Framework Convention Alliance: building support for global tobacco control.
pmid: 11420574
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: LeGrand C
      type: Person
      first name: C
      last name: LeGrand
      member of: Heart and Stroke Foundation of Canada, Ottawa, Canada.
created: 2001-6-23T10:00
date last updated: 2025-01-17
issued: 2001-06
dp: 2001 Jun
ISSN: 0828-282X
has issn l: 0828-282X
issue: 6
has NLM journal title abbreviation: Can J Cardiol
publication name: The Canadian journal of cardiology
language: eng
has national library of medicine journal id: 8510280
derived from: NLM
starting page: 647
ending page: 8
has place of publication: England
has primary subject term: D014943
has primary subject term: D006293Q000458
has primary subject term: D007390
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: http://id.nlm.nih.gov/mesh/D000092843
has subject term: D006801
source: Can J Cardiol. 2001-06;17(6):647-8.
volume: 17

Tobacco control in an era of trade liberalisation.
pmid: 11226364
doi: 10.1136/tc.10.1.65
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Bettcher D
      type: Person
      first name: D
      last name: Bettcher
      member of: Framework Convention on Tobacco Control, Tobacco-Free Initiative, World Health Organization, Geneva, Switzerland.
  slot:
    index: 2
    item: Shapiro I
      type: Person
      first name: I
      last name: Shapiro
created: 2001-2-28T10:00
date last updated: 2025-01-17
issued: 2001-03
dp: 2001 Mar
ISSN: 0964-4563
has issn l: 0964-4563
issue: 1
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 65
ending page: 7
has place of publication: England
has primary subject term: D003132
has primary subject term: D006293
has primary subject term: D016540
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: D019460
has subject term: D006801
source: Tob Control. 2001-03;10(1):65-7.
volume: 10

State and federal compliance with the Synar Amendment: federal fiscal year 1998.
pmid: 11343500
abstract: The Synar Amendment requires states and territories to enact a law prohibiting the sale of tobacco to minors and to enforce that law in a manner that could reasonably be expected to decrease the availability of tobacco to minors.To determine if the Department of Health and Human Services (DHHS) and applicant states and territories are complying with the Synar Amendment.Block grant applications from 59 states and territories describing activities during the federal fiscal year 1998.Whether applicants had enacted a tobacco sales law without loopholes, conducted enforcement inspections, penalized violators, and conducted a valid statewide survey with violation rates below the permissible threshold, and whether DHHS actions were consistent with the statutory requirements of the Synar Amendment.Three applicants had laws containing loopholes, 6 failed to conduct enforcement inspections, 7 failed to prosecute violators, 2 failed to conduct a valid survey, and 10 failed to demonstrate compliance with violation rate goals. Fifteen applicants failed 1 or more criteria and 8 were ultimately penalized by DHHS. No measurable progress in reducing violation rates was reported by 30 states, with 16 reporting an increase during the previous year. Twenty-four applicants were granted delays.States that demonstrated remarkable progress were balanced by states with worsening performance; as a whole there was no significant national progress toward reducing the availability of tobacco to youths. This failure can be attributed to inadequate resources devoted to enforcement and reliance on merchant education in lieu of bona fide law enforcement.
has PII: poa00442
doi: 10.1001/archpedi.155.5.572
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: DiFranza JR
      type: Person
      first name: J R
      last name: DiFranza
      member of: Department of Family Medicine and Community Health, 55 Lake Ave, University of Massachusetts Medical School, Worcester, MA 01655, USA.
created: 2001-5-18T10:00
date last updated: 2025-01-17
issued: 2001-05
dp: 2001 May
ISSN: 1072-4710
has issn l: 1072-4710
issue: 5
has NLM journal title abbreviation: Arch Pediatr Adolesc Med
publication name: Archives of pediatrics & adolescent medicine
language: eng
has national library of medicine journal id: 9422751
derived from: NLM
starting page: 572
ending page: 8
has place of publication: United States
has primary subject term: D003132Q000331Q000706
has primary subject term: D004335Q000331
has primary subject term: D012907Q000191Q000331
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D000293
has subject term: D006801
has subject term: D000367
has subject term: D015397
has subject term: D012926
has subject term: D014481
source: Arch Pediatr Adolesc Med. 2001-05;155(5):572-8.
volume: 155

Tobacco and cancer.
pmid: 11201674
doi: 10.1097/00008469-200012000-00001
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Hill MJ
      type: Person
      first name: M J
      last name: Hill
created: 2001-2-24T12:00
date last updated: 2025-01-17
issued: 2000-12
dp: 2000 Dec
ISSN: 0959-8278
has issn l: 0959-8278
issue: 6
has NLM journal title abbreviation: Eur J Cancer Prev
publication name: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
language: eng
has national library of medicine journal id: 9300837
derived from: NLM
starting page: 379
ending page: 80
has place of publication: England
has primary subject term: D008175Q000209Q000401
has primary subject term: D012907Q000009
has subject term: D000328
has subject term: D000368
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D012306
source: Eur J Cancer Prev. 2000-12;9(6):379-80.
volume: 9

Tobacco, the Food and Drug Administration, and Congress.
pmid: 11114322
doi: 10.1056/NEJM200012143432411
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Glantz LH
      type: Person
      first name: L H
      last name: Glantz
      member of: Boston University School of Public Health, MA 02118, USA.
  slot:
    index: 2
    item: Annas GJ
      type: Person
      first name: G J
      last name: Annas
created: 2000-12-15T11:00
date last updated: 2025-01-17
issued: 2000-12-14
dp: 2000 Dec 14
ISSN: 0028-4793
has issn l: 0028-4793
issue: 24
has NLM journal title abbreviation: N Engl J Med
publication name: The New England journal of medicine
language: eng
has national library of medicine journal id: 0255562
derived from: NLM
starting page: 1802
ending page: 6
has place of publication: United States
has primary subject term: D012907Q000331
has primary subject term: D019460Q000331Q000592
has primary subject term: D014486Q000331Q000458
has subject term: D006801
has subject term: D006076
has subject term: D006077Q000458
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D014481
source: N Engl J Med. 2000-12-14;343(24):1802-6.
volume: 343

Exposure of adolescent girls to cigar images in women's magazines, 1992-1998.
pmid: 11211640
abstract: This study assessed the exposure of adolescent girls to cigar images in women's magazines from 1992 to 1998.Data were obtained from the 5 women's magazines with the highest readership of adolescent girls.We found a significant upward trend in cigar images portrayed in women's magazines and a significant increase in the portrayal of women cigar smokers over the period observed. Cigar images were less likely than cigarette images to promote tobacco or nontobacco products. Among advertisements, nearly all those that featured cigars promoted nontobacco products; advertisements featuring cigarettes overwhelmingly promoted tobacco products.Between 1992 and 1998, adolescent readers of women's magazines were increasingly exposed to images of cigars.
doi: 10.2105/ajph.91.2.286
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Feit MN
      type: Person
      first name: M N
      last name: Feit
      member of: Mailman School of Public Health, Columbia University, New York, NY, USA. monicafeit@yahoo.com
created: 2001-2-24T12:00
date last updated: 2025-01-17
issued: 2001-02
dp: 2001 Feb
ISSN: 0090-0036
has issn l: 0090-0036
issue: 2
has NLM journal title abbreviation: Am J Public Health
publication name: American journal of public health
language: eng
has national library of medicine journal id: 1254074
derived from: NLM
starting page: 286
ending page: 8
has place of publication: United States
has primary subject term: D000329Q000706Q000639
has primary subject term: D008402Q000706Q000639
has primary subject term: D010506Q000706Q000639
has primary subject term: D000297
has primary subject term: D012907Q000208Q000523
has subject term: D000293
has subject term: D005260
has subject term: D006801
has subject term: D001294
has subject term: D009935Q000706Q000639
has subject term: D015980
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D012922
has subject term: D062789
has subject term: D014481
has subject term: D016387
source: Am J Public Health. 2001-02;91(2):286-8.
volume: 91

Tobacco and laryngeal pathology.
pmid: 11257828
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Garnett JD
      type: Person
      first name: J D
      last name: Garnett
      member of: West Virginia University Voice and Swallowing Center, Morgantown, USA.
created: 2001-3-22T10:00
date last updated: 2025-01-17
ISSN: 0043-3284
has issn l: 0043-3284
issue: 1
has NLM journal title abbreviation: W V Med J
publication name: The West Virginia medical journal
language: eng
has national library of medicine journal id: 0413777
derived from: NLM
starting page: 13
ending page: 6
has place of publication: United States
has primary subject term: D007818Q000209Q000401Q000628
has primary subject term: D007822Q000209Q000401Q000628
has primary subject term: D014832Q000209Q000401Q000628
has subject term: D006801
has subject term: D012307
has subject term: D012907Q000009
has subject term: D015996
has subject term: D014903Q000453
source: W V Med J. ;97(1):13-6.
volume: 97

The cigar revival and the popular press: a content analysis, 1987-1997.
pmid: 11211641
abstract: The purpose of this study was to examine print media coverage of cigars during the period 1987 to 1997.A content analysis of 790 cigar-focused newspaper and magazine articles was conducted.Cigar-focused articles increased substantially over the study period, paralleling increased cigar consumption. Articles focused on cigar business (39%) and events (19%). Only 4% of articles focused on health effects. Sixty-two percent portrayed cigars favorably. The tobacco industry was mentioned in 54% of articles and portrayed positively in 78%. Forty-two percent of the individuals quoted or described in articles were affiliated with the tobacco industry; only 5% were government/public health figures.Print coverage of cigars failed to communicate health risk messages and contributed to positive images of cigars.
doi: 10.2105/ajph.91.2.288
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wenger L
      type: Person
      first name: L
      last name: Wenger
      member of: Institute for Health Policy Studies, School of Medicine, Box 0936, University of California, San Francisco, CA 94143, USA. lynndee@itsa.ucsf.edu
  slot:
    index: 2
    item: Malone R
      type: Person
      first name: R
      last name: Malone
  slot:
    index: 3
    item: Bero L
      type: Person
      first name: L
      last name: Bero
created: 2001-2-24T12:00
date last updated: 2025-01-17
issued: 2001-02
dp: 2001 Feb
ISSN: 0090-0036
has issn l: 0090-0036
issue: 2
has NLM journal title abbreviation: Am J Public Health
publication name: American journal of public health
language: eng
has national library of medicine journal id: 1254074
derived from: NLM
starting page: 288
ending page: 91
has place of publication: United States
has primary subject term: D000329Q000706Q000639
has primary subject term: D008402Q000706Q000639
has primary subject term: D009524Q000706Q000639
has primary subject term: D010506Q000706Q000639
has primary subject term: D012907Q000009Q000523
has subject term: D006801
has subject term: D001294
has subject term: D007722
has subject term: D012919
has subject term: D012938
has subject term: D019460Q000706Q000639
has subject term: D014481
source: Am J Public Health. 2001-02;91(2):288-91.
volume: 91

Tobacco, nicotine, and human cognition.
pmid: 11906678
doi: 10.1080/14622200110101955
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Heishman SJ
      type: Person
      first name: Stephen J
      last name: Heishman
  slot:
    index: 2
    item: Henningfield JE
      type: Person
      first name: Jack E
      last name: Henningfield
  slot:
    index: 3
    item: Singleton EG
      type: Person
      first name: Edward G
      last name: Singleton
created: 2002-3-22T10:00
date last updated: 2025-01-17
issued: 2002-02
dp: 2002 Feb
ISSN: 1462-2203
has issn l: 1462-2203
issue: 1
has NLM journal title abbreviation: Nicotine Tob Res
publication name: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
language: eng
has national library of medicine journal id: 9815751
derived from: NLM
starting page: 3
ending page: 4
has place of publication: England
has primary subject term: D003071
has primary subject term: D009538
has subject term: D015986
has subject term: D006801
source: Nicotine Tob Res. 2002-02;4(1):3-4.
volume: 4

Tobacco availability and point of sale marketing in demographically contrasting districts of Massachusetts.
pmid: 12034986
abstract: To assess the prevalence and characteristics of tobacco sales and point-of-sale promotions and advertising in predominantly Latino business districts, and in comparison districts; and the economic importance of tobacco sales and marketing to Latino owned small businesses.Observational surveys of retail establishments and interviews with store managers.Demographically contrasting business districts of eastern Massachusetts.Percentage of businesses selling tobacco, numbers and characteristics of exterior and interior tobacco advertisements per store, merchant reports of promotional allowances received from tobacco distributors.The proportion of businesses selling tobacco, and hence having storefront tobacco advertising, is strongly negatively correlated with per capita income in the census tracts where businesses are located (Spearman's rho = -0.794, p = 0.006). Mentholated brands are marketed disproportionately in low income, urban communities. Latino merchants are highly dependent on tobacco sales, but would require relatively modest compensation to forego tobacco promotional allowances.Storefront tobacco advertising is far more prevalent in predominantly minority, low income communities than in non-minority, higher income communities, principally because of the differing mix of kinds of businesses in the two types of communities, and the greater prevalence of tobacco vendors in lower income neighbourhoods. Tobacco companies obtain this advertising at little cost.
doi: 10.1136/tc.11.suppl_2.ii71
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Laws MB
      type: Person
      first name: M Barton
      last name: Laws
      member of: The Center for Research on Culture and Health, Latin American Health Institute, 95 Berkeley Street, Boston, MA 02116, USA. Bart@lhi.org
  slot:
    index: 2
    item: Whitman J
      type: Person
      first name: J
      last name: Whitman
  slot:
    index: 3
    item: Bowser DM
      type: Person
      first name: D M
      last name: Bowser
  slot:
    index: 4
    item: Krech L
      type: Person
      first name: L
      last name: Krech
created: 2002-5-30T10:00
date last updated: 2025-01-17
issued: 2002-06
dp: 2002 Jun
ISSN: 0964-4563
has issn l: 0964-4563
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: ii71
ending page: 3
has place of publication: England
has primary subject term: D000329Q000191
has subject term: D003710
has subject term: D006801
has subject term: D008404
has subject term: D019460Q000191
source: Tob Control. 2002-06;11 Suppl 2():ii71-3.
volume: 11 Suppl 2

Public support of tobacco taxation.
pmid: 12362200
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Wilson N
      type: Person
      first name: Nick
      last name: Wilson
  slot:
    index: 2
    item: Thomson G
      type: Person
      first name: George
      last name: Thomson
created: 2002-10-4T04:00
date last updated: 2025-01-17
issued: 2002-07-02
dp: 2002 Jul 02
e ISSN: 1175-8716
has issn l: 0028-8446
issue: 1157
has NLM journal title abbreviation: N Z Med J
publication name: The New Zealand medical journal
language: eng
has national library of medicine journal id: 0401067
derived from: NLM
pg: U73
has place of publication: New Zealand
has primary subject term: D011639
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: D013660Q000331
has primary subject term: D019460Q000331
has subject term: D000329Q000331
has subject term: D006801
has subject term: D009520
has subject term: D016540Q000331
source: N Z Med J. 2002-07-02;115(1157):U73.
volume: 115

The FDA's enforcement of age restrictions on the sale of cigarettes and smokeless tobacco.
pmid: 11338081
abstract: The nation's largest tobacco age-restriction enforcement program is described. Between 1997 and 2000, the U.S. Food and Drug Administration--working with state agencies--conducted nearly 200,000 compliance checks in 123,000 establishments in 44 states, 1 territory, and Washington, D.C. The overall violation rate was 26 percent (more than 40,000 violations), ranging from 9 percent in Maine to 54 percent in the Virgin Islands. Due to the recent Supreme Court ruling, the FDA has stopped conducting these checks and is shutting down its tobacco program. The protocol described in this article will prove useful to others conducting compliance checks and seeking to keep tobacco out of the hands of children.
doi: 10.1097/00124784-200107030-00004
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Natanblut SL
      type: Person
      first name: S L
      last name: Natanblut
      member of: American Legacy Foundation, Washington, DC, USA.
  slot:
    index: 2
    item: Mital M
      type: Person
      first name: M
      last name: Mital
  slot:
    index: 3
    item: Zeller MR
      type: Person
      first name: M R
      last name: Zeller
created: 2001-5-8T10:00
date last updated: 2025-01-17
issued: 2001-05
dp: 2001 May
ISSN: 1078-4659
has issn l: 1078-4659
issue: 3
has NLM journal title abbreviation: J Public Health Manag Pract
publication name: Journal of public health management and practice : JPHMP
language: eng
has national library of medicine journal id: 9505213
derived from: NLM
starting page: 1
ending page: 10
has place of publication: United States
has primary subject term: D003132Q000331Q000592
has primary subject term: D004335
has primary subject term: D014486
has subject term: D000293
has subject term: D002648
has subject term: D006801
has subject term: D000367
has subject term: D019983
has subject term: D014481
source: J Public Health Manag Pract. 2001-05;7(3):1-10.
volume: 7

Tobacco: a social menace.
pmid: 12435012
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Damle SG
      type: Person
      first name: S G
      last name: Damle
created: 2002-11-19T04:00
date last updated: 2025-01-17
issued: 2002-06
dp: 2002 Jun
ISSN: 0970-4388
has issn l: 0970-4388
issue: 2
has NLM journal title abbreviation: J Indian Soc Pedod Prev Dent
publication name: Journal of the Indian Society of Pedodontics and Preventive Dentistry
language: eng
has national library of medicine journal id: 8710631
derived from: NLM
pg: v
has place of publication: India
has subject term: D000329
has subject term: D006801
has subject term: D007194
has subject term: D012940
has subject term: D019460
source: J Indian Soc Pedod Prev Dent. 2002-06;20(2):v.
volume: 20

Tobacco carcinogens, their biomarkers and tobacco-induced cancer.
pmid: 14570033
abstract: The devastating link between tobacco products and human cancers results from a powerful alliance of two factors - nicotine and carcinogens. Without either one of these, tobacco would be just another commodity, instead of being the single greatest cause of death due to preventable cancer. Nicotine is addictive and toxic, but it is not carcinogenic. This addiction, however, causes people to use tobacco products continually, and these products contain many carcinogens. What are the mechanisms by which this deadly combination leads to 30% of cancer-related deaths in developed countries, and how can carcinogen biomarkers help to reveal these mechanisms?
doi: 10.1038/nrc1190
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Hecht SS
      type: Person
      first name: Stephen S
      last name: Hecht
      member of: University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu
created: 2003-10-23T05:00
date last updated: 2025-01-17
issued: 2003-10
dp: 2003 Oct
ISSN: 1474-175X
has issn l: 1474-175X
issue: 10
has NLM journal title abbreviation: Nat Rev Cancer
publication name: Nature reviews. Cancer
language: eng
has national library of medicine journal id: 101124168
derived from: NLM
starting page: 733
ending page: 44
has place of publication: England
has primary subject term: D014408Q000032
has primary subject term: D002273Q000493
has primary subject term: D009369Q000139Q000175Q000378
has subject term: D006801
has subject term: D009538
source: Nat Rev Cancer. 2003-10;3(10):733-44.
volume: 3

Prognostic impact of Ets-1 overexpression in betel and tobacco related oral cancer.
pmid: 11718456
abstract: In oral squamous cell carcinoma (SCC), the presence of lymph node metastasis is one of the most important prognostic factors, correlating locoregional spread, recurrence, distant metastasis and survival. However, the biological factors implicated and the mechanisms underlying these events are not completely elucidated. We reported Ets-1 expression in oral SCC and proposed that it may serve as a plausible marker of invasive potential and lymph node metastasis. Herein, we investigate the prognostic significance of Ets-1 expression in oral cancer. One hundred oral SCCs assessed for Ets-1 expression showed significant association with tumor stage (P = .027), lymph node involvement (P < 10(-6)) and distant organ metastasis (P = .007). The transcription factor Ets-1 regulates the expression of several genes involved in extracellular matrix remodeling that may account for its association with lymph node and distant organ metastasis. Kaplan-Meier survival analysis entailed significant association of Ets-1 expression in oral SCCs with reduced disease free survival (P = .0041), suggesting its utility as a prognosticator for oral cancer. In conclusion, these findings underscore the role of Ets-1 in oral tumor invasion and metastasis and may thus account for its association with diminished disease free survival.
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Pande P
      type: Person
      first name: P
      last name: Pande
      member of: Department of Biochemistry, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi.
  slot:
    index: 2
    item: Soni S
      type: Person
      first name: S
      last name: Soni
  slot:
    index: 3
    item: Chakravarti N
      type: Person
      first name: N
      last name: Chakravarti
  slot:
    index: 4
    item: Mathur M
      type: Person
      first name: M
      last name: Mathur
  slot:
    index: 5
    item: Shukla NK
      type: Person
      first name: N K
      last name: Shukla
  slot:
    index: 6
    item: Ralhan R
      type: Person
      first name: R
      last name: Ralhan
created: 2001-11-23T10:00
date last updated: 2025-01-17
issued: 2001
dp: 2001
ISSN: 0361-090X
has issn l: 0361-090X
issue: 5
has NLM journal title abbreviation: Cancer Detect Prev
publication name: Cancer detection and prevention
language: eng
has national library of medicine journal id: 7704778
derived from: NLM
starting page: 496
ending page: 501
has place of publication: England
has primary subject term: D001114Q000009
has primary subject term: D014408Q000378
has primary subject term: D002294Q000209Q000378Q000473
has primary subject term: D009062Q000209Q000378Q000473
has primary subject term: D011518Q000378
has primary subject term: D014157Q000378
has subject term: D018572
has subject term: D005260
has subject term: D005500
has subject term: D006801
has subject term: D007124
has subject term: D008207
has subject term: D008297
has subject term: D008875
has subject term: D009367
has subject term: D011379
has subject term: D011505Q000378
has subject term: D050784
has subject term: D050783
source: Cancer Detect Prev. 2001;25(5):496-501.
volume: 25

Tobacco & taxes.
pmid: 11257840
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Foster DS
      type: Person
      first name: D S
      last name: Foster
created: 2001-3-22T10:00
date last updated: 2025-01-17
ISSN: 0043-3284
has issn l: 0043-3284
issue: 1
has NLM journal title abbreviation: W V Med J
publication name: The West Virginia medical journal
language: eng
has national library of medicine journal id: 0413777
derived from: NLM
starting page: 53
ending page: 4
has place of publication: United States
has primary subject term: D012907Q000191
has primary subject term: D013660Q000331
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D019460Q000191
has subject term: D014903
source: W V Med J. ;97(1):53-4.
volume: 97

Why we need an international agreement on tobacco control.
pmid: 11211624
doi: 10.2105/ajph.91.2.191
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Satcher D
      type: Person
      first name: D
      last name: Satcher
created: 2001-2-24T12:00
date last updated: 2025-01-17
issued: 2001-02
dp: 2001 Feb
ISSN: 0090-0036
has issn l: 0090-0036
issue: 2
has NLM journal title abbreviation: Am J Public Health
publication name: American journal of public health
language: eng
has national library of medicine journal id: 1254074
derived from: NLM
starting page: 191
ending page: 3
has place of publication: United States
has primary subject term: D004335Q000458
has primary subject term: D014943
has primary subject term: D007391
has primary subject term: D012907Q000009Q000453
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D006801
has subject term: D000329
has subject term: D019049
has subject term: D003906
has subject term: D020380
has subject term: D011159
has subject term: D019460
has subject term: D014481Q000453
source: Am J Public Health. 2001-02;91(2):191-3.
volume: 91

Measuring statewide merchant compliance with tobacco minimum age laws: the Massachusetts experience.
pmid: 11441743
abstract: This study evaluated merchant compliance with laws prohibiting the sale of tobacco to minors in Massachusetts.Stratified cluster sampling was used to select outlets from which youths aged 13 to 17 years attempted to purchase tobacco.Illegal sales were more common when the youth purchasing the tobacco was older, when the clerk was male, and when tobacco was obtained from a self-service display or unlocked vending machine. Failure to request proof of age was the strongest predictor of illegal sales.Measured compliance rates are strongly influenced by the age of the youths used to purchase tobacco.
doi: 10.2105/ajph.91.7.1124
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: DiFranza JR
      type: Person
      first name: J R
      last name: DiFranza
      member of: Department of Family Medicine and Community Health, University of Massachusetts Medical Center, Worcester, MA 01655, USA. difranzj@ummhc.org
  slot:
    index: 2
    item: Celebucki CC
      type: Person
      first name: C C
      last name: Celebucki
  slot:
    index: 3
    item: Mowery PD
      type: Person
      first name: P D
      last name: Mowery
created: 2001-7-10T10:00
date last updated: 2025-01-17
issued: 2001-07
dp: 2001 Jul
ISSN: 0090-0036
has issn l: 0090-0036
issue: 7
has NLM journal title abbreviation: Am J Public Health
publication name: American journal of public health
language: eng
has national library of medicine journal id: 1254074
derived from: NLM
starting page: 1124
ending page: 5
has place of publication: United States
has primary subject term: D003132Q000331Q000706
has primary subject term: D008389Q000331Q000706
has subject term: D000293
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D000367
has subject term: D016009
has subject term: D016000
has subject term: D016015
has subject term: D008404
has subject term: D011237
has subject term: D012737
has subject term: D012907Q000331
has subject term: http://id.nlm.nih.gov/mesh/D000074606
source: Am J Public Health. 2001-07;91(7):1124-5.
volume: 91

http://rdf.ncbi.nlm.nih.gov/pubmed/12035008
pmid: 12035008
abstract: This report summarises a workshop on evaluation of tobacco control interventions convened in Santa Fe, New Mexico in June 2001 by the Institute for Global Tobacco Control at the Johns Hopkins Bloomberg School of Public Health. The evaluation of such interventions is filled with complexities which intensify as the scope of tobacco control programmes increase. Evaluators are charged with the task of determining the effect of interventions in terms of magnitude of change, the relative contribution of programme components, and the relative impact for different populations. The report explores the theoretical foundations of tobacco control evaluation and provides a conceptual framework for capturing elements necessary for evaluating interventions. It then provides two case studies of challenges encountered when evaluating large scale tobacco control initiatives. The report summarises the discussions and recommendations of the workshop's three working groups. Participants were certain and unanimous that the current state of evaluation research must be improved to evaluate accurately the dynamic nature of comprehensive tobacco control programmes. Hierarchical or multilevel modelling approaches were seen as promising for further research. Coordinated evaluation will provide a better understanding of local, state, and national tobacco control efforts.
doi: 10.1136/tc.11.2.140
created: 2002-5-30T10:00
date last updated: 2025-01-17
issued: 2002-06
dp: 2002 Jun
ISSN: 0964-4563
has issn l: 0964-4563
issue: 2
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 140
ending page: 5
has place of publication: England
has primary subject term: D017408
has primary subject term: D006293
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D006801
has subject term: D019460
source: Tob Control. 2002-06;11(2):140-5.
title: Evaluating comprehensive tobacco control interventions: challenges and recommendations for future action. Report of a workshop convened by the Institute for Global Tobacco Control, Johns Hopkins Bloomberg School of Public Health.
volume: 11

Oral cancers in India.
pmid: 11301379
abstract: Oral cancers in India constitute a major portion of all cancers. With a population of 1,000 million, this cancer poses many challenges. More than 90% of cases are tobacco-related, and hence eminently amenable to primary prevention. The progress made in these cancers is helping us to address the problem in a better way, bringing hope to overcome the misery. Semin Oncol 28:169-173.
rights: Copyright 2001 by W.B. Saunders Company.
has PII: S0093775401000483
doi: 10.1016/s0093-7754(01)90088-0
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Babu KG
      type: Person
      first name: K G
      last name: Babu
      member of: Kidwai Memorial Institute of Oncology, Bangalore, India.
created: 2001-4-13T10:00
date last updated: 2025-01-17
issued: 2001-04
dp: 2001 Apr
ISSN: 0093-7754
has issn l: 0093-7754
issue: 2
has NLM journal title abbreviation: Semin Oncol
publication name: Seminars in oncology
language: eng
has national library of medicine journal id: 0420432
derived from: NLM
starting page: 169
ending page: 73
has place of publication: United States
has primary subject term: D003906
has primary subject term: D009062Q000453Q000209Q000517Q000628
has subject term: D006801
has subject term: D017281
has subject term: D007194Q000453
has subject term: D012307
has subject term: D012907Q000009Q000453
source: Semin Oncol. 2001-04;28(2):169-73.
volume: 28

Safety of children in grocery carts: adults' personal health and safety habits.
pmid: 12841465
abstract: Observations of 246 children and the adults accompanying them were carried out in supermarkets. Of those arriving and leaving by automobile (n = 194), 36% of adults used safety belts, and 51.1% of children used safety belts or restraining seats. While shopping, 79% of adults lost sight of the children in their care at least once, and 73.2% were 10 feet or more from their children at least once. 48% of children climbed or attempted to climb from carts; 27% stood in carts, and 23.6% handled hazardous products. 24% of adults purchased tobacco products. Poor adult supervision of children was related to adult's nonuse of safety belts and the child's and adult's ages. Climbing from the cart was related in a logistic regression to both poor adult supervision and child's age. Tobacco purchases were related to handling of hazards by children and standing in carts. Child's age and adult's safety belt use related to the restraint of children in vehicles.
doi: 10.2466/pr0.2003.92.3.908
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Harrell WA
      type: Person
      first name: W Andrew
      last name: Harrell
      member of: University of Alberta, Centre for Experimental Sociology, Edmonton, Canada. aharrell@gpu.srv.ualberta.ca
created: 2003-7-5T05:00
date last updated: 2025-01-17
issued: 2003-06
dp: 2003 Jun
ISSN: 0033-2941
has issn l: 0033-2941
issue: 3 Pt 1
has NLM journal title abbreviation: Psychol Rep
publication name: Psychological reports
language: eng
has national library of medicine journal id: 0376475
derived from: NLM
starting page: 908
ending page: 14
has place of publication: United States
has primary subject term: D000058Q000517
has primary subject term: D015438
has primary subject term: D016487Q000523
has primary subject term: D012449
has primary subject term: D012931
has subject term: D000328
has subject term: D000416
has subject term: D002648
has subject term: D002675
has subject term: D015386Q000009
has subject term: D006801
has subject term: D007223
has subject term: D012309
has subject term: D012622
source: Psychol Rep. 2003-06;92(3 Pt 1):908-14.
volume: 92

Social drug use in the parturient: implications for the management of obstetrical anaesthesia.
pmid: 14556345
abstract: Maternal use of social drugs in pregnancy continues to increase--worldwide. Although a great deal has been learned regarding the implications of illicit drug abuse in pregnancy (cocaine, amphetamines, hallucinogens), the use of social drug in pregnancy has received far less attention. This article reviews the consequences of the social drug use in pregnancy including ethanol, tobacco and caffeine and offers recommendation for anaesthetic management of these potentially complicated pregnancies.
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kuczkowski KM
      type: Person
      first name: K M
      last name: Kuczkowski
      member of: Departments of Anaesthesiology and Reproductive Medicine, University of California San Diego, San Diego, California, USA.
created: 2003-10-15T05:00
date last updated: 2025-01-17
issued: 2003-03
dp: 2003 Mar
ISSN: 0300-5283
has issn l: 0300-5283
issue: 1
has NLM journal title abbreviation: Med J Malaysia
publication name: The Medical journal of Malaysia
language: eng
has national library of medicine journal id: 0361547
derived from: NLM
pg: 147-54; quiz 155
has place of publication: Malaysia
has primary subject term: D000773Q000009
has primary subject term: D002110Q000009
has primary subject term: D002492Q000009
has primary subject term: D000697Q000009
has primary subject term: D000431Q000009
has primary subject term: D007744Q000139
has primary subject term: D011248Q000139
has subject term: D005260
has subject term: D006801
has subject term: D011247
has subject term: D019966
source: Med J Malaysia. 2003-03;58(1):147-54; quiz 155.
volume: 58

[Tobacco pneumoconiosis ].
pmid: 14761488
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Wang BS
      type: Person
      first name: Bin-sen
      last name: Wang
  slot:
    index: 2
    item: Wang Y
      type: Person
      first name: Yun
      last name: Wang
created: 2004-2-6T05:00
date last updated: 2025-01-17
issued: 2003-06
dp: 2003 Jun
ISSN: 1001-9391
has issn l: 1001-9391
issue: 3
has NLM journal title abbreviation: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
publication name: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
language: chi
has national library of medicine journal id: 8410840
derived from: NLM
pg: 202
has place of publication: China
has primary subject term: D016273Q000009
has primary subject term: D011009Q000175Q000209
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D019460
source: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003-06;21(3):202.
volume: 21

A gadget can't fix what's wrong with the tobacco distribution system.
pmid: 15015860
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: DiFranza JR
      type: Person
      first name: Joseph R
      last name: DiFranza
      member of: University of Massachusetts Medical School, Worcester 01655, USA. difranza@banyan.ummed.edu
created: 2004-3-16T05:00
date last updated: 2025-01-17
issued: 2003
dp: 2003
ISSN: 0197-5897
has issn l: 0197-5897
issue: 3-4
has NLM journal title abbreviation: J Public Health Policy
publication name: Journal of public health policy
language: eng
has national library of medicine journal id: 8006508
derived from: NLM
starting page: 269
ending page: 73
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: D019460Q000458
has subject term: D000293
has subject term: D006801
has subject term: D011634
has subject term: D014481
source: J Public Health Policy. 2003;24(3-4):269-73.
volume: 24

Liquid chromatographic/tandem mass spectrometric method for the determination of the tobacco-specific nitrosamine metabolite NNAL in smokers' urine.
pmid: 12526011
abstract: A specific and rapid liquid chromatographic/tandem mass spectrometric (LC/MS/MS) method was developed and validated for NNAL, a metabolite of the tobacco-specific nitrosamine metabolite NNK. The metabolite was detected in smokers' urine with a limit of quantitation (LOQ) of 20 pg ml(-1) and a linear range up to 1000 pg ml(-1). The method features a single solid-phase extraction step and MS/MS monitoring following electrospray ionization. Fragmentation pathways for the protonated molecular ion are proposed. The sample preparation is simpler than that for gas chromatographic methods reported in the literature and maintains sensitivity adequate for determining NNAL in smokers' urine. By using enzyme hydrolysis to determine total NNAL in urine, the amount of NNAL-glucuronide was calculated. A standard pooled smokers' urine sample used for development gave values of 176 +/- 8 pg ml(-1) free NNAL and 675 +/- 26 pg ml(-1) total NNAL following enzyme hydrolysis. The method was applied to a group of seven smokers; the free NNAL level for the group was 101-256 pg ml(-1) with NNAL-glucuronides at 247-566 pg ml(-1). The ratio of conjugated to free NNAL was in the range 0.98-2.95. The variability in total daily amount of NNAL excreted (ng per 24 h) had RSDs of 6-21% for free NNAL, 7-22% for conjugated NNAL and 6-20% for total NNAL excreted. When normalized to the number of cigarettes smoked, the amounts of NNAL excreted per cigarette smoked were in the range of amounts of NNK yields reported for cigarettes in the literature.
rights: Copyright 2003 John Wiley & Sons, Ltd.
doi: 10.1002/jms.406
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Byrd GD
      type: Person
      first name: Gary D
      last name: Byrd
      member of: R. J. Reynolds Tobacco Company, Biological Chemistry Division, Winston-Salem, North Carolina 27102, USA. byrdg@rjrt.com
  slot:
    index: 2
    item: Ogden MW
      type: Person
      first name: Michael W
      last name: Ogden
created: 2003-1-15T04:00
date last updated: 2025-01-17
issued: 2003-01
dp: 2003 Jan
ISSN: 1076-5174
has issn l: 1076-5174
issue: 1
has NLM journal title abbreviation: J Mass Spectrom
publication name: Journal of mass spectrometry : JMS
language: eng
has national library of medicine journal id: 9504818
derived from: NLM
starting page: 98
ending page: 107
has place of publication: England
has primary subject term: D013058Q000379
has primary subject term: D009602Q000302Q000378Q000652
has primary subject term: D012907Q000652
has subject term: D000328
has subject term: D001711
has subject term: D002851
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D015394
has subject term: D012680
has subject term: D012996Q000737
source: J Mass Spectrom. 2003-01;38(1):98-107.
volume: 38

Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.
pmid: 15184256
abstract: Vegetable consumption, including cruciferous vegetables, is protective against lung cancer, but the mechanisms are poorly understood. The purpose of this study was to investigate the effects of cruciferous vegetable consumption on the metabolism of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers. The study was carried out in Singapore Chinese, whose mean daily intake of cruciferous vegetables is three times greater than that of people in the United States. Eighty-four smokers provided urine samples and were interviewed about dietary habits using a structured questionnaire, which included questions on consumption of nine commonly consumed cruciferous vegetables. Samples of these vegetables obtained in Singapore markets at three different times of year were analyzed for glucosinolates. Urine was analyzed for metabolites of NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Glucs). Glucobrassicins, which release indole-3-carbinols on chewing, were the major glucosinolates in seven of the nine cruciferous vegetables, accounting for 70.0% to 93.2% of all glucosinolates in these vegetables. There was a significant correlation (P = 0.01) between increased consumption of glucobrassicins and decreased levels of NNAL in urine after adjustment for number of cigarettes smoked per day; similar trends were observed for NNAL-Glucs (P = 0.08) and NNAL plus NNAL-Glucs (P = 0.03). These results are consistent with those of previous studies, which demonstrate that indole-3-carbinol decreases levels of urinary NNAL probably by inducing hepatic metabolism of NNK. The results are discussed with respect to the known chemopreventive activity of indole-3-carbinol against lung tumorigenesis by NNK in mice and the effects of isothiocyanates, which are also formed on consumption of cruciferous vegetables, on NNK metabolism. The results of this study demonstrate the complexities in assessing effects of crucif[cell cut: 2042 characters, first 2000 kept]
has PII: 13/6/997
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Hecht SS
      type: Person
      first name: Stephen S
      last name: Hecht
      member of: University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St. SE, Minneapolis, MN 55455, USA. hecht002@umn.edu
  slot:
    index: 2
    item: Carmella SG
      type: Person
      first name: Steven G
      last name: Carmella
  slot:
    index: 3
    item: Kenney PM
      type: Person
      first name: Patrick M J
      last name: Kenney
  slot:
    index: 4
    item: Low SH
      type: Person
      first name: Siew-Hong
      last name: Low
  slot:
    index: 5
    item: Arakawa K
      type: Person
      first name: Kazuko
      last name: Arakawa
  slot:
    index: 6
    item: Yu MC
      type: Person
      first name: Mimi C
      last name: Yu
created: 2004-6-9T05:00
date last updated: 2025-01-17
issued: 2004-06
dp: 2004 Jun
ISSN: 1055-9965
has issn l: 1055-9965
issue: 6
has NLM journal title abbreviation: Cancer Epidemiol Biomarkers Prev
publication name: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
language: eng
has national library of medicine journal id: 9200608
derived from: NLM
starting page: 997
ending page: 1004
has place of publication: United States
has primary subject term: D002273Q000378
has primary subject term: D005961Q000737Q000652
has primary subject term: D009602Q000652
has primary subject term: D012907Q000652
has primary subject term: D014675Q000737Q000145Q000378
has subject term: D000368
has subject term: D016588Q000652
has subject term: D002681Q000208
has subject term: D005260
has subject term: D020719Q000652
has subject term: D006801
has subject term: D007211
has subject term: D008175Q000517
has subject term: D008297
has subject term: D008875
has subject term: D011446
has subject term: D012846
has subject term: D011795
source: Cancer Epidemiol Biomarkers Prev. 2004-06;13(6):997-1004.
volume: 13

Nurses speak out against the marketing of tobacco.
pmid: 15359180
has PII: 00004045-200409000-00015
doi: 10.1097/00004045-200409000-00015
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Jones P
      type: Person
      first name: Pamela
      last name: Jones
      member of: UCSF School of Nursing, San Francisco, CA 94118, USA. pjones@itsa.ucsf.edu
created: 2004-9-11T05:00
date last updated: 2025-01-17
issued: 2004-09
dp: 2004 Sep
ISSN: 0884-741X
has issn l: 0884-741X
issue: 9
has NLM journal title abbreviation: Home Healthc Nurse
publication name: Home healthcare nurse
language: eng
has national library of medicine journal id: 8403379
derived from: NLM
pg: 652
has place of publication: United States
has primary subject term: D008119
has primary subject term: D024802
has subject term: D002140
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D040541
has subject term: D016540
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D019460
source: Home Healthc Nurse. 2004-09;22(9):652.
volume: 22

[Tobacco and murder--the first case of nicotine poisoning proved in a homicide].
pmid: 12553150
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Permin H
      type: Person
      first name: Henrik
      last name: Permin
  slot:
    index: 2
    item: Wagner P
      type: Person
      first name: Peter
      last name: Wagner
created: 2003-1-30T04:00
date last updated: 2025-01-17
issued: 2002-12-16
dp: 2002 Dec 16
ISSN: 0041-5782
has issn l: 0041-5782
issue: 51
has NLM journal title abbreviation: Ugeskr Laeger
publication name: Ugeskrift for laeger
language: dan
has national library of medicine journal id: 0141730
derived from: NLM
starting page: 6084
ending page: 5
has place of publication: Denmark
has primary subject term: D056246Q000266
has primary subject term: D005554Q000266
has primary subject term: D006708Q000266
has subject term: D001530
has subject term: D049672
has subject term: D006801
has subject term: D009538Q000266Q000506
source: Ugeskr Laeger. 2002-12-16;164(51):6084-5.
volume: 164

Effect of chronic tobacco use on salivary concentrations of sodium and potassium.
pmid: 12870317
abstract: Most of the methods of tobacco are use linked to the oral cavity where the taste receptors, a primary site for stimulation of salivary secretion, are constantly exposed to tobacco. It is generally believed that repeated exposure of a receptor to a stimulus results in inactivation (suppression) of the receptor. The present study was designed to document changes in salivary concentrations of sodium (Na+) and potassium (K+) in response to this effect in chronic tobacco users.Subjects of the study were divided into smokers, pan (tobacco-betel-lime quid) chewers, niswar (moist oral snuff) differs and non tobacco users as controls. The saliva of each subject was collected under resting condition and following application of crude nicotine and citric acid solutions to the tip of his tongue.After stimulation with nicotine all groups exhibited an increase in sodium concentration but the increase was significant (p < 0.05) in pan chewers only. However all groups showed a highly significant (p < 0.005) increase in sodium concentration after citric acid stimulation. No statistically significant (p > 0.05) decrease in potassium concentration was observed in any group after nicotine stimulation but all chronic tobacco user groups showed a highly significant (p < 0.005) decrease after citric acid stimulation.We conclude the sodium concentration increases and that of potassium decreases with the increase in salivary flow rates and this observation in chronic tobacco users was not much different from that in non tobacco users.
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Khan GJ
      type: Person
      first name: Ghulam Jillani
      last name: Khan
      member of: Department of Physiology, Khyber Medical College, Peshawar.
  slot:
    index: 2
    item: Mehmood R
      type: Person
      first name: Rashid
      last name: Mehmood
  slot:
    index: 3
    item: Salah-ud-Din
      type: Person
      last name: Salah-ud-Din
  slot:
    index: 4
    item: Ihtesham-ul-Haq
      type: Person
      last name: Ihtesham-ul-Haq
created: 2003-7-23T05:00
date last updated: 2025-01-17
ISSN: 1025-9589
has issn l: 1025-9589
issue: 1
has NLM journal title abbreviation: J Ayub Med Coll Abbottabad
publication name: Journal of Ayub Medical College, Abbottabad : JAMC
language: eng
has national library of medicine journal id: 8910750
derived from: NLM
starting page: 41
ending page: 4
has place of publication: Pakistan
has primary subject term: D011188Q000378
has primary subject term: D012463Q000378
has primary subject term: D012964Q000378
has subject term: D000328
has subject term: D006801
has subject term: D008297
has subject term: D064424Q000009
has subject term: D009538Q000009
source: J Ayub Med Coll Abbottabad. ;15(1):41-4.
volume: 15

Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposure.
pmid: 12431278
abstract: Head and neck squamous cell carcinomas (HNSCC) have been causally associated with tobacco and alcohol exposure. However, 10-15% of HNSCC develop in absence of significant carcinogen exposure. Several lines of evidence suggest that the genetic composition of HNSCC varies based on the extent of tobacco/alcohol exposure, however, no genome wide measures have been applied to address this issue. We used comparative genomic hybridization (CGH) to screen for the genetic aberrations in 71 patients with head and neck squamous cell carcinoma and stratified the findings by the status of tobacco/alcohol exposure.Although the median number of abnormalities (9), gains (6) and losses (2) per case and the overall pattern of abnormalities did not vary significantly by the extent of tobacco/alcohol exposure, individual abnormalities segregating these patients were identified. Gain of 1p (p = 0.03) and 3q amplification (p = 0.05) was significantly more common in patients with a history of tobacco/alcohol exposure.This data suggests that the overall accumulated chromosomal aberrations in head and neck squamous cell carcinoma are not significantly influenced by the severity of tobacco/alcohol exposure with limited exceptions.
doi: 10.1186/1471-2156-3-22
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Singh B
      type: Person
      first name: Bhuvanesh
      last name: Singh
      member of: Laboratory of Epithelial Cancer Biology, Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, USA. singhb@mskcc.org
  slot:
    index: 2
    item: Wreesmann VB
      type: Person
      first name: Volkert B
      last name: Wreesmann
  slot:
    index: 3
    item: Pfister D
      type: Person
      first name: David
      last name: Pfister
  slot:
    index: 4
    item: Poluri A
      type: Person
      first name: Ashok
      last name: Poluri
  slot:
    index: 5
    item: Shaha AR
      type: Person
      first name: Ashok R
      last name: Shaha
  slot:
    index: 6
    item: Kraus D
      type: Person
      first name: Dennis
      last name: Kraus
  slot:
    index: 7
    item: Shah JP
      type: Person
      first name: Jatin P
      last name: Shah
  slot:
    index: 8
    item: Rao PH
      type: Person
      first name: Pulivarthi H
      last name: Rao
created: 2002-11-15T04:00
date last updated: 2025-01-17
issued: 2002-11-14
dp: 2002 Nov 14
e ISSN: 1471-2156
has issn l: 1471-2156
has NLM journal title abbreviation: BMC Genet
publication name: BMC genetics
language: eng
has national library of medicine journal id: 100966978
derived from: NLM
pg: 22
has place of publication: England
has primary subject term: D002294Q000235Q000378
has primary subject term: D002869Q000187
has primary subject term: D000431Q000009
has primary subject term: D006258Q000235Q000378
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D002872
has subject term: D005260
has subject term: D005784Q000235
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D009693
source: BMC Genet. 2002-11-14;3():22.
volume: 3

[Educating through fear, an anti-tobacco campaign].
pmid: 12564053
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Lecorps P
      type: Person
      first name: P
      last name: Lecorps
      member of: L'Ecole nationale de la santé publique, Rennes.
created: 2003-2-5T04:00
date last updated: 2025-01-17
issued: 2002-09
dp: 2002 Sep
ISSN: 0995-3914
has issn l: 0995-3914
issue: 3
has NLM journal title abbreviation: Sante Publique
publication name: Sante publique (Vandoeuvre-les-Nancy, France)
language: fre
has national library of medicine journal id: 9216153
derived from: NLM
starting page: 285
ending page: 6
has place of publication: France
has primary subject term: D001294
has primary subject term: D005239
has primary subject term: D006266Q000458
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D005602
has subject term: D006801
has subject term: D012907Q000009Q000523
has subject term: D016540
source: Sante Publique. 2002-09;14(3):285-6.
volume: 14

Prenatal cocaine/polydrug exposure and infant performance on an executive functioning task.
pmid: 12850756
abstract: Executive functioning in cocaine/polydrug (marijuana, alcohol, tobacco) exposed infants was assessed in a single session, occurring between 9.5 and 12.5 months of age. In an A-not-B task, infants searched, after performance-adjusted delays, for an object hidden in a new location. Overall, the cocaine-exposed (CE) infants did not differ from non-CE controls recruited from the same at-risk population. However, comparison of heavier-CE (n = 9) to the combined group of lighter-CE (n = 10) and non-CE (n = 32) infants revealed significant differences on A-not-B performance, as well as on global tests of mental and motor development. Covariates investigated included socioeconomic status, marital status, race, maternal age, years of education, weeks of gestation, birth weight, as well as severity of prenatal marijuana, alcohol, and tobacco exposure. The relationship of heavier-CE status to motor development was mediated by length of gestation, and the relationship of heavier-CE status to mental development was confounded with maternal gestational use of cigarettes. The relationship of heavier-CE status to A-not-B performance remained significant after controlling for potentially confounded variables and mediators, but was not statistically significant after controlling for the variance associated with global mental development.
doi: 10.1207/S15326942DN2401_05
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Noland JS
      type: Person
      first name: Julia S
      last name: Noland
      member of: Department of Pediatrics and General Medical Sciences, Case Western Reserve University, USA. jsn4@po.cwru.edu
  slot:
    index: 2
    item: Singer LT
      type: Person
      first name: Lynn T
      last name: Singer
  slot:
    index: 3
    item: Mehta SK
      type: Person
      first name: Sudhir K
      last name: Mehta
  slot:
    index: 4
    item: Super DM
      type: Person
      first name: Dennis M
      last name: Super
created: 2003-7-10T05:00
date last updated: 2025-01-17
issued: 2003
dp: 2003
ISSN: 8756-5641
has issn l: 1532-6942
issue: 1
has NLM journal title abbreviation: Dev Neuropsychol
publication name: Developmental neuropsychology
language: eng
has national library of medicine journal id: 8702038
derived from: NLM
starting page: 499
ending page: 517
has place of publication: England
has primary subject term: D003042Q000009
has primary subject term: D009420Q000187Q000254Q000503
has primary subject term: D011248
has primary subject term: D011297
has primary subject term: D011597Q000187
has primary subject term: D019966Q000150
has subject term: D000428Q000009
has subject term: D002188Q000009
has subject term: D002657
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D011247
source: Dev Neuropsychol. 2003;24(1):499-517.
volume: 24

Middle East aircrew use of alcohol, tobacco, coffee, and medicaments.
pmid: 15828642
abstract: The purpose of this study was to assess the prevalence of the use of alcohol, tobacco, coffee, and various medications among flying crew and clerks working in a ministry in Kuwait.In a cross-sectional study, a self-administered questionnaire was filled in by 277 flying crew and 302 clerks of a comparable age and gender ratio.Frequencies of using alcohol, tobacco, coffee, and various medications were much higher among flying crew as compared to clerks. Flying crew were a very homogenous group in terms of exposure to the substances studied with only two exceptions: younger people were more likely to drink alcohol abroad (but not in Kuwait), and cabin crew relied on herbal medicine more than pilots.Flying crew differ very much from a socially comparable segment of the local population, but it is not possible to discern the impact of occupational risks (jet leg and night shifts) from exposure to foreign influences and, as for alcohol and sedatives, from easier availability.
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Omar MM
      type: Person
      first name: Moanis M
      last name: Omar
      member of: Faculty of Medicine, Health Science Center, Kuwait University, Hawally, Kuwait. monisbasheer@hotmail.com
  slot:
    index: 2
    item: Al-Mulla KF
      type: Person
      first name: Khalid F
      last name: Al-Mulla
  slot:
    index: 3
    item: Al-Seleem TA
      type: Person
      first name: Talal A
      last name: Al-Seleem
  slot:
    index: 4
    item: Murad B
      type: Person
      first name: Bader
      last name: Murad
  slot:
    index: 5
    item: Radovanovic Z
      type: Person
      first name: Zoran
      last name: Radovanovic
created: 2005-4-15T09:00
date last updated: 2025-01-17
issued: 2005-04
dp: 2005 Apr
ISSN: 0095-6562
has issn l: 0095-6562
issue: 4
has NLM journal title abbreviation: Aviat Space Environ Med
publication name: Aviation, space, and environmental medicine
language: eng
has national library of medicine journal id: 7501714
derived from: NLM
starting page: 395
ending page: 8
has place of publication: United States
has primary subject term: D000428
has primary subject term: D001359
has primary subject term: D003069
has primary subject term: D020179Q000517
has primary subject term: D016272
has primary subject term: D012651Q000706
has subject term: D000328
has subject term: D003430
has subject term: D005260
has subject term: D006077
has subject term: D006801
has subject term: D007730
has subject term: D008297
has subject term: D015995
has subject term: D012650
has subject term: D011795
has subject term: http://id.nlm.nih.gov/mesh/D000078329
source: Aviat Space Environ Med. 2005-04;76(4):395-8.
volume: 76

Tobacco: what your patients know, what you should know, what's on the horizon.
pmid: 16114703
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Rankin KV
      type: Person
      first name: K Vendrell
      last name: Rankin
      member of: Department of Public Health Sciences, Texas A & M University System Health Science Center, Baylor College of Dentistry, Dallas, USA.
  slot:
    index: 2
    item: Jones DL
      type: Person
      first name: Daniel L
      last name: Jones
created: 2005-8-24T09:00
date last updated: 2025-01-17
issued: 2005-06
dp: 2005 Jun
ISSN: 0040-4284
has issn l: 0040-4284
issue: 6
has NLM journal title abbreviation: Tex Dent J
publication name: Texas dental journal
language: eng
has national library of medicine journal id: 2984821R
derived from: NLM
starting page: 520
ending page: 4
has place of publication: United States
has primary subject term: D012907Q000009Q000453
has subject term: D007722
has subject term: D006801
has subject term: D012307
has subject term: D016540Q000379
source: Tex Dent J. 2005-06;122(6):520-4.
volume: 122

The tobacco buyout and the FDA.
pmid: 15459295
has PII: 351/14/1377
doi: 10.1056/NEJMp048218
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Schroeder SA
      type: Person
      first name: Steven A
      last name: Schroeder
      member of: Smoking Cessation Leadership Center, University of California, San Francisco, USA.
created: 2004-10-2T05:00
date last updated: 2025-01-17
issued: 2004-09-30
dp: 2004 Sep 30
e ISSN: 1533-4406
has issn l: 0028-4793
issue: 14
has NLM journal title abbreviation: N Engl J Med
publication name: The New England journal of medicine
language: eng
has national library of medicine journal id: 0255562
derived from: NLM
starting page: 1377
ending page: 80
has place of publication: United States
has primary subject term: D000383Q000191Q000331Q000639
has primary subject term: D033161
has primary subject term: D019460Q000191Q000331
has primary subject term: D014486
has subject term: D014481
source: N Engl J Med. 2004-09-30;351(14):1377-80.
volume: 351

Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma.
pmid: 15975525
abstract: We investigated the promotor hypermethylation status of multiple genes in 49 oral squamous cell carcinomas (OSCC), using the methylation-specific PCR (MSP) assay. The genes examined included p16INK4a, p14ARF, RB1, p21Waf1, p27Kip1, PTEN, p73, 0(6)-MGMT, and GST-P. Detailed clinicopathological data, such as patient age, sex, tobacco use, alcohol consumption, lesion site, degree of tumor differentiation, tumor size, presence of lymph node metastasis, and clinical stage, were collected for all 49 samples. Overall, gene methylation was detected in 46.9% (23/49) of samples and was closely correlated with tobacco use or/and alcohol consumption. Of the genes investigated, p16INK4a, p14ARF, 0(6)-MGMT, RB1, PTEN, and p27Kip1 were found to be methylated in 34.7%, 20.4%, 12.2%, 10.2%, 6.1%, and 4.1% of these 49 tumors, respectively, but methylation of p21Waf1, p73, and GST-P was not detected at all. Methylation frequencies were much higher for each gene when computed among informative cases only. Concurrent promotor hypermethylation of p16INK4a and p14ARF correlated significantly with tumor size, lymph node metastasis, and stage III/IV advanced OSCC; p14ARF hypermethylation, in particular, was significantly associated with both lymph node metastasis and late clinical stage. Our results suggest that DNA methylation of multiple genes, especially hypermethylation of the p14ARF promoter, is common in OSCC and is associated with the use of tobacco and/or alcohol consumption. For this type of cancer, the data further implicates gene methylation as playing an important role in tumor progression.
has PII: S1368-8375(05)00061-8
doi: 10.1016/j.oraloncology.2005.02.003
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ishida E
      type: Person
      first name: Eiwa
      last name: Ishida
      member of: Departments of Pathology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
  slot:
    index: 2
    item: Nakamura M
      type: Person
      first name: Mitsutoshi
      last name: Nakamura
  slot:
    index: 3
    item: Ikuta M
      type: Person
      first name: Miwa
      last name: Ikuta
  slot:
    index: 4
    item: Shimada K
      type: Person
      first name: Keiji
      last name: Shimada
  slot:
    index: 5
    item: Matsuyoshi S
      type: Person
      first name: Syuichi
      last name: Matsuyoshi
  slot:
    index: 6
    item: Kirita T
      type: Person
      first name: Tadaaki
      last name: Kirita
  slot:
    index: 7
    item: Konishi N
      type: Person
      first name: Noboru
      last name: Konishi
created: 2005-6-25T09:00
date last updated: 2025-01-17
issued: 2005-07
dp: 2005 Jul
ISSN: 1368-8375
has issn l: 1368-8375
issue: 6
has NLM journal title abbreviation: Oral Oncol
publication name: Oral oncology
language: eng
has national library of medicine journal id: 9709118
derived from: NLM
starting page: 614
ending page: 22
has place of publication: England
has primary subject term: D002294Q000235Q000473Q000556
has primary subject term: D019175
has primary subject term: D009062Q000235Q000473
has primary subject term: D011401Q000235
has primary subject term: D025803Q000235Q000378
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D000428Q000009
has subject term: D004273Q000235
has subject term: D018450
has subject term: D005260
has subject term: D006801
has subject term: D008207
has subject term: D008297
has subject term: D008875
has subject term: D009367
has subject term: D016133Q000379
source: Oral Oncol. 2005-07;41(6):614-22.
volume: 41

Characterization of cigarette tobacco by direct electrospray ionization-ion trap mass spectrometry (ESI-ITMS) analysis of the aqueous extract--a novel and simple approach.
pmid: 15563203
abstract: In support of the efforts to combat smuggling, as well as illegal sale and distribution of cigarettes, an analytical approach for the characterization of tobacco has been proposed and evaluated. It involves aqueous extraction of the filler tobaccos followed by direct analysis of the extracts by electrospray ionization-ion trap mass spectrometry (ESI-ITMS) in the negative mode. Typically, the deprotonated ions, [M - H](-), of organic acids (malic, citric, caffeic, quinic acid) and polyphenols (chlorogenic acid, rutin, scopoletin) were detected. MS/MS spectra of the ion at m/z 191, which is the [M - H](-) of quinic acid, citric acid, and scopoletin, and a fragment ion of chlorogenic acid were acquired. Significant differences in the MS and MS/MS spectra were observed between counterfeit samples and the corresponding authentic brand name cigarettes. Analysis of 25 commercial cigarettes showed that straight Virginia blends were readily distinguished from the blended products containing different tobacco types (Virginia, burley, and Oriental). The former exhibited consistently higher relative abundances of m/z 353 (chlorogenic acid) to m/z 133 (malic acid) in the MS spectra (0.9-1.2 vs 0.4-0.6) and higher intensity ratios of m/z 176 (scopoletin) to m/z 173 (0.4-0.8 vs 0.1-0.3) and of m/z 127 (quinic acid) to m/z 173 (0.7-1.0 vs 0.3-0.5) in the MS/MS spectra. Evidence is presented to demonstrate that the spectral differences were related not only to the tobacco type (Virginia, burley and Oriental) but also to the tobacco part (stem, lamina) used in the manufacture of the cigarettes.
doi: 10.1021/jf040203x
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ng LK
      type: Person
      first name: Lay-Keow
      last name: Ng
      member of: Laboratory and Scientific Services Directorate, Canada Border Services Agency, 79 Bentley Avenue, Ottawa, Ontario, Canada K1A 0L8. Rachel.Ng@ccra-adrc.gc.ca
  slot:
    index: 2
    item: Lafontaine P
      type: Person
      first name: Pierre
      last name: Lafontaine
  slot:
    index: 3
    item: Vanier M
      type: Person
      first name: Micheline
      last name: Vanier
created: 2004-11-26T09:00
date last updated: 2025-01-17
issued: 2004-12-01
dp: 2004 Dec 01
ISSN: 0021-8561
has issn l: 0021-8561
issue: 24
has NLM journal title abbreviation: J Agric Food Chem
publication name: Journal of agricultural and food chemistry
language: eng
has national library of medicine journal id: 0374755
derived from: NLM
starting page: 7251
ending page: 7
has place of publication: United States
has primary subject term: D021241Q000379
has subject term: D002109Q000032
has subject term: D019343Q000032
has subject term: D005419Q000032
has subject term: D008293Q000032
has subject term: D010636Q000032
has subject term: D059808
has subject term: D011801Q000032
has subject term: D012907
source: J Agric Food Chem. 2004-12-01;52(24):7251-7.
volume: 52

Preventing illegal tobacco and alcohol sales to minors through electronic age-verification devices: a field effectiveness study.
pmid: 15015859
abstract: Efforts to prohibit the sales of tobacco and alcohol products to minors are widespread. Electronic Age Verification (EAV) devices are one possible means to improve compliance with sales to minors laws. The purpose of this study was to evaluate the implementation and effectiveness of EAV devices in terms of the frequency and accuracy of age verification, as well as to examine the impact of EAV's on the retailer environment. Two study locations were selected: Tallahassee, Florida and Iowa City, Iowa. Retail stores were invited to participate in the study, producing a self-selected experimental group. Stores that did not elect to test the EAV's comprised the comparison group. The data sources included: 1) mystery shopper inspections: two pre- and five post-EAV installation mystery shopper inspections of tobacco and alcohol retailers; 2) retail clerk and manager interviews; and 3) customer interviews. The study found that installing EAV devices with minimal training and encouragement did not increase age verification and underage sales refusal. Surveyed clerks reported positive experiences using the electronic ID readers and customers reported almost no discomfort about being asked to swipe their IDs. Observations from this study support the need for a more comprehensive system for responsible retailing.
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Krevor B
      type: Person
      first name: Brad
      last name: Krevor
      member of: Heller School of Management and Health Policy, Brandeis University, Waltham, Massachusetts 02454-9110, USA. krevor@brandeis.edu
  slot:
    index: 2
    item: Capitman JA
      type: Person
      first name: John A
      last name: Capitman
  slot:
    index: 3
    item: Oblak L
      type: Person
      first name: Leslie
      last name: Oblak
  slot:
    index: 4
    item: Cannon JB
      type: Person
      first name: Joanna B
      last name: Cannon
  slot:
    index: 5
    item: Ruwe M
      type: Person
      first name: Mathilda
      last name: Ruwe
created: 2004-3-16T05:00
date last updated: 2025-01-17
issued: 2003
dp: 2003
ISSN: 0197-5897
has issn l: 0197-5897
issue: 3-4
has NLM journal title abbreviation: J Public Health Policy
publication name: Journal of public health policy
language: eng
has national library of medicine journal id: 8006508
derived from: NLM
starting page: 251
ending page: 68
has place of publication: England
has primary subject term: D000428Q000517
has primary subject term: D003132Q000295
has primary subject term: D000431
has primary subject term: D033242
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D000293
has subject term: D004581
has subject term: D005431
has subject term: D006801
has subject term: D007484
has subject term: D015397
source: J Public Health Policy. 2003;24(3-4):251-68.
volume: 24

The end of tobacco sales in Bhutan.
pmid: 15704290
doi: 10.1016/s1470-2045(05)01721-3
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Ahmad K
      type: Person
      first name: Khabir
      last name: Ahmad
created: 2005-2-12T09:00
date last updated: 2025-01-17
issued: 2005-02
dp: 2005 Feb
ISSN: 1470-2045
has issn l: 1470-2045
issue: 2
has NLM journal title abbreviation: Lancet Oncol
publication name: The Lancet. Oncology
language: eng
has national library of medicine journal id: 100957246
derived from: NLM
pg: 69
has place of publication: England
has primary subject term: D019460Q000191Q000331
has subject term: D001631
has subject term: D006801
has subject term: D020340Q000191
source: Lancet Oncol. 2005-02;6(2):69.
volume: 6

Residue formations of phosphorus hydride polymers and phosphorus oxyacids during phosphine gas fumigations of stored products.
pmid: 16390185
abstract: With the extent of international usage and the critical role phosphine gas (PH3) plays in commercial pest control, identification of the residual components deposited during fumigation is mandatory. It has been postulated that these infrequent residues are primarily composed of phosphoric acid or reduced forms of phosphoric acid [hypophosphorous acid (H3PO2) and phosphorous acid (H3PO3)], due to the oxidative degradation of phosphine. Using environmental scanning electron microscopy, gas phase Fourier transform infrared spectroscopy, and X-ray fluorescence spectroscopy, the structural elucidation and formation mechanism of the yellow amorphous polyhydric phosphorus polymers (P(x)H(y)) that occur in addition to the lower oxyacids of phosphorus in residues deposited during PH3 fumigations of select tobacco commodities are explored. This research determined that nitric oxide gas (or nitrogen dioxide) initiates residue formation of phosphorus hydride polymers and phosphorus oxyacids during PH3 fumigations of stored products.
doi: 10.1021/jf052315+
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Flora JW
      type: Person
      first name: Jason W
      last name: Flora
      member of: Research Center, Philip Morris USA, 4201 Commerce Road, Richmond, Virginia 23234, USA. jason.w.flora@pmusa.com
  slot:
    index: 2
    item: Byers LE
      type: Person
      first name: Loran E
      last name: Byers
  slot:
    index: 3
    item: Plunkett SE
      type: Person
      first name: Susan E
      last name: Plunkett
  slot:
    index: 4
    item: Faustini DL
      type: Person
      first name: Daryl L
      last name: Faustini
created: 2006-1-5T09:00
date last updated: 2025-01-17
issued: 2006-01-11
dp: 2006 Jan 11
ISSN: 0021-8561
has issn l: 0021-8561
issue: 1
has NLM journal title abbreviation: J Agric Food Chem
publication name: Journal of agricultural and food chemistry
language: eng
has national library of medicine journal id: 0374755
derived from: NLM
starting page: 107
ending page: 11
has place of publication: United States
has primary subject term: D005519Q000379
has primary subject term: D010720Q000008
has primary subject term: D017553Q000032
has subject term: D004350Q000032
has subject term: D005651
has subject term: D008854
has subject term: D010571Q000379
has subject term: D011108Q000032
has subject term: D017550
source: J Agric Food Chem. 2006-01-11;54(1):107-11.
volume: 54

Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration.
pmid: 17110447
abstract: The TGF-beta signaling pathway is a key organizer of injury and immune responses, and recent studies suggest it fulfills critical roles in CNS function and maintenance. TGF-beta receptor activation results in phosphorylation of Smad proteins, which subsequently translocate to the nucleus to regulate gene transcription by binding to Smad binding elements (SBE). Using SBE-luciferase reporter mice, we recently discovered that the brain has the highest Smad baseline activity of any major organ in the mouse, and we now demonstrate that this signal is primarily localized to pyramidal neurons of the hippocampus. In vivo excitatory stimulation with kainic acid (KA) resulted in an increase in luciferase activity and phosphorylated Smad2 (Smad2P), and nuclear translocation of Smad2P in hippocampal CA3 neurons correlated significantly with luciferase activity. Although this activation was most prominent at 24 h after KA administration in neurons, Smad2P immunoreactivity gradually increased in astrocytes and microglial cells at 3 and 5 days, consistent with reactive gliosis. Bioluminescence measured over the skull in living mice peaked at 12-72 h and correlated with the extent of microglial activation and pathological markers of neurodegeneration 5 days after injury. Treatment with the glutamate receptor antagonist MK-801 strongly reduced bioluminescence and pathology. These results show that Smad2 signaling is a sensitive marker of neuronal activation and CNS injury that can be used to monitor KA-induced neuronal degeneration. This and related mouse models may provide valuable tools to study mechanisms and treatments for neurodegeneration.
has PII: 0605077103
doi: 10.1073/pnas.0605077103
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Luo J
      type: Person
      first name: Jian
      last name: Luo
      member of: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  slot:
    index: 2
    item: Lin AH
      type: Person
      first name: Amy H
      last name: Lin
  slot:
    index: 3
    item: Masliah E
      type: Person
      first name: Eliezer
      last name: Masliah
  slot:
    index: 4
    item: Wyss-Coray T
      type: Person
      first name: Tony
      last name: Wyss-Coray
created: 2006-11-18T09:00
date last updated: 2025-01-17
issued: 2006-11-28
dp: 2006 Nov 28
ISSN: 0027-8424
has issn l: 0027-8424
issue: 48
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
starting page: 18326
ending page: 31
has place of publication: United States
has primary subject term: D009410Q000378Q000473
has primary subject term: D015398
has primary subject term: D051785Q000378
has subject term: D000818
has subject term: D015415
has subject term: D002478
has subject term: D002490Q000187Q000293Q000378Q000473
has subject term: D016291Q000494
has subject term: D017930Q000235
has subject term: D007608Q000494
has subject term: D051379
has subject term: D018613
source: Proc Natl Acad Sci U S A. 2006-11-28;103(48):18326-31.
volume: 103

Guidance for research and testing to reduce tobacco toxicant exposure.
pmid: 16298717
has PII: Q535956517406802
doi: 10.1080/14622200500415265
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Henningfield JE
      type: Person
      first name: Jack E
      last name: Henningfield
      member of: Pinney Associates and Johns Hopkins University School of Medicine, Baltimore, MD 20814, USA. jhenning@pinneyassociates.com
  slot:
    index: 2
    item: Burns DM
      type: Person
      first name: David M
      last name: Burns
  slot:
    index: 3
    item: Dybing E
      type: Person
      first name: Erik
      last name: Dybing
created: 2005-11-22T09:00
date last updated: 2025-01-17
issued: 2005-12
dp: 2005 Dec
ISSN: 1462-2203
has issn l: 1462-2203
issue: 6
has NLM journal title abbreviation: Nicotine Tob Res
publication name: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
language: eng
has national library of medicine journal id: 9815751
derived from: NLM
starting page: 821
ending page: 6
has place of publication: England
has primary subject term: D000393Q000032
has primary subject term: D004781Q000517
has primary subject term: D012107Q000592
has primary subject term: D016540Q000379
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: D014028Q000517
has subject term: D000329
has subject term: D033161
has subject term: D017408
has subject term: D006801
has subject term: D019460Q000331
has subject term: D014029Q000517
has subject term: D014481
source: Nicotine Tob Res. 2005-12;7(6):821-6.
volume: 7

The future of tobacco regulation: a response to a proposal for fundamental institutional change.
pmid: 16885583
abstract: There is much debate about the future of tobacco regulation. Some have argued that to achieve maximum possible reduction in the harm tobacco causes, new regulatory models that involve fundamental institutional change must be adopted. The tobacco industry will continue to undermine tobacco control, and, so it is argued, we must change the way in which it operates if we are to be able to make the necessary progress. Such proposals may have an immediate appeal, especially for those frustrated that progress in tobacco control is not as rapid as they would hope--with all the avoidable loss of life and livelihoods that that entails--but they need to be carefully analysed and assessed, and much thought must be applied before spending time and resources advocating for them. One such proposal, advanced by Borland, involves the establishment of a monopsonistic statutory purchasing agency and wholesale distributor of tobacco products. Borland argues the relative benefits of such a model as compared to a more conventional model. On close examination, the benefits of the Borland proposal, as compared to the conventional model, appear overstated, and the Borland proposal introduces significant regulatory problems. There is still much that can be achieved in tobacco regulation through more conventional approaches, and within the existing system . We should be wary of allowing the understandable allure of new or radical approaches to distract us from this reality.
has PII: 15/4/333
doi: 10.1136/tc.2006.016014
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Liberman J
      type: Person
      first name: Jonathan
      last name: Liberman
      member of: VicHealth Centre for Tobacco Control, The Cancer Council Victoria, 100 Drummond Street, Carlton 3053, Victoria, Australia. jonathan.liberman@cancervic.org.au
created: 2006-8-4T09:00
date last updated: 2025-01-17
issued: 2006-08
dp: 2006 Aug
e ISSN: 1468-3318
has issn l: 0964-4563
issue: 4
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 333
ending page: 8
has place of publication: England
has primary subject term: D040541Q000331
has primary subject term: D008962
has primary subject term: D011634
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: D012926Q000379
has primary subject term: D019460Q000331
has subject term: D033161
has subject term: D006801
has subject term: D011356Q000331
source: Tob Control. 2006-08;15(4):333-8.
volume: 15

Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells.
pmid: 16582591
abstract: Frequent users of smokeless tobacco (ST) have an increased risk for developing oral cancer. Nicotine and its derivatives may contribute to tumorigenesis through stimulation of nicotinic acetylcholine receptors (nAChRs) in target cells. Emerging evidence indicates that nAChRs can be stimulated by the nicotine-derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) that can induce oral cavity tumors in laboratory animals. This study was designed to elucidate the receptor-mediated mechanisms of the initiation and progression of NNK-, and NNN-induced oral cancers. We used Het-1A cells that were found to express alpha3, alpha5, alpha7, alpha9, beta2 and beta4 nAChR subunits. Both NNK and NNN competed with nicotinic radioligands for binding to Het-1A cells. NNK showed a higher than NNN affinity to the [3H]nicotine-labeled binding sites, and NNN-to the [3H]epibatidine-sensitive nAChRs. NNK and NNN increased proliferative potential of Het-1A cells and produced an anti-apoptotic effect, which was alleviated by antagonists. alpha-Bungarotoxin was most effective against NNK and mecamylamine against NNN. Treatment of Het-1A cells with either NNK or NNN led to acquisition of capability of anchorage independent growth and ability to produce tumors in nude mice, both of which can be by inhibited by antagonists. To elucidate the signaling mechanisms, we studied transcription of the genes encoding the cell cycle, apoptosis and signal transduction regulators at both the mRNA and protein levels. The Het-1A cells stimulated with nitrosamines showed multifold increases of the mRNA transcripts encoding PCNA and Bcl-2, and upregulated expression of the transcription factors GATA3, nuclear factor-kappaB, and STAT-1. The STAT-1 protein-binding activity induced by NNK and NNN correlated with elevated gene expression. The obtained results establish the role of specific nAChR subtypes in tobacco-related carcinogenesis and open a novel avenue fo[cell cut: 2030 characters, first 2000 kept]
has PII: 2601
doi: 10.4161/cbt.5.5.2601
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Arredondo J
      type: Person
      first name: Juan
      last name: Arredondo
      member of: Department of Dermatology, University of California at Davis, Davis, California, USA.
  slot:
    index: 2
    item: Chernyavsky AI
      type: Person
      first name: Alex I
      last name: Chernyavsky
  slot:
    index: 3
    item: Grando SA
      type: Person
      first name: Sergei A
      last name: Grando
created: 2006-4-4T09:00
date last updated: 2025-01-17
issued: 2006-05
dp: 2006 May
ISSN: 1538-4047
has issn l: 1538-4047
issue: 5
has NLM journal title abbreviation: Cancer Biol Ther
publication name: Cancer biology & therapy
language: eng
has national library of medicine journal id: 101137842
derived from: NLM
starting page: 511
ending page: 7
has place of publication: United States
has primary subject term: D002273Q000494
has primary subject term: D004847Q000187Q000378
has primary subject term: D004947Q000166Q000187Q000378
has primary subject term: D009602Q000494
has primary subject term: D011978Q000145Q000235Q000378
has subject term: D006801
has subject term: D017209Q000187
has subject term: D002453Q000187
has subject term: D002478
has subject term: D050990Q000235Q000378
has subject term: D016328Q000235Q000378
has subject term: D018809Q000235Q000378
has subject term: D019253Q000235Q000378
has subject term: D020133
has subject term: D012333Q000235Q000378
has subject term: D050794Q000235Q000378
has subject term: D009538
source: Cancer Biol Ther. 2006-05;5(5):511-7.
volume: 5

[The carcinogenic effects of tobacco. Monatsschrift für Krebsbekämpfung Vol. 8, Issue 5, 1940].
pmid: 16799736
has PII: S0042-96862006000600021
doi: /S0042-96862006000600021
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Roffo AH
      type: Person
      first name: A H
      last name: Roffo
created: 2006-6-27T09:00
date last updated: 2025-01-17
issued: 2006-06
dp: 2006 Jun
ISSN: 0042-9686
has issn l: 0042-9686
issue: 6
has NLM journal title abbreviation: Bull World Health Organ
publication name: Bulletin of the World Health Organization
language: engger
has national library of medicine journal id: 7507052
derived from: NLM
starting page: 497
ending page: 502
has place of publication: Switzerland
has primary subject term: D015197Q000266
has primary subject term: D003033Q000737Q000633
has primary subject term: D009369Q000209Q000401
has primary subject term: D012907Q000009
has subject term: D000818
has subject term: D001118
has subject term: D001580Q000633
has subject term: D005260
has subject term: D049673
has subject term: D006801
has subject term: D008297
has subject term: D011817
has subject term: D012106Q000266
source: Bull World Health Organ. 2006-06;84(6):497-502.
volume: 84

Comparing attitudes about legal sanctions and teratogenic effects for cocaine, alcohol, tobacco and caffeine: a randomized, independent samples design.
pmid: 16722564
abstract: Establishing more sensible measures to treat cocaine-addicted mothers and their children is essential for improving U.S. drug policy. Favorable post-natal environments have moderated potential deleterious prenatal effects. However, since cocaine is an illicit substance having long been demonized, we hypothesized that attitudes toward prenatal cocaine exposure would be more negative than for licit substances, alcohol, nicotine and caffeine. Further, media portrayals about long-term outcomes were hypothesized to influence viewers' attitudes, measured immediately post-viewing. Reducing popular crack baby stigmas could influence future policy decisions by legislators. In Study 1, 336 participants were randomly assigned to 1 of 4 conditions describing hypothetical legal sanction scenarios for pregnant women using cocaine, alcohol, nicotine or caffeine. Participants rated legal sanctions against pregnant women who used one of these substances and risk potential for developing children. In Study 2, 139 participants were randomly assigned to positive, neutral and negative media conditions. Immediately post-viewing, participants rated prenatal cocaine-exposed or non-exposed teens for their academic performance and risk for problems at age 18.Participants in Study 1 imposed significantly greater legal sanctions for cocaine, perceiving prenatal cocaine exposure as more harmful than alcohol, nicotine or caffeine. A one-way ANOVA for independent samples showed significant differences, beyond .0001. Post-hoc Sheffe test illustrated that cocaine was rated differently from other substances. In Study 2, a one-way ANOVA for independent samples was performed on difference scores for the positive, neutral or negative media conditions about prenatal cocaine exposure. Participants in the neutral and negative media conditions estimated significantly lower grade point averages and more problems for the teen with prenatal cocaine exposure than for the non-exposed teen beyond .0001 alpha lev[cell cut: 2516 characters, first 2000 kept]
has PII: 1747-597X-1-4
doi: 10.1186/1747-597X-1-4
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ginsburg HJ
      type: Person
      first name: Harvey J
      last name: Ginsburg
      member of: Department of Psychology, Texas State University - San Marcos, San Marcos, Texas 78666, USA. hg01@txstate.edu
  slot:
    index: 2
    item: Raffeld P
      type: Person
      first name: Paul
      last name: Raffeld
  slot:
    index: 3
    item: Alanis KL
      type: Person
      first name: Kelly L
      last name: Alanis
  slot:
    index: 4
    item: Boyce AS
      type: Person
      first name: Angela S
      last name: Boyce
created: 2006-5-26T09:00
date last updated: 2025-01-17
issued: 2006-02-01
dp: 2006 Feb 01
ISSN: 1747-597X
has issn l: 1747-597X
has NLM journal title abbreviation: Subst Abuse Treat Prev Policy
publication name: Substance abuse treatment, prevention, and policy
language: eng
has national library of medicine journal id: 101258060
derived from: NLM
pg: 4
has place of publication: England
has primary subject term: D000434Q000009
has primary subject term: D001290
has primary subject term: D002110Q000009
has primary subject term: D003042Q000009
has primary subject term: D013287Q000009Q000331
has primary subject term: D013723
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D011247
has subject term: D008402
has subject term: D008431
has subject term: D012107
has subject term: D013240
has subject term: D014028Q000009
source: Subst Abuse Treat Prev Policy. 2006-02-01;1():4.
volume: 1

[Alcohol, tobacco and cannabis: Review of teratogenicity studies in animals].
pmid: 16971157
abstract: Despite an intensive national campaign of information, the drugs most frequently consumed by young adults undoubtedly continue to be alcohol, tobacco and cannabis. If the impact of these drugs on the health of the consumers can be evaluated in conjunction with the clinical and epidemiologic data, the consequences on the embryo due to their consumption by the pregnant women can be appreciated thanks to the abundant literature describing their effects in the gravid animal. Taking into account the abundant literature available in multiple animal species, the zero drug recommendation should be widely diffused to pregnant women.
has PII: S1297-9589(06)00281-5
doi: 10.1016/j.gyobfe.2006.07.029
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Spézia F
      type: Person
      first name: F
      last name: Spézia
      member of: Animal toxicology and safety, Novexel SA, parc Biocitech, 102, route de Noisy, 93230 Romainville, France. francois.spezia@novexel.com
created: 2006-9-15T09:00
date last updated: 2025-01-17
issued: 2006-10
dp: 2006 Oct
ISSN: 1297-9589
has issn l: 1297-9589
issue: 10
has NLM journal title abbreviation: Gynecol Obstet Fertil
publication name: Gynecologie, obstetrique & fertilite
language: fre
has national library of medicine journal id: 100936305
derived from: NLM
starting page: 940
ending page: 4
has place of publication: France
has primary subject term: D000014
has primary subject term: D002188Q000633
has primary subject term: D000431Q000633
has subject term: D000818
has subject term: D005260
has subject term: D006801
has subject term: D011247
source: Gynecol Obstet Fertil. 2006-10;34(10):940-4.
volume: 34

http://rdf.ncbi.nlm.nih.gov/pubmed/16845788
pmid: 16845788
doi: 10.1086/532112
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Sen S
      type: Person
      first name: Sudipta
      last name: Sen
created: 2006-7-19T09:00
date last updated: 2025-01-17
issued: 2002
dp: 2002
ISSN: 0002-8762
has issn l: 0002-8762
issue: 1
has NLM journal title abbreviation: Am Hist Rev
publication name: The American historical review
language: eng
has national library of medicine journal id: 01210290R
derived from: HMD
starting page: 164
ending page: 5
has place of publication: England
has primary subject term: D019460Q000266
has subject term: D049672
has subject term: D049673
has subject term: D006113
has subject term: D014481
source: Am Hist Rev. 2002;107(1):164-5.
title: The global cigarette: origins and evolution of British American Tobacco, 1880-1945. [Review of: Cox, H. The global cigarette: origins and evolution of British American Tobacco, 1880-1945. New York: Oxford U. Pr., 2000].
volume: 107

Altered states: opium and tobacco compared.
pmid: 17654813
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Berridge V
      type: Person
      first name: V
      last name: Berridge
created: 2007-7-28T09:00
date last updated: 2025-01-17
issued: 2001
dp: 2001
ISSN: 0037-783X
has issn l: 0037-783X
issue: 3
has NLM journal title abbreviation: Soc Res (New York)
publication name: Social research
language: eng
has national library of medicine journal id: 20810180R
derived from: HMD
starting page: 655
ending page: 75
has place of publication: United States
has primary subject term: D033161Q000266
has primary subject term: D009892Q000191Q000266
has primary subject term: D011634Q000191Q000266Q000331
has subject term: D003466
has subject term: D049672
has subject term: D049673
has subject term: D007603Q000266
has subject term: D011635Q000266Q000331
has subject term: D011640
has subject term: D012922Q000266
has subject term: D011049Q000191Q000266Q000331
has subject term: D012952Q000191Q000266Q000331
has subject term: D019460Q000191Q000266Q000331
has subject term: D006113Q000208
source: Soc Res (New York). 2001;68(3):655-75.
volume: 68

Field analysis of acetaldehyde in mainstream tobacco smoke using solid-phase microextraction and a portable gas chromatograph.
pmid: 18533163
abstract: Acetaldehyde is generated in the mainstream tobacco smoke mainly from the pyrolysis (and oxidative pyrolysis) of carbohydrates that are present in tobacco plant, cigarette paper, and also used as additives in tobacco. Acetaldehyde has been classified as an animal carcinogen, and may be cytotoxic or genetoxic. Owing to its high volatility and reactivity, it is difficult to accurately measure it, especially on site. In this work, a novel analytical method based on collection and simultaneous derivatization in water, solid-phase microextraction (SPME), and portable gas chromatography (GC) analysis has been developed for the field and rapid analysis of acetaldehyde in the mainstream tobacco smoke. In the proposed method, acetaldehyde in mainstream tobacco smoke was collected in 1 ml water, and derivatizated with O-2,3,4,5,6-(pentafluorobenzyl)hydroxylamine. The formed acetaldehyde oximes were headspace extracted by a divinylbenzene/carboxen/polydimethylsiloxane fiber at 30 degrees C for 10 min, with a stirring rate of 1100 rpm. The acetaldehyde oximes extracted on the fiber were desorbed and analyzed rapidly by portable GC. The method validations including detection limit, recovery, precision and linearity were studied. It was found that the proposed method required the whole analysis time 27 min, and provided low detection limit of 0.04774 mg/ml, good recovery of 85%, RSD value 6.7%, and linear range 0.0716-0.7160 mg/ml (r(2)=0.997). The obtained results demonstrated that SPME-portable GC is a simple, rapid and solvent-free method for the field analysis of acetaldehyde. Finally, the proposed method was further applied to the quantification of acetaldehyde in mainstream tobacco smoke of five different brands.
has PII: S0021-9673(08)00886-8
doi: 10.1016/j.chroma.2008.05.050
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lin H
      type: Person
      first name: Huaqing
      last name: Lin
      member of: Department of Chemistry, Fudan University, Shanghai 200433, China.
  slot:
    index: 2
    item: Ye Q
      type: Person
      first name: Qing
      last name: Ye
  slot:
    index: 3
    item: Deng C
      type: Person
      first name: Chunhui
      last name: Deng
  slot:
    index: 4
    item: Zhang X
      type: Person
      first name: Xiangmin
      last name: Zhang
created: 2008-6-6T09:00
date last updated: 2025-01-17
issued: 2008-07-11
dp: 2008 Jul 11
ISSN: 0021-9673
has issn l: 0021-9673
has NLM journal title abbreviation: J Chromatogr A
publication name: Journal of chromatography. A
language: eng
has national library of medicine journal id: 9318488
derived from: NLM
starting page: 34
ending page: 7
has place of publication: Netherlands
has primary subject term: D000079Q000032Q000737
has primary subject term: D002849Q000295Q000379
has primary subject term: D052617Q000295Q000379
has subject term: D015203
source: J Chromatogr A. 2008-07-11;1198-1199():34-7.
volume: 1198-1199

[Change of the trace elements content from cigarettes (tobacco) to its ash and to look at harm of stuck cigarette].
pmid: 18051543
abstract: After the digestion of cigarettes and its ash are digested with concentrated nitric acid and perchloric acid, the change in mineral elements (Ca, Mg, Cu, Fe, Zn, Mn, Ni, Co, Cr, Pb and Cd) content in the cigarette and its ash were determined by flame atomic absorptionspectrophotometry. The experimental results showed that there were differences between the cigarette (tobacco) and its ash, especially, the contents of Pb and Cd harmful to human health in the ash are lowed 26.4% and 44.2%, respectively. It is concluded that a part of Pb and Cd in the cigarette passes through the human lung respiration and air environment.
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Wang NX
      type: Person
      first name: Nai-Xing
      last name: Wang
      member of: Center for Experiment Teaching, School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, China. Naixingwang@163.com
  slot:
    index: 2
    item: Cui XG
      type: Person
      first name: Xue-Gui
      last name: Cui
  slot:
    index: 3
    item: Han L
      type: Person
      first name: Ling
      last name: Han
  slot:
    index: 4
    item: Zhaxi Y
      type: Person
      first name: Yongxi
      last name: Zhaxi
  slot:
    index: 5
    item: Dawa Z
      type: Person
      first name: Zhuoga
      last name: Dawa
created: 2007-12-7T09:00
date last updated: 2025-01-17
issued: 2007-09
dp: 2007 Sep
ISSN: 1000-0593
has issn l: 1000-0593
issue: 9
has NLM journal title abbreviation: Guang Pu Xue Yu Guang Pu Fen Xi
publication name: Guang pu xue yu guang pu fen xi = Guang pu
language: chi
has national library of medicine journal id: 9424805
derived from: NLM
starting page: 1845
ending page: 7
has place of publication: China
has primary subject term: D012907Q000009
has primary subject term: D014028Q000009Q000032
has primary subject term: D014131Q000032
has subject term: D006801
source: Guang Pu Xue Yu Guang Pu Fen Xi. 2007-09;27(9):1845-7.
volume: 27

[Tobacco contact dermatitis caused by sensitivity to sorbic acid].
pmid: 18342097
abstract: Contact dermatitis caused by tobacco is rare and poorly understood. In this paper, we report what is to our knowledge, the first case of tobacco contact dermatitis with identification of the causative agent.A 46-year-old man was hospitalised for diffuse dermatitis originating in the left leg. Subsequent epicutaneous tests indicated that this dermatitis was ascribable to sensitisation to the sorbic acid present in Fucidin cream applied around a chronic wound. A persistent plaque of eczema observed on the day of examination opposite the patient's right trouser pocket suggested the implication of tobacco powder with which the pocket was soiled. An epicutaneous test using tobacco (moistened in water) proved positive (++ at 48 and 72 h). This tobacco contained sorbic acid, used as a preservative.The positive test for sorbic acid was relevant not only regarding the lesions on the patient's legs (application of a topical cream containing sorbic acid) but also for the lesion on the patient's thigh and for palmar dyshidrosis (through contact with strands of loose rolling tobacco). To our knowledge, this is the first recorded case of contact dermatitis caused by sorbic acid in tobacco.
has PII: S0151-9638(07)00028-2
doi: 10.1016/j.annder.2007.05.001
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Grange-Prunier A
      type: Person
      first name: A
      last name: Grange-Prunier
      member of: Service de dermatologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France. agrange@chu-reims.fr
  slot:
    index: 2
    item: Bezier M
      type: Person
      first name: M
      last name: Bezier
  slot:
    index: 3
    item: Perceau G
      type: Person
      first name: G
      last name: Perceau
  slot:
    index: 4
    item: Bernard P
      type: Person
      first name: P
      last name: Bernard
created: 2008-3-18T09:00
date last updated: 2025-01-17
issued: 2008-02
dp: 2008 Feb
ISSN: 0151-9638
has issn l: 0151-9638
issue: 2
has NLM journal title abbreviation: Ann Dermatol Venereol
publication name: Annales de dermatologie et de venereologie
language: fre
has national library of medicine journal id: 7702013
derived from: NLM
starting page: 135
ending page: 8
has place of publication: France
has primary subject term: D003877Q000209
has primary subject term: D007868Q000139
has primary subject term: D011310Q000009
has primary subject term: D013011Q000009
has subject term: D005672
has subject term: D006801
has subject term: D008297
has subject term: D008875
source: Ann Dermatol Venereol. 2008-02;135(2):135-8.
volume: 135

[Tobacco and morphology: pulmonary diseases].
pmid: 17632677
abstract: Tobacco is implicated in multisystemic carcinogenesis through more than fifty identified carcinogenic metabolites that produce mutations responsible for alterations in cell cycle, immune response and endocrine regulation. Is one of nine risk factors identified in one third of cancer deaths together with obesity, sedentary, alcohol consumption, sexual promiscuity, drug addiction, and open and closed air contamination. Answering for cardiovascular diseases as the first cause of death in civilized world, tobacco is also pointed as the major factor implicated in the development of COPD (chronic obstructive pulmonary disease), RB-ILD (respiratory bronchiolitis and interstitial lung disease), DIP (desquamative interstitial pneumonia), bronchiolitis and bronchiolocentric interstitial fibrosis, Langerhans cells histiocytosis, eosinophilic pneumonia, sarcoidosis, epidermoid metaplasia in respiratory epithelium and lung cancer. The chronic tobacco induced inflammatory state is the basis for the acquisition of genetic alterations dependent on the tobacco contaminants.
has PII: S0873-2159(15)30357-3
doi: 10.1016/s0873-2159(15)30357-3
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Carvalho L
      type: Person
      first name: Lina
      last name: Carvalho
      member of: Faculdade de Medicina da Universidade de Coimbra, Coimbra.
created: 2007-7-17T09:00
date last updated: 2025-01-17
ISSN: 0873-2159
has issn l: 0873-2159
issue: 3
has NLM journal title abbreviation: Rev Port Pneumol
publication name: Revista portuguesa de pneumologia
language: por
has national library of medicine journal id: 9813736
derived from: NLM
starting page: 383
ending page: 9
has place of publication: Spain
has primary subject term: D008171Q000209
has primary subject term: D012907Q000009
has subject term: D006801
has subject term: D008175Q000209
has subject term: http://id.nlm.nih.gov/mesh/D000074606
source: Rev Port Pneumol. ;13(3):383-9.
volume: 13

Big tobacco and moto-GP: why no warnings on the motorcycles?
pmid: 17557579
doi: 10.1177/030089160709300225
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Boffi R
      type: Person
      first name: Roberto
      last name: Boffi
  slot:
    index: 2
    item: De Marco C
      type: Person
      first name: Cinzia
      last name: De Marco
  slot:
    index: 3
    item: Mazza R
      type: Person
      first name: Roberto
      last name: Mazza
  slot:
    index: 4
    item: Rossetti E
      type: Person
      first name: Edoardo
      last name: Rossetti
  slot:
    index: 5
    item: Ruprecht A
      type: Person
      first name: Ario
      last name: Ruprecht
  slot:
    index: 6
    item: Pozzati I
      type: Person
      first name: Ivan
      last name: Pozzati
  slot:
    index: 7
    item: Invernizzi G
      type: Person
      first name: Giovanni
      last name: Invernizzi
created: 2007-6-15T09:00
date last updated: 2025-01-17
ISSN: 0300-8916
has issn l: 0300-8916
issue: 2
has NLM journal title abbreviation: Tumori
publication name: Tumori
language: eng
has national library of medicine journal id: 0111356
derived from: NLM
starting page: 228
ending page: 9
has place of publication: United States
has primary subject term: D000329Q000592
has primary subject term: D011356Q000592
has subject term: D015386
has subject term: D009049
source: Tumori. ;93(2):228-9.
volume: 93

Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis.
pmid: 17457978
abstract: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts.Total RNA was isolated from tumor and matched normal tissue of 16 patients with esophageal squamous cell carcinoma. Pooled tumor tissue RNA was labeled with Cy3-dUTP and pooled normal tissue RNA was labeled with Cy5-dUTP by direct labeling method. The labeled probes were hybridized with human 10K cDNA chip and expression profiles were analyzed by Genespring GX V 7.3 (Silicon Genetics).Nine hundred twenty three genes were differentially expressed. Of these, 611 genes were upregulated and 312 genes were downregulated. Using stringent criteria (P < or = 0.05 and > or = 1.5 fold change), 127 differentially expressed genes (87 upregulated and 40 downregulated) were identified in tumor tissue. On the basis of Gene Ontology, four different molecular functional pathways (MAPK pathway, G-protein coupled receptor family, ion transport activity, and serine or threonine kinase activity) were most significantly upregulated and six different molecular functional pathways (structural constituent of ribosome, endopeptidase inhibitor activity, structural constituent of cytoskeleton, antioxidant activity, acyl group transferase activity, eukaryotic translation elongation factor activity) were most significantly downregulated.Several genes that showed alterations in our study have also been reported from a high incidence area of esophageal cancer in China. This indicates that molecular profiles of esophageal cancer in these two different geographic locations are highly consistent.
doi: 10.3748/wjg.v13.i9.1438
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Chattopadhyay I
      type: Person
      first name: Indranil
      last name: Chattopadhyay
      member of: Institute of Pathology, Indian Council of Medical Research, Safdarjang Hospital Campus, Post Box No. 4909, New Delhi 110029, India.
  slot:
    index: 2
    item: Kapur S
      type: Person
      first name: Sujala
      last name: Kapur
  slot:
    index: 3
    item: Purkayastha J
      type: Person
      first name: Joydeep
      last name: Purkayastha
  slot:
    index: 4
    item: Phukan R
      type: Person
      first name: Rupkumar
      last name: Phukan
  slot:
    index: 5
    item: Kataki A
      type: Person
      first name: Amal
      last name: Kataki
  slot:
    index: 6
    item: Mahanta J
      type: Person
      first name: Jagadish
      last name: Mahanta
  slot:
    index: 7
    item: Saxena S
      type: Person
      first name: Sunita
      last name: Saxena
created: 2007-4-26T09:00
date last updated: 2025-01-17
issued: 2007-03-07
dp: 2007 Mar 07
ISSN: 1007-9327
has issn l: 1007-9327
issue: 9
has NLM journal title abbreviation: World J Gastroenterol
publication name: World journal of gastroenterology
language: eng
has national library of medicine journal id: 100883448
derived from: NLM
starting page: 1438
ending page: 44
has place of publication: United States
has primary subject term: D004273Q000235
has primary subject term: D004938Q000453Q000209Q000235
has primary subject term: D020869Q000379
has primary subject term: D020411Q000379
has subject term: D000368
has subject term: D001114Q000009
has subject term: D001706
has subject term: D004947Q000473
has subject term: D015972
has subject term: D006801
has subject term: D015994
has subject term: D007194Q000453Q000208
has subject term: D008297
has subject term: D008875
has subject term: D012307
source: World J Gastroenterol. 2007-03-07;13(9):1438-44.
volume: 13

How do different cigarette design features influence the standard tar yields of popular cigarette brands sold in different countries?
pmid: 18768453
abstract: To examine the associations among cigarette design features and tar yields of leading cigarette brands sold in the United States, Canada, Australia and the United Kingdom.Government reports and numbers listed on packs were used to obtain data on International Organization for Standardization (ISO)/Federal Trade Commission (FTC) yields for the tar of 172 cigarette varieties sold in the United States, Canada, Australia and the United Kingdom. We used standardised methods to measure the following 11 cigarette design parameters: filter ventilation, cigarette pressure drop, filter pressure drop, tobacco rod length, filter length, cigarette diameter, tipping paper length, tobacco weight, filter weight, rod density and filter density.Filter ventilation was found to be the predominant design feature accounting for the variations between brands in ISO/FTC tar yields in each of the four countries. After accounting for filter ventilation, design parameters such as overwrap length, tobacco weight and rod density played comparatively minor roles in determining tar yields.Variation in ISO/FTC tar yields are predicted by a limited set of cigarette design features, especially filter ventilation, suggesting that governments should consider mandatory disclosure of cigarette design parameters as part of comprehensive tobacco product regulations.
has PII: 17/Suppl_1/i1
doi: 10.1136/tc.2006.019166
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: O'Connor RJ
      type: Person
      first name: R J
      last name: O'Connor
      member of: Department of Health Behavior, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. richard.oconnor@roswellpark.org
  slot:
    index: 2
    item: Hammond D
      type: Person
      first name: D
      last name: Hammond
  slot:
    index: 3
    item: McNeill A
      type: Person
      first name: A
      last name: McNeill
  slot:
    index: 4
    item: King B
      type: Person
      first name: B
      last name: King
  slot:
    index: 5
    item: Kozlowski LT
      type: Person
      first name: L T
      last name: Kozlowski
  slot:
    index: 6
    item: Giovino GA
      type: Person
      first name: G A
      last name: Giovino
  slot:
    index: 7
    item: Cummings KM
      type: Person
      first name: K M
      last name: Cummings
created: 2008-9-11T09:00
date last updated: 2025-01-17
issued: 2008-09
dp: 2008 Sep
e ISSN: 1468-3318
has issn l: 0964-4563
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: i1
ending page: 5
has place of publication: England
has primary subject term: D012906Q000032
has primary subject term: D013638Q000032
has subject term: D003257
has subject term: D005374Q000295
has subject term: D006801
has subject term: D016014
has subject term: D008422Q000379
has subject term: D012907
has subject term: D019460
source: Tob Control. 2008-09;17 Suppl 1():i1-5.
volume: 17 Suppl 1

Existing technologies to reduce specific toxicant emissions in cigarette smoke.
pmid: 18768458
abstract: The World Health Organization Tobacco Product Regulation (TobReg) study group has proposed emissions level performance standards for nine toxicants (NNN, NNK, acetaldehyde, acrolein, 1,3-butadiene, CO, BaP, benzene and formaldehyde, all expressed as micrograms per milligram nicotine as measured under the Canadian intensive method) in cigarette smoke for parties to the FCTC in conjunction with regular monitoring of emissions of nine other toxicants of interest, nicotine and nicotine-free dry particulate matter (NFDPM, or tar ).We examined the published literature and publicly available tobacco industry documents to determine the extent to which existing available technologies can be applied to reduce the emissions of the specified toxicants in cigarette smoke.Agricultural practices (for example, fertilisers, curing), plant characteristics (for example, protein content, nicotine content), tobacco blending (for example, American blend vs Virginia blend) and cigarette design (for example, additives, filters, paper) issues all have roles in the generation and reduction of specific smoke toxicants. The tobacco industry has explored a number of technologies, including selective filtration, changes to curing practices and rod additives to reduce specific toxicants.Technologies exist to reduce the toxicants identified by TobReg. The extent to which the industry is able to simultaneously reduce toxicants, however, is unknown.
has PII: 17/Suppl_1/i39
doi: 10.1136/tc.2007.023689
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: O'Connor RJ
      type: Person
      first name: R J
      last name: O'Connor
      member of: Department of Health Behavior, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA. Richard.Oconnor@roswellpark.org
  slot:
    index: 2
    item: Hurley PJ
      type: Person
      first name: P J
      last name: Hurley
created: 2008-9-11T09:00
date last updated: 2025-01-17
issued: 2008-09
dp: 2008 Sep
e ISSN: 1468-3318
has issn l: 0964-4563
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: i39
ending page: 48
has place of publication: England
has primary subject term: D040261
has primary subject term: D015386Q000032
has primary subject term: D012906Q000032
has primary subject term: D013672Q000379
has subject term: D006801
has subject term: D003257
has subject term: D012907Q000009
has subject term: D019460Q000379
has subject term: D009538
source: Tob Control. 2008-09;17 Suppl 1():i39-48.
volume: 17 Suppl 1

Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure.
pmid: 18635526
abstract: The inhibitor of apoptosis protein survivin is selectively expressed in tumor cells. The tobacco component nicotine increases the transcription of the survivin gene in non-small cell lung cancer cells. However, the role of survivin expression induced by tobacco component is not clear during lung carcinogenesis. We investigated the effects of the tobacco components nicotine and its related carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on survivin expression in normal human bronchial epithelial (NHBE) cells and examined the role of survivin in the malignant transformation of normal human bronchial epithelial (HBE) cells induced by these components. We found that survivin messenger RNA (mRNA) expression was detected in 41% (7 of 17) of bronchial brush specimens from heavy smokers. Nicotine and NNK increased survivin mRNA and protein expression levels in primary cultured NHBE cells and immortalized HBE cells. Bronchial epithelium in mice administered NNK also showed increased staining for survivin. Nicotine and NNK stimulated the Akt-mammalian target of rapamycin (mTOR) pathway in NHBE cells, leading to increased de novo synthesis of survivin protein. Induced survivin expression increased the survival potential of the cells, which was blocked by transfection with survivin-specific small interfering RNA (siRNA). siRNA-induced down-regulation of survivin expression also suppressed the tumorigenic potential of premalignant and malignant HBE cells exposed to the tobacco components. These findings suggest that NNK and nicotine induce survivin protein synthesis in NHBE cells by activating the Akt-mTOR pathway and thus blockade of the pathway effectively inhibits the tobacco-induced malignant transformation of HBE cells.
has PII: bgm234
doi: 10.1093/carcin/bgm234
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Jin Q
      type: Person
      first name: Quanri
      last name: Jin
      member of: Department of Thoracic/Head and Neck Medical Oncology, Unit 432, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
  slot:
    index: 2
    item: Menter DG
      type: Person
      first name: David G
      last name: Menter
  slot:
    index: 3
    item: Mao L
      type: Person
      first name: Li
      last name: Mao
  slot:
    index: 4
    item: Hong WK
      type: Person
      first name: Waun Ki
      last name: Hong
  slot:
    index: 5
    item: Lee HY
      type: Person
      first name: Ho-Young
      last name: Lee
created: 2008-7-19T09:00
date last updated: 2025-01-17
issued: 2008-08
dp: 2008 Aug
e ISSN: 1460-2180
has issn l: 0143-3334
issue: 8
has NLM journal title abbreviation: Carcinogenesis
publication name: Carcinogenesis
language: eng
has national library of medicine journal id: 8008055
derived from: NLM
starting page: 1614
ending page: 22
has place of publication: England
has primary subject term: D001980Q000166Q000502
has primary subject term: D001984Q000209Q000235Q000473
has primary subject term: D004847Q000502
has primary subject term: D005786
has primary subject term: D008175Q000209Q000235Q000473
has primary subject term: D008869Q000235
has primary subject term: D009363Q000235
has subject term: D006801
has subject term: D017209
has subject term: D002453
has subject term: D002460
has subject term: D002470
has subject term: D004273Q000235
has subject term: D015972
has subject term: D051034
has subject term: D009154
has subject term: D011230Q000235
has subject term: D020133
has subject term: D012334Q000235
has subject term: D034741Q000235
has subject term: http://id.nlm.nih.gov/mesh/D000077022
has subject term: D009538
source: Carcinogenesis. 2008-08;29(8):1614-22.
volume: 29

Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
pmid: 17307803
abstract: Oral cancer is the leading cancer type among Southeast Asian men and is causally associated with the use of tobacco. Genetic polymorphisms in xenobiotic-metabolizing enzymes modify the effect of environmental exposures, thereby playing a significant role in gene-environment interactions and hence contribute to the high degree of variance in individual susceptibility to cancer risk. This study investigates the role of polymorphisms at CYP1A1, GSTM1 and GSTT1 to oral squamous cell carcinoma (OSCC) in a case-control study involving 155 patients with precancerous lesions, 458 cancer patients and 729 age and habit-matched controls. Genotypes at these loci were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism performed on genomic DNA extracted from peripheral blood lymphocytes. Risk to oral cancer was estimated among different tobacco exposure groups and doses using logistic regression analysis. GSTM1 null genotype conferred 1.29-fold increased risk [95% confidence interval (CI), 1.04-1.65] to OSCC. GSTT1 null genotype, however, conferred 0.57 times reduced risk to OSCC (95% CI, 0.39-0.83), specifically among tobacco chewers (odds ratio 0.27; 95% CI, 0.14-0.53). This risk was further reduced to 0.13 times (95% CI, 0.04-0.46) with increase in lifetime exposure to tobacco. We also investigated risk conferred by these genotypes at two different intra-oral sites, buccal mucosa and tongue. We found increased susceptibility to buccal mucosa cancer among individuals carrying these genetic markers. These results support the finding that GSTM1 null genotype is a risk factor to OSCC among Indian tobacco habits; GSTT1 null genotype, however, emerged as a protective factor.
has PII: bgm038
doi: 10.1093/carcin/bgm038
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Anantharaman D
      type: Person
      first name: Devasena
      last name: Anantharaman
      member of: Cancer Research Institute, Advanced Center for Treatment, Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai 410 208, India.
  slot:
    index: 2
    item: Chaubal PM
      type: Person
      first name: Pranay M
      last name: Chaubal
  slot:
    index: 3
    item: Kannan S
      type: Person
      first name: Sadhana
      last name: Kannan
  slot:
    index: 4
    item: Bhisey RA
      type: Person
      first name: Rajani A
      last name: Bhisey
  slot:
    index: 5
    item: Mahimkar MB
      type: Person
      first name: Manoj B
      last name: Mahimkar
created: 2007-2-20T09:00
date last updated: 2025-01-17
issued: 2007-07
dp: 2007 Jul
ISSN: 0143-3334
has issn l: 0143-3334
issue: 7
has NLM journal title abbreviation: Carcinogenesis
publication name: Carcinogenesis
language: eng
has national library of medicine journal id: 8008055
derived from: NLM
starting page: 1455
ending page: 62
has place of publication: England
has primary subject term: D002294Q000453Q000235
has primary subject term: D019363Q000235
has primary subject term: D005982Q000235
has primary subject term: D009062Q000453Q000235
has primary subject term: D011110
has subject term: D000293
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D016022
has subject term: D005260
has subject term: D005787
has subject term: D020022
has subject term: D006801
has subject term: D015994
has subject term: D007194Q000453
has subject term: D008297
has subject term: D008875
has subject term: D014029Q000150
source: Carcinogenesis. 2007-07;28(7):1455-62.
volume: 28

