Clinical Medicine, England.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102970
has place of publication: England
source: EClinicalMedicine. 2024-12;78():102970.
volume: 78

HIV interventions across the care continuum for adolescents in high-burden countries: a systematic review and meta-analysis.
pmid: 39764546
abstract: Adolescents (10-19 years old) have poor outcomes across the prevention-to-treatment HIV care continuum, leading to significant mortality and morbidity. We conducted a systematic review and meta-analysis of interventions that documented HIV outcomes among adolescents in HIV high-burden countries.We searched PubMed, EMBASE, Scopus, and the Cochrane Library for studies published between January 2015 and September 2024, assessing at least one HIV outcome along the prevention-to-care cascade, including PrEP uptake, HIV testing, awareness of HIV infections, ARV adherence, retention, and virological suppression. We included studies from 37 HIV high-burden countries evaluating interventions with a comparator group. Random-effects meta-analysis was used to pool the effects of the interventions on study outcomes. While the primary focus was on outcomes related to the HIV care cascade, we also evaluated social outcomes and mental health outcomes when sufficient data were available. Adolescent engagement in studies was assessed using Hart's ladder. The study was registered in PROSPERO, CRD42024569203.We identified 12,411 unique records, of which 99 were included in the final analysis, comprising 57 randomized controlled trials and 42 non-randomized studies, with a total sample size of 441,252 participants. Our analysis found that asset-building interventions significantly improved HIV testing uptake (three studies, RR: 1.38, 95% CI 1.15-1.65) compared to control conditions. Differentiated service delivery interventions were associated with improved ART retention (five studies, RR: 1.18, 95% CI 1.04-1.36) and virological suppression (seven studies, RR: 1.19, 95% CI 1.06-1.33) compared to control conditions. Financial incentives significantly enhanced ART adherence (two studies, RR: 1.52, 95% CI 1.23-1.89) compared to control conditions. Digital interventions, such as mobile phone applications and telehealth services, significantly increased HIV testing uptake (two studies, RR: 1[cell cut: 3040 characters, first 2000 kept]
rights: © 2024 The Authors.
has PII: S2589-5370(24)00568-6
doi: 10.1016/j.eclinm.2024.102989
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Tao Y
      type: Person
      first name: Yusha
      last name: Tao
      member of: University of North Carolina Project-China, Guangzhou, China.Dermatology Hospital of South Medical University, Guangzhou, China.
  slot:
    index: 2
    item: Byrne M
      type: Person
      first name: Margaret
      last name: Byrne
      member of: Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, USA.
  slot:
    index: 3
    item: Ho D
      type: Person
      first name: Dorian
      last name: Ho
      member of: Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.
  slot:
    index: 4
    item: Zhu Z
      type: Person
      first name: Zixuan
      last name: Zhu
      member of: University of North Carolina Project-China, Guangzhou, China.Dermatology Hospital of South Medical University, Guangzhou, China.
  slot:
    index: 5
    item: Conklin JL
      type: Person
      first name: Jamie L
      last name: Conklin
      member of: Health Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  slot:
    index: 6
    item: Hlatshwako TG
      type: Person
      first name: Takhona G
      last name: Hlatshwako
      member of: Department of Social Policy and Intervention, University of Oxford, UK.
  slot:
    index: 7
    item: Zhang L
      type: Person
      first name: Liyuan
      last name: Zhang
      member of: University of North Carolina Project-China, Guangzhou, China.Dermatology Hospital of South Medical University, Guangzhou, China.
  slot:
    index: 8
    item: Aribodor OB
      type: Person
      first name: Ogechukwu Benedicta
      last name: Aribodor
      member of: Social Innovation in Health Initiative (SIHI), Nnamdi Azikiwe University, Awka, Nigeria.Department of Zoology, Nnamdi Azikiwe University, Awka, Nigeria.
  slot:
    index: 9
    item: Magista M
      type: Person
      first name: Malida
      last name: Magista
      member of: Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia.
  slot:
    index: 10
    item: Shan W
      type: Person
      first name: Wenjie
      last name: Shan
      member of: Department of International Clinic, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 11
    item: Onyeama UF
      type: Person
      first name: Ujunwa F
      last name: Onyeama
      member of: Department of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  slot:
    index: 12
    item: Anikamadu O
      type: Person
      first name: Onyekachukwu
      last name: Anikamadu
      member of: Brown School of Social Work, Washington University in St. Louis, St Louis, MO, United States.
  slot:
    index: 13
    item: Mutisya LM
      type: Person
      first name: Linet M
      last name: Mutisya
      member of: Maternal and Child Health Project, Swedish Organization for Global Health, Mayuge, Uganda.
  slot:
    index: 14
    item: Chima K
      type: Person
      first name: Kelechi
      last name: Chima
      member of: Nuffield Department of Medicine, University of Oxford, UK.
  slot:
    index: 15
    item: Mustapha A
      type: Person
      first name: Ashiru
      last name: Mustapha
      member of: Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
  slot:
    index: 16
    item: Paipilla KA
      type: Person
      first name: Kathleen Agudelo
      last name: Paipilla
      member of: Centro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia.
  slot:
    index: 17
    item: Omenugha I
      type: Person
      first name: Ijeoma
      last name: Omenugha
      member of: Barts and The London School of Medicine and Dentistry Queen Mary University of London, UK.
  slot:
    index: 18
    item: Magongo EN
      type: Person
      first name: Eleanor Namusoke
      last name: Magongo
      member of: Ministry of Health, Kampala, Uganda.
  slot:
    index: 19
    item: Lwelunmor J
      type: Person
      first name: Juliet
      last name: Lwelunmor
      member of: School of Medicine/Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
  slot:
    index: 20
    item: Vorkorper S
      type: Person
      first name: Susan
      last name: Vorkorper
      member of: Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
  slot:
    index: 21
    item: Sturke R
      type: Person
      first name: Rachel
      last name: Sturke
      member of: Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
  slot:
    index: 22
    item: Tang W
      type: Person
      first name: Weiming
      last name: Tang
      member of: University of North Carolina Project-China, Guangzhou, China.Dermatology Hospital of South Medical University, Guangzhou, China.Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, USA.
  slot:
    index: 23
    item: Walker D
      type: Person
      first name: Damilola
      last name: Walker
      member of: HIV/AIDS Section, Health Programmes, United Nations Children's Fund, New York, USA.
  slot:
    index: 24
    item: Tucker JD
      type: Person
      first name: Joseph D
      last name: Tucker
      member of: University of North Carolina Project-China, Guangzhou, China.Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, USA.Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 Dec
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102989
has place of publication: England
source: EClinicalMedicine. 2024-12;78():102989.
volume: 78

Contrast-enhanced ultrasound as a valuable tool to detect minimal inflammation in RA patients in sustained remission.
pmid: 39764550
abstract: The study aimed to explore the utility of contrast-enhanced ultrasound (CEUS) as a tool for detecting minimal inflammation in rheumatoid arthritis (RA) patients in sustained remission (SR) and to correlate the findings with Disease Activity Score 28 (DAS28) status scores and various ultrasound (US) scores.Thirty RA patients in SR (minimum 6 months), 12 with active disease, and 10 healthy controls were included. Clinical evaluations and US assessments were performed, including grayscale US (GSUS), power Doppler US (PDUS), and Global OMERACT-EULAR Synovitis Score (GLOESS). The CEUS was performed in the two most active joints and was scored semi-quantitatively (SQ) and quantitatively.Healthy controls and remission RA patients had similar total US scores. Active RA patients had higher US scores than the healthy and remission groups, with statistically significant differences in all the groups compared to the healthy group. However, significant differences were only observed in the GSUS and GLOESS when comparing active RA patients with the remission group. Ninety-five joints were selected for the CEUS, and we detected more microvascularization with the SQ CEUS score than with the PDUS in all groups (18 vs. 58% in the remission group; p-value 0.006). The weighted Cohen's kappa for the intra-rater and inter-rater IACUS CEUS score was 0.714 (confidence interval 0.610-0.819, p-value < 0.001) and 0.540 (confidence interval: 0.419-0.662, p-value < 0.001), respectively. Spearman's correlation between the SQ CEUS and quantitative scores was 0.655.For the majority of RA patients in SR, conventional US may fail to detect microvascularization potentially related to the subclinical disease. The CEUS may be helpful for this purpose.
rights: Copyright © 2024 Polido-Pereira, António, Khmelinskii, Arese, Teixeira, Vieira-Sousa, D'Agostino and Fonseca.
doi: 10.3389/fmed.2024.1459802
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Polido-Pereira J
      type: Person
      first name: Joaquim
      last name: Polido-Pereira
      member of: Rheumatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
  slot:
    index: 2
    item: António MS
      type: Person
      first name: Manuel S
      last name: António
      member of: Rheumatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
  slot:
    index: 3
    item: Khmelinskii N
      type: Person
      first name: Nikita
      last name: Khmelinskii
      member of: Rheumatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
  slot:
    index: 4
    item: Arese M
      type: Person
      first name: Marta
      last name: Arese
      member of: Universitá Cattolica del Sacro Cuore-Foundation Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  slot:
    index: 5
    item: Teixeira R
      type: Person
      first name: Rui
      last name: Teixeira
      member of: Rheumatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
  slot:
    index: 6
    item: Vieira-Sousa E
      type: Person
      first name: Elsa
      last name: Vieira-Sousa
      member of: Rheumatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
  slot:
    index: 7
    item: D'Agostino MA
      type: Person
      first name: Maria A
      last name: D'Agostino
      member of: Rheumatology Department Catholic University of Sacred Hearth, Foundation Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  slot:
    index: 8
    item: Fonseca JE
      type: Person
      first name: João E
      last name: Fonseca
      member of: Rheumatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1459802
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1459802.
volume: 11

Editorial: Tumor microenvironment and beyond: imaging systemic immunity with PET.
pmid: 39764551
doi: 10.3389/fmed.2024.1535802
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Levi J
      type: Person
      first name: Jelena
      last name: Levi
      member of: CellSight Technologies, Inc., San Francisco, CA, United States.
  slot:
    index: 2
    item: Alam IS
      type: Person
      first name: Israt S
      last name: Alam
      member of: Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
  slot:
    index: 3
    item: Nobashi TW
      type: Person
      first name: Tomomi W
      last name: Nobashi
      member of: Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, Kyoto, Japan.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1535802
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1535802.
volume: 11

Case report: Toxic epidermal necrolysis induced by tislelizumab in a patient with esophageal squamous cell carcinoma.
pmid: 39764552
abstract: Immune checkpoint inhibitors (ICIs) have been widely applicated for the treatment of patients with advanced esophageal cancer. Skin-related adverse reactions are frequent with ICIs, with toxic epidermal necrolysis (TEN) being a severe and potentially life-threatening cutaneous reaction.We present a case of a 70-year-old male with locally advanced esophageal cancer who developed severe toxic epidermal necrolysis (TEN) after 18 days of tislelizumab combined with chemotherapy. The condition rapidly progressed to cover approximately 90% of his body. After treatment with intravenous methylprednisolone, immunoglobulin, and antibiotics, along with active nutritional support and wound care, the patient recovered from TEN induced by tislelizumab.Treatment for TEN is complex, and no standardized guidelines currently exist. We propose an economical, safe, effective, and simple strategy for similar TEN patients.
rights: Copyright © 2024 Wu, Xu and Liu.
doi: 10.3389/fmed.2024.1522525
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wu S
      type: Person
      first name: Shilong
      last name: Wu
      member of: Department of Thoracic Surgery, Ganzhou People's Hospital, Ganzhou, China.
  slot:
    index: 2
    item: Xu C
      type: Person
      first name: Chenyang
      last name: Xu
      member of: Department of Thoracic Surgery, Ganzhou People's Hospital, Ganzhou, China.
  slot:
    index: 3
    item: Liu H
      type: Person
      first name: Huafeng
      last name: Liu
      member of: Department of Oncology, Ganzhou People's Hospital, Ganzhou, China.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1522525
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1522525.
volume: 11

Reduced portal vein blood flow velocity in acute fatty liver of pregnancy.
pmid: 39764553
abstract: Acute fatty liver of pregnancy (AFLP) is a severe complication that can occur in the third trimester or immediately postpartum, characterized by rapid hepatic failure. This study aims to explore the changes in portal vein blood flow velocity and liver function during pregnancy, which may assist in the early diagnosis and management of AFLP.This longitudinal study was conducted at a tertiary healthcare center with participants recruited from routine antenatal check-ups. The study included healthy women aged 20-40 years with singleton pregnancies. Doppler ultrasonography was used to assess portal vein flow and velocity, complemented by standard laboratory tests to monitor liver function. A nomogram model integrating the clinical features and Doppler ultrasonography parameters was constructed using logistic regression analysis for differentiating AFLP from normal controls.A total of 135 women were enrolled, divided into control and AFLP groups. The AFLP group demonstrated a significant reduction in portal vein flow velocity and alterations in liver dimensions. Laboratory tests indicated elevated liver enzymes and altered lipid profiles in the AFLP group. Statistical analysis showed that portal vein flow velocity could be a sensitive marker for predicting liver dysfunction in AFLP. The area under the receiver operating characteristic (ROC) curves (AUC) of the nomogram model were 0.88 (95% confidence interval [CI]: 0.82-0.95) with specificity, sensitivity, negative predictive value, and positive predictive value of 67.8, 95.0, 95.0, and 67.8, respectively, in the training cohort and 0.86 (95% CI: 0.72-0.98) and 86.9, 75.0, 83.3, and 80.0 in the test cohort, respectively. The calibration curves demonstrated good agreement between the predicted and observed probability for predicting AFLP.The study underscores the potential of using portal vein flow velocity as an early diagnostic marker for AFLP in pregnant women. Further research is required to establish standardized dia[cell cut: 2053 characters, first 2000 kept]
rights: Copyright © 2024 Zhao, Zhang, Li, Zhou, Jiang, Jia and Qin.
doi: 10.3389/fmed.2024.1506340
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zhao Y
      type: Person
      first name: Yang
      last name: Zhao
      member of: Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.
  slot:
    index: 2
    item: Zhang EK
      type: Person
      first name: Er-Ke
      last name: Zhang
      member of: Department of Medical Ultrasound, The Central Hospital of Karamay, Karamay, China.
  slot:
    index: 3
    item: Li DH
      type: Person
      first name: Dan-Hua
      last name: Li
      member of: Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.
  slot:
    index: 4
    item: Zhou YJ
      type: Person
      first name: Yu-Jing
      last name: Zhou
      member of: Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.
  slot:
    index: 5
    item: Jiang H
      type: Person
      first name: Hui
      last name: Jiang
      member of: Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.
  slot:
    index: 6
    item: Jia XC
      type: Person
      first name: Xiao-Chao
      last name: Jia
      member of: Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.
  slot:
    index: 7
    item: Qin C
      type: Person
      first name: Chuan
      last name: Qin
      member of: Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.Department of Medical Ultrasound, The Central Hospital of Karamay, Karamay, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1506340
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1506340.
volume: 11

Socioeconomic predictors of preventive health check-ups by a general practitioner in the Czech Republic.
pmid: 39764554
abstract: Health is one of the Sustainable Development Goals. The importance of health promotion is growing in the context of an aging population and increasing life expectancy. Prevention is often underestimated and neglected by citizens. This article aims to identify the socioeconomic predictors of preventive health check-ups by general practitioners in the Czech Republic, focusing on selected age groups. An original dataset is prepared based on data for 2010-2019 provided by the largest health insurance company in the Czech Republic, the General Health Insurance Company. Correlation and regression analysis methods are used to achieve the objectives. Two models are built and tested: (1) preventive examinations model and (2) preventive examinations in age group 65+ model. Based on the results, preventive medical examinations in the pensioner group depended on economic indicators, such as the average wage, employment, and gross domestic product, in the analyzed period. For the total population, overall population size, the average age, urbanized area, and level of education play a key role. The results reveal a difference between the general population group and the 65+ population group. Government interventions and health policies promoting prevention should consider using appropriate incentive policy instruments targeting the 65+ population to prolong active life in senior age.
rights: Copyright © 2024 Zimmermannova, Vevoda, Schovankova and Holy.
doi: 10.3389/fmed.2024.1341621
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zimmermannova J
      type: Person
      first name: Jarmila
      last name: Zimmermannova
      member of: Science and Research Centre, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czechia.
  slot:
    index: 2
    item: Vevoda J
      type: Person
      first name: Jiri
      last name: Vevoda
      member of: Department of Humanities and Social Sciences, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czechia.
  slot:
    index: 3
    item: Schovankova T
      type: Person
      first name: Tereza
      last name: Schovankova
      member of: Science and Research Centre, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czechia.
  slot:
    index: 4
    item: Holy O
      type: Person
      first name: Ondrej
      last name: Holy
      member of: Science and Research Centre, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czechia.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1341621
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1341621.
volume: 11

Predictors of response to bDMARDs and tsDMARDs in psoriatic arthritis: a pilot study on the role of musculoskeletal ultrasound.
pmid: 39764555
abstract: This pilot study aimed to identify early predictors of drug retention in patients with clinically active peripheral psoriatic arthritis who initiated or switched to therapy with biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs).Clinical and ultrasound assessments were conducted at baseline (t0) and subsequently at 1 (t1), 3 (t3), and 6 (t6) months. Ultrasound evaluations targeted joints/entheses according to PsASon-Score13 and the most clinically involved joint/enthesis/tendon or the two most clinically involved joints/entheses/tendons (MIJET and 2MIJET). After 6 months of follow-up, patients were divided into two groups based on drug retention, determined by the clinician's assessment of treatment efficacy (cResponder vs. non-cResponder). Main endpoints were ultrasound changes in MIJET, 2MIJET, and GUIS (Global US Inflammation Subscore) derived from PsASon-13.Twenty-nine patients were enrolled, 22 cResponders and 7 non-cResponders at t6. In the comparison between cResponders and non-cResponders, GUIS variation significantly differed in Δt6-t0, while MIJET and 2MIJET variations were significant as early as Δt3-t0 and confirmed in Δt6-t0. The ultrasound response of MIJET and 2MIJET was faster in cResponders treated with JAKi vs. those treated with TNFi and IL-17/12-23i, significant in Δt1-t0.Ultrasound imaging of clinically involved joint sites may be a valuable early predictor of therapy response for predicting drug retention at 6 months in patients with psoriatic arthritis.
rights: Copyright © 2024 Cozzi, Scagnellato, Lorenzin, Collesei, Oliviero, Damasco, Cosma, Basso, Doria and Ramonda.
doi: 10.3389/fmed.2024.1482894
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Cozzi G
      type: Person
      first name: Giacomo
      last name: Cozzi
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 2
    item: Scagnellato L
      type: Person
      first name: Laura
      last name: Scagnellato
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 3
    item: Lorenzin M
      type: Person
      first name: Mariagrazia
      last name: Lorenzin
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 4
    item: Collesei A
      type: Person
      first name: Antonio
      last name: Collesei
      member of: Cancer Genomics Core-Lab, Istituto Oncologico Veneto IRCCS, Padua, Italy.
  slot:
    index: 5
    item: Oliviero F
      type: Person
      first name: Francesca
      last name: Oliviero
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 6
    item: Damasco A
      type: Person
      first name: Amelia
      last name: Damasco
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 7
    item: Cosma C
      type: Person
      first name: Chiara
      last name: Cosma
      member of: Laboratory Medicine, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 8
    item: Basso D
      type: Person
      first name: Daniela
      last name: Basso
      member of: Laboratory Medicine, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 9
    item: Doria A
      type: Person
      first name: Andrea
      last name: Doria
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
  slot:
    index: 10
    item: Ramonda R
      type: Person
      first name: Roberta
      last name: Ramonda
      member of: Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padua, Italy.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1482894
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1482894.
volume: 11

Fungal keratitis caused by Neurospora: a case report.
pmid: 39764556
abstract: We report a rare case of fungal keratitis caused by Neurospora, a filamentous fungus that is widely distributed in soil and graminaceous plants.A 40-year-old Mongoloid male patient came to our outpatient clinic with painful swelling of the left eye and redness, after being cut by a tree branch 1 week prior. After examination, the patient was diagnosed with a corneal ulcer of the left eye, and was given levofloxacin eye drops and levofloxacin ophthalmic gel. However, the patient did not respond to the treatment. After admission to the hospital, fungal mycelium was found in the corneal smear. To further identify the pathogen, a corneal scraping culture was used to extract fungal DNA and PCR amplification was performed using ITS universal primers, which was later sequenced and identified as Neurospora. We used fluconazole injections (0.2 g/100 mL) as eye drops to treat the patient once every hour, and itraconazole (200 mg) was administered orally once a day. After a few days, the patient's condition improved.To the best of our knowledge, this is the first reported case of fungal keratitis caused by Neurospora in China. In this case, conventional topical and systemic treatment resulted in a favorable outcome. In patients with suspected fungal keratitis, medical treatment should be started urgently, and the treatment plan should be adjusted according to the subsequent experimental results and the patient's condition.
rights: Copyright © 2024 Lu, Mo, Weng and Li.
doi: 10.3389/fmed.2024.1496010
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lu Y
      type: Person
      first name: Yao
      last name: Lu
      member of: Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo First Hospital, Ningbo, China.
  slot:
    index: 2
    item: Mo Y
      type: Person
      first name: Yijun
      last name: Mo
      member of: Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo First Hospital, Ningbo, China.
  slot:
    index: 3
    item: Weng Y
      type: Person
      first name: Yuesong
      last name: Weng
      member of: Department of Clinical Laboratory, The Affiliated Peoples' Hospital of Ningbo University, Ningbo, Zhejiang, China.
  slot:
    index: 4
    item: Li X
      type: Person
      first name: Xiaohui
      last name: Li
      member of: Department of Ophthalmology, Ningbo Yinzhou No.2 Hospital, Ningbo Urology and Nephrology Hospital, Ningbo, Zhejiang, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024
dp: 2024
created: 2025-1-7T04:46
ISSN: 2296-858X
has issn l: 2296-858X
has NLM journal title abbreviation: Front Med (Lausanne)
publication name: Frontiers in medicine
language: eng
has national library of medicine journal id: 101648047
derived from: NLM
pg: 1496010
has place of publication: Switzerland
source: Front Med (Lausanne). 2024;11():1496010.
volume: 11

Targeting EZH1/2: tackling epigenetic resistance advances cancer therapy.
pmid: 39764558
has PII: MCO270022
doi: 10.1002/mco2.70022
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Zaki RA
      type: Person
      first name: Ram Abou
      last name: Zaki
      member of: Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute Melbourne Victoria Australia.Baker Department of Cardiometabolic Health The University of Melbourne Parkville Australia.
  slot:
    index: 2
    item: El-Osta A
      type: Person
      first name: Assam
      last name: El-Osta
      member of: Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute Melbourne Victoria Australia.Department of Medicine and Therapeutics The Chinese University of Hong Kong (CUHK) Hong Kong SAR China.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70022
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70022.
volume: 6

Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism.
pmid: 39764559
abstract: Therapies against hematological malignancies using chimeric antigen receptors (CAR)-T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer-specific solid tumor antigens. Therefore, the enrichment of tumor-antigen specific CAR-T cells in the desired region is critical for improving therapy efficacy and reducing systemic on-target/off-tumor side effects. Here, we functionalized human CAR-T cells with superparamagnetic iron oxide nanoparticles (SPIONs), making them magnetically controllable for site-directed targeting. SPION-loaded CAR-T cells maintained their specific cytolytic capacity against melanoma cells expressing the CAR-specific antigen chondroitin sulfate proteoglycan (CSPG4). Importantly, SPIONs suppressed cytokine release in the loaded CAR-T cells, shifting the cell death phenotype in the tumor cells from pyroptosis to apoptosis. Furthermore, SPION-loaded CAR-T cells could be enriched in a dynamic flow model through an external magnetic field and be detected in MRI. These results demonstrate that lytic cytotoxicity is retained after SPION-functionalization and provides a basis for future site-specific immunotherapies against solid tumors with reduced systemic adverse side effects.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270039
doi: 10.1002/mco2.70039
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Pfister F
      type: Person
      first name: Felix
      last name: Pfister
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.
  slot:
    index: 2
    item: Carnell LR
      type: Person
      first name: Lucas R
      last name: Carnell
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.
  slot:
    index: 3
    item: Löffler L
      type: Person
      first name: Lisa
      last name: Löffler
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.
  slot:
    index: 4
    item: Boosz P
      type: Person
      first name: Philipp
      last name: Boosz
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.
  slot:
    index: 5
    item: Schaft N
      type: Person
      first name: Niels
      last name: Schaft
      member of: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.Department of Dermatology Universitätsklinikum Erlangen Erlangen Germany.Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.Deutsches Zentrum Immuntherapie (DZI) Erlangen Germany.
  slot:
    index: 6
    item: Dörrie J
      type: Person
      first name: Jan
      last name: Dörrie
      member of: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.Department of Dermatology Universitätsklinikum Erlangen Erlangen Germany.Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.Deutsches Zentrum Immuntherapie (DZI) Erlangen Germany.
  slot:
    index: 7
    item: Stein R
      type: Person
      first name: René
      last name: Stein
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.
  slot:
    index: 8
    item: Lenz M
      type: Person
      first name: Malte
      last name: Lenz
      member of: Institute of Micro- and Nanostructure Research & Center for Nanoanalysis and Electron Microscopy Interdisciplinary Center for Nanostructured Films Friedrich-Alexander-University Erlangen Erlangen Germany.
  slot:
    index: 9
    item: Spiecker E
      type: Person
      first name: Erdmann
      last name: Spiecker
      member of: Institute of Micro- and Nanostructure Research & Center for Nanoanalysis and Electron Microscopy Interdisciplinary Center for Nanostructured Films Friedrich-Alexander-University Erlangen Erlangen Germany.
  slot:
    index: 10
    item: Huber CM
      type: Person
      first name: Christian M
      last name: Huber
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.Institute of Microwave and Photonics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.
  slot:
    index: 11
    item: Haddadin S
      type: Person
      first name: Sami
      last name: Haddadin
      member of: Chair of Robotics Science and Systems Intelligence Munich Institute of Robotics and Machine Intelligence (MIRMI), TUM School of Computation, Information and Technology Technical University of Munich Munich Germany.
  slot:
    index: 12
    item: Berking C
      type: Person
      first name: Carola
      last name: Berking
      member of: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.Department of Dermatology Universitätsklinikum Erlangen Erlangen Germany.Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.Deutsches Zentrum Immuntherapie (DZI) Erlangen Germany.
  slot:
    index: 13
    item: Alexiou C
      type: Person
      first name: Christoph
      last name: Alexiou
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.
  slot:
    index: 14
    item: Janko C
      type: Person
      first name: Christina
      last name: Janko
      member of: Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70039
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70039.
volume: 6

Prolyl 4-hydroxylase α-subunit family regulation of type I collagen deposition and IL17RB/c-Jun activation synergistically mediate choline dehydrogenase promotion of colorectal cancer metastasis.
pmid: 39764560
abstract: Metastasis continues to pose a significant challenge in tumor treatment. Evidence indicates that choline dehydrogenase (CHDH) is crucial in tumorigenesis. However, the functional role of CHDH in colorectal cancer (CRC) metastasis remains unreported. The study explored the functional role and mechanism of CHDH in CRC metastasis using human CRC tissues and a xenograft mouse model. CHDH expression was significantly higher in CRC compared to normal tissues and showed a positively correlation with CRC tumor-nodes-metastasis stage. CRC cell lines showed increased CHDH expression compared to normal controls. CHDH knockdown suppressed cell migration in vitro and tumor metastasis in vivo. Similarly, ectopic CHDH expression enhanced cell migration in vitro and tumor metastasis in vivo. Results suggested that CHDH affected the histone H3 trimethylation levels, which upregulated prolyl 4-hydroxylase α-subunit (P4HA) family gene (P4HA1/2/3) expression, further stabilizing collagen I expression and increasing IL17RB expression, which promoted downstream c-Jun activation. Together, P4HA and IL17RB promote CRC cell metastasis. P4HA and c-Jun inhibitors abolished CHDH-mediated CRC cell metastasis in vitro and in vivo. Collectively, the above findings provide novel evidence that that CHDH mediates CRC cell metastasis and may be a promising target for metastatic CRC therapy.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270007
doi: 10.1002/mco2.70007
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Yang X
      type: Person
      first name: Xiaowen
      last name: Yang
      member of: Cheeloo College of Medicine Shandong University Jinan China.Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 2
    item: Li Y
      type: Person
      first name: Yifei
      last name: Li
      member of: Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 3
    item: Shen X
      type: Person
      first name: Xinzhuang
      last name: Shen
      member of: Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 4
    item: Wang S
      type: Person
      first name: Shuying
      last name: Wang
      member of: Department of Oncology and Southwest Cancer Center Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
  slot:
    index: 5
    item: Zhang Z
      type: Person
      first name: Zhuqing
      last name: Zhang
      member of: Department of Oncology The Seventh Medical Center of Chinese PLA General Hospital Beijing China.
  slot:
    index: 6
    item: Du W
      type: Person
      first name: Wenfei
      last name: Du
      member of: Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 7
    item: Yang C
      type: Person
      first name: Chenglong
      last name: Yang
      member of: Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 8
    item: Jiang X
      type: Person
      first name: Xinyu
      last name: Jiang
      member of: Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 9
    item: Zhang X
      type: Person
      first name: Xiaoyuan
      last name: Zhang
      member of: Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
  slot:
    index: 10
    item: Huang Y
      type: Person
      first name: Yongming
      last name: Huang
      member of: Department of General Surgery Affiliated Hospital of Jining Medical University, Jining Medical University Jining China.
  slot:
    index: 11
    item: Shen W
      type: Person
      first name: Wenzhi
      last name: Shen
      member of: Cheeloo College of Medicine Shandong University Jinan China.Shandong Provincial Precision Medicine Laboratory for Chronic Non-communicable Diseases, Institute of Precision Medicine Jining Medical University Jining China.
created: 2025-1-7T06:21
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70007
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70007.
volume: 6

Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
pmid: 39764561
abstract: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is primarily known for causing severe joint and muscle symptoms, but its pathological effects have extended beyond these tissues. In this study, we conducted a comprehensive proteomic analysis across various organs in rodent and nonhuman primate models to investigate CHIKV's impact on organs beyond joints and muscles and to identify key host factors involved in its pathogenesis. Our findings reveal significant species-specific similarities and differences in immune responses and metabolic regulation, with proteins like Interferon-Stimulated Gene 15 (ISG15) and Retinoic Acid-Inducible Gene I (RIG-I) playing crucial roles in the anti-CHIKV defense. We observed upregulated and downregulated metabolic status in CHIKV-infected rhesus monkeys and mice, respectively. Additionally, we identified host factors such as S100 Calcium-Binding Protein A8/A9 (S100A8/A9), Voltage-Dependent Anion Channel 1/2 (VDAC1/2), Complement Component 3 (C3), Apoptosis-Inducing Factor Mitochondria-Associated 1 (AIFM1), Endothelial Cell-Specific Chemotaxis Regulator (ECSCR), and Kininogen 1 (KNG1) that may contribute to CHIKV-induced inflammation and hemorrhage. These insights put emphases on the importance of understanding CHIKV's impact on organs beyond joints and muscles, providing potential therapeutic targets and enhancing our understanding of CHIKV pathogenesis. This research underscores the need for appropriate animal models in CHIKV studies and informs the development of targeted therapies to address its systemic effects.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270013
doi: 10.1002/mco2.70013
creator: OrderedList
  length: 18
  slot:
    index: 1
    item: Lin D
      type: Person
      first name: Dongdong
      last name: Lin
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 2
    item: Tang C
      type: Person
      first name: Cong
      last name: Tang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 3
    item: Wang J
      type: Person
      first name: Junbin
      last name: Wang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 4
    item: Yang Y
      type: Person
      first name: Yun
      last name: Yang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 5
    item: Yang H
      type: Person
      first name: Hao
      last name: Yang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 6
    item: Zhou Y
      type: Person
      first name: Yanan
      last name: Zhou
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 7
    item: Yu W
      type: Person
      first name: Wenhai
      last name: Yu
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 8
    item: Li B
      type: Person
      first name: Bai
      last name: Li
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 9
    item: Huang Q
      type: Person
      first name: Qing
      last name: Huang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 10
    item: Wang H
      type: Person
      first name: Haixuan
      last name: Wang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 11
    item: An R
      type: Person
      first name: Ran
      last name: An
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 12
    item: Liang X
      type: Person
      first name: Xiaoming
      last name: Liang
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 13
    item: Yan Y
      type: Person
      first name: Yuhuan
      last name: Yan
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 14
    item: Yuan L
      type: Person
      first name: Longhai
      last name: Yuan
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 15
    item: Du X
      type: Person
      first name: Xuena
      last name: Du
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 16
    item: Yuan Y
      type: Person
      first name: Yuxia
      last name: Yuan
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 17
    item: Li Y
      type: Person
      first name: Yanwen
      last name: Li
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.
  slot:
    index: 18
    item: Lu S
      type: Person
      first name: Shuaiyao
      last name: Lu
      member of: Yunnan Key Laboratory of Cross-Border Infectious Disease Prevention and New Drug Development Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College) Ministry of Education Beijing China.State Key Laboratory of Respiratory Health and Multimorbidity Beijing China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70013
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70013.
volume: 6

PDPN+ cancer-associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF-κB activation and the CCL2-ACKR1 axis.
pmid: 39764562
abstract: Cancer-associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis of gastric tumor grade and stage, we identified a subset of proangiogenic CAFs characterized by high podoplanin (PDPN) expression, which are significantly enriched in metastatic lesions and secrete chemokine (CC-motif) ligand 2 (CCL2). Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF-κB signaling pathway. The canonical NF-κB signaling protein P65 binds to the promoter region of CCL2, inducing its expression. Additionally, we found that CCL2 interacts with its nonclassical receptor ACKR1 (expressed on endothelial cells) to exert its proangiogenic effects. Furthermore, the disruption of CCL2-ACKR1 communication via a CCL2 neutralizing antibody or the inhibition of AKT signaling transduction using AKT inhibitors effectively suppressed tumor growth. Together, this study elucidates the mechanism by which PDPN(+) CAFs promote angiogenesis, providing a deeper understanding of the molecular processes underlying CAF-mediated angiogenesis and suggesting potential therapeutic targets for gastric cancer treatment.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270037
doi: 10.1002/mco2.70037
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Zhao Z
      type: Person
      first name: Zhenxiong
      last name: Zhao
      member of: Department of Gastric Surgery Fudan University Shanghai Cancer Center Shanghai China.Department of Oncology Shanghai Medical College, Fudan University Shanghai China.
  slot:
    index: 2
    item: Sun H
      type: Person
      first name: Hui
      last name: Sun
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 3
    item: Liu Y
      type: Person
      first name: Yingxue
      last name: Liu
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 4
    item: Zhang Y
      type: Person
      first name: Yanqiu
      last name: Zhang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Endoscopy Fudan University Shanghai Cancer Center Shanghai China.
  slot:
    index: 5
    item: Wang X
      type: Person
      first name: Xin
      last name: Wang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 6
    item: Wang X
      type: Person
      first name: Xu
      last name: Wang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 7
    item: Tan C
      type: Person
      first name: Cong
      last name: Tan
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 8
    item: Ni S
      type: Person
      first name: Shujuan
      last name: Ni
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 9
    item: Weng W
      type: Person
      first name: Weiwei
      last name: Weng
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 10
    item: Zhang M
      type: Person
      first name: Meng
      last name: Zhang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 11
    item: Wang L
      type: Person
      first name: Lei
      last name: Wang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 12
    item: Huang D
      type: Person
      first name: Dan
      last name: Huang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 13
    item: Gu W
      type: Person
      first name: Wenchao
      last name: Gu
      member of: Department of Artificial Intelligence Medicine, Graduate School of Medicine Chiba University Chiba Japan.
  slot:
    index: 14
    item: Chang J
      type: Person
      first name: Jinjia
      last name: Chang
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Medical Oncology Fudan University Shanghai Cancer Center Shanghai China.
  slot:
    index: 15
    item: Sheng W
      type: Person
      first name: Weiqi
      last name: Sheng
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
  slot:
    index: 16
    item: Xu MD
      type: Person
      first name: Mi-Die
      last name: Xu
      member of: Department of Oncology Shanghai Medical College, Fudan University Shanghai China.Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.Institute of Pathology Fudan University Shanghai China.
created: 2025-1-7T10:54
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70037
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70037.
volume: 6

Osteoarthritis synovium as a nidus for monosodium urate crystal deposition inducing severe gout studied by label-free stimulated Raman scattering combined with synovial organoids.
pmid: 39764563
abstract: Gout, a common chronic disease, is characterized by the formation and deposition of monosodium urate (MSU) crystal deposition in articular and nonarticular structures. Osteoarthritis (OA), the most prevalent type of arthritis, is a progressive degenerative joint disease. Previous clinical studies have reported that gout frequently affects OA joints; however, the underlying mechanism remains unidentified. Recently, OA synovium has been proposed as a favorable vehicle for MSU crystal deposition. Therefore, this study aimed to investigate whether OA synovium acts as a nidus for MSU crystal deposition inducing severe gout flares, using label-free, highly-specific stimulated Raman scattering (SRS) microscopy combined with innovative preclinical models-synovial organoids. Crystal deposition, cellular phagocytosis, and subsequent inflammation intensity was imaged in ex vivo synovial organoids using SRS microscopy and other biochemical techniques. Results revealed that MSU crystals were more likely to deposit in OA synovium than in normal synovium. Furthermore, OA synoviocytes were more capable of phagocytosing crystals, leading to severe inflammation, and thus, expediting gout. These findings offer a potential explanation for why gout is preferred in OA joints and offer significant insights into the pathophysiology of gout, thereby informing prevention and management strategies for OA to prevent or alleviate the subsequent progression of gout.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270040
doi: 10.1002/mco2.70040
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Chen Z
      type: Person
      first name: Ziyi
      last name: Chen
      member of: Department of Sports Medicine Huashan Hospital Fudan University Shanghai China.
  slot:
    index: 2
    item: Wang W
      type: Person
      first name: Wenjuan
      last name: Wang
      member of: Department of Sports Medicine Huashan Hospital Fudan University Shanghai China.
  slot:
    index: 3
    item: Chen Y
      type: Person
      first name: Yaxin
      last name: Chen
      member of: State Key Laboratory of Surface Physics and Department of Physics Human Phenome Institute Multiscale Research Institute of Complex Systems Academy for Engineering and Technology Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education) Fudan University Shanghai China.
  slot:
    index: 4
    item: Ji M
      type: Person
      first name: Minbiao
      last name: Ji
      member of: State Key Laboratory of Surface Physics and Department of Physics Human Phenome Institute Multiscale Research Institute of Complex Systems Academy for Engineering and Technology Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education) Fudan University Shanghai China.
  slot:
    index: 5
    item: Hu Y
      type: Person
      first name: Yinghui
      last name: Hu
      member of: Department of Sports Medicine Huashan Hospital Fudan University Shanghai China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70040
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70040.
volume: 6

Altered zygotic gene expression caused by sperm with Tdrd6 variants disrupts early embryonic development.
pmid: 39764564
abstract: The precise mechanisms behind early embryonic arrest due to sperm-related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked to novel TDRD6 variants, associated with oligoasthenoteratozoospermia (OAT) and early embryonic arrest. To investigate the underlying mechanisms and promising therapeutic approaches, Tdrd6 knock-in and knock-out mice were generated. The Tdrd6 variant male mice demonstrated OAT and embryonic arrest, mirroring the clinical observations of our patients. Sperm from both affected individuals and mice exhibited aberrant localization of phospholipase C zeta and oocyte activation deficiency (OAD). The application of artificial oocyte activation (AOA) effectively overcame the infertility caused by the variants, facilitating successful pregnancies and live births in both human and mice. Additionally, our research revealed that OAD influences the expression of multitude of genes at the 2-pronuclear (2PN) stage, with the Mos gene playing a pivotal role in early embryonic arrest. The injection of Mos mRNA can mitigate this arrest. To our knowledge, this is the first study to show that sperm-related OAD affects gene expression at the 2PN stage and elucidate how AOA overcomes male factor-derived embryonic arrest, enabling successful pregnancies and live births.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270038
doi: 10.1002/mco2.70038
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Hu Z
      type: Person
      first name: Zhijie
      last name: Hu
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 2
    item: Zhang Y
      type: Person
      first name: Yuqi
      last name: Zhang
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 3
    item: Cai R
      type: Person
      first name: Renfei
      last name: Cai
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 4
    item: Chen Q
      type: Person
      first name: Qiuju
      last name: Chen
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 5
    item: Guo H
      type: Person
      first name: Haiyan
      last name: Guo
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 6
    item: Li D
      type: Person
      first name: Danjun
      last name: Li
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 7
    item: Lin W
      type: Person
      first name: Weidong
      last name: Lin
      member of: Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 8
    item: He H
      type: Person
      first name: Hongxi
      last name: He
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 9
    item: Wu H
      type: Person
      first name: Haibo
      last name: Wu
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 10
    item: Liu Y
      type: Person
      first name: Yali
      last name: Liu
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 11
    item: Li B
      type: Person
      first name: Bin
      last name: Li
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 12
    item: Xi Q
      type: Person
      first name: Qianwen
      last name: Xi
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 13
    item: Gao H
      type: Person
      first name: Hongyuan
      last name: Gao
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 14
    item: Zhang J
      type: Person
      first name: Jian
      last name: Zhang
      member of: Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 15
    item: Lyu Q
      type: Person
      first name: Qifeng
      last name: Lyu
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 16
    item: Kuang Y
      type: Person
      first name: Yanping
      last name: Kuang
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
  slot:
    index: 17
    item: Lu X
      type: Person
      first name: Xuefeng
      last name: Lu
      member of: Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70038
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70038.
volume: 6

http://rdf.ncbi.nlm.nih.gov/pubmed/39764567
pmid: 39764567
abstract: Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in major depressive disorder (MDD). However, the long-term effects of PT have never been compared with gold-standard treatments for MDD such as pharmacotherapy or psychotherapy alone or in combination.This is a 6-month follow-up study of a phase 2, double-blind, randomised, controlled trial involving patients with moderate-to-severe MDD. Participants were recruited from a hospital in the UK. Male or female patients with major depressive disorder (DSM-IV), moderate to severe depression (HAM-D ≥17), no MRI or SSRI contraindications, confirmed diagnosis by a GP or mental healthcare professional, aged 18-80, and competent in English were eligible. Patients were randomly assigned (1:1) to receive either two 25 mg doses of the psychedelic drug psilocybin administered orally combined with psychological support ('psilocybin therapy' or PT) and book-ended by further support or a 6-week course of the selective serotonin reuptake inhibitor (SSRI) escitalopram (administered daily at 10 mg for three weeks and 20 mg for the subsequent three weeks) plus matched psychological support ('escitalopram treatment' or ET). The primary outcome measure was change from baseline in the score on the 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR-16) at week 6, which has been reported previously. Herein, we present results at the 6-month follow-up time point. Measures of social functioning, connectedness, and meaning in life constituted the study's secondary outcomes during follow-up. Safety in the follow-up period was not assessed. This trial is registered at ClinicalTrials.gov, NCT03429075.Between January 15th, 2019 and March 20th, 2020, 59 patients were enrolled and 30 (11 females [37%] and 19 males [63%]) were assigned to the psilocybin group and 29 (9 females [31%] and 20 males [69%]) to the escitalopram group. 25 participants in the PT group and 21 in the ET group completed the 6-month[cell cut: 3487 characters, first 2000 kept]
rights: © 2024 The Authors.
has PII: S2589-5370(24)00378-X
doi: 10.1016/j.eclinm.2024.102799
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Erritzoe D
      type: Person
      first name: David
      last name: Erritzoe
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 2
    item: Barba T
      type: Person
      first name: Tommaso
      last name: Barba
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 3
    item: Greenway KT
      type: Person
      first name: Kyle T
      last name: Greenway
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
  slot:
    index: 4
    item: Murphy R
      type: Person
      first name: Roberta
      last name: Murphy
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 5
    item: Martell J
      type: Person
      first name: Jonny
      last name: Martell
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 6
    item: Giribaldi B
      type: Person
      first name: Bruna
      last name: Giribaldi
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 7
    item: Timmermann C
      type: Person
      first name: Christopher
      last name: Timmermann
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 8
    item: Murphy-Beiner A
      type: Person
      first name: Ashleigh
      last name: Murphy-Beiner
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 9
    item: Jones MB
      type: Person
      first name: Michelle Baker
      last name: Jones
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 10
    item: Nutt D
      type: Person
      first name: David
      last name: Nutt
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.
  slot:
    index: 11
    item: Weiss B
      type: Person
      first name: Brandon
      last name: Weiss
      member of: Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioural Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  slot:
    index: 12
    item: Carhart-Harris R
      type: Person
      first name: Robin
      last name: Carhart-Harris
      member of: Centre for Psychedelic Research, Division of Psychiatry, Department Brain Sciences, Imperial College London, United Kingdom.Departments of Neurology and Psychiatry, University of California San Francisco.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-10
dp: 2024 Oct
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102799
has place of publication: England
source: EClinicalMedicine. 2024-10;76():102799.
title: Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial.
volume: 76

RNA N4-acetylcytidine modification and its role in health and diseases.
pmid: 39764566
abstract: N4-acetylcytidine (ac4C) modification is a crucial RNA modification widely present in eukaryotic RNA. Previous studies have demonstrated that ac4C plays a pivotal role in viral infections. Despite numerous studies highlighting the strong correlation between ac4C modification and cancer progression, its detailed roles and molecular mechanisms in normal physiological processes and cancer progression remain incompletely understood. This review first outlines the key regulatory enzyme mediating ac4C modification, N-acetyltransferase 10 (NAT10), including its critical roles in regulating RNA stability, transcriptional efficiency, and translational fidelity. Additionally, it systematically summarizes the essential functions and mechanisms of ac4C modification in normal biological processes, including stem cell fate determination, spermatogenesis and oogenesis, embryonic development, cellular senescence, and bone remodeling. Furthermore, this review delves into the central roles and molecular mechanisms of ac4C modification in regulating malignant proliferation, cell cycle arrest, EMT, drug resistance, cell death, cancer metabolism, and tumor immunotherapy. It also emphasizes the potential of NAT10 as a prognostic biomarker and its therapeutic potential as a target for disease treatment. In summary, this review clarifies the multifaceted roles of ac4C modification in both health and disease and explores NAT10-targeted therapies with the aim of advancing cancer research and improving patient outcomes.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270015
doi: 10.1002/mco2.70015
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Wang Q
      type: Person
      first name: Qiang
      last name: Wang
      member of: Gastrointestinal Surgical Unit Suining Central Hospital Suining Sichuan China.
  slot:
    index: 2
    item: Yuan Y
      type: Person
      first name: Yixiao
      last name: Yuan
      member of: Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China.
  slot:
    index: 3
    item: Zhou Q
      type: Person
      first name: Qiang
      last name: Zhou
      member of: Department of Oncology Suining Central Hospital Suining Sichuan China.
  slot:
    index: 4
    item: Jia Y
      type: Person
      first name: YingDong
      last name: Jia
      member of: Gastrointestinal Surgical Unit Suining Central Hospital Suining Sichuan China.
  slot:
    index: 5
    item: Liu J
      type: Person
      first name: Jing
      last name: Liu
      member of: Gastrointestinal Surgical Unit Suining Central Hospital Suining Sichuan China.
  slot:
    index: 6
    item: Xiao G
      type: Person
      first name: GuangJun
      last name: Xiao
      member of: Department of Clinical Laboratory Medicine Suining Central Hospital Suining Sichuan China.
  slot:
    index: 7
    item: Li C
      type: Person
      first name: Chunhong
      last name: Li
      member of: Department of Oncology Suining Central Hospital Suining Sichuan China.
  slot:
    index: 8
    item: Jiang X
      type: Person
      first name: Xiulin
      last name: Jiang
      member of: Department of Medicine UF Health Cancer Center University of Florida Gainesville Florida USA.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70015
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70015.
volume: 6

In search of stories: narrative-aesthetic interventions to hear cancer patients' voices.
pmid: 39764568
has PII: S2589-5370(24)00371-7
doi: 10.1016/j.eclinm.2024.102792
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: van Laarhoven HWM
      type: Person
      first name: Hanneke W M
      last name: van Laarhoven
      member of: Amsterdam UMC Location University of Amsterdam, Medical Oncology, Amsterdam, the Netherlands.Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
  slot:
    index: 2
    item: van Poecke N
      type: Person
      first name: Niels
      last name: van Poecke
      member of: Amsterdam UMC Location University of Amsterdam, Medical Oncology, Amsterdam, the Netherlands.Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, the Netherlands.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-10
dp: 2024 Oct
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102792
has place of publication: England
source: EClinicalMedicine. 2024-10;76():102792.
volume: 76

Breast cancer-the impact of conflict and displacement.
pmid: 39764570
has PII: S2589-5370(24)00485-1
doi: 10.1016/j.eclinm.2024.102906
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: eClinicalMedicine
      type: Person
      last name: eClinicalMedicine
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-10
dp: 2024 Oct
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102906
has place of publication: England
source: EClinicalMedicine. 2024-10;76():102906.
volume: 76

Frequently asked questions on surrogate endpoints in oncology-opportunities, pitfalls, and the way forward.
pmid: 39764569
abstract: Patients with cancer expect prolonged life (overall survival, OS) or better life (quality of life, QOL) from cancer treatments. However, majority of new cancer drugs are now being approved not based on improved OS or QOL, but based on surrogate endpoints such as tumor shrinkage or delayed tumor progression. These surrogate endpoints, including their validity as a proxy for overall survival, differ based on disease settings and lines of treatment but in general, most surrogate measures have weak correlation with outcomes that matter to patients. Nevertheless, they are being increasingly used as the basis for regulatory decisions. The current tension in this space is between adoption of surrogate endpoints for early access to cancer drugs versus the need for confirmation that the drugs improve outcomes that matter and not merely improve scan results or surrogate endpoints. In this article, we provide a comprehensive review of surrogate endpoints currently used in oncology trials both in curative and advanced disease settings, including their definition, methodology for validation, existing evidence for their surrogacy, predictive versus prognostic reliability of surrogate endpoints, the promise of surrogate endpoints, their pitfalls, and the way forward. Using a Q&A format, we discuss answers to the most commonly asked questions regarding surrogate endpoints in oncology. Our review answers the following frequently asked questions about surrogate endpoints in oncology: how are surrogate endpoints defined? How are they validated? What is a patient-level versus trial-level surrogate? What are the benefits of using surrogate endpoints? What level of surrogacy is required for regular versus accelerated approval? Are we overusing surrogate endpoints? Should we use surrogate endpoints in adjuvant settings? Can surrogacy be extrapolated from one setting to another? What is the surrogacy of progression-free survival for OS and QOL? Why does PFS not correlated with OS or QOL? W[cell cut: 2101 characters, first 2000 kept]
rights: © 2024 The Author(s).
has PII: S2589-5370(24)00403-6
doi: 10.1016/j.eclinm.2024.102824
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Mittal A
      type: Person
      first name: Abhenil
      last name: Mittal
      member of: Department of Oncology, Northeast Cancer Center, Northern Ontario School of Medicine, Sudbury, ON, Canada.
  slot:
    index: 2
    item: Kim MS
      type: Person
      first name: Myung Sun
      last name: Kim
      member of: Hematology/Medical Oncology, Compass Oncology, Portland, OR, USA.
  slot:
    index: 3
    item: Dunn S
      type: Person
      first name: Shenna
      last name: Dunn
      member of: Department of Medicine, Queen's University, Kingston, Canada.
  slot:
    index: 4
    item: Wright K
      type: Person
      first name: Kristin
      last name: Wright
      member of: Department of Oncology, Queen's University, Kingston, Canada.
  slot:
    index: 5
    item: Gyawali B
      type: Person
      first name: Bishal
      last name: Gyawali
      member of: Department of Oncology, Queen's University, Kingston, Canada.Department of Public Health Sciences, Queen's University, Kingston, Canada.Division of Cancer Care and Epidemiology, Queen's University, Kingston, Canada.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2024-10
dp: 2024 Oct
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102824
has place of publication: England
source: EClinicalMedicine. 2024-10;76():102824.
volume: 76

Effect of digital health applications with or without gamification on physical activity and cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials.
pmid: 39764571
abstract: Use of health applications (apps) to support healthy lifestyles has intensified. Different app features may support effectiveness, including gamification defined as the use of game elements in a non-game situation. Whether health apps with gamification can impact behaviour change and cardiometabolic risk factors remains unknown. We conducted a systematic review and meta-analysis to determine the effect of health apps with gamification compared to non-gamified apps (control) on physical activity and cardiometabolic risk factors.MEDLINE, EMBASE, and Cochrane library databases were searched through May 21st, 2024. We included controlled trials in adults (≥1 years) of all health backgrounds, with intervention periods ≥8-weeks, assessing the effect of gamification strategies used in health behaviour apps on adherence, cardiometabolic risk factors, total energy, and dietary nutrients of concern. Independent reviewers extracted relevant data and assessed risk of bias. Outcomes included physical activity and cardiometabolic risk factors (adiposity, glycemia, lipids, blood pressure and dietary factors). Data were pooled using the inverse variance method and expressed as mean differences (MD) with 95% confidence intervals (CI). Certainty of evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Protocol registration was on ClinicalTrials.gov (NCT04633070).36 trials (49 trial comparisons, n = 10,079) met eligibility criteria; most targeted physical activity or weight loss. Use of gamification in apps compared to non-gamified interventions resulted in trivial increases in steps (489 steps/day [64 to 914]; high), and reductions in body mass index (-0.28 kg/m2 [-0.44 to -0.12]; moderate) and body weight (-0.70 kg [-1.18 to -0.22]; moderate), and small important reductions in body fat (-1.92% [-2.71 to -1.14]; high) and waist circumference (-1.16 cm [-1.93 to -0.39]; moderate). No differences were observed for other outcomes (very l[cell cut: 2370 characters, first 2000 kept]
rights: © 2024 The Authors.
has PII: S2589-5370(24)00377-8
doi: 10.1016/j.eclinm.2024.102798
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Nishi SK
      type: Person
      first name: Stephanie K
      last name: Nishi
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, Reus, Spain.Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus 43201, Spain.Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid 28029, Spain.School of Nutrition, Faculty of Community Services, Toronto Metropolitan University, Toronto, ON, Canada.
  slot:
    index: 2
    item: Kavanagh ME
      type: Person
      first name: Meaghan E
      last name: Kavanagh
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
  slot:
    index: 3
    item: Ramboanga K
      type: Person
      first name: Kimberly
      last name: Ramboanga
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.
  slot:
    index: 4
    item: Ayoub-Charette S
      type: Person
      first name: Sabrina
      last name: Ayoub-Charette
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
  slot:
    index: 5
    item: Modol S
      type: Person
      first name: Sébastien
      last name: Modol
      member of: School of Environment, Enterprise and Development, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
  slot:
    index: 6
    item: Dias GM
      type: Person
      first name: Goretty M
      last name: Dias
      member of: School of Environment, Enterprise and Development, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
  slot:
    index: 7
    item: Kendall CWC
      type: Person
      first name: Cyril W C
      last name: Kendall
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
  slot:
    index: 8
    item: Sievenpiper JL
      type: Person
      first name: John L
      last name: Sievenpiper
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Division of Endocrinology and Metabolism, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
  slot:
    index: 9
    item: Chiavaroli L
      type: Person
      first name: Laura
      last name: Chiavaroli
      member of: Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.
created: 2025-1-7T10:53
date last updated: 2025-01-07
issued: 2024-10
dp: 2024 Oct
created: 2025-1-7T04:46
e ISSN: 2589-5370
has issn l: 2589-5370
has NLM journal title abbreviation: EClinicalMedicine
publication name: EClinicalMedicine
language: eng
has national library of medicine journal id: 101733727
derived from: NLM
pg: 102798
has place of publication: England
source: EClinicalMedicine. 2024-10;76():102798.
volume: 76

Impartial Intergenerational Beneficence: The Psychology of Feeling (Equal) Intergenerational Concern for All Future Generations.
pmid: 39764575
abstract: Across a series of eight high-powered studies (N = 6,866), we develop a method for assessing impartial intergenerational beneficence, defined as intergenerational concern for all possible future generations. Across our studies, roughly 20% of participants displayed impartial intergenerational beneficence. Participants with impartial intergenerational beneficence expressed greater perceptions that future threats can be resolved, support for policies seeking to protect future generations of people, and a profound sense of responsibility for the long-term survival and prosperity of humanity. Similarly, associations with various future-oriented attitudes, patterns of prosociality, and longtermism-related behaviors and intentions were noted. This research thus introduces a method to capture impartiality in expressed intergenerational concern and finds that people who display impartial intergenerational concern endorse prosocial principles, such as altruism and utilitarianism, while also being more concerned about their own future, the future of others, and how they will be remembered by others.
doi: 10.1177/01461672241307800
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Syropoulos S
      type: Person
      first name: Stylianos
      last name: Syropoulos
      member of: Boston College, MA, USA.
  slot:
    index: 2
    item: Law KF
      type: Person
      first name: Kyle Fiore
      last name: Law
      member of: Boston College, MA, USA.
  slot:
    index: 3
    item: Kraft-Todd G
      type: Person
      first name: Gordon
      last name: Kraft-Todd
      member of: Boston College, MA, USA.
  slot:
    index: 4
    item: Young L
      type: Person
      first name: Liane
      last name: Young
      member of: Boston College, MA, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:46
e ISSN: 1552-7433
has issn l: 0146-1672
has NLM journal title abbreviation: Pers Soc Psychol Bull
publication name: Personality & social psychology bulletin
language: eng
has national library of medicine journal id: 7809042
derived from: NLM
pg: 1461672241307800
has place of publication: United States
source: Pers Soc Psychol Bull. 2025-01-07;():1461672241307800.

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions.
pmid: 39764565
abstract: Sarcopenia is defined as a muscle-wasting syndrome that occurs with accelerated aging, while cachexia is a severe wasting syndrome associated with conditions such as cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. Sarcopenia can be considered a component of cachexia, with the bidirectional interplay between adipose tissue and skeletal muscle potentially serving as a molecular mechanism for both conditions. However, the underlying mechanisms differ. Recognizing the interplay and distinctions between these disorders is essential for advancing both basic and translational research in this area, enhancing diagnostic accuracy and ultimately achieving effective therapeutic solutions for affected patients. This review discusses the muscle microenvironment's changes contributing to these conditions, recent therapeutic approaches like lifestyle modifications, small molecules, and nutritional interventions, and emerging strategies such as gene editing, stem cell therapy, and gut microbiome modulation. We also address the challenges and opportunities of multimodal interventions, aiming to provide insights into the pathogenesis and molecular mechanisms of sarcopenia and cachexia, ultimately aiding in innovative strategy development and improved treatments.
rights: © 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
has PII: MCO270030
doi: 10.1002/mco2.70030
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wang T
      type: Person
      first name: Tiantian
      last name: Wang
      member of: Department of Neurology West China Hospital of Sichuan University Chengdu Sichuan China.Institute of Brain Science and Brain-Inspired Technology of West China Hospital Sichuan University Chengdu Sichuan China.Department of Neurology Chengdu Shangjin Nanfu Hospital Chengdu Sichuan China.
  slot:
    index: 2
    item: Zhou D
      type: Person
      first name: Dong
      last name: Zhou
      member of: Department of Neurology West China Hospital of Sichuan University Chengdu Sichuan China.Institute of Brain Science and Brain-Inspired Technology of West China Hospital Sichuan University Chengdu Sichuan China.Department of Neurology Chengdu Shangjin Nanfu Hospital Chengdu Sichuan China.
  slot:
    index: 3
    item: Hong Z
      type: Person
      first name: Zhen
      last name: Hong
      member of: Department of Neurology West China Hospital of Sichuan University Chengdu Sichuan China.Institute of Brain Science and Brain-Inspired Technology of West China Hospital Sichuan University Chengdu Sichuan China.Department of Neurology Chengdu Shangjin Nanfu Hospital Chengdu Sichuan China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:46
e ISSN: 2688-2663
has issn l: 2688-2663
issue: 1
has NLM journal title abbreviation: MedComm (2020)
publication name: MedComm
language: eng
has national library of medicine journal id: 101769925
derived from: NLM
pg: e70030
has place of publication: China
source: MedComm (2020). 2025-01;6(1):e70030.
volume: 6

The Importance and Psychometric Soundness of an Instrument to Measure Holistic Nursing in NP Care.
pmid: 39764578
abstract: Background and Purpose: The Nurse Practitioner Holistic Caring Instrument (NPHCI) is a 19-item, investigator-developed instrument designed to measure holistic caring in nurse practitioner (NP) practice. This paper evaluates multi-sample psychometric testing of the instrument, describing data from three samples, with analysis supporting the NPHCI as a valid and reliable instrument. Methods: The NPHCI has been administered in patient, NP program faculty, and NP convenience samples. Development of the NPHCI was guided by Shuler's NP practice model and Swanson's theory of caring. Construct validity was estimated using Interitem correlation, exploratory factor analysis and confirmatory factor analysis. Reliability of the instrument was assessed in all three samples via Cronbach's alpha. Findings: Exploratory factor analysis consistently supported the identification of three subscales in the NPHCI, and confirmatory factor analysis demonstrated a good fit between the theoretical constructs and empirical indicators in the data. The instrument has demonstrated strong reliability in three samples. Conclusions: The NPHCI demonstrates acceptable reliability and validity but further psychometric testing is indicated.
doi: 10.1177/08980101241302354
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Kinchen E
      type: Person
      first name: Elizabeth
      last name: Kinchen
      member of: University of Central Florida, College of Nursing, Orlando, FL, USA.
  slot:
    index: 2
    item: Montoya V
      type: Person
      first name: Vicki
      last name: Montoya
      member of: University of Central Florida, College of Nursing, Orlando, FL, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:46
e ISSN: 1552-5724
has issn l: 0898-0101
has NLM journal title abbreviation: J Holist Nurs
publication name: Journal of holistic nursing : official journal of the American Holistic Nurses' Association
language: eng
has national library of medicine journal id: 8506709
derived from: NLM
pg: 8980101241302354
has place of publication: United States
source: J Holist Nurs. 2025-01-07;():8980101241302354.

Seeing Through the Fog: The Ability to Resolve Ambiguity Reduces Dishonesty.
pmid: 39764593
abstract: Ambiguity acts as a veil that can help conceal and justify dishonest behavior. While an individual's ability to disambiguate information in a task may help remove the veil of ambiguity and thus promote honesty, the relationship between ambiguity, ability, and dishonesty is currently unexplored. To investigate this, we employed an experimental design where participants attempted to resolve an ambiguous task and reported their performance. Results showed that ambiguity and dishonesty increase in unison. Importantly, the participants who resolved ambiguity acted less dishonestly (Study 1). In Studies 2a, 2b, and 3, we increased participants' ability by briefly training them to disambiguate the information presented in the task. The results showed that participants acted less dishonestly when their ability levels were increased. Overall, the findings indicate that dishonesty can be reduced not only by making tasks less ambiguous but also by enhancing an individual's ability to successfully resolve ambiguity.
doi: 10.1177/01461672241305687
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Puntiroli M
      type: Person
      first name: Michael
      last name: Puntiroli
      member of: University of Neuchâtel, Switzerland.
  slot:
    index: 2
    item: Kandul S
      type: Person
      first name: Serhiy
      last name: Kandul
      member of: University of Zurich, Switzerland.
  slot:
    index: 3
    item: Bezençon V
      type: Person
      first name: Valéry
      last name: Bezençon
      member of: University of Neuchâtel, Switzerland.
  slot:
    index: 4
    item: Lanz B
      type: Person
      first name: Bruno
      last name: Lanz
      member of: University of Neuchâtel, Switzerland.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:47
e ISSN: 1552-7433
has issn l: 0146-1672
has NLM journal title abbreviation: Pers Soc Psychol Bull
publication name: Personality & social psychology bulletin
language: eng
has national library of medicine journal id: 7809042
derived from: NLM
pg: 1461672241305687
has place of publication: United States
source: Pers Soc Psychol Bull. 2025-01-07;():1461672241305687.

A medical trailblazer in the Ottoman Empire: The legacy of Dr Caroline Frances Hamilton (1861-1944).
pmid: 39764594
abstract: This article explores the life and work of Dr Caroline F. Hamilton, one of the pioneering female physicians sent from the USA to the Ottoman Empire in the late 19th century. Over a career spanning three decades, Hamilton provided critical medical care, especially to women, at the Azariah Smith Memorial Hospital in Aintab, overcoming legal, cultural, and political obstacles to become one of the first women licensed to practise medicine in the region. Her contributions, particularly in treating Muslim women who had limited access to male doctors, were significant in advancing healthcare in a conservative society. Hamilton's role extended beyond direct patient care, she also trained local health workers, contributing to long-term improvements in healthcare. Her efforts during times of war, epidemics, and humanitarian crises exemplified her resilience and dedication. This article highlights Hamilton's broader legacy, examining how her work reflects the intersection of gender, medicine, and missionary activity in a complex geopolitical context while also contributing to the introduction of Western medical practices in the Ottoman Empire.
doi: 10.1177/09677720241304653
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: İskefiyeli Z
      type: Person
      first name: Zeynep
      last name: İskefiyeli
      member of: Faculty of Humanities and Social Sciences, Sakarya University, Sakarya, Turkey.
  slot:
    index: 2
    item: Yavuz F
      type: Person
      first name: Fikrettin
      last name: Yavuz
      member of: Faculty of Humanities and Social Sciences, Sakarya University, Sakarya, Turkey.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:47
e ISSN: 1758-1087
has issn l: 0967-7720
has NLM journal title abbreviation: J Med Biogr
publication name: Journal of medical biography
language: eng
has national library of medicine journal id: 9308895
derived from: NLM
pg: 9677720241304653
has place of publication: England
source: J Med Biogr. 2025-01-07;():9677720241304653.

Percutaneous Nephrostomy in Kidney Transplant Recipients: Incidence, Risk Factors, Complications and Outcomes.
pmid: 39764595
abstract: Ureteral stenosis is a frequent complication after kidney transplantation, causing significant morbidity and potential graft function impairment. Treatment options include conservative management, endourological procedures, surgical interventions and percutaneous nephrostomy (PCN). While PCN effectively relieves obstruction, it comes with its own complications. This study evaluates the risk factors, incidence, complications and outcomes of PCN in this population. We conducted a retrospective case series analysis of 98 kidney transplant recipients who underwent PCN. Data on demographics, clinical characteristics and procedural outcomes were collected and analysed to assess the incidence of complications and identify associated risk factors. Among the 98 recipients, the median age at transplant was 56 years, with 52% being male. The most common comorbidities included hypertension (75.5%) and diabetes mellitus (35.7%). Complications occurred in 38.8% of patients, with infections being the most frequent (74.4%), including urinary tract infections (28.9%) and pyelonephritis (22.4%). The primary organisms identified were gram-negative bacteria (55.1%). Reconstructive surgery was required in 35.7% of cases and patient survival was 83.7% at follow-up. In conclusion, PCN in kidney transplant recipients is associated with a high rate of complications, particularly infections. Effective management necessitates the identification and addressing of associated risk factors such as diabetes, elevated BMI and specific induction therapies. While PCN is vital for preserving graft function, further research should focus on refining clinical protocols and developing targeted preventive strategies for high-risk patients.
rights: © 2025 Asian Pacific Society of Nephrology.
doi: 10.1111/nep.14421
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Alhassoun A
      type: Person
      first name: Alia
      last name: Alhassoun
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
  slot:
    index: 2
    item: Alkhatib B
      type: Person
      first name: Bassel
      last name: Alkhatib
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
  slot:
    index: 3
    item: Idilbi A
      type: Person
      first name: Amro
      last name: Idilbi
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
  slot:
    index: 4
    item: Hallak MH
      type: Person
      first name: Mohamed Hussam
      last name: Hallak
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
  slot:
    index: 5
    item: Ghanem R
      type: Person
      first name: Roaa
      last name: Ghanem
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
  slot:
    index: 6
    item: Hanouneh T
      type: Person
      first name: Tareq
      last name: Hanouneh
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
  slot:
    index: 7
    item: Jarmi T
      type: Person
      first name: Tambi
      last name: Jarmi
      member of: Department of Transplant, Mayo Clinic Florida, Jacksonville, Florida, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:47
e ISSN: 1440-1797
has issn l: 1320-5358
issue: 1
has NLM journal title abbreviation: Nephrology (Carlton)
publication name: Nephrology (Carlton, Vic.)
language: eng
has national library of medicine journal id: 9615568
derived from: NLM
pg: e14421
has place of publication: Australia
has primary subject term: D016030Q000009
has primary subject term: D009403Q000009
has subject term: D000328
has subject term: D000368
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D015994
has subject term: D011183Q000453Q000209
has subject term: D012189
has subject term: D012307
has subject term: D013997
has subject term: D016896
has subject term: D014517Q000453Q000209Q000601
source: Nephrology (Carlton). 2025-01;30(1):e14421.
volume: 30

Rethinking polypharmacy: empowering junior doctors to tackle a chronic condition in modern practice.
pmid: 39764597
has PII: 7944092
doi: 10.1093/postmj/qgae198
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Jerjes W
      type: Person
      first name: Waseem
      last name: Jerjes
      member of: Department of Primary Care and Public Health, Faculty of Medicine, Imperial College London, 86 Wood Lane, London, W12 0BZ, United Kingdom.Polypharmacy Action Learning Sets, Imperial College Health Partners, 307 Euston Road, London, NW1 3AD, United Kingdom.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:48
e ISSN: 1469-0756
has issn l: 0032-5473
has NLM journal title abbreviation: Postgrad Med J
publication name: Postgraduate medical journal
language: eng
has national library of medicine journal id: 0234135
derived from: NLM
has place of publication: England
source: Postgrad Med J. 2025-01-07;():.

Eugene Hertoghe (1860-1928): Pioneer in endocrinology and the treatment of hypothyroidism.
pmid: 39764601
abstract: Eugène Hertoghe (1860-1928), a Belgian internist and former vice-president of the Royal Academy of Medicine of Belgium, made significant contributions to the understanding and treatment of chronic hypothyroidism. He provided a detailed clinical description of the condition, emphasizing its multisystemic manifestations and hereditary aspects. Hertoghe also documented the therapeutic use of thyroid extract, reporting its effectiveness in alleviating symptoms of hypothyroidism. Among his contributions, he described the Hertoghe sign, a rare clinical feature characterized by the loss of the outer third of the eyebrows, commonly associated with myxoedema, as well as with cases of toxic poisoning, infections, and atopic dermatitis.
doi: 10.1177/09677720241307877
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Tekiner H
      type: Person
      first name: Halil
      last name: Tekiner
      member of: Department of the History of Medicine and Ethics, Erciyes University School of Medicine, Melikgazi, Kayseri, Türkiye.
  slot:
    index: 2
    item: Yale ES
      type: Person
      first name: Eileen S
      last name: Yale
      member of: Department of Medicine, Nova Southeastern University Medical School, Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA.
  slot:
    index: 3
    item: Yale SH
      type: Person
      first name: Steven H
      last name: Yale
      member of: Department of Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:48
e ISSN: 1758-1087
has issn l: 0967-7720
has NLM journal title abbreviation: J Med Biogr
publication name: Journal of medical biography
language: eng
has national library of medicine journal id: 9308895
derived from: NLM
pg: 9677720241307877
has place of publication: England
source: J Med Biogr. 2025-01-07;():9677720241307877.

Mimicking Nature: Effect of Architectural Design Inspired by Cancellous Bone on the Biological Response of hMSC Cultured on Titanium Scaffolds Fabricated by Laser Beam Powder Bed Fusion.
pmid: 39764607
abstract: Bone tissue regeneration can be affected by various architectonical features of 3D porous scaffold, for example, pore size and shape, strut size, curvature, or porosity. However, the design of additively manufactured structures studied so far was based on uniform geometrical figures and unit cell structures, which often do not resemble the natural architecture of cancellous bone. Therefore, the aim of this study was to investigate the effect of architectonical features of additively manufactured (aka 3D printed) titanium scaffolds designed based on microtomographic scans of fragments of human femurs of individuals of different ages on in vitro response of human bone-derived mesenchymal stem cells (hMSC). Four different types of titanium scaffold (33Y, 48Y, 56Y, and 63Y, where the number indicates the age of the individual) were fabricated using laser beam powder bed fusion (PBF-LB) and characterized with respect to the dimensional features, permeability, and stiffness. hMSC were seeded onto the scaffolds and MTS, DNA, alkaline phosphatase, and alizarin red assays were used to study cell viability, proliferation, and osteogenic differentiation. Microcomputed tomography revealed that the largest average pore size was in scaffolds 63Y (543 ± 200 μm), which was nearly twice as large as the smallest pores in scaffolds 56Y. Moreover, scaffolds 63Y exhibited the highest porosity (~61%), while the other architectures had porosity of ~43%-44%. Scaffolds 63Y also had the lowest surface area-to-volume ratio (11.07 ± 0.05 mm-1), whereas scaffolds 56Y had the highest (14.80 ± 0.06 mm-1). Furthermore, scaffolds 33Y had the largest strut size (398 ± 124 μm), exceeding the size in scaffolds 56Y (the smallest strut size) by over 1.5 times. CFD simulations indicated that the hydraulic permeability was the highest for scaffolds 63Y (5.24 × 10-9 m2; order of magnitude higher than in the other architectures). Stiffness of the investigated scaffolds, determined by finite element modeling[cell cut: 2669 characters, first 2000 kept]
rights: © 2025 Wiley Periodicals LLC.
doi: 10.1002/jbm.a.37860
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Idaszek J
      type: Person
      first name: Joanna
      last name: Idaszek
      member of: Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
  slot:
    index: 2
    item: Heljak M
      type: Person
      first name: Marcin
      last name: Heljak
      member of: Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
  slot:
    index: 3
    item: Szlązak K
      type: Person
      first name: Karol
      last name: Szlązak
      member of: Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
  slot:
    index: 4
    item: Jankowski K
      type: Person
      first name: Krzysztof
      last name: Jankowski
      member of: Faculty of Mechanical and Industrial Engineering, Warsaw University of Technology, Warsaw, Poland.
  slot:
    index: 5
    item: Chmielewska-Wysocka A
      type: Person
      first name: Agnieszka
      last name: Chmielewska-Wysocka
      member of: Multidisciplinary Research Center, Cardinal Stefan Wyszynski University in Warsaw, Dziekanow Lesny, Poland.
  slot:
    index: 6
    item: Wysocki B
      type: Person
      first name: Bartłomiej
      last name: Wysocki
      member of: Multidisciplinary Research Center, Cardinal Stefan Wyszynski University in Warsaw, Dziekanow Lesny, Poland.
  slot:
    index: 7
    item: Skalski K
      type: Person
      first name: Konstanty
      last name: Skalski
      member of: Faculty of Mechanical and Industrial Engineering, Warsaw University of Technology, Warsaw, Poland.
  slot:
    index: 8
    item: Święszkowski W
      type: Person
      first name: Wojciech
      last name: Święszkowski
      member of: Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T04:48
e ISSN: 1552-4965
has issn l: 1549-3296
issue: 1
has NLM journal title abbreviation: J Biomed Mater Res A
publication name: Journal of biomedical materials research. Part A
language: eng
has national library of medicine journal id: 101234237
derived from: NLM
pg: e37860
has place of publication: United States
has primary subject term: D054457Q000737
has primary subject term: D014025Q000737
has primary subject term: D059630Q000166Q000378
has primary subject term: D000071556Q000166
has subject term: D006801
has subject term: D008875
has subject term: D010012
has subject term: D016062
has subject term: D000328
has subject term: D002478
has subject term: D002454
has subject term: D007834
has subject term: D066330
has subject term: D011208
has subject term: D049109
has subject term: D002470
has subject term: D008297
has subject term: D040761Q000737
source: J Biomed Mater Res A. 2025-01;113(1):e37860.
volume: 113

Interaction of the Gut-Liver-Brain Axis and the sterolbiome with sexual dysfunction in patients with cirrhosis.
pmid: 39764615
abstract: There is a complex interplay between the gut microbes, liver, and central nervous system, a gut-liver-brain axis, where the brain impacts intestinal and hepatic function while the gut and liver can impact cognition and mental status. Dysregulation of this axis can be seen in numerous diseases. Hepatic encephalopathy, a consequence of cirrhosis, is perhaps the best studied perturbation of this system. However, patients with cirrhosis have been shown to have increased incidence of other disorders of mental health which may be otherwise less clinically identifiable. Sexual dysfunction affects a large proportion of patients with cirrhosis and is associated with decreased quality of life. Screening for sexual dysfunction in patients with cirrhosis is often overlooked, and even when identified, treatment options are limited, particularly in patients with advanced liver disease. The mechanism by which patients with cirrhosis develop sexual dysfunction is multifactorial, but a key driver of this clinical manifestation is alterations in circulating sex hormones. In patients with cirrhosis, low serum sex hormones have been shown to be associated with higher mortality regardless of MELD score. The gut microbiome has been shown to have an immense metabolic capacity to metabolize steroid hormones. This sterolbiome has already been implicated in other disease processes and has been linked to low circulating sex hormones, suggesting a new mechanism by which sex hormones may be altered in disease states where the gut-liver-brain axis is disrupted. The aim of this review is to cover sex hormone changes and sexual dysfunction in cirrhosis, examine the gut microbiome and its metabolic capacity, particularly for steroid hormones, and consider how microbial changes using fecal microbiota transplant could modulate sexual dysfunction.
doi: 10.1080/19490976.2024.2446390
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Harris SC
      type: Person
      first name: Spencer C
      last name: Harris
      member of: Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
  slot:
    index: 2
    item: Bajaj JS
      type: Person
      first name: Jasmohan S
      last name: Bajaj
      member of: Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-12
dp: 2025 Dec
created: 2025-1-7T04:53
e ISSN: 1949-0984
has issn l: 1949-0976
issue: 1
has NLM journal title abbreviation: Gut Microbes
publication name: Gut microbes
language: eng
has national library of medicine journal id: 101495343
derived from: NLM
pg: 2446390
has place of publication: United States
has primary subject term: D008103Q000150Q000378
has primary subject term: http://id.nlm.nih.gov/mesh/D000069196
has primary subject term: D000087502Q000502
has primary subject term: D012735Q000378Q000209Q000503
has primary subject term: D008099Q000378
has subject term: D006801
has subject term: D013261Q000378
has subject term: D001921Q000378
has subject term: D012739Q000378
has subject term: D000818
has subject term: D011788
source: Gut Microbes. 2025-12;17(1):2446390.
volume: 17

Characteristics and outcomes of patients with repeat rapid response team activations in a tertiary centre in Singapore.
pmid: 39764616
abstract: Rapid response teams (RRTs) are prevalent in healthcare institutions worldwide. Repeated activations are associated with increased morbidity and higher resource utilisation, and represent a heterogeneous population that may benefit from early identification. To date, there are no published data on repeat RRT activations in Singapore. We aimed to compare the characteristics and outcomes between patients who required single versus multiple RRT activations.We conducted a prospective cohort study of daytime RRT activations from February 2018 to June 2020 in Singapore General Hospital. Repeat activations were defined as patients who had two or more activations during their admission. Patient demographics, clinical characteristics, RRT interventions, patient disposition after activation and hospital length of stay were recorded. The primary outcome of interest was in-hospital mortality.A total of 1055 patients were included, with 85 requiring repeat RRT activations. There was no significant difference in comorbidities and functional performance status at the time of first activation between patients with single versus repeated activations. Patients with repeat activations had more days in hospital before their index activation, a longer hospital length of stay and higher in-hospital mortality. Repeat activations had the strongest association with mortality on multivariate analysis.Our study found that repeat RRT activations were significantly associated with higher in-hospital mortality rates and increased hospital length of stay, independent of age, performance status and comorbidities. The results of our study highlight the need for early recognition and intervention in this patient group and discussion on goals of care when appropriate.
rights: Copyright © 2025 Singapore Medical Journal.
has PII: 00077293-990000000-00174
doi: 10.4103/singaporemedj.SMJ-2024-027
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Koh SHM
      type: Person
      first name: Siew Hui Michelle
      last name: Koh
      member of: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
  slot:
    index: 2
    item: Young SL
      type: Person
      first name: Si Ling
      last name: Young
      member of: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
  slot:
    index: 3
    item: Tan QL
      type: Person
      first name: Qiao Li
      last name: Tan
      member of: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
  slot:
    index: 4
    item: Ng LS
      type: Person
      first name: Lit Soo
      last name: Ng
      member of: Specialty Nursing, Nursing Division, Singapore General Hospital, Singapore.
  slot:
    index: 5
    item: Ko JP
      type: Person
      first name: Joanna Phone
      last name: Ko
      member of: Specialty Nursing, Nursing Division, Singapore General Hospital, Singapore.
  slot:
    index: 6
    item: Teo CW
      type: Person
      first name: Constance Wei-Shan
      last name: Teo
      member of: Respiratory Therapy Unit, Singapore General Hospital, Singapore.
  slot:
    index: 7
    item: Chai HZ
      type: Person
      first name: Hui Zhong
      last name: Chai
      member of: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
  slot:
    index: 8
    item: Goh KJ
      type: Person
      first name: Ken Junyang
      last name: Goh
      member of: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
created: 2025-1-7T06:22
date last updated: 2025-01-08
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:53
e ISSN: 2737-5935
has issn l: 0037-5675
has NLM journal title abbreviation: Singapore Med J
publication name: Singapore medical journal
language: eng
has national library of medicine journal id: 0404516
derived from: NLM
has place of publication: India
source: Singapore Med J. 2025-01-07;():.

Necrotising fasciitis in the elderly: comparison between patients aged 60 years and older and those younger than 60 years.
pmid: 39764628
abstract: Increasing age is associated with an increased incidence of necrotising fasciitis. In this study, we aimed to compare the clinical presentation, investigations, microbiology and clinical outcome in elderly (age ≥60 years) and nonelderly (age <60 years) patients with extremity necrotising fasciitis.A retrospective review of patients with extremity necrotising fasciitis who were surgically treated between January 2005 and December 2021 was conducted. The following patient outcomes were studied: amputation and mortality rates, length of stay, performance of surgery within 24 h and accuracy of diagnosis at presentation.A total of 167 patients were treated. Of these patients, 66 (39.5%) were aged ≥60 years and 101 (60.5%) were aged <60 years. Elderly patients were more likely to have ischaemic heart disease ( P = 0.001), immunosuppression ( P = 0.019) and bullae ( P = 0.025) on presentation. Significantly more elderly patients had monomicrobial gram-negative infections ( P = 0.006). Elderly patients had significantly higher amputation (42.4% vs. 22.8%, P = 0.01) and mortality (34.8% vs. 18.8%, P = 0.02) rates.In patients aged ≥60 years, necrotising fasciitis of the extremities is associated with significantly increased risk of amputation and mortality. It is important for the treating surgeon to be aware of this association, so that early appropriate empirical antibiotics and radical surgical debridement can be initiated and the patient appropriately counselled.
rights: Copyright © 2025 Singapore Medical Journal.
has PII: 00077293-990000000-00173
doi: 10.4103/singaporemedj.SMJ-2023-236
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Tan JJH
      type: Person
      first name: Jonathan Jiong Hao
      last name: Tan
      member of: Department of Orthopaedic Surgery, National University Health System, Singapore.
  slot:
    index: 2
    item: Hui SJ
      type: Person
      first name: Si Jian
      last name: Hui
      member of: Department of Orthopaedic Surgery, National University Health System, Singapore.
  slot:
    index: 3
    item: Tan SJH
      type: Person
      first name: Shawn Jia Hwang
      last name: Tan
      member of: Nuffield Orthopaedic Centre, Oxford University Hospitals, UK.
  slot:
    index: 4
    item: Chan YH
      type: Person
      first name: Yiong Huak
      last name: Chan
      member of: Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  slot:
    index: 5
    item: Tham WYW
      type: Person
      first name: Wei Yang Wilson
      last name: Tham
      member of: Department of Orthopaedic Surgery, National University Health System, Singapore.
  slot:
    index: 6
    item: Tan JYH
      type: Person
      first name: Joel Yong Hao
      last name: Tan
      member of: Department of Orthopaedic Surgery, National University Health System, Singapore.
  slot:
    index: 7
    item: Puhaindran ME
      type: Person
      first name: Mark Edward
      last name: Puhaindran
      member of: Department of Hand and Reconstructive Microsurgery, National University Health System, Singapore.
  slot:
    index: 8
    item: Hong CC
      type: Person
      first name: Choon Chiet
      last name: Hong
      member of: Department of Orthopaedic Surgery, National University Health System, Singapore.
created: 2025-1-7T06:22
date last updated: 2025-01-08
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T04:54
e ISSN: 2737-5935
has issn l: 0037-5675
has NLM journal title abbreviation: Singapore Med J
publication name: Singapore medical journal
language: eng
has national library of medicine journal id: 0404516
derived from: NLM
has place of publication: India
source: Singapore Med J. 2025-01-07;():.

Elevated LINC00115 expression correlates with aggressive endometrial cancer phenotypes via JAK/STAT pathway modulation.
pmid: 39764645
abstract: This study systematically explores the oncogenic role of the long non-coding RNA (lncRNA) LINC00115 in endometrial cancer (EC) and reveals its unique mechanism in promoting proliferation, invasion, and metastasis via the JAK/STAT signaling pathway. LINC00115 is significantly upregulated in EC tissues and closely associated with advanced TNM staging and lymph node metastasis. Functional assays showed that knockdown of LINC00115 suppressed EC cell proliferation, invasion, and metastasis, while overexpression enhanced these malignant behaviors. In vivo models confirmed that LINC00115 overexpression accelerates tumor growth and metastasis. Our study is the first to identify LINC00115 as a key activator of the JAK/STAT pathway through direct interaction with KH-type Splicing Regulatory Protein (KHSRP), a previously unrecognized mechanism in EC. This finding provides new insights into lncRNA-mediated signaling regulation and highlights LINC00115 as a novel biomarker and promising therapeutic target for EC, offering a theoretical basis for developing targeted therapies.
rights: © The Author(s) 2025. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: 7944087
doi: 10.1093/hmg/ddae194
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zhao Z
      type: Person
      first name: Zheqi
      last name: Zhao
      member of: Department of Reproductive Medicine, The First Affiliated Hospital of Henan University of CM, No. 19, Renmin Road, Jinshui District, Zhengzhou City, Henan Province, China.The First Clinical Medical College of Henan University of Traditional Chinese Medicine, No. 19, Renmin Road, Jinshui District, Zhengzhou City, Henan Province, China.
  slot:
    index: 2
    item: Liu Y
      type: Person
      first name: Yangyang
      last name: Liu
      member of: School of Medicine of Henan University, North Section of Jinming Avenue, Longting District, Kaifeng City, Henan Province, China.
  slot:
    index: 3
    item: Wang M
      type: Person
      first name: Mengyao
      last name: Wang
      member of: School of Medicine of Henan University, North Section of Jinming Avenue, Longting District, Kaifeng City, Henan Province, China.
  slot:
    index: 4
    item: Wei A
      type: Person
      first name: Aiwu
      last name: Wei
      member of: Department of Reproductive Medicine, The First Affiliated Hospital of Henan University of CM, No. 19, Renmin Road, Jinshui District, Zhengzhou City, Henan Province, China.The First Clinical Medical College of Henan University of Traditional Chinese Medicine, No. 19, Renmin Road, Jinshui District, Zhengzhou City, Henan Province, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:03
e ISSN: 1460-2083
has issn l: 0964-6906
has NLM journal title abbreviation: Hum Mol Genet
publication name: Human molecular genetics
language: eng
has national library of medicine journal id: 9208958
derived from: NLM
has place of publication: England
source: Hum Mol Genet. 2025-01-07;():.

Development, Measurement Properties and Reference Values of the Upper Extremity Motor Coordination Test: A New Motor Coordination Test of the Upper Limbs.
pmid: 39764648
abstract: To develop a new test to assess the motor coordination of the upper limbs, and to investigate the test-retest and inter-rater reliability, construct validity, standard error of measurement (SEM), minimum detectable change (MDC), and the reference values.The Upper Extremity Motor Coordination Test (UEMOCOT)was applied for 20 s, with the individual touching two targets (one right and one left) as quickly as possible, first with the hand (manual task) and then with the index finger (finger task). To test-retest reliability, the UEMOCOT was administered two times. To ensure inter-rater reliability, the test was scored simultaneously by two assessors. For convergent construct validity, the Box and Block Test (BBT) and the Nine Hole Peg Test (NHPT) were applied. Reference values were established according to sex, age, and limb side (dominant/non-dominant).Inter-rater and test-retest reliability, for both tasks and limbs, were good with all the intraclass correlation coefficient above 0.90. Regarding convergent construct validity, the UEMOCOT manual task, for both sides, correlated moderately with BBT (0.59 ≤ r ≤ 0.64; p < 0.01), while the UEMOCOT finger task, for both sides, correlated moderately with NHPT (-0.57 ≤ r ≤ -0,58; p < 0.01). The SEM values were adequate, and the MDC for manual and finger tasks were 11/8 and 6/6 (dominant/non-dominant), respectively. Young people, men, and the dominant limb showed higher scores, indicating better coordination.The results showed that UEMOCOT is valid and reliable for assessing the motor coordination of the upper limbs, with adequate SEM values and MDC values ranging from 6 to 11. Finally, UEMOCOT reference values were established according to sex, age, and upper limb side.
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1002/pri.70022
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ribeiro JVD
      type: Person
      first name: João Victor Drummond
      last name: Ribeiro
      member of: Department of Physiotherapy, Centro Universitário FUNCESI, Itabira, Brazil.
  slot:
    index: 2
    item: da Silva JR
      type: Person
      first name: Josué Rodrigues
      last name: da Silva
      member of: Department of Physiotherapy, Centro Universitário FUNCESI, Itabira, Brazil.
  slot:
    index: 3
    item: Paulo LJL
      type: Person
      first name: Laura Júnia Leite
      last name: Paulo
      member of: Department of Physiotherapy, Centro Universitário FUNCESI, Itabira, Brazil.
  slot:
    index: 4
    item: Avelino PR
      type: Person
      first name: Patrick Roberto
      last name: Avelino
      member of: Department of Physiotherapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  slot:
    index: 5
    item: de Menezes KKP
      type: Person
      first name: Kênia Kiefer Parreiras
      last name: de Menezes
      member of: Department of Physiotherapy, Centro Universitário FUNCESI, Itabira, Brazil.Department of Physiotherapy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T05:03
e ISSN: 1471-2865
has issn l: 1358-2267
issue: 1
has NLM journal title abbreviation: Physiother Res Int
publication name: Physiotherapy research international : the journal for researchers and clinicians in physical therapy
language: eng
has national library of medicine journal id: 9612022
derived from: NLM
pg: e70022
has place of publication: United States
has primary subject term: D034941Q000502
has subject term: D006801
has subject term: D012016
has subject term: D008297
has subject term: D005260
has subject term: D015203
has subject term: D000328
has subject term: D008875
has subject term: D009048Q000502
has subject term: D055815
has subject term: D000368
has subject term: D000293
has subject term: D064368
has subject term: D011597Q000502
source: Physiother Res Int. 2025-01;30(1):e70022.
volume: 30

Innovative Integration of Robotic-Assisted Laparoscopic Telesurgery and Quantum Cryptography Communication in Urology: Clinical Application and Initial Experience.
pmid: 39764650
abstract: The emergence of telesurgery has received global interest, with secure network transmission identified as a crucial determinant of its success. This study aimed to evaluate the safety and viability of employing quantum cryptography communication in remote partial nephrectomy.The surgeon operated on the patient from a distance of over 260 km using remote control of a surgical robot. Key evaluation metrics for the telesurgery procedure included success rate, incidence of complications, network latency, and packet loss.The average BMI of these patients was 29.4 kg/m2, the average warm ischaemia time was 26 min, and the packet loss rate was 0%. Postoperative patient recovery, as indicated by follow-up results, was favourable.We introduced a novel telesurgical paradigm for partial nephrectomy based on quantum cryptography communication. The application of pioneering technology provides patients with a safer choice for telemedical treatment and promotes the application of telesurgery.
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1002/rcs.70028
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Chu G
      type: Person
      first name: Guangdi
      last name: Chu
      member of: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  slot:
    index: 2
    item: Yang X
      type: Person
      first name: Xuecheng
      last name: Yang
      member of: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  slot:
    index: 3
    item: Zhang X
      type: Person
      first name: Xin
      last name: Zhang
      member of: Key Laboratory of Mechanism Theory and Equipment Design, Ministry of Education, Tianjin, China.
  slot:
    index: 4
    item: Guan B
      type: Person
      first name: Bo
      last name: Guan
      member of: Key Laboratory of Mechanism Theory and Equipment Design, Ministry of Education, Tianjin, China.Institute of Medical Robotics and Intelligent Systems of Tianjin University, Tianjin, China.
  slot:
    index: 5
    item: Zhao J
      type: Person
      first name: Jianchang
      last name: Zhao
      member of: National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China.
  slot:
    index: 6
    item: Gao Y
      type: Person
      first name: Yuan
      last name: Gao
      member of: Key Laboratory of Mechanism Theory and Equipment Design, Ministry of Education, Tianjin, China.Institute of Medical Robotics and Intelligent Systems of Tianjin University, Tianjin, China.
  slot:
    index: 7
    item: Yuan Y
      type: Person
      first name: Yi
      last name: Yuan
      member of: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  slot:
    index: 8
    item: Cao Y
      type: Person
      first name: Yuxuan
      last name: Cao
      member of: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
  slot:
    index: 9
    item: Wang S
      type: Person
      first name: Shuxin
      last name: Wang
      member of: Key Laboratory of Mechanism Theory and Equipment Design, Ministry of Education, Tianjin, China.Institute of Medical Robotics and Intelligent Systems of Tianjin University, Tianjin, China.
  slot:
    index: 10
    item: Li J
      type: Person
      first name: Jianmin
      last name: Li
      member of: Key Laboratory of Mechanism Theory and Equipment Design, Ministry of Education, Tianjin, China.Institute of Medical Robotics and Intelligent Systems of Tianjin University, Tianjin, China.
  slot:
    index: 11
    item: Niu H
      type: Person
      first name: Haitao
      last name: Niu
      member of: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.Key Laboratory, Department of Urology and Andrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-02
dp: 2025 Feb
created: 2025-1-7T05:03
e ISSN: 1478-596X
has issn l: 1478-5951
issue: 1
has NLM journal title abbreviation: Int J Med Robot
publication name: The international journal of medical robotics + computer assisted surgery : MRCAS
language: eng
has national library of medicine journal id: 101250764
derived from: NLM
pg: e70028
has place of publication: England
has primary subject term: D065287Q000379
has primary subject term: D010535Q000379
has primary subject term: D009392Q000379
has primary subject term: D017216
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D005260
has subject term: D014572Q000379
has subject term: D000368
has subject term: D000328
source: Int J Med Robot. 2025-02;21(1):e70028.
volume: 21

Stigma, Depression, and Attitudes Towards Seeking Psychological Help Among Nurses: The Role of Personal Stigma as an Inconsistent Mediator.
pmid: 39764655
abstract: Identifying whether perceived stigma or personal stigma more significantly affects nurses' attitudes towards seeking psychological help is essential for effectively addressing current challenges and facilitating early intervention for the well-being of nurses and their patients.The aim of this study was to explore the mediating roles of personal stigma and depression in the relationship between perceived stigma among nurses and their attitudes towards seeking psychological help.The sample of this descriptive cross-sectional study consisted of 302 nurses working in a university hospital in southern Turkey, selected using the purposive sampling method, between April 1 and May 1, 2021. Data collection tools were Personal Information Form, Attitudes Towards Seeking Psychological Help Scale-Short Form, Depression Stigma Scale, and Beck Depression Inventory. The data were analyzed using SPSS version 26.0. Correlation and regression analyzes were used to examine the relationships between attitudes towards seeking psychological help, personal stigma, perceived stigma, and Beck depression levels. Mann-Whitney U and Kruskal-Wallis tests were employed to compare scale scores across socio-demographic variables. The mediation models were tested with variables such as perceived stigma, personal stigma, and Beck depression levels as mediators. Results were presented with 95% confidence intervals, and significance was set at p < 0.05.Attitudes towards seeking psychological help were negatively influenced by nurses' stigma levels, especially, by personal stigma levels. Additionally, nurses' attitudes were positively influenced by their unit of work and the presence of a chronic illness, while being male and experiencing higher levels of personal stigma had a negative impact. No significant relationships were found between perceived stigma, personal stigma, and depression levels.High levels of personal stigma negatively affect attitudes towards seeking psychological help; however, wh[cell cut: 2622 characters, first 2000 kept]
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1111/jep.14272
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Özel Erçel N
      type: Person
      first name: Nihan
      last name: Özel Erçel
      member of: Department of Biostatistics and Medical Informatics, Mersin University Faculty of Medicine, Mersin, Turkey.
  slot:
    index: 2
    item: Altundal Duru H
      type: Person
      first name: Hilal
      last name: Altundal Duru
      member of: Department of Nursing, Çankırı Karatekin University Faculty of Health Science, Çankırı, Turkey.
  slot:
    index: 3
    item: Temel G
      type: Person
      first name: Gülhan
      last name: Temel
      member of: Department of Biostatistics and Medical Informatics, Mersin University Faculty of Medicine, Mersin, Turkey.
  slot:
    index: 4
    item: Yılmaz M
      type: Person
      first name: Mualla
      last name: Yılmaz
      member of: Department of Mental Health Nursing, Mersin University Faculty of Nursing, Mersin, Turkey.
  slot:
    index: 5
    item: Çolak C
      type: Person
      first name: Cemil
      last name: Çolak
      member of: Department of Biostatistics and Medical Informatics, İnönü University Faculty of Medicine, Malatya, Turkey.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025-02
dp: 2025 Feb
created: 2025-1-7T05:12
e ISSN: 1365-2753
has issn l: 1356-1294
issue: 1
has NLM journal title abbreviation: J Eval Clin Pract
publication name: Journal of evaluation in clinical practice
language: eng
has national library of medicine journal id: 9609066
derived from: NLM
pg: e14272
has place of publication: England
has primary subject term: D057545
has primary subject term: D003863Q000523
has primary subject term: D001291
has subject term: D006801
has subject term: D005260
has subject term: D003430
has subject term: D014421
has subject term: D008297
has subject term: D000328
has subject term: D010342Q000523
has subject term: D008875
has subject term: D055815
has subject term: D009741Q000523
has subject term: D009726Q000523
source: J Eval Clin Pract. 2025-02;31(1):e14272.
volume: 31

Comparative anatomy of the subclavius muscle and clavicle: a histological study using human, swine and mouse fetuses.
pmid: 39764658
abstract: Some mammals including the swine carry a fibrous vestigial clavicle, but a subclavius muscle (SBM) extends between the first rib and the supraspinatus muscle surface fascia. We aimed to examine development of the SBM and clavicle for finding a specific factor to provide the curious morphology.Histological sections of early- and midterm fetuses of the swine, human and mouse were observed and compared at the almost same morphological stage.In all three species, the initial SBM was seen extending between the cartilaginous first rib and a mesenchymal clavicle. At the early stage, the human and mouse fetuses carried the mesenchymal manubrium sterni above the heart bulbus as well as the acromion above the humeral head. However, in the swine fetus, the manubrium remained far caudal to the first rib, while the acromion was in the laterocaudal side of the glenohumeral joint. In place of the acromion, the swine supraspinatus muscle was large and covered the humeral head. At midterm, the human and mouse SBM attached to the membranous bone of the clavicle. Endochondral ossification occurred at the lateral and medial ends of the human clavicle, while it was seen in the medial half of the mouse clavicle anlage with a homogenous eosinophilic matrix.The swine clavicle seemed to lose the endochondral parts due to the caudally-shifted manubrium sterni and acromion. The medial or clavicular attachment of the swine SBM might migrate to a nearby fascia of the supraspinatus muscle in the later development.
has PII: VM/OJS/J/102531
doi: 10.5603/fm.102531
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Verdugo-López S
      type: Person
      first name: Samuel
      last name: Verdugo-López
      member of: Department of Anatomy and Embryology, School of Medicine, Complutense University, Madrid, Spain.
  slot:
    index: 2
    item: Kitamura K
      type: Person
      first name: Kei
      last name: Kitamura
      member of: Department of Histology and Developmental Biology, Tokyo Dental College, Tokyo, Japan. kitamurakei@tdc.ac.jp.
  slot:
    index: 3
    item: Murakami G
      type: Person
      first name: Gen
      last name: Murakami
      member of: Division of Internal Medicine, Iwamizawa Asuka Hospital, Hokkaido, Japan.
  slot:
    index: 4
    item: Rodríguez-Vázquez JF
      type: Person
      first name: Jose Francisco
      last name: Rodríguez-Vázquez
      member of: Department of Anatomy and Embryology, School of Medicine, Complutense University, Madrid, Spain.
  slot:
    index: 5
    item: Yamamoto H
      type: Person
      first name: Hitoshi
      last name: Yamamoto
      member of: Department of Histology and Developmental Biology, Tokyo Dental College, Tokyo, Japan.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:12
e ISSN: 1644-3284
has issn l: 0015-5659
has NLM journal title abbreviation: Folia Morphol (Warsz)
publication name: Folia morphologica
language: eng
has national library of medicine journal id: 0374620
derived from: NLM
has place of publication: Poland
source: Folia Morphol (Warsz). 2025-01-07;():.

Anatomy education in transition: examining medical student experiences during the distance education.
pmid: 39764660
abstract: Distance education emerged as a potential solution to enhance access, standardize content, and facilitate updates. However, student perceptions varied widely. The COVID-19 pandemic prompted a rapid shift towards distance education in anatomy, presenting challenges and opportunities for medical students globally. A crucial area of study is how distant learning, utilized once more during the 2023 earthquakes, affects medical education and students. This study investigates medical students' perspectives on anatomy education in remote and in-person settings.This study involved surveying first and second-year medical students to gather their opinions and experiences regarding distance and face-to-face education. The advantages and disadvantages of anatomy distance education were then analyzed based on the students' responses.Individuals who preferred traditional in-person education were less inclined to utilize digital resources, whereas those who selected remote education shown a greater preference for the usage of digital resources (p < 0.001). Similarly, individuals who favored traditional in-person education exhibited low levels of confidence in online exams, whereas those who preferred remote education shown high levels of confidence (p < 0.001).Considering the results of our study and our location in a potentially hazardous area affected by the North Anatolian Fault line in the Marmara Region of Türkiye, we believe that our experiences with distance education will help in effectively maintaining the Anatomy in Medicine education process.
has PII: VM/OJS/J/103433
doi: 10.5603/fm.103433
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Özkan M
      type: Person
      first name: Mazhar
      last name: Özkan
      member of: Tekirdağ Namık Kemal University School of MedicineTekirdağ, Türkiye.
  slot:
    index: 2
    item: Alpay M
      type: Person
      first name: Meltem
      last name: Alpay
      member of: Recep Tayyip Erdoğan University School of Medicine, Department of Anatomy, Rize, Türkiye.
  slot:
    index: 3
    item: Zeybek A
      type: Person
      first name: Ali
      last name: Zeybek
      member of: Tekirdağ Namık Kemal University School of MedicineTekirdağ, Türkiye. alize05@yahoo.com.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:12
e ISSN: 1644-3284
has issn l: 0015-5659
has NLM journal title abbreviation: Folia Morphol (Warsz)
publication name: Folia morphologica
language: eng
has national library of medicine journal id: 0374620
derived from: NLM
has place of publication: Poland
source: Folia Morphol (Warsz). 2025-01-07;():.

The depth of arterial supply of forehead: a meta-analysis.
pmid: 39764659
abstract: The rapid growth of aesthetic medicine has led to an increased demand for non-surgical cosmetic procedures in the frontal region of the face. However, alongside this rise in popularity, there is a growing awareness of the potential complications associated with these procedures especially connected with fillers. The intricate vascular anatomy of the forehead, specifically the supratrochlear (STA) and supraorbital (SOA) arteries, poses significant risks if not thoroughly understood. While the morphological course of these vessels is well-documented and analysed, detailed knowledge about their depth remains vital for enhancing procedural safety.Five research papers were analyzed in the meta-analysis. The analyses of STA and SOA were performed in two distinctive places bilaterally: at the level of the glabella and above the eyebrow.A total of 201 SOA arteries and 282 STA arteries were analysed at the following horizontal levels, respectively: at the level of the glabella and above the eyebrow. The final results were as follows: 5.68 mm, 95% CI (4.58-6.78) for SOA at the glabella, 5.53 mm, 95% CI (4.79-6.28) for SOA above the eyebrow, 4.45 mm, 95% CI (3.43-5.47) for STA at the glabella, and 3.53 mm, 95% CI (3.21-3.85) for STA above the eyebrow.The supratrochlear artery tends to become more superficial along its path, while the supraorbital artery remains at a consistent depth across various anatomical levels. For injections in the medial part of the forehead, it is advisable to place the needle up to 2.5 mm deep or laterally to the artery's path. In contrast, injections in the lateral part of the forehead can be administered at slightly deeper depths, up to 3.5 mm. To minimise the risk of complications, performing a high-resolution linear ultrasonography (USG) exam prior to injection is recommended, allowing for needle placement either laterally or medially to the vessels.
has PII: VM/OJS/J/103774
doi: 10.5603/fm.103774
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Trzeciak M
      type: Person
      first name: Mateusz
      last name: Trzeciak
      member of: Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland. trzeciak.mateusz6@gmail.com.
  slot:
    index: 2
    item: Gładysz T
      type: Person
      first name: Tomasz
      last name: Gładysz
      member of: Department of Oral Surgery, Institute of Dentistry, Jagiellonian University Medical College, Kraków, Poland, Poland.
  slot:
    index: 3
    item: Przybycień W
      type: Person
      first name: Wojciech
      last name: Przybycień
      member of: Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
  slot:
    index: 4
    item: Bartoszcze J
      type: Person
      first name: Jędrzej
      last name: Bartoszcze
  slot:
    index: 5
    item: Pisarek J
      type: Person
      first name: Julia
      last name: Pisarek
  slot:
    index: 6
    item: Mordarski M
      type: Person
      first name: Michał
      last name: Mordarski
  slot:
    index: 7
    item: Iwanaga J
      type: Person
      first name: Joe
      last name: Iwanaga
      member of: Department of Anatomy, Kurume University School of Medicine, Kurume, Fukuoka, Japan.Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
  slot:
    index: 8
    item: Koziej M
      type: Person
      first name: Mateusz
      last name: Koziej
      member of: Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
  slot:
    index: 9
    item: Walocha J
      type: Person
      first name: Jerzy
      last name: Walocha
      member of: Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:12
e ISSN: 1644-3284
has issn l: 0015-5659
has NLM journal title abbreviation: Folia Morphol (Warsz)
publication name: Folia morphologica
language: eng
has national library of medicine journal id: 0374620
derived from: NLM
has place of publication: Poland
source: Folia Morphol (Warsz). 2025-01-07;():.

The elusive bipartite scaphoid: a rare congenital variant or misdiagnosed pseudoarthrosis? A proposal for novel radiological criteria.
pmid: 39764661
abstract: Variations in the development of carpal bones are uncommon, with the scaphoid bone typically forming from the fusion of the os centrale carpi and the radial chondrification center during embryogenesis. A bipartite scaphoid is a rare congenital disorder that occurs when these ossification centers fail to fuse, with a prevalence ranging from 0.1% to 0.6% in adult dissection. The differentiation between a bipartite scaphoid and pseudoarthrosis is challenging, complicating accurate diagnosis and evaluation. A 37-year-old male presented with right wrist pain following a minor fall. Physical examination revealed no visible deformity or swelling but restricted range of motion due to pain. Radiographic imaging identified a bipartite scaphoid with two distinct, similar-sized ossification centers, regular oval shape, smooth margins, and consistent cortical-to-medullary ratio, with no acute fractures or dislocations. The patient was treated conservatively with non-steroidal anti-inflammatory drugs and immobilization. Upon follow-up, the patient reported complete pain resolution and full range of motion in the wrist. This case emphasizes the unusual occurrence of a bipartite scaphoid bone in a patient experiencing wrist pain after a minor injury. It highlights the challenge of differentiating between a congenital bipartite scaphoid and post-traumatic pseudoarthrosis, underscoring the importance of considering this uncommon developmental variant when diagnosing and treating wrist pain.
has PII: VM/OJS/J/103218
doi: 10.5603/fm.103218
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Gaydarski L
      type: Person
      first name: Lyubomir
      last name: Gaydarski
      member of: Department of Anatomy, Histology and Embryology, Medical University of Sofia, Sofia, Bulgaria.
  slot:
    index: 2
    item: Mirazchiyski G
      type: Person
      first name: Georgi
      last name: Mirazchiyski
      member of: Medical University of Sofia, Sofia, Bulgaria.
  slot:
    index: 3
    item: Panev A
      type: Person
      first name: Atanas
      last name: Panev
      member of: Department of Anatomy, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  slot:
    index: 4
    item: Landzhov B
      type: Person
      first name: Boycho
      last name: Landzhov
      member of: Department of Anatomy, Histology and Embryology, Medical University of Sofia, Sofia, Bulgaria.
  slot:
    index: 5
    item: Piagkou M
      type: Person
      first name: Maria
      last name: Piagkou
      member of: Department of Anatomy, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  slot:
    index: 6
    item: Triantafyllou G
      type: Person
      first name: George
      last name: Triantafyllou
      member of: Department of Anatomy, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  slot:
    index: 7
    item: Olewnik Ł
      type: Person
      first name: Łukasz
      last name: Olewnik
      member of: Department of Clinical Anatomy, Masovian Academy in Plock, Płock, Poland.
  slot:
    index: 8
    item: Georgiev GP
      type: Person
      first name: Georgi P
      last name: Georgiev
      member of: Department of Orthopedics and Traumatology, University Hospital Queen Giovanna-ISUL, Medical University of Sofia, Sofia, Bulgaria. georgievgp@yahoo.com.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:12
e ISSN: 1644-3284
has issn l: 0015-5659
has NLM journal title abbreviation: Folia Morphol (Warsz)
publication name: Folia morphologica
language: eng
has national library of medicine journal id: 0374620
derived from: NLM
has place of publication: Poland
source: Folia Morphol (Warsz). 2025-01-07;():.