Folate-related genes and the risk of tobacco-related cancers in Central Europe.
pmid: 17389614
abstract: Folate has been hypothesized to protect against aero-digestive cancers although the evidence is not yet conclusive due to possible confounding by other dietary factors. Sequence variants in folate pathway were suggested to be associated with plasma folate levels and are unlikely to be confounded by other lifestyle factors. We therefore investigated the effects of key folate genetic variants on the risk of aero-digestive cancers and their potential effect modification by folate intake in a multicenter study in Central Europe. A total of 2250 lung cases, 811 upper aero-digestive tract cases and 2899 controls were recruited with blood samples. The methylenetetrahydrofolate reductase (MTHFR) C677T variant was associated with an increased risk of lung cancer with an odds ratio (OR) for homozygote variant of 1.37 [95% confidence interval (CI) = 1.10-1.71]. The two MTHFR variants were in strong linkage disequilibrium, and 677T-1298A appeared to be the primary haplotype associated with cancer risk. The risk estimates for MTHFR 677T/677T genotype was more prominent among lung cancer patients with young onset (OR = 1.92, 95% CI = 1.12-3.29). When stratified by dietary intake of folate, the effect of the MTHFR 677T variant was more prominent among subjects with low intake of folate: the ORs for 677T/677T genotype among subjects with the lowest decile were 2.60 (95% CI = 1.39-4.88) and 4.14 (95% CI = 1.47-11.7) for lung and upper aero-digestive tract cancer, respectively. In conclusion, we identified a moderate effect of MTHFR C677T on lung cancer risk and a possible effect modification by folate intake that is consistent with the functional data. These results support an important role of folate in protecting against tobacco-related cancers.
has PII: bgm067
doi: 10.1093/carcin/bgm067
creator: OrderedList
  length: 19
  slot:
    index: 1
    item: Hung RJ
      type: Person
      first name: Rayjean J
      last name: Hung
      member of: International Agency for Research on Cancer, 150 cours Albert Thomas, F-69372, 69008, Lyon Cedex 08, France. hung@iarc.fr
  slot:
    index: 2
    item: Hashibe M
      type: Person
      first name: Mia
      last name: Hashibe
  slot:
    index: 3
    item: McKay J
      type: Person
      first name: James
      last name: McKay
  slot:
    index: 4
    item: Gaborieau V
      type: Person
      first name: Valerie
      last name: Gaborieau
  slot:
    index: 5
    item: Szeszenia-Dabrowska N
      type: Person
      first name: Neonila
      last name: Szeszenia-Dabrowska
  slot:
    index: 6
    item: Zaridze D
      type: Person
      first name: David
      last name: Zaridze
  slot:
    index: 7
    item: Lissowska J
      type: Person
      first name: Jolanta
      last name: Lissowska
  slot:
    index: 8
    item: Rudnai P
      type: Person
      first name: Peter
      last name: Rudnai
  slot:
    index: 9
    item: Fabianova E
      type: Person
      first name: Eleonora
      last name: Fabianova
  slot:
    index: 10
    item: Mates I
      type: Person
      first name: Ioan
      last name: Mates
  slot:
    index: 11
    item: Foretova L
      type: Person
      first name: Lenka
      last name: Foretova
  slot:
    index: 12
    item: Janout V
      type: Person
      first name: Vladimir
      last name: Janout
  slot:
    index: 13
    item: Bencko V
      type: Person
      first name: Vladimir
      last name: Bencko
  slot:
    index: 14
    item: Chabrier A
      type: Person
      first name: Amelie
      last name: Chabrier
  slot:
    index: 15
    item: Moullan N
      type: Person
      first name: Norman
      last name: Moullan
  slot:
    index: 16
    item: Canzian F
      type: Person
      first name: Federico
      last name: Canzian
  slot:
    index: 17
    item: Hall J
      type: Person
      first name: Janet
      last name: Hall
  slot:
    index: 18
    item: Boffetta P
      type: Person
      first name: Paolo
      last name: Boffetta
  slot:
    index: 19
    item: Brennan P
      type: Person
      first name: Paul
      last name: Brennan
created: 2007-3-29T09:00
date last updated: 2025-01-17
issued: 2007-06
dp: 2007 Jun
ISSN: 0143-3334
has issn l: 0143-3334
issue: 6
has NLM journal title abbreviation: Carcinogenesis
publication name: Carcinogenesis
language: eng
has national library of medicine journal id: 8008055
derived from: NLM
starting page: 1334
ending page: 40
has place of publication: England
has primary subject term: D005492Q000008Q000235
has primary subject term: D020022
has primary subject term: D009369Q000201Q000235Q000378
has subject term: D013766Q000235
has subject term: D016022
has subject term: D005060
has subject term: D006801
has subject term: D042965Q000235
has subject term: D020641
has subject term: D012307
source: Carcinogenesis. 2007-06;28(6):1334-40.
volume: 28

Nutritional optic neuropathies.
pmid: 17707410
abstract: Nutritional deficiency may be the cause of a genuine optic neuropathy, sometimes associated with involvement of the peripheral nervous system. Nutritional optic neuropathies are usually bilateral, painless, chronic, insidious and slowly progressive. Most often, they present as a non-specific retrobulbar optic neuropathy. The differential diagnosis with other causes of optic nerve involvement, in particular of toxic origin, may be particularly difficult. Nutritional deficits are often associated with toxic effects from alcohol and tobacco; therefore, the separation of the nutritional and toxic components is often illusory and artificial. The pathophysiological mechanisms involved in nutritional -- and toxic -- optic neuropathies affect biochemical pathways involved in cell energetic production, correction of oxidative stress and quenching of free radicals. The recognition of these mechanisms could provide future therapeutic alternatives. Currently, the treatment is limited to the intensive use of vitamins with variable results in individual cases, and to the implementation of preventive measures, when feasible.
has PII: S0022-510X(07)00459-5
doi: 10.1016/j.jns.2007.06.038
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Orssaud C
      type: Person
      first name: C
      last name: Orssaud
      member of: Department of Ophthalmology, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, 20, Rue Leblanc, 75015, Paris, France. christophe.orssaud@hop.egp.ap-hop-paris.fr
  slot:
    index: 2
    item: Roche O
      type: Person
      first name: O
      last name: Roche
  slot:
    index: 3
    item: Dufier JL
      type: Person
      first name: J L
      last name: Dufier
created: 2007-8-21T09:00
date last updated: 2025-01-17
issued: 2007-11-15
dp: 2007 Nov 15
ISSN: 0022-510X
has issn l: 0022-510X
issue: 1-2
has NLM journal title abbreviation: J Neurol Sci
publication name: Journal of the neurological sciences
language: eng
has national library of medicine journal id: 0375403
derived from: NLM
starting page: 158
ending page: 64
has place of publication: Netherlands
has primary subject term: D044342Q000150Q000378Q000503
has primary subject term: D020258Q000175Q000209Q000378
has primary subject term: D009901Q000175Q000209Q000378
has subject term: D003937
has subject term: D004734Q000187Q000502
has subject term: D000431Q000633
has subject term: D006801
has subject term: D009900Q000187Q000378Q000503
has subject term: D018384Q000187Q000502
source: J Neurol Sci. 2007-11-15;262(1-2):158-64.
volume: 262

The effect of maras powder on DNA methylation and micronucleus formation in human buccal tissue.
pmid: 18246499
abstract: The plant powder maras powder (MP) has been used widely instead of cigarettes in the southeastern region of Turkey. The aim of this study was to assess the impacts of MP and cigarette smoking on the methylation and micronuclei (MN) formation in buccal cells of humans with a comparison to blood lymphocytes. DNA samples from 80 subjects (40 MP users, 20 tobacco smokers, 20 healthy volunteers) were analyzed for their genomic methylation status using Hpa II and Msp I digestions followed by a simple gel electrophoresis and ethidium bromide staining. A densitometric method was developed to measure the methylation in genomic DNA samples and the results were evaluated using a software program designed for this purpose. Buccal epithelial cells were collected from the same groups and examined for MN formation. The results indicated that a general genomic hypomethylation was present in almost all of the samples that were obtained from MP users and tobacco smokers. This hypomethylation was significant in MP users compared to smokers and healthy volunteers. The percentage of cells containing MN was 1.93 in MP users, 0.95 in healthy volunteers, and 1.82 in smokers. The MN frequency was significantly higher in MP users and smokers than in healthy volunteers. There was no statistical difference between smokers and MP users. Evidence indicates that MP usage induces DNA hypomethylation and increase frequency of MN formation.
has PII: 790322524
doi: 10.1080/15287390701801661
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Saatci C
      type: Person
      first name: Cetin
      last name: Saatci
      member of: Department of Medical Genetics, Erciyes University Medical Faculty, Kayseri, Turkey. csaatci@erciyes.edu.tr
  slot:
    index: 2
    item: Ozkul Y
      type: Person
      first name: Yusuf
      last name: Ozkul
  slot:
    index: 3
    item: Tahiri S
      type: Person
      first name: Serpil
      last name: Tahiri
  slot:
    index: 4
    item: Caglayan AO
      type: Person
      first name: Ahmet Okay
      last name: Caglayan
  slot:
    index: 5
    item: Turhan AB
      type: Person
      first name: Ahmet Bulent
      last name: Turhan
  slot:
    index: 6
    item: Dundar M
      type: Person
      first name: Munis
      last name: Dundar
created: 2008-2-5T09:00
date last updated: 2025-01-17
issued: 2008
dp: 2008
ISSN: 1528-7394
has issn l: 0098-4108
issue: 6
has NLM journal title abbreviation: J Toxicol Environ Health A
publication name: Journal of toxicology and environmental health. Part A
language: eng
has national library of medicine journal id: 100960995
derived from: NLM
starting page: 396
ending page: 404
has place of publication: England
has primary subject term: D019175Q000187
has primary subject term: D048629Q000187
has primary subject term: D009061Q000166Q000187
has primary subject term: D014030Q000633
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D006801
has subject term: D008875
has subject term: D004247Q000737
has subject term: D004847Q000187
has subject term: D011208
has subject term: D012907Q000009
source: J Toxicol Environ Health A. 2008;71(6):396-404.
volume: 71

Urinary tobacco alkaloid measurement in patients having thromboangiitis obliterans.
pmid: 18828981
has PII: S0025-6196(11)60629-0
doi: 10.4065/83.10.1187-b
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Hurt RD
      type: Person
      first name: Richard D
      last name: Hurt
  slot:
    index: 2
    item: Hays JT
      type: Person
      first name: J Taylor
      last name: Hays
created: 2008-10-3T09:00
date last updated: 2025-01-17
issued: 2008-10
dp: 2008 Oct
e ISSN: 1942-5546
has issn l: 0025-6196
issue: 10
has NLM journal title abbreviation: Mayo Clin Proc
publication name: Mayo Clinic proceedings
language: eng
has national library of medicine journal id: 0405543
derived from: NLM
pg: 1187-8; author reply 1188
has place of publication: England
has primary subject term: D000470Q000652
has primary subject term: D015415Q000652
has primary subject term: D013919Q000209Q000652
has subject term: D000328
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D012907Q000009Q000652
source: Mayo Clin Proc. 2008-10;83(10):1187-8; author reply 1188.
volume: 83

Youth tobacco sales in a metropolitan county: factors associated with compliance.
pmid: 17673095
abstract: To describe and identify factors associated with tobacco sales in a metropolitan county.King County, Washington is the largest county in Washington State with an estimated population of 1.8 million or about 30% of the state's population.The data analysis is based on compliance checks in King County between January 2001 and March 2005. The 8879 checks were conducted by 91 youth operatives aged 14-17. Analysis of data was completed in 2006.The outcome variable for this analysis was whether a sale was made to a youth operative during a compliance check. Associations between independent variables and the outcome variable were examined using 2 x 2 tables, univariate (unadjusted) logistic regression, and multivariate (adjusted) logistic regression analysis.Overall tobacco sales during the 4-year and 3-month period was 7.7%. Convenience stores selling gas were significantly more likely to sell tobacco products to minors, whereas restaurants, bars, and tobacco discount stores were less likely to sell to minors. Other factors that were significantly associated with sales are described.In a county that has adopted many of the required youth access laws, opportunities still exist to reduce sales of tobacco products to minors. Asking for age and photo identification still appears to be an effective strategy in reducing sales of tobacco products to minors.
has PII: S0749-3797(07)00233-4
doi: 10.1016/j.amepre.2007.04.010
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pearson DC
      type: Person
      first name: Dave C
      last name: Pearson
      member of: Angulo-Group Health Community Foundation, Seattle, Washington 98012, USA. pearson.d@ghc.org
  slot:
    index: 2
    item: Song L
      type: Person
      first name: Lin
      last name: Song
  slot:
    index: 3
    item: Valdez RB
      type: Person
      first name: Roger B
      last name: Valdez
  slot:
    index: 4
    item: Angulo AS
      type: Person
      first name: Antoinette S
      last name: Angulo
created: 2007-8-4T09:00
date last updated: 2025-01-17
issued: 2007-08
dp: 2007 Aug
ISSN: 0749-3797
has issn l: 0749-3797
issue: 2
has NLM journal title abbreviation: Am J Prev Med
publication name: American journal of preventive medicine
language: eng
has national library of medicine journal id: 8704773
derived from: NLM
starting page: 91
ending page: 7
has place of publication: Netherlands
has primary subject term: D002669Q000331
has primary subject term: D003132Q000191Q000331
has primary subject term: D035846
has primary subject term: D019460Q000191Q000331
has subject term: D000293
has subject term: D000328
has subject term: D000367
has subject term: D002648
has subject term: D005260
has subject term: D006293
has subject term: D006801
has subject term: D008297
has subject term: D015397
has subject term: D014861
source: Am J Prev Med. 2007-08;33(2):91-7.
volume: 33

Health and social impacts of tobacco production.
pmid: 19274899
abstract: To summarize current knowledge about the health and social consequences of tobacco production and to outline research needed to better understand these effects.The literature documenting the effects of tobacco production is scattered, and not always published in peer-reviewed sources. We undertook a systematic search using (1) a literature file based on over a decade of research on the health effects of tobacco work, (2) searches of computerized data bases (Medline, Science Citation Index, Agricola), (3) a review of new sources cited in literature uncovered through data base searches, and (4) professional contacts with others working on the effects of tobacco production.The health effects of tobacco production include nicotine poisoning (green tobacco sickness), pesticide exposure, respiratory effects, musculoskeletal and other injuries. Most research has focused on nicotine poisoning. Social effects of tobacco production include social disruption for communities in which tobacco production is declining (unemployment, economic loss), and for communities in which tobacco production is being introduced (loss of local food production and local autonomy).Research is needed on the effects of tobacco work on the health of women and children through exposure to nicotine and pesticides, the effects of chronic nicotine exposure on all tobacco workers, the neurotoxic effects of pesticide exposure and its relationship with mental health, and the effects of growing tobacco on using tobacco. Greater effort is needed to document the social disruption in communities that are economically dependent on tobacco production, particularly those in developing countries.
doi: 10.1300/J096v11n03_08
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Arcury TA
      type: Person
      first name: Thomas A
      last name: Arcury
      member of: Department of Family and Community Medicine, Wake Forest University School of Medicine , Winston-Salem, NC 27157-1084, USA. tarcury@wfubmc.edu
  slot:
    index: 2
    item: Quandt SA
      type: Person
      first name: Sara A
      last name: Quandt
created: 2006-1-1T00:00
date last updated: 2025-01-17
issued: 2006
dp: 2006
created: 2009-3-12T09:00
ISSN: 1059-924X
has issn l: 1059-924X
issue: 3-4
has NLM journal title abbreviation: J Agromedicine
publication name: Journal of agromedicine
language: eng
has national library of medicine journal id: 9421530
derived from: NLM
starting page: 71
ending page: 81
has place of publication: England
has primary subject term: D000382Q000453Q000209
has primary subject term: D000383
has primary subject term: D009538Q000506
has primary subject term: D009784Q000453Q000209
has primary subject term: D010575Q000009
has subject term: D006801
has subject term: D012869
source: J Agromedicine. 2006;11(3-4):71-81.
volume: 11

Illicit tobacco: an international problem with an international solution.
pmid: 19133903
has PII: ADD2407
doi: 10.1111/j.1360-0443.2008.02407.x
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Arnott D
      type: Person
      first name: Deborah
      last name: Arnott
  slot:
    index: 2
    item: McEwen A
      type: Person
      first name: Andy
      last name: McEwen
created: 2009-1-13T09:00
date last updated: 2025-01-17
issued: 2009-01
dp: 2009 Jan
e ISSN: 1360-0443
has issn l: 0965-2140
issue: 1
has NLM journal title abbreviation: Addiction
publication name: Addiction (Abingdon, England)
language: eng
has national library of medicine journal id: 9304118
derived from: NLM
starting page: 155
ending page: 7
has place of publication: England
has primary subject term: D013287Q000331
has primary subject term: D013660Q000331
has primary subject term: D014029Q000517
has subject term: D014943
has subject term: D006801
source: Addiction. 2009-01;104(1):155-7.
volume: 104

A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
pmid: 19330036
abstract: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because these mutations confer resistance to commonly used cytotoxic chemotherapies and targeted agents, effective therapies that target K-Ras are needed. Inhibitors of mTOR such as rapamycin can prevent K-Ras-driven lung tumorigenesis and alter the proportion of cytotoxic and Foxp3+ regulatory T cells, suggesting that lung-associated T cells might be important for tumorigenesis.Lung tumorigenesis was studied in three murine models that depend on mutant K-Ras; a tobacco carcinogen-driven model, a syngeneic inoculation model, and a transgenic model. Splenic and lung-associated T cells were studied using flow cytometry and immunohistochemistry. Foxp3+ cells were depleted using rapamycin, an antibody, or genetic ablation.Exposure of A/J mice to a tobacco carcinogen tripled lung-associated Foxp3+ cells prior to tumor development. At clinically relevant concentrations, rapamycin prevented this induction and reduced lung tumors by 90%. In A/J mice inoculated with lung adenocarcinoma cells resistant to rapamycin, antibody-mediated depletion of Foxp3+ cells reduced lung tumorigenesis by 80%. Likewise, mutant K-Ras transgenic mice lacking Foxp3+ cells developed 75% fewer lung tumors than littermates with Foxp3+ cells.Foxp3+ regulatory T cells are required for K-Ras-mediated lung tumorigenesis in mice. These studies support clinical testing of rapamycin or other agents that target Treg in K-Ras driven human lung cancer.
doi: 10.1371/journal.pone.0005061
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Granville CA
      type: Person
      first name: Courtney A
      last name: Granville
      member of: Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
  slot:
    index: 2
    item: Memmott RM
      type: Person
      first name: Regan M
      last name: Memmott
  slot:
    index: 3
    item: Balogh A
      type: Person
      first name: Andria
      last name: Balogh
  slot:
    index: 4
    item: Mariotti J
      type: Person
      first name: Jacopo
      last name: Mariotti
  slot:
    index: 5
    item: Kawabata S
      type: Person
      first name: Shigeru
      last name: Kawabata
  slot:
    index: 6
    item: Han W
      type: Person
      first name: Wei
      last name: Han
  slot:
    index: 7
    item: Lopiccolo J
      type: Person
      first name: Jaclyn
      last name: Lopiccolo
  slot:
    index: 8
    item: Foley J
      type: Person
      first name: Jason
      last name: Foley
  slot:
    index: 9
    item: Liewehr DJ
      type: Person
      first name: David J
      last name: Liewehr
  slot:
    index: 10
    item: Steinberg SM
      type: Person
      first name: Seth M
      last name: Steinberg
  slot:
    index: 11
    item: Fowler DH
      type: Person
      first name: Daniel H
      last name: Fowler
  slot:
    index: 12
    item: Hollander MC
      type: Person
      first name: M Christine
      last name: Hollander
  slot:
    index: 13
    item: Dennis PA
      type: Person
      first name: Phillip A
      last name: Dennis
created: 2009-3-31T09:00
date last updated: 2025-01-17
issued: 2009
dp: 2009
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 3
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e5061
has place of publication: United States
has primary subject term: D011905Q000235
has primary subject term: D008175Q000209
has primary subject term: D009154
has primary subject term: D050378Q000187Q000473
has subject term: D000818
has subject term: D004195
has subject term: D051858
has subject term: D051379
has subject term: D008822
has subject term: D020123Q000494
source: PLoS One. 2009;4(3):e5061.
volume: 4

[Polonium: the radioactive killer from tobacco smoke].
pmid: 19186689
abstract: Among all carcinogenic substances contained in tobacco smoke, Polonium 210 (Po-210), with a half-life of 138 days, is one of the most dangerous, by exerting a devastating, chronic, slow and progressive carcinogenesis activity. The main source of Po-210 in tobacco is represented by fertilizers (polyphosphates) containing radium-226 (Ra-222) which decades to plumb 210 (Pb-210). Through the thricomes Pb-210 is concentrated in the tobacco leaves, where it turns to Po-210, which at the cigarette combustion temperature (800-900 degrees C) reaches the gaseous state and it is absorbed by the micro particles released into tobacco smoke. Thus, smoke becomes radioactive in both its gaseous and corpuscular components and reaches the airways, where, particularly at the branches level and together with other substances, it exerts its carcinogenic activity, especially in those subjects with impaired respiratory mucosal clearance. The carcinogenic risk/one year lifetime of a smoker of 20 cigarettes per day is equivalent to that of undertaking 300 chest x-rays. It is calculated that Po-210 may be independently responsible of 4 lung cancers every 10,000 smokers. During cigarette's combustion, tobacco smoke is also released in the air, contributing to serious health risks for those exposed to passive smoke.
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Zagà V
      type: Person
      first name: Vincenzo
      last name: Zagà
      member of: AUSL di Bologna, Italia. vincenzo.zaga@ausl.bo.it
  slot:
    index: 2
    item: Gattavecchia E
      type: Person
      first name: Enrico
      last name: Gattavecchia
created: 2009-2-4T09:00
date last updated: 2025-01-17
ISSN: 2067-2993
has issn l: 2067-2993
issue: 4
has NLM journal title abbreviation: Pneumologia
publication name: Pneumologia (Bucharest, Romania)
language: rum
has national library of medicine journal id: 100941067
derived from: NLM
starting page: 249
ending page: 54
has place of publication: Romania
has primary subject term: D011059Q000009Q000032
has primary subject term: D012907Q000009
has subject term: D006801
has subject term: D008175Q000209Q000517
has subject term: D011122Q000032
has subject term: D011874
has subject term: D016540
has subject term: D014028Q000009Q000032
source: Pneumologia. ;57(4):249-54.
volume: 57

Canadian Ophthalmological Society evidence-based clinical practice guidelines for the management of glaucoma in the adult eye.
pmid: 19492005
has PII: S0008418209800367
doi: 10.3129/cjo44s1
creator: Canadian Ophthalmological Society Glaucoma Clinical Practice Guideline Expert CommitteeCanadian Ophthalmological Society
created: 2009-6-6T09:00
date last updated: 2025-01-17
issued: 2009
dp: 2009
created: 2009-6-4T09:00
contributor: OrderedList
  length: 9
  slot:
    index: 1
    item: Rafuse PE
      type: Person
      first name: Paul E
      last name: Rafuse
  slot:
    index: 2
    item: Buys YM
      type: Person
      first name: Yvonne M
      last name: Buys
  slot:
    index: 3
    item: Damji KF
      type: Person
      first name: Karim F
      last name: Damji
  slot:
    index: 4
    item: Harasymowycz P
      type: Person
      first name: Paul
      last name: Harasymowycz
  slot:
    index: 5
    item: Lajoie C
      type: Person
      first name: Caroline
      last name: Lajoie
  slot:
    index: 6
    item: Mikelberg FS
      type: Person
      first name: Frederick S
      last name: Mikelberg
  slot:
    index: 7
    item: Murphy PH
      type: Person
      first name: Paul H
      last name: Murphy
  slot:
    index: 8
    item: Nicolela M
      type: Person
      first name: Marcelo
      last name: Nicolela
  slot:
    index: 9
    item: Tingey DP
      type: Person
      first name: David P
      last name: Tingey
e ISSN: 1715-3360
has issn l: 0008-4182
has NLM journal title abbreviation: Can J Ophthalmol
publication name: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
language: engfre
has national library of medicine journal id: 0045312
derived from: NLM
starting page: S7
ending page: 93
has place of publication: England
has primary subject term: D019317
has primary subject term: D005123
has primary subject term: D005901Q000175Q000628
has primary subject term: D009885Q000592
has subject term: D000328
has subject term: D002170
has subject term: D006801
source: Can J Ophthalmol. 2009;44 Suppl 1():S7-93.
volume: 44 Suppl 1

[Contribution to the history of tobacco use].
pmid: 19580122
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kapronczay K
      type: Person
      first name: Károly
      last name: Kapronczay
      member of: Semmelweis Museum, Library and Archives for the History of Medicine, Budapest, Hungary. orvostortenet@t-online.hu
created: 2008-1-1T00:00
date last updated: 2025-01-17
issued: 2008
dp: 2008
created: 2009-7-8T09:00
ISSN: 0010-3551
has issn l: 0010-3551
issue: 1-4
has NLM journal title abbreviation: Orvostort Kozl
publication name: Orvostorteneti kozlemenyek
language: hun
has national library of medicine journal id: 0435507
derived from: NLM
starting page: 93
ending page: 103
has place of publication: Hungary
has primary subject term: D009538Q000009Q000266
has primary subject term: D014029Q000266
has subject term: D000569
has subject term: D005060
has subject term: D006076Q000266
has subject term: D049668
has subject term: D049669
has subject term: D049670
has subject term: D049671
has subject term: D049672
has subject term: D006801
has subject term: D006814
has subject term: D007198Q000266
has subject term: D018722Q000266
has subject term: D011640
has subject term: D016540Q000266
has subject term: D013660
source: Orvostort Kozl. 2008;54(1-4):93-103.
volume: 54

Characterization of Canadian cigarettes using multi-stable isotope analysis by gas chromatography-isotope ratio mass spectrometry.
pmid: 19187017
abstract: A reliable method for measuring (15)N/(14)N and (2)H/(1)H ratios of nicotine in cigarette tobacco has been developed. It involves a simple procedure for extracting nicotine from tobacco using methanol. The extract is directly analyzed on a gas chromatography isotope ratio mass spectrometer (GC-IRMS). The method is reproducible with 4% RSD for delta(2)H and delta(15)N. Brand name cigarettes manufactured in Canada (N = 47) and in China (N = 23) have been analyzed. The results show that nicotine from Canadian cigarettes has a higher (2)H/(1)H ratio and a lower (15)N/(14)N ratio than the Chinese cigarettes. The delta(2)H values for Canadian cigarettes range from -232.7 per thousand to -203.4 per thousand with an average of -222.1 per thousand; the delta(2)H values for Chinese cigarettes range from -262.6 per thousand to -219.9 per thousand with an average of -243.8 per thousand. The delta(15)N values for Canadian cigarettes range from -7.7 per thousand to -6.3 per thousand with an average of -7.1 per thousand; the delta(15)N values for Chinese cigarettes range from -7.6 per thousand to -5.7 per thousand with an average of -6.3 per thousand. The combined measurements of (2)H/(1)H and (15)N/(14)N have been shown to be useful in identifying counterfeits of Canadian cigarettes analyzed in this study.
has PII: 10.1021/jf802642d
doi: 10.1021/jf802642d
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Binette MJ
      type: Person
      first name: Marie-Josée
      last name: Binette
      member of: Laboratory and Scientific Services Directorate, Canada Border and Services Agency, 79 Bentley Avenue, Ottawa, Ontario K2E 6T7, Canada. Marie-Josee.Binette@cbsa-asfc.gc.ca
  slot:
    index: 2
    item: Lafontaine P
      type: Person
      first name: Pierre
      last name: Lafontaine
  slot:
    index: 3
    item: Vanier M
      type: Person
      first name: Micheline
      last name: Vanier
  slot:
    index: 4
    item: Ng LK
      type: Person
      first name: Lay-Keow
      last name: Ng
created: 2009-2-4T09:00
date last updated: 2025-01-17
issued: 2009-02-25
dp: 2009 Feb 25
e ISSN: 1520-5118
has issn l: 0021-8561
issue: 4
has NLM journal title abbreviation: J Agric Food Chem
publication name: Journal of agricultural and food chemistry
language: eng
has national library of medicine journal id: 0374755
derived from: NLM
starting page: 1151
ending page: 5
has place of publication: United States
has primary subject term: D008401
has primary subject term: D007554Q000032
has subject term: D002170
has subject term: D002681
has subject term: D003903Q000032
has subject term: D006859Q000032
has subject term: D009538Q000737Q000302
has subject term: D009584Q000032
has subject term: D009587Q000032
has subject term: D012907
source: J Agric Food Chem. 2009-02-25;57(4):1151-5.
volume: 57

Public health. Expanded U.S. drug agency to control tobacco.
pmid: 19541959
has PII: 324/5934/1497
doi: 10.1126/science.324_1497
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Couzin-Frankel J
      type: Person
      first name: Jennifer
      last name: Couzin-Frankel
  slot:
    index: 2
    item: Koenig R
      type: Person
      first name: Robert
      last name: Koenig
created: 2009-6-23T09:00
date last updated: 2025-01-17
issued: 2009-06-19
dp: 2009 Jun 19
e ISSN: 1095-9203
has issn l: 0036-8075
issue: 5934
has NLM journal title abbreviation: Science
publication name: Science (New York, N.Y.)
language: eng
has national library of medicine journal id: 0404511
derived from: NLM
pg: 1497
has place of publication: United States
has primary subject term: D014486
has subject term: D019460
has subject term: D014481
source: Science. 2009-06-19;324(5934):1497.
volume: 324

Harms associated with psychoactive substances: findings of the UK National Drug Survey.
pmid: 19939875
abstract: Nutt and colleagues' 'rational' scale to assess the harms of commonly used drugs was based on ratings by a panel of experts. This survey aimed to assess drug users' views of the harms of drugs using the same scale. As users' drug choices are not solely based on harms, we additionally assessed perceived benefits. The survey was hosted at http://www.nationaldrugsurvey.org. UK residents reported their experience of 20 commonly used substances; those with direct experience of a substance rated its physical, dependence-related and social harms as well as benefits. A total of 1501 users completed the survey. There was no correlation between the classification of the 20 drugs under the Misuse of Drugs Act and ranking of harms by users. Despite being unclassified substances, alcohol, solvents and tobacco were rated within the top ten most harmful drugs. There was a remarkably high correlation (r = 0.896) overall between rankings by users' and by experts. Ecstasy, cannabis and LSD were ranked highest by users on both acute and chronic benefits. These findings imply that users are relatively well informed about the harms associated with the drugs they use. They also suggest that the current UK legal classification system is not acting to inform users of the harms of psychoactive substances.
has PII: 0269881109106915
doi: 10.1177/0269881109106915
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Morgan CJ
      type: Person
      first name: Celia J A
      last name: Morgan
      member of: Clinical Psychopharmacology Unit, University College London, London, UK. c.morgan@ucl.ac.uk
  slot:
    index: 2
    item: Muetzelfeldt L
      type: Person
      first name: Leslie
      last name: Muetzelfeldt
  slot:
    index: 3
    item: Muetzelfeldt M
      type: Person
      first name: Mark
      last name: Muetzelfeldt
  slot:
    index: 4
    item: Nutt DJ
      type: Person
      first name: David J
      last name: Nutt
  slot:
    index: 5
    item: Curran HV
      type: Person
      first name: H Valerie
      last name: Curran
created: 2009-11-27T06:00
date last updated: 2025-01-17
issued: 2010-02
dp: 2010 Feb
e ISSN: 1461-7285
has issn l: 0269-8811
issue: 2
has NLM journal title abbreviation: J Psychopharmacol
publication name: Journal of psychopharmacology (Oxford, England)
language: eng
has national library of medicine journal id: 8907828
derived from: NLM
starting page: 147
ending page: 53
has place of publication: United States
has primary subject term: D013287Q000633
has primary subject term: D011619Q000633
has primary subject term: D019966Q000150Q000523
has subject term: D000293
has subject term: D000328
has subject term: D000428Q000009
has subject term: D003625
has subject term: D005260
has subject term: D007722
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D018570
has subject term: D012940Q000523
has subject term: D012997Q000633
has subject term: D006113
has subject term: D055815
source: J Psychopharmacol. 2010-02;24(2):147-53.
volume: 24

Tobacco carcinogen induces microglial activation and subsequent neuronal damage.
pmid: 19500213
abstract: 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific procarcinogen. We have investigated whether NNK causes inflammatory upheaval in the brain by activation of resident microglia and astrocyte and result in bystander neuronal damage. We have carried out the work in both in vitro and in vivo models. We have found that treatment with NNK causes significant activation of mouse microglial (BV2) cell line as evident by increase in reactive oxygen species and nitric oxide level. Western blot analysis has showed increase in proinflammatory signaling proteins, proinflammatory effector proteins, and other stress-related proteins. Interestingly, increased levels of proinflammatory cytokines like interleukin (IL)-6, tumor necrosis factor-alpha, monocyte chemoattractant protein 1 (MCP1), and IL-12p70 are also detected. Work from our in vivo studies has demonstrated similar increase in proinflammatory signaling and effector molecules along with the proinflammatory cytokine levels, following NNK treatment. Immunohistochemical staining of the brain sections of NNK-treated mice reveals massive microglial and astrocyte activation along with distinct foci of neuronal damage. Both in vitro and in vivo results provide strong indication that NNK causes significant upheaval of the inflammatory condition of brain and inflicts subsequent neuronal damage.
has PII: JNC6203
doi: 10.1111/j.1471-4159.2009.06203.x
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ghosh D
      type: Person
      first name: Debapriya
      last name: Ghosh
      member of: National Brain Research Centre, Manesar, Haryana, India.
  slot:
    index: 2
    item: Mishra MK
      type: Person
      first name: Manoj Kumar
      last name: Mishra
  slot:
    index: 3
    item: Das S
      type: Person
      first name: Sulagna
      last name: Das
  slot:
    index: 4
    item: Kaushik DK
      type: Person
      first name: Deepak Kumar
      last name: Kaushik
  slot:
    index: 5
    item: Basu A
      type: Person
      first name: Anirban
      last name: Basu
created: 2009-6-9T09:00
date last updated: 2025-01-17
issued: 2009-08
dp: 2009 Aug
e ISSN: 1471-4159
has issn l: 0022-3042
issue: 3
has NLM journal title abbreviation: J Neurochem
publication name: Journal of neurochemistry
language: eng
has national library of medicine journal id: 2985190R
derived from: NLM
starting page: 1070
ending page: 81
has place of publication: England
has primary subject term: D002273Q000633
has primary subject term: D017628Q000187Q000378Q000473
has primary subject term: D009474Q000187Q000378Q000473
has subject term: D000818
has subject term: D002460
has subject term: D045744
has subject term: D005260
has subject term: D008297
has subject term: D051379
has subject term: D008807
has subject term: D009602Q000633
source: J Neurochem. 2009-08;110(3):1070-81.
volume: 110

Ranking the harm of alcohol, tobacco and illicit drugs for the individual and the population.
pmid: 20606445
abstract: Drug policy makers continuously face a changing pattern of drug use, i.e. new drugs appear on the market, the popularity of certain drugs changes or drugs are used in another way or another combination. For legislative purposes, drugs have mostly been classified according to their addictive potency. Such classifications, however, lack a scientific basis. The present study describes the results of a risk assessment study where 19 recreational drugs (17 illicit drugs plus alcohol and tobacco) used in the Netherlands have been ranked by a Dutch expert panel according to their harm based on the scientific state of the art. The study applies a similar approach as recently applied by Nutt et al. [Lancet 2007;369:1047-1053], so that the results of both studies could be compared. The harm indicators scored are acute and chronic toxicity, addictive potency and social harm. The aim of this study is to evaluate whether the legal classification of drugs in the Netherlands corresponds with the ranking of the drugs according to their science-based ranking of harm. Based on the results, recommendations are formulated about the legal classification of recreational drugs at national and international level which serves a rational approach for drug control.
rights: Copyright © 2010 S. Karger AG, Basel.
has PII: 000317249
doi: 10.1159/000317249
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: van Amsterdam J
      type: Person
      first name: Jan
      last name: van Amsterdam
      member of: Laboratory for Health Protection Research, RIVM, Bilthoven, The Netherlands. jan.van.amsterdam@rivm.nl
  slot:
    index: 2
    item: Opperhuizen A
      type: Person
      first name: Antoon
      last name: Opperhuizen
  slot:
    index: 3
    item: Koeter M
      type: Person
      first name: Maarten
      last name: Koeter
  slot:
    index: 4
    item: van den Brink W
      type: Person
      first name: Wim
      last name: van den Brink
created: 2010-7-8T06:00
date last updated: 2025-01-17
issued: 2010
dp: 2010
e ISSN: 1421-9891
has issn l: 1022-6877
issue: 4
has NLM journal title abbreviation: Eur Addict Res
publication name: European addiction research
language: eng
has national library of medicine journal id: 9502920
derived from: NLM
starting page: 202
ending page: 7
has place of publication: Switzerland
has primary subject term: D004335Q000331
has primary subject term: D000431
has primary subject term: D013287Q000331
has primary subject term: D057766
has subject term: D000428Q000331
has subject term: D006801
has subject term: D009426
has subject term: D011634Q000331
source: Eur Addict Res. 2010;16(4):202-7.
volume: 16

Development of a complicated pain syndrome following cyanide poisoning in a U.S. soldier.
pmid: 20446507
abstract: A majority of modern war wounds are caused by blasts and high-energy ballistics. Extremity injuries predominate since modern body armor does not protect these areas due to mobility limitations. A less known and more insidious mechanism of enemy attack among our soldiers involves treachery by the local populace posing as noncombatants. One such recent event involved the contamination of tobacco with cyanide (CN). We describe a case of a soldier with CN intoxication due to ingestion of tobacco purchased from a local merchant. The soldier developed a complex neuropathic pain syndrome and was successfully treated with an inpatient high-dose intravenous ketamine infusion in combination with continuous peripheral nerve blockade.
doi: 10.7205/milmed-d-09-00127
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lenart M
      type: Person
      first name: Mark
      last name: Lenart
      member of: Army Regional Anaesthesia and Pain Management Initiative, Anaesthesia and Operative Service, Walter Reed Army Medical Center, Building 2, Ward 44, Room 4418, Washington, DC 20307-5001, USA.
  slot:
    index: 2
    item: Buckenmaier CC
      type: Person
      first name: Chester C
      last name: Buckenmaier
  slot:
    index: 3
    item: Kim MJ
      type: Person
      first name: Moon J
      last name: Kim
  slot:
    index: 4
    item: Plunkett AR
      type: Person
      first name: Anthony R
      last name: Plunkett
created: 2010-5-8T06:00
date last updated: 2025-01-17
issued: 2010-04
dp: 2010 Apr
ISSN: 0026-4075
has issn l: 0026-4075
issue: 4
has NLM journal title abbreviation: Mil Med
publication name: Military medicine
language: eng
has national library of medicine journal id: 2984771R
derived from: NLM
starting page: 292
ending page: 4
has place of publication: England
has primary subject term: D000700Q000008
has primary subject term: D020918Q000139Q000188
has primary subject term: D003486Q000506
has primary subject term: D007649Q000008
has primary subject term: D008889
has subject term: D000328
has subject term: D055826
has subject term: D004340
has subject term: D006801
has subject term: D007262
has subject term: D008297
has subject term: D014481
source: Mil Med. 2010-04;175(4):292-4.
volume: 175

Criminalizing knowledge: the perverse implications of the intended use regulations of off-label promotion prosecutions.
pmid: 19999637
abstract: Your company has spent months designing a compliance program and training your sales representatives. They know never to mention the off-label uses of your product. If they are asked about the off-label uses by the physician they are detailing, they know to forward those inquiries to the scientific liaisons at headquarters. But, could your company still be in legal jeopardy simply because it knows that the product is being used for an off-label purpose? This article attempts to track the Food and Drug Administration's (FDA's) shifting interpretation of its intended use regulations, from focusing entirely on the statements of the manufacturers to focusing on the knowledge of the industry, indeed, of the consumers of products, in determining the true intended use of a product. It will look at several recent attempts by FDA to use that new interpretation of the regulations to expand its power: to regulate tobacco and to require pediatric indications for any new drug. Finally, it will look at several recent examples of how this new interpretation has manifested in actions by FDA and the Department of Justice (DOJ).
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Gentry G
      type: Person
      first name: Gregory
      last name: Gentry
      member of: Morrison Mahoney, LLP, Boston, Massachusetts, USA.
created: 2009-12-17T06:00
date last updated: 2025-01-17
issued: 2009
dp: 2009
ISSN: 1064-590X
has issn l: 1064-590X
issue: 3
has NLM journal title abbreviation: Food Drug Law J
publication name: Food and drug law journal
language: eng
has national library of medicine journal id: 9215384
derived from: HSR
starting page: 441
ending page: 58
has place of publication: United States
has primary subject term: D003415Q000331Q000517
has primary subject term: D018795Q000331
has primary subject term: D017277Q000331
has primary subject term: D004348Q000331
has primary subject term: D016365
has primary subject term: D008389Q000331
has primary subject term: D056687Q000266Q000331
has subject term: D005607Q000331Q000517
has subject term: D033161
has subject term: D007722
has subject term: D049673
has subject term: D006801
has subject term: D033182
has subject term: D017387Q000331
has subject term: D010818Q000331
has subject term: D019460Q000331
has subject term: D014481
has subject term: D014486
source: Food Drug Law J. 2009;64(3):441-58.
volume: 64

FDA regulation of tobacco: blessing or curse for FDA professionals?
pmid: 19999639
abstract: Upwards of 400,000 Americans will die that year from the effects of cigarettes, which FDA will now regulate very gently, with its hands tied by a slick statutory protection for the largest existing tobacco marketers. Career FDA professionals will be criticized as enablers of mega-marketers' continued sales, working at the margins, arranging the paperwork for protection of megafirms' market share, and sitting by as the deaths and addictive behaviors continue. Join the Public Health Service, inspired by a public health mission, they were told, and yet they will be unable to do much regulating of the addictive and fatal products for which they now have titular responsibility. This essay observes that these fine FDA professionals are handed the sticky remains of a messy bargain, negotiated in a distracted Congress by expensive lawyers with clients who were potent contributors to political action committees. The only formula that is not secret about the 2009 law is the way in which industry purchased sufficient allegiance to gather the votes for its adoption. The remaining mystery is how FDA could be expected to do these tasks without losing its best and brightest professionals to other fields.
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: O'Reilly JT
      type: Person
      first name: James T
      last name: O'Reilly
      member of: College of Law, University of Cincinnati, Cincinnati, OH, USA.
created: 2009-12-17T06:00
date last updated: 2025-01-17
issued: 2009
dp: 2009
ISSN: 1064-590X
has issn l: 1064-590X
issue: 3
has NLM journal title abbreviation: Food Drug Law J
publication name: Food and drug law journal
language: eng
has national library of medicine journal id: 9215384
derived from: HSR
starting page: 459
ending page: 72
has place of publication: United States
has primary subject term: D033161
has primary subject term: D040541Q000331
has primary subject term: D011356Q000331
has primary subject term: D016540Q000331
has primary subject term: D019460Q000331
has primary subject term: D014486Q000331
has subject term: D000329Q000331
has subject term: D006801
has subject term: D016365
has subject term: D057051Q000331
has subject term: D014481
source: Food Drug Law J. 2009;64(3):459-72.
volume: 64

FDA exercises new authority to regulate tobacco products, but some limits remain.
pmid: 19920227
has PII: 302/19/2078
doi: 10.1001/jama.2009.1632
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Mitka M
      type: Person
      first name: Mike
      last name: Mitka
created: 2009-11-19T06:00
date last updated: 2025-01-17
issued: 2009-11-18
dp: 2009 Nov 18
e ISSN: 1538-3598
has issn l: 0098-7484
issue: 19
has NLM journal title abbreviation: JAMA
publication name: JAMA
language: eng
has national library of medicine journal id: 7501160
derived from: NLM
pg: 2078, 2080-1
has place of publication: United States
has primary subject term: D005421
has primary subject term: http://id.nlm.nih.gov/mesh/D000074606
has primary subject term: D019460Q000331
has subject term: D000329Q000331
has subject term: D006801
has subject term: D008610
has subject term: D011356Q000331
has subject term: D014481
has subject term: D014486
source: JAMA. 2009-11-18;302(19):2078, 2080-1.
volume: 302

Effect of nicotine and tobacco administration method on the mechanical properties of healing bone following closed fracture.
pmid: 20225318
abstract: We previously showed different effects of tobacco and nicotine on fracture healing, but due to pump reservoir limits, maximum exposure period was 4 weeks. To allow flexibility in pre- and post-fracture exposure periods, the objective of this study was to compare a new oral administration route for nicotine to the established pump method. Four groups were studied: (1) pump saline, (2) pump saline + oral tobacco, (3) pump saline/nicotine + oral tobacco, and (4) pump saline + oral nicotine/tobacco. Sprague-Dawley rats (n = 84) received a transverse femoral fracture stabilized with an intramedullary pin 1 week after initiating dosing. After 3 weeks, no difference was found in torsional strength or stiffness between oral nicotine/tobacco or pump nicotine + tobacco, while energy absorption with oral nicotine/tobacco was greater than pump nicotine + tobacco (p < 0.05). Compared to saline control, strength for oral nicotine/tobacco was higher than control (p < 0.05), and stiffnesses for pump nicotine + tobacco and oral nicotine/tobacco were higher than control (p < 0.05). No differences in energy were found for either nicotine-tobacco group compared to saline control. Mean serum cotinine (stable nicotine metabolite) was different between pump and oral nicotine at 1 and 4 weeks, but all groups were in the range of 1-2 pack/day smokers. In summary, relevant serum cotinine levels can be reached in rats with oral nicotine, and, in the presence of tobacco, nicotine can influence mechanical aspects of fracture healing, dependent on administration method. Caution should be exercised when comparing results of fracture healing studies using different methods of nicotine administration.
rights: (c) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
doi: 10.1002/jor.21106
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Hastrup SG
      type: Person
      first name: Sidsel Gaarn
      last name: Hastrup
      member of: Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Norrebrogade 44, Building 1A, 8000 Aarhus C, Denmark. d022340@dadlnet.dk
  slot:
    index: 2
    item: Chen X
      type: Person
      first name: Xinqian
      last name: Chen
  slot:
    index: 3
    item: Bechtold JE
      type: Person
      first name: Joan E
      last name: Bechtold
  slot:
    index: 4
    item: Kyle RF
      type: Person
      first name: Richard F
      last name: Kyle
  slot:
    index: 5
    item: Rahbek O
      type: Person
      first name: Ole
      last name: Rahbek
  slot:
    index: 6
    item: Keyler DE
      type: Person
      first name: Daniel E
      last name: Keyler
  slot:
    index: 7
    item: Skoett M
      type: Person
      first name: Martin
      last name: Skoett
  slot:
    index: 8
    item: Soeballe K
      type: Person
      first name: Kjeld
      last name: Soeballe
created: 2010-3-13T06:00
date last updated: 2025-01-17
issued: 2010-09
dp: 2010 Sep
e ISSN: 1554-527X
has issn l: 0736-0266
issue: 9
has NLM journal title abbreviation: J Orthop Res
publication name: Journal of orthopaedic research : official publication of the Orthopaedic Research Society
language: eng
has national library of medicine journal id: 8404726
derived from: NLM
starting page: 1235
ending page: 9
has place of publication: United States
has primary subject term: D017102Q000187
has primary subject term: D005596Q000000981Q000503
has primary subject term: D009538Q000494
has primary subject term: D010936Q000494
has subject term: D000284
has subject term: D000818
has subject term: D004195
has subject term: D016503
has subject term: D007260
has subject term: D008297
has subject term: D018722Q000494
has subject term: D011859
has subject term: D051381
has subject term: D017207
has subject term: D054159
has subject term: D014867
source: J Orthop Res. 2010-09;28(9):1235-9.
volume: 28

Mr. ATOD's wild ride: what do alcohol, tobacco, and other drugs have in common?
pmid: 20058396
abstract: All researchers agree that individuals can become intoxicated by and dependent on alcohol, tobacco, and other psychoactive drugs. But they have disagreed over whether, and to what extent, drug pathologies comprise a unitary medical problem. Most critically, does addiction have a biological common denominator? Consensus on this question has shifted back and forth. In the late nineteenth and early twentieth centuries, physicians often studied and treated various drug addictions together, working under the inebriety paradigm. By the mid-twentieth century the inebriety paradigm had collapsed. Tobacco and alcohol had split off, both in the medical research community and in western popular culture. This article argues that neuroscientific, genetic, epidemiological, and historical evidence helped to reunify the addiction field in the late twentieth century. A new unifying paradigm emerged, variously called chemical dependency, substance abuse, or simply ATOD -- alcohol, tobacco, and other drugs.
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Courtwright DT
      type: Person
      first name: David T
      last name: Courtwright
      member of: Univ. of North Florida.
created: 2005-10-1T00:00
date last updated: 2025-01-17
issued: 2005
dp: 2005
created: 2010-1-12T06:00
ISSN: 1930-8418
has issn l: 1930-8418
issue: 1
has NLM journal title abbreviation: Soc Hist Alcohol Drugs
publication name: The social history of alcohol and drugs
language: eng
has national library of medicine journal id: 101257917
derived from: HMD
starting page: 105
ending page: 40
has place of publication: United States
has primary subject term: D019973Q000191Q000208Q000266Q000523
has primary subject term: D003466
has primary subject term: D011619Q000191Q000266
has primary subject term: D011634Q000191Q000193Q000266Q000331
has primary subject term: D012106Q000191Q000193Q000266Q000331
has primary subject term: D012941
has primary subject term: D019966Q000191Q000208Q000266Q000523
has subject term: D000434Q000191Q000266
has subject term: D003858
has subject term: D049672
has subject term: D049673
has subject term: D010336Q000193Q000266
has subject term: D010361Q000266Q000331Q000523
has subject term: D010820Q000191Q000266Q000331Q000523
has subject term: D012920Q000191Q000208Q000266Q000523
has subject term: D012946Q000191Q000208Q000266Q000331Q000523
source: Soc Hist Alcohol Drugs. 2005;20(1):105-40.
volume: 20

Single nucleotide polymorphisms in tobacco metabolism and DNA repair genes and prognosis in resected non-small-cell lung cancer.
pmid: 21324488
abstract: If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA repair, and multidrug resistance have been related to lung cancer susceptibility. We examined 13 SNPs in 10 of these genes and correlated the results with time to progression (TTP) and overall survival (OS) in 71 smoker or former smoker patients with resected non-small-cell lung cancer (NSCLC).DNA was obtained from paraffin-embedded tumor. SNP analysis of the candidate genes was performed by allelic discrimination assay. Log-rank test, Kaplan-Meier plots, and Cox multivariate analysis were used to evaluate the association of TTP and survival with the SNPs evaluated.Patients with wild-type (wt) XPC rs2228001, wt CYP2C8 rs10509681, or non-wt NAT2 rs1799930 had a longer TTP. Patients with wt ERCC1 showed a nonsignificant trend towards longer TTP. No other relation between SNPs and TTP were observed. Patients harboring at least two unfavorable genotypes in these four genes had a shorter TTP and OS than patients with either one or no unfavorable genotypes. In the multivariate analysis, non-wt XPC rs2228001 and the presence of at least two unfavorable genotypes emerged as independent markers for shorter TTP.SNPs in tobacco metabolism and DNA repair genes may influence the clinical outcome of resected NSCLC.
rights: Copyright © 2011 Elsevier Inc. All rights reserved.
has PII: S0022-4804(11)00004-7
doi: 10.1016/j.jss.2011.01.007
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Campayo M
      type: Person
      first name: Marc
      last name: Campayo
      member of: Department of Medical Oncology, ICMHO, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
  slot:
    index: 2
    item: Viñolas N
      type: Person
      first name: Nuria
      last name: Viñolas
  slot:
    index: 3
    item: Navarro A
      type: Person
      first name: Alfons
      last name: Navarro
  slot:
    index: 4
    item: Carcereny E
      type: Person
      first name: Enric
      last name: Carcereny
  slot:
    index: 5
    item: Casas F
      type: Person
      first name: Francesc
      last name: Casas
  slot:
    index: 6
    item: Gel B
      type: Person
      first name: Bernat
      last name: Gel
  slot:
    index: 7
    item: Diaz T
      type: Person
      first name: Tania
      last name: Diaz
  slot:
    index: 8
    item: Gimferrer JM
      type: Person
      first name: Josep Maria
      last name: Gimferrer
  slot:
    index: 9
    item: Marrades RM
      type: Person
      first name: Ramon M
      last name: Marrades
  slot:
    index: 10
    item: Ramirez J
      type: Person
      first name: Jose
      last name: Ramirez
  slot:
    index: 11
    item: Monzo M
      type: Person
      first name: Mariano
      last name: Monzo
created: 2011-2-18T06:00
date last updated: 2025-01-17
issued: 2011-05-01
dp: 2011 May 01
e ISSN: 1095-8673
has issn l: 0022-4804
issue: 1
has NLM journal title abbreviation: J Surg Res
publication name: The Journal of surgical research
language: eng
has national library of medicine journal id: 0376340
derived from: NLM
starting page: e5
ending page: 12
has place of publication: United States
has primary subject term: D002289Q000235Q000401Q000601
has primary subject term: D004260Q000235
has primary subject term: D004273Q000235
has primary subject term: D008175Q000235Q000401Q000601
has primary subject term: D020641Q000235
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D005260
has subject term: D006801
has subject term: D053208
has subject term: D008297
has subject term: D008875
has subject term: D015999
has subject term: D011379
has subject term: D012189
has subject term: D015996
source: J Surg Res. 2011-05-01;167(1):e5-12.
volume: 167

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
pmid: 20083228
abstract: Genomic alterations such as chromosomal amplifications, deletions and loss of heterozygosity play an important role in the pathogenesis and progression of cancer. Environmental risk factors contribute to the development and progression of tumors by facilitating the loss of tumor suppressor genes and amplification of oncogenes. In this current study, Affymetrix 10K single nucleotide polymorphism (SNP) arrays were used to evaluate genomic alterations in 20 pairs of matched germ-line and tumor DNA obtained from patients with esophageal squamous cell carcinoma (ESCC) from high-risk area of India where tobacco, betel quid and alcohol use are widespread. Twenty-two amplified regions and 16 deleted regions identified across chromosomal arms were biologically relevant. The candidate genes located at amplified regions of chromosomes or low-level gain regions such as PLA2G5 (1p36-p34), COL11A1 (1p21), KCNK2 (1q41), S100A3 (1q21), ENAH (1q42.12), RGS1 (1q31), KCNH1 (1q32-q41), INSIG2 (2q14.1), FGF12 (3q28), TRIO (5p15.2), RNASEN (5p15.2), FGF10 (5p13-p12), EDN1(6p24.1-p22.3), SULF1 (8q13.2-13.3), TLR4 (9q32-q33), TNC (9q33), NTRK2 (9q22.1), CD44 (11p13), NCAM1 (11q23.1), TRIM29 (11q22-q23), PAK1 (11q13-q14) and RAB27A (15q15-q21.1), are found to be associated with cellular migration and proliferation, tumor cell metastasis and invasion, anchorage independent growth and inhibition of apoptosis. The candidate genes located at deleted regions of chromosomes, such as FBLN2 (3p25.1), WNT7A (3p25), DLC1 (8p22), LZTS1 (8p22), CDKN2A (9p21), COL4A1 (13q34), CDK8 (13q12) and DCC (18q21.3), are found to be associated with the suppression of tumor. The suggested candidate genes were mostly involved in potential signaling pathways such as focal adhesion (COL4A1), tight junction (CLDN10), MAPK signaling pathway (FGF12) and neuroactive ligand receptor interaction pathway (CCKAR). Expression of FGF12 and COL4A1 was validated by tissue microarray. These unique copy number alteration profiles [cell cut: 2169 characters, first 2000 kept]
rights: Copyright © 2010 Elsevier B.V. All rights reserved.
has PII: S1383-5718(10)00025-2
doi: 10.1016/j.mrgentox.2010.01.001
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Chattopadhyay I
      type: Person
      first name: Indranil
      last name: Chattopadhyay
      member of: Institute of Pathology, New Delhi 110029, India.
  slot:
    index: 2
    item: Singh A
      type: Person
      first name: Avninder
      last name: Singh
  slot:
    index: 3
    item: Phukan R
      type: Person
      first name: Rupkumar
      last name: Phukan
  slot:
    index: 4
    item: Purkayastha J
      type: Person
      first name: Joydeep
      last name: Purkayastha
  slot:
    index: 5
    item: Kataki A
      type: Person
      first name: Amal
      last name: Kataki
  slot:
    index: 6
    item: Mahanta J
      type: Person
      first name: Jagadish
      last name: Mahanta
  slot:
    index: 7
    item: Saxena S
      type: Person
      first name: Sunita
      last name: Saxena
  slot:
    index: 8
    item: Kapur S
      type: Person
      first name: Sujala
      last name: Kapur
created: 2010-1-20T06:00
date last updated: 2025-01-17
issued: 2010-02
dp: 2010 Feb
ISSN: 0027-5107
has issn l: 0027-5107
issue: 2
has NLM journal title abbreviation: Mutat Res
publication name: Mutation research
language: eng
has national library of medicine journal id: 0400763
derived from: NLM
starting page: 130
ending page: 8
has place of publication: Netherlands
has primary subject term: D001114Q000009
has primary subject term: D002294Q000235
has primary subject term: D002869
has primary subject term: D004938Q000235
has primary subject term: D009153Q000633
has subject term: D056915Q000187
has subject term: D005784
has subject term: D017353
has subject term: D006801
has subject term: D007194
has subject term: D012306
has subject term: D015398Q000187
source: Mutat Res. 2010-02;696(2):130-8.
volume: 696

The federal government's senseless policy change on tobacco warning labels.
pmid: 21059774
has PII: cmaj.101583
doi: 10.1503/cmaj.101583
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Stanbrook MB
      type: Person
      first name: Matthew B
      last name: Stanbrook
  slot:
    index: 2
    item: Hébert PC
      type: Person
      first name: Paul C
      last name: Hébert
created: 2010-11-10T06:00
date last updated: 2025-01-17
issued: 2010-12-14
dp: 2010 Dec 14
e ISSN: 1488-2329
has issn l: 0820-3946
issue: 18
has NLM journal title abbreviation: CMAJ
publication name: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
language: eng
has national library of medicine journal id: 9711805
derived from: NLM
pg: 1939
has place of publication: Canada
has primary subject term: D035082
has primary subject term: D009538Q000009
has primary subject term: D011050
has primary subject term: D014029Q000517
has subject term: D002170
has subject term: D006801
source: CMAJ. 2010-12-14;182(18):1939.
volume: 182

The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development.
pmid: 21426550
abstract: In this work, we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia. We have also tried to evaluate whether these variants affect the bladder tumor stage and grade.The patients group was constituted of 193 newly diagnosed cases of bladder tumors. The controls group was constituted of non-related healthy subjects. The rs2228001, rs13181 and rs17655 polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism technique.Our data have reported that non smoker and light smoker patients (1-19PY) are protected against bladder cancer development. Moreover, light smokers have less risk for developing advanced tumors stage. When we investigated the effect of genetic polymorphisms in bladder cancer development we have found that ERCC2 and ERCC5 variants were not implicated in the bladder cancer occurrence. However, the mutated homozygous genotype for XPC gene was associated with 2.09-fold increased risk of developing bladder cancer compared to the control carrying the wild genotype (p = 0.03, OR = 2.09, CI 95% 1.09-3.99). Finally, we have found that the XPC, ERCC2 and ERCC5 variants don't affect the tumors stage and grade.These results suggest that the mutated homozygous genotype for XPC gene was associated with increased risk of developing bladder. However we have found no association between rs2228001, rs13181 and rs17655 polymorphisms and tumors stage and grade.
has PII: 1471-2407-11-101
doi: 10.1186/1471-2407-11-101
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Rouissi K
      type: Person
      first name: Kamel
      last name: Rouissi
      member of: Laboratory of Genetic, Immunology and Human Pathology, Faculty of Sciences of Tunis, University of El Manar I. Tunis, Tunisia.
  slot:
    index: 2
    item: Bahria IB
      type: Person
      first name: Islem Ben
      last name: Bahria
  slot:
    index: 3
    item: Bougatef K
      type: Person
      first name: Karim
      last name: Bougatef
  slot:
    index: 4
    item: Marrakchi R
      type: Person
      first name: Raja
      last name: Marrakchi
  slot:
    index: 5
    item: Stambouli N
      type: Person
      first name: Nejla
      last name: Stambouli
  slot:
    index: 6
    item: Hamdi K
      type: Person
      first name: Khouloud
      last name: Hamdi
  slot:
    index: 7
    item: Cherif M
      type: Person
      first name: Mohamed
      last name: Cherif
  slot:
    index: 8
    item: Ben Slama MR
      type: Person
      first name: Mohamed Riadh
      last name: Ben Slama
  slot:
    index: 9
    item: Sfaxi M
      type: Person
      first name: Mohamed
      last name: Sfaxi
  slot:
    index: 10
    item: Othman FB
      type: Person
      first name: Fethi Ben
      last name: Othman
  slot:
    index: 11
    item: Chebil M
      type: Person
      first name: Mohamed
      last name: Chebil
  slot:
    index: 12
    item: Elgaaied AB
      type: Person
      first name: Amel Benammar
      last name: Elgaaied
  slot:
    index: 13
    item: Ouerhani S
      type: Person
      first name: Slah
      last name: Ouerhani
created: 2011-3-24T06:00
date last updated: 2025-01-17
issued: 2011-03-22
dp: 2011 Mar 22
e ISSN: 1471-2407
has issn l: 1471-2407
has NLM journal title abbreviation: BMC Cancer
publication name: BMC cancer
language: eng
has national library of medicine journal id: 100967800
derived from: NLM
pg: 101
has place of publication: England
has primary subject term: D002277Q000235Q000473
has primary subject term: D004268Q000235Q000378Q000502
has primary subject term: D004720Q000235Q000378Q000502
has primary subject term: D009687Q000235Q000378Q000502
has primary subject term: D020641Q000502
has primary subject term: D014157Q000235Q000378Q000502
has primary subject term: D001749Q000235Q000473
has primary subject term: D051759Q000235Q000378Q000502
has subject term: D000368
has subject term: D016022
has subject term: D004198
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D009367
has subject term: D009538Q000494
source: BMC Cancer. 2011-03-22;11():101.
volume: 11

Prostate-specific antigen: its relationship with alcohol intake and tobacco.
pmid: 21484082
abstract: To determine the influence of alcohol and tobacco consumption on serum prostate-specific antigen (PSA) levels. 59 men participated in this study: 20 with prostate tumors (PT) and 39 without tumor diagnosis (prostate controls, PC) (mean 66 and 58 years, respectively). PSA was analyzed in serum samples and its values were compared through the Kruskal-Wallis nonparametric test. Alcohol and tobacco consumption was also considered. PSA mean value was higher than 4 ng/ml in PT, whereas in PC it was lower than that value. Statistically significant differences were found when comparing PSA between PT and PC (P < 0.05). PSA was higher in alcohol and tobacco consumers than in non-consumers in PT group (P < 0.05). For PC, PSA mean values were higher in non-smokers than in smokers. Statistically significant differences were observed for serum PSA when compared between PT and PC groups considering alcohol and tobacco consumption (P < 0.05). Serum PSA values appear to be influenced by alcohol and tobacco consumption.
doi: 10.1007/s12032-011-9940-x
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Escandriolo Nackauzi JD
      type: Person
      first name: Jorge D
      last name: Escandriolo Nackauzi
      member of: Cátedra de Anatomía, Facultad de Odontología, Universidad Nacional de Córdoba, Av. Pueyrredón 2335, Bº Alto Alberdi, 5003 Córdoba, Argentina. escandriolojorge@odo.unc.edu.ar
  slot:
    index: 2
    item: Colla RH
      type: Person
      first name: Raúl H
      last name: Colla
  slot:
    index: 3
    item: Ravazzani GR
      type: Person
      first name: Graciela R
      last name: Ravazzani
  slot:
    index: 4
    item: Gaido MI
      type: Person
      first name: María I
      last name: Gaido
  slot:
    index: 5
    item: Bertolotto P
      type: Person
      first name: Patricia
      last name: Bertolotto
  slot:
    index: 6
    item: Actis AB
      type: Person
      first name: Adriana B
      last name: Actis
created: 2011-4-13T06:00
date last updated: 2025-01-17
issued: 2012-06
dp: 2012 Jun
e ISSN: 1559-131X
has issn l: 1357-0560
issue: 2
has NLM journal title abbreviation: Med Oncol
publication name: Medical oncology (Northwood, London, England)
language: eng
has national library of medicine journal id: 9435512
derived from: NLM
starting page: 823
ending page: 6
has place of publication: United States
has primary subject term: D000230Q000097Q000175Q000209
has primary subject term: D000428Q000009
has primary subject term: D014408Q000097
has primary subject term: D017430Q000097
has primary subject term: D011470Q000097Q000175Q000209
has primary subject term: D011471Q000097Q000175Q000209
has subject term: D016022
has subject term: D006801
has subject term: D008297
source: Med Oncol. 2012-06;29(2):823-6.
volume: 29

El Habano and the world it has shaped: Cuba, Connecticut, and Indonesia.
pmid: 21506307
abstract: In the half century since the 1959 Cuban Revolution, El Habano remains the premium cigar the world over; but both before and since 1959, the seed, agricultural and industrial know-how, and human capital have been transplanted to replicate that cigar in a process accentuated by upheavals and out-migration. The focus here is on a little-known facet of the interconnected island and offshore Havana cigar history, linking Cuba with Connecticut and Indonesia: from when tobacco was taken from the Americas to Indonesia and gave rise to the famed Sumatra cigar wrapper leaf; through the rise and demise of its sister shade wrapper in Connecticut, with Cuban and Sumatra seed, ultimately overshadowed by Indonesia; and the resulting challenges facing Cuba today. The article highlights the role of Dutch, U.S., British, and Swedish capital to explain why in 2009 the two major global cigar corporations, British Imperial Tobacco and Swedish Match, were lobbying Washington, respectively, for and against the embargo on Cuba. As the antismoking, antitobacco lobby gains ground internationally, the intriguing final question is whether the future lies with El Habano or smokeless Swedish snus.
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Stubbs J
      type: Person
      first name: Jean
      last name: Stubbs
created: 2010-1-1T00:00
date last updated: 2025-01-17
issued: 2010
dp: 2010
created: 2011-4-22T06:00
ISSN: 0361-4441
has issn l: 0361-4441
has NLM journal title abbreviation: Cuban Stud
publication name: Cuban studies
language: eng
has national library of medicine journal id: 100967298
derived from: HMD
starting page: 39
ending page: 67
has place of publication: United States
has primary subject term: D003132Q000191Q000193Q000266
has primary subject term: D011634Q000191Q000193Q000266Q000331
has primary subject term: D012907Q000191Q000208Q000266
has primary subject term: D019460Q000191Q000193Q000266
has subject term: D003237Q000208
has subject term: D018556Q000191Q000266
has subject term: D003462Q000208
has subject term: D049673
has subject term: D049674
has subject term: D007214Q000208
has subject term: D018515
has subject term: D011639Q000266
source: Cuban Stud. 2010;41():39-67.
volume: 41

[Assessment health damage from use of tobacco aromatizers].
pmid: 19102013
abstract: Some concentrated natural tobacco aromatizers (FL-Marwal, FL-Achshe, FL-Vlakot) and casings (CC-Catjas, CC-Wenget, CC-Krawat) from British American Tobacco Germany GmbH (Germany) imported into the Republic of Uzbekistan to be used in the manufacture of cigarettes were tested. The author's toxicological studies have revealed that the test agents may be recommended for use in the manufacture of cigarettes as safe tobacco aromatizers and casings. The normal life span reduction caused by the test natural concentrated tobacco aromatizers and casings in the hygienic range will be expected to be 3-6 days a year.
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Elinskaia OL
      type: Person
      first name: O L
      last name: Elinskaia
created: 2008-12-23T09:00
date last updated: 2025-01-17
ISSN: 0016-9900
has issn l: 0016-9900
issue: 4
has NLM journal title abbreviation: Gig Sanit
publication name: Gigiena i sanitariia
language: rus
has national library of medicine journal id: 0412700
derived from: NLM
starting page: 13
ending page: 5
has place of publication: Russia (Federation)
has primary subject term: D012906Q000032
has primary subject term: D012907Q000009
has subject term: D000818
has subject term: D004195
has subject term: D005500
has subject term: D006168
has subject term: D008017
has subject term: D008297
has subject term: D011817
has subject term: D051381
has subject term: D012307
has subject term: D019460
source: Gig Sanit. ;(4):13-5.