Mechanisms of Autophagy in Ineffective Reperfusion After Ischemic Stroke.
pmid: 39764666
abstract: Despite significant advancements in achieving high recanalization rates (80%-90%) for large vessel occlusions through mechanical thrombectomy, the issue of futile recanalization remains a major clinical challenge. Futile recanalization occurs when over half of patients fail to experience expected symptom improvement after vessel recanalization, often resulting in severe functional impairment or death. Traditionally, this phenomenon has been attributed to inadequate blood flow and reperfusion injury. More recently, ongoing neuronal death after reperfusion, which leads to the progression of the ischemic penumbra into the core infarct, has been termed futile reperfusion. This review explores the complex role of autophagy mechanisms in futile reperfusion following ischemic stroke, with a focus on its relationship to neuronal survival. We also examine the regulation of autophagic activity by epigenetic mechanisms. By investigating autophagy's role in ischemic stroke, we aim to identify novel pathways for precision treatment.
rights: © 2025 Wiley Periodicals LLC.
doi: 10.1002/jnr.70017
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Bai S
      type: Person
      first name: Shangying
      last name: Bai
      member of: Luhe Institute of Neuroscience, Capital Medical University, Beijing, China.Department of Neurology and Stroke Intervention and Translational Center (SITC), Beijing Luhe Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 2
    item: Ding Y
      type: Person
      first name: Yuchuan
      last name: Ding
      member of: Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
  slot:
    index: 3
    item: Simo L
      type: Person
      first name: Leticia
      last name: Simo
      member of: Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
  slot:
    index: 4
    item: Li F
      type: Person
      first name: Fengwu
      last name: Li
      member of: Luhe Institute of Neuroscience, Capital Medical University, Beijing, China.Department of Neurology and Stroke Intervention and Translational Center (SITC), Beijing Luhe Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 5
    item: Geng X
      type: Person
      first name: Xiaokun
      last name: Geng
      member of: Luhe Institute of Neuroscience, Capital Medical University, Beijing, China.Department of Neurology and Stroke Intervention and Translational Center (SITC), Beijing Luhe Hospital, Capital Medical University, Beijing, China.Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T05:13
e ISSN: 1097-4547
has issn l: 0360-4012
issue: 1
has NLM journal title abbreviation: J Neurosci Res
publication name: Journal of neuroscience research
language: eng
has national library of medicine journal id: 7600111
derived from: NLM
pg: e70017
has place of publication: United States
has primary subject term: D001343Q000502
has primary subject term: D000083242Q000473Q000628Q000503
has subject term: D006801
has subject term: D000818
has subject term: D015427
has subject term: D002545Q000628Q000473Q000503
has subject term: D015424Q000379
has subject term: D009474Q000473
source: J Neurosci Res. 2025-01;103(1):e70017.
volume: 103

Effects of miRNAs in inborn error of metabolism and treatment strategies.
pmid: 39764669
abstract: Metabolism is the name given to all of the chemical reactions in the cell involving thousands of proteins, including enzymes, receptors, and transporters. Inborn errors of metabolism (IEM) are caused by defects in the production and breakdown of proteins, fats, and carbohydrates. Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules, ⁓19-25 nucleotides long, hairpin-shaped, produced from DNA. They play key roles in regulating gene expression of target mRNAs at both transcriptional and post-transcriptional levels. Altered expression of miRNAs has emerged as an additional molecular mechanism implicated in the pathogenesis of many diseases, this altered miRNA expression is also present in inherited metabolic diseases. A single miRNA can regulate targets associated with similar cellular processes and pathways, making miRNAs powerful therapeutics to restore the impaired cellular functions seen in disease phenotypes by enhancing the cellular response. Although the miRNA research field has advanced significantly in recent years, studies in IEM are still limited. Further research on miRNA expression specifically related to IEM may allow the identification of new biomarkers for the diagnosis, progression, and prognosis of diseases. In this review, the literature studies between miRNAs and IEMs, diagnosis, prognosis, follow-up, and treatment possibilities of miRNAs were analyzed. We present recent advances on miRNAs in IEM and an overview of current miRNA therapeutics for the clinic.
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of Fellowship of Postgraduate Medicine.
has PII: 7944094
doi: 10.1093/postmj/qgae201
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Bayrak H
      type: Person
      first name: Harun
      last name: Bayrak
      member of: Department of Molecular Medicine, Graduate School of Health Sciences, TOBB University of Economics and Technology, Ankara 06510, Turkey.
  slot:
    index: 2
    item: Sharafi P
      type: Person
      first name: Parisa
      last name: Sharafi
      member of: Department of Medical Biology and Genetics, Faculty of Medicine, TOBB University of Economics and Technology, Ankara 06510, Turkey.
  slot:
    index: 3
    item: Özketen AÇ
      type: Person
      first name: Ahmet Ç
      last name: Özketen
      member of: DESAM Research Institute, Near East University, Nicosia 99138, Cyprus.
  slot:
    index: 4
    item: Kılıç M
      type: Person
      first name: Mustafa
      last name: Kılıç
      member of: Department of Pediatric Metabolic Diseases, University of Health Sciences, Ankara Etlik City Hospital, Ankara 06170, Turkey.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:13
e ISSN: 1469-0756
has issn l: 0032-5473
has NLM journal title abbreviation: Postgrad Med J
publication name: Postgraduate medical journal
language: eng
has national library of medicine journal id: 0234135
derived from: NLM
has place of publication: England
source: Postgrad Med J. 2025-01-07;():.

Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study.
pmid: 39764672
abstract: Cellular metabolism is inextricably linked to transmembrane levels of proton (H+), sodium (Na+), and potassium (K+) ions. Although reduced sodium-potassium pump (Na+-K+ ATPase) activity in tumors directly disturbs transmembrane Na+ and K+ levels, this dysfunction is a result of upregulated aerobic glycolysis generating excessive cytosolic H+ (and lactate) which are extruded to acidify the interstitial space. These oncogene-directed metabolic changes, affecting intracellular Na+ and H+, can be further exacerbated by upregulation of ion exchangers/transporters. As Na+/H+ imbalances impact tumor invasion, chromosomal rearrangements, proliferation rate, angiogenesis, and immune function, measuring interstitial H+ (H+ o) or pH (pHo) and interstitial Na+ (Na+ o) could provide unique insights into cancer hallmarks. We obtained proton (1H) and sodium (23Na) magnetic resonance spectroscopic imaging (MRSI) data to map pHo and Na+ o in a human-derived glioblastoma model (U87) in vivo with sorafenib (protein kinase inhibitor) treatment and a placebo. In U87 tumors, sorafenib slowed tumor growth compared to placebo and restored transmembrane H+ and Na+ levels. Placebo tumors maintained an interstitial space that was less salty and more acidic, similar to naive U87 tumors, implying a proliferative state. However, sorafenib-treated tumors had interstitial space that became more salty and less acidic, comparable to normal tissue. Importantly, these interstitial ionic changes occurred prior to tumor growth changes. These results imply that glioblastoma therapies, which may perturb transmembrane ions by different mechanisms (e.g., ion pumping, exchange, and/or transport), can be tracked by merging 1H with 23Na MRSI to measure treatment effectiveness.
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1002/nbm.5319
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Khan MH
      type: Person
      first name: Muhammad H
      last name: Khan
      member of: Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
  slot:
    index: 2
    item: Walsh JJ
      type: Person
      first name: John J
      last name: Walsh
      member of: Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
  slot:
    index: 3
    item: Kurdi S
      type: Person
      first name: Sara
      last name: Kurdi
      member of: Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
  slot:
    index: 4
    item: Mishra SK
      type: Person
      first name: Sandeep Kumar
      last name: Mishra
      member of: Department of Radiology & Biomedical Imaging, 300 Cedar St, Yale University, New Haven, Connecticut, USA.
  slot:
    index: 5
    item: Mihailović JM
      type: Person
      first name: Jelena M
      last name: Mihailović
      member of: Department of Radiology & Biomedical Imaging, 300 Cedar St, Yale University, New Haven, Connecticut, USA.
  slot:
    index: 6
    item: Coman D
      type: Person
      first name: Daniel
      last name: Coman
      member of: Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.Department of Radiology & Biomedical Imaging, 300 Cedar St, Yale University, New Haven, Connecticut, USA.
  slot:
    index: 7
    item: Hyder F
      type: Person
      first name: Fahmeed
      last name: Hyder
      member of: Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.Department of Radiology & Biomedical Imaging, 300 Cedar St, Yale University, New Haven, Connecticut, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-02
dp: 2025 Feb
created: 2025-1-7T05:13
e ISSN: 1099-1492
has issn l: 0952-3480
issue: 2
has NLM journal title abbreviation: NMR Biomed
publication name: NMR in biomedicine
language: eng
has national library of medicine journal id: 8915233
derived from: NLM
pg: e5319
has place of publication: England
has primary subject term: D000077157Q000494Q000627
has primary subject term: D059016Q000187
has primary subject term: D012964Q000378
has primary subject term: D011522
has subject term: D006801
has subject term: D000818
has subject term: D045744
has subject term: D008819
has subject term: D006863
has subject term: D009682
has subject term: D066244
has subject term: D009536Q000031Q000494Q000627
has subject term: D012975Q000378
has subject term: D010671Q000494Q000627
source: NMR Biomed. 2025-02;38(2):e5319.
volume: 38

A Soft Robotic Sleeve for Physiotherapy: Improving Elbow Rehabilitation in Baseball Pitchers.
pmid: 39764679
abstract: Throwing a baseball involves intense exposure of the arm to high speeds and powerful forces, which contributes to an increasing prevalence of arm injuries among athletes. Traditional rigid exoskeletons and rehabilitation equipment frequently lack portability, safety, ergonomic design, and affordability. Traditional rehabilitation approaches frequently require therapist monitoring, resulting in therapy delays. This paper describes a Pneumatic Artificial Muscle (PAM) based soft robotic sleeve designed for upper limb rehabilitation, with an emphasis on elbow flexion and extension in baseball pitchers.The experiment included five healthy male baseball pitchers aged 20-24 with no history of upper limb injuries, ensuring their suitability for testing the effectiveness of the PAM-based sleeve in supporting elbow flexion and extension specific to baseball pitching. The effectiveness of the PAM-based soft sleeve was evaluated utilizing a pre-post design that included surface electromyography (sEMG). Participants were tested for muscle activation and range of motion both with and without the device. The sleeve has two operational modes: Active Surge Flex Mode, which detects movement intention using sEMG and delivers targeted help, and Steady Passive Mode, which allows repetitive flexion and extension without intentional muscle activation.The PAM-based sleeve reduced muscle activation in both triceps and biceps, with reductions of approximately 40% (p < 0.05) and 60% (p < 0.05), respectively. When activated based on assistance thresholds, triceps and biceps EMG amplitudes were further reduced by 30% (p < 0.05) and 50% (p < 0.05), respectively. The flexion angle remained consistent between 70 and 90°, indicating smooth and controlled movements. The Co-Contraction Index (CCI) decreased from 0.31 to 0.12, highlighting a reduction in unnecessary muscle co-activation, thereby improving movement efficiency.The PAM-based soft robotic sleeve provides a convenient and effective upper l[cell cut: 2392 characters, first 2000 kept]
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1002/pri.70025
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Khan MUA
      type: Person
      first name: Muhammad Umair Ahmad
      last name: Khan
      member of: Department of Biomedical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.
  slot:
    index: 2
    item: Ajmal HMS
      type: Person
      first name: Hafiz Muhammad Salman
      last name: Ajmal
      member of: Department of Biomedical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.Department of Electrical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.
  slot:
    index: 3
    item: Hassan HA
      type: Person
      first name: Hashir Ali
      last name: Hassan
      member of: Department of Biomedical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.
  slot:
    index: 4
    item: Azam A
      type: Person
      first name: Areesha
      last name: Azam
      member of: Department of Biomedical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.
  slot:
    index: 5
    item: Malik E
      type: Person
      first name: Eshaal
      last name: Malik
      member of: Department of Biomedical Engineering, University of Engineering and Technology (UET) Lahore, Narowal Campus, Narowal, Pakistan.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T05:13
e ISSN: 1471-2865
has issn l: 1358-2267
issue: 1
has NLM journal title abbreviation: Physiother Res Int
publication name: Physiotherapy research international : the journal for researchers and clinicians in physical therapy
language: eng
has national library of medicine journal id: 9612022
derived from: NLM
pg: e70025
has place of publication: United States
has primary subject term: D001484Q000293Q000502
has primary subject term: D016059Q000502
has primary subject term: D012371
has primary subject term: D004576
has primary subject term: D026741
has subject term: D006801
has subject term: D008297
has subject term: D055815
has subject term: D004551Q000502
has subject term: D004867
has subject term: D018482Q000502
has subject term: http://id.nlm.nih.gov/mesh/D000067190
source: Physiother Res Int. 2025-01;30(1):e70025.
volume: 30

Methodological description of knowledge translation: Implementation of clinical practice guidelines into clinical practice.
pmid: 39764692
abstract: This methodological paper explores the intricacies of implementing evidence-based medicine in the health care sector specifically focusing on the clinical practice guideline (CPG) published by the American Physical Therapy Association's Academy of Oncologic Physical Therapy for diagnosing upper quadrant lymphedema secondary to cancer (diagnosis CPG). Although CPGs are widely available, their implementation into clinical practice remains inconsistent, slow, and complex. To address this challenge, this paper employs the Knowledge-to-Action framework, offering a detailed description of the seven stages through the lens of an in-progress case study on the implementation of the diagnosis CPG. This paper underscores the important role of knowledge translation in identifying both barriers and facilitators to effective CPG implementation. Through targeted strategies, such as stakeholder engagement and adaptation of interventions, this paper offers a framework for aligning clinical practice with evidence-based recommendations to improve overall workflow and improved patient outcomes.
rights: © 2025 American Academy of Physical Medicine and Rehabilitation.
doi: 10.1002/pmrj.13304
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Campione E
      type: Person
      first name: Elizabeth
      last name: Campione
      member of: Board Certified Clinical Specialist in Oncological Physical Therapy, LANA Certified Lymphedema Therapist, Midwestern University, Physical Therapy Program, Downers Grove, Illinois, USA.
  slot:
    index: 2
    item: Wampler M
      type: Person
      first name: Meredith
      last name: Wampler
      member of: Board Certified Clinical Specialist in Oncological Physical Therapy, Oregon State University-Cascades, Program in Physical Therapy, Bend, Oregon, USA.
  slot:
    index: 3
    item: Newell A
      type: Person
      first name: Alaina
      last name: Newell
      member of: Board Certified Clinical Specialist in Oncological Physical Therapy, Board Certified Clinical Specialist in Women's Health Physical Therapy, LANA Certified Lymphedema Therapist, Select Medical, ReVital Cancer Rehabilitation, Mechanicsburg, Pennsylvania, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:23
e ISSN: 1934-1563
has issn l: 1934-1482
has NLM journal title abbreviation: PM R
publication name: PM & R : the journal of injury, function, and rehabilitation
language: eng
has national library of medicine journal id: 101491319
derived from: NLM
has place of publication: United States
source: PM R. 2025-01-07;():.

Changes in upper airway airflow after rapid maxillary expansion considering normal craniofacial development as a factor: a retrospective study using computer fluid dynamics.
pmid: 39764702
abstract: Evidence suggests nasal airflow resistance reduces after rapid maxillary expansion (RME). However, the medium-term effects of RME on upper airway (UA) airflow characteristics when normal craniofacial development is considered are still unclear. This retrospective cohort study used computer fluid dynamics (CFD) to evaluate the medium-term changes in the UA airflow (pressure and velocity) after RME in two distinct age-based cohorts.The study included 48 subjects who underwent RME divided into two cohorts: a 6-9-year-old group (EEG group: early expansion group - 25 subjects) and an 11-14-year-old group (LEG group: late expansion group - 23 subjects). The nasal cavity and pharyngeal anatomy were segmented from Cone-beam computed tomography reconstructions taken before RME (T0) and 12 after RME (T1). The two UA airflow variables (pressure and velocity) were simulated using CFD. The maxillary expansion (PW) amount, two cross-sectional area measurements (CS1 = anterior cross-section and CS2 = posterior cross-section), and four UAs' subregions (NC = nasal cavity, PAtotal = pharyngeal airway, NP = nasopharynx, VP = velopharynx, and OP = Oropharynx) were also considered. All data were statistically analyzed.At the baseline, the airflow pressure, velocity, and noted obstructions were significantly higher in the EEG compared to LEG. At T1, there was a significant improvement in the median airway parameters in both groups, which was remarkably greater in the EEG. A significant negative correlation was found between pressure/velocity and both CS2 and NP. According to the CFD plots, the airflow pressure and velocity changes could be attributed to the reduction of the adenotonsillar tissues' sizes, which were remarkably more marked in the EEG.The results of this study cannot be generalized since they referred to a retrospective orthodontic sample without obstructive adenotonsillar hypertrophy.Twelve months after RME, normal craniofacial developmental changes and spontaneous adenoto[cell cut: 2110 characters, first 2000 kept]
rights: © The Author(s) 2025. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7944532
doi: 10.1093/ejo/cjae077
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lo Giudice A
      type: Person
      first name: Antonino
      last name: Lo Giudice
      member of: Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
  slot:
    index: 2
    item: Polizzi A
      type: Person
      first name: Alessandro
      last name: Polizzi
      member of: Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
  slot:
    index: 3
    item: Lagravere M
      type: Person
      first name: Manuel
      last name: Lagravere
      member of: Orthodontic Graduate Program, University of Alberta, Edmonton Clinic Health Academy, 11405 - 87 Avenue NW, AB, Canada.
  slot:
    index: 4
    item: Flores-Mir C
      type: Person
      first name: Carlos
      last name: Flores-Mir
      member of: Orthodontic Graduate Program, University of Alberta, Edmonton Clinic Health Academy, 11405 - 87 Avenue NW, AB, Canada.
  slot:
    index: 5
    item: Isola G
      type: Person
      first name: Gaetano
      last name: Isola
      member of: Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
  slot:
    index: 6
    item: Ronsivalle V
      type: Person
      first name: Vincenzo
      last name: Ronsivalle
      member of: Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
  slot:
    index: 7
    item: Leonardi R
      type: Person
      first name: Rosalia
      last name: Leonardi
      member of: Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2024-12-04
dp: 2024 Dec 04
created: 2025-1-7T05:33
e ISSN: 1460-2210
has issn l: 0141-5387
issue: 1
has NLM journal title abbreviation: Eur J Orthod
publication name: European journal of orthodontics
language: eng
has national library of medicine journal id: 7909010
derived from: NLM
has place of publication: England
has primary subject term: D010155
has primary subject term: D057446
has primary subject term: D010614Q000000981
has primary subject term: D009296Q000000981Q000502
has primary subject term: D054893Q000379
has primary subject term: D000403Q000502
has subject term: D006801
has subject term: D012189
has subject term: D002648
has subject term: D005260
has subject term: D008297
has subject term: D000293
has subject term: D008445
source: Eur J Orthod. 2024-12-04;47(1):.
volume: 47

The FEBS Journal in 2025: in all science, error precedes the truth.
pmid: 39764703
abstract: The FEBS Journal publishes primary papers as well as reviews in the molecular life sciences relating to the molecules and mechanisms underpinning biological processes. Editor-in-Chief Seamus Martin shares some thoughts on the nature of conducting research, some highlights of the past year at the journal, and what is in store for 2025.
rights: © 2025 Federation of European Biochemical Societies.
doi: 10.1111/febs.17392
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Martin SJ
      type: Person
      first name: Seamus J
      last name: Martin
      member of: The FEBS Journal Editorial Office, Cambridge, UK.Department of Genetics, Trinity College, Dublin 2, Ireland.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T05:33
e ISSN: 1742-4658
has issn l: 1742-464X
issue: 1
has NLM journal title abbreviation: FEBS J
publication name: The FEBS journal
language: eng
has national library of medicine journal id: 101229646
derived from: NLM
starting page: 5
ending page: 10
has place of publication: England
has primary subject term: D010506
has subject term: D006801
has subject term: D011643
source: FEBS J. 2025-01;292(1):5-10.
volume: 292

A bulb in the heart: a rupture of the non-coronary Valsalva sinus aneurysm into the atrial septum.
pmid: 39764713
has PII: 7944697
doi: 10.1093/ehjci/jeaf004
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wang Z
      type: Person
      first name: Zhao
      last name: Wang
      member of: Department of Ultrasound, Nanchong Central Hospital, Nanchong, Sichuan Province, People's Republic of China.
  slot:
    index: 2
    item: Wu J
      type: Person
      first name: Jialong
      last name: Wu
      member of: Department of Radiology, Nanchong Central Hospital, Nanchong, Sichuan Province, People's Republic of China.
  slot:
    index: 3
    item: Li Y
      type: Person
      first name: Yanhua
      last name: Li
      member of: Department of Ultrasound, Nanchong Central Hospital, Nanchong, Sichuan Province, People's Republic of China.
  slot:
    index: 4
    item: Han J
      type: Person
      first name: Jiancheng
      last name: Han
      member of: Department of Ultrasound, Nanchong Central Hospital, Nanchong, Sichuan Province, People's Republic of China.Echocardiography medical center, Beijing Anzhen Hospital,Capital Medical University. Beijing 100029, China.Beijing Key Laboratory of Maternal-Fetus Medicine in Fetal Heart Disease (BZ0308). Beijing 100029, China.
created: 2025-1-7T06:21
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:42
e ISSN: 2047-2412
has issn l: 2047-2404
has NLM journal title abbreviation: Eur Heart J Cardiovasc Imaging
publication name: European heart journal. Cardiovascular Imaging
language: eng
has national library of medicine journal id: 101573788
derived from: NLM
has place of publication: England
source: Eur Heart J Cardiovasc Imaging. 2025-01-07;():.

Oropuche Virus-An Emerging Pathogen With Escalating Risk for Outbreaks of Human Infection.
pmid: 39764714
doi: 10.1002/jmv.70155
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Brisse M
      type: Person
      first name: Morgan
      last name: Brisse
      member of: Viral Immunity and Pathogenesis Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  slot:
    index: 2
    item: Ly H
      type: Person
      first name: Hinh
      last name: Ly
      member of: Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.
created: 2025-1-7T06:23
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T05:42
e ISSN: 1096-9071
has issn l: 0146-6615
issue: 1
has NLM journal title abbreviation: J Med Virol
publication name: Journal of medical virology
language: eng
has national library of medicine journal id: 7705876
derived from: NLM
pg: e70155
has place of publication: United States
source: J Med Virol. 2025-01;97(1):e70155.
volume: 97

Preserving brain health by minimizing microplastic output from resin histology.
pmid: 39764720
abstract: With an increasing concentration of microplastics (MPs) in every biome, laboratories with a focus on creating histology slides from resin-embedded specimens could be partially responsible for expanding the emission of microscopic resinous particles into the environment. With current research elucidating harmful health impacts from MPs, releasing them incautiously is arguably unethical and, in the near future, plausibly illegal. The Orthopedic Bioengineering Research Laboratory (OBRL) is in Colorado, a state known not only for its natural beauty but also for its increasing number of legislative amendments aimed at reducing plastic pollution. The histology department of the OBRL has chosen to self-regulate due to the importance of protecting health and the environment. Because virtually every molecule of plastic ever created is still in existence, a greater need for MP research and mitigation has become apparent. Remediation is specifically important due to findings indicating negative impacts on neurodevelopment, neuronal organelle function, mental health, and the increased risk of dementia.
doi: 10.1080/01478885.2024.2449279
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Tedford T
      type: Person
      first name: Tia
      last name: Tedford
      member of: Mechanical Engineering, Orthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USA.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:53
e ISSN: 2046-0236
has issn l: 0147-8885
has NLM journal title abbreviation: J Histotechnol
publication name: Journal of histotechnology
language: eng
has national library of medicine journal id: 8003807
derived from: NLM
starting page: 1
ending page: 3
has place of publication: England
source: J Histotechnol. 2025-01-07;():1-3.

TiS2quantum dots composite carbon nanotubes aerogel with electromagnetic interference shielding effect.
pmid: 39764725
abstract: Titanium disulfide quantum dots (TiS2QDs) has garnered significant research interest due to its distinctive electronic and optical properties. However, the effectiveness of TiS2QDs in electromagnetic interference (EMI) shielding is influenced by various factors, including their size, morphology, monodispersity, tunable bandgap, Stokes shift and interfacial effects. In this study, we propose a systematic approach for the synthesis of TiS2QDs with small size (3.1 nm), uniform dispersion (∼1.5 nm), a transition from indirect to direct bandgap (bulk 0.09 eV-monolayer 0.69 eV), large Stokes shift (∼93 nm) and larger surface area containing multiple active interfaces, achieved through ultrasound-assisted liquid phase processing. Subsequently, these QDs are combined with carbon nanotubes (CNTs) to fabricate an aerogel with outstanding EMI shielding capabilities. The resulting TiS2QDs composite CNTs (C-TiS2) aerogel demonstrates robust EMI shielding of 51.9 dB within the microwave X-band (8-12.4 GHz) due to its porous and lightweight structure, effectively mitigating incoming electromagnetic (EM) radiation. Overall, this study highlights the promising properties of C-TiS2aerogel for applications in both civilian and military fields.
rights: © 2025 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
doi: 10.1088/1361-6528/ada3dc
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kong M
      type: Person
      first name: Mengnan
      last name: Kong
      member of: Institute of Nonlinear Optics, College of Science, JiuJiang University, Jiangxi 334000, People's Republic of China.College of Economics and Management, Jiangxi Polytechnic University, Jiangxi 330041, People's Republic of China.
  slot:
    index: 2
    item: Zhou L
      type: Person
      first name: Liangliang
      last name: Zhou
      member of: Institute of Nonlinear Optics, College of Science, JiuJiang University, Jiangxi 334000, People's Republic of China.
  slot:
    index: 3
    item: Chao X
      type: Person
      first name: Xingbing
      last name: Chao
      member of: Institute of Nonlinear Optics, College of Science, JiuJiang University, Jiangxi 334000, People's Republic of China.
  slot:
    index: 4
    item: Chang Z
      type: Person
      first name: Zhangyong
      last name: Chang
      member of: Institute of Nonlinear Optics, College of Science, JiuJiang University, Jiangxi 334000, People's Republic of China.
  slot:
    index: 5
    item: Wang Q
      type: Person
      first name: Qing
      last name: Wang
      member of: Institute of Nonlinear Optics, College of Science, JiuJiang University, Jiangxi 334000, People's Republic of China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:53
e ISSN: 1361-6528
has issn l: 0957-4484
issue: 10
has NLM journal title abbreviation: Nanotechnology
publication name: Nanotechnology
language: eng
has national library of medicine journal id: 101241272
derived from: NLM
has place of publication: England
source: Nanotechnology. 2025-01-07;36(10):.
volume: 36

Exploring the lived experiences of parents living with cystic fibrosis: A qualitative study.
pmid: 39764735
abstract: Because of the lengthening of their life-expectancy, more people with cystic fibrosis (CF) now pursue parenthood. To explore the experience of parenting while having CF, 18 French parents with CF were interviewed (including 12 mothers and 9 participants with a lung transplant). A thematic analysis of the interview transcripts was conducted. Within the domain of parenthood, seven themes were found: Journey to Parenthood; Experience of Parenthood; Daily Life; Administrative and Financial Aspects; Interaction of CF with Children's Lives; The Spouse; The Children. This paper documents the positive aspects of parenthood, and the logistical and emotional challenges faced by participants and how they adjust to them. Notably, this paper highlights the struggle of most participants to become parents, the sensitive period of lung transplant surgery for the family, what children are told about CF, and how children's lives are coloured by a sense of normality and worries for their sick parent.
doi: 10.1177/13591053241307874
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Jacob A
      type: Person
      first name: Anne
      last name: Jacob
      member of: Université Paris Cité, France.
  slot:
    index: 2
    item: Hubert D
      type: Person
      first name: Dominique
      last name: Hubert
      member of: Hopital Cochin, Assistance Publique des Hôpitaux de Paris, France.
  slot:
    index: 3
    item: Brain C
      type: Person
      first name: Cléa
      last name: Brain
      member of: Université Paris Cité, France.
  slot:
    index: 4
    item: Grenet D
      type: Person
      first name: Dominique
      last name: Grenet
      member of: Hôpital Foch, France.
  slot:
    index: 5
    item: Flahault C
      type: Person
      first name: Cécile
      last name: Flahault
      member of: Université Paris Cité, France.Hopital Européen George Pompidou, Assistance Publique des Hopitaux de Paris, France.Institut Gustave Roussy, France.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T05:53
e ISSN: 1461-7277
has issn l: 1359-1053
has NLM journal title abbreviation: J Health Psychol
publication name: Journal of health psychology
language: eng
has national library of medicine journal id: 9703616
derived from: NLM
pg: 13591053241307874
has place of publication: England
source: J Health Psychol. 2025-01-07;():13591053241307874.

Urgent Call for Attention to HIV-Associated Lymphoma: After AIDS 2024, the 25th International AIDS Conference.
pmid: 39764736
doi: 10.1002/jmv.70159
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Xiao Q
      type: Person
      first name: Qing
      last name: Xiao
      member of: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
  slot:
    index: 2
    item: He S
      type: Person
      first name: Sanxiu
      last name: He
      member of: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
  slot:
    index: 3
    item: Wang C
      type: Person
      first name: Chaoyu
      last name: Wang
      member of: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
  slot:
    index: 4
    item: Liu Y
      type: Person
      first name: Yi
      last name: Liu
      member of: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
  slot:
    index: 5
    item: Zhang X
      type: Person
      first name: Xiaomei
      last name: Zhang
      member of: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
  slot:
    index: 6
    item: Liu Y
      type: Person
      first name: Yao
      last name: Liu
      member of: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
created: 2025-1-7T06:22
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T05:53
e ISSN: 1096-9071
has issn l: 0146-6615
issue: 1
has NLM journal title abbreviation: J Med Virol
publication name: Journal of medical virology
language: eng
has national library of medicine journal id: 7705876
derived from: NLM
pg: e70159
has place of publication: United States
source: J Med Virol. 2025-01;97(1):e70159.
volume: 97

Typical Atrial Flutter: A Practical Review.
pmid: 39764740
abstract: Typical atrial flutter (AFL), defined as cavotricuspid isthmus (CTI)-dependent macro-re-entrant atrial tachycardia, often causes debilitating symptoms, and is associated with increased incidence of atrial fibrillation, stroke, heart failure, and death. Typical AFL occurs in patients with atrial remodeling and shares risk factors with atrial fibrillation. It is also common in patients with a history of prior heart surgery or catheter ablation. It is characterized by a recognizable ECG pattern that is highly predictive of CTI-dependent re-entry in patients without iatrogenic atrial scars. Typical AFL is difficult to manage medically due to poor efficacy of rate-controlling and antiarrhythmic drugs. Catheter ablation has been established in randomized trials to be superior to medical management in terms of safety, efficacy, and clinical outcomes including hospitalization and quality of life. Catheter ablation aims at achieving bidirectional conduction block across the CTI, which can be efficiently assessed by well-established techniques such as differential pacing. Long-term ablation success requires creating a stable transmural and continuous lesion, which can be optimized by systematic assessment of ablation parameters and lesion contiguity. The present review discusses the epidemiology, mechanisms, ECG characteristics, medical management, and catheter ablation of typical AFL.
rights: © 2025 Wiley Periodicals LLC.
doi: 10.1111/jce.16542
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Johner N
      type: Person
      first name: Nicolas
      last name: Johner
      member of: Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.
  slot:
    index: 2
    item: Namdar M
      type: Person
      first name: Mehdi
      last name: Namdar
      member of: Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.
  slot:
    index: 3
    item: Shah DC
      type: Person
      first name: Dipen C
      last name: Shah
      member of: Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T06:03
e ISSN: 1540-8167
has issn l: 1045-3873
has NLM journal title abbreviation: J Cardiovasc Electrophysiol
publication name: Journal of cardiovascular electrophysiology
language: eng
has national library of medicine journal id: 9010756
derived from: NLM
has place of publication: United States
source: J Cardiovasc Electrophysiol. 2025-01-07;():.

Estimation of Central Aortic Pressure Waveforms by Combination of a Meta-Learning Neural Network and a Physics-Driven Method.
pmid: 39764747
abstract: The accurate non-invasive detection and estimation of central aortic pressure waveforms (CAPW) are crucial for reliable treatments of cardiovascular system diseases. But the accuracy and practicality of current estimation methods need to be improved. Our study combines a meta-learning neural network and a physics-driven method to accurately estimate CAPW based on personalized physiological indicators. We collected data from 260 patients who underwent catheterization surgery, using measured CAPW and personalized physiological indicators (e.g., weight, body mass index (BMI), radial mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), radial systolic blood pressure (SBP), and radial diastolic blood pressure (DBP)) as input for neural network training. The output of the neural network are the Gaussian characteristic parameters of the single-period decomposed CAPW. The neural network model was constructed using the model-agnostic meta-learning (MAML) algorithm framework. Applying the physical characteristics of CAPW to the loss function, served to increase the constraints on the output and improve the accuracy of CAPW estimation. To verify the accuracy of the model, we compared measured and estimated CAPW in 52 patients. The results are consistent with a normalized root mean square error (NRMSE) of 0.0206. The predictions had low biases, namely SBP: 4.97 ± 4.42 mmHg, DBP: 4.78 ± 5.98 mmHg, and MAP: 0.35 ± 3.36 mmHg. The results demonstrate the accuracy and practicability of the approach to estimate CAPW. It can provide personalized parameters to calculate myocardial ischemia indicators (e.g., instantaneous wave-free ratio [iFR] and fractional flow reserve [FFR]) and may contribute to the early monitoring and prevention of cardiovascular diseases.
rights: © 2025 John Wiley & Sons Ltd.
doi: 10.1002/cnm.3905
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Sun H
      type: Person
      first name: Hao
      last name: Sun
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
  slot:
    index: 2
    item: Ma J
      type: Person
      first name: Junling
      last name: Ma
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
  slot:
    index: 3
    item: Li B
      type: Person
      first name: Bao
      last name: Li
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
  slot:
    index: 4
    item: Liu Y
      type: Person
      first name: Youjun
      last name: Liu
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
  slot:
    index: 5
    item: Liu J
      type: Person
      first name: Jincheng
      last name: Liu
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
  slot:
    index: 6
    item: Wang X
      type: Person
      first name: Xue
      last name: Wang
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
  slot:
    index: 7
    item: Baier G
      type: Person
      first name: Gerold
      last name: Baier
      member of: Cell and Developmental Biology, University College London, London, UK.
  slot:
    index: 8
    item: Liu J
      type: Person
      first name: Jian
      last name: Liu
      member of: Department of Cardiology, Peking University People's Hospital, Beijing, China.
  slot:
    index: 9
    item: Zhang L
      type: Person
      first name: Liyuan
      last name: Zhang
      member of: College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2025-01
dp: 2025 Jan
created: 2025-1-7T06:03
e ISSN: 2040-7947
has issn l: 2040-7939
issue: 1
has NLM journal title abbreviation: Int J Numer Method Biomed Eng
publication name: International journal for numerical methods in biomedical engineering
language: eng
has national library of medicine journal id: 101530293
derived from: NLM
pg: e3905
has place of publication: England
has primary subject term: D016571
has primary subject term: D062186Q000502
has primary subject term: D000465
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D001011Q000502Q000503
has subject term: D002302Q000502
has subject term: D006339Q000502
has subject term: http://id.nlm.nih.gov/mesh/D000069550
has subject term: D008875
source: Int J Numer Method Biomed Eng. 2025-01;41(1):e3905.
volume: 41

The increasing threat of vaccine-preventable diseases in Lebanon.
pmid: 39764751
doi: 10.26719/2024.30.12.810
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Porter GJ
      type: Person
      first name: George James
      last name: Porter
      member of: Population Health Sciences Institute, Newcastle University, United Kingdom.
  slot:
    index: 2
    item: Kanaan W
      type: Person
      first name: Wafaa
      last name: Kanaan
      member of: PHC Department, Ministry of Public Health, Lebanon.
  slot:
    index: 3
    item: Hamadeh R
      type: Person
      first name: Randa
      last name: Hamadeh
      member of: PHC Department, Ministry of Public Health, Lebanon.
  slot:
    index: 4
    item: Owens S
      type: Person
      first name: Stephen
      last name: Owens
      member of: Population Health Sciences Institute, Newcastle University, United Kingdom.
  slot:
    index: 5
    item: Vadi R
      type: Person
      first name: Ram
      last name: Vadi
      member of: UK-MED Risk Communication and Community Engagement, Ellen Wilkinson Building, University of Manchester, United Kingdom.
  slot:
    index: 6
    item: Maddah D
      type: Person
      first name: Diana
      last name: Maddah
      member of: Department of Public Health, Qatar University.UK-MED Risk Communication and Community Engagement, Ellen Wilkinson Building, University of Manchester, United Kingdom.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
derived from: NLM
starting page: 810
ending page: 811
has place of publication: Egypt
source: East Mediterr Health J. 2024-12-18;30(12):810-811.
volume: 30

No evidence that breast cancer occurs at higher rates among young Arab women.
pmid: 39764752
abstract: Breast cancer is often thought to occur at a younger age among Arab women based on the mean or median age at diagnosis, or the proportion of women diagnosed with breast cancer at a young age.To compare age-specific breast cancer incidence rates among women from selected Arab countries with selected high- and middle-income countries.We examined population-based, age-specific, national or regional breast cancer incidence data for 2008-2012 and 2013-2017 from Australia, Brazil, Canada, Germany, Japan, United Kingdom, and United States of America, and compared them with data from Algeria, Bahrain, Jordan, Kuwait, Morocco, Qatar, and Saudi Arabia.Breast cancer incidence among young women in the selected Arab countries was comparable to, or even lower than, the selected high- and middle-income countries. In contrast to the continued increase in rates observed in the high- and middle-income countries, the rates tended to plateau or decrease among older Arab women. Age-standardized incidence rates were lower than crude rates in the Arab countries.We found no evidence that Arab women are at higher risk of developing breast cancer at a younger age. The high number of cases among them was probably due to the younger population structure. These findings are important for refining breast cancer screening policies in the region.
rights: Copyright: © Authors 2024; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
doi: 10.26719/2024.30.12.812
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Alkhalawi E
      type: Person
      first name: Eman
      last name: Alkhalawi
      member of: Department of Family and Community Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
  slot:
    index: 2
    item: Altoukhi H
      type: Person
      first name: Huda
      last name: Altoukhi
      member of: Department of Radiology, King Abdulaziz University, Jeddah, Saudi Arabia.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
rights holder: لا دليل على إصابة النساء العربيات بسرطان الثدي في سن أصغر. إيمان الخلاوي، هدى الطوخي. لقد شاع الاعتقاد بأن النساء العربيات يتعرضن للإصابة بسرطان الثدي في سن أصغر من غيرهن، وذلك استنادًا إلى متوسط عمر المصابات في الدول العربية سجلات سريرية، بدون الأخذ في الحسبان التركيبة السكانية الشاملة. مقارنة معدلات الإصابة بسرطان الثدي بحسب السن بين نساء من بلدان عربية مختارة وبعض البلدان المرتفعة والمتوسطة الدخل. حلَّلنا بيانات سكانية محدَّدة الأعمار عن معدلات الإصابة بسرطان الثدي على المستوى الوطني أو الإقليمي في الفترة 2008-2012 والفترة 2013-2017 من أستراليا والبرازيل وكندا وألمانيا واليابان والمملكة المتحدة والولايات المتحدة الأمريكية، وقارنَّاها ببيانات من الجزائر والبحرين والأردن والكويت والمغرب وقطر والمملكة العربية السعودية. كان معدل الإصابة بسرطان الثدي بين الشابات في البلدان العربية المختارة مماثلًًا أو حتى أقل منه في البلدان المختارة ذات الدخل المرتفع والمتوسط. وعلى النقيض من الزيادة المستمرة الملحوظة في معدلات الإصابة في البلدان ذات الدخل المرتفع والمتوسط، تميل المعدلات إلى الثبات أو الانخفاض بين النساء العربيات الأكبر سًّنا. كما قد تؤثر ممارسات الكشف المبكر على هذه المعدلات. لا دليل على أن النساء العربيات أكثر عرضة لخطر الإصابة بسرطان الثدي في سن أصغر. وربما كان ارتفاع عدد الحالات بينهن راجعًًا إلى التركيبة السكانية الأصغر س اّنًّ، ولهذا تبعات مهمة في سن توصيات الكشف المبكر. Absence de preuve indiquant que le cancer du sein est plus fréquent chez les jeunes femmes arabes. Il est souvent considéré que le cancer du sein survient à un âge plus jeune chez les femmes arabes, en se basant sur l'âge moyen ou médian au moment du diagnostic, ou sur la proportion de femmes chez qui le cancer du sein a été diagnostiqué alors qu'elles étaient jeunes. Comparer les taux d'incidence du cancer du sein en fonction de l'âge chez les femmes de certains pays arabes avec ceux observés dans des pays à revenu élevé ou intermédiaire. Nous avons analysé les données nationales ou régionales sur l'incidence du cancer du sein, basées sur la population et en fonction de l'âge, pour les périodes [cell cut: 3141 characters, first 2000 kept]
derived from: NLM
starting page: 812
ending page: 820
has place of publication: Egypt
has primary subject term: D001943Q000453
has subject term: D006801
has subject term: D005260
has subject term: D015994
has subject term: D000328
has subject term: D008875
has subject term: D018912Q000706
has subject term: D000368
has subject term: D000367
has subject term: D055815
has subject term: D008877Q000453
has subject term: D014481Q000453
source: East Mediterr Health J. 2024-12-18;30(12):812-820.
volume: 30

Comparative analysis of hospital laboratory wastewater treatment techniques in Syrian Arab Republic.
pmid: 39764754
abstract: Hospital wastewater poses a significant threat to human health due to the presence of difficult-to-degrade organic compounds, active pharmaceutical ingredients and multiple inorganic substances that can pollute water resources and ecosystems.To compare the effectiveness of different techniques for removing organic load from hospital laboratory wastewater in Aleppo, Syria.We treated wastewater samples from hospital laboratories at Aleppo University Hospital, Syria, using several techniques, including biological treatment with the rotating biological contactor, adsorption with Syrian natural clay, coagulation with aluminium sulphate, advanced oxidation with ultrasound, and a combined treatment using natural clay and ultrasound. We assessed the organic load removal efficiency for each technique under different conditions.The most effective technique was the combination of natural clay and ultrasound. Applying natural clay at a concentration of 1 g/L of wastewater along with ultrasound at 40 kHz for 30 minutes achieved chemical oxygen demand and biochemical oxygen demand values suitable for irrigation, in accordance with the Syrian standard. The chemical oxygen demand value decreased to 212 mg/L with 94% removal rate, and the biochemical oxygen demand value decreased to 82 mg/L with 87% removal rate.Based on our findings, techniques that combine different methods of hospital wastewater treatment, such as combining adsorption with advanced methods like ultrasound, are more effective than those that use single methods. Such techniques should be promoted.
rights: Copyright: © Authors 2024; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
doi: 10.26719/2024.30.12.829
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Tattan A
      type: Person
      first name: Abdalrhman
      last name: Tattan
      member of: Department of Environmental Engineering, Faculty of Civil Engineering, University of Aleppo, Aleppo, Syria.
  slot:
    index: 2
    item: Jaara F
      type: Person
      first name: Fatimeh
      last name: Jaara
      member of: Department of Environmental Engineering, Faculty of Civil Engineering, University of Aleppo, Aleppo, Syria.
  slot:
    index: 3
    item: Nebghali N
      type: Person
      first name: Nowzete
      last name: Nebghali
      member of: Department of Basic Sciences, Faculty of Civil Engineering, University of Aleppo, Aleppo, Syria.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
rights holder: تحليل مقارن لتقنيات معالجة مياه الصرف الصحي لمختبرات أحد المستشفيات في الجمهورية العربية السورية. عبد الرحمن تتان، فاطمة جعارة، نوزت النبغلي. تشكل مياه الصرف الصحي الناتجة عن المستشفيات تهديدًا كبيرًا لصحة الإنسان، لاحتوائها على مركبات عضوية يصعب تحلُّلها، ومكونات صيدلانية فعَّالة، والعديد من الملوثات غير العضوية التي يمكن أن تلوث الموارد المائية والنُّظم الإيكولوجية. هدفت هذه الدراسة الى مقارنة فعالية التقنيات المختلفة لإزالة الحمل العضوي من مياه الصرف الصحي لمختبرات المستشفى في حلب، الجمهورية العربية السورية. عالجنا عينات من مياه الصرف الصحي الناتجة عن مختبرات مشفى حلب الجامعي في الجمهورية العربية السورية بعدة تقنيات، من بينها المعالجة البيولوجية بالجهاز التلامسي البيولوجي الدوار، والامتزاز بالطمي السوري الطبيعي، والتخثُّر بكبريتات الألومنيوم، والأكسدة المتقدمة بالموجات فوق الصوتية، والمعالجة المشتركة بالطمي الطبيعي والموجات فوق الصوتية، ثم قيَّمنا كفاءة كل تقنية منها في إزالة الأحمال العضوية في ظل ظروف مختلفة. كان المزج بين الطمي الطبيعي والموجات فوق الصوتية التقنية الأكثر فعالية. فقد أدَّى استخدام الطمي الطبيعي بتركيز 1 جرام/ لتر من مياه الصرف الصحي، إلى جانب الموجات فوق الصوتية بتردد 40 كيلوهرتز لمدة 30 دقيقة، إلى ظهور قِيَم مناسبة للري من مطلوبية الأكسجين الكيميائية ومطلوبية الأكسجين البيوكيميائية، وذلك وفقًا للمعيار السوري. وانخفضت قيمة مطلوبية الأكسجين الكيميائية إلى 212 مليجرام/ لتر بمعدل إزالة بلغ 94٪، وانخفضت قيمة مطلوبية الأكسجين البيوكيميائية إلى 82 مليجرام/ لتر بمعدل إزالة بلغ 87٪. استنادًا إلى نتائج البحث، توصَّلنا إلى أن التقنيات التي تجمع بين طرق مختلفة لمعالجة مياه الصرف الصحي للمستشفيات، مثل الجمع بين الامتزاز والطرق المتقدمة، كالموجات فوق الصوتية مثلًًا، أكثر فعالية من تلك التي تستخدم طريقة واحدة. وينبغي التشجيع على استخدام مثل هذه التقنيات. Analyse comparative des techniques de traitement des eaux usées dans les laboratoires hospitaliers en République arabe syrienne. Les eaux usées des hôpitaux constituent une menace importante pour la santé humaine en raison de la présence de composés organiques difficiles à dégrader, de principes actifs pharma[cell cut: 3743 characters, first 2000 kept]
derived from: NLM
starting page: 829
ending page: 836
has place of publication: Egypt
has primary subject term: D062065Q000737
has subject term: D013593
has subject term: D014865Q000379
has subject term: D006801
has subject term: D018508Q000379
source: East Mediterr Health J. 2024-12-18;30(12):829-836.
volume: 30

Prevalence of child maltreatment in Albania.
pmid: 39764753
abstract: Child maltreatment is a global issue that significantly impacts children's lives. In 2018, 32% of 15-year-olds in Albania reported experiencing physical abuse.To assess the prevalence and sociodemographic correlates of child abuse and neglect in Albania.This was the 2022 Health Behaviour in School-aged Children nationwide survey in Albania conducted among 1877 schoolchildren (55% girls) aged 15 years. We collected data on sociodemographic characteristics, physical abuse, emotional abuse, sexual abuse, emotional neglect, and exposure to domestic violence. We analysed the data using SPSS version 19.0 and used binary logistic regression to assess associations between child abuse, neglect and sociodemographic characteristics.Lifetime prevalence rates were 33.1% for physical abuse, 16.2% for emotional abuse, 3.7% for sexual abuse, 15.7% for emotional neglect, and 7.0% for witness to domestic violence. Children living in urban areas had higher odds of experiencing physical or emotional abuse (OR = 1.4 and 1.6, 95% CI = 1.1-1.7 and 1.2-2.2). Girls had higher odds of experiencing emotional abuse (OR = 1.8, 95% CI = 1.4-2.4) or emotional neglect (OR = 3.4, 95% CI = 2.5-4.6). Girls and children from less affluent families had lower odds of experiencing sexual abuse (OR = 0.6, 95% CI = 0.3-0.9; OR = 0.5, 95% CI = 0.3-0.8, respectively). Children whose fathers were unemployed had higher odds of witnessing domestic violence (OR = 1.9, 95% CI = 1.1-3.2).Abuse and neglect are highly prevalent among Albanian children aged 15 years, raising concerns over their future wellbeing. Action is needed by professionals and caregivers and at policy level to mitigate the negative impact and promote children's protection and well-being in the country.
rights: Copyright: © Authors 2024; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
doi: 10.26719/2024.30.12.821
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Dika Q
      type: Person
      first name: Qamil
      last name: Dika
      member of: Faculty of Medicine, University of Medicine, Tirana, Albania.
  slot:
    index: 2
    item: Duli M
      type: Person
      first name: Marsida
      last name: Duli
      member of: Faculty of Medicine, University of Medicine, Tirana, Albania.
  slot:
    index: 3
    item: Burazeri G
      type: Person
      first name: Genc
      last name: Burazeri
      member of: Faculty of Medicine, University of Medicine, Tirana, Albania.Department of International Health, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
  slot:
    index: 4
    item: Çumashi R
      type: Person
      first name: Rudina
      last name: Çumashi
      member of: Institute of Public Health, Tirana, Albania.
  slot:
    index: 5
    item: Hala R
      type: Person
      first name: Romina
      last name: Hala
      member of: Institute of Public Health, Tirana, Albania.
  slot:
    index: 6
    item: Agolli E
      type: Person
      first name: Elsona
      last name: Agolli
      member of: United Nations Population Fund Office in Albania.
  slot:
    index: 7
    item: Qirjako G
      type: Person
      first name: Gentiana
      last name: Qirjako
      member of: Faculty of Medicine, University of Medicine, Tirana, Albania.Institute of Public Health, Tirana, Albania.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
rights holder: انتشار إساءة معاملة الأطفال في ألبانيا. كاميل ديكا، مارسيدا دولي، جينك بورازيري، رودينا تشوماشي، رومينا هالا، إلسونا أجولي، جنتيانا كيراكو. إساءة معاملة الأطفال مشكلة عالمية لها أثر بالغ على حياتهم، وفي عام 2018، أبلغ 32٪ من الأطفال البالغين 15 عامًا في ألبانيا عن تعرضهم للاعتداء البدني. هدفت هذه الدراسة الى تقييم مدى انتشار إساءة معاملة الأطفال وإهمالهم في ألبانيا والارتباطات الاجتماعية السكانية بهما. أُجريَ في عام 2022 استقصاء السلوك الصحي للأطفال في سن الدراسة على الصعيد الوطني في ألبانيا، وشمل 1877 مشاركًا من تلاميذ المدارس الذين تبلغ أعمارهم 15 سنة (55٪ منهم فتيات). وخلال هذا الاستقصاء جمعنا بيانات عن الخصائص الاجتماعية السكانية، والاعتداء البدني، والإيذاء العاطفي، والاعتداء الجنسي، والإهمال العاطفي، والتعرض للعنف الأسري. وقد حلَّلنا البيانات بالإصدار 19.0 من برمجية SPSS، واستخدمنا الانحدار اللوجستي الثنائي لتقييم الارتباط بين إساءة معاملة الأطفال وإهمالهم والخصائص الاجتماعية السكانية. بلغت معدلات الانتشار مدى الحياة 33.1٪ للاعتداء البدني، و16.2٪ للإيذاء العاطفي، و3.7٪ للاعتداء الجنسي، و15.7٪ للإهمال العاطفي، وكان 7٪ شهداء على حالات عنف أسري. وكان احتمال التعرض للاعتداء البدني أو الإيذاء العاطفي أكبر لدى الأطفال الذين يعيشون في مناطق حضرية (نسبة الأرجحية = 1.4 و1.6، بينما كان فاصل الثقة 95٪ = 1.1–1.7، و1.2–2.2). وكان احتمال تعرُّض الفتيات للإيذاء العاطفي (نسبة الأرجحية = 1.8، فاصل الثقة 95٪ = 1.4–2.4) أو الإهمال العاطفي (نسبة الأرجحية = 3.4، فاصل الثقة 95٪ = 2.5–4.6) أعلى. أمَّا الاعتداء الجنسي فقد كانت احتمالية التعرض له أعلى بين الفتيان والأطفال من الأُسر الثرية (نسبة الأرجحية = 0.6، فاصل الثقة 95٪ = 0.3–0.9؛ نسبة الأرجحية = 0.5، فاصل الثقة 95٪ = 0.3–0.8، على التوالي). وكان احتمال التعرض للعنف الأسري أكبر بين الأطفال الذين كان آباؤهم عاطلين عن العمل (نسبة الأرجحية = 1.9، فاصل الثقة 95٪ = 1.1–3.2). تنتشر الإساءة والإهمال انتشارًا كبيرًا بين الأطفال الألبانيين في عمر 15 عامًا، وهو ما يثير المخاوف والقلق بشأن عافيتهم في المستقبل. ويجب اتخاذ الإجراءات اللازمة من جانب المهنيين والقائمين على الرعاية، وعلى مستوى السياسات، للتخفيف من الأثر السلبي للمشكلة وتعزيز حماية[cell cut: 4418 characters, first 2000 kept]
derived from: NLM
starting page: 821
ending page: 828
has place of publication: Egypt
has primary subject term: D002649Q000706
has subject term: D006801
has subject term: D000415Q000453
has subject term: D005260
has subject term: D008297
has subject term: D015995
has subject term: D000293
has subject term: D012959
has subject term: http://id.nlm.nih.gov/mesh/D000091569
has subject term: D002648
has subject term: D003430
has subject term: D017579Q000706
source: East Mediterr Health J. 2024-12-18;30(12):821-828.
volume: 30