Epidemiology of multiple myeloma.
pmid: 21509679
abstract: Multiple myelomas are a less frequent cancer site among both sexes. On a worldwide scale, it is estimated that about 86 000 incident cases occur annually, accounting for about 0.8% of all new cancer cases. About 63 000 subjects are reported to die from the disease each year, accounting for 0.9% of all cancer deaths. Geographically, the frequency is very unevenly distributed in the world with the highest incidence in the industrialised regions of Australia / New Zealand, Europe and North America. Incidence and mortality seem to be stable in Asian countries and to increase slowly over the decades among whites in the western countries. The etiology is poorly understood. This depends partly upon the fact that the risk factors which play a major role for malignant diseases in general, such as tobacco consumption and diet have not been found strongly involved into multiple myeloma etiology. Nevertheless, some consistency seems to be in the findings about a risk elevation with obesity and a slightly decreased risk with high fruit consumption. Despite some contradicting results, indications to a role of ionising radiation persist. Finally, infections with HIV and hepatitis C virus appear related to an elevated multiple myeloma risk. Currently, large efforts are undertaken to unravel the etiology of malignant lymphoma including those of multiple myeloma.
doi: 10.1007/978-3-540-85772-3_2
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Becker N
      type: Person
      first name: Nikolaus
      last name: Becker
      member of: German Cancer Research Center, Im Neuenheimer Feld 581, D-69120, Heidelberg, Germany. n.becker@dkfz.de
created: 2011-4-22T06:00
date last updated: 2025-01-17
issued: 2011
dp: 2011
ISSN: 0080-0015
has issn l: 0080-0015
has NLM journal title abbreviation: Recent Results Cancer Res
publication name: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
language: eng
has national library of medicine journal id: 0044671
derived from: NLM
starting page: 25
ending page: 35
has place of publication: Germany
has primary subject term: D009101Q000453Q000209Q000401
has subject term: D000438Q000009
has subject term: D004032Q000009
has subject term: D005260
has subject term: D006728Q000378
has subject term: D006801
has subject term: D015994
has subject term: D007221
has subject term: D008297
has subject term: D009043
has subject term: D009765Q000453
has subject term: D012307
has subject term: D012737
source: Recent Results Cancer Res. 2011;183():25-35.
volume: 183

http://rdf.ncbi.nlm.nih.gov/pubmed/21524094
pmid: 21524094
abstract: O(2)-[4-(3-Pyridyl)-4-oxobut-1-yl]thymidine (O(2)-POB-dThd) is the most persistent adduct detected in the lung and liver of rats treated with tobacco specific nitrosamines: N'-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). It is an important biomarker to assess the human exposure to these carcinogens. The only synthetic method reported for O(2)-POB-dThd requires repeated HPLC purifications and could only be used to prepare an analytical standard due to very low yield (0.4%). We have developed for the first time a regioselective and efficient method for the total synthesis of O(2)-POB-dThd and its site-specifically adducted oligonucleotides. The main step in the synthesis of O(2)-POB-dThd was achieved by a novel method. The treatment of O(2)-5'-anhydrothymidine with the sodium salt of 4-(1,3-dithian-2-yl)-4-(3-pyridyl)butan-1-ol gave exclusively the O(2)-alkylated adduct, which was deprotected in one step to furnish the desired O(2)-POB-dThd in excellent yield. The product was characterized by NMR ((1)H and (13)C), high-resolution MS, and HPLC analysis. This work provided for the first time a reliable method for large scale total synthesis of O(2)-POB-dThd that allowed for solid state site-specifically adducted oligomer synthesis. The O(2)-POB-dThd was converted to its phosphoramidite and subsequently used for the synthesis of oligodeoxynucleotides by standard methods. The oligomers were characterized by MS and HPLC analysis. These oligomers will facilitate the elucidation of the mutagenic potential of the O(2)-POB-dThd adduct, which will provide further insight into the role of tobacco-specific nitrosamines in inducing cancers in smokers.
doi: 10.1021/tx200127j
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Krishnegowda G
      type: Person
      first name: Gowdahalli
      last name: Krishnegowda
      member of: Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States.
  slot:
    index: 2
    item: Sharma AK
      type: Person
      first name: Arun K
      last name: Sharma
  slot:
    index: 3
    item: Krzeminski J
      type: Person
      first name: Jacek
      last name: Krzeminski
  slot:
    index: 4
    item: Gowda AS
      type: Person
      first name: A S Prakasha
      last name: Gowda
  slot:
    index: 5
    item: Lin JM
      type: Person
      first name: Jyh-Ming
      last name: Lin
  slot:
    index: 6
    item: Desai D
      type: Person
      first name: Dhimant
      last name: Desai
  slot:
    index: 7
    item: Spratt TE
      type: Person
      first name: Thomas E
      last name: Spratt
  slot:
    index: 8
    item: Amin S
      type: Person
      first name: Shantu
      last name: Amin
created: 2011-4-29T06:00
date last updated: 2025-01-17
issued: 2011-06-20
dp: 2011 Jun 20
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 6
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 960
ending page: 7
has place of publication: United States
has primary subject term: D002273Q000737
has primary subject term: D018736Q000138Q000737
has primary subject term: D009602Q000737
has primary subject term: D009838Q000138Q000737
has primary subject term: D011725Q000138Q000737
has primary subject term: D013936Q000031Q000138Q000737
has subject term: D001483
has subject term: D006801
has subject term: D013237
has subject term: D014028Q000032
source: Chem Res Toxicol. 2011-06-20;24(6):960-7.
title: Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.
volume: 24

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
pmid: 21625009
abstract: Lung tumors from smokers as well as lung tumors from mice exposed to tobacco carcinogens such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), often carry mutations in K-ras, which activates downstream-signaling pathways such as PI3K/AKT/mTOR pathway. Mice with genetic deletion of one of three isoforms of AKT were used to investigate the role of AKT in mutant K-ras-induced lung tumorigenesis in mice. Although deletion of Akt1 or Akt2 decreased NNK-induced lung tumor formation by 90%, deletion of Akt2 failed to decrease lung tumorigenesis in two other mouse models driven by mutant K-ras. Genetic mapping showed that Akt2 was tightly linked to the cytochrome P450 Cyp2a locus on chromosome 7. Consequently, targeted deletion of Akt2 created linkage to a strain-specific Cyp2a5 polymorphism that decreased activation of NNK in vitro. Mice with this Cyp2a5 polymorphism had decreased NNK-induced DNA adduct formation in vivo and decreased NNK-induced lung tumorigenesis. These studies support human epidemiological studies linking CYP2A polymorphisms with lung cancer risk in humans and highlight the need to confirm phenotypes of genetically engineered mice in multiple mouse strains.
has PII: bgr097
doi: 10.1093/carcin/bgr097
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Hollander MC
      type: Person
      first name: M Christine
      last name: Hollander
      member of: Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  slot:
    index: 2
    item: Zhou X
      type: Person
      first name: Xin
      last name: Zhou
  slot:
    index: 3
    item: Maier CR
      type: Person
      first name: Colleen R
      last name: Maier
  slot:
    index: 4
    item: Patterson AD
      type: Person
      first name: Andrew D
      last name: Patterson
  slot:
    index: 5
    item: Ding X
      type: Person
      first name: Xinxin
      last name: Ding
  slot:
    index: 6
    item: Dennis PA
      type: Person
      first name: Phillip A
      last name: Dennis
created: 2011-6-1T06:00
date last updated: 2025-01-17
issued: 2011-08
dp: 2011 Aug
e ISSN: 1460-2180
has issn l: 0143-3334
issue: 8
has NLM journal title abbreviation: Carcinogenesis
publication name: Carcinogenesis
language: eng
has national library of medicine journal id: 8008055
derived from: NLM
starting page: 1279
ending page: 84
has place of publication: England
has primary subject term: D001189Q000235
has primary subject term: D008175Q000139Q000235Q000473
has primary subject term: D009602Q000633
has primary subject term: D011110Q000235
has primary subject term: D013250Q000235
has subject term: D000818
has subject term: D002273Q000633
has subject term: D005260
has subject term: D015151
has subject term: D008168Q000187
has subject term: D008297
has subject term: D051379
has subject term: D008805
has subject term: D008810
has subject term: D018345
has subject term: D008862Q000187
has subject term: D016133
has subject term: D051057Q000502
source: Carcinogenesis. 2011-08;32(8):1279-84.
volume: 32

Spirometric profile of narghile smokers.
pmid: 21943546
abstract: Studies of the spirometric profiles of narghile smokers are few, have some methodological limits (i.e. small sample size), and present contradictory conclusions.(i) To determine the percentage of narghile smokers with obstructive ventilatory defect (OVD) and/or restrictive ventilatory defect (RVD) or static hyperinflation (SHI); (ii) to compare the chronological and estimated lung ages.men aged 20 to 60 years, narghile smokers (>1 narghile-year [NY]).cigar or cigarette smokers and comorbidity. Narghile use quantification: NY and kg of cumulative tobacco use (1 NY=9.125 kg of cumulative tobacco use).Large airway obstructive ventilatory defect (OVD): forced expired volume in one second (FEV(1))/forced vital capacity (FVC) less than lower limit of normal (LLN). Small airway OVD: FVC more than LLN and decrease (less than LLN) of one or more peripheral flows. RVD: total lung capacity (TLC) less than LLN. SHI: residual volume (RV) more than upper limit of normal. SPIROMETRIC MEASURES: (Vmax 22 Series/6200 Autobox, SensorMedics, Yorba Linda, California, USA with measurement of functional residual capacity by nitrogen washout). Measurements were made according to international recommendations.One hundred and ten narghile smokers were included (34±10 years; 1.76±0.07m; 84±14kg). Thirty-six percent of the subjects had SHI; 14% had small airway OVD; 14% had RVD, and 6% had large airway OVD. Estimated lung age was higher than chronological lung age (47±18 years vs. 34±10 years, P<0.05).Narghile use accelerates lung ageing. This study provides the health authorities with valid arguments to fight this blight on society, which increasingly involves children and pregnant women.
rights: Copyright © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.
has PII: S0761-8425(11)00284-1
doi: 10.1016/j.rmr.2008.10.001
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Ben Saad H
      type: Person
      first name: H
      last name: Ben Saad
      member of: Service de physiologie et des explorations fonctionnelles, EPS Farhat Hached, Sousse, Tunisia. helmi.bensaad@rns.tn
  slot:
    index: 2
    item: Khemis M
      type: Person
      first name: M
      last name: Khemis
  slot:
    index: 3
    item: Bougmiza I
      type: Person
      first name: I
      last name: Bougmiza
  slot:
    index: 4
    item: Prefaut C
      type: Person
      first name: C
      last name: Prefaut
  slot:
    index: 5
    item: Aouina H
      type: Person
      first name: H
      last name: Aouina
  slot:
    index: 6
    item: Mrizek N
      type: Person
      first name: N
      last name: Mrizek
  slot:
    index: 7
    item: Garrouche A
      type: Person
      first name: A
      last name: Garrouche
  slot:
    index: 8
    item: Zbidi A
      type: Person
      first name: A
      last name: Zbidi
  slot:
    index: 9
    item: Tabka Z
      type: Person
      first name: Z
      last name: Tabka
created: 2011-9-29T06:00
date last updated: 2025-01-17
issued: 2011-09
dp: 2011 Sep
created: 2011-9-28T06:00
e ISSN: 1776-2588
has issn l: 0761-8425
issue: 7
has NLM journal title abbreviation: Rev Mal Respir
publication name: Revue des maladies respiratoires
language: eng
has national library of medicine journal id: 8408032
derived from: NLM
starting page: e39
ending page: 51
has place of publication: France
has primary subject term: D000402Q000209Q000503
has primary subject term: D009330
has primary subject term: D012907Q000009Q000503Q000639
has primary subject term: D013147
has subject term: D000328
has subject term: D000375
has subject term: D015992
has subject term: D003430
has subject term: D004867
has subject term: D006801
has subject term: D008168Q000473Q000503
has subject term: D008176
has subject term: D008297
has subject term: D008875
has subject term: D012129
has subject term: D012906Q000032
has subject term: D011795
has subject term: D014416
has subject term: D055815
source: Rev Mal Respir. 2011-09;28(7):e39-51.
volume: 28

Plain packaging of tobacco products in Australia: a novel regulation faces legal challenge.
pmid: 22253391
has PII: 307/3/261
doi: 10.1001/jama.2011.2009
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Mitchell AD
      type: Person
      first name: Andrew D
      last name: Mitchell
      member of: Melbourne Law School, University of Melbourne, 207 Bouverie St, Parkville, Victoria 3052, Australia.
  slot:
    index: 2
    item: Studdert DM
      type: Person
      first name: David M
      last name: Studdert
created: 2012-1-19T06:00
date last updated: 2025-01-17
issued: 2012-01-18
dp: 2012 Jan 18
e ISSN: 1538-3598
has issn l: 0098-7484
issue: 3
has NLM journal title abbreviation: JAMA
publication name: JAMA
language: eng
has national library of medicine journal id: 7501160
derived from: NLM
starting page: 261
ending page: 2
has place of publication: United States
has primary subject term: D010330Q000331
has primary subject term: D019064Q000331Q000592
has primary subject term: D011640
has subject term: D001315
has subject term: D003132
has subject term: D010067
has subject term: D019460
has subject term: D062789
source: JAMA. 2012-01-18;307(3):261-2.
volume: 307

Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure.
pmid: 22004967
abstract: This study was aimed to explore the therapeutic effect of sodium ferulate (SF) on rats with intrauterine growth retardation (IUGR), and then to clarify the corresponding mechanism. Pregnant rats were divided into normal group, tobacco/alcohol exposure group, and tobacco/alcohol+SF groups. Fetal developmental indices, placental weight, histological alteration, oxidative and antioxidative-function (e.g. MDA, SOD, CAT) and Mdr1 levels were assayed. Results showed exposure to tobacco/alcohol resulted in reduced fetal developmental indices and placental histological alteration, as well as the increased MDA content, decreased SOD and CAT activities and decreased Mdr1a level. After SF treatment, fetal developmental indices, and placental weight, histological alteration, oxidative and antioxidative-function and mdr1a levels were reversed. Our study indicated SF may be effective in reversing IUGR production, and its underlying mechanism may be due to enhanced placental antioxidative function and P-gp expression, which may be related to IUGR formation by tobacco/alcohol exposure.
rights: Copyright © 2011 Elsevier B.V. All rights reserved.
has PII: S1382-6689(11)00137-2
doi: 10.1016/j.etap.2011.08.013
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Li Y
      type: Person
      first name: Yan
      last name: Li
      member of: Department of Pharmacology of Basic Medical College, Wuhan University, Wuhan 430071, China.
  slot:
    index: 2
    item: Yan YE
      type: Person
      first name: You-E
      last name: Yan
  slot:
    index: 3
    item: Wang H
      type: Person
      first name: Hui
      last name: Wang
created: 2011-10-19T06:00
date last updated: 2025-01-17
issued: 2011-11
dp: 2011 Nov
e ISSN: 1872-7077
has issn l: 1382-6689
issue: 3
has NLM journal title abbreviation: Environ Toxicol Pharmacol
publication name: Environmental toxicology and pharmacology
language: eng
has national library of medicine journal id: 9612020
derived from: NLM
starting page: 465
ending page: 71
has place of publication: Netherlands
has primary subject term: D000975Q000378
has primary subject term: D020168Q000378
has primary subject term: D003373Q000494
has primary subject term: D047109Q000187
has primary subject term: D005317Q000188Q000209
has primary subject term: D010920Q000187
has subject term: D000818
has subject term: D005260
has subject term: D008297
has subject term: D011247
has subject term: D051381
has subject term: D018435Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000097202
has subject term: D002374Q000378
has subject term: D000431Q000009
has subject term: D009929Q000187
has subject term: D017207
has subject term: D013482Q000378
has subject term: D015430Q000187
has subject term: D011297
has subject term: D014028
source: Environ Toxicol Pharmacol. 2011-11;32(3):465-71.
volume: 32

Determinants of tobacco use and renaming the FTND to the Fagerstrom Test for Cigarette Dependence.
pmid: 22025545
has PII: ntr137
doi: 10.1093/ntr/ntr137
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Fagerström K
      type: Person
      first name: Karl
      last name: Fagerström
      member of: Fagerström Consulting, Jordkull 3670, 26878 Kagerod, Sweden. karl.fagerstrom@swipnet.se
created: 2011-10-26T06:00
date last updated: 2025-01-17
issued: 2012-01
dp: 2012 Jan
e ISSN: 1469-994X
has issn l: 1462-2203
issue: 1
has NLM journal title abbreviation: Nicotine Tob Res
publication name: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
language: eng
has national library of medicine journal id: 9815751
derived from: NLM
starting page: 75
ending page: 8
has place of publication: England
has primary subject term: D011795
has primary subject term: D014029Q000175Q000209Q000523
has subject term: D004850
has subject term: D006801
has subject term: D009538Q000009
has subject term: D012907Q000009Q000523
source: Nicotine Tob Res. 2012-01;14(1):75-8.
volume: 14

Graphene oxide: an efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes.
pmid: 22039588
abstract: Graphene oxide was found to be a highly efficient, reusable and cost-effective organocatalyst for the aza-Michael addition of amines to activated alkenes to furnish corresponding β-amino compounds in excellent yields.
doi: 10.1039/c1cc15230k
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Verma S
      type: Person
      first name: Sanny
      last name: Verma
      member of: Chemical Sciences Division, Indian Institute of Petroleum, Mohkampur, Dehradun-248005, India.
  slot:
    index: 2
    item: Mungse HP
      type: Person
      first name: Harshal P
      last name: Mungse
  slot:
    index: 3
    item: Kumar N
      type: Person
      first name: Neeraj
      last name: Kumar
  slot:
    index: 4
    item: Choudhary S
      type: Person
      first name: Shivani
      last name: Choudhary
  slot:
    index: 5
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
  slot:
    index: 6
    item: Sain B
      type: Person
      first name: Bir
      last name: Sain
  slot:
    index: 7
    item: Khatri OP
      type: Person
      first name: Om P
      last name: Khatri
created: 2011-11-1T06:00
date last updated: 2025-01-17
issued: 2011-12-21
dp: 2011 Dec 21
e ISSN: 1364-548X
has issn l: 1359-7345
issue: 47
has NLM journal title abbreviation: Chem Commun (Camb)
publication name: Chemical communications (Cambridge, England)
language: eng
has national library of medicine journal id: 9610838
derived from: NLM
starting page: 12673
ending page: 5
has place of publication: England
source: Chem Commun (Camb). 2011-12-21;47(47):12673-5.
volume: 47

Social profile and habits of oral cancer patients in Ibadan.
pmid: 22428520
abstract: The aim of this study was to compare the socioeconomic profile and social habits of oral cancer patients and those of control subjects in order to investigate the relative importance of these risk factors in the occurrence of oral cancer.Thirty-two histologically diagnosed oral carcinoma patients and 30 normal patients were recruited at the dental centre University College Hospital, Ibadan. A 33-item questionnaire was administered to the two groups. The data obtained was analyzed using student t test and chi square as appropriate as well as odds ratio.Incomes less than 50,000 naira per annum, absence of fruit in every diet and tobacco use, were associated with 5.7, 3.0 and 4.05 increased risk of oral cancer respectively.Low income, fruit depleted diet and tobacco use seems to be the most important risk factors for oral cancer development in the studied environment.
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lawal A
      type: Person
      first name: A
      last name: Lawal
      member of: Department of Oral Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria. toytoy219@yahoo.com
  slot:
    index: 2
    item: Kolude B
      type: Person
      first name: B
      last name: Kolude
  slot:
    index: 3
    item: Adeyemi BF
      type: Person
      first name: B F
      last name: Adeyemi
  slot:
    index: 4
    item: Lawoyin J
      type: Person
      first name: J
      last name: Lawoyin
  slot:
    index: 5
    item: Akang E
      type: Person
      first name: E
      last name: Akang
created: 2012-3-21T06:00
date last updated: 2025-01-17
issued: 2011-09
dp: 2011 Sep
ISSN: 0309-3913
has issn l: 0309-3913
issue: 3
has NLM journal title abbreviation: Afr J Med Med Sci
publication name: African journal of medicine and medical sciences
language: eng
has national library of medicine journal id: 7801013
derived from: NLM
starting page: 247
ending page: 51
has place of publication: Nigeria
has primary subject term: D002294Q000453Q000209
has primary subject term: D006184
has primary subject term: D009062Q000453Q000209
has primary subject term: D012959
has subject term: D000328
has subject term: D000368
has subject term: D000428Q000009Q000453
has subject term: D016022
has subject term: D004032
has subject term: D005260
has subject term: D005638
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D009549Q000453
has subject term: D009909
has subject term: D012307
has subject term: D012907Q000009Q000453
has subject term: D011795
has subject term: D014675
source: Afr J Med Med Sci. 2011-09;40(3):247-51.
volume: 40

Searching for an indicator of the influence of the tobacco lobby on politicians.
pmid: 21961476
has PII: S0749-3797(11)00488-0
doi: 10.1016/j.amepre.2011.07.002
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Braillon A
      type: Person
      first name: Alain
      last name: Braillon
  slot:
    index: 2
    item: Dubois G
      type: Person
      first name: Gérard
      last name: Dubois
created: 2011-10-4T06:00
date last updated: 2025-01-17
issued: 2011-10
dp: 2011 Oct
e ISSN: 1873-2607
has issn l: 0749-3797
issue: 4
has NLM journal title abbreviation: Am J Prev Med
publication name: American journal of preventive medicine
language: eng
has national library of medicine journal id: 8704773
derived from: NLM
pg: e29
has place of publication: Netherlands
has primary subject term: D008119
has primary subject term: D011057
has primary subject term: D019460Q000331
has subject term: D000329
source: Am J Prev Med. 2011-10;41(4):e29.
volume: 41

Thiourea dioxide promoted efficient organocatalytic one-pot synthesis of a library of novel heterocyclic compounds.
pmid: 21881671
abstract: The utility of thiourea dioxide as an efficient organocatalyst for the library synthesis of novel heterocyclic compounds via one-pot multicomponent coupling reactions is disclosed. Thiourea dioxide is an inexpensive and readily accessible catalyst, resulting in better product yields as compared to the corresponding thiourea as catalyst. Thiourea dioxide is found to be insoluble in various organic solvents and therefore at the end of the reaction products can be separated by extraction with diethyl ether and the recovered catalyst can be used several times with consistent catalytic activity.
doi: 10.1039/c1ob05818e
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Verma S
      type: Person
      first name: Sanny
      last name: Verma
      member of: Chemical Sciences Division, Indian Institute of Petroleum, Dehradun, India 248005.
  slot:
    index: 2
    item: Kumar S
      type: Person
      first name: Subodh
      last name: Kumar
  slot:
    index: 3
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
  slot:
    index: 4
    item: Sain B
      type: Person
      first name: Bir
      last name: Sain
created: 2011-9-2T06:00
date last updated: 2025-01-17
issued: 2011-10-21
dp: 2011 Oct 21
e ISSN: 1477-0539
has issn l: 1477-0520
issue: 20
has NLM journal title abbreviation: Org Biomol Chem
publication name: Organic & biomolecular chemistry
language: eng
has national library of medicine journal id: 101154995
derived from: NLM
starting page: 6943
ending page: 8
has place of publication: England
source: Org Biomol Chem. 2011-10-21;9(20):6943-8.
volume: 9

Cigarette smoke radioactivity and lung cancer risk.
pmid: 21956761
abstract: To determine the tobacco industry's policy and action with respect to radioactive polonium 210 ((210)Po) in cigarette smoke and to assess the long-term risk of lung cancer caused by alpha particle deposits in the lungs of regular smokers.Analysis of major tobacco industries' internal secret documents on cigarette radioactivity made available online by the Master Settlement Agreement in 1998.The documents show that the industry was well aware of the presence of a radioactive substance in tobacco as early as 1959. Furthermore, the industry was not only cognizant of the potential cancerous growth in the lungs of regular smokers but also did quantitative radiobiological calculations to estimate the long-term (25 years) lung radiation absorption dose (rad) of ionizing alpha particles emitted from the cigarette smoke. Our own calculations of lung rad of alpha particles match closely the rad estimated by the industry. According to the Environmental Protection Agency, the industry's and our estimate of long-term lung rad of alpha particles causes 120-138 lung cancer deaths per year per 1,000 regular smokers. Acid wash was discovered in 1980 to be highly effectively in removing (210)Po from the tobacco leaves; however, the industry avoided its use for concerns that acid media would ionize nicotine converting it into a poorly absorbable form into the brain of smokers thus depriving them of the much sought after instant nicotine kick sensation.The evidence of lung cancer risk caused by cigarette smoke radioactivity is compelling enough to warrant its removal.
has PII: ntr145
doi: 10.1093/ntr/ntr145
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Karagueuzian HS
      type: Person
      first name: Hrayr S
      last name: Karagueuzian
      member of: Translational Arrhythmia Research Section, Cardiovascular Research Laboratories, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 675 Charles E. Young Drive South, MRL 1630, Mail Code: 176022, Los Angeles, CA 90095, USA. hkaragueuzian@mednet.ucla.edu
  slot:
    index: 2
    item: White C
      type: Person
      first name: Celia
      last name: White
  slot:
    index: 3
    item: Sayre J
      type: Person
      first name: James
      last name: Sayre
  slot:
    index: 4
    item: Norman A
      type: Person
      first name: Amos
      last name: Norman
created: 2011-10-1T06:00
date last updated: 2025-01-17
issued: 2012-01
dp: 2012 Jan
created: 2011-9-30T06:00
e ISSN: 1469-994X
has issn l: 1462-2203
issue: 1
has NLM journal title abbreviation: Nicotine Tob Res
publication name: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
language: eng
has national library of medicine journal id: 9815751
derived from: NLM
starting page: 79
ending page: 90
has place of publication: England
has primary subject term: D008175Q000209
has primary subject term: D009381Q000209
has primary subject term: D011059Q000009Q000032
has primary subject term: D012906Q000009Q000032
has primary subject term: D019460Q000266Q000331Q000379
has subject term: D006801
has subject term: D049673
has subject term: D008168Q000737Q000528
has subject term: D011829
has subject term: D012306
has subject term: D012907Q000009Q000266
has subject term: D014481
has subject term: D009538
source: Nicotine Tob Res. 2012-01;14(1):79-90.
volume: 14

Subjective effects for alcohol, tobacco, and marijuana association with cross-drug outcomes.
pmid: 22445481
abstract: The cross-drug relationship of subjective experiences between alcohol, tobacco, and marijuana and problem drug use behaviors were examined. Data were drawn from 3853 individuals between the ages of 11 and 30 years of age participating in the Colorado Center on Antisocial Drug Dependence [CADD]. Subjective experiences were assessed using a 13-item questionnaire that included positive and negative responses for alcohol, tobacco, and marijuana. Lifetime abuse and dependence on these three drugs was assessed using the Composite International Diagnostic Interview, Substance Abuse Module [CIDI-SAM].Positive and negative subjective experience scales were similar for alcohol, tobacco, and marijuana, although the hierarchical ordering of items differed by drug. Subjective experience scales for each of the three drugs examined correlated significantly, with the strongest relationship being for alcohol and marijuana experiences. Significant associations were identified between how a person experienced a drug and abuse and dependence status for the same or different drug.Cross-drug relationships provide evidence for a common liability or sensitivity towards responding in a similar manner to drugs of abuse within and across different pharmacological classes.
rights: Published by Elsevier Ireland Ltd.
has PII: S0376-8716(12)00066-X
doi: 10.1016/j.drugalcdep.2012.02.014
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Zeiger JS
      type: Person
      first name: Joanna S
      last name: Zeiger
      member of: Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309-0447, USA.
  slot:
    index: 2
    item: Haberstick BC
      type: Person
      first name: Brett C
      last name: Haberstick
  slot:
    index: 3
    item: Corley RP
      type: Person
      first name: Robin P
      last name: Corley
  slot:
    index: 4
    item: Ehringer MA
      type: Person
      first name: Marissa A
      last name: Ehringer
  slot:
    index: 5
    item: Crowley TJ
      type: Person
      first name: Thomas J
      last name: Crowley
  slot:
    index: 6
    item: Hewitt JK
      type: Person
      first name: John K
      last name: Hewitt
  slot:
    index: 7
    item: Hopfer CJ
      type: Person
      first name: Christian J
      last name: Hopfer
  slot:
    index: 8
    item: Stallings MC
      type: Person
      first name: Michael C
      last name: Stallings
  slot:
    index: 9
    item: Young SE
      type: Person
      first name: Susan E
      last name: Young
  slot:
    index: 10
    item: Rhee SH
      type: Person
      first name: Soo Hyun
      last name: Rhee
created: 2012-3-27T06:00
date last updated: 2025-01-17
issued: 2012-06
dp: 2012 Jun
e ISSN: 1879-0046
has issn l: 0376-8716
has NLM journal title abbreviation: Drug Alcohol Depend
publication name: Drug and alcohol dependence
language: eng
has national library of medicine journal id: 7513587
derived from: NLM
starting page: S52
ending page: 8
has place of publication: Ireland
has primary subject term: D002188
has primary subject term: D004644Q000187
has primary subject term: D000431
has primary subject term: D019966Q000523
has subject term: D000293
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D012044
has subject term: D018709
has subject term: D011795
has subject term: D055815
source: Drug Alcohol Depend. 2012-06;123 Suppl 1():S52-8.
volume: 123 Suppl 1

Frequency and outcomes of accidental ingestion of tobacco products in young children.
pmid: 21821089
abstract: This review assesses published literature related to frequency and outcomes associated with accidental ingestion of tobacco and pharmaceutical nicotine products among young children. Twenty-seven years of annual reports by American Association of Poison Control Centers (AAPCC) were analyzed for occurrence and outcomes associated with accidental ingestion events involving tobacco and pharmaceutical nicotine products among young children. Over a 27-year period, and of >50 million contacts for all categories combined, 217,340 contacts involving ingestion of tobacco products were reported. Approximately 89% involved children <6 years old. One fatality was reported, however the co-ingestion of both cigarettes and diazepam complicates an assessment of a contributory role of tobacco. The rate of major, non-fatal, outcomes was <0.1%. Data from AAPCC reports and other sources indicate the frequency of accidental poisoning events is relatively low for tobacco products compared with other products such as drugs, dietary supplements, cleaning products, and personal care products. These findings, along with those for pharmaceutical nicotine products, are consistent with published case reports and reviews, indicating that the frequency and severity of outcomes associated with accidental ingestion of tobacco products by young children appear to be relatively low. However, adults should keep tobacco products out of the reach of children.
rights: Copyright © 2011 Elsevier Inc. All rights reserved.
has PII: S0273-2300(11)00155-3
doi: 10.1016/j.yrtph.2011.07.010
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Appleton S
      type: Person
      first name: Scott
      last name: Appleton
      member of: Altria Client Services, 601 East Jackson Street, Richmond, VA 23219, USA. Scott.Appleton@altria.com
created: 2011-8-9T06:00
date last updated: 2025-01-17
issued: 2011-11
dp: 2011 Nov
e ISSN: 1096-0295
has issn l: 0273-2300
issue: 2
has NLM journal title abbreviation: Regul Toxicol Pharmacol
publication name: Regulatory toxicology and pharmacology : RTP
language: eng
has national library of medicine journal id: 8214983
derived from: NLM
starting page: 210
ending page: 4
has place of publication: Netherlands
has primary subject term: D009538Q000506
has subject term: D002648
has subject term: D006801
has subject term: D000059
has subject term: D004435
has subject term: D011039
has subject term: D062789
source: Regul Toxicol Pharmacol. 2011-11;61(2):210-4.
volume: 61

Volatile organics off-gassed among tobacco-exposed clothing fabrics.
pmid: 21852036
abstract: This work evaluates the characteristics of short-term release of volatile and semi-volatile organic chemicals from clothing fabrics that are exposed to environmental tobacco smoke (ETS). Various fabrics were concurrently exposed to ETS in a controlled facility, and the chemicals off-gassed were sampled using solid phase micro-extraction coupled with GC/MS analysis. Toluene-reference concentration (TRC) was calculated for nine selected chemicals and compared. The number of chemicals identified from ETS-exposed fabrics ranged from 13 (polyester and acetate) to 32 (linen). All fabrics off-gassed formaldehyde, tetradecanoic acid and n-hexadecanoic acid, while seven out of eight fabrics emitted furfural, benzonitrile, naphthalene and decanal. Natural fibers of plant origin (cotton and linen) off-gassed higher concentrations (TRC>100 μg/l) of chemicals that have low molecular weight (~100 or less) than did natural fibers of animal origin (wool and silk) and synthetic fibers. Conversely, wool and silk off-gassed more chemicals that are of high molecular weight (>200), such as TDA (TRC>100 μg/l) and n-HDA (TRC>500 μg/l), than did other fabrics. Fabric structure (for a particular material) significantly affects chemical off-gassing. Cotton typically used for polo shirt (knitted) off-gassed significantly (p<0.05) higher TRC for chemicals with molecular weight of ~100 (such as furfural) than did other cottons of woven style. The dyeing of fabric (white vs. black) had a limited effect on emission, while increasing contact time with ETS increased the intensity of chemical emissions. The mean TRC for cotton exposed for 12 min was nearly doubled than those exposed for 8min, but no difference existed for polyester.
rights: Copyright © 2011. Published by Elsevier B.V.
has PII: S0304-3894(11)00923-X
doi: 10.1016/j.jhazmat.2011.07.042
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Chien YC
      type: Person
      first name: Yeh-Chung
      last name: Chien
      member of: Department of Safety, Health and Environmental Engineering, Hungkuang University, Taichung, Taiwan. ycchien@yuntech.edu.tw
  slot:
    index: 2
    item: Chang CP
      type: Person
      first name: Cheng-Ping
      last name: Chang
  slot:
    index: 3
    item: Liu ZZ
      type: Person
      first name: Zheng-Zhe
      last name: Liu
created: 2011-8-20T06:00
date last updated: 2025-01-17
issued: 2011-10-15
dp: 2011 Oct 15
e ISSN: 1873-3336
has issn l: 0304-3894
has NLM journal title abbreviation: J Hazard Mater
publication name: Journal of hazardous materials
language: eng
has national library of medicine journal id: 9422688
derived from: NLM
starting page: 139
ending page: 48
has place of publication: Netherlands
has primary subject term: D003020
has primary subject term: D055549
source: J Hazard Mater. 2011-10-15;193():139-48.
volume: 193

P53, p16 and Ki67 immunoexpression in oral squamous carcinomas.
pmid: 22395505
abstract: In this study, we have analyzed clinically, histopathologically and immunohistochemically a total of 34 cases of oral squamous carcinoma in 11 of the cases being identified adjacent epithelial dysplastic lesions. Carcinomas were diagnosed in patients aged 40-60 years, males, with chronic exposure to tobacco and/or alcohol, being located especially on the lips. Well-differentiated carcinomas have been predominant (52.9%) in stage I/II tumoral (88.3%). Immunoexpression analysis of p53, p16 and Ki67 did not reveal statistically significant differences between the expression of markers and clinical or histopathological parameters, except Ki67 whose increased expression was associated to the decrease of the degree of tumoral differentiation and with high degree dysplasia. The positivity index and the intensity of reaction were increased at the level of dysplasic epithelium for p16 and at the level of tumoral invasion front for the p53 and Ki67. The study highlights the value of the immunostain for p16 in identifying dysplasic lesions and predictive importance of p53 and Ki67 markers in identifying the aggressive forms of oral carcinomas.
has PII: 530112089093
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Dragomir LP
      type: Person
      first name: L P
      last name: Dragomir
      member of: Department of Occlusology Dental Prosthetics, University of Medicine and Pharmacy of Craiova, Romania.
  slot:
    index: 2
    item: Simionescu C
      type: Person
      first name: Cristiana
      last name: Simionescu
  slot:
    index: 3
    item: Mărgăritescu C
      type: Person
      first name: Cl
      last name: Mărgăritescu
  slot:
    index: 4
    item: Stepan A
      type: Person
      first name: A
      last name: Stepan
  slot:
    index: 5
    item: Dragomir IM
      type: Person
      first name: Iuliana Manuela
      last name: Dragomir
  slot:
    index: 6
    item: Popescu MR
      type: Person
      first name: M R
      last name: Popescu
created: 2012-3-8T06:00
date last updated: 2025-01-17
issued: 2012
dp: 2012
e ISSN: 2066-8279
has issn l: 1220-0522
issue: 1
has NLM journal title abbreviation: Rom J Morphol Embryol
publication name: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
language: eng
has national library of medicine journal id: 9112454
derived from: NLM
starting page: 89
ending page: 93
has place of publication: Romania
has primary subject term: D002294Q000378
has primary subject term: D020869
has primary subject term: D015972
has primary subject term: D019394Q000096
has primary subject term: D009062Q000378
has primary subject term: D009363Q000096
has primary subject term: D016159Q000096
has subject term: D000328
has subject term: D002454
has subject term: D019941
has subject term: D004848Q000473
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
source: Rom J Morphol Embryol. 2012;53(1):89-93.
volume: 53

[Tobacco: the taxation is also a tool of public health].
pmid: 22464404
has PII: S0398-7620(12)00058-2
doi: 10.1016/j.respe.2012.03.001
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Bourdillon F
      type: Person
      first name: F
      last name: Bourdillon
  slot:
    index: 2
    item: Lakhdar CB
      type: Person
      first name: C Ben
      last name: Lakhdar
  slot:
    index: 3
    item: Salamon R
      type: Person
      first name: R
      last name: Salamon
created: 2012-4-3T06:00
date last updated: 2025-01-17
issued: 2012-04
dp: 2012 Apr
ISSN: 0398-7620
has issn l: 0398-7620
issue: 2
has NLM journal title abbreviation: Rev Epidemiol Sante Publique
publication name: Revue d'epidemiologie et de sante publique
language: fre
has national library of medicine journal id: 7608039
derived from: NLM
starting page: 79
ending page: 80
has place of publication: France
has primary subject term: D009538
has primary subject term: D011634Q000379
has primary subject term: D013660
has subject term: D006801
source: Rev Epidemiol Sante Publique. 2012-04;60(2):79-80.
volume: 60

Deregulation of Beclin 1 in patients with tobacco-related oral squamous cell carcinoma.
pmid: 22627130
abstract: Autophagy is a physiologically regulated and evolutionary conserved process that plays a critical role in degradation of cytoplasmic proteins and other macromolecules within the lysosomes. Beclin-1, the mammalian orthologue of yeast Atg6, is an important mediator of autophagy that has been studied in many human cancers. However, the expression of Beclin-1 has not yet been investigated in oral cancer. We for the first time investigated the expression of Beclin-1 in serum and tissues and correlated it with the clinic-pathological features of oral cancer patients. m-RNA expression of Beclin-1 was evaluated in tumor and normal areas of surgical specimens from 10 oral cancer patients by real-time PCR. Approximately, 8-fold lower expression (p<0.001) of Beclin-1 mRNA was observed in tumor tissue as compared to the normal tissue. Serum levels of Beclin-1 were evaluated by SPR and ELISA. No significant difference was observed in serum Beclin-1 levels in patients as compared to healthy subjects, similarly no correlation was found between serum levels and clinic-pathological parameters such as stage, lymph node involvement and tumor size. Our results demonstrate that down-regulation of Beclin-1 may play an important role in the development and progression of oral cancer possibly by dysregulation of autophagy in tumor cells.
rights: Copyright © 2012 Elsevier Inc. All rights reserved.
has PII: S0006-291X(12)00956-4
doi: 10.1016/j.bbrc.2012.05.079
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kapoor V
      type: Person
      first name: Vaishali
      last name: Kapoor
      member of: Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. kapoor.vaishali@gmail.com
  slot:
    index: 2
    item: Paliwal D
      type: Person
      first name: Daizy
      last name: Paliwal
  slot:
    index: 3
    item: Baskar Singh S
      type: Person
      first name: S
      last name: Baskar Singh
  slot:
    index: 4
    item: Mohanti BK
      type: Person
      first name: Bidhu Kalyan
      last name: Mohanti
  slot:
    index: 5
    item: Das SN
      type: Person
      first name: Satya Narayan
      last name: Das
created: 2012-5-26T06:00
date last updated: 2025-01-17
issued: 2012-06-15
dp: 2012 Jun 15
e ISSN: 1090-2104
has issn l: 0006-291X
issue: 4
has NLM journal title abbreviation: Biochem Biophys Res Commun
publication name: Biochemical and biophysical research communications
language: eng
has national library of medicine journal id: 0372516
derived from: NLM
starting page: 764
ending page: 9
has place of publication: United States
has primary subject term: D051017Q000096Q000097
has primary subject term: D001343
has primary subject term: D002294Q000097Q000209Q000378
has primary subject term: D008565Q000096Q000097
has primary subject term: D009062Q000097Q000209Q000378
has subject term: D000328
has subject term: D000368
has subject term: http://id.nlm.nih.gov/mesh/D000071186
has subject term: D015536
has subject term: D004797
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D055815
source: Biochem Biophys Res Commun. 2012-06-15;422(4):764-9.
volume: 422

Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer.
pmid: 22660220
abstract: Polymorphisms in the genes that code for metabolic enzymes involved in either the activation (Phase I) or detoxication (Phase II) of chemical carcinogens in tobacco, may alter expression or function of carcinogenic compounds and hence alter risk of oral cancer. The present study investigates whether polymorphisms at CYP1A1 and GSTM1 gene loci act as risk factors for oral precancerous lesions and cancer.For the present study, histopathologically confirmed cases of 90 oral precancerous lesions, 150 oral squamous cell carcinoma (SCC) and 150 control subjects were selected. Polymerase chain reaction and restriction fragment length polymorphism were performed using DNA from blood samples to determine the polymorphic genotypes at CYP1A1 and GSTM1 loci.CYP1A1 C (m2/m2) genotype conferred a 12.0 fold-increased risk (OR=12.0; 95% CI, 2.40-60.05) to oral SCC. GSTM1 null showed no significant association but the frequency was higher in oral SCC cases. Patients with genotype C and/or GSTM1 deficiency developed carcinoma after less tobacco consumption than those of other genotypes though the difference was not statistically significant. The frequency of the combined genotypes C and GSTM1 null was found to be 14% among oral SCC patients. On comparing the susceptibility of intraoral sites it was found that in the majority of cases (64%) in the study groups they were the buccal mucosa.Hence it was concluded that metabolic enzymes reported in the present study: CYP1A1 significantly alter oral cancer risk. GSTM1 null and CYP1A1 C (m2m2) show a predisposition to premalignant lesions and cancer of the buccal mucosa than other sites.
doi: 10.5507/bp.2012.013
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Shukla D
      type: Person
      first name: Deepika
      last name: Shukla
      member of: Department of Oral Pathology and Microbiology, Faculty of Dentistry, Jamia Millia Islamia, Delhi, India.
  slot:
    index: 2
    item: Dinesh Kale A
      type: Person
      first name: Alka
      last name: Dinesh Kale
  slot:
    index: 3
    item: Hallikerimath S
      type: Person
      first name: Seema
      last name: Hallikerimath
  slot:
    index: 4
    item: Vivekanandhan S
      type: Person
      first name: Subbiah
      last name: Vivekanandhan
  slot:
    index: 5
    item: Venkatakanthaiah Y
      type: Person
      first name: Yerrmalla
      last name: Venkatakanthaiah
created: 2012-6-5T06:00
date last updated: 2025-01-17
issued: 2012-09
dp: 2012 Sep
e ISSN: 1804-7521
has issn l: 1213-8118
issue: 3
has NLM journal title abbreviation: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
publication name: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
language: eng
has national library of medicine journal id: 101140142
derived from: NLM
starting page: 253
ending page: 9
has place of publication: Czech Republic
has primary subject term: D002273Q000378
has primary subject term: D002294Q000235
has primary subject term: D019363Q000235
has primary subject term: D020022
has primary subject term: D005982Q000235
has primary subject term: D009062Q000235
has primary subject term: D011110
has primary subject term: D011230Q000235
has subject term: D000328
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D012150
has subject term: D012307
source: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012-09;156(3):253-9.
volume: 156

Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: a preliminary investigation.
pmid: 22820891
abstract: Children prenatally exposed to tobacco exhibit higher rates of learning and emotional-behavioral problems related to worse working memory performance. Brain function, however, among tobacco exposed children while performing a working memory task has not previously been examined. This study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a number N-back working memory task using an event-related functional magnetic resonance imaging (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, and sex were statistically controlled. Tobacco-exposed children showed greater activation in inferior parietal regions, whereas unexposed children showed greater activation in inferior frontal regions. These differences were observed in the context of correct responses, suggesting that exposed and unexposed children use different brain regions and approaches to succeed in working memory tasks. Implications for future research and intervention are discussed.
doi: 10.1007/s11682-012-9192-1
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Bennett DS
      type: Person
      first name: David S
      last name: Bennett
      member of: GLAD Program, Drexel University College of Medicine, Building C, Box 118, 4700 Wissahickon Avenue, Philadelphia, PA 19144, USA. David.Bennett@DrexelMed.edu
  slot:
    index: 2
    item: Mohamed FB
      type: Person
      first name: Feroze B
      last name: Mohamed
  slot:
    index: 3
    item: Carmody DP
      type: Person
      first name: Dennis P
      last name: Carmody
  slot:
    index: 4
    item: Malik M
      type: Person
      first name: Muhammed
      last name: Malik
  slot:
    index: 5
    item: Faro SH
      type: Person
      first name: Scott H
      last name: Faro
  slot:
    index: 6
    item: Lewis M
      type: Person
      first name: Michael
      last name: Lewis
created: 2012-7-24T06:00
date last updated: 2025-01-17
issued: 2013-03
dp: 2013 Mar
e ISSN: 1931-7565
has issn l: 1931-7557
issue: 1
has NLM journal title abbreviation: Brain Imaging Behav
publication name: Brain imaging and behavior
language: eng
has national library of medicine journal id: 101300405
derived from: NLM
starting page: 49
ending page: 59
has place of publication: United States
has primary subject term: D001921Q000033Q000187Q000502
has primary subject term: D008570Q000187
has subject term: D000293
has subject term: D000328
has subject term: D002492Q000009
has subject term: D002648
has subject term: D004781
has subject term: D000431Q000009
has subject term: D005260
has subject term: D006801
has subject term: D007091
has subject term: D008137
has subject term: D008279
has subject term: D008297
has subject term: D017397Q000502
has subject term: D011247
has subject term: D011297
has subject term: D011597Q000502
has subject term: D012306
has subject term: D014028Q000009
source: Brain Imaging Behav. 2013-03;7(1):49-59.
volume: 7

Regular black tea habit could reduce tobacco associated ROS generation and DNA damage in oral mucosa of normal population.
pmid: 22705326
abstract: Tobacco and tea habit are very common in world wide. In the present study, an attempt was made to evaluate the effect of regular drinking of black tea on reactive oxygen species (ROS) generation and DNA damage in buccal cells of normal subjects with or without tobacco habit. Expression of ROS associated proteins IκB, NF-κB as well as DNA repair associated proteins p53, MLH1 were also analyzed. Exfoliated buccal cells were collected from 308 healthy individuals and classified according to age, tobacco and tea habits. In all age groups, comparatively high ROS level and significantly high DNA damage frequency were seen in individuals with tobacco habit than the subjects without tea and tobacco habits. Tea habit effectively lowered ROS level and restrict DNA damage in tobacco users irrespective of ages. The DNA damage seen in the subjects was not associated with apoptosis. Moreover, tea habit effectively lowered the expression of IκB, NF-κB, p53 and MLH1 in tobacco users in all age groups. It seems that regular black tea habit could have anti-genotoxic effect as revealed by reduced tobacco associated ROS generation and DNA damage in buccal cells.
rights: Copyright © 2012 Elsevier Ltd. All rights reserved.
has PII: S0278-6915(12)00419-X
doi: 10.1016/j.fct.2012.06.005
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Pal D
      type: Person
      first name: Debolina
      last name: Pal
      member of: Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India.
  slot:
    index: 2
    item: Sur S
      type: Person
      first name: Subhayan
      last name: Sur
  slot:
    index: 3
    item: Mandal S
      type: Person
      first name: Shyamsundar
      last name: Mandal
  slot:
    index: 4
    item: Das S
      type: Person
      first name: Sukta
      last name: Das
  slot:
    index: 5
    item: Panda CK
      type: Person
      first name: Chinmay Kumar
      last name: Panda
created: 2012-6-19T06:00
date last updated: 2025-01-17
issued: 2012-09
dp: 2012 Sep
e ISSN: 1873-6351
has issn l: 0278-6915
issue: 9
has NLM journal title abbreviation: Food Chem Toxicol
publication name: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
language: eng
has national library of medicine journal id: 8207483
derived from: NLM
starting page: 2996
ending page: 3003
has place of publication: England
has primary subject term: D004249
has primary subject term: D009061Q000378
has primary subject term: D017382Q000378
has primary subject term: D013662
has subject term: D000368
has subject term: D020552
has subject term: D005260
has subject term: D006801
has subject term: D007150
has subject term: D020287
has subject term: D008297
has subject term: D008875
source: Food Chem Toxicol. 2012-09;50(9):2996-3003.
volume: 50

Memory ability and hippocampal volume in adolescents with prenatal drug exposure.
pmid: 22652523
abstract: The objective of the present study was to examine the influence of prenatal drug exposure (PDE) on memory performance and supporting brain structures (i.e., hippocampus) during adolescence. To achieve this goal, declarative memory ability and hippocampal volume were examined in a well-characterized sample of 138 adolescents (76 with a history of PDE and 62 from a non-exposed comparison group recruited from the same community, mean age=14 years). Analyses were adjusted for: age at time of the assessments, gender, IQ, prenatal exposure to alcohol and tobacco, and indices of early childhood environment (i.e., caregiver depression, potential for child abuse, and number of caregiver changes through 7 years of age). Results revealed that adolescents with a history of PDE performed worse on the California Verbal Learning Test-Child Version (CVLT-C), and story recall from the Children's Memory Scale (CMS), and had larger hippocampal volumes, even after covariate adjustment. Hippocampal volume was negatively correlated with memory performance on the CVLT-C, with lower memory scores associated with larger volumes. These findings provide support for long-term effects of PDE on memory function and point to neural mechanisms that may underlie these outcomes.
rights: Copyright © 2012 Elsevier Inc. All rights reserved.
has PII: S0892-0362(12)00119-5
doi: 10.1016/j.ntt.2012.05.054
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Riggins T
      type: Person
      first name: Tracy
      last name: Riggins
      member of: University of Maryland, College Park, USA. riggins@umd.edu
  slot:
    index: 2
    item: Cacic K
      type: Person
      first name: Kelsey
      last name: Cacic
  slot:
    index: 3
    item: Buckingham-Howes S
      type: Person
      first name: Stacy
      last name: Buckingham-Howes
  slot:
    index: 4
    item: Scaletti LA
      type: Person
      first name: Laura A
      last name: Scaletti
  slot:
    index: 5
    item: Salmeron BJ
      type: Person
      first name: Betty Jo
      last name: Salmeron
  slot:
    index: 6
    item: Black MM
      type: Person
      first name: Maureen M
      last name: Black
created: 2012-6-2T06:00
date last updated: 2025-01-17
issued: 2012-07
dp: 2012 Jul
e ISSN: 1872-9738
has issn l: 0892-0362
issue: 4
has NLM journal title abbreviation: Neurotoxicol Teratol
publication name: Neurotoxicology and teratology
language: eng
has national library of medicine journal id: 8709538
derived from: NLM
starting page: 434
ending page: 41
has place of publication: United States
has primary subject term: D000431Q000009
has primary subject term: D006624Q000187Q000254Q000473
has primary subject term: D008569Q000139Q000473Q000503
has primary subject term: D011297Q000139Q000473Q000503
has subject term: D000293
has subject term: D005260
has subject term: D006801
has subject term: D008137
has subject term: D008297
has subject term: D011247
source: Neurotoxicol Teratol. 2012-07;34(4):434-41.
volume: 34

Prevalence of the primary LHON mutations in Northern Finland associated with bilateral optic atrophy and tobacco-alcohol amblyopia.
pmid: 22970697
abstract: Leber hereditary optic neuropathy (LHON) is regarded as the most common mitochondrial disease. We have previously reported comprehensive population-based epidemiological data on common mitochondrial DNA (mtDNA) mutations including m.3243A>G, m.8344A>G and large-scale mtDNA deletions in Northern Finland. Our aim was to investigate the prevalence of primary LHON mutations and mutations in the four mtDNA genes considered hot spots for LHON in the same population.The study population consisted of 42 adult patients with an aetiologically undefined bilateral optic atrophy. The major LHON mutations m.3460G>A, m.11778G>A and m.14484T>C were analysed by restriction fragment length polymorphism (RFLP), and MTND1, MTND6 and MTATP6 genes were sequenced. MTND5 gene was analysed by conformation-sensitive gel electrophoresis (CSGE).No major LHON mutations were found in the population of the province of Northern Ostrobothnia giving the prevalence of these mutations 0-1.36:100 000 (95% CI). However, two main mutations were found elsewhere in Northern Finland, homoplasmic m.11778G>A from Kainuu and heteroplasmic m.3460G>A from Central Ostrobothnia. Furthermore, tobacco-alcohol amblyopia was diagnosed in five patients in the study population and one of them had m.11778G>A.The prevalence of the three major LHON mutations is lower in Northern Finland than elsewhere in Finland or in Western Europe. As LHON and tobacco-alcohol amblyopia have a similar phenotype, we recommend analysing the known LHON-associated mutations before setting tobacco-alcohol amblyopia diagnosis.
rights: © 2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.
doi: 10.1111/j.1755-3768.2012.02506.x
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Korkiamäki P
      type: Person
      first name: Paula
      last name: Korkiamäki
      member of: Department of Ophthalmology, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, FinlandDepartment of Neurology, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, FinlandDepartment of Pediatrics, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, FinlandDepartment of Neurology, Institute of Clinical Medicine, University of Eastern, FinlandDepartment of Neurology, Kuopio University Hospital, Finland.
  slot:
    index: 2
    item: Kervinen M
      type: Person
      first name: Marko
      last name: Kervinen
  slot:
    index: 3
    item: Karjalainen K
      type: Person
      first name: Karoliina
      last name: Karjalainen
  slot:
    index: 4
    item: Majamaa K
      type: Person
      first name: Kari
      last name: Majamaa
  slot:
    index: 5
    item: Uusimaa J
      type: Person
      first name: Johanna
      last name: Uusimaa
  slot:
    index: 6
    item: Remes AM
      type: Person
      first name: Anne M
      last name: Remes
created: 2012-9-14T06:00
date last updated: 2025-01-17
issued: 2013-11
dp: 2013 Nov
e ISSN: 1755-3768
has issn l: 1755-375X
issue: 7
has NLM journal title abbreviation: Acta Ophthalmol
publication name: Acta ophthalmologica
language: eng
has national library of medicine journal id: 101468102
derived from: NLM
starting page: 630
ending page: 4
has place of publication: England
has primary subject term: D000437Q000150
has primary subject term: D000550Q000175Q000209
has primary subject term: D004272Q000235
has primary subject term: D029242Q000453Q000235
has primary subject term: D017354
has subject term: D000328
has subject term: D005260
has subject term: D005387Q000453
has subject term: D006801
has subject term: D008297
has subject term: D025261Q000235
has subject term: D017720
has subject term: D009245Q000235
has subject term: D009896
has subject term: D012150
has subject term: D015995
has subject term: D014792
has subject term: D055815
source: Acta Ophthalmol. 2013-11;91(7):630-4.
volume: 91

Abnormal expression of PI3K isoforms in patients with tobacco-related oral squamous cell carcinoma.
pmid: 23228846
abstract: The phosphatidylinositol 3-kinase (PI3K) signaling regulates several cellular functions such as motility, proliferation, angiogenesis and survival.Since there is no information on expression of PI3K isoforms in oral cancer, we studied the expression of different isoforms of PI3K (p110α, p110γ, PI3K-C2, Vps34p and p85α) in tumor samples and PBMC by RT and q-RTPCR and serum levels of PI3K p110α by SPR and ELISA techniques in 108 patients with tobacco-related oral squamous cell carcinoma (OSCC) and 46 normal subjects.We observed significantly higher PI3K p110α (p<0.0001) and lower (p<0.0001) vesicular sorting protein 34p (Vps34p) mRNA both in PBMC and tissue samples of oral cancer patients as compared to the normal controls. Other PI3K isoforms did not show such change. Circulating PI3K p110α levels were higher in patients (p<0.0001) as compared to healthy subjects, the SPR data showed direct correlation with advancing stage of the disease. PI3K p110α was overexpressed in tumor samples but not in the normal buccal mucosa.Upregulation of circulating PI3K p110α isoform and its direct correlation with increasing tumor load in OSCC patients indicates that it may be a significant prognostic indicator and a suitable target for therapeutic/chemo-preventive strategies for tobacco-related OSCC.
rights: Copyright © 2012 Elsevier B.V. All rights reserved.
has PII: S0009-8981(12)00567-0
doi: 10.1016/j.cca.2012.11.027
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Garg R
      type: Person
      first name: Richa
      last name: Garg
      member of: Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
  slot:
    index: 2
    item: Kapoor V
      type: Person
      first name: Vaishali
      last name: Kapoor
  slot:
    index: 3
    item: Mittal M
      type: Person
      first name: Manasi
      last name: Mittal
  slot:
    index: 4
    item: Singh MK
      type: Person
      first name: Manoj K
      last name: Singh
  slot:
    index: 5
    item: Shukla NK
      type: Person
      first name: Nootan K
      last name: Shukla
  slot:
    index: 6
    item: Das SN
      type: Person
      first name: Satya N
      last name: Das
created: 2012-12-12T06:00
date last updated: 2025-01-17
issued: 2013-02-01
dp: 2013 Feb 01
e ISSN: 1873-3492
has issn l: 0009-8981
has NLM journal title abbreviation: Clin Chim Acta
publication name: Clinica chimica acta; international journal of clinical chemistry
language: eng
has national library of medicine journal id: 1302422
derived from: NLM
starting page: 100
ending page: 6
has place of publication: Netherlands
has primary subject term: D002294Q000235Q000503
has primary subject term: D015972
has primary subject term: D009062Q000235Q000503
has primary subject term: D058539Q000097Q000235Q000378
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D004797
has subject term: D005260
has subject term: D006801
has subject term: D007150
has subject term: D008297
has subject term: D008875
has subject term: D016133
has subject term: D020033
has subject term: D012333Q000378
has subject term: D059467
source: Clin Chim Acta. 2013-02-01;416():100-6.
volume: 416

Current concepts on the effect of environmental factors on cleft lip and palate.
pmid: 23228693
abstract: The aim of this study was to investigate the effect of environmental factors, such as tobacco, alcohol and folic acid intake, obesity, stressful events, low blood levels of zinc and fever during pregnancy, on the incidence of cleft lip and/or palate (CL±P). An electronic search was performed in the Cochrane Reviews, the ISI Web of Knowledge, PubMed and Scopus, along with a manual search to identify other relevant case-control and cohort studies. Quality assessments and an evaluation of publication bias were undertaken. Statistical heterogeneity was examined, and odds ratios (ORs) and 95% confidence intervals (CI) estimated using the random effects model. Of 372 articles initially retrieved, 28 studies were selected as eligible for meta-analysis. No evidence of publication bias was found using funnel plot analysis and the Egger linear regression method. Many studies were classified as low quality due to inadequate case-control data. On the basis of this research, maternal factors most associated with CL±P were: tobacco (OR 1.48), alcohol (OR 1.28), folic acid intake (OR 0.77), obesity (OR 1.26), stressful events (OR 1.41), low blood zinc levels (OR 1.82), and fever during pregnancy (OR 1.30). Folic acid intake by the mother reduced the risk of CL±P in offspring (OR 0.77).
rights: Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
has PII: S0901-5027(12)00421-3
doi: 10.1016/j.ijom.2012.10.008
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Molina-Solana R
      type: Person
      first name: R
      last name: Molina-Solana
      member of: School of Dentistry, University of Seville, Spain.
  slot:
    index: 2
    item: Yáñez-Vico RM
      type: Person
      first name: R M
      last name: Yáñez-Vico
  slot:
    index: 3
    item: Iglesias-Linares A
      type: Person
      first name: A
      last name: Iglesias-Linares
  slot:
    index: 4
    item: Mendoza-Mendoza A
      type: Person
      first name: A
      last name: Mendoza-Mendoza
  slot:
    index: 5
    item: Solano-Reina E
      type: Person
      first name: E
      last name: Solano-Reina
created: 2012-12-12T06:00
date last updated: 2025-01-17
issued: 2013-02
dp: 2013 Feb
e ISSN: 1399-0020
has issn l: 0901-5027
issue: 2
has NLM journal title abbreviation: Int J Oral Maxillofac Surg
publication name: International journal of oral and maxillofacial surgery
language: eng
has national library of medicine journal id: 8605826
derived from: NLM
starting page: 177
ending page: 84
has place of publication: Denmark
has primary subject term: D002971Q000209
has primary subject term: D002972Q000209
has primary subject term: D004781Q000009
has subject term: D000428Q000009
has subject term: D016001
has subject term: D005260
has subject term: D005334Q000150
has subject term: D005492Q000008
has subject term: D006801
has subject term: D007231
has subject term: D008016
has subject term: D016013
has subject term: D016014
has subject term: D009765Q000150
has subject term: D016017
has subject term: D011247
has subject term: D011248
has subject term: D017594
has subject term: D015032Q000097
source: Int J Oral Maxillofac Surg. 2013-02;42(2):177-84.
volume: 42

Tobacco-alcohol amblyopia does not exist.
pmid: 23506382
doi: 10.1111/aos.12101
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Grzybowski A
      type: Person
      first name: Andrzej
      last name: Grzybowski
      member of: Department of Ophthalmology, Poznan City Hospital, Poznan, PolandChair of Ophthalmology, University of Warmia and Mazury, Olsztyn, PolandDepartment of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
  slot:
    index: 2
    item: Pieniążek M
      type: Person
      first name: Martyna
      last name: Pieniążek
created: 2013-3-20T06:00
date last updated: 2025-01-17
issued: 2014-02
dp: 2014 Feb
e ISSN: 1755-3768
has issn l: 1755-375X
issue: 1
has NLM journal title abbreviation: Acta Ophthalmol
publication name: Acta ophthalmologica
language: eng
has national library of medicine journal id: 101468102
derived from: NLM
starting page: e77
ending page: 8
has place of publication: England
has primary subject term: D000437Q000150
has primary subject term: D000550Q000209
has primary subject term: D004272Q000235
has primary subject term: D029242Q000453Q000235
has primary subject term: D017354
has subject term: D005260
has subject term: D006801
has subject term: D008297
source: Acta Ophthalmol. 2014-02;92(1):e77-8.
volume: 92

Impact of tobacco on glutathione S transferase gene loci of Indian ethnics.
pmid: 23244106
abstract: Tobacco contains agents which generate various potent DNA adducts that can cause gene mutations. Production of DNA adducts may be neutralized by glutathione S transferase (GST) along with other phase I and phase II enzyme systems. The existence of null type of GST among the population increases the susceptibility to various disorders and diseases. The present study focuses on the impact of high tobacco usage and possible null type mutation in GST loci.Genotypes of GST were detected by multiplex polymerase chain reaction in unrelated 504 volunteers of high tobacco using natives of Gujarat. Allelic frequencies were calculated using Statistical Package for Social Studies-16 software. Hardy Weinberg Equilibrium (HWE) was calculated using Chi square test. Two sided Fisher's significance test was used to compare allelic frequencies of different populations.The frequency of homozygous null genotype of GSTM1 and GSTT1 were 20% (95% CI 16.7-23.9) and 35.5% (95% CI 31.4-39.9) respectively. The GSTM1 and GSTT1 null allele frequency distribution in the Gujarat population was significantly deviating from HWE. GSTT1 null frequency of Gujaratians was significantly higher and different to all reported low tobacco using Indian ethnics, while GSTM1 was not differing significantly.Tobacco usage significantly influences the rate of mutation and frequency of GSTT1 and M1 null types among the habituates. The rate of mutation in GSTT1 loci was an undeviating response to the dose of tobacco usage among the population. This mutational impact of tobacco on GSTT1 postulates the possible gene - environment interaction and selection of null genotype among the subjects to prone them under susceptible status for various cancers and even worst to cure the population with GSTT1 dependent drugs.
doi: 10.7314/apjcp.2012.13.10.5037
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Senthilkumar KP
      type: Person
      first name: K P
      last name: Senthilkumar
      member of: Department of Zoology, The Madura College (Autonomous), Madurai, India.
  slot:
    index: 2
    item: Thirumurugan R
      type: Person
      first name: Ramasamy
      last name: Thirumurugan
created: 2012-12-19T06:00
date last updated: 2025-01-17
issued: 2012
dp: 2012
e ISSN: 2476-762X
has issn l: 1513-7368
issue: 10
has NLM journal title abbreviation: Asian Pac J Cancer Prev
publication name: Asian Pacific journal of cancer prevention : APJCP
language: eng
has national library of medicine journal id: 101130625
derived from: NLM
starting page: 5037
ending page: 42
has place of publication: Thailand
has primary subject term: D004194Q000209
has primary subject term: D056426Q000235
has primary subject term: D020022
has primary subject term: D005982Q000235
has primary subject term: D011110Q000235
has subject term: D000328
has subject term: D005260
has subject term: D005500
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D011379
has subject term: D012307
source: Asian Pac J Cancer Prev. 2012;13(10):5037-42.
volume: 13

Oral health-related knowledge, attitude, and practices among 12-year-old schoolchildren studying in rural areas of Panchkula, India.
pmid: 22945729
abstract: Oral health is fundamental to general health and well being. Schools can provide a supportive environment for promoting oral health. School policies and education on health-related matters are imperative for the attainment of good oral health and control of related risk behaviors.This study was conducted to assess oral health-related knowledge, attitude, and practices among 12-year-old schoolchildren studying in rural areas of Panchkula, India. The ultimate goal was to implement an oral health-promotion program in this area.A total of 440 children (216 males and 224 females) from 12 schools were included in this study. All the participants were requested to complete a 13-question closed-ended questionnaire. The statistical significance of any difference between the two genders was determined using the Chi-square test.Only 25% of the participants said that they cleaned their teeth more than once in a day. Thirty-two percent did not clean their teeth daily. Over the preceding 1 year, 45.5% of the childern had had some problem with their teeth and/or gums, but only 35.9% visited the dentist. Among these children, 8.2% used tobacco in some form. Oral health-related knowledge of girls was significantly better than that of boys.Based upon the findings of the present study, the knowledge, attitude, and practices of the surveyed children with regard to oral health is poor. Hence, there is a need for regular oral health education of the children, as well as their parents and school teachers.
has PII: IndianJDentRes_2012_23_2_293_100446
doi: 10.4103/0970-9290.100446
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Mehta A
      type: Person
      first name: Abhishek
      last name: Mehta
      member of: Department of Public Health Dentistry, Dr. HS Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh (UT), India.
  slot:
    index: 2
    item: Kaur G
      type: Person
      first name: Gurkiran
      last name: Kaur
created: 2012-9-5T06:00
date last updated: 2025-01-17
e ISSN: 1998-3603
has issn l: 0970-9290
issue: 2
has NLM journal title abbreviation: Indian J Dent Res
publication name: Indian journal of dental research : official publication of Indian Society for Dental Research
language: eng
has national library of medicine journal id: 9202990
derived from: NLM
pg: 293
has place of publication: India
has primary subject term: D007722
has primary subject term: D009909
has primary subject term: D012424
has subject term: D001294
has subject term: D002327Q000627
has subject term: D002648
has subject term: D003729Q000523
has subject term: D003731Q000517
has subject term: D004040Q000009
has subject term: D005260
has subject term: D005459Q000627
has subject term: D015438
has subject term: D006801
has subject term: D007194
has subject term: D008297
has subject term: D010510Q000523
has subject term: D012649
has subject term: D012737
has subject term: D011795
has subject term: D014076Q000523
has subject term: D014099Q000523
has subject term: D014100Q000627
source: Indian J Dent Res. ;23(2):293.
volume: 23

Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors.
pmid: 24222111
abstract: Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor.A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed.The chemoprevention diet had a protective effect against tumor development in the mouse lungs.
has PII: 33/11/4767
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pommergaard HC
      type: Person
      first name: Hans-Christian
      last name: Pommergaard
      member of: Herlev Hospital - University of Copenhagen, Department of Surgery, Herlev Ringvej 75 - DK-2730 Herlev, Denmark. hcpommergaard@gmail.com.
  slot:
    index: 2
    item: Burcharth J
      type: Person
      first name: Jakob
      last name: Burcharth
  slot:
    index: 3
    item: Rosenberg J
      type: Person
      first name: J
      last name: Rosenberg
  slot:
    index: 4
    item: Raskov H
      type: Person
      first name: Hans
      last name: Raskov
created: 2013-11-14T06:00
date last updated: 2025-01-17
issued: 2013-11
dp: 2013 Nov
e ISSN: 1791-7530
has issn l: 0250-7005
issue: 11
has NLM journal title abbreviation: Anticancer Res
publication name: Anticancer research
language: eng
has national library of medicine journal id: 8102988
derived from: NLM
starting page: 4767
ending page: 70
has place of publication: Greece
has primary subject term: D001241Q000008
has primary subject term: D002136Q000008
has primary subject term: D002273Q000633
has primary subject term: D004032
has primary subject term: D008175Q000139Q000473Q000517
has primary subject term: D014807Q000008
has subject term: D000818
has subject term: D000894Q000008
has subject term: D050071Q000008
has subject term: D004195
has subject term: D051379
has subject term: D008805
source: Anticancer Res. 2013-11;33(11):4767-70.
volume: 33

Metallic profile of whole blood and plasma in a series of 106 healthy volunteers.
pmid: 23794607
abstract: In 2003, we simultaneously quantified 27 metals by inductively coupled plasma-mass spectrometry (ICP-MS) in the whole blood, plasma and urine of 100 healthy volunteers. We again determined the metallic profile in whole blood and plasma during 2012. ICP-MS validated multielementary method was performed for metals in whole blood and plasma. Whole blood vanadium and chromium were quantified using ICP-MS collision cell technology. The aims of the study were to compare and assess any changes in this profile, particularly due to the environment. Healthy male/female staff volunteers (n = 106) with no professional exposure to metals, or medication containing lithium, strontium; or food supplements with trace elements and vitamins and with no metal prosthesis were included. Tobacco consumption and the number of dental amalgams were recorded. Our results demonstrated a blood lead level that had drastically decreased, i.e. reduced by half, during this period (12.5 versus 26.3 µg/L, P < 0.0001). Known differences were observed between males and females for copper and zinc; cadmium and lead were higher in smokers. Median plasmatic mercury, a specific test for dental amalgam exposure, did not significantly increase (0.38 versus 0.28 µg/L, P = 0.11). The ICP-MS metallic profile is a very practical concept that is useful for clinical, forensic and environmental toxicology, including industrial hygiene monitoring.
has PII: bkt046
doi: 10.1093/jat/bkt046
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Cesbron A
      type: Person
      first name: Alexandre
      last name: Cesbron
      member of: Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, Le Havre, France.
  slot:
    index: 2
    item: Saussereau E
      type: Person
      first name: Elodie
      last name: Saussereau
  slot:
    index: 3
    item: Mahieu L
      type: Person
      first name: Loïc
      last name: Mahieu
  slot:
    index: 4
    item: Couland I
      type: Person
      first name: Isabelle
      last name: Couland
  slot:
    index: 5
    item: Guerbet M
      type: Person
      first name: Michel
      last name: Guerbet
  slot:
    index: 6
    item: Goullé JP
      type: Person
      first name: Jean-Pierre
      last name: Goullé
created: 2013-6-25T06:00
date last updated: 2025-01-17
issued: 2013-09
dp: 2013 Sep
e ISSN: 1945-2403
has issn l: 0146-4760
issue: 7
has NLM journal title abbreviation: J Anal Toxicol
publication name: Journal of analytical toxicology
language: eng
has national library of medicine journal id: 7705085
derived from: NLM
starting page: 401
ending page: 5
has place of publication: England
has primary subject term: D001774Q000379
has primary subject term: D003723Q000737
has primary subject term: D008670Q000097
has primary subject term: D010949Q000737
has subject term: D000328
has subject term: D000375Q000378
has subject term: D005260
has subject term: D006801
has subject term: D007202
has subject term: D057230
has subject term: D008137
has subject term: D008297
has subject term: D013058
has subject term: D008628Q000097
has subject term: D008631Q000097
has subject term: D008875
has subject term: D011786
has subject term: D012727
has subject term: D013056
has subject term: D055815
source: J Anal Toxicol. 2013-09;37(7):401-5.
volume: 37

Detection of tobacco-related biomarkers in urine samples by surface-enhanced Raman spectroscopy coupled with thin-layer chromatography.
pmid: 23807309
abstract: The nicotine metabolites, cotinine and trans-3'-hydroxycotinine (3HC) are considered as superior biomarkers for identifying tobacco exposure. More importantly, the ratio of 3HC to cotinine is a good indicator to phenotype individuals for cytochrome P450 2A6 activity and to individualize pharmacotherapy for tobacco addiction. In this paper, a simple, robust and novel method based on surface-enhanced Raman spectroscopy coupled with thin-layer chromatography (TLC) was developed to directly quantify the biomarkers in human urine samples. This is the first time surface-enhanced Raman spectroscopy (SERS) was used to detect cotinine and 3HC in urine samples. The linear dynamic range for the detection of cotinine is from 40 nM to 8 μM while that of 3HC is from 1 μM to 15 μM. The detection limits are 10 nM and 0.2 μM for cotinine and 3HC, respectively. The proposed method was further validated by quantifying the concentration of both cotinine and 3HC in smokers' urine samples. This TLC-SERS method allows the direct detection of cotinine in the urine samples of both active and passive smokers and the detection of 3HC in smokers.
doi: 10.1007/s00216-013-7107-7
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Huang R
      type: Person
      first name: Rongfu
      last name: Huang
      member of: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave CHE205, Tampa, FL 33620, USA.
  slot:
    index: 2
    item: Han S
      type: Person
      first name: Sungyub
      last name: Han
  slot:
    index: 3
    item: Li XS
      type: Person
      first name: Xiao Sheryl
      last name: Li
created: 2013-6-29T06:00
date last updated: 2025-01-17
issued: 2013-08
dp: 2013 Aug
e ISSN: 1618-2650
has issn l: 1618-2642
issue: 21
has NLM journal title abbreviation: Anal Bioanal Chem
publication name: Analytical and bioanalytical chemistry
language: eng
has national library of medicine journal id: 101134327
derived from: NLM
starting page: 6815
ending page: 22
has place of publication: Germany
has primary subject term: D002855Q000379
has primary subject term: D003367Q000652
has primary subject term: D009538Q000652
has primary subject term: D012907Q000652
has primary subject term: D013059Q000379
has subject term: D015415Q000652
has subject term: D006801
source: Anal Bioanal Chem. 2013-08;405(21):6815-22.
volume: 405

Oral chemoprevention with acetyl salicylic Acid, vitamin D and calcium reduces the risk of tobacco carcinogen-induced bladder tumors in mice.
pmid: 23915073
abstract: Bladder cancer is a common urological malignancy with high recurrence rate, which may be reduced by chemoprevention. The aim was to evaluate chemoprevention in a mouse model of tobacco carcinogen-induced bladder tumors. A total of 60 A/J mice were randomized to normal diet, diet with low calcium, and diet with chemoprevention (acetyl salicylic acid, 1-alpha 25(OH)2-vitamin D3 and calcium). There were significantly fewer tumors (0 (0-0) vs. 0 (0-2), p = .045) and fewer animals with tumors (0/20 vs. 5/20, p = .045) in the chemoprevention group compared with controls. Thus, chemoprevention diet effectively reduced the tumor promoting effect of tobacco carcinogens in the mouse bladder.
doi: 10.3109/07357907.2013.820316
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pommergaard HC
      type: Person
      first name: H C
      last name: Pommergaard
      member of: Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark. hcpommergaard@gmail.com
  slot:
    index: 2
    item: Burcharth J
      type: Person
      first name: J
      last name: Burcharth
  slot:
    index: 3
    item: Rosenberg J
      type: Person
      first name: J
      last name: Rosenberg
  slot:
    index: 4
    item: Raskov H
      type: Person
      first name: H
      last name: Raskov
created: 2013-8-7T06:00
date last updated: 2025-01-17
issued: 2013-08
dp: 2013 Aug
e ISSN: 1532-4192
has issn l: 0735-7907
issue: 7
has NLM journal title abbreviation: Cancer Invest
publication name: Cancer investigation
language: eng
has national library of medicine journal id: 8307154
derived from: NLM
starting page: 490
ending page: 3
has place of publication: England
has primary subject term: D001241Q000008
has primary subject term: D002118Q000008
has primary subject term: D002136Q000008
has primary subject term: D001749Q000139Q000517
has primary subject term: D014807Q000008
has subject term: D000284
has subject term: D000818
has subject term: D002273Q000633
has subject term: D004195
has subject term: D051379
has subject term: D012907Q000009
source: Cancer Invest. 2013-08;31(7):490-3.
volume: 31