Beyond illness: Understanding the social determinants in the life of a middle-aged Pakistani woman.
pmid: 39764756
abstract: Poverty is both a cause and a consequence of poor health, and the scarcity of resources limits access to essential health care services.To highlight the implications on health of the often-neglected social determinants.We examined the experiences of Shahida Parveen, a middle-aged, unmarried woman, living in a resource-poor setting in Rawalpindi, Pakistan, and the interplay of the social determinants and inadequate safety nets on her health and wellbeing.Shahida's narrative unveiled a poignant journey marked by health challenges early in her lifetime, her profound losses and the systemic barriers to accessing healthcare. Poverty, limited social support, and healthcare disparities emerged as central factors in shaping her health outcomes.This case report highlights the need for a more just and more inclusive healthcare system that guarantees comprehensive social safety nets and accessible health care services for vulnerable populations.
rights: Copyright: © Authors 2024; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
doi: 10.26719/2024.30.12.847
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Abdullah MA
      type: Person
      first name: Muhammad Ahmed
      last name: Abdullah
      member of: Health Services Academy, Islamabad.
  slot:
    index: 2
    item: Shaikh BT
      type: Person
      first name: Babar Tasneem
      last name: Shaikh
      member of: Health Services Academy, Islamabad.
  slot:
    index: 3
    item: Sattar NY
      type: Person
      first name: Nargis Yousuf
      last name: Sattar
      member of: Central Institute of Family Medicine, Islamabad.
  slot:
    index: 4
    item: Gillani SM
      type: Person
      first name: Syed Mujahid
      last name: Gillani
      member of: Islamabad Medical and Dental College, Islamabad.
  slot:
    index: 5
    item: Ahmed AS
      type: Person
      first name: Ameer Sikander
      last name: Ahmed
      member of: Islamabad Medical and Dental College, Islamabad.
  slot:
    index: 6
    item: Shaikh WQ
      type: Person
      first name: Waleed Qaisar
      last name: Shaikh
      member of: National University of Medical Sciences, Rawalpindi.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
rights holder: ما بعد الاعتلال: فهم أثر المُحدِّدات الاجتماعية في حياة امرأة باكستانية في منتصف العمر. محمد أحمد عبد الله، بابر تسنيم شيخ، نرگس یوسف ستار، سید مجاهد كيلاني، أمير إسكندر أحمد، ولید قيصر شيخ. الفقر سبب من أسباب اعتلال الصحة ونتيجة له، وتساهم ندرة الموارد في الحد من إمكانية الحصول على خدمات الرعاية الصحية الأساسية. هدفت هذه الدراسة الى تسليط الضوء على آثار المحدِّدات الاجتماعية التي غالبًا ما يجري إغفالها على الصحة. درسنا التجارب التي مرت بها شهيدة بارفين، وهي امرأة في منتصف العمر وغير متزوجة، تعيش في بيئة فقيرة الموارد في راولبندي بباكستان، وبحثنا في أثر المُحدِّدات الاجتماعية وعدم كفاية شبكات الأمان على صحتها وعافيتها. كشفت حكاية شهيدة عن رحلتها المُثيرة للأسى بعد أن تعرضت في بداية حياتها لتحديات صحية، فضلًًا عن خسائرها الكبيرة، وعقبات النظام التي تحول دون حصولها على الرعاية الصحية. وتبين أن الفقر وقلة الدعم المجتمعي وتفاوتات الرعاية الصحية عوامل رئيسية في تشكيل حصائلها الصحية. يسلط تقرير الحالة هذا الضوء على الحاجة إلى نظام رعاية صحية أكثر عدلًًا وشمولًًا يضمن توفير شبكات أمان اجتماعي شاملة، وإتاحة خدمات الرعاية الصحية للفئات السكانية المُستضعفة. Au-delà de la maladie : comprendre les déterminants sociaux dans la vie d'une femme d'âge moyen au Pakistan. La pauvreté est à la fois une cause et une conséquence de la mauvaise santé, et la pénurie de ressources limite l'accès aux services de soins de santé essentiels. Mettre en évidence les implications des déterminants sociaux pour la santé, qui sont souvent négligés. Nous avons examiné les expériences de Shahida Parveen, une femme célibataire d'âge moyen vivant dans un milieu défavorisé à Rawalpindi (Pakistan), ainsi que l'interaction des déterminants sociaux et de l'insuffisance des filets de sécurité sur sa santé et son bien-être. Le récit de Shahida a dévoilé un parcours poignant marqué par des problèmes de santé survenus au début de sa vie, des pertes tragiques et des obstacles systémiques à l'accès aux soins de santé. La pauvreté, le soutien social limité et les disparités en matière de soins de santé sont apparu[cell cut: 2358 characters, first 2000 kept]
derived from: NLM
starting page: 847
ending page: 850
has place of publication: Egypt
has primary subject term: D006297
has primary subject term: D011203
has primary subject term: D064890
has subject term: D005260
has subject term: D006801
has subject term: D008875
has subject term: D054625
has subject term: D010154
has subject term: D012944
source: East Mediterr Health J. 2024-12-18;30(12):847-850.
volume: 30

Exploring food safety knowledge and practices in Lebanon.
pmid: 39764755
abstract: Lebanon's economic and financial crises have affected the quality-of-life, including food safety and food security.To assess food safety knowledge and practices among a sample Lebanese population and the association with the sociodemographic and economic characteristics of participants.This cross-sectional study collected data online from 412 Lebanese adults aged ≥ 18 years [mostly female (77.7%)] between October and December 2021. The data included their sociodemographic characteristics, food safety knowledge and practices, experience of food insecurity, and financial wellbeing. We conducted logistic regression analyses to explore the associations between food safety knowledge and practices, sociodemographic variables, and food security status of participants.A significantly higher proportion of married (vs single) participants said they reheated refrigerated meat or chicken before consumption (74.3% vs 63.1%, P = 0.017). A significantly higher proportion of participants in the higher income category and those with university education (versus lower level of education) knew the characteristics of a contaminated food (34.2% vs 15.0%, P = 0.008). Older participants were significantly more knowledgeable about the management of leftover food (mean 34.54 years vs 31.25 years; P = 0.014). Household food security status did not show any statistically significant association with any of the 5 food safety measures examined.This study confirms the existence of suboptimal food safety knowledge and practices by almost half of the sample. There is therefore a need for evidence-based public health interventions to increase knowledge, and promote better practices, of safe food handling, thereby reducing the risk of foodborne diseases in Lebanon.
rights: Copyright: © Authors 2024; Licensee: World Health Organization. EMHJ is an open access journal. All papers published in EMHJ are available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
doi: 10.26719/2024.30.12.837
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Karam J
      type: Person
      first name: Joanne
      last name: Karam
      member of: Institut National de Santé Publique, d'Épidémiologie Clinique et de Toxicologie-Liban, Beirut, Lebanon.Department of Nutritional Sciences, Faculty of Health Sciences, University of Balamand, Koura, Lebanon.
  slot:
    index: 2
    item: Serhan M
      type: Person
      first name: Mireille
      last name: Serhan
      member of: Department of Nutritional Sciences, Faculty of Health Sciences, University of Balamand, Koura, Lebanon.
  slot:
    index: 3
    item: Haddad C
      type: Person
      first name: Chadia
      last name: Haddad
      member of: Institut National de Santé Publique, d'Épidémiologie Clinique et de Toxicologie-Liban, Beirut, Lebanon.School of Health Sciences, Modern University of Business and Science, Beirut, Lebanon.Research Department, Psychiatric Hospital of the Cross, Beirut, Lebanon.Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon.
  slot:
    index: 4
    item: Sacre H
      type: Person
      first name: Hala
      last name: Sacre
      member of: Institut National de Santé Publique, d'Épidémiologie Clinique et de Toxicologie-Liban, Beirut, Lebanon.
  slot:
    index: 5
    item: Jomaa L
      type: Person
      first name: Lamis
      last name: Jomaa
      member of: Department of Nutrition, Gillings School of Global Public Health, University of North Carolina Chapel Hill, United States of America.Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon.
  slot:
    index: 6
    item: Salameh P
      type: Person
      first name: Pascale
      last name: Salameh
      member of: Institut National de Santé Publique, d'Épidémiologie Clinique et de Toxicologie-Liban, Beirut, Lebanon.Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon.Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus.Faculty of Pharmacy, Lebanese University, Hadath, Lebanon.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
rights holder: إستكشاف مدى الدراية بسلامة الأغذية وممارساتها في لبنان. جوان كرم، ميراي سرحان، شادية حداد، هالة صقر، لميس جمعة، باسكال سلامة. تركت الأزمات الاقتصادية والمالية في لبنان أثرها على جودة الحياة فيه، ويشمل ذلك سلامة الأغذية والأمن الغذائي. هدفت هذه الدراسة الى تقييم مدى الدراية بسلامة الأغذية والممارسات المتعلقة بها بين عينة من السكان اللبنانيين، وارتباط ذلك بالسمات الأخرى لهم :(العمرية، الجندرية، التعلمية، الحالة الإجتماعية ، الوضع الإقتصادي). جمعت هذه الدراسة المقطعية بيانات عبر الإنترنت عن العينة البالغ عددها (412)من اللبنانيين البالغين ، أعمارهم من (18) عام وما فوق، [معظمهم من الإناث (77.7٪)] في الفترة بين أكتوبر/ تشرين الأول وديسمبر/ كانون الأول عام (2021). وتضمّنت البيانات الخصائص الاجتماعية السكانية للمشاركين، ومعلوماتهم عن سلامة الأغذية وممارساتها، وتجاربهم مع التعرض لانعدام الأمن الغذائي، والازدهار المالي .تم إجراء تحليلات الانحدار اللوجستي لاستكشاف العلاقات بين المعرفة بممارسات سلامة الأغذية والمتغيرات الاجتماعية الديموغرافية وحالة الأمن الغذائي للمشاركين. ذكرت نسبة كبيرة إحصائيًّا من المشاركين المتزوجين (74.3٪)، مقابل (63.1٪) من غير المتزوجين ، الإحتمالية = 0.017)،أنهم أعادوا تسخين الدجاج أو اللحوم المبردة قبل تناولها.وكانت نسبة من المشاركين (34.2٪) هم من أصحاب الدخل المرتفع والحاصلين على تعليم جامعي مقابل (15.0٪) الحاصلين على مستوى تعليمي دون الجامعي (الإحتمالية= 0.008) يعرفون سمات الطعام الملوّث . أمَّا المشاركون الأكبر سنًّا فقد كانت نسبتهم أعلى من الناحية الإحصائية، فيما يتعلق بمعرفة طُرُق التعامل مع بقايا الطعام (متوسط السن 34.54 سنة مقابل 31.25 سنة؛الاحتمالية = 0.014). ولم يُظهر وضع الأمن الغذائي للأسر أي ارتباط ذي دلالة إحصائية بأي من التدابير الخمسة لسلامة الأغذية التي خضعت للدراسة. أكَّدت هذه الدراسة أن الدراية بسلامة الأغذية وممارساتها كانت دون المستوى الأمثل لدى ما يقرب من نصف العينة. ولذلك توجد حاجة إلى تدخلات صحية عامة لزيادة الوعي والتشجيع على أفضل الممارسات، فيما يتعلق بالتعامل الآمن مع الأغذية، ومن ثم الحد من خطر الأمراض المنقولة بالأغذية في لبنان. Étude des connaissances et des pratiques en matière de sécurité sanitaire des aliments au Liban. [cell cut: 4427 characters, first 2000 kept]
derived from: NLM
starting page: 837
ending page: 846
has place of publication: Egypt
has primary subject term: D059022
has primary subject term: D007722
has subject term: D006801
has subject term: D007861
has subject term: D005260
has subject term: D008297
has subject term: D003430
has subject term: D000328
has subject term: D008875
has subject term: D012959
has subject term: D055815
has subject term: D000293
has subject term: D011795
source: East Mediterr Health J. 2024-12-18;30(12):837-846.
volume: 30

Flaccid paraplegia of the lower limbs in paediatric patients has many causes.
pmid: 39764757
doi: 10.26719/2024.30.12.851
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Finsterer J
      type: Person
      first name: Josef
      last name: Finsterer
      member of: Neurology Department, Neurology and Neurophysiology Center, Vienna, Austria.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-12-18
dp: 2024 Dec 18
created: 2025-1-7T06:04
e ISSN: 1687-1634
has issn l: 1020-3397
issue: 12
has NLM journal title abbreviation: East Mediterr Health J
publication name: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
language: eng
has national library of medicine journal id: 9608387
derived from: NLM
starting page: 851
ending page: 852
has place of publication: Egypt
source: East Mediterr Health J. 2024-12-18;30(12):851-852.
volume: 30

The association between family resilience and psychological well-being during the COVID-19 pandemic: A three-level meta-analysis.
pmid: 39764762
abstract: Despite numerous studies observing a positive correlation between family resilience and psychological well-being during the COVID-19 pandemic, the strength of this association varied considerably in previous research. This study aims to obtain reliable estimates for effect sizes and investigate the potential moderators of the association between family resilience and psychological well-being during the COVID-19 pandemic. Seventeen studies (65 effect sizes, 14,511 participants) were reviewed using a systematic literature search and the PRISMA approach. A three-level meta-analysis revealed a significant positive correlation (r = 0.504, p < 0.001) between family resilience and psychological well-being during the COVID-19 pandemic. Notably, education level significantly moderated this relationship, along with the type of psychological well-being and the measures used for assessment. These findings highlight the critical role of family resilience in enhancing psychological well-being and emphasize the importance of considering educational factors in designing interventions to improve psychological outcomes during pandemics.
doi: 10.1177/13591053241311572
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Li R
      type: Person
      first name: Rui
      last name: Li
      member of: Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China.Key Laboratory of Adolescent CyberPsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
  slot:
    index: 2
    item: Wu D
      type: Person
      first name: Donghong
      last name: Wu
      member of: Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China.Key Laboratory of Adolescent CyberPsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
  slot:
    index: 3
    item: Zhu L
      type: Person
      first name: Lin
      last name: Zhu
      member of: Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China.Key Laboratory of Adolescent CyberPsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
  slot:
    index: 4
    item: Mi T
      type: Person
      first name: Tingni
      last name: Mi
      member of: Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China.Key Laboratory of Adolescent CyberPsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
  slot:
    index: 5
    item: Jia S
      type: Person
      first name: Siyao
      last name: Jia
      member of: Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China.Key Laboratory of Adolescent CyberPsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
  slot:
    index: 6
    item: Ren Z
      type: Person
      first name: Zhihong
      last name: Ren
      member of: Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan, China.Key Laboratory of Adolescent CyberPsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T06:13
e ISSN: 1461-7277
has issn l: 1359-1053
has NLM journal title abbreviation: J Health Psychol
publication name: Journal of health psychology
language: eng
has national library of medicine journal id: 9703616
derived from: NLM
pg: 13591053241311572
has place of publication: England
source: J Health Psychol. 2025-01-07;():13591053241311572.

Incongruent Expectations: A Qualitative Study of the Gendered Experiences of Canadian Young People.
pmid: 39764763
abstract: While the early mental health of girls and boys is similar, as children age, girls tend to report worse mental health than boys. Explanations for these gendered disparities remain elusive. This study seeks to understand the social context in which mental health experiences are shaped. Utilizing a qualitative, constructivist approach to grounded theory, we conducted virtual semi-structured interviews with young people between ages 11 and 17 years (n = 20). Our major finding was that girls in particular experience incongruence between expectations about gender equality and everyday experiences of stereotypes, barriers, and discrimination. Girls reported pressures to satisfy multiple gender norms, such as traditional ideals about being feminine (kind and physically attractive) and modern ideas about being high achieving and smarter than boys. Findings suggest that young people are unequipped to navigate the incongruence between the expectation that they live in a gender-equal world and their experiences of gender-based constraints, nor do they appear to have the skills to critically identify the structural patterns that undergird their experiences. Explanations for gendered disparities in mental health may be related to the underlying context of discrimination, and both traditional and emerging gendered norms, barriers, and constraints. Finally, we highlight the responsibility of adults to facilitate child development in ways that are responsive to the changing faces of gender discrimination, which readily adapts to social discourse in new and subtle ways.
doi: 10.1177/10497323241308779
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Michaelson V
      type: Person
      first name: Valerie
      last name: Michaelson
      member of: Department of Health Sciences, Brock University, St. Catharines, ON, Canada.
  slot:
    index: 2
    item: Pilato KA
      type: Person
      first name: Kelly A
      last name: Pilato
      member of: Department of Health Sciences, Brock University, St. Catharines, ON, Canada.
  slot:
    index: 3
    item: Murray J
      type: Person
      first name: Julie
      last name: Murray
      member of: Department of Criminology, University of Ottawa, Ottawa, ON, Canada.
  slot:
    index: 4
    item: McIsaac MA
      type: Person
      first name: Michael A
      last name: McIsaac
      member of: School of Mathematical and Computational Sciences, University of Prince Edward Island, Charlottetown, PE, Canada.
  slot:
    index: 5
    item: Wadge S
      type: Person
      first name: Stephanie
      last name: Wadge
      member of: Department of Health Sciences, Brock University, St. Catharines, ON, Canada.
  slot:
    index: 6
    item: Steeves V
      type: Person
      first name: Valerie
      last name: Steeves
      member of: Department of Criminology, University of Ottawa, Ottawa, ON, Canada.
creator: for our grant team writing group
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T06:13
ISSN: 1049-7323
has issn l: 1049-7323
has NLM journal title abbreviation: Qual Health Res
publication name: Qualitative health research
language: eng
has national library of medicine journal id: 9202144
derived from: NLM
pg: 10497323241308779
has place of publication: United States
source: Qual Health Res. 2025-01-07;():10497323241308779.

Clinical Profile and Management of Wolf-Parkinson White Syndrome and Asymptomatic Pre-Excitation Carriers in Africa: A Multicenter Pan African Registry From 17 Countries.
pmid: 39764766
abstract: Data are scarce regarding Wolf-Parkinson White Syndrome (WPW) syndrome and asymptomatic pre-excitation in Africa. This study tried to understand the current approaches utilized in Africa for the diagnosis and management of both symptomatic and asymptomatic ventricular pre-excitation.The current prospective study was conducted in 20 centers located in 17 countries spanning all areas of Africa. Participants included had ventricular pre-excitation patterns. The data collected included symptoms, locations of accessory pathways (AP) and tachyarrhythmia, risk stratification, as well as acute and long-term management. In addition, we assessed the clinical effectiveness of the centers and the impact of socioeconomic and health metrics on these treatment approaches.Among 541 participants, 93% were diagnosed with WPW syndrome, with orthodromic atrioventricular reciprocating tachycardia (AVRT) being the most prevalent arrhythmia, affecting 55% of the cases. Approximately 30% of patients in Africa, except for the southern region, received intravenous amiodarone as the first-choice drug for orthodromic AVRT while adenosine was the drug of choice in the Southern region. Electrical cardioversion was the first-line treatment for pre-excited atrial fibrillation and antidromic AVRT across all of Africa. Radiofrequency ablation (RF) was the first long-term therapy option for 88% of patients in all African regions, unlike western and central Africa where it was implemented for less than 30% of patients (p < 0.001). The rates of RF success, long-term recurrence, and complications were 93%, 4.1%, and 3.8%, respectively.There are significant variations between African regions in terms of diagnostic workup, accessory pathway localizations, and volume of invasive treatment. Countries in Northern and Southern Africa are more advanced than other African countries in terms of modern management strategy. Additional government investments are necessary to enhance diagnostic likelihood and curati[cell cut: 2079 characters, first 2000 kept]
rights: © 2025 Wiley Periodicals LLC.
doi: 10.1111/jce.16523
creator: OrderedList
  length: 21
  slot:
    index: 1
    item: Allam L
      type: Person
      first name: Lamyaa
      last name: Allam
      member of: Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  slot:
    index: 2
    item: Bekouti JT
      type: Person
      first name: Jean Timnou
      last name: Bekouti
      member of: Interventional Cardiology Center of Douala, Douala, Cameroon.
  slot:
    index: 3
    item: Gabra MD
      type: Person
      first name: Mohamed Diaa
      last name: Gabra
      member of: Faculty of Medicine, South Valley University, Qena, Egypt.
  slot:
    index: 4
    item: Shogade TT
      type: Person
      first name: Tolulope Taiwo
      last name: Shogade
      member of: Cardiology Unit, Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria.
  slot:
    index: 5
    item: El-Hariri HM
      type: Person
      first name: Hazem Mohamed
      last name: El-Hariri
      member of: Community Medicine Department, National Research Centre, Cairo, Egypt.
  slot:
    index: 6
    item: Seddik AMM
      type: Person
      first name: Ait Messaoudene Mohamed
      last name: Seddik
      member of: CHU Mustapha Cardiologi, Algiers, Algeria.
  slot:
    index: 7
    item: Kahled B
      type: Person
      first name: Bouasria
      last name: Kahled
      member of: CHU Mustapha, Algiers, Algeria.
  slot:
    index: 8
    item: Vezi B
      type: Person
      first name: Brian
      last name: Vezi
      member of: EThekwini Hospital, Durban, South Africa.
  slot:
    index: 9
    item: Jabeur M
      type: Person
      first name: Mariem
      last name: Jabeur
      member of: Hedi Chaker University Hospital of Sfax, Sfax, Tunisia.
  slot:
    index: 10
    item: Soulemane P
      type: Person
      first name: Pessinaba
      last name: Soulemane
      member of: Campus Teaching Hospital, Lomé, Togo.
  slot:
    index: 11
    item: Sonou A
      type: Person
      first name: Arnaud
      last name: Sonou
      member of: National Teaching Hospital Hubert Koutoukou Maga, Cotonou, Benin Republic.
  slot:
    index: 12
    item: Alison MR
      type: Person
      first name: Michael Rory
      last name: Alison
      member of: Lady Pohamba Private Hospital, Windhoek, Namibia.
  slot:
    index: 13
    item: Houchinne L
      type: Person
      first name: Lemoné
      last name: Houchinne
      member of: Clinique Maison du Coeur, N'Djaména, Chad.
  slot:
    index: 14
    item: Adjougoulta Koboy AA
      type: Person
      first name: Allah-Amine
      last name: Adjougoulta Koboy
      member of: CHU la Référence Nationale, N'Djaména, Chad.
  slot:
    index: 15
    item: Roberto J
      type: Person
      first name: José
      last name: Roberto
      member of: Clinica sagrada esperanca, Luanda, Angola.
  slot:
    index: 16
    item: Stephane KK
      type: Person
      first name: Kouame Koffi
      last name: Stephane
      member of: Institut de cardiologie, CHU Treichville, Abidjan, Côte D'Ivoire.
  slot:
    index: 17
    item: Diakité A
      type: Person
      first name: Adama
      last name: Diakité
      member of: CSREF Commune 2, Bamako, Mali.
  slot:
    index: 18
    item: Stéphane IM
      type: Person
      first name: Ikama Méo
      last name: Stéphane
      member of: CHU de Brazzaville, Brazzaville, Congo.
  slot:
    index: 19
    item: Jeewoth A
      type: Person
      first name: Avinash
      last name: Jeewoth
      member of: Dr. A.G. Jeetoo Hospital, Port Louis, Mauritius.
  slot:
    index: 20
    item: Gandye Y
      type: Person
      first name: Yona
      last name: Gandye
      member of: Jakaya Cardiac Institute, Dar-Es-Salam, Tanzania.
  slot:
    index: 21
    item: Bonny A
      type: Person
      first name: Aimé
      last name: Bonny
      member of: Douala Gyneco-obstetric and Pediatric Hospital/University of Douala, Douala, Cameroon.Centre Hospitalier Le Raincy-Montfermeil, Montfermeil, France.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T06:13
e ISSN: 1540-8167
has issn l: 1045-3873
has NLM journal title abbreviation: J Cardiovasc Electrophysiol
publication name: Journal of cardiovascular electrophysiology
language: eng
has national library of medicine journal id: 9010756
derived from: NLM
has place of publication: United States
source: J Cardiovasc Electrophysiol. 2025-01-07;():.

The Doolin Memorial Lecture 2024.
pmid: 39764773
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Murphy JFA
      type: Person
      first name: J F A
      last name: Murphy
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2025-12-19
dp: 2025 12 19
created: 2025-1-7T07:15
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1041
has place of publication: Ireland
source: Ir Med J. 2025-12-19;117(10):1041.
volume: 117

Understanding nitrous oxide induced subacute combined degeneration of the cord: Two case reports with a review of the pathophysiology and MRI features.
pmid: 39764774
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Mohamed S
      type: Person
      first name: S
      last name: Mohamed
  slot:
    index: 2
    item: Torregiani W
      type: Person
      first name: W
      last name: Torregiani
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:18
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1042
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1042.
volume: 117

Low Yield of Urgent Haemoptysis Referrals for Lung Cancer Clinics.
pmid: 39764776
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Quigley D
      type: Person
      first name: D
      last name: Quigley
  slot:
    index: 2
    item: Piggott L
      type: Person
      first name: L
      last name: Piggott
  slot:
    index: 3
    item: Nadarajan P
      type: Person
      first name: P
      last name: Nadarajan
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:23
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1044
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1044.
volume: 117

Improving the visibility of Rare Diseases in General Medical Practice.
pmid: 39764775
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Timmons A
      type: Person
      first name: A
      last name: Timmons
  slot:
    index: 2
    item: Ward AJ
      type: Person
      first name: A J
      last name: Ward
  slot:
    index: 3
    item: Sweeney G
      type: Person
      first name: G
      last name: Sweeney
  slot:
    index: 4
    item: Nerney D
      type: Person
      first name: D
      last name: Nerney
  slot:
    index: 5
    item: Harris S
      type: Person
      first name: S
      last name: Harris
  slot:
    index: 6
    item: Treacy EP
      type: Person
      first name: E P
      last name: Treacy
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:21
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1042
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1042.
volume: 117

Crying out over spilt milk - Quantifying formula milk waste in a large maternity hospital.
pmid: 39764777
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Hannon M
      type: Person
      first name: M
      last name: Hannon
  slot:
    index: 2
    item: O'Leary E
      type: Person
      first name: E
      last name: O'Leary
  slot:
    index: 3
    item: Daly V
      type: Person
      first name: V
      last name: Daly
  slot:
    index: 4
    item: Burke C
      type: Person
      first name: C
      last name: Burke
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:24
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1045
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1045.
volume: 117

Waste not, want not: measuring waste and potential clinical risk from limited gatekeeping.
pmid: 39764778
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Lynch SA
      type: Person
      first name: S A
      last name: Lynch
  slot:
    index: 2
    item: Butterly D
      type: Person
      first name: D
      last name: Butterly
  slot:
    index: 3
    item: Lambert M
      type: Person
      first name: M
      last name: Lambert
  slot:
    index: 4
    item: Clabby C
      type: Person
      first name: C
      last name: Clabby
  slot:
    index: 5
    item: O'hIci B
      type: Person
      first name: B
      last name: O'hIci
  slot:
    index: 6
    item: Johnston L
      type: Person
      first name: L
      last name: Johnston
  slot:
    index: 7
    item: Kelly S
      type: Person
      first name: S
      last name: Kelly
  slot:
    index: 8
    item: McDonald D
      type: Person
      first name: D
      last name: McDonald
  slot:
    index: 9
    item: McDaid J
      type: Person
      first name: J
      last name: McDaid
  slot:
    index: 10
    item: Ward A
      type: Person
      first name: A
      last name: Ward
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:27
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1046
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1046.
volume: 117

Assessing the quality of transurethral resection of bladder tumour (TURBT) operation notes in line with EAU guidelines.
pmid: 39764780
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Kenny J
      type: Person
      first name: J
      last name: Kenny
  slot:
    index: 2
    item: Connor CJ
      type: Person
      first name: C J
      last name: Connor
  slot:
    index: 3
    item: O'Connell C
      type: Person
      first name: C
      last name: O'Connell
  slot:
    index: 4
    item: Pedro W
      type: Person
      first name: W
      last name: Pedro
  slot:
    index: 5
    item: Keane G
      type: Person
      first name: G
      last name: Keane
  slot:
    index: 6
    item: Galvin D
      type: Person
      first name: D
      last name: Galvin
  slot:
    index: 7
    item: Hegarty N
      type: Person
      first name: N
      last name: Hegarty
  slot:
    index: 8
    item: Connolly S
      type: Person
      first name: S
      last name: Connolly
  slot:
    index: 9
    item: O'Malley KJ
      type: Person
      first name: K J
      last name: O'Malley
  slot:
    index: 10
    item: Nason GL
      type: Person
      first name: G L
      last name: Nason
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:35
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1048
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1048.
volume: 117

The Prevalence of Burnout in Healthcare Workers Presenting to Occupational Health.
pmid: 39764781
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: O'Brien J
      type: Person
      first name: J
      last name: O'Brien
  slot:
    index: 2
    item: Carr P
      type: Person
      first name: P
      last name: Carr
  slot:
    index: 3
    item: Canning E
      type: Person
      first name: E
      last name: Canning
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:37
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1049
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1049.
volume: 117

A one year analysis of e-scooter injuries: more than half require specialist follow-up.
pmid: 39764782
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Rigney B
      type: Person
      first name: B
      last name: Rigney
  slot:
    index: 2
    item: Mahoney R
      type: Person
      first name: R
      last name: Mahoney
  slot:
    index: 3
    item: Quinlan JF
      type: Person
      first name: J F
      last name: Quinlan
  slot:
    index: 4
    item: McGoldrick N
      type: Person
      first name: N
      last name: McGoldrick
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:39
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1050
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1050.
volume: 117

The use and benefit of venous blood lactate in ambulatory patients attending the Emergency Department.
pmid: 39764783
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Phelan J
      type: Person
      first name: J
      last name: Phelan
  slot:
    index: 2
    item: Quinn T
      type: Person
      first name: T
      last name: Quinn
  slot:
    index: 3
    item: Jee M
      type: Person
      first name: M
      last name: Jee
  slot:
    index: 4
    item: Foley J
      type: Person
      first name: J
      last name: Foley
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:43
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1051
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1051.
volume: 117

Assessment of a pilot pathway redirecting low acuity emergency department patients.
pmid: 39764784
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ipati C
      type: Person
      first name: C
      last name: Ipati
  slot:
    index: 2
    item: Treacy C
      type: Person
      first name: C
      last name: Treacy
  slot:
    index: 3
    item: Murphy A
      type: Person
      first name: A
      last name: Murphy
  slot:
    index: 4
    item: Kavanagh M
      type: Person
      first name: M
      last name: Kavanagh
  slot:
    index: 5
    item: McCabe A
      type: Person
      first name: A
      last name: McCabe
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:45
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1052
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1052.
volume: 117

Ectopic pregnancy with levonorgestrel-releasing intrauterine device (Jaydess) in situ.
pmid: 39764786
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Babiker A
      type: Person
      first name: A
      last name: Babiker
  slot:
    index: 2
    item: Bashir H
      type: Person
      first name: H
      last name: Bashir
  slot:
    index: 3
    item: Das A
      type: Person
      first name: A
      last name: Das
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:49
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1054
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1054.
volume: 117

The conservative management of a perforated duodenal ulcer in a morbidly obese patient.
pmid: 39764785
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Gilksinson E
      type: Person
      first name: E
      last name: Gilksinson
  slot:
    index: 2
    item: Orsi G
      type: Person
      first name: G
      last name: Orsi
  slot:
    index: 3
    item: McCarthy E
      type: Person
      first name: E
      last name: McCarthy
  slot:
    index: 4
    item: Matrosimone A
      type: Person
      first name: A
      last name: Matrosimone
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:47
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1053
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1053.
volume: 117

Maternal Diaphragmatic Hernia in Pregnancy and Gastric Herniation and Ischaemia.
pmid: 39764787
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Clifford J
      type: Person
      first name: J
      last name: Clifford
  slot:
    index: 2
    item: Ryan OK
      type: Person
      first name: O K
      last name: Ryan
  slot:
    index: 3
    item: Donnelly M
      type: Person
      first name: M
      last name: Donnelly
  slot:
    index: 4
    item: Ahmed O
      type: Person
      first name: O
      last name: Ahmed
  slot:
    index: 5
    item: Almukhlifi T
      type: Person
      first name: T
      last name: Almukhlifi
  slot:
    index: 6
    item: Curran A
      type: Person
      first name: A
      last name: Curran
  slot:
    index: 7
    item: Davis C
      type: Person
      first name: C
      last name: Davis
  slot:
    index: 8
    item: Butt W
      type: Person
      first name: W
      last name: Butt
  slot:
    index: 9
    item: Fearon N
      type: Person
      first name: N
      last name: Fearon
  slot:
    index: 10
    item: Heneghan H
      type: Person
      first name: H
      last name: Heneghan
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:52
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1055
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1055.
volume: 117

Acute Methaemoglobinaemia following ingestion of amyl nitrite.
pmid: 39764788
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: O'Gorman L
      type: Person
      first name: L
      last name: O'Gorman
  slot:
    index: 2
    item: McGurk C
      type: Person
      first name: C
      last name: McGurk
  slot:
    index: 3
    item: Sheehan JR
      type: Person
      first name: J R
      last name: Sheehan
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:57
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1056
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1056.
volume: 117

Fungal splenic abscess secondary to bariatric tourism in an immunocompetent patient.
pmid: 39764789
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Keane A
      type: Person
      first name: A
      last name: Keane
  slot:
    index: 2
    item: Allen MJ
      type: Person
      first name: M J
      last name: Allen
  slot:
    index: 3
    item: Levai A
      type: Person
      first name: A
      last name: Levai
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T07:59
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1057
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1057.
volume: 117

An audit and quality improvement project of STEMI care in a model 3 hospital.
pmid: 39764792
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Murray C
      type: Person
      first name: C
      last name: Murray
  slot:
    index: 2
    item: Mannion J
      type: Person
      first name: J
      last name: Mannion
  slot:
    index: 3
    item: Khan I
      type: Person
      first name: I
      last name: Khan
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T09:12
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1058
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1058.
volume: 117

http://rdf.ncbi.nlm.nih.gov/pubmed/39764791
pmid: 39764791
abstract: The Spanish Society of Pneumology and Thoracic Surgery (SEPAR) and the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) have developed together Clinical Practice Guidelines (GPC) on the management of people affected by tuberculosis (TB) resistant to drugs with activity against Mycobacterium tuberculosis. These clinical practice guidelines include the latest updates of the SEPAR regulations for the diagnosis and treatment of drug-resistant TB from 2017 and 2020 as the starting point. The methodology included asking relevant clinical questions based on PICO methodology, a literature search focusing on each question, and a systematic and comprehensive evaluation of the evidence, with a summary of this evidence for each question. Finally, recommendations were developed and the level of evidence and the strength of each recommendation for each question were established in concordance with the GRADE approach. Of the recommendations made, it is worth highlighting the high quality of the existing evidence for the use of nucleic acid amplification techniques (rapid genotypic tests) as initial tests for the detection of the M. tuberculosis genome and rifampicin resistance in people with presumptive signs or symptoms of pulmonary TB; and for the use of an oral combination of anti-TB drugs based on bedaquiline, delamanid (pretomanid), and linezolid, with conditional fluoroquinolone supplementation (conditioned by fluoroquinolone resistance) for six months for the treatment of people affected by pulmonary multidrug-resistant tuberculosis (MDR-TB). We also recommend directly observed therapy (DOT) or video-observed treatment for the treatment of people affected by DR-TB.
rights: Copyright © 2024 Sociedad Española de Neumología y Cirugía Torácica, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved.
has PII: S0300-2896(24)00310-7
doi: 10.1016/j.arbres.2024.08.001
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Sanchez-Montalva A
      type: Person
      first name: Adrian
      last name: Sanchez-Montalva
      member of: International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, Autonomous University of Barcelona, Spain; Mycobacterial Infections Study Group (GEIM) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain; For Biomedical Research Centre in Infectious Diseases Network (CIBERINFEC), Carlos III Health Institute, Madrid, Spain. Electronic address: adrian.sanchez.montalva@gmail.com.
  slot:
    index: 2
    item: Caminero JA
      type: Person
      first name: José Antonio
      last name: Caminero
      member of: Prof. Head of the Pulmonology Service at the Dr. Negrín General University Hospital, Las Palmas de GC, Spain; Director of Scientific Activities ALOSA TB ACADEMY, Spain.
  slot:
    index: 3
    item: Guna MR
      type: Person
      first name: Mª Remedio
      last name: Guna
      member of: Microbiology Service, General University Hospital Consortium of Valencia, Valencia, Spain; Department of Microbiology and Parasitology, Faculty of Medicine, University of Valencia, Mycobacterial Infections Study Group (GEIM) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain; SEIMC Quality Control, Madrid, Spain.
  slot:
    index: 4
    item: Sanz TR
      type: Person
      first name: Teresa Rodrígo
      last name: Sanz
      member of: Integrated Research Program in Tuberculosis and Non-Tuberculous Mycobacteria (PII-TB&MNT), Centre for Biomedical Research in Public Health Network (CIBERESP), Barcelona Tuberculosis Research Unit, Spain.
  slot:
    index: 5
    item: Rabuñal R
      type: Person
      first name: Ramón
      last name: Rabuñal
      member of: Infectious Diseases Unit, Internal Medicine Department, Lucus Augusti University Hospital, Lugo, Spain; Mycobacterial Infections Study Group (GEIM) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Madrid, Spain.
  slot:
    index: 6
    item: Millet JP
      type: Person
      first name: Joan Pau
      last name: Millet
      member of: Epidemiology Service, Public Health Agency of Barcelona, Barcelona, Spain; Serveis Clínics, Barcelona, Spain; Integrated Research Program in Tuberculosis (PII-TB) of the Spanish Society of Pneumology and Pathology of the Respiratory System (SEPAR), Barcelona, Spain; Centre for Biomedical Research in Epidemiology and Public Health Network (CIBERESP), Carlos III Health Institute, Madrid, Spain.
  slot:
    index: 7
    item: Gullón-Blanco JA
      type: Person
      first name: José Antonio
      last name: Gullón-Blanco
      member of: Pulmonology Section, San Agustín University Hospital, Avilés, Spain.
  slot:
    index: 8
    item: Anibarro L
      type: Person
      first name: Luis
      last name: Anibarro
      member of: Tuberculosis Unit, Infectious Diseases, Internal Medicine Service, University Hospital Complex, Pontevedra, Spain; Immunology Research Group, Galicia Sur Health Research Institute, Spain.
  slot:
    index: 9
    item: Perez-Mendoza G
      type: Person
      first name: Guillermo
      last name: Perez-Mendoza
      member of: Pulmonology Department, Dr. Negrín University Hospital of Gran Canaria, Las Palmas de GC, Spain; PII-TB&MNT & SEPAR Study Group, Spain.
  slot:
    index: 10
    item: Medina JF
      type: Person
      first name: Juan Francisco
      last name: Medina
      member of: Medical-Surgical Unit of Respiratory Diseases (UMQER) Virgen del Rocío University Hospital, Seville, Spain; Integrated Research Program in Tuberculosis and Non-Tuberculous Mycobacteria (PII-TB&MNT), Spain.
  slot:
    index: 11
    item: González-Galán V
      type: Person
      first name: Verónica
      last name: González-Galán
      member of: Clinical Unit of Infectious Diseases, Microbiology, and Clinical Parasitology (UCEIMP), Virgen del Rocío University Hospital, Seville, Spain; Institute of Biomedicine of Seville (IBiS), Clinical and Molecular Microbiology Group, Mycobacteria Line, GEIM-SEIMC Study Group, PII-TB& MNT, SEPARATE, Spain.
  slot:
    index: 12
    item: Tabernero E
      type: Person
      first name: Eva
      last name: Tabernero
      member of: Pulmonology Service, Cruces University Hospital (OSI EEC), Barakaldo, Spain; BioBizkaia Health Research Institute, Spain.
creator: Writing committee of the Spanish MDR TB consortium
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12
dp: 2024 12
created: 2025-1-7T08:58
contributor: OrderedList
  length: 1
  slot:
    index: 1
    item: Álvarez-Mavarez JD
      type: Person
      first name: Juan Diego
      last name: Álvarez-Mavarez
e ISSN: 1579-2129
has issn l: 0300-2896
issue: 12
has NLM journal title abbreviation: Arch Bronconeumol
publication name: Archivos de bronconeumologia
language: engspa
has national library of medicine journal id: 0354720
derived from: NLM
starting page: 759
ending page: 767
has place of publication: Spain
has primary subject term: D018088Q000188
has primary subject term: D012955
has primary subject term: D000995Q000627
has primary subject term: D009169Q000187Q000302Q000235
has subject term: D006801
has subject term: D013030
has subject term: D014397Q000188
has subject term: D015272Q000592
has subject term: D012293Q000627
has subject term: D064687Q000627
has subject term: D055552Q000592Q000458
has subject term: D004359
has subject term: D009593Q000627
has subject term: D000069349Q000627
has subject term: D021141
source: Arch Bronconeumol. 2024-12;60(12):759-767.
title: Executive Summary: Clinical Practice Guidelines on the Management of Resistant Tuberculosis of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) and the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).
volume: 60

An Audit on VTE Thromboprophylaxis and Incidence of Hospital Acquired Thrombosis.
pmid: 39764793
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Koh K
      type: Person
      first name: K
      last name: Koh
  slot:
    index: 2
    item: Koh S
      type: Person
      first name: S
      last name: Koh
  slot:
    index: 3
    item: Hood T
      type: Person
      first name: T
      last name: Hood
  slot:
    index: 4
    item: Mak J
      type: Person
      first name: J
      last name: Mak
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T09:13
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1059
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1059.
volume: 117

All that Glitters is the Golden Patient: Improving staff morale through educational goal setting.
pmid: 39764794
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Devlin E
      type: Person
      first name: E
      last name: Devlin
  slot:
    index: 2
    item: Smith Diakidis D
      type: Person
      first name: D
      last name: Smith Diakidis
  slot:
    index: 3
    item: Belot Z
      type: Person
      first name: Z
      last name: Belot
  slot:
    index: 4
    item: Binti Mohd Nor NS
      type: Person
      first name: N S
      last name: Binti Mohd Nor
  slot:
    index: 5
    item: O'Donnell J
      type: Person
      first name: J
      last name: O'Donnell
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T09:14
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1060
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1060.
volume: 117

Maxillary Lift Technique: Bridging Gaps in Airway Management for Challenging Scenarios.
pmid: 39764795
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Bano F
      type: Person
      first name: F
      last name: Bano
  slot:
    index: 2
    item: Lal S
      type: Person
      first name: S
      last name: Lal
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T09:15
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1061
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1061.
volume: 117

The Use of Biomarkers in Diagnosing Alzheimer's Disease: Recommendations of the Irish Working Group on Biological Approaches to the Diagnosis of Dementia.
pmid: 39764796
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: McKenna MC
      type: Person
      first name: M C
      last name: McKenna
  slot:
    index: 2
    item: O'Philibin L
      type: Person
      first name: L
      last name: O'Philibin
  slot:
    index: 3
    item: Foley T
      type: Person
      first name: T
      last name: Foley
  slot:
    index: 4
    item: Dolan C
      type: Person
      first name: C
      last name: Dolan
  slot:
    index: 5
    item: Kennelly S
      type: Person
      first name: S
      last name: Kennelly
  slot:
    index: 6
    item: O'Dowd S
      type: Person
      first name: S
      last name: O'Dowd
  slot:
    index: 7
    item: O'Connor A
      type: Person
      first name: A
      last name: O'Connor
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-19
dp: 2024 Dec 19
created: 2025-1-7T09:18
ISSN: 0332-3102
has issn l: 0332-3102
issue: 10
has NLM journal title abbreviation: Ir Med J
publication name: Irish medical journal
language: eng
has national library of medicine journal id: 0430275
derived from: NLM
pg: 1062
has place of publication: Ireland
source: Ir Med J. 2024-12-19;117(10):1062.
volume: 117

Short-term efficacy of laparoscopic type C radical hysterectomy by deep uterine vein approach for treatment of cervical cancer.
pmid: 39764801
abstract: This was an original research. The objective of the study was to investigate the efficacy of laparoscopic type C radical hysterectomy by deep uterine vein approach in treating cervical cancer. Two hundred cases of cervical cancer were allocated into control group and intervention group. The control group underwent pelvic lymph node dissection + para-aortic lymph node resection followed by extensive hysterectomy. The intervention group underwent laparoscopic type C radical hysterectomy by deep uterine vein approach + pelvic lymph node dissection ± para-aortic lymph node resection. In comparison with the control group, the intervention group had significantly lower amount of blood loss, longer time of indwelling catheter, shorter time of abdominal drainage tube removal and anal exhaust, lower incidence of postoperative complications, higher rate of pathological stage upgrading, and higher quality of life score, and had lower recurrence rate. We conclude that laparoscopic C-type radical hysterectomy by deep uterine vein approach is effective, safe and reliable, and can promote patients quality of life, which is valuable for clinical use.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 73-81
doi: 10.29063/ajrh2024/v28i12.8
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yu J
      type: Person
      first name: Juanpeng
      last name: Yu
      member of: Department of Gynecology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
  slot:
    index: 2
    item: Yu T
      type: Person
      first name: Ting
      last name: Yu
      member of: Department of Gynecology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
  slot:
    index: 3
    item: Yu S
      type: Person
      first name: Shengsheng
      last name: Yu
      member of: Department of Gynecology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
  slot:
    index: 4
    item: Gao Y
      type: Person
      first name: Yingchun
      last name: Gao
      member of: Department of Gynecology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-7T10:33
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Il s’agissait d’une recherche originale. L'objectif de l'étude était d'étudier l'efficacité de l'hystérectomie radicale laparoscopique de type C par approche veineuse utérine profonde dans le traitement du cancer du col de l'utérus. Deux cents cas de cancer du col de l'utérus ont été répartis dans le groupe témoin et le groupe d'intervention. Le groupe témoin a subi un curage ganglionnaire pelvien + une résection ganglionnaire para-aortique suivie d'une hystérectomie étendue. Le groupe d'intervention a subi une hystérectomie radicale laparoscopique de type C par approche veineuse utérine profonde + curage ganglionnaire pelvien ± résection ganglionnaire para-aortique. Par rapport au groupe témoin, le groupe d'intervention présentait une perte de sang significativement plus faible, une durée de cathéter à demeure plus longue, une durée plus courte du retrait du tube de drainage abdominal et de l'échappement anal, une incidence plus faible de complications postopératoires, un taux plus élevé d'évolution du stade pathologique et un taux plus élevé. score de qualité de vie et présentait un taux de récidive plus faible. Nous concluons que l'hystérectomie radicale laparoscopique de type C par approche veineuse utérine profonde est efficace, sûre et fiable, et peut améliorer la qualité de vie des patientes, ce qui est précieux pour une utilisation clinique.
derived from: NLM
starting page: 73
ending page: 81
has place of publication: Nigeria
has primary subject term: D002583Q000601Q000473
has primary subject term: D007044Q000379
has primary subject term: D010535Q000379
has primary subject term: D008197Q000379
has primary subject term: D011788
has subject term: D006801
has subject term: D005260
has subject term: D008875
has subject term: D016896
has subject term: D000328
has subject term: D011183Q000453
has subject term: D014599Q000601
has subject term: D009367
source: Afr J Reprod Health. 2024-12-31;28(12):73-81.
volume: 28

Predictive value of early pregnancy uric acid levels for adverse pregnancy outcomes.
pmid: 39764802
abstract: Elevated serum uric acid (SUA) levels in pregnancy are linked to adverse outcomes, including preterm birth, preeclampsia, and low birth weight. To assess the predictive value of SUA levels in early pregnancy for adverse pregnancy outcomes (APOs). A cohort of 4,240 pregnant women admitted for delivery from January 2021 to December 2022 was analyzed. APOs were compared between women with hyperuricemia (HUA) (UA > 360 μmol/L) and those without HUA. Logistic regression (LR) analysis was used to identify risk factors for APOs. Among the cohort, 295 women (6.9%) had HUA. Compared to the non-HUA group, the HUA group had a higher BMI (22.45 vs. 21.34), higher rates of hypertension (6.1% vs. 3.4%), preterm birth (10.2% vs. 6.3%), and low birth weight (10.2% vs. 5.9%). Multivariate LR analysis identified elevated UA levels, BMI, diabetes, and preeclampsia as significant risk factors for APOs. The optimal UA threshold for predicting preterm birth was 253.855 μmol/L (sensitivity: 71.4%, specificity: 55.2%). Early pregnancy SUA levels are predictive of adverse pregnancy outcomes, providing a foundation for potential clinical interventions. Given the moderate sensitivity and specificity of the identified SUA threshold for predicting preterm birth, further research is warranted to refine these values and establish their clinical implications in obstetric practice.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 52-60
doi: 10.29063/ajrh2024/v28i12.6
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Lai Q
      type: Person
      first name: Qiaohong
      last name: Lai
      member of: Department of Obstetrics, Xiaolan People's Hospital of Zhongshan (The Fifth People's Hospital of Zhongshan), Zhongshan,528415, China.
  slot:
    index: 2
    item: Zhang X
      type: Person
      first name: Xin
      last name: Zhang
      member of: Department of Obstetrics, Xiaolan People's Hospital of Zhongshan (The Fifth People's Hospital of Zhongshan), Zhongshan,528415, China.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-7T10:40
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Des taux élevés d’acide urique sérique (SUA) pendant la grossesse sont liés à des conséquences indésirables, notamment une naissance prématurée, une prééclampsie et un faible poids à la naissance. Évaluer la valeur prédictive des niveaux de SUA en début de grossesse pour les issues indésirables de la grossesse (APO). Une cohorte de 4 240 femmes enceintes admises pour un accouchement de janvier 2021 à décembre 2022 a été analysée. Les APO ont été comparées entre les femmes atteintes d'hyperuricémie (HUA) (UA > 360 μmol/L) et celles sans HUA. Une analy se de régression logistique (LR) a été utilisée pour identifier les facteurs de risque d'APO. Parmi la cohorte, 295 femmes (6,9 %) souffraient d’HUA. Comparé au groupe non-HUA, le groupe HUA présentait un IMC plus élevé (22,45 contre 21,34), des taux d'hypertension plus élevés (6,1 % contre 3,4 %), une naissance prématurée (10,2 % contre 6,3 %) et un faible poids à la naissance. (10,2% contre 5,9%). L'analyse LR multivariée a identifié des taux élevés d'UA, d'IMC, de diabète et de prééclampsie comme facteurs de risque importants d'APO. Le seuil optimal d’UA pour prédire l’accouchement prématuré était de 253,855 μmol/L (sensibilité : 71,4 %, spécificité : 55,2 %). Les niveaux de SUA en début de grossesse sont prédictifs d’issues indésirables de la grossesse, fournissant ainsi une base pour des interventions cliniques potentielles. Compte tenu de la sensibilité et de la spécificité modérées du seuil SUA identifié pour prédire l'accouchement prématuré, des recherches supplémentaires sont justifiées pour affiner ces valeurs et établir leurs implications cliniques dans la pratique obstétricale.
derived from: NLM
starting page: 52
ending page: 60
has place of publication: Nigeria
has primary subject term: D014527Q000097
has primary subject term: D011256
has primary subject term: D047928Q000453Q000097
has primary subject term: D011225Q000097
has primary subject term: D033461Q000097Q000453
has primary subject term: D011237
has subject term: D006801
has subject term: D005260
has subject term: D011247
has subject term: D000328
has subject term: D012307
has subject term: D007230
has subject term: D011248Q000097
has subject term: D007231
has subject term: D012189
source: Afr J Reprod Health. 2024-12-31;28(12):52-60.
volume: 28

New frontiers in obstetric anesthesiology: Advocacy through innovation.
pmid: 39764805
has PII: S1521-6896(24)00063-6
doi: 10.1016/j.bpa.2024.11.006
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Farber MK
      type: Person
      first name: Michaela K
      last name: Farber
      member of: Division of Obstetric Anesthesiology, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: mfarber@bwh.harvard.edu.
  slot:
    index: 2
    item: Van de Velde M
      type: Person
      first name: Marc
      last name: Van de Velde
      member of: Department of Cardiovascular Sciences, KU Leuven, UZ Leuven, Leuven, Belgium.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 155
ending page: 156
has place of publication: Netherlands
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):155-156.
volume: 38

Epidemiology, trends, and disparities in maternal mortality: A framework for obstetric anesthesiologists.
pmid: 39764806
abstract: Since 2015, reductions in maternal mortality have stalled globally. In some parts of the world, severe maternal morbidity and mortality have increased, and most cases are thought to be from preventable causes. This is further exacerbated by significant racial, ethnic, and geographic disparities in maternal health outcomes, particularly among countries with diverse populations. Etiologies and presentations of maternal death and disease are broad and diverse, often requiring a multidisciplinary approach to address risk and manage medical complexity. Strategies that may reduce morbidity and mortality include the application of risk stratification models and systems for prompt recognition of clinical deterioration, implementation of maternal safety bundles, and point-of care tools such as coagulation testing and ultrasound. This review aims to provide a comprehensive overview of the epidemiology, etiology, and disparities in maternal morbidity and mortality outcomes, and provide a framework for anesthesiologists in helping mitigate risk and improve maternal health outcomes.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00062-4
doi: 10.1016/j.bpa.2024.11.005
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kim JJ
      type: Person
      first name: Jimin J
      last name: Kim
      member of: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, CWN L1, Boston, MA, 02115, USA. Electronic address: jjkim@bwh.harvard.edu.
  slot:
    index: 2
    item: Farber MK
      type: Person
      first name: Michaela K
      last name: Farber
      member of: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, CWN L1, Boston, MA, 02115, USA. Electronic address: mfarber@bwh.harvard.edu.
  slot:
    index: 3
    item: Taha BW
      type: Person
      first name: Bushra W
      last name: Taha
      member of: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, CWN L1, Boston, MA, 02115, USA. Electronic address: btaha@mgb.org.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 157
ending page: 167
has place of publication: Netherlands
has primary subject term: D008428Q000639
has primary subject term: D000072080Q000639Q000592
has primary subject term: D054625Q000639
has subject term: D006801
has subject term: D005260
has subject term: D011247
has subject term: D011248Q000453Q000401
has subject term: D000773Q000379Q000639Q000401
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):157-167.
volume: 38

Initiation and maintenance of neuraxial labour analgesia: A narrative review.
pmid: 39764807
abstract: Labour analgesia is a crucial aspect of obstetric anaesthesia, aiming to alleviate pain during childbirth while ensuring maternal and foetal safety. Over the past decade, advancements in labour analgesia techniques have evolved, impacting initiation, maintenance, and outcomes. We emphasize the longstanding importance of epidural analgesia while recognizing the growing significance of combined spinal-epidural and dural puncture epidural techniques for labour initiation. Analgesia maintenance is optimally achieved with an epidural bolus regimen, either manual boluses, programmed intermittent boluses or patient-controlled epidural analgesia. Utilizing high-volume, low-dose combinations of local anaesthetics with lipophilic opioids demonstrates synergistic effects, facilitating dose reduction and minimising adverse effects. Adjuvants can play a role in specific clinical contexts. The increasing significance of ultrasound guidance for procedural precision is highlighted. The intricate nature of labour pain management underscores the importance of both patient and clinician involvement in decision-making processes. Future advancements in this field have the potential to enhance the well-being of women as well as their newborns.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00055-7
doi: 10.1016/j.bpa.2024.10.005
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Vanderheeren MC
      type: Person
      first name: Marie-Camille
      last name: Vanderheeren
      member of: Department of Anaesthesiology, UZ Leuven, Leuven, Belgium. Electronic address: marie-camille.vanderheeren@uzleuven.be.
  slot:
    index: 2
    item: Van de Velde M
      type: Person
      first name: Marc
      last name: Van de Velde
      member of: Department of Anaesthesiology, UZ Leuven, Leuven, Belgium.
  slot:
    index: 3
    item: Roofthooft E
      type: Person
      first name: Eva
      last name: Roofthooft
      member of: Department of Anaesthesiology, GZA Hospitals, Antwerp, Belgium.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 168
ending page: 175
has place of publication: Netherlands
has primary subject term: D016362Q000379
has primary subject term: D015360Q000379
has subject term: D006801
has subject term: D011247
has subject term: D005260
has subject term: D048949Q000188
has subject term: D016058Q000379
has subject term: D000779Q000008
has subject term: D007743Q000502Q000187
has subject term: D000701Q000008Q000009
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):168-175.
volume: 38

Non-neuraxial labour analgesia.
pmid: 39764808
abstract: Epidural analgesia is considered the gold standard for labour pain but may not be an option for all parturients due to patient choice or medical contraindication. Non-neuraxial alternatives for labour analgesia have been extensively studied and include both pharmacological and non-pharmacological options. Pharmacological options include the use of opioids and inhalational agents while non-pharmacological options range from non-invasive methods such as continuous labour support to techniques such as sterile water injection. Apart from effective analgesia, such techniques may improve maternal satisfaction. This review summarizes the evidence for available non-neuraxial labour analgesia modalities.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00025-9
doi: 10.1016/j.bpa.2024.04.007
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Chen NL
      type: Person
      first name: Ning Lynn
      last name: Chen
      member of: Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore. Electronic address: lynn.chen.ning@singhealth.com.sg.
  slot:
    index: 2
    item: Smyth H
      type: Person
      first name: Hannah
      last name: Smyth
      member of: Department of Anaesthesia, Ulster Hospital, Belfast, Northern Ireland.
  slot:
    index: 3
    item: Sng BL
      type: Person
      first name: Ban Leong
      last name: Sng
      member of: Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore.
  slot:
    index: 4
    item: Hughes D
      type: Person
      first name: Damien
      last name: Hughes
      member of: Department of Anaesthesia, Ulster Hospital, Belfast, Northern Ireland.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 176
ending page: 186
has place of publication: Netherlands
has primary subject term: D016362Q000379
has primary subject term: D048949Q000628Q000188
has subject term: D006801
has subject term: D011247
has subject term: D005260
has subject term: D015360Q000379
has subject term: D000701Q000008
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):176-186.
volume: 38

Cesarean delivery: Clinical updates.
pmid: 39764809
abstract: This article offers a comprehensive clinical update on best practices for neuraxial and general anesthesia in cesarean delivery, the most frequently performed major surgical procedure globally. Current evidence-based strategies to address common anesthetic challenges, such as maternal hypotension and intraoperative breakthrough pain, are discussed in detail. Practical approaches for optimizing maternal hemodynamic stability, including the use of vasopressors, fluid management and maternal positioning, are reviewed. Additionally, the article explores best practices for general anesthesia, with an emphasis on new approaches to prolonging safe apnea time, rapid sequence induction and difficult airway management.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00060-0
doi: 10.1016/j.bpa.2024.11.003
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lee A
      type: Person
      first name: Allison
      last name: Lee
      member of: Perelman School of Medicine, University of Pennsylvania, Department of Anesthesiology and Critical Care, 3400 Spruce St, Suite 680 Dulles, Philadelphia, PA, 19104, USA. Electronic address: allison.lee@pennmedicine.upenn.edu.
  slot:
    index: 2
    item: Estevez MG
      type: Person
      first name: Max Gonzalez
      last name: Estevez
      member of: Medicine Department, Lille University, Pôle d'Anesthésie Réanimation Médecine Péri-opératoire et Douleur, Centre Hospitalier Universitaire de Lille, 2 Rue Oscar Lambret, 59 037, Lille Cedex, France. Electronic address: max.gonzalezestevez@chu-lille.fr.
  slot:
    index: 3
    item: Le Gouez A
      type: Person
      first name: Agnès
      last name: Le Gouez
      member of: K. Bicetre School of Medicine, Paris-Saclay University, Département d'Anesthésie, Hôpital Antoine Béclère - APHP.Université Paris-Saclay, 157 rue de la porte de Trivaux, 92140, CLAMART, France. Electronic address: agnes.le-gouez@aphp.fr.
  slot:
    index: 4
    item: Mercier FJ
      type: Person
      first name: Frédéric J
      last name: Mercier
      member of: K. Bicetre School of Medicine, Paris-Saclay University, Département d'Anesthésie, Hôpital Antoine Béclère - APHP.Université Paris-Saclay, 157 rue de la porte de Trivaux, 92140, CLAMART, France. Electronic address: frederic.mercier@aphp.fr.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 187
ending page: 198
has place of publication: Netherlands
has primary subject term: D002585Q000379
has primary subject term: D000773Q000379
has subject term: D006801
has subject term: D011247
has subject term: D005260
has subject term: D000768Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):187-198.
volume: 38

Optimising recovery after caesarean delivery.
pmid: 39764810
abstract: Caesarean delivery is the most performed inpatient surgery worldwide, with rates expected to rise. Optimising maternal recovery benefits not only the mother, but also the newborn and society. Enhanced Recovery After Caesarean delivery (ERAC) protocols standardize the approach to perioperative management of patients in order to accelerate early postoperative maternal rehabilitation. Implementation of ERAC protocols has been associated with improved maternal and neonatal outcomes including shorter hospital stay, lower pain scores and opioid consumption, fewer complications, higher maternal satisfaction, and greater breastfeeding success. Higher-quality evidence is needed to support and evaluate ERAC protocols as they continue to be refined with the application of regional analgesia and an individualized approach to pain management. Recent work has described the postpartum period as a complex multidimensional process. A holistic approach to measuring postpartum recovery could provide valuable insights for tailoring interventions and supporting services to promote maternal recovery after caesarean delivery.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00053-3
doi: 10.1016/j.bpa.2024.10.003
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ciechanowicz S
      type: Person
      first name: Sarah
      last name: Ciechanowicz
      member of: Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, USA; Department of Anaesthesia and Perioperative Medicine, University College London Hospital NHS Foundation Trust, London, UK. Electronic address: s.ciechanowicz@nhs.net.
  slot:
    index: 2
    item: De Greef E
      type: Person
      first name: Evy
      last name: De Greef
      member of: Department of Anesthesiology, University Hospital Leuven, Belgium.
  slot:
    index: 3
    item: Van de Velde M
      type: Person
      first name: Marc
      last name: Van de Velde
      member of: Department of Anesthesiology, University Hospital Leuven, Belgium.
  slot:
    index: 4
    item: Sultan P
      type: Person
      first name: Pervez
      last name: Sultan
      member of: Department of Anesthesiology, University Hospital Leuven, Belgium.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 199
ending page: 208
has place of publication: Netherlands
has primary subject term: D002585Q000379
has subject term: D006801
has subject term: D005260
has subject term: D011247
has subject term: http://id.nlm.nih.gov/mesh/D000080482
has subject term: D010149Q000517
has subject term: D007231
has subject term: D059408Q000379
has subject term: D020127Q000502
has subject term: D019990Q000379
has subject term: D007902
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):199-208.
volume: 38

Uterotonics update.
pmid: 39764811
abstract: Uterotonics are the mainstay of management for postpartum haemorrhage and an understanding of their use is essential for the obstetric anaesthetist. First-line uterotonics comprise oxytocin and carbetocin, which act on the oxytocin receptor, and recent research has shown that lower doses of first-line uterotonics can be used to adequate effect. The oxytocin receptor is known to undergo desensitisation with exposure to the agonist over time and with increasing concentrations. Therefore, second-line uterotonics, such as ergometrine, carboprost, sulprostone or misoprostol, need to be considered earlier than they have been in past clinical practice. Choice of second-line uterotonic will vary depending on the comorbidities of the patient. This article will outline each of the available first- and second-line uterotonics, their mechanisms of action, pharmacokinetics, side effects and contraindications. Comparisons between them will also be discussed, as well as differences in superiority and guidance on dosing, based on recent evidence.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00057-0
doi: 10.1016/j.bpa.2024.10.007
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Onwochei DN
      type: Person
      first name: Desire N
      last name: Onwochei
      member of: Department of Anaesthesia, Guy's & St. Thomas' NHS Foundation Trust, London, UK; King's College London, London, UK. Electronic address: desire.onwochei@gstt.nhs.uk.
  slot:
    index: 2
    item: Desai N
      type: Person
      first name: Neel
      last name: Desai
      member of: Department of Anaesthesia, Guy's & St. Thomas' NHS Foundation Trust, London, UK; King's College London, London, UK. Electronic address: neel.desai@gstt.nhs.uk.
  slot:
    index: 3
    item: Tsen LC
      type: Person
      first name: Lawrence C
      last name: Tsen
      member of: Center for Reproductive Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, USA. Electronic address: ltsen@bwh.harvard.edu.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 209
ending page: 220
has place of publication: Netherlands
has primary subject term: D010120Q000008Q000493
has primary subject term: D006473
has primary subject term: D010121Q000008Q000493
has subject term: D006801
has subject term: D005260
has subject term: D011247
has subject term: D000773Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):209-220.
volume: 38

Postpartum hemorrhage assessment and targeted treatment.
pmid: 39764812
abstract: Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide, and mitigating it is a global health priority. In this review, we discuss the measurement, assessment, and treatment of PPH. We review different methods of quantifying blood loss, including gravimetry, calibrated drapes and canisters, and colorimetric techniques. Additionally, we highlight the importance of obstetric-specific massive transfusion protocols, point-of-care coagulation testing, and the role of fibrinogen and tranexamic acid. Lastly, we review placenta accreta spectrum management. Anesthesiologists are critical participants in the management of PPH, ultimately influencing patient outcomes.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00054-5
doi: 10.1016/j.bpa.2024.10.004
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Mootz AA
      type: Person
      first name: Allison A
      last name: Mootz
      member of: Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA; Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center & Parkland Memorial Hospital, 5323 Harry Hines Blvd, Dallas, Texas, 75390, USA. Electronic address: allison.mootz@utsouthwestern.edu.
  slot:
    index: 2
    item: Kowalczyk JJ
      type: Person
      first name: John J
      last name: Kowalczyk
      member of: Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA. Electronic address: jkowalczyk@bwh.harvard.edu.
  slot:
    index: 3
    item: Seifert SM
      type: Person
      first name: Sebastian M
      last name: Seifert
      member of: Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA. Electronic address: sseifert@bwh.harvard.edu.
  slot:
    index: 4
    item: Katz D
      type: Person
      first name: Daniel
      last name: Katz
      member of: Department of Anesthesiology, Perioperative, and Pain Medicine, Mount Sinai, 1468 Madison Avenue, New York, NY, 10029, USA. Electronic address: daniel.katz@mountsinai.org.
  slot:
    index: 5
    item: Reale SC
      type: Person
      first name: Sharon C
      last name: Reale
      member of: Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA. Electronic address: screale@bwh.harvard.edu.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 221
ending page: 232
has place of publication: Netherlands
has primary subject term: D006473Q000628Q000175
has subject term: D006801
has subject term: D005260
has subject term: D011247
has subject term: D001803Q000379
has subject term: D014148Q000008
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):221-232.
volume: 38

Navigating coagulopathy in obstetric hemorrhage: The role of point-of-care testing.
pmid: 39764813
abstract: Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality and morbidity worldwide. Recent advances in understanding the hemostatic changes of pregnancy and PPH have led to the development of obstetric-specific approaches to resuscitation. This article aims to examine. 1) changes in the coagulation system during pregnancy. 2) types of coagulopathy associated with PPH, and. 3) the role of point of care tests of coagulation in PPH.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00052-1
doi: 10.1016/j.bpa.2024.10.002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Gill N
      type: Person
      first name: Nicholas
      last name: Gill
      member of: Department of Anaesthesia and Perioperative Medicine, Cardiff and Vale University Hospital, Cardiff, UK. Electronic address: nicholas.gill@wales.nhs.uk.
  slot:
    index: 2
    item: Butwick A
      type: Person
      first name: Alexander
      last name: Butwick
      member of: Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  slot:
    index: 3
    item: Bell SF
      type: Person
      first name: Sarah F
      last name: Bell
      member of: Department of Anaesthesia and Perioperative Medicine, Cardiff and Vale University Hospital, Cardiff, UK.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 233
ending page: 245
has place of publication: Netherlands
has primary subject term: D006473Q000628Q000175Q000097
has primary subject term: D001778Q000175Q000628Q000209Q000097
has primary subject term: http://id.nlm.nih.gov/mesh/D000067716
has subject term: D006801
has subject term: D005260
has subject term: D011247
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):233-245.
volume: 38

Morbid obesity: Optimizing neuraxial analgesia and cesarean delivery outcomes.
pmid: 39764815
abstract: The issue of obesity continues to reach new levels globally, affecting individuals across the age continuum. Obesity in pregnancy is associated with myriad comorbidities which may negatively impact the fetus, particularly dysfunctional labor and failure to progress ending in unplanned cesarean delivery. Neuraxial anesthesia represents the gold standard for cesarean delivery anesthesia and is increasingly beneficial for obese patients due to the risk of difficult airway. Obese parturients demonstrate higher rates of venous thromboembolism and wound infections and appropriate prophylaxis strategies to prevent these complications is imperative. While neuraxial anesthesia is the preferred technique for peripartum analgesia and cesarean delivery anesthesia, procedures can be technically challenging in patients with obesity, and may require more time, longer needles, increased experience, or ultrasound guidance. There is some concern for respiratory depression with the administration of neuraxial opioids in patients with obesity which has culminated in the development of post-operative monitoring guidelines.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00059-4
doi: 10.1016/j.bpa.2024.11.002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Dominguez JE
      type: Person
      first name: Jennifer E
      last name: Dominguez
      member of: Department of Anesthesiology, Division of Women's Anesthesia, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address: ctaylor@ecaa.com.
  slot:
    index: 2
    item: Taylor CR
      type: Person
      first name: Cameron R
      last name: Taylor
      member of: East Carolina Anesthesia Associates, WakeMed Hospital System, Greenville, NC, 27834, USA.
  slot:
    index: 3
    item: Girard T
      type: Person
      first name: Thierry
      last name: Girard
      member of: Department of Anesthesiology, University Hospital Basel, Basel, Switzerland.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 257
ending page: 266
has place of publication: Netherlands
has primary subject term: D002585Q000379Q000009
has primary subject term: D009767
has primary subject term: D016362Q000379
has subject term: D006801
has subject term: D011247
has subject term: D005260
has subject term: D000773Q000379
has subject term: D011248Q000517
has subject term: D016896
has subject term: D015360Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):257-266.
volume: 38

Postdural puncture headache: Beyond the evidence.
pmid: 39764816
abstract: Despite advances in procedural techniques and equipment, postdural puncture headache (PDPH) remains a serious complication of labour epidural analgesia after accidental dural puncture (ADP). Often considered a temporary inconvenience, PDPH can be debilitating in the short term. It can also be associated with chronic manifestations and serious complications. The precise underlying mechanisms of PDPH are still incompletely understood, and longstanding beliefs of dysregulation of cerebrospinal fluid (CSF) homeostasis due to CSF fluid loss are currently being challenged. The existence of orthostatic headaches unrelated to CSF loss demands consideration of other mechanisms involved, for instance, related to the autonomic nervous system or the release of calcitonin gene-related peptide (CGRP) associated with activation of the meningeal and cerebral arteries. A multi-society international working group recently provided evidence-based recommendations on the prevention, diagnosis, and management of PDPH resulting from neuraxial procedures. According to the recommendations, there was insufficient evidence to support the routine use of intrathecal catheters or sphenopalatine ganglion blocks to prevent or treat PDPH. Both evidence-based and experimental strategies include stabilizing CSF dynamics through preventing CSF loss, supplementing CSF, or increasing production, and reducing cerebral vasodilation. Future research in PDPH preventive and therapeutic strategies can be facilitated with standardised definitions, interventions, and outcome measures. Analyses should consider various confounding factors and recognise the complex multifactorial nature of pain experience across diverse populations. Clinical care and research on PDPH will demand a multidisciplinary collaborative effort to elucidate the complexities of its pathophysiology and further improve patient outcome and quality of care.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00061-2
doi: 10.1016/j.bpa.2024.11.004
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Schyns-van den Berg AMJV
      type: Person
      first name: A M J V
      last name: Schyns-van den Berg
      member of: Albert Schweitzer Hospital, Albert Schweitzerplaats 25, 3318, Dordrecht, the Netherlands; Leiden University Medical Centre, Albert Schweitzerplaats 25, 3318, AT Dordrecht, Leiden, the Netherlands. Electronic address: xschyns@me.com.
  slot:
    index: 2
    item: Lucas DN
      type: Person
      first name: D N
      last name: Lucas
      member of: Northwick Park Hospital Middlesex, UK. Electronic address: nuala.lucas@nhs.net.
  slot:
    index: 3
    item: Leffert LR
      type: Person
      first name: L R
      last name: Leffert
      member of: Yale Medicine/Yale New Haven Health System, USA. Electronic address: Lisa.Leffert@Yale.edu.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 267
ending page: 277
has place of publication: Netherlands
has primary subject term: D051299Q000517
has subject term: D006801
has subject term: D011247
has subject term: D015360Q000379Q000009
has subject term: D005260
has subject term: D016362Q000379Q000009
has subject term: D019317Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):267-277.
volume: 38

Managing cardiovascular disease in pregnant people: Defining the pregnancy heart team.
pmid: 39764817
abstract: Cardiovascular disease is a leading cause of morbidity and mortality for pregnant patients. A significant portion of cardiac morbidity and mortality is preventable and related to poor or delayed recognition of clinical warning signs and oversights in management. The establishment of pregnancy heart teams facilitates multidisciplinary planning to improve management of people with cardiovascular disease. Core members of the pregnancy heart team include obstetricians, midwives, cardiologists, anesthesiologists, nurses, and patient care coordinators. Additional specialists and subspecialists are included on pregnancy heart teams based on individual patient needs. This review discusses the practical aspects of the pregnancy heart team's approach to caring for pregnant people with cardiovascular disease.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00051-X
doi: 10.1016/j.bpa.2024.10.001
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ernst L
      type: Person
      first name: Liliane
      last name: Ernst
      member of: Department of Anesthesiology, Duke University Medical Center, DUMC, 3094, Durham, NC, 27710, USA. Electronic address: Liliane.r.ernst@gmail.com.
  slot:
    index: 2
    item: Meng ML
      type: Person
      first name: Marie-Louise
      last name: Meng
      member of: Department of Anesthesiology, Duke University Medical Center, DUMC, 3094, Durham, NC, 27710, USA. Electronic address: marielouise.meng@duke.edu.
  slot:
    index: 3
    item: Quist-Nelson J
      type: Person
      first name: Johanna
      last name: Quist-Nelson
      member of: Department of Obstetrics and Gynecology, University of North Carolina, 3009 Old Clinic Building, CB 7570, Chapel Hill, NC, 27599, USA. Electronic address: Johanna_quist-nelson@med.unc.edu.
  slot:
    index: 4
    item: Zentner D
      type: Person
      first name: Dominica
      last name: Zentner
      member of: Department of Medicine, University of Melbourne, Melbourne, Australia and Department of Cardiology, Royal Melbourne Hospital, 300 Grattan St, Parkville, VIC, 3052, Australia. Electronic address: dominica.zentner@mh.org.au.
  slot:
    index: 5
    item: Dennis AT
      type: Person
      first name: Alicia T
      last name: Dennis
      member of: Joan Kirner Women's and Children's Sunshine Hospital, Western Health, St Albans, Australia. Electronic address: adennis@unimelb.edu.au.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 278
ending page: 292
has place of publication: Netherlands
has primary subject term: D011249Q000628Q000175Q000503
has primary subject term: D010348
has primary subject term: D002318Q000628Q000175
has subject term: D006801
has subject term: D011247
has subject term: D005260
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):278-292.
volume: 38

Thoracic anesthesia, ventilation, and oxygen delivery: 'A review of the recent advancements'.
pmid: 39764820
has PII: S1521-6896(24)00031-4
doi: 10.1016/j.bpa.2024.05.005
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Bouchez S
      type: Person
      first name: Stefaan
      last name: Bouchez
      member of: OLV Clinic Aalst, Belgium. Electronic address: Stefaan.bouchez@olvz-aalst.be.
  slot:
    index: 2
    item: Hendrickx JFA
      type: Person
      first name: Jan F A
      last name: Hendrickx
      member of: OLV Clinic Aalst, Belgium.
  slot:
    index: 3
    item: Popescu WM
      type: Person
      first name: Wanda M
      last name: Popescu
      member of: Yale School of Medicine, USA.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 1
ending page: 3
has place of publication: Netherlands
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):1-3.
volume: 38

Extracorporeal membrane oxygenation and pregnancy.
pmid: 39764818
abstract: Critical illness during pregnancy poses significant challenges driven by complex interactions between physiological changes, pre-existing conditions, and healthcare disparities. In high-income countries, increasing maternal age and comorbidities complicate obstetric care by triggering an unprecedented rise in cardiac disease during pregnancy, while infections like influenza and COVID-19 are important causes of maternal adult respiratory distress syndrome. Extracorporeal membrane oxygenation (ECMO) gained prominence as a vital intervention, providing respiratory and/or cardiac support, for varying indications between antenatal and postpartum periods. The physiological changes of pregnancy demand close attention and adjustment of ECMO parameters, along with multidisciplinary collaboration. While potential complications such as bleeding and thromboembolism require vigilant management and optimal management of ECMO support in pregnancy still needs to be elucidated, ECMO nevertheless yields favorable maternal and fetal outcomes.
rights: Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
has PII: S1521-6896(24)00056-9
doi: 10.1016/j.bpa.2024.10.006
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wong MJ
      type: Person
      first name: M J
      last name: Wong
      member of: Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Saint John Regional Hospital, 400 University Ave, Saint John, NB, E2L 4L2, Canada. Electronic address: mike.wong@dal.ca.
  slot:
    index: 2
    item: Kodali BS
      type: Person
      first name: B S
      last name: Kodali
      member of: Department of Anesthesiology, University of Maryland Medical Center, University of Medicine School of Medicine, 22 S. Greene Street, Baltimore, MD, 21201, USA.
  slot:
    index: 3
    item: Rex S
      type: Person
      first name: S
      last name: Rex
      member of: Department of Anaesthesiology, University Hospitals Leuven (BE), Department of Cardiovascular Sciences, KU Leuven (BE), Herestraat 49, B-3000, Leuven, Belgium.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-09
dp: 2024 Sep
created: 2025-1-7T10:50
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 3
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 293
ending page: 301
has place of publication: Netherlands
has primary subject term: D015199Q000379
has primary subject term: D000086382Q000628
has primary subject term: D011248Q000628
has subject term: D006801
has subject term: D011247
has subject term: D005260
source: Best Pract Res Clin Anaesthesiol. 2024-09;38(3):293-301.
volume: 38

Utility of ultrasound in thoracic anesthesia.
pmid: 39764821
abstract: The use of ultrasound (US) in the perioperative clinical management should be goal-directed, rapid, and reproducible. Thoracic US enables detailed examinations of vital structures, such as the airway, lung, pleural space, diaphragm, and heart. This chapter focuses on the value of US as a bedside tool to assess anatomy, guide procedures, and monitor vital organ function in patients undergoing thoracic surgery.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00021-1
doi: 10.1016/j.bpa.2024.04.003
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Bouchez S
      type: Person
      first name: Stefaan
      last name: Bouchez
      member of: Department of Anaesthesiology, Intensive care and Emergency Medicine, OLV Clinic, Aalst, Belgium. Electronic address: Stefaan.bouchez@olvz-aalst.be.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 18
ending page: 31
has place of publication: Netherlands
has primary subject term: D019616Q000379
has primary subject term: D000758Q000379
has primary subject term: D014463Q000379
has subject term: D006801
has subject term: D018084Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):18-31.
volume: 38

Intravenous iron therapy for treating patients with iron deficiency anaemia during the perioperative period of gynecological malignancy.
pmid: 39764819
abstract: Anaemia is a common phenomenon in patients with malignant gynecological tumors. The occurrence of anaemia in the perioperative period leads to an increased probability of blood transfusion, increased surgical complications,poor wound healing, prolonged hospitalization, increased medical costs, and increased mortality. Intravenous iron, which is known for its rapid onset and lack of gastrointestinal side effects, has become increasingly prevalent in clinical practice. A total of 300 patients with gynaecological malignancies were admitted to The First Affiliated Hospital,Hengyang Medical School,University of South China between January, 2019 and December , 2021. Anaemia was assessed during routine blood tests by measuring red blood cell (RBC) counts, hemoglobin (Hb) levels, haematocrit (HCT) values, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). The postoperative blood transfusion rate, transfusion volume, infection rate, and hospitalization duration were also recorded and comparisons were made between the control and treatment groups.Our study showed that preoperative intravenous iron injection can effectively increase haemoglobin levels in patients with anemia caused by gynecological cancer, reduces the probability of perioperative blood transfusion., decreases postoperative complications and infection rates, shortens hospital stays, and improves short-term prognosis in patients. We concluded that intravenous iron presents is a valuable clinical option for addressing perioperative anaemia in patients with gynecologic malignancies.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 82-87
doi: 10.29063/ajrh2024/v28i12.9
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Deng Z
      type: Person
      first name: Zhizhi
      last name: Deng
      member of: Gynecology &Obstetrics and Reproductive Medical Center,The First Affiliated Hospital, Hengyang Medical School,University of South China.
  slot:
    index: 2
    item: Zhou X
      type: Person
      first name: Xi
      last name: Zhou
      member of: Gynecology &Obstetrics and Reproductive Medical Center,The First Affiliated Hospital, Hengyang Medical School,University of South China.
  slot:
    index: 3
    item: He G
      type: Person
      first name: Guicheng
      last name: He
      member of: Department of Medical Oncology, The First Affiliated Hospital,Hengyang Medical School,University of South China.
  slot:
    index: 4
    item: Yang N
      type: Person
      first name: Na
      last name: Yang
      member of: Gynecology &Obstetrics and Reproductive Medical Center,The First Affiliated Hospital, Hengyang Medical School,University of South China.
  slot:
    index: 5
    item: Zhou J
      type: Person
      first name: Jiming
      last name: Zhou
      member of: Department of Cardiology, The First Affiliated Hospital,Hengyang Medical School,University of South China.
created: 2025-1-7T17:10
date last updated: 2025-01-07
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-7T10:51
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: L'anémie est un phénomène courant chez les patientes atteintes de tumeurs gynécologiques malignes. La survenue d'une anémie pendant la période périopératoire entraîne une probabilité accrue de transfusion sanguine, une augmentation des complications chirurgicales, une mauvaise cicatrisation des plaies, une hospitalisation prolongée, une augmentation des coûts médicaux et une mortalité accrue. Le fer intraveineux, connu pour son action rapide et son absence d’effets secondaires gastro-intestinaux, est devenu de plus en plus répandu dans la pratique clinique. Au total, 300 patientes atteintes de tumeurs malignes gynécologiques ont été admises au premier hôpital affilié de la faculté de médecine de Hengyang de l'université de Chine du Sud entre janvier 2019 et décembre 2021. L'anémie a été évaluée lors d'analyses sanguines de routine en mesurant le nombre de globules rouges (GR). taux d'hémoglobine (Hb), valeurs d'hématocrite (HCT), volume corpusculaire moyen (VGM) et volume corpusculaire moyen hémoglobine (MCH). Le taux de transfusion sanguine postopératoire, le volume de transfusion, le taux d'infection et la durée d'hospitalisation ont également été enregistrés et des comparaisons ont été faites entre les groupes témoin et de traitement. Notre étude a montré que l'injection intraveineuse préopératoire de fer peut augmenter efficacement les taux d'hémoglobine chez les patients souffrant d'anémie causée par un cancer gynécologique. , réduit la probabilité de transfusion sanguine périopératoire., diminue les complications postopératoires et les taux d'infection, raccourcit les séjours à l'hôpital et améliore le pronostic à court terme des patients. Nous avons conclu que le fer intraveineux constitue une option clinique précieuse pour traiter l'anémie périopératoire chez les patientes atteintes de tumeurs gynécologiques malignes.
derived from: NLM
starting page: 82
ending page: 87
has place of publication: Nigeria
has primary subject term: D018798Q000188
has primary subject term: D005833Q000601Q000150
has primary subject term: D007501Q000008
has primary subject term: D059035
has subject term: D006801
has subject term: D005260
has subject term: D008875
has subject term: D000328
has subject term: D061605
has subject term: D001803
has subject term: D006454Q000032
has subject term: D002681Q000453
has subject term: D011183Q000453
has subject term: D000368
source: Afr J Reprod Health. 2024-12-31;28(12):82-87.
volume: 28

Robotic bronchoscopy: Evolution of advanced diagnostic technologies for pulmonary lesions.
pmid: 39764823
abstract: Lung cancer is among one of the most commonly diagnosed malignancies and is the leading cause of cancer-related mortality in both men and women globally, with an estimated 1.8 million deaths annually. Moreover, it is also the leading cause of cancer related deaths in the United States (U.S.), with an estimated 127,000 deaths annually. Approximately 50% of patients who undergo chest Computed Tomography (CT) are found to have a pulmonary nodule (PN), albeit 95% of these PNs are subsequently found to be benign. Further complicating the challenge of timely detection of lung cancer, is made more difficult by the fact that most patients are totally asymptomatic in early stage of disease. However, given that sponsored studies by National Cancer Institute (NCI) and other organizations showed a 20% reduction in lung cancer specific mortality with low dose CT scanning in patients at risk, it is reasonable to assume that clinicians will confront this clinical scenario more frequently. Consequently, due to these significant findings, the United States Preventive Services Task Force (USPSTF) recommended annual screening of high-risk patients. Therefore, as result of these recommendations, 240,000 new lung cancers were diagnosed in the U.S. in 2020, with an estimated 238,000 new cases in 2023. Given the multitude of challenges, the practice guidelines and recommendations for the management of these PNs are often tailored to available resources and trained personnel familiar with the various techniques and technologies. This review will discuss the evolution of various advancements when tissue biopsy is required: from sputum cytology, nonguided bronchoscopy, percutaneous CT guided biopsy, guided advanced bronchoscopic techniques such as endobronchial ultrasound (EBUS), radial Endobronchial Ultrasound (rEBUS) to the latest advancement of robotic-assisted bronchoscopy (RAB). Furthermore, as many of the aforementioned techniques require anesthesia, as integral members of the multidis[cell cut: 2748 characters, first 2000 kept]
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00028-4
doi: 10.1016/j.bpa.2024.05.002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ifeanyi IC
      type: Person
      first name: Ifeyinwa C
      last name: Ifeanyi
      member of: 1400 Holcombe Blvd, FC 13.2000, Houston, TX, 77030, USA. Electronic address: icifeanyi@mdanderson.org.
  slot:
    index: 2
    item: Heir JS
      type: Person
      first name: Jagtar Singh
      last name: Heir
      member of: 1400 Holcombe Blvd, FC 13.2000, Houston, TX, 77030, USA. Electronic address: jsheir@mdanderson.org.
  slot:
    index: 3
    item: Idowu O
      type: Person
      first name: Olakunle
      last name: Idowu
      member of: 1400 Holcombe Blvd, FC 13.2000, Houston, TX, 77030, USA. Electronic address: Oidowu@mdanderson.org.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 38
ending page: 46
has place of publication: Netherlands
has primary subject term: D001999Q000379Q000639
has primary subject term: D008175Q000175Q000473Q000000981
has subject term: D006801
has subject term: D065287Q000379Q000639
has subject term: D014057Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):38-46.
volume: 38

Thoracic anesthesia in patients with airborne disease .
pmid: 39764822
abstract: Health care workers are at risk of infection from aerosolization of respiratory secretions, droplet and contact spread. This has gained great importance after the COVID19 pandemic. Intra-operative aerosol-generating procedures are arguably unavoidable in the routine provision of thoracic anesthesia. Airway management for such patients during the COVID-19 pandemic including tracheal intubation, lung isolation, one-lung ventilation and flexible bronchoscopy may pose a significant risk to healthcare professionals and patients. The thoracic anesthetic community has been confronted with the need to modify existing techniques to maximize safety for patients and healthcare professionals.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00019-3
doi: 10.1016/j.bpa.2024.04.001
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Gil MG
      type: Person
      first name: Manuel Granell
      last name: Gil
      member of: Department of Anesthesiology, Postoperative Care and Pain Management, Hospital General Universitario deValència, 46014 Valencia, Spain; Department of Surgery, Universitat de València, 46010 València, Spain. Electronic address: mgranellg@hotmail.com.
  slot:
    index: 2
    item: Plumed RM
      type: Person
      first name: Ruth Martínez
      last name: Plumed
      member of: Department of Anesthesiology, Postoperative Care and Pain Management, Hospital General Universitario deValència, 46014 Valencia, Spain.
  slot:
    index: 3
    item: Grynovska M
      type: Person
      first name: Marta
      last name: Grynovska
      member of: Department of Surgery, Universitat de València, 46010 València, Spain; Ivano-Frankivsk National Medical University, 76018 Ivano-Frankivsk, Ukraine.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 32
ending page: 37
has place of publication: Netherlands
has primary subject term: D000086382Q000517
has subject term: D006801
has subject term: D000758Q000379
has subject term: D000336
has subject term: D058109Q000379
has subject term: D017758Q000517
has subject term: D007442Q000379
has subject term: D019616Q000379
has subject term: D001999Q000379
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):32-37.
volume: 38

Updates in lung isolation techniques.
pmid: 39764824
abstract: Innovations and challenges for lung separation or isolation have evolved during the last few years. In this chapter, we present the up-to-date, robust evidence available during the previous five years supporting the positions of the different devices, techniques, and tricks for their use in adult and pediatric patients undergoing various thoracic surgical interventions. Additionally, we presented an update on lung isolation in patients with airway difficulty and the suggested training level to master these techniques.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00020-X
doi: 10.1016/j.bpa.2024.04.002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Samara E
      type: Person
      first name: Evangelia
      last name: Samara
      member of: Department of Anaesthesiology and Postoperative Intensive Care, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece. Electronic address: gelysamara@uoi.gr.
  slot:
    index: 2
    item: Valauskaite G
      type: Person
      first name: Gabija
      last name: Valauskaite
      member of: Department of Anaesthesia, Intensive Care and Emergency Medicine, OLV Clinic Aalst, Aalst, Belgium. Electronic address: gabija_valauskaite@yahoo.com.
  slot:
    index: 3
    item: El Tahan MR
      type: Person
      first name: Mohamed R
      last name: El Tahan
      member of: Cardiothoracic Anesthesia, Anesthesiology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Cardiothoracic Anaesthesia Unit, Department of Anaesthesia, Surgical Intensive Care and Pain Medicine, College of Medicine, Mansoura University, Mansour, Egypt. Electronic address: mohamedrefaatletahan@yahoo.com.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 4
ending page: 17
has place of publication: Netherlands
has primary subject term: D061810Q000379
has subject term: D006801
has subject term: D019616Q000379
has subject term: D000328
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):4-17.
volume: 38

Extracorporeal membrane oxygenation in thoracic surgery: A game changer!
pmid: 39764825
abstract: The utilization of extracorporeal membrane oxygenation (ECMO) in complex thoracic surgery has become more frequent in recent years due to advances in technology, increased availability, and improved outcomes. ECMO has emerged as a vital tool to facilitate thoracic surgery for patients who would have otherwise been deemed unsuitable candidates. It has redefined the boundaries of surgical possibility where conventional methods fall short. ECMO is typically employed in specific thoracic surgery where conventional ventilation is either inadequate or it interferes with the surgical field, and in procedures demanding both ventilatory and hemodynamic support.
rights: Copyright © 2024. Published by Elsevier Ltd.
has PII: S1521-6896(24)00002-8
doi: 10.1016/j.bpa.2024.01.003
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Glowka L
      type: Person
      first name: Lena
      last name: Glowka
      member of: From the Department of Anesthesiology, Yale School of Medicine, 333 Cedar Street, P.O. Box 208051, New Haven, CT, 06520-8051, USA. Electronic address: lena.glowka@yale.edu.
  slot:
    index: 2
    item: Popescu WM
      type: Person
      first name: Wanda M
      last name: Popescu
      member of: From the Department of Anesthesiology, Yale School of Medicine, 333 Cedar Street, P.O. Box 208051, New Haven, CT, 06520-8051, USA. Electronic address: wanda.popescu@yale.edu.
  slot:
    index: 3
    item: Patel B
      type: Person
      first name: Bhoumesh
      last name: Patel
      member of: From the Department of Anesthesiology, Yale School of Medicine, 333 Cedar Street, P.O. Box 208051, New Haven, CT, 06520-8051, USA. Electronic address: bhoumesh.patel@yale.edu.
created: 2025-1-7T17:12
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 47
ending page: 57
has place of publication: Netherlands
has primary subject term: D015199Q000379Q000639
has primary subject term: D019616Q000379Q000639
has subject term: D006801
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):47-57.
volume: 38

Anesthetic considerations for perioperative ECMO in lung transplantation.
pmid: 39764826
abstract: The care for lung transplantation patients is a complex, multidisciplinary coordination of physician and non-physician teams throughout the perioperative period. The diversity of etiologies of recipient end-stage lung disease further complicate care, as recipients often present with concomitant end-stage cardiac disease. Recently, the use of extracorporeal membrane oxygenation has become the mechanical circulatory support of choice to provide cardiopulmonary stability throughout the perioperative period. This review will focus specifically on the anesthetic considerations for perioperative extracorporeal membrane oxygenation in lung transplantation throughout preoperative bridge to transplantation, intraoperative management, and postoperative utilization.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00016-8
doi: 10.1016/j.bpa.2024.03.002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Fessler J
      type: Person
      first name: Julien
      last name: Fessler
      member of: Department of Anesthesiology and Pain Management, Hospital Foch, Suresnes, France.
  slot:
    index: 2
    item: Vajter J
      type: Person
      first name: Jaromir
      last name: Vajter
      member of: Department of Anesthesiology and Intensive Care Medicine, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
  slot:
    index: 3
    item: Martin AK
      type: Person
      first name: Archer Kilbourne
      last name: Martin
      member of: Division of Cardiovascular and Thoracic Anesthesiology, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA. Electronic address: Martin.Archer@mayo.edu.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 58
ending page: 63
has place of publication: Netherlands
has primary subject term: D016040Q000379
has primary subject term: D015199Q000379
has primary subject term: D019990Q000379
has primary subject term: D000758Q000379
has subject term: D006801
has subject term: D000777Q000008
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):58-63.
volume: 38

The current (and possible future) role of opioid analgesia in lung cancer surgery.
pmid: 39764828
abstract: The objectives of this minireview are two-fold. The first is to discuss the evolution of opioid analgesia in perioperative medicine in the context of thoracic non-cardiac surgery. Current standard-of-care, aiming to optimize analgesia and limit undesirable side effects, is discussed in the context of multimodal analgesia, specifically enhanced recovery after thoracic surgery pathways. The second is to review a developing research program that may ultimately add another element to the personalization of analgesic plans for individual cancer patients based on optimizing oncological outcomes. Termed precision oncoanalgesia, this emerging field aims to elucidate how individual patient-specific tumor omics (genomics, transcriptomics, etc.) may mediate the effects of analgesic drugs on oncological recurrence and survival.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00027-2
doi: 10.1016/j.bpa.2024.05.001
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Pedoto A
      type: Person
      first name: Alessia
      last name: Pedoto
      member of: Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, Department of Anesthesia and Critical Care Medicine, 1275 York Avenue, New York, NY, 10028, USA. Electronic address: pedotoa@mskcc.org.
  slot:
    index: 2
    item: Fischer GW
      type: Person
      first name: Gregory W
      last name: Fischer
      member of: Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, Department of Anesthesia and Critical Care Medicine, 1275 York Avenue, New York, NY, 10028, USA. Electronic address: fischerg@mskcc.org.
  slot:
    index: 3
    item: Mincer JS
      type: Person
      first name: Joshua S
      last name: Mincer
      member of: Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, Department of Anesthesia and Critical Care Medicine, 1275 York Avenue, New York, NY, 10028, USA. Electronic address: mincer@mskcc.org.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 74
ending page: 80
has place of publication: Netherlands
has primary subject term: D000701Q000008
has primary subject term: D010149Q000188Q000517
has primary subject term: D008175Q000601
has subject term: D006801
has subject term: D000698Q000379Q000639
has subject term: D059408Q000379Q000639
has subject term: D019990Q000379Q000639
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):74-80.
volume: 38

Challenges in acute postoperative pain management in thoracic surgery.
pmid: 39764827
abstract: Effective pain control is crucial in the management of thoracic surgical patients since it reduces postoperative morbidity and promotes recovery. These patients have co-existing respiratory diseases and impaired pulmonary function, which may be further impaired by surgery. With the adoption of minimally invasive surgical techniques and an emphasis on enhancing recovery after surgery, multimodal analgesia has gained popularity as a way to reduce perioperative opioid use and its associated adverse events such as respiratory depression. The literature related to opioid-sparing analgesia in thoracic surgery is still evolving. This review summarizes the latest research related to the use of various intravenous, oral, and perineural pharmacological agents as a part of multimodal analgesic regimen for pain relief in patients undergoing thoracic surgery and provides a summary for their application in clinical practice.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00003-X
doi: 10.1016/j.bpa.2024.01.002
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Makkad B
      type: Person
      first name: Benu
      last name: Makkad
      member of: Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, 45267, OH, United States. Electronic address: Benu.Makkad@gmail.com.
  slot:
    index: 2
    item: Kachulis B
      type: Person
      first name: Bessie
      last name: Kachulis
      member of: Department of Anesthesiology, Columbia University, 622 W 168th St, New York, 10032, NY, United States. Electronic address: Bk127@cumc.columbia.edu.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 64
ending page: 73
has place of publication: Netherlands
has primary subject term: D010149Q000517
has primary subject term: D019616Q000379Q000009
has primary subject term: D059408Q000379
has subject term: D006801
has subject term: D059787Q000517
has subject term: D000700Q000008
has subject term: D000701Q000008
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):64-73.
volume: 38

Postoperative care after thoracic surgery in the times of ERAS.
pmid: 39764829
abstract: This review documents the importance of postoperative interventions that accelerate the functional recovery of the thoracic surgical patient. Enhanced recovery after surgery (ERAS) pathways aim to mitigate the harmful surgical stress response. Improvements to the entire patient pathway, by removing unnecessary care elements while introducing evidence-based interventions, have synergistic effects. At the same time, some key care elements appear to be more important than others, including early removal of chest tubes, early mobilization, and the limited use of opioids. These care elements are all intertwined. The goals of early mobilization and opioid-sparing analgesia are more readily achieved once a chest tube has been removed. A focus on achieving these goals earlier, including on the day of surgery, may benefit a patient's recovery further. The result is superior patient outcomes including a quicker restoration of normal function, fewer complications, reduced opioid requirements, reduced costs, and a shorter length of stay.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(24)00022-3
doi: 10.1016/j.bpa.2024.04.004
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Batchelor TJP
      type: Person
      first name: Timothy J P
      last name: Batchelor
      member of: Department of Thoracic Surgery, Barts Thorax Centre, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK. Electronic address: tim.batchelor@nhs.net.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-03
dp: 2024 Mar
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 1
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 81
ending page: 89
has place of publication: Netherlands
has primary subject term: D019616Q000379Q000639
has primary subject term: D011182Q000379Q000639
has primary subject term: http://id.nlm.nih.gov/mesh/D000080482
has subject term: D006801
has subject term: D000701Q000008
has subject term: D010149Q000517
has subject term: D004434Q000379
has subject term: D007902
has subject term: D011183Q000517
source: Best Pract Res Clin Anaesthesiol. 2024-03;38(1):81-89.
volume: 38

Roads travelled: The journey to Patient Blood Management at 35 years.
pmid: 39764831
abstract: Patient Blood Management evolved in recent years, focusing on the haematopoietic system as relevant to all disciplines of medicine. The allogeneic blood supply chain travels from donation, to fractionation, preservation, and storage, to therapeutic, established treatments, or prophylactics for a wide range of medical conditions. This supply chain 'connects' altruistic blood donors to patients in need, symbolising a 'gift relationship', emphasising the empathetic bond between donor and recipient. In 1988, the author proposed a paradigm shift in blood transfusion and, in 2005, introduced the term Patient Blood Management (PBM). PBM's origins are traceable to the late 19th century, when blood transfusion wasn't feasible for managing exsanguinating haemorrhage or critical anaemia. Landsteiner's discovery of the ABO blood groups firmly established blood component therapy into medical therapeutics. This article recounts the journey from a pre-blood transfusion era patient-centred approach, through the 20th century's blood product focus, and thenceforth back to the patient with the advent of PBM.
rights: Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
has PII: S1521-6896(23)00050-2
doi: 10.1016/j.bpa.2023.10.001
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Isbister JP
      type: Person
      first name: James P
      last name: Isbister
      member of: Sydney Medical School, University of Sydney, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW 2065, Australia. Electronic address: jpisbister@gmail.com.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 439
ending page: 450
has place of publication: Netherlands
has primary subject term: D001803Q000379Q000266
has subject term: D006801
has subject term: D049673
has subject term: D049674
has subject term: D001782
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):439-450.
volume: 37

Patient blood management.
pmid: 39764830
has PII: S1521-6896(24)00001-6
doi: 10.1016/j.bpa.2024.01.001
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Miles LF
      type: Person
      first name: Lachlan F
      last name: Miles
      member of: Department of Anaesthesia, Austin Health, Melbourne, Australia; Department of Critical Care, Melbourne Medical School, The University of Melbourne, Melbourne, Australia. Electronic address: lachlan.miles@unimelb.edu.au.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 437
ending page: 438
has place of publication: Netherlands
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):437-438.
volume: 37

Intra-operative tranexamic acid: A standard of care?
pmid: 39764833
abstract: Peri-operative bleeding is a major cause of morbidity and mortality in patients undergoing surgery. Tranexamic acid, an antifibrinolytic agent, is effective for prevention and treatment of bleeding in a variety of different surgical populations. This review summarizes the evidence supporting the use of tranexamic acid in major surgical settings including cardiac surgery, obstetrics, orthopedic surgery, and non-cardiac surgery. We discuss potential adverse effects with use of tranexamic acid including the theoretical risk of thrombosis. Lastly, we discuss other potential benefits of tranexamic acid including prevention of infection and maintenance of blood-brain barrier integrity.
rights: Copyright © 2023. Published by Elsevier Ltd.
has PII: S1521-6896(23)00059-9
doi: 10.1016/j.bpa.2023.11.006
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Relke N
      type: Person
      first name: Nicole
      last name: Relke
      member of: Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
  slot:
    index: 2
    item: Tang GH
      type: Person
      first name: Grace H
      last name: Tang
      member of: Division of Hematology, Departments of Medicine, and Laboratory Medicine and Pathobiology, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, ON, Canada.
  slot:
    index: 3
    item: Sholzberg M
      type: Person
      first name: Michelle
      last name: Sholzberg
      member of: Division of Hematology, Departments of Medicine, and Laboratory Medicine and Pathobiology, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, ON, Canada. Electronic address: michelle.sholzberg@unityhealth.to.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 468
ending page: 476
has place of publication: Netherlands
has primary subject term: D014148Q000008
has primary subject term: D000933Q000008
has primary subject term: D016063Q000517
has primary subject term: D059039
has subject term: D006801
has subject term: D007430Q000379Q000592
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):468-476.
volume: 37

Diagnosing iron deficiency: Controversies and novel metrics.
pmid: 39764832
abstract: Iron deficiency, a pervasive global health issue, necessitates precise and reliable diagnostic methods, especially in clinical and surgical settings. This review examines an array of established markers of iron status, encapsulating parameters such as serum iron, ferritin, transferrin, and transferrin saturation alongside novel biomarkers like soluble transferrin receptor, zinc protoporphyrin, and hepcidin. We further scrutinise the potential and limitations of routine and novel diagnostic tools and strategies in distinguishing different anaemic conditions, such as iron deficiency anaemia, iron-restricted erythropoiesis, and anaemia of inflammation. Through a critical lens, we elucidate the current paradigms and pressing questions surrounding the diagnostic criteria and clinical ramifications of iron metabolism. By weaving together the nuances and diverging perspectives within the domain of iron deficiency diagnosis and management, this review aspires to foster a clearer understanding that can steer improved patient care and shape the trajectory of future research in this vital field.
rights: Copyright © 2023 The Author. Published by Elsevier Ltd.. All rights reserved.
has PII: S1521-6896(23)00054-X
doi: 10.1016/j.bpa.2023.11.001
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Rusch JA
      type: Person
      first name: Jody A
      last name: Rusch
      member of: Division of Chemical Pathology, Department of Pathology, University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa. Electronic address: jody.rusch@uct.ac.za.
  slot:
    index: 2
    item: van der Westhuizen DJ
      type: Person
      first name: Diederick J
      last name: van der Westhuizen
      member of: Division of Chemical Pathology, Department of Pathology, University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa.
  slot:
    index: 3
    item: Gill RS
      type: Person
      first name: Robert S
      last name: Gill
      member of: Department of Medicine, J-floor, Old Main Building, Groote Schuur Hospital, Observatory, Cape Town, South Africa.
  slot:
    index: 4
    item: Louw VJ
      type: Person
      first name: Vernon J
      last name: Louw
      member of: Division of Clinical Haematology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 451
ending page: 467
has place of publication: Netherlands
has primary subject term: D018798Q000175Q000097
has primary subject term: D015415Q000097Q000378
has primary subject term: D007501Q000097Q000378
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000090463
has subject term: D005293Q000097
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):451-467.
volume: 37

Postoperative anaemia: Hiding in plain sight.
pmid: 39764835
abstract: Postoperative anaemia is common among surgical patients. While often viewed as a benign condition, postoperative anaemia is neither inevitable nor harmless, being intricately linked with adverse outcomes. In this review, we summarize the prevalence, aetiology, and outcomes of postoperative anaemia and highlight prevention and management strategies. Further, we propose a novel framework to characterize postoperative anaemia as an acute organ injury (i.e., acute blood injury, anaemic subtype), thereby drawing attention to a condition that is frequently overlooked. Additionally, we discuss areas warranting further research, including risk stratification for patients at heightened risk for the development of postoperative anaemia and associated complications and determination of appropriate treatment strategies.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(23)00055-1
doi: 10.1016/j.bpa.2023.11.002
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Crispell EH
      type: Person
      first name: Ethan H
      last name: Crispell
      member of: Mayo Clinic Alix School of Medicine, Mayo Clinic, Minnesota, 200 1st St SW, Rochester, MN, 55906, USA. Electronic address: crispell.ethan@mayo.edu.
  slot:
    index: 2
    item: Trinh J
      type: Person
      first name: Jessica
      last name: Trinh
      member of: Mayo Clinic Alix School of Medicine, Mayo Clinic, Minnesota, 200 1st St SW, Rochester, MN, 55906, USA. Electronic address: trinh.jessica@mayo.edu.
  slot:
    index: 3
    item: Warner MA
      type: Person
      first name: Matthew A
      last name: Warner
      member of: Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Minnesota, 200 1st St SW, Rochester, MN, 55906, USA. Electronic address: warner.matthew@mayo.edu.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 486
ending page: 494
has place of publication: Netherlands
has primary subject term: D000740Q000453Q000628Q000175
has primary subject term: D011183Q000517Q000453Q000209
has subject term: D006801
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):486-494.
volume: 37

Does one unit really matter? Immunological effects of transfusion after universal leucodepletion.
pmid: 39764836
abstract: Patients with cancer who receive allogeneic red blood cell transfusions are at risk of adverse reactions of varying severity. One of these reactions is immunomodulation, also known as transfusion-related immunomodulation. With the exact mechanism of transfusion related immunomodulation being unclear, storage lesions (both the cellular and cytokine component) are considered a major contributor. Leucocytes are believed to be implicated in storage lesions and immunomodulation. However, the efficacy of leucodepletion in reducing immunomodulation is controversial. The theoretical link between these three interconnected events - storage lesions, immunomodulation and cancer progression remain controversial and poorly understood. This article summarizes the available evidence on efficacy of leucodepletion, storage lesions and transfusion related immunomodulation, while rationalizing the possible association between an immunomodulation triggering transfusion 'dose' in cancer patients and subsequent cancer recurrence.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(23)00053-8
doi: 10.1016/j.bpa.2023.10.004
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Muthukumar A
      type: Person
      first name: Arun
      last name: Muthukumar
      member of: Department of Anesthesiology and Perioperative Medicine, The University of Texas, MD Anderson Cancer Center, USA.
  slot:
    index: 2
    item: Guerra-Londono JJ
      type: Person
      first name: Juan Jose
      last name: Guerra-Londono
      member of: Department of Anesthesiology and Perioperative Medicine, The University of Texas, MD Anderson Cancer Center, USA; Anesthesiology and Surgical Oncology Research Group, USA.
  slot:
    index: 3
    item: Cata JP
      type: Person
      first name: Juan P
      last name: Cata
      member of: Department of Anesthesiology and Perioperative Medicine, The University of Texas, MD Anderson Cancer Center, USA; Anesthesiology and Surgical Oncology Research Group, USA. Electronic address: jcata@mdanderson.org.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 495
ending page: 502
has place of publication: Netherlands
has primary subject term: D009369Q000276Q000628
has subject term: D006801
has subject term: D056747
has subject term: D047589Q000379
has subject term: D017707Q000379Q000009
has subject term: D001793Q000379
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):495-502.
volume: 37

How low can you go: Restrictive transfusion strategies in major surgery and physiological triggers.
pmid: 39764834
abstract: Anemia and red blood cell transfusion are associated with adverse outcomes. Large randomized trials have demonstrated that restrictive transfusion strategies can safely reduce patient exposure to transfusion, forming a foundational pillar of patient blood management. The restrictive transfusion thresholds in these trials ranged from 7 to 8 g/dL for different populations and this variability is reflected in recent guideline recommendations for transfusion triggers. Such variability implies heterogeneity among populations with respect to the transfusion threshold for optimal outcomes. Individual variability (tolerance to anemia, risk of tissue hypoxia, risk of red blood cell transfusion) has not been addressed by population-based trials, supporting the argument for 'physiological transfusion triggers' indicative of inadequate organ perfusion. However, physiological triggers have only been assessed in small feasibility trials without convincing outcome data. This review summarizes data from recent transfusion trials and transfusion guidelines, and reviews potential physiological triggers which could further refine transfusion practices and minimize risks of tissue hypoxia and adverse outcomes.
rights: Copyright © 2023. Published by Elsevier Ltd.
has PII: S1521-6896(23)00058-7
doi: 10.1016/j.bpa.2023.11.005
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Hare GM
      type: Person
      first name: Gregory Mt
      last name: Hare
      member of: Department of Anesthesia, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
  slot:
    index: 2
    item: Alli A
      type: Person
      first name: Ahmad
      last name: Alli
      member of: Department of Anesthesia, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.
  slot:
    index: 3
    item: Jiang H
      type: Person
      first name: Helen
      last name: Jiang
      member of: Department of Anesthesia, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  slot:
    index: 4
    item: Mazer CD
      type: Person
      first name: C David
      last name: Mazer
      member of: Department of Anesthesia, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address: David.Mazer@unityhealth.to.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 477
ending page: 485
has place of publication: Netherlands
has primary subject term: D000740Q000628
has primary subject term: D001803Q000379Q000592Q000639
has subject term: D006801
has subject term: D017707Q000379Q000639Q000592
has subject term: D016032Q000379
has subject term: D017410Q000592
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):477-485.
volume: 37

Does patient blood management represent good value for money?
pmid: 39764838
abstract: Patient blood management is the umbrella term for a suite of initiatives designed to optimise blood product usage, minimise transfusion needs, and ensure appropriate and evidence-based transfusion practices. In this review we summarise published economic evaluations of patient blood management to determine whether they represent good value for money. We identified 54 economic evaluations of patient blood management, the majority of which had positive cost-effectiveness conclusions. In particular, anaemia management with ferric carboxymaltose, adopting a restrictive transfusion strategy, and the administration of tranexamic acid appear likely to be highly cost effective. Intraoperative cell salvage may be cost effective if used in patients at high risk of bleeding. Overall, patient blood management programmes are likely to reduce costs and improve patient outcomes in a wide range of patient populations. No identified evaluations included an assessment of the impact of patient blood management on preserving the blood supply.
rights: Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
has PII: S1521-6896(23)00057-5
doi: 10.1016/j.bpa.2023.11.004
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Irving A
      type: Person
      first name: Adam
      last name: Irving
      member of: Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Australia; Centre for Health Economics, Monash Business School, Monash University, Australia. Electronic address: adam.irving@monash.edu.
  slot:
    index: 2
    item: McQuilten ZK
      type: Person
      first name: Zoe K
      last name: McQuilten
      member of: Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Australia; Department of Clinical Haematology, Monash Health, Melbourne, Australia. Electronic address: zoe.mcquilten@monash.edu.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 511
ending page: 518
has place of publication: Netherlands
has primary subject term: D001803Q000379Q000191
has primary subject term: D003362Q000379
has subject term: D006801
has subject term: D000740Q000628Q000191
has subject term: D014148Q000008Q000191
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):511-518.
volume: 37

Preoperative iron therapy: Where are we?
pmid: 39764837
abstract: Preoperative anemia affects one-third of patients undergoing major surgery and is associated with worse perioperative and postoperative outcomes; including length of hospital stay, allogeneic blood transfusion, morbidity, and mortality. Iron deficiency is the most common cause of anemia, and associative data suggests that preoperative correction of iron deficiency anemia could improve postoperative patient outcomes. However, data from randomized controlled trials (RCTs) do not appear to support the routine use of iron therapy to treat preoperative anemia. We present a literature review of large RCTs examining the efficacy of preoperative intravenous iron. We discuss the observation that although preoperative intravenous iron treatment can increase hemoglobin concentration prior to surgery in certain patient groups, the data do not clarify whether there is a direct benefit to patients. We address that preoperative intravenous iron may not be a feasible option and highlight the need to explore the mechanism and management of iron deficiency anemia in surgical patients.
rights: Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
has PII: S1521-6896(23)00052-6
doi: 10.1016/j.bpa.2023.10.003
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: MacLean B
      type: Person
      first name: Beth
      last name: MacLean
      member of: School of Medicine, The University of Western Australia, Perth, Western Australia, Australia. Electronic address: Beth.MacLean@research.uwa.edu.au.
  slot:
    index: 2
    item: Weyand A
      type: Person
      first name: Angela
      last name: Weyand
      member of: Division of Hematology-Oncology, Department of Pediatrics, University of Michigan Medical School, Michigan, USA.
  slot:
    index: 3
    item: Lim J
      type: Person
      first name: Jayne
      last name: Lim
      member of: School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
  slot:
    index: 4
    item: Richards T
      type: Person
      first name: Toby
      last name: Richards
      member of: School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 503
ending page: 510
has place of publication: Netherlands
has primary subject term: D011300Q000379
has primary subject term: D018798Q000188
has primary subject term: D007501Q000008
has primary subject term: D016032Q000379
has subject term: D006801
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):503-510.
volume: 37

ESAs in perioperative anemia management: Who, what, how and why?
pmid: 39764839
abstract: Preoperative anemia is frequent and is associated with poor patient outcomes and higher transfusion rates. Perioperative blood transfusion is also associated with poor outcomes. These observations justify efforts to increase hemoglobin levels in anemic patients before surgeries with a moderate to high bleeding risk. Erythropoiesis-stimulating agents (ESAs) were developed in the 80s and are now widely used for the treatment of renal and cancer-related anemia. In the perioperative settings, ESAs were successfully proposed for preoperative blood donation programs in the 90s. Since then, substantial evidence has been available demonstrating that high-dose ESAs associated with iron (ideally intravenously), administered 3-4 weeks before surgery, increase perioperative hemoglobin levels and reduce the need for blood transfusion in some surgeries. Different strategies might be proposed ranging from a systematic treatment for all patients with hemoglobin below 13 g/dL (especially in orthopedic and cardiac surgeries) to a more personalized approach to anemia treatment (targeting anemia related to inflammation or renal insufficiency). ESAs might increase the risk of adverse events, including thromboembolism, and the benefit-risk ratio must be carefully weighted for high-risk patients (particularly for those undergoing cancer surgery). The cost-effectiveness of ESA use remains to be evaluated.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(23)00051-4
doi: 10.1016/j.bpa.2023.10.002
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lasocki S
      type: Person
      first name: Sigismond
      last name: Lasocki
      member of: Université d'Angers, Département Anesthésie Réanimation, CHU Angers, Angers, France; Université d'Angers, UMR CNRS 6015, Inserm U1083, Unité MitoVasc, Team Carme, Angers, France. Electronic address: Sigismond@lasocki.com.
  slot:
    index: 2
    item: Campfort M
      type: Person
      first name: Maëva
      last name: Campfort
      member of: Université d'Angers, Département Anesthésie Réanimation, CHU Angers, Angers, France; Université d'Angers, UMR CNRS 6015, Inserm U1083, Unité MitoVasc, Team Carme, Angers, France.
  slot:
    index: 3
    item: Leger M
      type: Person
      first name: Maxime
      last name: Leger
      member of: Université d'Angers, Département Anesthésie Réanimation, CHU Angers, Angers, France.
  slot:
    index: 4
    item: Rineau E
      type: Person
      first name: Emmanuel
      last name: Rineau
      member of: Université d'Angers, Département Anesthésie Réanimation, CHU Angers, Angers, France; Université d'Angers, UMR CNRS 6015, Inserm U1083, Unité MitoVasc, Team Carme, Angers, France.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 519
ending page: 526
has place of publication: Netherlands
has primary subject term: D000740Q000188Q000628
has primary subject term: D019990Q000379
has primary subject term: D006397Q000008Q000009
has subject term: D006801
has subject term: D001803Q000379
has subject term: D006454Q000378Q000032
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):519-526.
volume: 37

http://rdf.ncbi.nlm.nih.gov/pubmed/39764840
pmid: 39764840
abstract: Goal-directed administration of blood components including red cells, platelets, plasma, and factor concentrates plays a critical role in the management of intraoperative coagulopathy. Increasingly commonly used, purified and recombinant factor concentrates are being recognized for their logistical advantages and potentially superior efficacy. Three- and four-factor prothrombin concentrates, fibrinogen concentrates and activated factor VII have an evolving evidence base relative to frozen plasma and cryoprecipitate. This review discusses these compounds, compares them to conventional blood products, discusses the trial data supporting their use, and reviews indications for intraoperative transfusion based on point-of-care testing and conventional laboratory results. While factor concentrates have become an increasingly popular option for treating acquired factor deficiency in surgical patients, evidence is evolving and clinical trial data in one surgical patient population may not be transferable to another. High quality clinical studies will help optimize management of coagulopathy and improve patient outcomes while decreasing any associated risks.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S1521-6896(23)00056-3
doi: 10.1016/j.bpa.2023.11.003
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Zabida A
      type: Person
      first name: Amir
      last name: Zabida
      member of: Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address: Amir.Zabida@uhn.ca.
  slot:
    index: 2
    item: Bartoszko J
      type: Person
      first name: Justyna
      last name: Bartoszko
      member of: Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto, Ontario, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address: research.anesthesia@utoronto.ca.
  slot:
    index: 3
    item: Karkouti K
      type: Person
      first name: Keyvan
      last name: Karkouti
      member of: Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto, Ontario, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
created: 2023-12-1T00:00
date last updated: 2025-01-07
issued: 2023-12
dp: 2023 Dec
created: 2025-1-7T10:56
e ISSN: 1878-1608
has issn l: 1753-3740
issue: 4
has NLM journal title abbreviation: Best Pract Res Clin Anaesthesiol
publication name: Best practice & research. Clinical anaesthesiology
language: eng
has national library of medicine journal id: 101121446
derived from: NLM
starting page: 527
ending page: 536
has place of publication: Netherlands
has primary subject term: D001778Q000188
has primary subject term: D011994Q000008
has primary subject term: D005340Q000008
has primary subject term: D001779Q000008Q000627
has primary subject term: D015942Q000008
has subject term: D006801
has subject term: D007430Q000379
source: Best Pract Res Clin Anaesthesiol. 2023-12;37(4):527-536.
title: Magic in a bottle? A Focused review of factor concentrates for the intraoperative treatment of acquired coagulopathy - Fibrinogen concentrate, prothrombin complex concentrate, and recombinant activated factor VII.
volume: 37

Gender inequality: policy responses to employment and education in BRICS countries.
pmid: 39764841
abstract: This study assesses gender inequality in education and employment in BRICS (Brazil, Russia, India, China, and South Africa) countries between the 2000 and 2021, using data from the World Bank database. A descriptive data analysis was carried out as well as graphical representations to compare among countries. The results showed that that female education achieved significant success, especially at secondary and tertiary levels, through specific policies including financial support and affirmative actions. Brazil and Russia maintained an increasingly higher enrollment at the secondary level of education. In contrast, China recorded very rapid growth in tertiary enrollments, reaching over 92% enrolment of females. History, poverty, and social pressures were identified as systemic barriers in the enrollment of girls to school in India and South Africa. This study indicate that even when gains are achieved on the educational front, translating them into gains in terms of equality in employment proves difficult. Secondly, the unemployment rates among females in countries such as Brazil and South Africa are higher, reflecting more significant socio-economic problems. This calls for more vigorous policy responses toward gender inequality within the labour market through labour reforms, job creation policies, and specific support to women's employment in the informal sector in the BRICS countries.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 88-96
doi: 10.29063/ajrh2024/v28i12.10
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: HonglingYi H
      type: Person
      first name: HonglingYi
      last name: HonglingYi
      member of: Changchun Sci-Tech University, JiLin ChangChun 130600, China.
  slot:
    index: 2
    item: Wang G
      type: Person
      first name: Gang
      last name: Wang
      member of: Changchun Sci-Tech University, JiLin ChangChun 130600, China.
  slot:
    index: 3
    item: Feng J
      type: Person
      first name: Jie
      last name: Feng
      member of: Changchun Sci-Tech University, JiLin ChangChun 130600, China.
created: 2025-1-7T17:11
date last updated: 2025-01-07
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-7T10:56
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Cette étude évalue les inégalités entre les sexes dans l'éducation et l'emploi dans les pays BRICS (Brésil, Russie, Inde, Chine et Afrique du Sud) entre 2000 et 2021, à l'aide des données de la base de données de la Banque mondiale. Une analyse descriptive des données a été réalisée ainsi que des représentations graphiques pour comparer les pays. Les résultats ont montré que l'éducation des femmes a obtenu des succès significatifs, en particulier aux niveaux secondaire et supérieur, grâce à des politiques spécifiques comprenant un soutien financier et des actions positives. Le Brésil et la Russie ont maintenu un taux de scolarisation de plus en plus élevé dans l’enseignement secondaire. En revanche, la Chine a enregistré une croissance très rapide des inscriptions dans l’enseignement supérieur, atteignant plus de 92 % d’inscriptions de femmes. L’histoire, la pauvreté et les pressions sociales ont été identifiées comme des obstacles systémiques à la scolarisation des filles en Inde et en Afrique du Sud. Cette étude indique que même lorsque des progrès sont réalisés sur le plan éducatif, il s'avère difficile de les traduire en gains en termes d'égalité dans l'emploi. Deuxièmement, les taux de chômage des femmes dans des pays comme le Brésil et l’Afrique du Sud sont plus élevés, ce qui reflète des problèmes socio-économiques plus importants. Cela nécessite des réponses politiques plus vigoureuses à l'inégalité entre les sexes sur le marché du travail à travers des réformes du travail, des politiques de création d'emplois et un soutien spécifique à l'emploi des femmes dans le secteur informel dans les pays BRICS.
derived from: NLM
starting page: 88
ending page: 96
has place of publication: Nigeria
has primary subject term: D004651Q000706
has primary subject term: http://id.nlm.nih.gov/mesh/D000084803
has primary subject term: D012959
has subject term: D006801
has subject term: D005260
has subject term: D013019
has subject term: D001938
has subject term: D007194
has subject term: D012426
has subject term: D002681
has subject term: D008297
has subject term: D004522
source: Afr J Reprod Health. 2024-12-31;28(12):88-96.
volume: 28

West Nile Neuroinvasive Disease: Case Series and Review of the Literature.
pmid: 39764842
abstract: West Nile virus (WNV), although underdiagnosed, is the most common mosquito-borne disease and the second most common cause of viral encephalitis in the United States. Fewer than 1% of those infected develop neuroinvasive disease.We present a cluster of 3 cases of neuroinvasive WNV that occurred between August and September 2023 and a review of the literature for neurologic involvement with this virus.Sunrise Electronic Health Record; PubMed; Google; Division of Infectious Disease Diagnostics, Northwell Health Laboratories, Little Neck, NY.The patients in all 3 cases were admitted with acute encephalopathy and other neurologic impairment. All 3 patients had a serum serologic diagnosis consistent with WNV. However, only one of 3 of the patients underwent a lumbar puncture with cerebrospinal fluid confirmation of WNV.Clinical and laboratory guidelines have been described for the diagnosis of neuroinvasive WNV infection. This is especially important in patients who do not have cerebrospinal fluid confirmation.WNV is underdiagnosed. Furthermore, although neuroinvasive WNV infection is uncommon, this diagnosis should be considered in patients presenting with abnormal neurologic signs and symptoms during the summer months in geographic areas where potential transmission is of concern.
rights: Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 00045391-202502000-00001
doi: 10.1097/MJT.0000000000001869
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Alter R
      type: Person
      first name: Rachel
      last name: Alter
      member of: Department of Medicine, Long Island Jewish Forest Hills (Northwell Health), Forest Hills, NY.
  slot:
    index: 2
    item: Juretschko S
      type: Person
      first name: Stefan
      last name: Juretschko
      member of: Division of Infectious Disease Diagnostics, Northwell Health Laboratories, Little Neck, NY; and.
  slot:
    index: 3
    item: Smith MA
      type: Person
      first name: Miriam A
      last name: Smith
      member of: Department of Medicine, Long Island Jewish Forest Hills (Northwell Health), Forest Hills, NY.Dayton and Karen Brown Division of Infectious Diseases, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Manhasset, NY.
created: 2025-1-7T18:20
date last updated: 2025-01-07
created: 2025-1-7T12:13
e ISSN: 1536-3686
has issn l: 1075-2765
issue: 1
has NLM journal title abbreviation: Am J Ther
publication name: American journal of therapeutics
language: eng
has national library of medicine journal id: 9441347
derived from: NLM
starting page: e1
ending page: e4
has place of publication: United States
has primary subject term: D014901Q000175Q000453Q000134
has primary subject term: D014902Q000302
has subject term: D006801
source: Am J Ther. ;32(1):e1-e4.
volume: 32

Artificial Oxygen Carriers Save Lives in Expanded Access Use: Three Cases when Blood Was Not an Option.
pmid: 39764843
abstract: Sickle cell patients may develop a multitude of antibodies and experience life-threatening events with transfusion such as hyperhemolysis syndrome or delayed hemolytic transfusion reaction. Further transfusion may not be possible in such cases.When conventional blood products are not available for transfusion yet the patient requires additional oxygen-carrying support, artificial oxygen carriers may be required. However, there are no such FDA-approved products available.Emergency investigational new drug applications for a polymerized hemoglobin-based oxygen carrier (HBOC-201, Hemopure) were completed, and Expanded Access use was granted for these patients. HBOC-201 is an investigational bovine hemoglobin-based oxygen carrier. Herein, we report how acute resuscitation with HBOC-201 was potentially life saving while waiting for supportive therapy, erythropoietin, and/or immune modulatory drugs to take effect in all 3 patients.
rights: Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
has PII: 00045391-202502000-00004
doi: 10.1097/MJT.0000000000001777
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Mei ZW
      type: Person
      first name: Zhen W
      last name: Mei
      member of: Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  slot:
    index: 2
    item: Raval JS
      type: Person
      first name: Jay S
      last name: Raval
      member of: Transfusion Medicine and Therapeutic Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM.
  slot:
    index: 3
    item: Arnall J
      type: Person
      first name: Justin
      last name: Arnall
      member of: Atrium Health, Charlotte, NC.
  slot:
    index: 4
    item: Hwang SH
      type: Person
      first name: Sophia H
      last name: Hwang
      member of: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  slot:
    index: 5
    item: Rodberg K
      type: Person
      first name: Karen
      last name: Rodberg
      member of: American Red Cross, Los Angeles, CA.
  slot:
    index: 6
    item: Quon D
      type: Person
      first name: Doris
      last name: Quon
      member of: Orthopaedic Hemophilia Treatment Center, Los Angeles, CA; and.
  slot:
    index: 7
    item: Ward DC
      type: Person
      first name: Dawn C
      last name: Ward
      member of: Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  slot:
    index: 8
    item: Ziman A
      type: Person
      first name: Alyssa
      last name: Ziman
      member of: Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  slot:
    index: 9
    item: McGonigle AM
      type: Person
      first name: Andrea M
      last name: McGonigle
      member of: Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  slot:
    index: 10
    item: Jahr JS
      type: Person
      first name: Jonathan S
      last name: Jahr
      member of: Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
created: 2025-1-7T18:20
date last updated: 2025-01-07
created: 2025-1-7T12:13
e ISSN: 1536-3686
has issn l: 1075-2765
issue: 1
has NLM journal title abbreviation: Am J Ther
publication name: American journal of therapeutics
language: eng
has national library of medicine journal id: 9441347
derived from: NLM
starting page: e30
ending page: e34
has place of publication: United States
has primary subject term: D001802Q000008Q000627
has primary subject term: D006454Q000032Q000008
has subject term: D006801
has subject term: D000755Q000628
has subject term: D057176
source: Am J Ther. ;32(1):e30-e34.
volume: 32

An Investigation Into the Clinical Characteristics and Management Strategies for Patients With Lymphoma and Concomitant COVID-19.
pmid: 39764846
has PII: 00045391-202502000-00008
doi: 10.1097/MJT.0000000000001783
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Liu H
      type: Person
      first name: Hu
      last name: Liu
      member of: Department of Lymphatic Oncology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
  slot:
    index: 2
    item: Wang GQ
      type: Person
      first name: Gui-Qin
      last name: Wang
      member of: Department of Lymphatic Oncology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
  slot:
    index: 3
    item: Wang L
      type: Person
      first name: Liao
      last name: Wang
      member of: Department of Lymphatic Oncology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
  slot:
    index: 4
    item: Gao F
      type: Person
      first name: Fang
      last name: Gao
      member of: Department of Lymphatic Oncology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
  slot:
    index: 5
    item: Hou SL
      type: Person
      first name: Shu-Ling
      last name: Hou
      member of: Department of Lymphatic Oncology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
created: 2025-1-7T18:20
date last updated: 2025-01-07
created: 2025-1-7T12:13
e ISSN: 1536-3686
has issn l: 1075-2765
issue: 1
has NLM journal title abbreviation: Am J Ther
publication name: American journal of therapeutics
language: eng
has national library of medicine journal id: 9441347
derived from: NLM
starting page: e43
ending page: e47
has place of publication: United States
source: Am J Ther. ;32(1):e43-e47.
volume: 32

Noninferiority Study of the Effects of Remimazolam Tosylate Versus Propofol on Cognitive Function in Elderly Patients Undergoing Elective Outpatient Colonoscopy.
pmid: 39764845
has PII: 00045391-202502000-00007
doi: 10.1097/MJT.0000000000001781
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Li H
      type: Person
      first name: Hang
      last name: Li
      member of: Department of Anesthesiology, Ningbo Hangzhou Bay Hospital, Shanghai Jiao Tong University School of Medicine, Ningbo, China.
  slot:
    index: 2
    item: Duan ZY
      type: Person
      first name: Ze-Yu
      last name: Duan
      member of: Department of Anesthesiology, Ningbo Hangzhou Bay Hospital, Shanghai Jiao Tong University School of Medicine, Ningbo, China.
  slot:
    index: 3
    item: Mo YP
      type: Person
      first name: Ye-Ping
      last name: Mo
      member of: Department of Anesthesiology, Ningbo Hangzhou Bay Hospital, Shanghai Jiao Tong University School of Medicine, Ningbo, China.
  slot:
    index: 4
    item: Yu WF
      type: Person
      first name: Wei-Feng
      last name: Yu
      member of: Department of Anesthesiology, Shanghai Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 5
    item: Chen YM
      type: Person
      first name: Yong-Ming
      last name: Chen
      member of: Department of Anesthesiology, Ningbo Hangzhou Bay Hospital, Shanghai Jiao Tong University School of Medicine, Ningbo, China.Department of Anesthesiology, Shanghai Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.
created: 2025-1-7T18:20
date last updated: 2025-01-07
created: 2025-1-7T12:13
e ISSN: 1536-3686
has issn l: 1075-2765
issue: 1
has NLM journal title abbreviation: Am J Ther
publication name: American journal of therapeutics
language: eng
has national library of medicine journal id: 9441347
derived from: NLM
starting page: e40
ending page: e43
has place of publication: United States
source: Am J Ther. ;32(1):e40-e43.
volume: 32

Informed Consent to Psychedelic Medicine.
pmid: 39764844
has PII: 00045391-202502000-00006
doi: 10.1097/MJT.0000000000001782
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Tabaac BJ
      type: Person
      first name: Burton J
      last name: Tabaac
      member of: University of Nevada, Reno School of Medicine, Reno, NV.Department of Neurology, Carson Tahoe Health, Carson City, NV.
  slot:
    index: 2
    item: Feldman M
      type: Person
      first name: Michelle
      last name: Feldman
      member of: Stanford University School of Medicine, Palo Alto, CA.Multidisciplinary Association for Psychedelic Studies, San Jose, CA.
  slot:
    index: 3
    item: Muir OS
      type: Person
      first name: Owen S
      last name: Muir
      member of: Fermata Health, Brooklyn, NY; and.Acacia Clinics, Sunnyvale, CA.
created: 2025-1-7T18:20
date last updated: 2025-01-07
created: 2025-1-7T12:13
e ISSN: 1536-3686
has issn l: 1075-2765
issue: 1
has NLM journal title abbreviation: Am J Ther
publication name: American journal of therapeutics
language: eng
has national library of medicine journal id: 9441347
derived from: NLM
starting page: e37
ending page: e39
has place of publication: United States
source: Am J Ther. ;32(1):e37-e39.
volume: 32

Enhancing the Evidence Base for the Efficacy of Nirmatrelvir-Ritonavir in Preventing COVID-19 Hospitalization and Mortality: A Call for Comprehensive Research Strategies.
pmid: 39764847
has PII: 00045391-202502000-00009
doi: 10.1097/MJT.0000000000001790
created: 2025-1-7T18:20
date last updated: 2025-01-07
created: 2025-1-7T12:13
e ISSN: 1536-3686
has issn l: 1075-2765
issue: 1
has NLM journal title abbreviation: Am J Ther
publication name: American journal of therapeutics
language: eng
has national library of medicine journal id: 9441347
derived from: NLM
starting page: e47
ending page: e48
has place of publication: United States
source: Am J Ther. ;32(1):e47-e48.
volume: 32

Motion detection: Specific thalamocortical connections revealed.
pmid: 39765209
abstract: Inferring the direction of image motion is an important component of visual processing. A study with in vivo dual electrophysiological recording now reveals that the sensitivity of visual cortical neurons to the direction of motion is established by specific neural connections from the visual thalamus.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01559-8
doi: 10.1016/j.cub.2024.11.019
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Matsumoto A
      type: Person
      first name: Akihiro
      last name: Matsumoto
      member of: Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Japan; Graduate Institute for Advanced Studies, Sokendai, Hayama, Japan.
  slot:
    index: 2
    item: Yonehara K
      type: Person
      first name: Keisuke
      last name: Yonehara
      member of: Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Japan; Graduate Institute for Advanced Studies, Sokendai, Hayama, Japan. Electronic address: keisuke.yonehara@nig.ac.jp.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R11
ending page: R13
has place of publication: England
has primary subject term: D014793Q000502
has primary subject term: D009039Q000502
has primary subject term: D013788Q000502
has subject term: D000818
has subject term: D009474Q000502
has subject term: D014795Q000502
source: Curr Biol. 2025-01-06;35(1):R11-R13.
volume: 35

Thermoregulation: When cooling cools and heating heats.
pmid: 39765210
abstract: Body temperature regulation in endotherms requires warming the body when ambient temperatures are low and cooling the body when they are high. Now, neural circuitry that can achieve the opposite has been identified - a phenomenon called thermoregulatory inversion.
rights: Published by Elsevier Inc.
has PII: S0960-9822(24)01572-0
doi: 10.1016/j.cub.2024.11.031
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Piñol RA
      type: Person
      first name: Ramón A
      last name: Piñol
      member of: Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ramon.pinol@nih.gov.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R13
ending page: R16
has place of publication: England
has primary subject term: D001833Q000502
has subject term: D000818
has subject term: D003080
has subject term: D006358
has subject term: D006801
source: Curr Biol. 2025-01-06;35(1):R13-R16.
volume: 35

Dormancy: Metabolite pools prime the cyanobacterial dormancy-resuscitation switch.
pmid: 39765211
abstract: Non-N2-fixing cyanobacteria enter a state of dormancy when fixed nitrogen becomes limiting. Resuscitation from this state involves a complex program of events. A new study reveals how the dormancy-resuscitation switch is governed by metabolite-level control of glucose-6-phosphate dehydrogenase activity.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01557-4
doi: 10.1016/j.cub.2024.11.017
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Sawers RG
      type: Person
      first name: R Gary
      last name: Sawers
      member of: Institute for Microbiology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany. Electronic address: gary.sawers@mikrobiologie.uni-halle.de.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R16
ending page: R18
has place of publication: England
has primary subject term: D000458Q000378Q000502Q000235
has subject term: D005954Q000378Q000235
has subject term: D009586
has subject term: D009584Q000378
source: Curr Biol. 2025-01-06;35(1):R16-R18.
volume: 35

Visual simulation: Catching a glimpse of what's to come.
pmid: 39765213
abstract: Are humans unique in using visual simulation to see beyond the 'here and now' in the mind's eye? A new study has now shown that monkeys can employ simulation to anticipate how physical events will unfold.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01558-6
doi: 10.1016/j.cub.2024.11.018
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Fischer J
      type: Person
      first name: Jason
      last name: Fischer
      member of: Faculty of Psychology and Educational Sciences, University of Coimbra, 3000-115 Coimbra, Portugal. Electronic address: jason.fischer@fpce.uc.pt.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R21
ending page: R23
has place of publication: England
has primary subject term: D014796Q000502
has subject term: D000818
has subject term: D006801
source: Curr Biol. 2025-01-06;35(1):R21-R23.
volume: 35

Predator avoidance: Threat learning in week-old zebrafish.
pmid: 39765212
abstract: As soon as they can move, animals must learn to avoid potential predators. New research demonstrates that larval zebrafish can quickly learn to avoid specific predator-like robots in their first week of life, through coordinated noradrenergic and forebrain activity.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01516-1
doi: 10.1016/j.cub.2024.11.009
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Martin KA
      type: Person
      first name: Kathleen A
      last name: Martin
      member of: Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: kam023@ucsd.edu.
  slot:
    index: 2
    item: Lovett-Barron M
      type: Person
      first name: Matthew
      last name: Lovett-Barron
      member of: Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: mlb@ucsd.edu.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R19
ending page: R21
has place of publication: England
has primary subject term: D015027Q000502
has primary subject term: D001362Q000502
has primary subject term: D011235Q000502
has subject term: D000818
has subject term: D007814Q000502Q000254
source: Curr Biol. 2025-01-06;35(1):R19-R21.
volume: 35

Evolution: An Ediacaran ecdysozoan.
pmid: 39765215
abstract: A new study describes a fossilized ecdysozoan from Ediacaran rocks, extending the body fossil record for this hyper-diverse group and emphasizing the pivotal insights provided by Ediacaran fossils in documenting the early evolutionary history of major animal clades.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01571-9
doi: 10.1016/j.cub.2024.11.030
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Liu AG
      type: Person
      first name: Alexander G
      last name: Liu
      member of: Department of Earth Sciences, University of Cambridge, Cambridge, UK. Electronic address: agscl2@cam.ac.uk.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R26
ending page: R28
has place of publication: England
has primary subject term: D005580Q000033
has primary subject term: D005075
has subject term: D000818
has subject term: D007448Q000145Q000033
has subject term: D010802
source: Curr Biol. 2025-01-06;35(1):R26-R28.
volume: 35

Human evolution: The lonely Neanderthal?
pmid: 39765216
abstract: A recently excavated Neanderthal skeleton from southern France has yielded DNA from a distinct lineage, different from other late Neanderthals. This suggests Neanderthals expanded and diversified about 120,000 years ago, and some of that diversity persisted in Europe until near the time of their extinction.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01584-7
doi: 10.1016/j.cub.2024.11.043
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Stringer C
      type: Person
      first name: Chris
      last name: Stringer
      member of: Centre for Human Evolution Research, The Natural History Museum, London, UK. Electronic address: c.stringer@nhm.ac.uk.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R29
ending page: R31
has place of publication: England
has primary subject term: D059125Q000235
has primary subject term: D005580
has primary subject term: D005075
has subject term: D000818
has subject term: D006801
has subject term: D005602
source: Curr Biol. 2025-01-06;35(1):R29-R31.
volume: 35

Maria A. Nieves-Colón.
pmid: 39765218
has PII: S0960-9822(24)01635-X
doi: 10.1016/j.cub.2024.11.068
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Nieves-Colón MA
      type: Person
      first name: Maria A
      last name: Nieves-Colón
      member of: Department of Anthropology, University of Minnesota, Minneapolis, MN, USA. Electronic address: mnievesc@umn.edu.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
pg: R6
has place of publication: England
source: Curr Biol. 2025-01-06;35(1):R6.
volume: 35

Evolution and ecology of anti-defence systems in phages and plasmids.
pmid: 39765217
abstract: Prokaryotes (Bacteria and Archaea) encode a highly diversified arsenal of defence systems that protect them against mobile genetic elements, such as phages and plasmids. In turn, mobile genetic elements encode anti-defence systems that allow them to escape the activity of these defence systems. This has resulted in an evolutionary arms race in which defence systems and anti-defence systems evolve and adapt continuously, driving intriguing innovation and enormous diversification on both sides. Over 150 prokaryotic defence systems have been identified to date. Anti-defence systems are known for only a subset of these, but more are being discovered at a steady rate. Despite an increasing understanding of the highly diverse molecular mechanisms of anti-defence systems, their diverse evolutionary origins, the selective pressures they are subjected to, and their ecological importance and implications often remain obscure. In this review, we describe the diverse strategies that phage and plasmid anti-defence systems employ to escape host defence systems. We explore the evolutionary origins of anti-defence systems and describe different factors that exert selective pressure, affecting their maintenance and diversification. We describe how, in turn, defence systems themselves evolved to act upon anti-defence mechanisms, thereby adding a new layer to the co-evolutionary battle between prokaryotes and their mobile genetic elements. We discuss how the continuous selective pressures found in dynamic microbial communities promote the retention and diversification of these anti-defence systems. Finally, we consider the ecological implications for both hosts and their mobile genetic elements, noting how the balance of defence and anti-defence strategies can shape microbial community composition, influence horizontal gene transfer, and impact ecosystem stability.
rights: Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01574-4
doi: 10.1016/j.cub.2024.11.033
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Niault T
      type: Person
      first name: Theophile
      last name: Niault
      member of: Laboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, The Netherlands.
  slot:
    index: 2
    item: van Houte S
      type: Person
      first name: Stineke
      last name: van Houte
      member of: Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn TR10 9FE, UK.
  slot:
    index: 3
    item: Westra E
      type: Person
      first name: Edze
      last name: Westra
      member of: Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn TR10 9FE, UK. Electronic address: e.r.westra@exeter.ac.uk.
  slot:
    index: 4
    item: Swarts DC
      type: Person
      first name: Daan C
      last name: Swarts
      member of: Laboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, The Netherlands. Electronic address: daan.swarts@wur.nl.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R32
ending page: R44
has place of publication: England
has primary subject term: D010957Q000235
has primary subject term: D001435Q000235Q000502
has primary subject term: D001419Q000821Q000235
has subject term: D001105Q000235Q000821
has subject term: D019143
has subject term: D005075
has subject term: D020071
source: Curr Biol. 2025-01-06;35(1):R32-R44.
volume: 35

Clonal raider ants.
pmid: 39765219
abstract: Daniel Kronauer introduces the clonal raider ant, a unique species of ant that has no queens and where workers lay asexually produced eggs that develop into new workers.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01576-8
doi: 10.1016/j.cub.2024.11.034
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kronauer DJC
      type: Person
      first name: Daniel J C
      last name: Kronauer
      member of: Laboratory of Social Evolution and Behavior and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: dkronauer@rockefeller.edu.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R7
ending page: R8
has place of publication: England
has primary subject term: D001000Q000502
has subject term: D000818
has subject term: D005260
has subject term: D012100
source: Curr Biol. 2025-01-06;35(1):R7-R8.
volume: 35

Human evolution: Run Lucy, run!
pmid: 39765220
abstract: Endurance running is thought as critical for the evolutionary success of hominins. A new study analysing the running skills of the famous 'Lucy' - Australopithecus afarensis - finds that they performed poorer than modern humans, suggesting that key features of the human body plan evolved specifically to improve running performance.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0960-9822(24)01585-9
doi: 10.1016/j.cub.2024.11.044
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Wiseman AL
      type: Person
      first name: Ashleigh L
      last name: Wiseman
      member of: Department of Anthropology, University College London, London, UK; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK. Electronic address: a.wiseman@ucl.ac.uk.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T18:17
e ISSN: 1879-0445
has issn l: 0960-9822
issue: 1
has NLM journal title abbreviation: Curr Biol
publication name: Current biology : CB
language: eng
has national library of medicine journal id: 9107782
derived from: NLM
starting page: R9
ending page: R11
has place of publication: England
has primary subject term: D005075
has primary subject term: D012420Q000502
has primary subject term: D015186Q000033Q000502
has subject term: D006801
has subject term: D000818
has subject term: D010807Q000502
source: Curr Biol. 2025-01-06;35(1):R9-R11.
volume: 35

Impact of Robotic Artificial Urinary Sphincter Implantation in Female Patients on Quality of Life and Patient-reported Outcomes.
pmid: 39765372
abstract: Artificial urinary sphincter (AUS) is commonly used in France in female patients with stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD). However, it has never been assessed using patient-reported outcomes. This study aimed to evaluate the functional outcomes of robotic AUS implantation using validated questionnaires.The data from female patients who underwent robotic AUS implantation at a single academic center between 2014 and 2023 were collected prospectively. Preoperatively, all patients filled out a Urinary Symptoms Profile (USP) questionnaire, and the International Consultation Incontinence Questionnaire Short Form (ICIQ-SF). These were repeated at 3 mo postoperatively and annually along with a Patient Global Impression of Improvement (PGII) score. Quality of life was assessed using question 5 of the ICIQ-SF.Over the study period, 101 robotic female AUS implantation cases were performed by three surgeons. The median patient age was 66 yr (interquartile range: 53-73), and 86.9% had a history of previous SUI surgery. In our cohort, 12 patients had neurogenic SUI (11.8%). In terms of complications, there were 16 intraoperative (15.8%) and 26 postoperative (25.7%) complications, all of Clavien grade 1 or 2 except seven of Clavien grade 3B (major complication rate: 6.8%). All patient-reported outcomes improved significantly at 3 mo. The USP SUI subscore decreased from 7.3 preoperatively to 0.8 at 3 mo (/9; p < 0.0001), the USP overactive bladder subscore decreased from 12.6 to 5.1 (/21; p < 0.0001), and the ICIQ-SF decreased from 16.5 to 3.1 (/21; p < 0.0001). Quality of life improved, with the ICIQ-QoL decreasing from 8.8 preoperatively to 0.9 at 3 mo (/10; p < 0.0001). The 3-mo PGII score was 1/7 (very much improved) in 79 patients (78.8%).Robot-assisted AUS implantation in female patients has low morbidity and improves the patient-reported outcomes and quality of life of female patients with SUI due to ISD.This study represents the lar[cell cut: 2740 characters, first 2000 kept]
rights: Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
has PII: S2405-4569(24)00261-X
doi: 10.1016/j.euf.2024.12.002
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Dubois A
      type: Person
      first name: Alexandre
      last name: Dubois
      member of: Department of Urology, University of Rennes, Rennes, France. Electronic address: alexandreduboisint@gmail.com.
  slot:
    index: 2
    item: Haudebert C
      type: Person
      first name: Camille
      last name: Haudebert
      member of: Department of Urology, University of Rennes, Rennes, France.
  slot:
    index: 3
    item: Richard C
      type: Person
      first name: Claire
      last name: Richard
      member of: Department of Urology, University of Rennes, Rennes, France.
  slot:
    index: 4
    item: Penafiel J
      type: Person
      first name: Juan
      last name: Penafiel
      member of: Department of Urology, University of Rennes, Rennes, France.
  slot:
    index: 5
    item: Freton L
      type: Person
      first name: Lucas
      last name: Freton
      member of: Department of Urology, University of Rennes, Rennes, France.
  slot:
    index: 6
    item: Voiry C
      type: Person
      first name: Caroline
      last name: Voiry
      member of: Department of Physical Medicine and Rehabilitation, University of Rennes, Rennes, France.
  slot:
    index: 7
    item: Samson E
      type: Person
      first name: Emmanuelle
      last name: Samson
      member of: Department of Physical Medicine and Rehabilitation, University of Rennes, Rennes, France.
  slot:
    index: 8
    item: Manunta A
      type: Person
      first name: Andrea
      last name: Manunta
      member of: Department of Urology, University of Rennes, Rennes, France; Department of Urology, Clinique Mutualiste La Sagesse, Rennes, France.
  slot:
    index: 9
    item: Hascoet J
      type: Person
      first name: Juliette
      last name: Hascoet
      member of: Department of Urology, University of Rennes, Rennes, France.
  slot:
    index: 10
    item: Peyronnet B
      type: Person
      first name: Benoit
      last name: Peyronnet
      member of: Department of Urology, University of Rennes, Rennes, France.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:53
e ISSN: 2405-4569
has issn l: 2405-4569
has NLM journal title abbreviation: Eur Urol Focus
publication name: European urology focus
language: eng
has national library of medicine journal id: 101665661
derived from: NLM
has place of publication: Netherlands
source: Eur Urol Focus. 2025-01-06;():.

Association between the number of remaining teeth and pseudarthrosis after lumbar interbody fusion: A retrospective cohort study.
pmid: 39765395
abstract: Pseudarthrosis is a major complication after posterior lumbar interbody fusion (PLIF) and transforaminal interbody fusion (TLIF), and its risk factors need to be identified. This study aimed to investigate the relationship between the number of remaining teeth (NRT) and pseudarthrosis.NRT, preoperative bone density of the proximal femur (percentages of young adult mean; % YAM), and preoperative procollagen type 1 N-terminal propeptide (P1NP) (μg/L) were retrospectively investigated in 63 patients (24 male and 39 female, mean age: 71.2 years, mean follow-up: 49.1 months) who underwent single-level PLIF/TLIF (L3/4, L4/5, L5/S1). Fusion status was analyzed on computed tomography (CT) scan at 24 months after surgery.Pseudarthrosis was significantly more frequent in the NRT ≤10 group than in the NRT ≥11 group (p < 0.05). Compared with the fusion group, the pseudarthrosis group had significantly higher population of males and lower % YAM. Logistic regression analysis was performed with the following variable combination models; Model 1: age, % YAM, NRT; Model 2: P1NP, % YAM, NRT; Model 3: sex, % YAM, NRT. NRT ≤10 was associated with pseudoarthrosis in all models (model 1: 95 % confidence interval (CI): 1.81-25.14, odds ratios (ORs): 6.74, p < 0.01, model 2; 95 % CI: 1.57-30.54, ORs: 5.88, p = 0.01, model 3; 95 % CI: 1.95-39.02, ORs: 7.07, p < 0.01). Sex was associated with pseudarthrosis in model 3 (95 % CI: 1.23-16.92, ORs: 4.30, p = 0.02).Small NRT was found to be a risk factor of pseudarthrosis after lumbar interbody fusion.
rights: Copyright © 2024 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
has PII: S0949-2658(24)00272-0
doi: 10.1016/j.jos.2024.12.003
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Ura K
      type: Person
      first name: Katsuro
      last name: Ura
      member of: Department of Orthopedic Surgery, Otaru General Hospital, 1-1-1, Wakamatsu, Otaru, Hokkaido, 047-8550, Japan.
  slot:
    index: 2
    item: Hiratsuka S
      type: Person
      first name: Shigeto
      last name: Hiratsuka
      member of: Department of Orthopedic Surgery, Otaru General Hospital, 1-1-1, Wakamatsu, Otaru, Hokkaido, 047-8550, Japan; Department of Orthopedic Surgery, Sapporo Hospital, 16-1, N5E11, Sapporo, Hokkaido, 065-0005, Japan.
  slot:
    index: 3
    item: Koizumi K
      type: Person
      first name: Koyo
      last name: Koizumi
      member of: Department of Orthopedic Surgery, Otaru General Hospital, 1-1-1, Wakamatsu, Otaru, Hokkaido, 047-8550, Japan.
  slot:
    index: 4
    item: Nakashita N
      type: Person
      first name: Namito
      last name: Nakashita
      member of: Department of Orthopedic Surgery, Otaru General Hospital, 1-1-1, Wakamatsu, Otaru, Hokkaido, 047-8550, Japan.
  slot:
    index: 5
    item: Hamasaki M
      type: Person
      first name: Masanari
      last name: Hamasaki
      member of: Department of Orthopedic Surgery, Otaru General Hospital, 1-1-1, Wakamatsu, Otaru, Hokkaido, 047-8550, Japan.
  slot:
    index: 6
    item: Tsukuda Y
      type: Person
      first name: Yukinori
      last name: Tsukuda
      member of: Department of Orthopedic Surgery, Otaru General Hospital, 1-1-1, Wakamatsu, Otaru, Hokkaido, 047-8550, Japan.
  slot:
    index: 7
    item: Yamada K
      type: Person
      first name: Katsuhisa
      last name: Yamada
      member of: Department of Orthopedic Surgery, Faculty of Medicine and Graduate of Medicine, Hokkaido University, N15W7, Sapporo, Hokkaido, 065-0024, Japan. Electronic address: yka2q@pop.med.hokudai.ac.jp.
  slot:
    index: 8
    item: Iwasaki N
      type: Person
      first name: Norimasa
      last name: Iwasaki
      member of: Department of Orthopedic Surgery, Faculty of Medicine and Graduate of Medicine, Hokkaido University, N15W7, Sapporo, Hokkaido, 065-0024, Japan.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T21:53
e ISSN: 1436-2023
has issn l: 0949-2658
has NLM journal title abbreviation: J Orthop Sci
publication name: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
language: eng
has national library of medicine journal id: 9604934
derived from: NLM
has place of publication: Japan
source: J Orthop Sci. 2025-01-07;():.

Effect of human amniotic membrane on the consolidation during bone lengthening by distraction: Experimental study in rabbits.
pmid: 39765394
abstract: This study aimed to assess the effect of implantation of fresh human amniotic membranes (HAM) on bone consolidation during distraction bone lengthening.Ten New Zealand white rabbits were used in this study. For each rabbit, we performed a diaphyseal tibial osteotomy after installing a single-plane distraction external fixator. Rabbits were divided into 2 groups (n = 5): an osteotomy and rapid lengthening of 2.8 mm/days (negative control (NC) group) or an osteotomy with implantation of fresh HAM and rapid lengthening of 2.8 mm/days (HAM group). We carried out a rapid lengthening at a rate of 2 turns/day for 7 days and a single turn on the 8th day knowing that one turn corresponds to an elongation of 1.4 mm. The total elongation obtained was 21 mm corresponding to 20-25 % of the length of the rabbit's tibia. A radiological study was carried out on 4 and 8 weeks after the end of lengthening. Micro-computed tomography (μ-CT) analysis was carried out 8 weeks after the end of the lengthening and after the sacrifice of the rabbits associated with histological analyses.For the HAM group, radiographic analysis showed that all cases consolidated with a homogeneous callus visible at 1 month after lengthening, and complete corticalization was demonstrated at μ-CT analysis. Histological staining exhibited thick continuous cortices with intramedullary fibro adipose tissue with a medulla rich in hematopoietic cells.The results show that HAM affects the stimulation of bone consolidation during bone lengthening by distraction.
rights: Copyright © 2024 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
has PII: S0949-2658(24)00270-7
doi: 10.1016/j.jos.2024.11.011
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Elmounedi N
      type: Person
      first name: Najah
      last name: Elmounedi
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia. Electronic address: najah.mounedi12@gmail.com.
  slot:
    index: 2
    item: Sahnoun N
      type: Person
      first name: Nizar
      last name: Sahnoun
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia; Department of Orthopedics and Traumatology, CHU Habib Bourguiba, Sfax, Tunisia.
  slot:
    index: 3
    item: Guidara AR
      type: Person
      first name: Ahmed Racem
      last name: Guidara
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia; Department of Orthopedics and Traumatology, CHU Habib Bourguiba, Sfax, Tunisia.
  slot:
    index: 4
    item: Bahloul W
      type: Person
      first name: Walid
      last name: Bahloul
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia; Department of Orthopedics and Traumatology, CHU Habib Bourguiba, Sfax, Tunisia.
  slot:
    index: 5
    item: Keskes K
      type: Person
      first name: Khaled
      last name: Keskes
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia.
  slot:
    index: 6
    item: Ellouz Z
      type: Person
      first name: Zoubaier
      last name: Ellouz
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia; Department of Orthopedics and Traumatology, CHU Habib Bourguiba, Sfax, Tunisia.
  slot:
    index: 7
    item: Elbaya W
      type: Person
      first name: Walid
      last name: Elbaya
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia.
  slot:
    index: 8
    item: Keskes H
      type: Person
      first name: Hassib
      last name: Keskes
      member of: Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia; Department of Orthopedics and Traumatology, CHU Habib Bourguiba, Sfax, Tunisia.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:53
e ISSN: 1436-2023
has issn l: 0949-2658
has NLM journal title abbreviation: J Orthop Sci
publication name: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
language: eng
has national library of medicine journal id: 9604934
derived from: NLM
has place of publication: Japan
source: J Orthop Sci. 2025-01-06;():.

Targeting cholesterol-dependent adrenal steroidogenesis for management of primary aldosteronism.
pmid: 39765399
abstract: Primary aldosteronism (PA) is a common, salt-sensitive form of endocrine hypertension. Compared with essential hypertension (EH), PA is more susceptible to cardiorenal complications and metabolic risks. However, PA has a low screening rate and a poor response to mineralocorticoid receptor antagonists (MRAs). In addition to somatic ion channel mutations and epigenetic alterations, which contribute to excessive production of aldosterone, cholesterol, as a crucial precursor for aldosterone biosynthesis, may be involved in PA pathogenesis. Abnormal adrenal cholesterol uptake and steroidogenesis have been found in patients with PA. Therefore, we propose that a statin-based therapeutic strategy may be pivotal for antagonizing PA-related comorbidities by targeting cholesterol-dependent adrenal steroidogenesis.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1043-2760(24)00323-0
doi: 10.1016/j.tem.2024.12.001
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Wu H
      type: Person
      first name: Hao
      last name: Wu
      member of: Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, Chongqing Institute of Hypertension, Chongqing, China.
  slot:
    index: 2
    item: He H
      type: Person
      first name: Hongbo
      last name: He
      member of: Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, Chongqing Institute of Hypertension, Chongqing, China.
  slot:
    index: 3
    item: Han T
      type: Person
      first name: Tong
      last name: Han
      member of: Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, Chongqing Institute of Hypertension, Chongqing, China.
  slot:
    index: 4
    item: Tian X
      type: Person
      first name: Xiaoyu
      last name: Tian
      member of: School of Biomedical Sciences, Heart, and Vascular Institute, The Chinese University of Hong Kong, Hong Kong.
  slot:
    index: 5
    item: Zhu Z
      type: Person
      first name: Zhiming
      last name: Zhu
      member of: Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Army Medical University, Chongqing Institute of Hypertension, Chongqing, China; Chongqing Institute for Brain and Intelligence, Chongqing, China. Electronic address: zhuzm@tmmu.edu.cn.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:54
e ISSN: 1879-3061
has issn l: 1043-2760
has NLM journal title abbreviation: Trends Endocrinol Metab
publication name: Trends in endocrinology and metabolism: TEM
language: eng
has national library of medicine journal id: 9001516
derived from: NLM
has place of publication: United States
source: Trends Endocrinol Metab. 2025-01-06;():.

Microbial community analysis of supragingival plaque in patients with fixed prostheses.
pmid: 39765413
abstract: Harmony between prostheses and periodontal tissues is essential. The presence of a fixed prosthesis has been reported to increase the risk of periodontal lesion onset in abutment teeth and to affect longevity. However, studies comparing the supragingival plaque biofilm on fixed prostheses and natural teeth are lacking.The purpose of this clinical study was to investigate the composition of supragingival plaque biofilm microorganisms on the surface of fixed prostheses and to identify differences with those of natural supragingival plaque microorganisms using 16S ribosomal deoxyribonucleic acid (rDNA) sequencing technology.A total of 40 participants were enrolled, including 20 with fixed prostheses and 20 healthy participants with no prostheses in the mouth; 60 samples of supragingival plaque were obtained. The groups included in this analysis were the cobalt chromium metal-ceramic crown group (P), zirconia ceramic crown group (A), natural tooth group with zirconia ceramic crown control (T_A), natural tooth group with cobalt chromium metal-ceramic crown control (T_P), and healthy group with no prostheses in the mouth (SUPP_A). The DNA of all samples was sequenced by using the 16S rDNA high-throughput sequencing technology, and the sequencing data were then examined bioinformatically using the Qiime, R, and PICRUSt2 software programs.The microbial composition and structural diversity of supragingival plaque on the surface of fixed prostheses were found to differ from those on natural teeth, with relatively high levels of periodontally related pathogens, including Treponema gingivalis, Selenomonas gingivalis, Porphyromonas gingivalis, and Prevotella_7 gingivalis. Functional analysis revealed that the fixed prosthesis group had relatively active microbial communities. The metabolism was relatively active, characterized by a high percentage of lipopolysaccharide biosynthesis, glycine, serine, and threonine metabolism associated with the development of periodontal disease.[cell cut: 2650 characters, first 2000 kept]
rights: Copyright © 2025 Editorial Council for The Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.
has PII: S0022-3913(24)00832-1
doi: 10.1016/j.prosdent.2024.12.015
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Cui L
      type: Person
      first name: Lingjun
      last name: Cui
      member of: Graduate student, Department of Stomatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Xiangzhou, Zhuhai City, Guangdong, PR China.
  slot:
    index: 2
    item: Bao X
      type: Person
      first name: Xin
      last name: Bao
      member of: Resident, Department of Stomatology, Tai'an Central Hospital, 29 Longtan Road, Tai'an, Shandong Province, PR China.
  slot:
    index: 3
    item: Yan Y
      type: Person
      first name: Yueyang
      last name: Yan
      member of: Doctoral student, Key Laboratory for Zoonoses Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, PR China.
  slot:
    index: 4
    item: Zhai J
      type: Person
      first name: Jingjie
      last name: Zhai
      member of: Attending, Hospital of Stomatology, Jilin University, Changchun, PR China.
  slot:
    index: 5
    item: Li X
      type: Person
      first name: Xiangwei
      last name: Li
      member of: Professor, Department of Stomatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Xiangzhou, Zhuhai City, Guangdong, PR China.
  slot:
    index: 6
    item: Li Q
      type: Person
      first name: Qiushi
      last name: Li
      member of: Associate Professor, Department of Stomatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Xiangzhou, Zhuhai City, Guangdong, PR China. Electronic address: liqsh26@mail.sysu.edu.cn.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:54
e ISSN: 1097-6841
has issn l: 0022-3913
has NLM journal title abbreviation: J Prosthet Dent
publication name: The Journal of prosthetic dentistry
language: eng
has national library of medicine journal id: 0376364
derived from: NLM
has place of publication: United States
source: J Prosthet Dent. 2025-01-06;():.

Response to Comments on Fibrosis-4 index stratifies risks of hepatocellular carcinoma in patients with chronic hepatitis C″.
pmid: 39765421
has PII: S0929-6646(24)00616-8
doi: 10.1016/j.jfma.2024.12.037
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Su TH
      type: Person
      first name: Tung-Hung
      last name: Su
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.
  slot:
    index: 2
    item: Kao JH
      type: Person
      first name: Jia-Horng
      last name: Kao
      member of: Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: kaojh@ntu.edu.tw.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T21:55
ISSN: 0929-6646
has issn l: 0929-6646
has NLM journal title abbreviation: J Formos Med Assoc
publication name: Journal of the Formosan Medical Association = Taiwan yi zhi
language: eng
has national library of medicine journal id: 9214933
derived from: NLM
has place of publication: Singapore
source: J Formos Med Assoc. 2025-01-07;():.

Single-session ethanol ablation in the treatment of thyroid cysts ≥10 mL: Effectiveness and influencing factors.
pmid: 39765422
abstract: Ethanol ablation (EA) has been proposed as a first-line treatment modality for recurrent symptomatic cystic thyroid nodules following initial aspiration. The efficacy of EA can be compromised when the initial nodule volume exceeds 10 mL. This study assessed the efficacy of single-session EA in managing thyroid cysts with an initial volume of ≥10 mL.This retrospective study included 70 patients, stratified into three groups on the basis of initial nodule volume: Group 1 (≥10, <20 mL), Group 2 (≥20, <40 mL), and Group 3 (≥40 mL). Primary outcomes were the volume reduction ratio (VRR) and therapeutic success rate (VRR >50%) at the 6-month follow-up post-EA. Secondary outcomes included improvements in symptom scores, cosmetic grades, and identification of factors influencing VRR.The median VRR at the 6-month was 94.8% (interquartile ranges: 88.3-98.1%), with a therapeutic success rate of 90%. Significant improvements were observed in nodule volume, symptom scores, and cosmetic grades (all p < 0.001). Nodules ≥40 mL had poorer symptom scores and cosmetic grades compared to nodules with volumes of ≥10 mL and <20 mL (p < 0.05), though VRR differences were not significant (p = 0.944). Solid portions and nodule vascularity negatively impacted VRR (p = 0.001 and p = 0.002).Single-session EA effectively reduces volume and improves symptoms and cosmetic outcomes for cystic thyroid nodules ≥10 mL, though larger, solid, and vascular nodules may require tailored treatment strategies.
rights: Copyright © 2025 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.
has PII: S0929-6646(24)00619-3
doi: 10.1016/j.jfma.2024.12.040
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Cheng KL
      type: Person
      first name: Kai-Lun
      last name: Cheng
      member of: Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  slot:
    index: 2
    item: Lai PH
      type: Person
      first name: Pin-Hsien
      last name: Lai
      member of: Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  slot:
    index: 3
    item: Su CL
      type: Person
      first name: Chun-Lang
      last name: Su
      member of: Chung Jen Junior College of Nursing, Health Science Management, Yunlin, Taiwan; Department of Rehabilitation, Tung Wah Hospital, Nantou, Taiwan.
  slot:
    index: 4
    item: Lee YS
      type: Person
      first name: Yu-Shen
      last name: Lee
      member of: Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  slot:
    index: 5
    item: Lee HL
      type: Person
      first name: Hsiang-Lin
      last name: Lee
      member of: School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: s31079@gmail.com.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-7T21:55
ISSN: 0929-6646
has issn l: 0929-6646
has NLM journal title abbreviation: J Formos Med Assoc
publication name: Journal of the Formosan Medical Association = Taiwan yi zhi
language: eng
has national library of medicine journal id: 9214933
derived from: NLM
has place of publication: Singapore
source: J Formos Med Assoc. 2025-01-07;():.

Comment on Fibrosis-4 index stratifies risks of hepatocellular carcinoma in patients with chronic hepatitis C″: Fibrosis-4 index and hepatocellular carcinoma.
pmid: 39765424
has PII: S0929-6646(24)00613-2
doi: 10.1016/j.jfma.2024.12.034
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wang Z
      type: Person
      first name: Ziyi
      last name: Wang
      member of: Shanxi Bethune Hospital, Shanxi, China. Electronic address: 13100151533@163.com.
  slot:
    index: 2
    item: Wang Z
      type: Person
      first name: Zihan
      last name: Wang
      member of: First Hospital of Shanxi Medical University, Shanxi, China.
  slot:
    index: 3
    item: Niu Y
      type: Person
      first name: Yumin
      last name: Niu
      member of: Shanxi Bethune Hospital, Shanxi, China.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:55
ISSN: 0929-6646
has issn l: 0929-6646
has NLM journal title abbreviation: J Formos Med Assoc
publication name: Journal of the Formosan Medical Association = Taiwan yi zhi
language: eng
has national library of medicine journal id: 9214933
derived from: NLM
has place of publication: Singapore
source: J Formos Med Assoc. 2025-01-06;():.

http://rdf.ncbi.nlm.nih.gov/pubmed/39765425
pmid: 39765425
abstract: The effect of conservative treatments on sleep quality in carpal tunnel syndrome is unclear.Comparing the effect of splinting and kinesiotaping in carpal tunnel syndrome on functional status, pain, grip strength, nerve cross-sectional area and sleep quality.Randomized controlled study.The participants were divided into three groups. One group was given night splint and nerve tendon gliding exercises, one group was given kinesiotaping and nerve tendon gliding exercises and one group was given only nerve tendon gliding exercises. The participants was evaluated with Visual Analog Scale (VAS), Boston Carpal Tunnel Syndrome Questionnaire, Pittsburgh Sleep Quality Index (PSQI), Jamar hand dynamometer, ultrasonography by a blind investigator in the treatment group at baseline and at 3 months.A total of 90 participants, 53 women and 37 men, with a mean age of 47.6±10.5, participated in the study. The decrease in Boston symptom severity and functional status scores was higher in the kinesiotaping group than in the splint group (Cohen's d=-0.78). A statistically significant decrease was found in PSQI scores in all groups (p<0.05). A statistically significant decrease was found in the PSQI total and sleep duration component score in the kinesiotaping group compared to the splint group and the exercise group (Cohen's d=0.69).Both splinting and kinesiotaping are effective on pain, functional status, hand grip strength and median nerve cross-sectional area. This effect is greater in kinesiotaping. Splinting, kinesiotaping and nerve tendon gliding exercises treatments are effective in improving sleep quality, but this effect is greater in kinesiotaping.gov ID: NCT06514625.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0894-1130(24)00168-6
doi: 10.1016/j.jht.2024.12.001
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Karpuz S
      type: Person
      first name: Savaş
      last name: Karpuz
      member of: Konya Beyhekim Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Konya, Turkey. Electronic address: svskrpz@hotmail.com.
  slot:
    index: 2
    item: Yilmaz R
      type: Person
      first name: Ramazan
      last name: Yilmaz
      member of: Konya Beyhekim Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Konya, Turkey.
  slot:
    index: 3
    item: Özkan M
      type: Person
      first name: Mehmet
      last name: Özkan
      member of: Konya Beyhekim Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Konya, Turkey.
  slot:
    index: 4
    item: Kaya İÇ
      type: Person
      first name: İlhan Çağlar
      last name: Kaya
      member of: Konya Beyhekim Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Konya, Turkey.
  slot:
    index: 5
    item: Bulut O
      type: Person
      first name: Onur
      last name: Bulut
      member of: Konya City Hospital, Clinical Neurophysiology, Konya, Turkey.
  slot:
    index: 6
    item: Erol K
      type: Person
      first name: Kemal
      last name: Erol
      member of: Selcuk University Faculty of Medicine, Rheumatology, Konya, Turkey.
  slot:
    index: 7
    item: Yilmaz H
      type: Person
      first name: Halim
      last name: Yilmaz
      member of: Konya Beyhekim Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Konya, Turkey.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:55
e ISSN: 1545-004X
has issn l: 0894-1130
has NLM journal title abbreviation: J Hand Ther
publication name: Journal of hand therapy : official journal of the American Society of Hand Therapists
language: eng
has national library of medicine journal id: 8806591
derived from: NLM
has place of publication: United States
source: J Hand Ther. 2025-01-06;():.
title: Effect of splinting and kinesiotaping treatments on functional status, sleep quality and median nerve cross-sectional area in carpal tunnel syndrome: A single blind prospective randomized controlled study.

Quantifying thenar muscle biomechanical properties: Sex-based variations and implications for grip strength.
pmid: 39765426
abstract: Quantifying the biomechanical properties of the thenar muscle can provide valuable insight into hand assessment methods.This study aimed to examine the reliability of myotonometer measurements in determining the biomechanical properties (tone, stiffness and elasticity) of thenar muscles in healthy individuals and explore sex-based variations. Additionally, it assessed the relationship between pinch strength and these properties.Cross-sectional reliability study.Fifty-five healthy young adult participants were recruited. Biomechanical properties of the abductor pollicis brevis and flexor pollicis brevis muscles - tone (Hz), stiffness (N/m), and elasticity (logarithmic decrement)-were measured using MyotonPRO, while pinch strength was assessed using a Baseline pinch gauge bilaterally. For intrarater reliability, the first rater (R1), conducted two sets of measurements at 30-minute intervals. Inter-rater reliability was evaluated by the second rater (R2) performing a set of measurements between R1's two sets.Fifty participants [mean age=22.84 (1.01) years, mean body mass index=20.86 (2.82) kg/m²] completed the study. Test-retest reliability for the biomechanical properties of the abductor pollicis brevis and flexor pollicis brevis muscles showed good to excellent consistency (ICCs: 0.78-0.97). Inter-rater reliability demonstrated sufficient consistency across (ICCs: 0.78-0.93). Sex-based differences were observed on the nondominant side, with males exhibiting lower logarithmic decrement scores for both muscles (p<0.05). Negative correlations were found between pinch strength and abductor pollicis brevis logarithmic decrement scores on both sides (p<0.05).The study confirms the reliability of MyotonPRO in evaluating the mechanical properties of the thenar muscle in healthy subjects, with good to excellent consistency. Sex-based differences in elasticity, along with the positive correlation between pinch strength, underscore the importance of sex-specific considerations,[cell cut: 2113 characters, first 2000 kept]
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0894-1130(24)00165-0
doi: 10.1016/j.jht.2024.11.009
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Saldıran TÇ
      type: Person
      first name: Tülay Çevik
      last name: Saldıran
      member of: Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey. Electronic address: tlyfztcvk@gmail.com.
  slot:
    index: 2
    item: Schleip R
      type: Person
      first name: Robert
      last name: Schleip
      member of: Conservative and Rehabilitative Orthopedics, Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany; Experimental Anaesthesiology, Ulm University, Ulm, Germany.
  slot:
    index: 3
    item: Tanhan A
      type: Person
      first name: Abdurrahman
      last name: Tanhan
      member of: Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey.
  slot:
    index: 4
    item: Öztürk Ö
      type: Person
      first name: Özgül
      last name: Öztürk
      member of: Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Acıbadem Mehmet Ali Aydınlar University, İstanbul, Turkey.
  slot:
    index: 5
    item: Kara İ
      type: Person
      first name: İlke
      last name: Kara
      member of: Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Bitlis Eren University, Bitlis, Turkey; Department of Physical Therapy and Rehabilitation, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:55
e ISSN: 1545-004X
has issn l: 0894-1130
has NLM journal title abbreviation: J Hand Ther
publication name: Journal of hand therapy : official journal of the American Society of Hand Therapists
language: eng
has national library of medicine journal id: 8806591
derived from: NLM
has place of publication: United States
source: J Hand Ther. 2025-01-06;():.

Is Kinesio taping an alternative to static wrist orthosis in patients with carpal tunnel syndrome? A randomized clinical trial.
pmid: 39765428
abstract: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity. Conservative treatments are effective for treating mild and moderate CTS. There is still a need for studies to investigate the superiority of conservative treatments over each other.The aim of our study was to compare the efficacy of orthosis treatment and Kinesio taping (KT) treatment on pain, functional status, and grip strength in patients with idiopathic CTS.Randomized clinical trial.Sixty patients (90% women) who were diagnosed with mild or moderate CTS by electroneuromyography were included in this study. Patients were randomized into two groups: the orthosis and KT groups. Hand grip, and three-point pinch strength measuring with a dynamometer and a pinch meter, Visual Analog Scale (VAS), Boston Carpal Tunnel Syndrome Questionnaire (BCTQ), Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale (LANSS), and Short Form-36 Health Survey Questionnaire (SF-36) were used in clinical assessment. Clinical evaluations were made baseline and at the end of 4 weeks of treatment.Both KT and static wrist orthosis were found to be effective on SF-36 pain, VAS rest, VAS activity, LANSS, grip strength, three-point pinch strength, BCTQ symptom, and functional scores. The changes in VAS activity (between-group mean difference [MD] = -0.93; CI = -1.83:-0.03; p < 0.05; d = 1.74), BCTQ function scores (MD = -2.60; CI = -5.39:0.19; p < 0.05, d = 5.40), and SF-36 mental health scores (MD = 5.87; CI = 1.15:10.59; p < 0.05; d = 9.13) were significantly higher in the KT group compared to the orthosis group.KT, which is a straightforward and safe treatment that does not restrict daily activities, may offer a beneficial alternative to restrictive and uncomfortable orthosis therapy for treating mild to moderate CTS in those leading active daily lives.
rights: Copyright © 2025 Elsevier Inc. All rights reserved.
has PII: S0894-1130(24)00063-2
doi: 10.1016/j.jht.2024.08.002
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: İnceboy D
      type: Person
      first name: Didem
      last name: İnceboy
      member of: Istanbul Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Istanbul, Turkey.
  slot:
    index: 2
    item: Aytekin E
      type: Person
      first name: Ebru
      last name: Aytekin
      member of: Istanbul Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Istanbul, Turkey.
  slot:
    index: 3
    item: Oğuz M
      type: Person
      first name: Muhammed
      last name: Oğuz
      member of: Istanbul Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Istanbul, Turkey. Electronic address: droguzmuhammed@gmail.com.
  slot:
    index: 4
    item: Dede BT
      type: Person
      first name: Burak Tayyip
      last name: Dede
      member of: Cemil Tascioglu City Hospital, Physical Medicine and Rehabilitation Clinic, İstanbul, Turkey.
  slot:
    index: 5
    item: Bulut GT
      type: Person
      first name: Gül Tuğba
      last name: Bulut
      member of: Istanbul Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Istanbul, Turkey.
  slot:
    index: 6
    item: Pekin Doğan Y
      type: Person
      first name: Yasemin
      last name: Pekin Doğan
      member of: Istanbul Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Istanbul, Turkey.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:55
e ISSN: 1545-004X
has issn l: 0894-1130
has NLM journal title abbreviation: J Hand Ther
publication name: Journal of hand therapy : official journal of the American Society of Hand Therapists
language: eng
has national library of medicine journal id: 8806591
derived from: NLM
has place of publication: United States
source: J Hand Ther. 2025-01-06;():.

Kinesiophobia, catastrophizing, and the duration of immobilization: A prospective study on factors associated with shoulder disability following wrist-hand injuries.
pmid: 39765429
abstract: Shoulder pain is a major musculoskeletal problem after wrist-hand immobilization. There is limited evidence regarding the relationship of kinesiophobia or pain catastrophizing with shoulder pain and disability after wrist-hand injury.To explore associations between kinesiophobia and pain catastrophizing with ipsilateral persistent shoulder disability in patients with wrist-hand injury after 6 months.Prospective study.Participants aged ≥18 years referred to hand therapy after wrist-hand injury requiring wrist-hand immobilization were recruited and completed the Numeric Pain Scale, Shoulder Pain and Disability Index, Pain Catastrophizing Scale (PCS), and Tampa scale for kinesiophobia (TSK) at baseline, after an immobilization period, and after 6 months.A total of 107 patients were included in the study. Scaphoid fractures were found in 49 (45.8%) of patients, and 58 (54.2%) had distal radius fractures. For each week of increased time spent in immobilization, the Shoulder Pain and Disability Index score increased by 10.2 points, 95% confidence interval (CI) [6.76, 13.57], with higher levels of immobilization being associated with increased shoulder pain and disability. The baseline TSK score was 17.4 and 11.2 at follow-up. The PCS score was initially 14.8 and decreased to 9.3 at follow-up. The addition of TSK and PCS to the predictive model led to a statistically significant increase in R2 of 0.163, F(2,100) = 47.471, p < 0.001.The duration of wrist immobilization following an injury may play a crucial role in the level of shoulder disability experienced at the 6-month mark post-injury. This shoulder disability may be influenced by factors such as fear of movement.
rights: Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S0894-1130(24)00061-9
doi: 10.1016/j.jht.2024.08.004
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Cantero-Téllez R
      type: Person
      first name: Raquel
      last name: Cantero-Téllez
      member of: Physiotherapy Department, Faculty of Health Sciences, University of Malaga, Málaga, Spain; IBIMA Hand Research Group FE-17, Málaga, Spain.
  slot:
    index: 2
    item: Rider J
      type: Person
      first name: John
      last name: Rider
      member of: School of Occupational Therapy, Touro University, Henderson, NV 33204, USA.
  slot:
    index: 3
    item: Cruz-Gambero L
      type: Person
      first name: Leire
      last name: Cruz-Gambero
      member of: Physiotherapy Department, Faculty of Health Sciences, University of Malaga, Málaga, Spain; IBIMA Hand Research Group FE-17, Málaga, Spain. Electronic address: leiregam@uma.es.
  slot:
    index: 4
    item: Villafañe JH
      type: Person
      first name: Jorge H
      last name: Villafañe
      member of: Universidad Europea de Madrid, Villaviciosa de Odón, Spain.
  slot:
    index: 5
    item: Valdes K
      type: Person
      first name: Kristin
      last name: Valdes
      member of: School of Occupational Therapy, Touro University, Henderson, NV 33204, USA.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:55
e ISSN: 1545-004X
has issn l: 0894-1130
has NLM journal title abbreviation: J Hand Ther
publication name: Journal of hand therapy : official journal of the American Society of Hand Therapists
language: eng
has national library of medicine journal id: 8806591
derived from: NLM
has place of publication: United States
source: J Hand Ther. 2025-01-06;():.

Evaluation of mid vs distal left anterior descending artery measures in coronary physiology assessment.
pmid: 39765437
abstract: Angina with no obstructive coronary artery disease (ANOCA) occurs in approximately 40 % of patients who undergo diagnostic coronary angiography for symptoms of angina. Coronary physiology assessment (CPA) is a guideline proven method to assess and diagnose these patients for an effective treatment strategy. There is currently no data regarding optimal wire or sensor position for CPA using bolus coronary thermodilution.We reviewed CPA data and baseline demographics in a cohort of patients who underwent CPA for ANOCA. We evaluated coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) in patients whereby maximal hyperemia was obtained in the middle portion (4-6 cm) of the left anterior descending artery (LAD) and the distal 2/3 of the LAD using linear regression, Paired t-test, and Bland-Altman analysis.We assessed 42 patients with a median age of 60.5 [50,67] and 72 % female. Median CFR in the mid-LAD was 3.55 [2.54, 4.58] and 2.71 [2.0,3.88; p = 0.01*] in the distal segment. Median IMR in the mid-LAD was 16.41 mmHg*s [10.60, 22.07] and 22.27 mmHg*s [14.79,37.0] in the distal segment (p = 0.01*). Average distal pressures (Pd) were 77.14 mmHg in the mid and 75.31 mmHg in the distal LAD (p = 0.57) with differing resting (0.75 s vs 0.97 s, p = 0.01*) and hyperemic (0.25 vs 0.40, p = 0.003*) transit times in the mid vs distal vessel, respectively.Here we demonstrate that CPA outcomes including CFR and IMR values are dependent upon wire positioning with deeper wire position resulting in lower CFR and higher IMR values.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S1553-8389(24)00758-9
doi: 10.1016/j.carrev.2024.12.018
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Dalal F
      type: Person
      first name: Fazal
      last name: Dalal
      member of: Department of Internal Medicine, Baylor Scott and White, Temple, TX, United States of America.
  slot:
    index: 2
    item: Escobedo Y
      type: Person
      first name: Yissela
      last name: Escobedo
      member of: Department of Internal Medicine and Division of Cardiology, Baylor Scott and White, Temple, TX, United States of America.
  slot:
    index: 3
    item: Exaire JE
      type: Person
      first name: Jose Emilio
      last name: Exaire
      member of: Department of Internal Medicine and Division of Cardiology, Baylor Scott and White, Temple, TX, United States of America.
  slot:
    index: 4
    item: Mixon TA
      type: Person
      first name: Timothy A
      last name: Mixon
      member of: Department of Internal Medicine and Division of Cardiology, Baylor Scott and White, Temple, TX, United States of America.
  slot:
    index: 5
    item: Al-Azizi K
      type: Person
      first name: Karim
      last name: Al-Azizi
      member of: Baylor Baylor Scott and White, The Heart Hospital, Department of Cardiology, Plano, TX, United States of America.
  slot:
    index: 6
    item: Kumar D
      type: Person
      first name: Darren
      last name: Kumar
      member of: Baylor Heart and Vascular Hospital, Department of Cardiology, Baylor Scott and White, Fort Worth, TX, United States of America.
  slot:
    index: 7
    item: Potluri S
      type: Person
      first name: Srini
      last name: Potluri
      member of: Baylor Baylor Scott and White, The Heart Hospital, Department of Cardiology, Plano, TX, United States of America.
  slot:
    index: 8
    item: Widmer RJ
      type: Person
      first name: R Jay
      last name: Widmer
      member of: Department of Internal Medicine and Division of Cardiology, Baylor Scott and White, Temple, TX, United States of America. Electronic address: Robert.Widmer@bswhealth.org.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2024-12-28
dp: 2024 Dec 28
created: 2025-1-7T21:55
e ISSN: 1878-0938
has issn l: 1878-0938
has NLM journal title abbreviation: Cardiovasc Revasc Med
publication name: Cardiovascular revascularization medicine : including molecular interventions
language: eng
has national library of medicine journal id: 101238551
derived from: NLM
has place of publication: United States
source: Cardiovasc Revasc Med. 2024-12-28;():.

Sex-based differences in cardiovascular outcomes among patients with atrial fibrillation undergoing left atrial appendage occlusion device placement.
pmid: 39765440
abstract: There is a growing body of data to support the presence of sex disparities in outcomes of cardiovascular related hospitalizations. Despite this, there remains a paucity of data on relationships between sex and in-hospital outcomes in patients receiving a left atrial appendage occlusion device (LAAOD).We examined the 2016-2020 Nationwide Readmission Database to identify patients with Atrial Fibrillation receiving a LAAOD. Men compromised the control group, while women comprised the cohort. The primary outcome was mortality. Secondary outcomes included odds of mechanical ventilation use, all cause 30 and 90 day readmission, pericardial complications, vascular complications requiring surgery and length of stay (LOS). Multivariate regression models were used to adjust for confounders.Among the patients with Atrial fibrillation receiving LAAOD (N = 59,655), 43 % were Female. A Female sex was associated with higher odds of mortality (adjusted OR [aOR] 1.92, 95 % CI 1.04-3.5), mechanical ventilation use (aOR 2.02, 95 % CI 1.4-2.9), all cause 30-day readmission (aOR 1.33, 95 % CI 1.22-1.45), all cause 90-day readmissions (aOR 1.31, 95 % CI 1.2-1.43), pericardial complications (aOR 2.5, 95 % CI 1.83-3.3), and longer LOS (1.34 vs 1.19 days, p < 0.001) compared to male patients. No differences were observed regarding vascular complications requiring surgery between both groups.The LAAOD procedure is a highly safe and effective intervention for patients with atrial fibrillation. However, a small subset of patients experiences fatal and non-fatal adverse outcomes, with women disproportionately affected. Further studies are needed to confirm these findings.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S1553-8389(24)00763-2
doi: 10.1016/j.carrev.2024.12.016
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Abdallah N
      type: Person
      first name: Nadhem
      last name: Abdallah
      member of: Department of Internal Medicine, Hennepin Healthcare, Minneapolis, MN, USA. Electronic address: nadhem.abdallah@hcmed.org.
  slot:
    index: 2
    item: Mohamoud A
      type: Person
      first name: Abdilahi
      last name: Mohamoud
      member of: Department of Internal Medicine, Hennepin Healthcare, Minneapolis, MN, USA.
  slot:
    index: 3
    item: Almasri T
      type: Person
      first name: Talal
      last name: Almasri
      member of: Department of Internal Medicine, Hennepin Healthcare, Minneapolis, MN, USA.
  slot:
    index: 4
    item: Abdallah M
      type: Person
      first name: Meriam
      last name: Abdallah
      member of: University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  slot:
    index: 5
    item: Karim R
      type: Person
      first name: Rehan
      last name: Karim
      member of: Cardiology Division, Hennepin Healthcare, Minneapolis, MN, USA.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2024-12-28
dp: 2024 Dec 28
created: 2025-1-7T21:55
e ISSN: 1878-0938
has issn l: 1878-0938
has NLM journal title abbreviation: Cardiovasc Revasc Med
publication name: Cardiovascular revascularization medicine : including molecular interventions
language: eng
has national library of medicine journal id: 101238551
derived from: NLM
has place of publication: United States
source: Cardiovasc Revasc Med. 2024-12-28;():.

Impact of pulmonary hypertension on short and long-term outcome after mitral transcatheter edge-to-edge repair: A meta-analysis.
pmid: 39765439
abstract: Pulmonary hypertension (pHTN) has been associated with increased morbidity and mortality after mitral Transcatheter Edge-to-Edge Repair (TEER), but the association remains uncertain. This study aims to evaluate the impact of pHTN on cardiovascular outcomes following TEER.We searched PubMed, Scopus, and Medline to identify studies reporting outcomes after TEER in individuals with pHTN. Utilizing a random-effects model, we ascertained a pooled odds ratio (OR) of clinical outcomes in patients with pulmonary artery systolic pressure (PASP >50 mmHg) vs. without (PASP <50 mmHg) severe pHTN.We included seven studies with 27,965 patients. The mean age was 79.9 (±5.2) years; 53 % were male, and 75 % were New York Heart Association (NYHA) class-III/IV with a median follow-up of 360 days. Patients with severe pHTN had higher odds of in-hospital all-cause mortality (OR: 1.99, 95 % CI: 1.69-2.34, p < 0.00001) and Major adverse cardiovascular events (MACE) (OR: 1.38, 95 % CI: 1.22-1.56, p < 0.00001) compared to patients without severe pHTN.Severe pHTN is associated with increased risks of all-cause mortality, MACE, and higher heart failure rehospitalizations in patients undergoing mitral TEER. Prospective trials are necessary to validate the findings and determine if early intervention improves clinical outcomes.
rights: Copyright © 2025 Elsevier Inc. All rights reserved.
has PII: S1553-8389(24)00757-7
doi: 10.1016/j.carrev.2024.12.012
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Neppala S
      type: Person
      first name: Sivaram
      last name: Neppala
      member of: Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA.
  slot:
    index: 2
    item: Chigurupati HD
      type: Person
      first name: Himaja Dutt
      last name: Chigurupati
      member of: Department of Medicine, New York Medical College at Saint Michael's Medical Center, Newark, NJ, USA.
  slot:
    index: 3
    item: Fath A
      type: Person
      first name: Ayman
      last name: Fath
      member of: Division of Cardiology, Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA.
  slot:
    index: 4
    item: Jagirdhar GSK
      type: Person
      first name: Gowthami Sai Kogilathota
      last name: Jagirdhar
      member of: Department of Medicine, New York Medical College at Saint Michael's Medical Center, Newark, NJ, USA.
  slot:
    index: 5
    item: Sandhyavenu H
      type: Person
      first name: Harigopal
      last name: Sandhyavenu
      member of: Division of Cardiology, Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA.
  slot:
    index: 6
    item: Bolte J
      type: Person
      first name: Jeffery
      last name: Bolte
      member of: Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA.
  slot:
    index: 7
    item: Muhammad AN
      type: Person
      first name: Abdullah Naveed
      last name: Muhammad
      member of: Dow University of Health Sciences, Karachi, Pakistan.
  slot:
    index: 8
    item: Sattar Y
      type: Person
      first name: Yasar
      last name: Sattar
      member of: Department of Internal medicine and Cardiovascular disease, West Virginia University, Morgantown, WV, USA.
  slot:
    index: 9
    item: Desai R
      type: Person
      first name: Rupak
      last name: Desai
      member of: Independent Outcomes Researcher, Atlanta, GA, USA.
  slot:
    index: 10
    item: Defronzo RA
      type: Person
      first name: Ralph A
      last name: Defronzo
      member of: Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA.
  slot:
    index: 11
    item: Paul TK
      type: Person
      first name: Timir K
      last name: Paul
      member of: Department of Cardiovascular Sciences, Ascension St. Thomas Hospital/University of Tennessee Health Sciences Center, Nashville, TN, USA.
  slot:
    index: 12
    item: Prasad A
      type: Person
      first name: Anand
      last name: Prasad
      member of: Division of Cardiology, Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-02
dp: 2025 Jan 02
created: 2025-1-7T21:55
e ISSN: 1878-0938
has issn l: 1878-0938
has NLM journal title abbreviation: Cardiovasc Revasc Med
publication name: Cardiovascular revascularization medicine : including molecular interventions
language: eng
has national library of medicine journal id: 101238551
derived from: NLM
has place of publication: United States
source: Cardiovasc Revasc Med. 2025-01-02;():.

Reintervention after aortic root replacement with allograft, xenograft, and stented bioprosthetic valves.
pmid: 39765441
abstract: There has been a significant increase in the utilization of non-mechanical valves in the aortic position over time. However, details in reinterventions after aortic root replacement (ARR) with non-mechanical prosthesis were limited in the literature, despite the potential importance of reinterventions in the lifetime management of aortic valve disease.This is a single-center retrospective study, identifying all patients who underwent ARR with allograft, xenografts, and stented bioprosthetic valved conduit from 2010 to 2020. Cumulative incidence was plotted for aortic valve reintervention.A total of 523 patients underwent ARR with non-mechanical valves: allograft (n = 80, 15.3 %), xenograft (n = 267, 51.1 %), and stented bioprosthetic valved conduit (n = 176, 33.7 %). The mean age was 65.9 years old. A history of infective endocarditis was seen in 124 (23.7 %). Overall, valve reintervention was observed in 21 (4.0 %). The median time to reintervention was 4.77 years. The reason for valve reintervention included structural valve deterioration (n = 12), followed by infective endocarditis (n = 6), complication during mitral valve replacement (n = 1), cardiac mass (n = 1), and pseudoaneurysm (n = 1). None of the reinterventions were transcatheter-based. Expected reintervention rates were 8.1 ± 2.0 % at 10 years. Cox hazard regression analysis revealed ejection fraction <30 and heart failure were independently associated with long-term mortality while type of valve was not.Aortic valve reintervention was infrequent. Although subsequent valve in valve transcatheter intervention is often discussed when implanting non-mechanical valves, it was not a common strategy after ARR in our experience. The type of valve was not related to long-term mortality.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S1553-8389(24)00764-4
doi: 10.1016/j.carrev.2024.12.020
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Ogami T
      type: Person
      first name: Takuya
      last name: Ogami
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 2
    item: Serna-Gallegos D
      type: Person
      first name: Derek
      last name: Serna-Gallegos
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 3
    item: Thoma FW
      type: Person
      first name: Floyd W
      last name: Thoma
      member of: Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 4
    item: Chu D
      type: Person
      first name: Danny
      last name: Chu
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 5
    item: Bonatti JO
      type: Person
      first name: Johannes O
      last name: Bonatti
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 6
    item: Yoon PD
      type: Person
      first name: Pyongsoo D
      last name: Yoon
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 7
    item: Kaczorowski DJ
      type: Person
      first name: David J
      last name: Kaczorowski
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
  slot:
    index: 8
    item: Sultan I
      type: Person
      first name: Ibrahim
      last name: Sultan
      member of: Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America. Electronic address: sultani@upmc.edu.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2024-12-28
dp: 2024 Dec 28
created: 2025-1-7T21:55
e ISSN: 1878-0938
has issn l: 1878-0938
has NLM journal title abbreviation: Cardiovasc Revasc Med
publication name: Cardiovascular revascularization medicine : including molecular interventions
language: eng
has national library of medicine journal id: 101238551
derived from: NLM
has place of publication: United States
source: Cardiovasc Revasc Med. 2024-12-28;():.

Gender-Affirming Voice Therapy Duration and Satisfaction: Experiences from a Single Institution.
pmid: 39765446
abstract: Current literature involving gender-affirming voice therapy (GAVT) for transgender and nonbinary (TGNB) individuals is limited. This study describes treatment duration and satisfaction at a single institution.Retrospective cohort.Tertiary laryngology center.TGNB patients receiving gender-affirming treatment were identified.age, sex assigned at birth, gender identity, race, ethnicity, number/frequency of GAVT, Voice Handicap Index-10 (VHI-10), Trans Women Voice Questionnaire (TWVQ) (as appropriate), Gender Congruence Scale (GCS), patient and speech language pathologist (SLP) assessment of treatment satisfaction, and surgical data. Descriptive statistics were reported.82 TGNB patients [trans female (n=65), trans male (n=5), nonbinary (n=12)] sought gender-affirming voice care. Mean age was 33.6±10.7years. Majority were assigned male at birth (n=71). Mean presentation VHI-10 was 15.7±8. In the first year of treatment, patients had mean 5.7±3.1 (range 1-16, median 5) GAVT sessions, biweekly (n=36, 44%) or monthly (n=12, 15%). 62% (n=51) of patients were satisfied/very satisfied, 23% (n=19) fairly satisfied, and 10% (n=8) unsatisfied with GAVT outcomes. SLP impression of GAVT outcome was more variable: 15% (n=12) completely met voice goals and 11% (n=9) had excellent GAVT response. Most patients (39%, n=32) were making good progress, with further treatment recommended. SLP referred 11% (n=9) to the laryngologist for surgery consideration; 9% (n=6) underwent Wendler glottoplasty.Voice therapy is integral to gender-affirming voice care and often requires more sessions (mean 5.7) than the literature-reported average (∼4) for other voice diagnoses. Appropriate expectations should be set for patients, treating clinicians, and third-party payors about the increased anticipated duration of GAVT.
rights: Copyright © 2024 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
has PII: S0892-1997(24)00467-3
doi: 10.1016/j.jvoice.2024.12.032
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Laohakittikul C
      type: Person
      first name: Chanticha
      last name: Laohakittikul
      member of: UCSF Voice and Swallowing Center, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California; Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 2
    item: Gochman GE
      type: Person
      first name: Grant E
      last name: Gochman
      member of: UCSF Voice and Swallowing Center, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
  slot:
    index: 3
    item: Schneider SL
      type: Person
      first name: Sarah L
      last name: Schneider
      member of: UCSF Voice and Swallowing Center, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
  slot:
    index: 4
    item: Young VN
      type: Person
      first name: VyVy N
      last name: Young
      member of: UCSF Voice and Swallowing Center, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California. Electronic address: vyvy.young@ucsf.edu.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:56
e ISSN: 1873-4588
has issn l: 0892-1997
has NLM journal title abbreviation: J Voice
publication name: Journal of voice : official journal of the Voice Foundation
language: eng
has national library of medicine journal id: 8712262
derived from: NLM
has place of publication: United States
source: J Voice. 2025-01-06;():.

Generational Differences in Self-Esteem and Vocal Perception Among Brazilian Gay Men.
pmid: 39765447
abstract: Self-esteem and vocal perception are central aspects of identity and self-presentation, particularly within marginalized communities where voice and self-concept can be deeply intertwined with social acceptance and cultural dynamics. Among Brazilian gay men, generational differences in these areas may reflect broader social changes, shifts in stigma, and evolving notions of masculinity. This study aims to explore these differences, examining how self-esteem and self-assessed vocal descriptions vary across generations, thereby shedding light on specific needs and areas for potential support within these communities.To compare self-esteem and self-assessed vocal descriptions among different generations of Brazilian gay men.Observational, cross-sectional, mixed-methods study.A convenience sample of 266 Brazilian gay men completed an online survey, which included a sociodemographic questionnaire, the Rosenberg Self-Esteem Scale, and self-assessed vocal descriptive terms, between June 2 and July 14, 2023. Participants were categorized into generational groups based on age, following the definitions provided by the Pew Research Center: Baby Boomers (born 1946-1964), Generation X (born 1965-1980), Millennials (born 1981-1996), and Generation Z (born 1997-2012). Data analysis was performed using random forest techniques to identify variables relevant to generational differences and self-esteem, the frequency of descriptive terms, and multinomial logistic regression models to associate terms with self-esteem classification.Participants ranged from 18 to 71 years old, with an average age of 33.6 years. Regarding generations, 1.9% were Baby Boomers, 13.2% were Generation X, 63.2% were Millennials, and 21.8% were Generation Z. The Baby Boomer and Generation X cohorts exhibited satisfactory self-esteem, while Millennials and Generation Z showed average self-esteem. Terms such as low, good, out of tune, and effeminate were significant for Generation X; affected, pleasant, cheerfu[cell cut: 2472 characters, first 2000 kept]
rights: Copyright © 2025 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
has PII: S0892-1997(24)00422-3
doi: 10.1016/j.jvoice.2024.11.039
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Trevizani G
      type: Person
      first name: Gabriel
      last name: Trevizani
      member of: Speech-Language Pathology Department, São Paulo State University, UNESP, Av. Hygino Muzzi Filho, 737, Mirante, Marília, 17525-900, São Paulo, Brazil. Electronic address: gabrieltrevizanidepolli@gmail.com.
  slot:
    index: 2
    item: Nascimento MHC
      type: Person
      first name: Marcia Helena Cassago
      last name: Nascimento
      member of: Chemistry Department of the Federal University of Espírito Santo - UFES, Av. Mal. Campos, 1468, Maruípe, 29047-105, Vitória, Espírito Santo, Brazil. Electronic address: marcia.cassago@gmail.com.
  slot:
    index: 3
    item: Quinalha R
      type: Person
      first name: Renan
      last name: Quinalha
      member of: Paulista School of Politics, Economics, and Business, Universidade Federal de São Paulo - UNIFESP, Praça da República, 123/141, 01045-001, São Paulo, São Paulo, Brazil. Electronic address: renan.quinalha@unifesp.br.
  slot:
    index: 4
    item: Azevedo RR
      type: Person
      first name: Renata Rangel
      last name: Azevedo
      member of: Speech-Language Pathology Department, Universidade Federal de São Paulo - UNIFESP, Rua Botucatu, 802 Vila Clementino, 04023-062, São Paulo, São Paulo, Brazil. Electronic address: renata.azevedo@unifesp.br.
created: 2025-1-8T00:19
date last updated: 2025-01-07
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-7T21:56
e ISSN: 1873-4588
has issn l: 0892-1997
has NLM journal title abbreviation: J Voice
publication name: Journal of voice : official journal of the Voice Foundation
language: eng
has national library of medicine journal id: 8712262
derived from: NLM
has place of publication: United States
source: J Voice. 2025-01-06;():.

The Relationship between Diet Quality, Measured by the Recommended Food Score, and Depression, Assessed Using the Patient Health Questionnaire-9: An Observational Study in Korea.
pmid: 39765454
abstract: Depression is a prevalent mental health disorder that presents substantial public health challenges. Emerging evidence underscores the role of dietary patterns in mitigating depressive symptoms. This study investigated the association between diet quality, assessed using the Recommended Food Score (RFS), and depressive symptoms, evaluated with the Patient Health Questionnaire-9 (PHQ-9), in a sample of Korean adults.This cross-sectional study analyzed data from 19,786 participants recruited from a general hospital in Korea, all of whom completed the RFS and PHQ-9 assessments. General characteristics and anthropometric indices were recorded. Statistical analyses included chi-square tests and binary logistic regression to calculate odds ratios (ORs) and 95% confidence intervals for depressive symptoms according to RFS scores, adjusting for potential confounders.Higher RFS scores were associated with reduced odds of depression in univariate (OR, 0.59; P<0.001) and multivariate (OR, 0.72; P<0.001) analyses. Sociodemographic factors, including older age, higher education, marital status, higher income, professional occupation, and regular exercise, were linked to decreased odds of depression. Conversely, female sex, current smoking, and alcohol consumption were associated with increased odds.The findings reveal an inverse relationship between diet quality and depressive symptoms among Korean adults, emphasizing the potential of dietary improvements in mental health promotion. Sociodemographic factors significantly influence depression risk. Future studies should adopt longitudinal designs incorporating a wider range of variables to elucidate these complex interactions.
has PII: kjfm.24.0204
doi: 10.4082/kjfm.24.0204
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Choi S
      type: Person
      first name: Sharon
      last name: Choi
      member of: Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
  slot:
    index: 2
    item: Lim JS
      type: Person
      first name: Jung-Sun
      last name: Lim
      member of: Department of Family Medicine, Seoul National University SMG-SNU Boramae Medical Center, Seoul, Korea.
  slot:
    index: 3
    item: Han S
      type: Person
      first name: Sujeong
      last name: Han
      member of: Department of Family Medicine, Seoul National University SMG-SNU Boramae Medical Center, Seoul, Korea.
  slot:
    index: 4
    item: Kim JS
      type: Person
      first name: Jong Seung
      last name: Kim
      member of: Department of Family Medicine, Seoul National University SMG-SNU Boramae Medical Center, Seoul, Korea.Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
  slot:
    index: 5
    item: Oh B
      type: Person
      first name: Bumjo
      last name: Oh
      member of: Department of Family Medicine, Seoul National University SMG-SNU Boramae Medical Center, Seoul, Korea.Department of Family Medicine, Seoul National University College of Medicine, Seoul, Korea.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2025-01-08
dp: 2025 Jan 08
created: 2025-1-8T00:32
ISSN: 2005-6443
has issn l: 2005-6443
has NLM journal title abbreviation: Korean J Fam Med
publication name: Korean journal of family medicine
language: eng
has national library of medicine journal id: 101502902
derived from: NLM
has place of publication: Korea (South)
source: Korean J Fam Med. 2025-01-08;():.

Molecular Dynamics Simulations Suggest That Side-Chain Motions of Charged Amino Acids Determine Long-Range Effects in Proteins: An Egg of Coulomb.
pmid: 39769139
abstract: Living systems cannot rely on random intermolecular approaches toward cell crowding, and hidden mechanisms must be present to favor only those molecular interactions required explicitly by the biological function. Electromagnetic messaging among proteins is proposed from the observation that charged amino acids located on the protein surface are mostly in adjacent sequence positions and/or in spatial proximity. Molecular dynamics (MD) simulations have been used to predict electric charge proximities arising from concerted motions of charged amino acid side chains in two protein model systems, human ubiquitin and the chitinolytic enzyme from Ostrinia furnacalis. This choice has been made for their large difference in size and sociality. Protein electrodynamics seems to emerge as the framework for a deeper understanding of the long-distance interactions of proteins with their molecular environment. Our findings will be valuable in orienting the design of proteins with specific recognition patterns.
has PII: ijms252413375
doi: 10.3390/ijms252413375
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Niccolai N
      type: Person
      first name: Neri
      last name: Niccolai
      member of: Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  slot:
    index: 2
    item: Morandi E
      type: Person
      first name: Edoardo
      last name: Morandi
      member of: Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
  slot:
    index: 3
    item: Bernini A
      type: Person
      first name: Andrea
      last name: Bernini
      member of: Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2024-12-13
dp: 2024 Dec 13
created: 2025-1-8T01:23
e ISSN: 1422-0067
has issn l: 1422-0067
issue: 24
has NLM journal title abbreviation: Int J Mol Sci
publication name: International journal of molecular sciences
language: eng
has national library of medicine journal id: 101092791
derived from: NLM
has place of publication: Switzerland
has primary subject term: D056004
has primary subject term: D000596Q000737
has primary subject term: D025801Q000737Q000378
has subject term: D006801
has subject term: D000818
has subject term: D055672
has subject term: D011506Q000737Q000378
has subject term: D011487
source: Int J Mol Sci. 2024-12-13;25(24):.
volume: 25

Expression of concern to Ice cream cone fortified with spent coffee ground: Chemical composition, quality and sensory characteristics, and in vitro starch digestibility [Food Chem. 459 (2024) 140288].
pmid: 39772288
has PII: S0308-8146(24)04049-4
doi: 10.1016/j.foodchem.2024.142399
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: López-Silva M
      type: Person
      first name: Madai
      last name: López-Silva
      member of: Tecnológico Nacional de México/Instituto Tecnólogico Superior de Atlixco-Departamento de Ingeniería Bioquímica, Atlixco, Puebla, Mexico.
  slot:
    index: 2
    item: García-Valle DE
      type: Person
      first name: Daniel E
      last name: García-Valle
      member of: Instituto Politécnico Nacional de México, Mexico. Electronic address: daniel.garcia-valle@outlook.com.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2025-03-01
dp: 2025 03 01
created: 2025-1-8T01:45
e ISSN: 1873-7072
has issn l: 0308-8146
has NLM journal title abbreviation: Food Chem
publication name: Food chemistry
language: eng
has national library of medicine journal id: 7702639
derived from: NLM
pg: 142399
has place of publication: England
source: Food Chem. 2025-03-01;467():142399.
volume: 467

Epidemiology of caprine brucellosis in family farms in the south east of Algeria.
pmid: 39772293
abstract: This cross-sectional study aimed to estimate the seroprevalence and the potential risk factors of Brucella infection among goats in family farms in the southern east of Algeria. A total of 196 sera samples were randomly collected from 59 family farms and tested in parallel by Rose Bengal test (RBT) and indirect ELISA (iELISA). A structured questionnaire was used to collect information on potential risk factors. Apparent seroprevalence values were 8.7% (95% CI: 5.49-13.45) and 2.04% (95% CI: 0.8-5.13) for RBT and iELISA respectively. The estimated true prevalence values were 11.1% (95% CI: 6.87-17.42) for the RBT test and 1.58% (95% CI: 0.3-4.74) for iELISA. Dog presence in family farm was significantly associated with Brucella spp. seropositivity (p=0.03) using iELISA, with at least 38 times the odds of brucellosis seropositivity (OR: 38.55, 95% CI: 1.42-1049.17). Goats with previous history of stillbirth were significantly associated with Brucella spp. seropositivity (p=0.04) using RBT, with almost six (6) times higher odds (OR: 6.62, 95% CI: 1.06-41.55). Origin of animals reared on family farms was also significantly associated with Brucella spp. seropositivity (p=0.05) using iELISA with higher odds in foreign goats (OR: 12.99, 95% CI: 1.03-163.22) and lower odds in goats born in farms (OR: 0.08, 95% CI: 0.01-0.97). Based on these findings, further epidemiological studies related to the perception of the disease by animal owners and brucellosis in herding dogs needed to be conducted.
doi: 10.12834/VetIt.2572.25516.2
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ramdani N
      type: Person
      first name: Nacira
      last name: Ramdani
      member of: Management of Animal Health and Productions Laboratory, Institute of Veterinary Sciences, University of Frères Mentouri Constantine 1; Regional Veterinary Laboratory of El Oued, National Institute of Veterinary Medicine.
  slot:
    index: 2
    item: Boussena S
      type: Person
      first name: Sabrina
      last name: Boussena
      member of: Management of Animal Health and Productions Laboratory, Institute of Veterinary Sciences, University of Frères Mentouri Constantine 1. s_boussena@umc.edu.dz.
  slot:
    index: 3
    item: Ghalmi F
      type: Person
      first name: Farida
      last name: Ghalmi
      member of: Research Laboratory Management of Local Animal Resources, Higher National Veterinary School Rabie Bouchama, Algiers.
  slot:
    index: 4
    item: Benaissa MH
      type: Person
      first name: Mohammed Hocine
      last name: Benaissa
      member of: Scientific and Technical Research Center for Arid Regions (CRSTRA), Touggourt, Algeria.
  slot:
    index: 5
    item: Moula N
      type: Person
      first name: Nassim
      last name: Moula
      member of: Department of Veterinary Management of Animal Resources, Faculty of Veterinary Medicine, Liège, Belgium.
created: 2025-1-8T06:20
date last updated: 2025-01-08
issued: 2024-09-30
dp: 2024 Sep 30
created: 2025-1-8T02:59
e ISSN: 1828-1427
has issn l: 0505-401X
issue: 3
has NLM journal title abbreviation: Vet Ital
publication name: Veterinaria italiana
language: eng
has national library of medicine journal id: 0201543
derived from: NLM
has place of publication: Italy
has primary subject term: D006041
has primary subject term: D002006Q000453Q000662
has primary subject term: D015511Q000453Q000382
has subject term: D000818
has subject term: D000462Q000453
has subject term: D016036
has subject term: D003430
has subject term: D005260
has subject term: D012307
has subject term: D008297
has subject term: D015995
has subject term: D000072480Q000706
has subject term: D004797Q000662
source: Vet Ital. 2024-09-30;60(3):.
volume: 60

Human Brucellosis among the farmworkers in Cilawu and Boyolali, Indonesia.
pmid: 39772294
abstract: Brucellosis is a neglected infectious disease caused by animals and is becoming a public health problem in developing countries. There are limited case reports of human brucellosis in Indonesia because the symptoms are not specific. This study investigated the association between serological tests for brucellosis among workers and their knowledge, attitude, and behavior. The study was conducted on farmworkers in a dairy cattle milking center in Boyolali and Cilawu. A total of 149 respondents, according to the inclusion criteria, were included. Around 3 ml of blood was collected from the respondents, followed by structured interviews to determine the level of knowledge, attitudes, and behavior towards brucellosis in humans. The sera were tested with the rose bengal test (RBT) and complement fixation test (CFT). Results showed that 3.3% of respondents were positive for RBT in Boyolali and 7.01% in Cilawu. However, CFT showed that 5.3% of respondents were positive in Cilawu, but 0% in Boyolali. The level of knowledge and attitudes of respondents regarding brucellosis in humans was still lacking, and the behavior of respondents on the farm was mostly good, in the sense of understanding the procedures for maintaining healthy dairy cattle correctly, but maintaining personal health was still lacking. This study underscores the need for immediate action to improve the situation. Public health professionals, researchers, and policymakers have a crucial role in implementing regular health education programs for farmworkers and improving the availability of personal protective equipment.
doi: 10.12834/VetIt.2686.26693.3
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Novita R
      type: Person
      first name: Risqa
      last name: Novita
      member of: Primatology Study Program, IPB University, Bogor, Indonesia; Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Cibinong, Indonesia. rn_smile01@yahoo.com.
  slot:
    index: 2
    item: Nuradji H
      type: Person
      first name: Harimurti
      last name: Nuradji
      member of: Research Center of Veterinary, National Research, and Innovation Agency (BRIN), Cibinong, Indonesia.
  slot:
    index: 3
    item: Noor SM
      type: Person
      first name: Susan Maphilindawati
      last name: Noor
      member of: Research Center of Veterinary, National Research, and Innovation Agency (BRIN), Cibinong, Indonesia.
  slot:
    index: 4
    item: Prakoso D
      type: Person
      first name: Dhani
      last name: Prakoso
      member of: Professor Nidom Foundation, Surabaya, Indonesia.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2024-09-30
dp: 2024 Sep 30
created: 2025-1-8T02:59
e ISSN: 1828-1427
has issn l: 0505-401X
issue: 3
has NLM journal title abbreviation: Vet Ital
publication name: Veterinaria italiana
language: eng
has national library of medicine journal id: 0201543
derived from: NLM
has place of publication: Italy
has primary subject term: D002006Q000662Q000453
has primary subject term: D000067565Q000706Q000523
has primary subject term: D007722
has subject term: D007214Q000453
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000328
has subject term: D000818
has subject term: D002417
has subject term: D055815
has subject term: D008875
has subject term: D003612Q000706
source: Vet Ital. 2024-09-30;60(3):.
volume: 60

Comparative study of breast and intestinal microecology in lactating women with and without mastitis.
pmid: 39772301
abstract: This study sought to compare bacterial abundance and diversity in milk and feces of healthy lactating women with patients suffering from lactation mastitis, explore the pathogenesis of lactation mastitis, and develop new ideas for its treatment and prevention from a microbiological perspective. A total of 19 lactating mastitis patients and 19 healthy lactating women were recruited. Milk and fecal Specimens were obtained from both groups, and microbial community structure was analyzed using 16S rRNA gene sequencing. Our results reveal significant alternations in microbial composition and distribution of milk and feces between healthy lactating women and mastitis patients. The findings suggest that lactating mastitis patients have dysregulated gut and milk microbiota, and modulating the gut-mammary axis may be a potential strategy for preventing or treating mastitis.
rights: African Journal of Reproductive Health © 2024.
has PII: (Afr J Reprod Health 2024; 28 [12]: 97-107
doi: 10.29063/ajrh2024/v28i12.11
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Wang W
      type: Person
      first name: Wenjun
      last name: Wang
      member of: Department of First Clinical School of Medicine,Zhejiang University of Traditional Chinese Medicine ,Zhejiang, 310053.
  slot:
    index: 2
    item: Wang F
      type: Person
      first name: Fenhua
      last name: Wang
      member of: Department of Thyroid and Breast Surgery, Hangzhou linping District Maternal & Child Health Care Hospital, Zhejiang, 311113.
  slot:
    index: 3
    item: Li C
      type: Person
      first name: Chaonan
      last name: Li
      member of: Department of Thyroid and Breast Surgery,Linping Hospital of Integrated Traditional Chinese and Western Medicine,Zhejiang, 311199.
  slot:
    index: 4
    item: Xie X
      type: Person
      first name: Xiaohong
      last name: Xie
      member of: Department of Mammary gland,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang, 310006.
  slot:
    index: 5
    item: Zhu Q
      type: Person
      first name: Qi
      last name: Zhu
      member of: Department of Mammary gland,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang, 310006.
  slot:
    index: 6
    item: Fan S
      type: Person
      first name: Shuyao
      last name: Fan
      member of: Department of Mammary gland,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang, 310006.
  slot:
    index: 7
    item: Gu X
      type: Person
      first name: Xidong
      last name: Gu
      member of: Department of Mammary gland,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine), Zhejiang, 310006.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T03:47
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Cette étude visait à comparer l'abondance et la diversité bactériennes dans le lait et les selles de femmes allaitantes en bonne santé avec des patients souffrant de mammite de lactation, à explorer la pathogenèse de la mammite de lactation et à développer de nouvelles idées pour son traitement et sa prévention d'un point de vue microbiologique. Au total, 19 patientes atteintes de mammite allaitante et 19 femmes allaitantes en bonne santé ont été recrutées. Des échantillons de lait et de matières fécales ont été obtenus des deux groupes et la structure de la communauté microbienne a été analysée à l'aide du séquençage du gène de l'ARNr 16S. Nos résultats révèlent des alternances significatives dans la composition microbienne et la distribution du lait et des selles entre les femmes allaitantes en bonne santé et les patientes atteintes de mammite. Les résultats suggèrent que les patientes allaitantes atteintes d'une mammite ont un microbiote intestinal et laitier dérégulé, et que la modulation de l'axe intestin-mammaire pourrait constituer une stratégie potentielle pour prévenir ou traiter la mammite.
derived from: NLM
starting page: 97
ending page: 107
has place of publication: Nigeria
has primary subject term: D007774Q000502
has primary subject term: D008413Q000382
has primary subject term: D005243Q000382
has primary subject term: http://id.nlm.nih.gov/mesh/D000069196
has primary subject term: D008895Q000382
has primary subject term: D012336
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D001940Q000382
has subject term: D001942
has subject term: D016022
has subject term: D001419Q000302Q000145
source: Afr J Reprod Health. 2024-12-31;28(12):97-107.
volume: 28

Professional values and factors affecting these values in midwifery students.
pmid: 39772303
abstract: This study investigated the professional values of midwifery students and the factors influencing these values. Conducted from January 6 to March 6, 2021, it involved 715 midwifery students who participated voluntarily. Data was collected using a Descriptive Data Sheet and the Professional Values of Midwives Scale. Statistical analysis included descriptive statistics, two-way ANOVA, Independent Samples T Test, and Bonferroni Correction. The mean age of participants was 20.63 years; 99.2% were single, and 29.7% were second-year students. Participants mostly graduated from the following schools to Anatolian high schools (57.5%) and predominantly lived in cities (55.1%), with 81.1% from nuclear families. A significant number of parents had a primary education (mothers: 50.8%, fathers: 35.4%). The mean score on the Professional Values of Midwives Scale was high. Significant differences in scores were noted based on age, high school type, long-term residence, family type, parental education, and interest in midwifery. However, the difference was not significant found. related to academic year, willingness to choose midwifery, preference ranking, self-suitability for the profession, or shifts in perspective before and after education. These findings emphasize the multifaceted nature of professional values in midwifery students and the various factors shaping their attitudes.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 116-126
doi: 10.29063/ajrh2024/v28i12.13
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Akan A
      type: Person
      first name: Ayşenur
      last name: Akan
      member of: Midwifery Department, Faculty and Health Sciences, Ege University, Turkey.
  slot:
    index: 2
    item: Doğan RA
      type: Person
      first name: Reyhan Aydin
      last name: Doğan
      member of: Midwifery Department, Faculty and Health Sciences, Karabük University, Turkey.
created: 2025-1-8T06:20
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T04:04
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Cette étude a porté sur les valeurs professionnelles des étudiantes sages-femmes et sur les facteurs influençant ces valeurs. Menée du 6 janvier au 6 mars 2021, elle a impliqué 715 étudiantes sages-femmes qui ont participé volontairement. Les données ont été recueillies à l'aide d'une feuille de données descriptives et de l'échelle des valeurs professionnelles des sages-femmes.L'analyse statistique comprenait des statistiques descriptives, une ANOVA à deux voies, un test T des échantillons indépendants et une correction de Bonferroni. L'âge moyen des participantes était de 20,63 ans ; 99,2 % étaient célibataires et 29,7 % étaient des étudiantes de deuxième année. La plupart des participants étaient diplômés d'écoles secondaires d'Anatolie (57,5 %) et vivaient principalement en ville (55,1 %), 81,1 % d'entre eux étant issus de familles nucléaires. Un nombre important de parents avaient suivi l'enseignement primaire (mères : 50,8 %, pères : 35,4 %). Le score moyen sur l'échelle des valeurs professionnelles des sages-femmes était élevé. Des différences significatives dans les scores ont été notées en fonction de l'âge, du type d'école secondaire, de la résidence à long terme, du type de famille, de l'éducation des parents et de l'intérêt pour la profession de sage-femme. Cependant, aucune différence significative n'a été constatée en ce qui concerne l'année scolaire, la volonté de choisir la profession de sage-femme, le classement des préférences, l'aptitude personnelle à la profession ou les changements de perspective avant et après les études. Ces résultats soulignent la nature multidimensionnelle des valeurs professionnelles chez les étudiantes en pratique sage-femme et les divers facteurs qui façonnent leurs attitudes.
derived from: NLM
starting page: 116
ending page: 126
has place of publication: Nigeria
has primary subject term: D008880Q000193
has subject term: D006801
has subject term: D005260
has subject term: D055815
has subject term: D000328
has subject term: D013338Q000523Q000706
has subject term: D008297
has subject term: D011247
has subject term: D011795
has subject term: D000293
has subject term: D014421
has subject term: D012945
has subject term: D002321
has subject term: http://id.nlm.nih.gov/mesh/D000068616
source: Afr J Reprod Health. 2024-12-31;28(12):116-126.
volume: 28

Surgery for giant ovarian cysts in Guyana using single-port laparoscopy: a retrospective case series analysis.
pmid: 39772302
abstract: Giant ovarian cysts (GOCs) have become less common in developed countries due to routine health screenings, but they remain prevalent in economically underdeveloped regions. Treatment options for GOCs depend on factors such as age, cyst characteristics, and pregnancy status. Minimally invasive single-port laparoscopic surgery has largely replaced traditional open surgery due to its aesthetic advantages and effectiveness. In this case series, six patients with giant ovarian cysts, including two pregnant women, underwent single-port laparoscopic surgery. The procedure was aimed to reduce scarring, ensure safety, and preserve fertility. Strict criteria were used to rule out malignancy and assess suitability for the minimally invasive approach. Five patients had successful surgeries with positive cosmetic outcomes, while one required conversion to a mini-laparotomy due to technical difficulties. Postoperative recovery was smooth, with patients expressing satisfaction with the aesthetic results. This study demonstrates that single-port laparoscopic surgery is a safe and effective method for treating large ovarian cysts, combining the advantages of traditional laparoscopy with enhanced cosmetic results. The approach is particularly beneficial for younger and pregnant patients, with careful timing of surgery recommended to minimize pregnancy-related risks.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 108-115
doi: 10.29063/ajrh2024/v28i12.12
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: France N
      type: Person
      first name: Natasha
      last name: France
      member of: Department of Obstetrics and Gynecology, Georgetown Public Hospital Corporation,Georgetown, Guyana.
  slot:
    index: 2
    item: Sookraj R
      type: Person
      first name: Radha
      last name: Sookraj
      member of: Department of Obstetrics and Gynecology, Georgetown Public Hospital Corporation,Georgetown, Guyana.
  slot:
    index: 3
    item: Gittens S
      type: Person
      first name: Sabrina
      last name: Gittens
      member of: Department of Obstetrics and Gynecology, Georgetown Public Hospital Corporation,Georgetown, Guyana.
  slot:
    index: 4
    item: Jiang Y
      type: Person
      first name: Yuan
      last name: Jiang
      member of: Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing , China.
created: 2025-1-8T06:20
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T03:56
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Les kystes ovariens géants (GOC) sont devenus moins courants dans les pays développés en raison des examens médicaux de routine, mais ils restent répandus dans les régions économiquement sous-développées. Les options de traitement pour les GOC dépendent de facteurs tels que l'âge, les caractéristiques du kyste et l'état de grossesse. La chirurgie laparoscopique mini-invasive à un seul port a largement remplacé la chirurgie ouverte traditionnelle en raison de ses avantages esthétiques et de son efficacité. Dans cette série de cas, six patientes présentant des kystes ovariens géants, dont deux femmes enceintes, ont subi une chirurgie laparoscopique à un seul port. La procédure visait à réduire les cicatrices, à assurer la sécurité et à préserver la fertilité. Des critères stricts ont été utilisés pour exclure la malignité et évaluer l’adéquation de l’approche mini-invasive. Cinq patients ont subi des interventions chirurgicales réussies avec des résultats esthétiques positifs, tandis qu'un a dû être converti en mini-laparotomie en raison de difficultés techniques. La récupération postopératoire s'est déroulée sans problème, les patients exprimant leur satisfaction quant aux résultats esthétiques. Cette étude démontre que la chirurgie laparoscopique à port unique est une méthode sûre et efficace pour traiter les gros kystes ovariens, combinant les avantages de la laparoscopie traditionnelle avec des résultats cosmétiques améliorés. L'approche est particulièrement bénéfique pour les patientes plus jeunes et enceintes, avec un timing minutieux de l'intervention chirurgicale recommandé pour minimiser les risques liés à la grossesse.
derived from: NLM
starting page: 108
ending page: 115
has place of publication: Nigeria
has primary subject term: D010535Q000379
has primary subject term: D010048Q000601
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D012189
has subject term: D011247
has subject term: D016896
has subject term: D055815
source: Afr J Reprod Health. 2024-12-31;28(12):108-115.
volume: 28

Causal association between gut microbiome and polycystic ovary syndrome: A bidirectional Mendelian randomization study.
pmid: 39772304
abstract: Through implementing a bidirectional Mendelian randomization (MR) study, the causal effects between gut microbiome and polycystic ovary syndrome (PCOS) were analyzed. Summary statistics for PCOS were acquired from the FinnGen consortium R8 release data, which included 27,943 cases and 162,936 controls. The inverse-variance weighting (IVW) method was adopted for analysis. Additionally, the causality involving exposure plus the outcome was evaluated by means of MR-Egger, weighted median, simple mode methods, as well as weighted mode. The IVW estimate showed that the genera Streptococcus plus Enterorhabdus served as protectors of PCOS. By contrast, the phylum Tenericutes, genera Anaerofilum, Coprococcus 2, Lachnospiraceae ND3007 group and Ruminiclostridium 5 were identified as risk elements of PCOS. Based on reverse MR analyses from PCOS on the intestinal microbiome based on the IVW method, the phyla Tenericutes, Actinobacteria, class Actinobacteria, genera Ruminococcaceae UCG004 and Christensenellaceae R 7group exhibited a down-regulation effect after PCOS onset. The genera Bacteroides, Barnesiella, Erysipelotrichaceae UCG003, Ruminococcus gnavus group, and Veillonella were up-regulated. No horizontal pleiotropy or significant IV heterogeneity was observed. We conclude that there is a causality relationship between gut microbiome and PCOS, where some bacterial taxa can be used as biomarkers to promote targeted diagnosis and therapy for PCOS.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 127-138
doi: 10.29063/ajrh2024/v28i12.14
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Xia D
      type: Person
      first name: Dongqin
      last name: Xia
      member of: Department of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu, China.Rugao Maternity Hospital, Rugao 226500, Jiangsu, China.
  slot:
    index: 2
    item: Xu L
      type: Person
      first name: Linjie
      last name: Xu
      member of: Department of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu, China.
  slot:
    index: 3
    item: Cheng X
      type: Person
      first name: Xi
      last name: Cheng
      member of: Department of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu, China.
  slot:
    index: 4
    item: Li C
      type: Person
      first name: Chenglu
      last name: Li
      member of: Department of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu, China.
  slot:
    index: 5
    item: Chen S
      type: Person
      first name: Siyi
      last name: Chen
      member of: Department of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu, China.
  slot:
    index: 6
    item: Zhang Y
      type: Person
      first name: Yuquan
      last name: Zhang
      member of: Department of Gynecology and Obstetrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu, China.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T04:14
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Grâce à la mise en œuvre d’une étude de randomisation mendélienne (MR) bidirectionnelle, les effets causals entre le microbiome intestinal et le syndrome des ovaires polykystiques (SOPK) ont été analysés. Les statistiques récapitulatives sur le SOPK ont été acquises à partir des données de diffusion R8 du consortium FinnGen, qui comprenaient 27 943 cas et 162 936 contrôles. La méthode de pondération de variance inverse (IVW) a été adoptée pour l'analyse. De plus, la causalité impliquant l'exposition et le résultat a été évaluée au moyen des méthodes MR-Egger, de la médiane pondérée, du mode simple, ainsi que du mode pondéré. L'estimation IVW a montré que les genres Streptococcus et Enterorhabdus servaient de protecteurs du SOPK. En revanche, le phylum Tenericutes, les genres Anaerofilum, Coprococcus 2, le groupe Lachnospiraceae ND3007 et Ruminiclostridium 5 ont été identifiés comme éléments de risque du SOPK. Sur la base d'analyses IRM inverse du SOPK sur le microbiome intestinal basées sur la méthode IVW, les phyla Tenericutes, Actinobacteria, classe Actinobacteria, genres Ruminococcaceae UCG004 et Christensenellaceae R 7group ont présenté un effet de régulation négative après l'apparition du SOPK. Les genres Bacteroides, Barnesiella, Erysipelotrichaceae UCG003, le groupe Ruminococcus gnavus et Veillonella étaient régulés positivement. Aucune pléiotropie horizontale ni hétérogénéité IV significative n’a été observée. Nous concluons qu’il existe une relation de causalité entre le microbiome intestinal et le SOPK, certains taxons bactériens pouvant être utilisés comme biomarqueurs pour promouvoir un diagnostic et un traitement ciblés du SOPK.
derived from: NLM
starting page: 127
ending page: 138
has place of publication: Nigeria
has primary subject term: D011085Q000382
has primary subject term: D057182
has primary subject term: http://id.nlm.nih.gov/mesh/D000069196
has subject term: D006801
has subject term: D005260
source: Afr J Reprod Health. 2024-12-31;28(12):127-138.
volume: 28

Socio-cultural drivers and barriers to addressing repeat teenage pregnancies and early child /forced marriages in Central and Eastern Uganda.
pmid: 39772306
abstract: With 25% of teenagers pregnant by age of 19 and about half of these married before their 18th birth day, Uganda exhibits one of the highest rates of teenage pregnancy and child marriage globally. Comprehensive data on the drivers and barriers to addressing repeat teenage pregnancies and early child marriages remains limited. Using the narrative inquiry approach, the paper explores the key socio-cultural drivers and barriers to addressing repeat teenage pregnancies and early/forced marriages among stakeholders in the districts of Mbale, Kween, Namayingo and Kalangala. Guided by purposive sampling, a total of 125 qualitative interviews (80 key informant interviews (KIIs) and 45 focus group discussions (FGDs) were conducted. Data analysis was done using deductive thematic analysis in Atlas ti software. The drives of repeat teenage pregnancy (RPT) include the distorted community understanding of repeat teenage pregnancy; poverty at the household; norms, traditions and beliefs; cultural and traditional practices; lack of comprehensive sex education, school dropout, Peer pressure and influence, and vulnerable populations. The results point to a strong relationship between teenage pregnancy, early child/forced marriage and repeat teenage pregnancy across all the four districts and to poverty as the driving force.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 148-164
doi: 10.29063/ajrh2024/v28i12.16
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Muyonga M
      type: Person
      first name: Michael
      last name: Muyonga
      member of: Heroes for Gender Transformative Action - Amref Health Africa, Uganda.
  slot:
    index: 2
    item: Kagurusi P
      type: Person
      first name: Patrick
      last name: Kagurusi
      member of: Amref Health Africa, Uganda.
  slot:
    index: 3
    item: Nankanja M
      type: Person
      first name: Maureen
      last name: Nankanja
      member of: Amref Health Africa, Uganda.
  slot:
    index: 4
    item: Ayanga I
      type: Person
      first name: Irene
      last name: Ayanga
      member of: Heroes for Gender Transformative Action - Amref Health Africa, Uganda.
  slot:
    index: 5
    item: Kampire P
      type: Person
      first name: Pamela
      last name: Kampire
      member of: Gender Equality and Social Inclusion Specialist DT Global, Indonesia.
  slot:
    index: 6
    item: Tigaiza A
      type: Person
      first name: Arnold
      last name: Tigaiza
      member of: Makerere University School of Public Health, Uganda.
  slot:
    index: 7
    item: Nabacwa MS
      type: Person
      first name: Mary S
      last name: Nabacwa
      member of: Heroes for Gender Transformative Action - Amref Health Africa, Uganda.
created: 2025-1-8T06:20
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T04:38
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Avec 25 % des adolescentes enceintes avant l’âge de 19 ans et environ la moitié d’entre elles mariées avant leur 18e jour de naissance, l’Ouganda présente l’un des taux de grossesses et de mariages d’enfants les plus élevés au monde. Les données complètes sur les facteurs déterminants et les obstacles à la lutte contre les grossesses répétées chez les adolescentes et les mariages précoces d’enfants restent limitées. En utilisant l'approche d'enquête narrative, l'article explore les principaux facteurs socioculturels et les obstacles à la lutte contre les grossesses répétées chez les adolescentes et les mariages précoces/forcés parmi les parties prenantes des districts de Mbale, Kween, Namayingo et Kalangala. Guidés par un échantillonnage raisonné, un total de 125 entretiens qualitatifs (80 entretiens avec des informateurs clés (KII) et 45 discussions de groupe (FGD) ont été menés. L'analyse des données a été effectuée à l'aide d'une analyse thématique déductive dans le logiciel Atlas ti. Les motivations des grossesses répétées chez les adolescentes ( RPT) comprennent la compréhension déformée par la communauté des grossesses répétées chez les adolescentes ; la pauvreté au sein des ménages ; le manque d'éducation sexuelle complète, l'abandon scolaire et la pression des pairs ; et d'influence, ainsi que les populations vulnérables. Les résultats mettent en évidence une relation étroite entre les grossesses précoces, les mariages précoces/forcés et les grossesses répétées chez les adolescentes dans les quatre districts, ainsi que la pauvreté comme force motrice..
derived from: NLM
starting page: 148
ending page: 164
has place of publication: Nigeria
has primary subject term: D011253Q000208Q000706
has primary subject term: D008393Q000208
has primary subject term: D017144
has primary subject term: D036301
has subject term: D006801
has subject term: D011247
has subject term: D005260
has subject term: D000293
has subject term: D014454
has subject term: D055815
has subject term: D003469
has subject term: D011203
has subject term: D008297
has subject term: D012736
has subject term: D007407
has subject term: D007722
has subject term: D000328
source: Afr J Reprod Health. 2024-12-31;28(12):148-164.
volume: 28

Cloud computing practice activities and mental capacity on developing reproductive health and cognitive absorption.
pmid: 39772309
abstract: The current study aims to determine how the interactions between practice (distributed/focused) and mental capacity (high/low) in the cloud-computing environment (CCE) affect the development of reproductive health skills and cognitive absorption. The study employed an experimental design, and it included a categorical variable for mental capacity (low/high) and an independent variable with two types of activities (distributed/focused). The research sample consisted of 240 students from the College of Science and College of Applied Medical Sciences at the University of Hail's. The sample was divided into four experimental groups. The study's most significant findings were the CCE's apparent favoritism of the group that studied using focused practice style and high mental capacity in the reproductive health skills test, as opposed to distributed practice style and low mental capacity in cognitive absorption. The findings will add to the ongoing debate over which of the two distributed/focused practice activity models is more effective in achieving desired educational results.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [28 [12]: 186-200
doi: 10.29063/ajrh2024/v28i12.19
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ibrahem UM
      type: Person
      first name: Usama M
      last name: Ibrahem
      member of: Ha'il University, Kingdom of Saudi Arabia.Suez Canal University, Egypt.
  slot:
    index: 2
    item: Alblaihed MA
      type: Person
      first name: Munthir A
      last name: Alblaihed
      member of: Ha'il University, Kingdom of Saudi Arabia.
  slot:
    index: 3
    item: Altamimi AB
      type: Person
      first name: Ahmed B
      last name: Altamimi
      member of: Ha'il University, Kingdom of Saudi Arabia.
  slot:
    index: 4
    item: Alqirnas HR
      type: Person
      first name: Hind R
      last name: Alqirnas
      member of: Ha'il University, Kingdom of Saudi Arabia.
  slot:
    index: 5
    item: Mahmoud SM
      type: Person
      first name: Shawky M
      last name: Mahmoud
      member of: Suez Canal University, Egypt.
  slot:
    index: 6
    item: Salem MI
      type: Person
      first name: Magdy I
      last name: Salem
      member of: Suez Canal University, Egypt.
  slot:
    index: 7
    item: Alsaadany M
      type: Person
      first name: Mohamed
      last name: Alsaadany
      member of: Port Said University, Egypt.
created: 2025-1-8T06:20
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T05:17
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: L'étude visait à étudier les attentes de performance dans les tâches futures basées sur la gestion de l'apprentissage personnel pendant l'épidémie de Corona. Un échantillon aléatoire de 871 étudiants de l'Université de Hail a été sélectionné. Les échantillons de l’étude provenaient de facultés de sciences humaines, d’ingénierie et de médecine. L’étude était basée sur une conception d’étude transversale. L'étude a préparé une mesure des attentes futures en matière de performance pour les tâches. L'échelle est de 28 items. L'analyse factorielle a été utilisée pour vérifier la validité de l'échelle, et celle-ci a atteint des indicateurs acceptables de bon ajustement. L'échelle a atteint une stabilité acceptable en utilisant le coefficient alpha de Cronbach pour le facteur émotionnel de 0,57, le facteur cognitif de 0,94 et le facteur comportemental de 0,90. Les résultats ont révélé qu’il existe des différences dans les attentes futures en matière de performance en raison du sexe et du type d’université. Les résultats ont révélé qu’il existe des corrélations positives entre les attentes futures en matière de performances cognitives et émotionnelles, ainsi qu’une relation positive entre les performances émotionnelles et comportementales. Il existe également une relation négative entre les performances comportementales et cognitives.
derived from: NLM
starting page: 186
ending page: 200
has place of publication: Nigeria
has primary subject term: D060728
has primary subject term: D003071
has primary subject term: http://id.nlm.nih.gov/mesh/D000067917
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D055815
has subject term: D013334Q000523
has subject term: D000328
has subject term: D016743
source: Afr J Reprod Health. 2024-12-31;28(12):186-200.
volume: 28

Effects of transurethral 0bipolar plasma prostatectomy on urodynamics and sexual function in patients with prostatic hyperplasia.
pmid: 39772310
abstract: This was an original article, and the objective of this study was to investigate the effects of bipolar transurethral plasma kinetic prostatectomy (TUPKP) on urodynamics and sexual function in benign prostatic hyperplasia (BPH) patients. One hundred and four BPH patients were divided into a control group and an intervention group. The control group received transurethral resection of prostate, while the intervention group received TUKEP. Relative to the control group, the intervention group presented less intraoperative blood loss and shorter bladder irrigation time, catheter retention time, and shorter hospital stay. Three months after surgery, the improvements of maximum urine flow rate (Qmax), pressure-flow rate (A-G) and residual urine volume (RV) in intervention group were more obvious than control group. One month after surgery, relative to control group, the intervention group had lower C-reactive protein (CRP), epinephrine (E) along with cortisol (Cor), cyclo-oxygenase 2 (COX-2) and vascular endothelial growth factor (VEGF) levels. On day 7 after surgery, PSA, EGF, and PGE2 levels in the intervention group were lower when compared to the control group. We conclude that TUKEP can diminish intraoperative blood loss, promote postoperative recovery, improve postoperative urodynamics and sexual function, and improve prognosis of BPH patients.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 201-210
doi: 10.29063/ajrh2024/v28i12.20
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yao X
      type: Person
      first name: Xiuju
      last name: Yao
      member of: Department of Medical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.Department of Clinical Laboratory, 363 Hospital, Chengdu, Sichuan 610016, China.
  slot:
    index: 2
    item: Den Q
      type: Person
      first name: Qiuping
      last name: Den
      member of: Department of Medical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.Department of Clinical Laboratory, Maternity and Children's Health Care Hospital of Jinjiang District, Chengdu, Sichuan 610016, China.
  slot:
    index: 3
    item: Ll G
      type: Person
      first name: Guangquan
      last name: Ll
      member of: Department of Clinical Laboratory, 363 Hospital, Chengdu, Sichuan 610016, China.
  slot:
    index: 4
    item: Guo Y
      type: Person
      first name: Yuanbiao
      last name: Guo
      member of: Department of Medical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.Medical Research Center, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T05:28
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: Il s'agissait d'un article original et l'objectif de cette étude était d'étudier les effets de la prostatectomie cinétique plasmatique transurétrale bipolaire (TUPKP) sur l'urodynamique et la fonction sexuelle chez les patients atteints d'hyperplasie bénigne de la prostate (HBP). Cent quatre patients atteints d'HBP ont été répartis en un groupe témoin et un groupe d'intervention. Le groupe témoin a reçu une résection transurétrale de la prostate, tandis que le groupe d'intervention a reçu TUKEP. Par rapport au groupe témoin, le groupe d'intervention présentait moins de pertes sanguines peropératoires, un temps d'irrigation de la vessie, un temps de rétention du cathéter et un séjour à l'hôpital plus courts. Trois mois après la chirurgie, les améliorations du débit urinaire maximal (Qmax), du débit pression-débit (A-G) et du volume urinaire résiduel (RV) dans le groupe d'intervention étaient plus évidentes que dans le groupe témoin. Un mois après la chirurgie, par rapport au groupe témoin, le groupe d'intervention présentait des taux de protéine C-réactive (CRP), d'épinéphrine (E) ainsi que de cortisol (Cor), de cyclo-oxygénase 2 (COX-2) et de facteur de croissance endothélial vasculaire (VEGF) plus faibles. ) niveaux. Au jour 7 après la chirurgie, les niveaux de PSA, d'EGF et de PGE2 dans le groupe d'intervention étaient inférieurs à ceux du groupe témoin. Nous concluons que TUKEP peut diminuer la perte de sang peropératoire, favoriser la récupération postopératoire, améliorer l'urodynamique et la fonction sexuelle postopératoires et améliorer le pronostic des patients atteints d'HBP.
derived from: NLM
starting page: 201
ending page: 210
has place of publication: Nigeria
has primary subject term: D011470Q000601
has primary subject term: D014563
has primary subject term: D020728
has subject term: D006801
has subject term: D008297
has subject term: D000368
has subject term: D008875
has subject term: D011468Q000379
has subject term: D016896
source: Afr J Reprod Health. 2024-12-31;28(12):201-210.
volume: 28

Assessment of awareness, knowledge, and usage of folic acid among females in Jazan Region, Saudi Arabia.
pmid: 39772308
abstract: Folic acid (FA) plays a crucial role in various biological processes. Insufficient intake of FA during pregnancy can lead to serious clinical complications, including neural tube defect. The current study sought to assess the awareness, knowledge, and usage of FA among young females in Jazan region of Saudi Arabia. This cross-sectional descriptive study involved 472 adult females from October 1 to 9, 2023, in Jazan region, Saudi Arabia. The questionnaire of the study was randomly distributed among females. The data showed that awareness and usage of FA supplementation were poor to fair among females. Furthermore, socio-demographic variables, including age, marital status, monthly income, education levels, number of pregnancies, and current pregnancy status, were found to be associated with awareness and utilization of FA supplementation. The study highlights the need to enhance awareness and knowledge of FA supplementation among females in the Jazan region. Introducing educational programs is essential in Saudi Arabia, particularly in the Jazan region, to enhance the knowledge and awareness of FA within the community.
rights: African Journal of Reproductive Health © 2024.
has PII: Afr J Reprod Health 2024; 28 [12]: 175-185
doi: 10.29063/ajrh2024/v28i12.18
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Dobie G
      type: Person
      first name: Gasim
      last name: Dobie
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 2
    item: Al-Hazazi N
      type: Person
      first name: Nouf
      last name: Al-Hazazi
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 3
    item: Nahari M
      type: Person
      first name: Maram
      last name: Nahari
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 4
    item: Sabyani AM
      type: Person
      first name: Areej M
      last name: Sabyani
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 5
    item: Essawi K
      type: Person
      first name: Khaled
      last name: Essawi
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 6
    item: Mobarki AA
      type: Person
      first name: Abdullah A
      last name: Mobarki
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 7
    item: Hakami W
      type: Person
      first name: Waleed
      last name: Hakami
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 8
    item: Alqahtani NA
      type: Person
      first name: Naema A
      last name: Alqahtani
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 9
    item: Almalki BM
      type: Person
      first name: Bandar M
      last name: Almalki
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 10
    item: Farah AM
      type: Person
      first name: Asma M
      last name: Farah
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 11
    item: Hakami AM
      type: Person
      first name: Adel M
      last name: Hakami
      member of: Jazan University Hospital, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 12
    item: Musawi S
      type: Person
      first name: Shaqraa
      last name: Musawi
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 13
    item: Alhakami FA
      type: Person
      first name: Fatemah A
      last name: Alhakami
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 14
    item: Alfoud MY
      type: Person
      first name: Mohamed Y
      last name: Alfoud
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 15
    item: Alyahyawi Y
      type: Person
      first name: Yara
      last name: Alyahyawi
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 16
    item: Madkhali AM
      type: Person
      first name: Aymen M
      last name: Madkhali
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 17
    item: Hakamy A
      type: Person
      first name: Ali
      last name: Hakamy
      member of: Nursing Department, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 18
    item: Chandika R
      type: Person
      first name: Rama
      last name: Chandika
      member of: Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 19
    item: Saboor M
      type: Person
      first name: Muhammad
      last name: Saboor
      member of: Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirate.
  slot:
    index: 20
    item: Hanin A
      type: Person
      first name: Amnah
      last name: Hanin
      member of: Pediatric ward, Baish General Hospital, Jazan Health Affairs, Jazan, Saudi Arabia.
  slot:
    index: 21
    item: Akhter MS
      type: Person
      first name: Mohammad S
      last name: Akhter
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
  slot:
    index: 22
    item: Hamali HA
      type: Person
      first name: Hassan A
      last name: Hamali
      member of: Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
created: 2025-1-8T06:21
date last updated: 2025-01-08
issued: 2024-12-31
dp: 2024 Dec 31
created: 2025-1-8T05:06
ISSN: 1118-4841
has issn l: 1118-4841
issue: 12
has NLM journal title abbreviation: Afr J Reprod Health
publication name: African journal of reproductive health
language: eng
has national library of medicine journal id: 9712263
rights holder: L'acide folique (AF) joue un rôle crucial dans divers processus biologiques. Un apport insuffisant en AF pendant la grossesse peut entraîner de graves complications cliniques, notamment une anomalie du tube neural. La présente étude visait à évaluer la sensibilisation, les connaissances et l'utilisation de l'AF chez les jeunes femmes de la région de Jazan en Arabie Saoudite. Cette étude descriptive transversale a porté sur 472 femmes adultes, menée du 1er au 9 octobre 2023, dans la région de Jazan, en Arabie Saoudite. Le questionnaire de l'étude a été distribué au hasard parmi les femmes. Les données ont montré que la sensibilisation et l'utilisation de la supplémentation en AG étaient faibles à passables chez les femmes. En outre, des variables sociodémographiques, notamment l'âge, l'état civil, le revenu mensuel, le niveau d'éducation, le nombre de grossesses et l'état actuel de la grossesse, se sont révélées associées à la connaissance et à l'utilisation de la supplémentation en AG. L'étude met en évidence la nécessité d'améliorer la sensibilisation et les connaissances sur la supplémentation en AG chez les femmes de la région de Jazan. L'introduction de programmes éducatifs est essentielle en Arabie Saoudite, en particulier dans la région de Jazan, pour améliorer les connaissances et la sensibilisation à l'AF au sein de la communauté.
derived from: NLM
starting page: 175
ending page: 185
has place of publication: Nigeria
has primary subject term: D005492Q000008
has primary subject term: D007722
has primary subject term: D019587
has primary subject term: D009436Q000517
has subject term: D006801
has subject term: D005260
has subject term: D012529
has subject term: D000328
has subject term: D003430
has subject term: D011247
has subject term: D011795
has subject term: D055815
has subject term: D012959
has subject term: D000293
has subject term: D011295Q000706
source: Afr J Reprod Health. 2024-12-31;28(12):175-185.
volume: 28

Mycoplasma genitalium: An emerging superbug among men having sex with men.
pmid: 39772313
has PII: 10.25259/IJDVL_861_2024
doi: 10.25259/IJDVL_861_2024
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Juyal D
      type: Person
      first name: Deepak
      last name: Juyal
      member of: Department of Microbiology, Government Doon Medical College, Dehrakhas, Patel Nagar, Dehradun, India.
  slot:
    index: 2
    item: Sethi S
      type: Person
      first name: Sunil
      last name: Sethi
      member of: Department of Microbiology, PGIMER, Chandigarh, India.
  slot:
    index: 3
    item: Dhawan N
      type: Person
      first name: Neha
      last name: Dhawan
      member of: Department of Dermatology, Venereology & Leprosy, Osmania General Hospital, Begum Bazar, Afzal Ganj, Hyderabad, India.
  slot:
    index: 4
    item: Gupta S
      type: Person
      first name: Somesh
      last name: Gupta
      member of: Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
  slot:
    index: 5
    item: Dhawan B
      type: Person
      first name: Benu
      last name: Dhawan
      member of: Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
created: 2025-1-8T06:21
date last updated: 2025-01-08
created: 2025-1-8T05:48
e ISSN: 0973-3922
has issn l: 0378-6323
issue: 1
has NLM journal title abbreviation: Indian J Dermatol Venereol Leprol
publication name: Indian journal of dermatology, venereology and leprology
language: eng
has national library of medicine journal id: 7701852
derived from: NLM
starting page: 136
ending page: 137
has place of publication: United States
source: Indian J Dermatol Venereol Leprol. ;91(1):136-137.
volume: 91

The Importance of Age Standardisation in Comparing Regional Inequalities.
pmid: 39772317
doi: 10.4274/balkanmedj.galenos.2024.2024-10-40
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Emek M
      type: Person
      first name: Mestan
      last name: Emek
      member of: Department of Public Health, Akdeniz University Faculty of Medicine, Antalya, Türkiye.
created: 2025-1-8T12:23
date last updated: 2025-01-08
issued: 2025-01-08
dp: 2025 Jan 08
created: 2025-1-8T06:22
e ISSN: 2146-3131
has issn l: 2146-3123
has NLM journal title abbreviation: Balkan Med J
publication name: Balkan medical journal
language: eng
has national library of medicine journal id: 101571817
derived from: NLM
has place of publication: Turkey
source: Balkan Med J. 2025-01-08;():.

Authors' reply.
pmid: 39772311
has PII: 10.25259/IJDVL_1831_2024
doi: 10.25259/IJDVL_1831_2024
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Tandon D
      type: Person
      first name: Deepti
      last name: Tandon
      member of: Department of Clinical Research, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, Maharashtra, India.
  slot:
    index: 2
    item: Singh A
      type: Person
      first name: Arpita
      last name: Singh
      member of: Department of Municipal STD Clinic & ART Centre, Nagpada, Brihanmumbai Municipal Cooperation, Mumbai, Maharashtra, India.
  slot:
    index: 3
    item: Kerkar S
      type: Person
      first name: Shilpa
      last name: Kerkar
      member of: Department of Child Health Research, ICMR-National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, Maharashtra, India.
  slot:
    index: 4
    item: Sawant S
      type: Person
      first name: Sandhya
      last name: Sawant
      member of: Department of Microbiology, Regional STI Training Research and Reference Laboratory, TNMC & BYL Nair Charitable Hospital Mumbai, Mumbai, Maharashtra, India.
  slot:
    index: 5
    item: Trymbhake V
      type: Person
      first name: Varsha
      last name: Trymbhake
      member of: Department of Abhyudayanagar Clinic, ICMR-National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, Maharashtra, India.
  slot:
    index: 6
    item: Munne K
      type: Person
      first name: Kiran
      last name: Munne
      member of: Department of Child Health Research, ICMR-National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, Maharashtra, India.
  slot:
    index: 7
    item: Begum S
      type: Person
      first name: Shahina
      last name: Begum
      member of: Department of Biostatistics, National Institute for Research in Reproductive Health, Mumbai, Maharashtra, India.
  slot:
    index: 8
    item: Patil AD
      type: Person
      first name: Anushree Devashish
      last name: Patil
      member of: Department of Clinical Research, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, Maharashtra, India.
  slot:
    index: 9
    item: Shastri J
      type: Person
      first name: Jayanthi
      last name: Shastri
      member of: Department of Microbiology, T.N. Medical College & B Y L Nair Ch. Hospital Mumbai, Mumbai, Maharashtra, India.
  slot:
    index: 10
    item: Acharya S
      type: Person
      first name: Shrikala
      last name: Acharya
      member of: Department of Community Medicine, Seth GSMC & KEMH, MBBS, MD (Community Medicine), Mumbai, Maharashtra, India.
  slot:
    index: 11
    item: Surve S
      type: Person
      first name: Suchitra
      last name: Surve
      member of: Department of Child Health Research, ICMR-National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, Maharashtra, India.
created: 2025-1-8T06:20
date last updated: 2025-01-08
created: 2025-1-8T05:48
e ISSN: 0973-3922
has issn l: 0378-6323
issue: 1
has NLM journal title abbreviation: Indian J Dermatol Venereol Leprol
publication name: Indian journal of dermatology, venereology and leprology
language: eng
has national library of medicine journal id: 7701852
derived from: NLM
starting page: 137
ending page: 138
has place of publication: United States
source: Indian J Dermatol Venereol Leprol. ;91(1):137-138.
volume: 91

Gender equity in Indian dermatology: Are we moving in the right direction?
pmid: 39772312
has PII: 10.25259/IJDVL_1885_2024
doi: 10.25259/IJDVL_1885_2024
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Singal A
      type: Person
      first name: Archana
      last name: Singal
      member of: Department of Dermatology & STD, University College of Medical Sciences & GTB Hospital, Delhi, India.
created: 2025-1-8T06:21
date last updated: 2025-01-08
created: 2025-1-8T05:48
e ISSN: 0973-3922
has issn l: 0378-6323
issue: 1
has NLM journal title abbreviation: Indian J Dermatol Venereol Leprol
publication name: Indian journal of dermatology, venereology and leprology
language: eng
has national library of medicine journal id: 7701852
derived from: NLM
starting page: 1
ending page: 2
has place of publication: United States
source: Indian J Dermatol Venereol Leprol. ;91(1):1-2.
volume: 91

Commentator Discussion: The impact of epiaortic ultrasound utilization in patients undergoing coronary artery bypass grafting.
pmid: 39772336
has PII: S0022-5223(24)01124-3
doi: 10.1016/j.jtcvs.2024.12.003
created: 2025-1-8T12:23
date last updated: 2025-01-08
issued: 2025-01-06
dp: 2025 Jan 06
created: 2025-1-8T10:32
e ISSN: 1097-685X
has issn l: 0022-5223
has NLM journal title abbreviation: J Thorac Cardiovasc Surg
publication name: The Journal of thoracic and cardiovascular surgery
language: eng
has national library of medicine journal id: 0376343
derived from: NLM
has place of publication: United States
source: J Thorac Cardiovasc Surg. 2025-01-06;():.

Sex Differences in Rates of Spinal Cord Stimulation Therapy and Spinal Cord Stimulator Explants: A Propensity-Score Matched Analysis.
pmid: 39772340
abstract: Spinal cord stimulation (SCS) is a therapeutic option for those with chronic pain due to persistent spinal pain syndrome (PSPS). Current literature suggests a higher rate of SCS explant in female patients, but evidence regarding sex differences in the rates of receiving SCS therapy is limited. We do not know whether there is a disparity between female and male patients who receive SCS therapy. The objectives of this retrospective analysis were to determine whether there is a sex-based disparity in SCS therapy and SCS explants between female and male patients for the treatment of PSPS.This retrospective study included medical record data from TriNetX US collaborative research network (TriNetX, Inc, Cambridge, MA), which included 61 large US healthcare organizations. Patients with a diagnosis of PSPS were identified. From the PSPS cohort, those who received SCS therapy (leads and/or generator) were included for the primary outcome, which was to compare the rates of SCS therapy in women and men, and those who received SCS explants were included for the secondary outcome. Propensity matched scoring was used to ensure comparability of cohorts.The propensity-score matched sample included 87,681 female and 87,681 male patients for analysis, with SCS therapy being provided to 6782 women (risk of 7.735%) and 6783 men (risk of 7.736%), with a risk difference of -0.001%, 95% CI (-0.251%, 0.249%), z = -0.009, p = 0.9929. Within the same propensity-score matched sample, SCS explant occurred in 2999 women (risk of 3.420%) and 2608 men (risk of 2.974%). The risk difference was 0.446%, 95% CI (0.281%, 0.611%), z = 5.307, p < 0.0001.Our retrospective analysis shows that there is not a difference in the rates of SCS therapy between a matched sample of women and men with PSPS, and a small difference in rates of SCS explants between women and men.
rights: Copyright © 2024 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.
has PII: S1094-7159(24)01268-6
doi: 10.1016/j.neurom.2024.12.002
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Grabnar M
      type: Person
      first name: Maria
      last name: Grabnar
      member of: MetroHealth Rehabilitation Institute, Metrohealth System, Cleveland, OH, USA; Department of Physical Medicine and Rehabilitation, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: mgrabnar@metrohealth.org.
  slot:
    index: 2
    item: Wilson R
      type: Person
      first name: Richard
      last name: Wilson
      member of: MetroHealth Rehabilitation Institute, Metrohealth System, Cleveland, OH, USA; Department of Physical Medicine and Rehabilitation, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
created: 2025-1-8T12:23
date last updated: 2025-01-08
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-8T10:32
e ISSN: 1525-1403
has issn l: 1094-7159
has NLM journal title abbreviation: Neuromodulation
publication name: Neuromodulation : journal of the International Neuromodulation Society
language: eng
has national library of medicine journal id: 9804159
derived from: NLM
has place of publication: United States
source: Neuromodulation. 2025-01-07;():.

Optimizing Physical Assessment in Intrathecal Baclofen Screening Trials for High-Performing Patients With Spastic Paraparesis.
pmid: 39772339
abstract: Intrathecal baclofen (ITB) therapy is well documented as an effective treatment option for severe spasticity. Before ITB implantation, trials are conducted to evaluate efficacy, safety, and candidate suitability. While many centers conduct ITB trials, appropriate physical assessment has not been fully established. This study aimed to identify useful physical assessments for ITB trials in spastic paraparesis.Patients with spasticity who experienced paraplegia for at least 12 months and underwent ITB trials in Chiba University Hospital were included. Physical functions were assessed before ITB administration and 4 hours after ITB injection on each day of the ITB trial. Physical assessments included targeted neurological and musculoskeletal tests (modified Ashworth scale, deep tendon reflexes, clonus, active range of motion, and manual muscle test) and mobility tests (Berg Balance Scale, Timed Up and Go Test [TUG], 10-Meter Walk Test, and step length).A total of 22 patients underwent ITB trials. Among the physical assessments, the Modified Ashworth Scale, reflexes, clonus, active range of motion at hip abduction and ankle dorsiflexion, TUG, and step length showed significant differences between the assessments conducted before and during ITB trials. Conversely, active range of motion in most joints, the manual muscle test, and the 10-Meter Walk Test did not show significant differences. The total score of the Berg Balance Scale did not show significant differences, whereas only the item of placing alternate foot on stool was significantly different.Spasticity assessments, including the Modified Ashworth Scale and reflexes, and mobility assessments such as TUG and step length, were useful for detecting the effectiveness of ITB screening for spastic paraparesis. The TUG may be particularly suitable for detecting effects, as it is a quantitative and reliable measure that reflects actual movement in daily living activities.
rights: Copyright © 2024 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.
has PII: S1094-7159(24)01267-4
doi: 10.1016/j.neurom.2024.12.001
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Kuroiwa R
      type: Person
      first name: Ryota
      last name: Kuroiwa
      member of: Department of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: pseudoarthrosis7@chiba-u.jp.
  slot:
    index: 2
    item: Shibuya K
      type: Person
      first name: Kazumoto
      last name: Shibuya
      member of: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  slot:
    index: 3
    item: Nara T
      type: Person
      first name: Takeru
      last name: Nara
      member of: Department of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  slot:
    index: 4
    item: Sakamoto K
      type: Person
      first name: Kazunori
      last name: Sakamoto
      member of: Department of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  slot:
    index: 5
    item: Higuchi Y
      type: Person
      first name: Yoshinori
      last name: Higuchi
      member of: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  slot:
    index: 6
    item: Murata A
      type: Person
      first name: Atsushi
      last name: Murata
      member of: Department of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan.
  slot:
    index: 7
    item: Kuwabara S
      type: Person
      first name: Satoshi
      last name: Kuwabara
      member of: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
created: 2025-1-8T12:25
date last updated: 2025-01-08
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-8T10:32
e ISSN: 1525-1403
has issn l: 1094-7159
has NLM journal title abbreviation: Neuromodulation
publication name: Neuromodulation : journal of the International Neuromodulation Society
language: eng
has national library of medicine journal id: 9804159
derived from: NLM
has place of publication: United States
source: Neuromodulation. 2025-01-07;():.

Medical Malpractice Litigation Associated With Anesthesia: Result From the Lexis China Claims Database 2013 to 2022.
pmid: 39772373
abstract: This study conducted an analysis of medical malpractice litigation associated with anesthesia from 2013 to 2022, aiming to evaluate incidents of anesthesia-related safety concerns among surgical patients. The use of data derived from medical malpractice claims provided valuable insights into potential risks associated with anesthesia, contributing to the mitigation of medical malpractice and the enhancement of patient safety.A retrospective study.The characteristics of anesthesia-related medical malpractice litigation were analyzed using Lexis China database, including patient demographics, timing of the events, the surgical procedure, anesthesia methods, and anesthetic used, as well as case settlement information, verdict information, and monetary award data.Our analysis revealed a total of 183 instances where injury claims could be attributed to anesthesia. The median age of the participants was 26 years, with a predominant proportion of females (116/183, 63.39%). Most of the complaints were from secondary (74/183, 40.44%) and tertiary (85/183, 46.45%) hospitals. General anesthesia (107/183, 58.47%) accounted for the majority of claims, with the highest rates of cardiorespiratory failure or arrest (20/24, 83.33%) or hypoxic brain damage (38/58, 65.52%), which were the most prevalent causes of patient death or disability, respectively. The greatest potential for medical malpractice lawsuits in surgical procedures was found to be associated with cesarean sections, with a rate of 18.03% (33 out of 183 cases). Propofol (n = 6) and lidocaine (n = 4) were the anesthetics with the highest number of lawsuits.Despite the decreasing trend in medical malpractice litigation related to anesthesia over time, several notable hazards have been identified. These hazards included cardiorespiratory failure or arrest or hypoxic brain damage resulting from general anesthesia, a higher risk of cesarean section, the hazards associated with anesthesia-administered non-operating room, and[cell cut: 2061 characters, first 2000 kept]
rights: Copyright © 2025 The American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
has PII: S1089-9472(24)00476-3
doi: 10.1016/j.jopan.2024.09.015
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Hu N
      type: Person
      first name: Na
      last name: Hu
      member of: Department of Anesthesiology, West China Second Hospital, Sichuan University, Key Laboratory of Birth Deficits and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Renmin Nanlu, Chengdu, China.
  slot:
    index: 2
    item: Huang L
      type: Person
      first name: Lu
      last name: Huang
      member of: Department of Anesthesiology, West China Second Hospital, Sichuan University, Key Laboratory of Birth Deficits and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Renmin Nanlu, Chengdu, China.
  slot:
    index: 3
    item: Chen DX
      type: Person
      first name: Dong Xu
      last name: Chen
      member of: Department of Anesthesiology, West China Second Hospital, Sichuan University, Key Laboratory of Birth Deficits and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Renmin Nanlu, Chengdu, China. Electronic address: scucdx@foxmail.com.
created: 2025-1-8T12:23
date last updated: 2025-01-08
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-8T10:33
e ISSN: 1532-8473
has issn l: 1089-9472
has NLM journal title abbreviation: J Perianesth Nurs
publication name: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
language: eng
has national library of medicine journal id: 9610507
derived from: NLM
has place of publication: United States
source: J Perianesth Nurs. 2025-01-07;():.

Effect of Aromatherapy for Postoperative Pain Management in the Postanesthesia Recovery Room: A Systematic Review.
pmid: 39772374
abstract: To analyze available evidence in the literature on the effect of aromatherapy for the management of postoperative pain in the postanesthesia care unit (PACU).Systematic review according to the Joanna Briggs Institute (JBI) model and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement.The search was carried out in August 2023, using descriptors and keywords, in the Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Literature in Health Sciences, Cochrane Central Register of Controlled Trials, Excerpta Medica Database, PUBMED, Scopus, Virtual Health Library, Google Scholar, CAPES, BDTD, and ProQuest portals of theses and dissertations, with no language restrictions or time limit. The quality of evidence was assessed using the tool JBI's critical appraisal checklist for randomized controlled trials. PROSPERO Registration: CRD42023493421.A total of 2,251 studies were investigated, of which 7 studies were included in this review. All of the studies used the inhalation route to administer aromatherapy. They used essential oils such as lavender, lemon, sweet orange, geranium, clary sage, and damascene rose. Most applied the Visual Analog Scale to assess pain. Six studies showed that aromatherapy was effective in relieving pain in the PACU. Studies also observed a reduction in blood pressure, heart rate, incidence of nausea and vomiting, and a decrease in the necessity of antiemetics.The findings emphasize the promising positive effect of aromatherapy for pain management in postoperative care in the PACU. With proper training, aromatherapy can be considered an adjuvant intervention to be carried out by the nursing team.
rights: Copyright © 2024 The American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.
has PII: S1089-9472(24)00466-0
doi: 10.1016/j.jopan.2024.09.011
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Biachi FB
      type: Person
      first name: Fernanda Baratojo
      last name: Biachi
      member of: School of Nursing, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: fernanda@baratojo.com.br.
  slot:
    index: 2
    item: de Oliveira Faria MF
      type: Person
      first name: Maria Fernanda
      last name: de Oliveira Faria
      member of: School of Nursing, University of Sao Paulo, Sao Paulo, Brazil.
  slot:
    index: 3
    item: Oliveira RA
      type: Person
      first name: Ramon Antonio
      last name: Oliveira
      member of: School of Nursing, University of Sao Paulo, Sao Paulo, Brazil; Medical Surgical Nursing Department, School of Nursing, University of Sao Paulo, Sao Paulo, Brazil.
  slot:
    index: 4
    item: de Brito Poveda V
      type: Person
      first name: Vanessa
      last name: de Brito Poveda
      member of: Medical Surgical Nursing Department, School of Nursing, University of Sao Paulo, Sao Paulo, Brazil; JBI Brazilian Affiliated Center, School of Nursing, University of Sao Paulo, Sao Paulo, Brazil.
  slot:
    index: 5
    item: Rizzo Gnatta J
      type: Person
      first name: Juliana
      last name: Rizzo Gnatta
      member of: Medical Surgical Nursing Department, School of Nursing, University of Sao Paulo, Sao Paulo, Brazil; JBI Brazilian Affiliated Center, School of Nursing, University of Sao Paulo, Sao Paulo, Brazil.
created: 2025-1-8T12:23
date last updated: 2025-01-08
issued: 2025-01-07
dp: 2025 Jan 07
created: 2025-1-8T10:33
e ISSN: 1532-8473
has issn l: 1089-9472
has NLM journal title abbreviation: J Perianesth Nurs
publication name: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
language: eng
has national library of medicine journal id: 9610507
derived from: NLM
has place of publication: United States
source: J Perianesth Nurs. 2025-01-07;():.

Good Practices for Health Technology Assessment Guideline Development: A Report of the Health Technology Assessment International, HTAsiaLink, and ISPOR Special Task Force.
pmid: 39772378
abstract: Health technology assessment (HTA) guidelines are intended to support successful implementation of HTA by enhancing consistency and transparency in concepts, methods, process, and use, thereby enhancing the legitimacy of the decision-making process. This report lays out good practices and practical recommendations for developing or updating HTA guidelines to ensure successful implementation.The task force was established in 2022 and comprised experts and academics from various geographical regions, each with substantial experience in developing HTA guidelines for national health policymaking. Literature reviews and key-informant interviews were conducted to inform these good practices. Stakeholder consultations, open peer reviews, and expert opinions validated the recommendations. A series of teleconferences among task force members was held to iteratively refine the report.The recommendations cover 6 key aspects throughout the guideline development cycle: (1) setting objectives, scope, and principles of the guideline, (2) building a team for a quality guideline, (3) defining a stakeholder engagement plan, (iv) developing content and utilizing available resources, (v) putting in place appropriate institutional arrangements, and (vi) monitoring and evaluating guideline success.This report presents a set of resources and context-appropriate practices for developing or updating HTA guidelines. Across all contexts, the recommendations emphasize transparency, building trust among stakeholders, and fostering a culture of ongoing learning and improvement. The report recommends timing development and revision of guidelines according to the HTA landscape and pace of HTA institutionalization. Because HTA is increasingly used to inform different kinds of decision making in a variety of country contexts, it will be important to continue to monitor lessons learned to ensure the recommendations remain relevant and effective.
rights: Copyright © 2024. Published by Elsevier Inc.
has PII: S1098-3015(24)02848-1
doi: 10.1016/j.jval.2024.09.001
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Botwright S
      type: Person
      first name: Siobhan
      last name: Botwright
      member of: Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Nonthaburi, Thailand; University of Strathclyde, Glasgow, Scotland, UK.
  slot:
    index: 2
    item: Sittimart M
      type: Person
      first name: Manit
      last name: Sittimart
      member of: Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Nonthaburi, Thailand. Electronic address: manit.s@hitap.net.
  slot:
    index: 3
    item: Chavarina KK
      type: Person
      first name: Kinanti Khansa
      last name: Chavarina
      member of: Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Nonthaburi, Thailand.
  slot:
    index: 4
    item: Bayani DB
      type: Person
      first name: Diana Beatriz
      last name: Bayani
      member of: Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  slot:
    index: 5
    item: Merlin T
      type: Person
      first name: Tracy
      last name: Merlin
      member of: Adelaide Health Technology Assessment (AHTA), The University of Adelaide, Adelaide, SA, Australia.
  slot:
    index: 6
    item: Surgey G
      type: Person
      first name: Gavin
      last name: Surgey
      member of: Radboud University Medical Center, Nijmegen, The Netherlands.
  slot:
    index: 7
    item: Suharlim C
      type: Person
      first name: Christian
      last name: Suharlim
      member of: Management Science for Health, MA, USA.
  slot:
    index: 8
    item: Espinoza MA
      type: Person
      first name: Manuel A
      last name: Espinoza
      member of: Pontificia Universidad Católica de Chile, Santiago, Chile.
  slot:
    index: 9
    item: Culyer AJ
      type: Person
      first name: Anthony J
      last name: Culyer
      member of: Center for Health Economics, University of York, York, England, UK.
  slot:
    index: 10
    item: Oortwijn W
      type: Person
      first name: Wija
      last name: Oortwijn
      member of: Radboud University Medical Center, Nijmegen, The Netherlands.
  slot:
    index: 11
    item: Teerawattananon Y
      type: Person
      first name: Yot
      last name: Teerawattananon
      member of: Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Nonthaburi, Thailand; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
created: 2025-1-8T12:24
date last updated: 2025-01-08
issued: 2024-10-22
dp: 2024 Oct 22
created: 2025-1-8T10:33
e ISSN: 1524-4733
has issn l: 1098-3015
has NLM journal title abbreviation: Value Health
publication name: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
language: eng
has national library of medicine journal id: 100883818
derived from: NLM
has place of publication: United States
source: Value Health. 2024-10-22;():.