Nanocrystalline starch grafted palladium(II) complex for the Mizoroki-Heck reaction.
pmid: 23969940
abstract: Nanocrystalline starch produced from the acid hydrolysis of gelatinized starch has been used for the first time to support palladium(II) ethylenediamine complex. The nanocrystalline starch supported Pd(II) complex was found to be an efficient and efficiently recycled catalyst for the Mizoroki-Heck reaction of furans and thiophenes with styrenes under mild reaction conditions.
doi: 10.1039/c3dt51685g
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Verma S
      type: Person
      first name: Sanny
      last name: Verma
      member of: Chemical Sciences Division, CSIR-Indian Institute of Petroleum, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 2
    item: Le Bras J
      type: Person
      first name: Jean
      last name: Le Bras
  slot:
    index: 3
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
  slot:
    index: 4
    item: Muzart J
      type: Person
      first name: Jacques
      last name: Muzart
created: 2013-8-24T06:00
date last updated: 2025-01-17
issued: 2013-10-28
dp: 2013 Oct 28
e ISSN: 1477-9234
has issn l: 1477-9226
issue: 40
has NLM journal title abbreviation: Dalton Trans
publication name: Dalton transactions (Cambridge, England : 2003)
language: eng
has national library of medicine journal id: 101176026
derived from: NLM
starting page: 14454
ending page: 9
has place of publication: England
has primary subject term: D005663Q000737
has primary subject term: D053758Q000737
has primary subject term: D009942Q000138Q000737
has primary subject term: D010165Q000737
has primary subject term: D013213Q000737
has primary subject term: D013876Q000737
has subject term: D002384
has subject term: D005029Q000737
has subject term: D015394
has subject term: D013343Q000737
source: Dalton Trans. 2013-10-28;42(40):14454-9.
volume: 42

Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
pmid: 24469050
abstract: The maintenance cytosine DNA methyltransferase DNMT1 and de novo methyltransferase DNMT3b cooperate to establish aberrant DNA methylation and chromatin complexes to repress gene transcription during cancer development. The expression of DNMT3b was constitutively increased 5-20-fold in hTERT/CDK4-immortalized human bronchial epithelial cells (HBECs) before treatment with low doses of tobacco carcinogens. Overexpression of DNMT3b increased and accelerated carcinogen-induced transformation. Genome-wide profiling of transformed HBECs identified 143 DNMT3b-target genes, many of which were transcriptionally regulated by the polycomb repressive complex 2 (PRC2) complex and silenced through aberrant methylation in non-small-cell lung cancer cell lines. Two genes studied in detail, MAL and OLIG2, were silenced during transformation, initially through enrichment for H3K27me3 and H3K9me2, commonly methylated in lung cancer, and exert tumor suppressor effects in vivo through modulating cancer-related pathways. Re-expression of MAL and OLIG2 to physiological levels dramatically reduced the growth of lung tumor xenografts. Our results identify a key role for DNMT3b in the earliest stages of initiation and provide a comprehensive catalog of genes targeted for silencing by this methyltransferase in non-small-cell lung cancer.
has PII: onc2013580
doi: 10.1038/onc.2013.580
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Teneng I
      type: Person
      first name: I
      last name: Teneng
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 2
    item: Tellez CS
      type: Person
      first name: C S
      last name: Tellez
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 3
    item: Picchi MA
      type: Person
      first name: M A
      last name: Picchi
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 4
    item: Klinge DM
      type: Person
      first name: D M
      last name: Klinge
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 5
    item: Yingling CM
      type: Person
      first name: C M
      last name: Yingling
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 6
    item: Snider AM
      type: Person
      first name: A M
      last name: Snider
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 7
    item: Liu Y
      type: Person
      first name: Y
      last name: Liu
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
  slot:
    index: 8
    item: Belinsky SA
      type: Person
      first name: S A
      last name: Belinsky
      member of: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
created: 2014-1-29T06:00
date last updated: 2025-01-17
issued: 2015-01-29
dp: 2015 Jan 29
e ISSN: 1476-5594
has issn l: 0950-9232
issue: 5
has NLM journal title abbreviation: Oncogene
publication name: Oncogene
language: eng
has national library of medicine journal id: 8711562
derived from: NLM
starting page: 621
ending page: 30
has place of publication: England
has primary subject term: D004248Q000235Q000378
has primary subject term: D044127Q000235
has primary subject term: D008175Q000235Q000473
has subject term: D000818
has subject term: D051792Q000096
has subject term: D002273Q000633
has subject term: D002843Q000235
has subject term: http://id.nlm.nih.gov/mesh/D000076123
has subject term: D019175Q000235
has subject term: D015972
has subject term: D006801
has subject term: D008562Q000096
has subject term: D051379
has subject term: D009419Q000096
has subject term: http://id.nlm.nih.gov/mesh/D000076104
has subject term: D063151Q000235Q000378
has subject term: D021381
has subject term: D017472Q000096
has subject term: D019098Q000378
has subject term: D023041
has subject term: http://id.nlm.nih.gov/mesh/D000097584
source: Oncogene. 2015-01-29;34(5):621-30.
volume: 34

Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users.
pmid: 23756756
abstract: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), one of the most prevalent and procarcinogenic compounds in tobacco, is bioactivated by respiratory cytochrome P450 (CYP) 2A13, forming DNA adducts and initiating lung cancer. CYP2A13 inhibition offers a novel strategy for chemoprevention of tobacco-associated lung cancer.Twenty-four analogs of a 4-benzylmorpholine scaffold identified by high throughput screening were evaluated for binding and inhibition of both functional human CYP2A enzymes, CYP2A13 and the 94%-identical hepatic CYP2A6, whose inhibition is undesirable. Thus, selectivity is a major challenge in compound design.A key feature resulting in CYP2A13-selective binding and inhibition was substitution at the benzyl ortho position, with three analogs being >25-fold selective for CYP2A13 over CYP2A6.Two such analogs were negative for genetic and hERG toxicities and metabolically stable in human lung microsomes, but displayed rapid metabolism in human liver and in mouse and rat lung and liver microsomes, likely due to CYP2B-mediated degradation. A specialized knockout mouse mimicking the human lung demonstrates compound persistence in lung and provides an appropriate test model. Compound delivered by inhalation may be effective in the lung but rapidly cleared otherwise, limiting systemic exposure.
doi: 10.1007/s11095-013-1054-z
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Blake LC
      type: Person
      first name: Linda C
      last name: Blake
      member of: Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, Kansas 66045, USA.
  slot:
    index: 2
    item: Roy A
      type: Person
      first name: Anuradha
      last name: Roy
  slot:
    index: 3
    item: Neul D
      type: Person
      first name: David
      last name: Neul
  slot:
    index: 4
    item: Schoenen FJ
      type: Person
      first name: Frank J
      last name: Schoenen
  slot:
    index: 5
    item: Aubé J
      type: Person
      first name: Jeffrey
      last name: Aubé
  slot:
    index: 6
    item: Scott EE
      type: Person
      first name: Emily E
      last name: Scott
created: 2013-6-13T06:00
date last updated: 2025-01-17
issued: 2013-09
dp: 2013 Sep
e ISSN: 1573-904X
has issn l: 0724-8741
issue: 9
has NLM journal title abbreviation: Pharm Res
publication name: Pharmaceutical research
language: eng
has national library of medicine journal id: 8406521
derived from: NLM
starting page: 2290
ending page: 302
has place of publication: United States
has primary subject term: D016588Q000737Q000494
has primary subject term: D001189Q000037Q000378
has primary subject term: D008168Q000187Q000201
has primary subject term: D008175Q000209Q000378Q000517
has primary subject term: D009025Q000737Q000494
has primary subject term: D012907Q000009Q000378
has subject term: D000818
has subject term: D002273Q000378
has subject term: D018890
has subject term: D065637
has subject term: D006801
has subject term: D008099Q000187Q000201
has subject term: D008297
has subject term: D051379
has subject term: D008861Q000187Q000201Q000378
has subject term: D009602Q000009Q000378
has subject term: D051381
source: Pharm Res. 2013-09;30(9):2290-302.
volume: 30

In vitro exposure of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced phospholipase A2 activity.
pmid: 24835565
abstract: Tobacco-specific nitrosamines (TSNA) have implications in the pathogenesis of various lung diseases and conditions are prevalent even in non-smokers. N-nitrosonornicotine (NNN) and 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are potent pulmonary carcinogens present in tobacco product and are mainly responsible for lung cancer. TSNA reacts with pulmonary surfactants, and alters the surfactant phospholipid. The present study was undertaken to investigate the in vitro exposure of rat lung tissue slices to NNK or NNN and to monitor the phospholipid alteration by [(32)P]orthophosphate labeling. Phospholipid content decreased significantly in the presence of either NNK or NNN with concentration and time dependent manner. Phosphatidylcholine (PC) is the main phospholipid of lung and significant reduction was observed in PC ∼61%, followed by phosphatidylglycerol (PG) with 100μM of NNK, whereas NNN treated tissues showed a reduction in phosphatidylserine (PS) ∼60% and PC at 250μM concentration. The phospholipase A2 assays and expression studies reveal that both compounds enhanced phospholipid hydrolysis, thereby reducing the phospholipid content. Collectively, our data demonstrated that both NNK and NNN significantly influenced the surfactant phospholipid level by enhanced phospholipase A2 activity.
rights: Copyright © 2014 Elsevier Ltd. All rights reserved.
has PII: S0887-2333(14)00081-2
doi: 10.1016/j.tiv.2014.05.001
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Vijayaraj P
      type: Person
      first name: Panneerselvam
      last name: Vijayaraj
      member of: Biomembrane Lab, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
  slot:
    index: 2
    item: Sivaprakasam C
      type: Person
      first name: Chinnarasu
      last name: Sivaprakasam
      member of: Biomembrane Lab, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
  slot:
    index: 3
    item: Varthini LV
      type: Person
      first name: Lakshmanaperumal Vishnu
      last name: Varthini
      member of: Biomembrane Lab, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India.
  slot:
    index: 4
    item: Sarkar M
      type: Person
      first name: Mary
      last name: Sarkar
      member of: Biochemistry Department, Indian Institute of Science, Bangalore 560012, India.
  slot:
    index: 5
    item: Nachiappan V
      type: Person
      first name: Vasanthi
      last name: Nachiappan
      member of: Biomembrane Lab, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India. Electronic address: vasanthibch@gmail.com.
created: 2014-5-20T06:00
date last updated: 2025-01-17
issued: 2014-09
dp: 2014 Sep
e ISSN: 1879-3177
has issn l: 0887-2333
issue: 6
has NLM journal title abbreviation: Toxicol In Vitro
publication name: Toxicology in vitro : an international journal published in association with BIBRA
language: eng
has national library of medicine journal id: 8712158
derived from: NLM
starting page: 1097
ending page: 105
has place of publication: England
has primary subject term: D008168Q000187Q000378
has primary subject term: D009602Q000633
has primary subject term: D054467Q000378
has primary subject term: D010743Q000378
has subject term: D000818
has subject term: D008297
has subject term: D017208
source: Toxicol In Vitro. 2014-09;28(6):1097-105.
volume: 28

Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells.
pmid: 25215298
abstract: Genome integrity is essential for normal cellular functions and cell survival. Its instability can cause genetic aberrations and is considered as a hallmark of most cancers. To investigate the carcinogenesis process induced by tobacco-specific carcinogen NNK, we studied the dynamic changes of two important protectors of genome integrity, p53 and MMR system, in malignant transformation of human bronchial epithelial cells after NNK exposure. Our results showed that the expression of MLH1, one of the important MMR proteins, was decreased early and maintained the downregulation during the transformation in a histone modification involved and DNA methylation-independent manner. Another MMR protein PMS2 also displayed a declined expression while being in a later stage of transformation. Moreover, we conducted p53 mutation analysis and revealed a mutation at codon 273 which led to the replacement of arginine by histidine. With the mutation, DNA damage-induced activation of p53 was significantly impaired. We further reintroduced the wild-type p53 into the transformed cells, and the malignant proliferation can be abrogated by inducing cell cycle arrest and apoptosis. These findings indicate that p53 and MMR system play an important role in the initiation and progression of NNK-induced transformation, and p53 could be a potential therapeutic target for tobacco-related cancers.
doi: 10.1155/2014/920275
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Shen Y
      type: Person
      first name: Ying
      last name: Shen
      member of: Department of Clinical Medicine, Zhejiang Medical College, Hangzhou 310053, China.
  slot:
    index: 2
    item: Zhang S
      type: Person
      first name: Shuilian
      last name: Zhang
      member of: Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  slot:
    index: 3
    item: Huang X
      type: Person
      first name: Xiaobin
      last name: Huang
      member of: Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  slot:
    index: 4
    item: Chen K
      type: Person
      first name: Kailin
      last name: Chen
      member of: Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  slot:
    index: 5
    item: Shen J
      type: Person
      first name: Jing
      last name: Shen
      member of: Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  slot:
    index: 6
    item: Wang Z
      type: Person
      first name: Zhengyang
      last name: Wang
      member of: Department of Pulmonology, Sir Run Run Shaw Hospital, Hangzhou 310016, China.
created: 2014-9-13T06:00
date last updated: 2025-01-17
issued: 2014
dp: 2014
e ISSN: 2314-6141
has NLM journal title abbreviation: Biomed Res Int
publication name: BioMed research international
language: eng
has national library of medicine journal id: 101600173
derived from: NLM
pg: 920275
has place of publication: United States
has primary subject term: D048868Q000096
has primary subject term: D000251Q000096
has primary subject term: D002471Q000187Q000235
has primary subject term: D045643Q000096
has primary subject term: D004268Q000096
has primary subject term: D009369Q000139Q000235Q000473
has primary subject term: D009687Q000096
has primary subject term: D016159Q000235
has subject term: D017209Q000187Q000235
has subject term: D001980Q000187Q000473
has subject term: D049109Q000187Q000235
has subject term: D053843Q000187Q000235
has subject term: D004847Q000187Q000473
has subject term: D015972Q000187
has subject term: D042822Q000187Q000235
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000070976
has subject term: http://id.nlm.nih.gov/mesh/D000070957
has subject term: D009602Q000633
source: Biomed Res Int. 2014;2014():920275.
volume: 2014

Photo-induced reduction of CO2 using a magnetically separable Ru-CoPc@TiO2@SiO2@Fe3O4 catalyst under visible light irradiation.
pmid: 25653014
abstract: An efficient photo-induced reduction of CO2 using magnetically separable Ru-CoPc@TiO2@SiO2@Fe3O4 as a heterogeneous catalyst in which CoPc and Ru(bpy)2phene complexes were attached to a solid support via covalent attachment under visible light is described. The as-synthesized catalyst was characterized by a series of techniques including FTIR, UV-Vis, XRD, SEM, TEM, etc. and subsequently tested for the photocatalytic reduction of carbon dioxide using triethylamine as a sacrificial donor and water as a reaction medium. The developed photocatalyst exhibited a significantly higher catalytic activity to give a methanol yield of 2570.78 μmol per g cat after 48 h.
doi: 10.1039/c4dt02461c
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kumar P
      type: Person
      first name: Pawan
      last name: Kumar
      member of: Chemical Sciences Division, CSIR-Indian Institute of Petroleum, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 2
    item: Chauhan RK
      type: Person
      first name: R K
      last name: Chauhan
  slot:
    index: 3
    item: Sain B
      type: Person
      first name: Bir
      last name: Sain
  slot:
    index: 4
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
created: 2015-2-6T06:00
date last updated: 2025-01-17
issued: 2015-03-14
dp: 2015 Mar 14
e ISSN: 1477-9234
has issn l: 1477-9226
issue: 10
has NLM journal title abbreviation: Dalton Trans
publication name: Dalton transactions (Cambridge, England : 2003)
language: eng
has national library of medicine journal id: 101176026
derived from: NLM
starting page: 4546
ending page: 53
has place of publication: England
source: Dalton Trans. 2015-03-14;44(10):4546-53.
volume: 44

Tobacco and alcohol sales in community pharmacies: policy statements from U.S. professional pharmacy associations.
pmid: 24770374
abstract: To characterize the extent to which state and national professional pharmacy associations have implemented formal policies addressing the sale of tobacco and alcohol products in community pharmacies.To determine existence of tobacco and alcohol policies, national professional pharmacy associations (n = 10) and state-level pharmacy associations (n = 86) affiliated with the American Pharmacists Association (APhA) and/or the American Society of Health-System Pharmacists (ASHP) were contacted via telephone and/or e-mail, and a search of the association websites was conducted.Of 95 responding associations (99%), 14% have a formal policy opposing the sale of tobacco products in pharmacies and 5% have a formal policy opposing the sale of alcohol in pharmacies. Of the associations representing major tobacco-producing states, 40% have a formal policy against tobacco sales in pharmacies, significantly more than the 8% of non-tobacco state associations with such policies.Among national professional pharmacy associations, only APhA and ASHP have formal policy statements opposing the sale of both tobacco and alcohol in pharmacies. Most state-level professional pharmacy associations affiliated with these two national organizations have no formal policy statement or position.
has PII: S1544-3191(15)30187-4
doi: 10.1331/JAPhA.2014.13191
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Corelli RL
      type: Person
      first name: Robin L
      last name: Corelli
  slot:
    index: 2
    item: Chai T
      type: Person
      first name: Tiffany
      last name: Chai
  slot:
    index: 3
    item: Karic A
      type: Person
      first name: Alda
      last name: Karic
  slot:
    index: 4
    item: Fairman M
      type: Person
      first name: Melinda
      last name: Fairman
  slot:
    index: 5
    item: Baez K
      type: Person
      first name: Karina
      last name: Baez
  slot:
    index: 6
    item: Hudmon KS
      type: Person
      first name: Karen Suchanek
      last name: Hudmon
created: 2014-4-29T06:00
date last updated: 2025-01-17
e ISSN: 1544-3450
has issn l: 1086-5802
issue: 3
has NLM journal title abbreviation: J Am Pharm Assoc (2003)
publication name: Journal of the American Pharmacists Association : JAPhA
language: eng
has national library of medicine journal id: 101176252
derived from: NLM
starting page: 285
ending page: 8
has place of publication: United States
has primary subject term: D000438Q000009
has primary subject term: D003157Q000331
has primary subject term: D007722
has primary subject term: D010594Q000331
has subject term: D006801
has subject term: D001244
has subject term: D006291
has subject term: D014481
has subject term: D062789
source: J Am Pharm Assoc (2003). ;54(3):285-8.
volume: 54

A prototype tobacco-associated oral squamous cell carcinoma classifier using RNA from brush cytology.
pmid: 23590359
abstract: Oral cancer in the form of squamous cell carcinoma (OSCC) is typically detected in advanced stages when treatment is complex and may not be curative. The need for surgical biopsy may contribute to delays in diagnosis and impede early detection. Multiple studies of RNA from surgically obtained tumor samples have revealed many genes differentially expressed with this disease. We sought to determine whether the identified mRNAs could be used as markers by a non-invasive detection system for OSCC using RNA from brush cytology.Levels of mRNAs from 21 genes known to be differentially expressed in head and neck squamous cell carcinoma surgical samples, compared with controls, were shown to be quantifiable in oral brush cytology samples. These mRNAs were quantified in a training set of 14 tumor and 20 non-malignant brush cytology samples from tobacco/betel nut users. With the measurement of two additional mRNAs and analysis using support vector machines algorithm for class prediction of these cancers was produced.This OSCC classifier based on the levels of 5 mRNAs in RNA from brush cytology initially showed 0.93 sensitivity and 0.91 specificity in differentiating OSCC from benign oral mucosal lesions based on leave-one-out cross-validation. When used on a test set of 19 samples from 6 OSCCs and 13 non-malignant oral lesions, we found misclassification of only one OSCC and one benign lesion.This shows the promise of using RNA from brush cytology for early OSCC detection and the potential for clinical usage of this non-invasive classifier.
rights: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
doi: 10.1111/jop.12068
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Kolokythas A
      type: Person
      first name: Antonia
      last name: Kolokythas
      member of: Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
  slot:
    index: 2
    item: Bosman MJ
      type: Person
      first name: Mitchell J
      last name: Bosman
  slot:
    index: 3
    item: Pytynia KB
      type: Person
      first name: Kristen B
      last name: Pytynia
  slot:
    index: 4
    item: Panda S
      type: Person
      first name: Suchismita
      last name: Panda
  slot:
    index: 5
    item: Sroussi HY
      type: Person
      first name: Herve Y
      last name: Sroussi
  slot:
    index: 6
    item: Dai Y
      type: Person
      first name: Yang
      last name: Dai
  slot:
    index: 7
    item: Schwartz JL
      type: Person
      first name: Joel L
      last name: Schwartz
  slot:
    index: 8
    item: Adami GR
      type: Person
      first name: Guy R
      last name: Adami
created: 2013-4-18T06:00
date last updated: 2025-01-17
issued: 2013-10
dp: 2013 Oct
e ISSN: 1600-0714
has issn l: 0904-2512
issue: 9
has NLM journal title abbreviation: J Oral Pathol Med
publication name: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
language: eng
has national library of medicine journal id: 8911934
derived from: NLM
starting page: 663
ending page: 9
has place of publication: Denmark
has primary subject term: D002294Q000175Q000235
has primary subject term: D003581Q000295
has primary subject term: D055088
has primary subject term: D009062Q000175Q000235
has primary subject term: D012334Q000032
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D001114Q000009
has subject term: D014408Q000032
has subject term: D001706Q000379
has subject term: D005260
has subject term: D020869
has subject term: D015972
has subject term: D006801
has subject term: D007972Q000175Q000473
has subject term: D017676Q000175Q000473
has subject term: D008297
has subject term: D008875
has subject term: D011237
has subject term: D012333Q000032
has subject term: D012372
has subject term: D012680
has subject term: D055815
source: J Oral Pathol Med. 2013-10;42(9):663-9.
volume: 42

Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco.
pmid: 25743199
abstract: Small and detrimental, albeit inconsistent, effects of prenatal cocaine exposure (PCE) during early childhood have been reported. The teratogenic effects of prenatal alcohol (PAE) and tobacco exposure (PTE) on neurobehavior are more firmly established than PCE. We tested if co-exposure to all three drugs could be related to greater differences in brain structure than exposure to cocaine alone. Participants (n=42, PCE=27; age range=14-16 years) received an executive function battery prior to a T1-weighted 3T structural MRI scan. Cortical thickness was measured using FreeSurfer (v5.1). Fetal drug exposure was quantified through maternal self-reports usage during pregnancy. Using general linear modeling, we found no main effects of PCE on cortical thickness, but significant main effects of PAE and PTE in superior and medial frontal regions, after co-varying for the effects of age, sex, and each drug of exposure. Significant alcohol-by-tobacco interactions, and significant cocaine-by-alcohol interactions on cortical thickness in medial parietal and temporal regions were also observed. Poly-drug exposure and cognitive function also showed significant interactions with cortical thickness: lower cortical thickness was associated with better performance in PCE-exposed adolescents. Results suggest that although children with PCE have subtle but persistent brain cortical differences until mid-to-late adolescence.
rights: Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
has PII: S1878-9293(15)00024-9
doi: 10.1016/j.dcn.2015.01.010
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Gautam P
      type: Person
      first name: Prapti
      last name: Gautam
      member of: Department of Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital of Los Angeles, Los Angeles, CA, United States.
  slot:
    index: 2
    item: Warner TD
      type: Person
      first name: Tamara D
      last name: Warner
      member of: Department of Pediatrics, University of Florida, Gainesville, FL, United States.
  slot:
    index: 3
    item: Kan EC
      type: Person
      first name: Eric C
      last name: Kan
      member of: Department of Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital of Los Angeles, Los Angeles, CA, United States.
  slot:
    index: 4
    item: Sowell ER
      type: Person
      first name: Elizabeth R
      last name: Sowell
      member of: Department of Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital of Los Angeles, Los Angeles, CA, United States; Department of Neurology, University of California at Los Angeles, Los Angeles, CA, United States. Electronic address: esowell@chla.usc.edu.
created: 2015-3-7T06:00
date last updated: 2025-01-17
issued: 2015-12
dp: 2015 Dec
e ISSN: 1878-9307
has issn l: 1878-9293
has NLM journal title abbreviation: Dev Cogn Neurosci
publication name: Developmental cognitive neuroscience
language: eng
has national library of medicine journal id: 101541838
derived from: NLM
starting page: 155
ending page: 165
has place of publication: Netherlands
has primary subject term: D002540Q000187Q000473
has primary subject term: D003042Q000009
has primary subject term: D000431Q000009
has primary subject term: D056344Q000187
has primary subject term: D011297Q000473Q000523
has subject term: D000293
has subject term: D000328
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D011247
has subject term: D000367
has subject term: D004305
has subject term: D016014
has subject term: D008279
has subject term: D009483
has subject term: D012737
has subject term: D012923
has subject term: D014028Q000009
source: Dev Cogn Neurosci. 2015-12;16():155-165.
volume: 16

Environmental chemical exposures and autism spectrum disorders: a review of the epidemiological evidence.
pmid: 25199954
abstract: In the past decade, the number of epidemiological publications addressing environmental chemical exposures and autism has grown tremendously. These studies are important because it is now understood that environmental factors play a larger role in causing autism than previously thought and because they address modifiable risk factors that may open up avenues for the primary prevention of the disability associated with autism. In this review, we covered studies of autism and estimates of exposure to tobacco, air pollutants, volatile organic compounds and solvents, metals (from air, occupation, diet, dental amalgams, and thimerosal-containing vaccines), pesticides, and organic endocrine-disrupting compounds such as flame retardants, non-stick chemicals, phthalates, and bisphenol A. We included studies that had individual-level data on autism, exposure measures pertaining to pregnancy or the 1st year of life, valid comparison groups, control for confounders, and adequate sample sizes. Despite the inherent error in the measurement of many of these environmental exposures, which is likely to attenuate observed associations, some environmental exposures showed associations with autism, especially traffic-related air pollutants, some metals, and several pesticides, with suggestive trends for some volatile organic compounds (e.g., methylene chloride, trichloroethylene, and styrene) and phthalates. Whether any of these play a causal role requires further study. Given the limited scope of these publications, other environmental chemicals cannot be ruled out, but have not yet been adequately studied. Future research that addresses these and additional environmental chemicals, including their most common routes of exposures, with accurate exposure measurement pertaining to several developmental windows, is essential to guide efforts for the prevention of the neurodevelopmental damage that manifests in autism symptoms.
rights: Copyright © 2014 Mosby, Inc. All rights reserved.
has PII: S1538-5442(14)00074-1
doi: 10.1016/j.cppeds.2014.06.001
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kalkbrenner AE
      type: Person
      first name: Amy E
      last name: Kalkbrenner
      member of: Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI.
  slot:
    index: 2
    item: Schmidt RJ
      type: Person
      first name: Rebecca J
      last name: Schmidt
      member of: Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA.
  slot:
    index: 3
    item: Penlesky AC
      type: Person
      first name: Annie C
      last name: Penlesky
      member of: Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI.
created: 2014-9-10T06:00
date last updated: 2025-01-17
issued: 2014-11
dp: 2014 Nov
e ISSN: 1538-3199
has issn l: 1538-3199
issue: 10
has NLM journal title abbreviation: Curr Probl Pediatr Adolesc Health Care
publication name: Current problems in pediatric and adolescent health care
language: eng
has national library of medicine journal id: 101134613
derived from: NLM
starting page: 277
ending page: 318
has place of publication: United States
has primary subject term: D002659Q000453Q000209Q000235
has primary subject term: D004785Q000009
has primary subject term: D018811Q000009
has subject term: D005260
has subject term: D006801
has subject term: D019216Q000009
has subject term: D010575Q000009
has subject term: D011247
has subject term: D011297
has subject term: D012307
has subject term: D014611Q000009
source: Curr Probl Pediatr Adolesc Health Care. 2014-11;44(10):277-318.
volume: 44

Which substance is most dangerous? Perceived harm ratings among students in urban and rural Norway.
pmid: 25816858
abstract: Recent studies have challenged the idea that illegal substances are necessarily associated with more harm than those that are legal. This study investigates perceived drug harm among students at the University of Oslo (UO) and at a smaller university located on Norway's coast in a more conservative and religious region, called 'Coastal University' (CU).This study consisted of surveys (n=458) about perceived physical harm, mental health conditions, dependence, injuries and social consequences that may be associated with the use of tobacco, alcohol and cannabis. Information about substance use was also collected. Analyses of variance and multiple regression analyses were used to examine whether harm ratings differed for different drugs, whether drug type, gender and university site interacted in predicting harm ratings, and what role the participants' own substance use played in their harm ratings.UO students rated cannabis as overall less harmful than alcohol, while the opposite was true for CU students. Tobacco received the highest physical harm score. Alcohol was rated as most harmful with regard to injuries; cannabis was rated as most harmful with regard to mental health consequences. Use of the substance in question was associated with a reduced harm rating. This was particularly true for cannabis.Norwegian students rate the harm of substances differently from previous reports from the Norwegian general population. Most importantly, their relative ratings of cannabis harm were lower. However, the pattern was most evident among students from the urban Oslo area.
rights: © 2015 the Nordic Societies of Public Health.
has PII: 1403494815576267
doi: 10.1177/1403494815576267
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Pedersen W
      type: Person
      first name: Willy
      last name: Pedersen
      member of: Department of Sociology and Human Geography, University of Oslo, Norway willy.pedersen@sosgeo.uio.no.
  slot:
    index: 2
    item: Von Soest T
      type: Person
      first name: Tilmann
      last name: Von Soest
      member of: Department of Psychology, University of Oslo and Norwegian Social Research (NOVA), Norway.
created: 2015-3-31T06:00
date last updated: 2025-01-17
issued: 2015-06
dp: 2015 Jun
e ISSN: 1651-1905
has issn l: 1403-4948
issue: 4
has NLM journal title abbreviation: Scand J Public Health
publication name: Scandinavian journal of public health
language: eng
has national library of medicine journal id: 100883503
derived from: NLM
starting page: 385
ending page: 92
has place of publication: Sweden
has primary subject term: D001294
has primary subject term: D002188Q000009
has primary subject term: D000431Q000009
has primary subject term: D012424Q000706
has primary subject term: D013334Q000523Q000706
has primary subject term: D014505Q000706
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D009664Q000453
has subject term: D018570
has subject term: D019966Q000453
has subject term: D014495Q000706
source: Scand J Public Health. 2015-06;43(4):385-92.
volume: 43

Immunoexpression of tenascin as a predictor of the malignancy potential of oral leukoplakia associated with a tobacco habit.
pmid: 25839195
abstract: Oral leukoplakia is a morphological alteration of tissue that is an early indicator for malignancy. Tenascin (TN) is a large hexameric extracellular matrix (ECM) protein with anti-adhesive properties that fosters cell migration during development, wound healing and tissue remodeling; it is present in small amounts in adult tissues. Overexpression of TN in a pathological condition may be either a cause or a consequence of the disease. We evaluated the efficacy of TN for early prediction of tobacco-associated oral cancers. We studied retrospectively 95 cases of oral leukoplakia, including mild, moderate and severe cases, using immunohistochemistry for TN. We evaluated the intensity, area and pattern of TN expression. Greater intensity and area of TN expression was observed in mild and severe dysplasia than in moderate dysplasia. Most cases showed a reticular pattern of expression, especially in mild and moderate dysplasia; a fibrillar pattern was more evident in severe dysplasia. We also observed homogeneous expression pattern in some cases. TN is a marker for dysplastic changes in epithelium and its expression may be helpful for predicting the malignancy potential of tobacco-associated oral leukoplakia.
doi: 10.3109/10520295.2015.1015055
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mane DR
      type: Person
      first name: D R
      last name: Mane
      member of: a Department of Oral Pathology and Microbiology , KLE VK Institute of Dental Sciences and Hospital , Belgaum, Karnataka , India.
  slot:
    index: 2
    item: Bhat K
      type: Person
      first name: K
      last name: Bhat
      member of: b Basic Science Research Laboratory, KLE VK Institute of Dental Sciences and Hospital , Belgaum, Karnataka , India.
  slot:
    index: 3
    item: Kale AD
      type: Person
      first name: A D
      last name: Kale
      member of: a Department of Oral Pathology and Microbiology , KLE VK Institute of Dental Sciences and Hospital , Belgaum, Karnataka , India.
  slot:
    index: 4
    item: Hallikerimath S
      type: Person
      first name: S
      last name: Hallikerimath
      member of: a Department of Oral Pathology and Microbiology , KLE VK Institute of Dental Sciences and Hospital , Belgaum, Karnataka , India.
created: 2015-4-4T06:00
date last updated: 2025-01-17
issued: 2015
dp: 2015
e ISSN: 1473-7760
has issn l: 1052-0295
issue: 7
has NLM journal title abbreviation: Biotech Histochem
publication name: Biotechnic & histochemistry : official publication of the Biological Stain Commission
language: eng
has national library of medicine journal id: 9107378
derived from: NLM
starting page: 544
ending page: 51
has place of publication: England
has primary subject term: D004848Q000378Q000473
has primary subject term: D007972Q000378Q000473
has primary subject term: D009061Q000473
has primary subject term: D009062Q000175Q000473
has subject term: D000328
has subject term: D000368
has subject term: D002465Q000502
has subject term: D016326Q000378
has subject term: D006801
has subject term: D007150Q000379
has subject term: D008875
has subject term: D014945Q000502
has subject term: D055815
source: Biotech Histochem. 2015;90(7):544-51.
volume: 90

Monoamine Oxidase Inhibitors Extracted from Tobacco Smoke as Neuroprotective Factors for Potential Treatment of Parkinson's Disease.
pmid: 25808895
abstract: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of mainly the nigrostriatal dopaminergic neurons, which leads to motor dysfunction. Although, most of the drugs are currently used for symptomatic treatment, there are at least three FDA-approved drugs for the treatment of PD that have been suggested preclinically to have neuroprotective effects. Among these drugs are monoamine oxidase (MAO) type B inhibitors such as selegiline and rasagiline, and non-ergot derivative dopamine agonist, pramipexole. In this review article, we focused on the potential uses of non-selective reversible MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone, from flue-cured tobacco leaves extract and two β- carboline alkaloids (harman and norharman) as potent, reversible and non-selective MAO inhibitors for the treatment of PD. In addition, we discussed the potential uses of farnesol as a potent inhibitor of MAO-B and farnesylacetone as a less potent selective MAO-B inhibitor. Furthermore, adducts of 1,2,3,4-tetrahydroisoquinoline have shown to have competitive inhibitory effects for both MAO-A and MAO-B. These inhibitors have potential neuroprotective effects, which might be mediated at least through nerve growth factor, neurotrophin 3, brain derived neurotrophic factor, and glial-cell-line-derived neurotrophic factor. We suggest here the neuroprotective implication of extracted MAO inhibitors from smoke tobacco; however, it is important to note that there are several existing compounds in tobacco smoke that have toxic effects in the brain, these include and not limited to the induction of neuropathological features observed in individuals suffering from Alzheimer's disease and dementia.
has PII: CNSNDDT-EPUB-66171
doi: 10.2174/1871527314666150325235608
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Sari Y
      type: Person
      first name: Youssef
      last name: Sari
      member of: University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH 43614. USA. youssef.sari@utoledo.edu.
  slot:
    index: 2
    item: Khalil A
      type: Person
      first name: Ashraf
      last name: Khalil
      member of: Qatar University, College of Pharmacy, Pharmaceutical Sciences Section, Doha, Qatar. akhalil@qu.edu.qa.
created: 2015-3-27T06:00
date last updated: 2025-01-17
issued: 2015
dp: 2015
e ISSN: 1996-3181
has issn l: 1871-5273
issue: 6
has NLM journal title abbreviation: CNS Neurol Disord Drug Targets
publication name: CNS & neurological disorders drug targets
language: eng
has national library of medicine journal id: 101269155
derived from: NLM
starting page: 777
ending page: 85
has place of publication: United Arab Emirates
has primary subject term: D008996Q000737Q000627
has primary subject term: D010300Q000188
has primary subject term: D010936Q000737Q000627
has subject term: D000818
has subject term: D006801
has subject term: D012907
source: CNS Neurol Disord Drug Targets. 2015;14(6):777-85.
volume: 14

European rating of drug harms.
pmid: 25922421
abstract: The present paper describes the results of a rating study performed by a group of European Union (EU) drug experts using the multi-criteria decision analysis model for evaluating drug harms.Forty drug experts from throughout the EU scored 20 drugs on 16 harm criteria. The expert group also assessed criteria weights that would apply, on average, across the EU. Weighted averages of the scores provided a single, overall weighted harm score (range: 0-100) for each drug.Alcohol, heroin and crack emerged as the most harmful drugs (overall weighted harm score 72, 55 and 50, respectively). The remaining drugs had an overall weighted harm score of 38 or less, making them much less harmful than alcohol. The overall weighted harm scores of the EU experts correlated well with those previously given by the UK panel.The outcome of this study shows that the previous national rankings based on the relative harms of different drugs are endorsed throughout the EU. The results indicates that EU and national drug policy measures should focus on drugs with the highest overall harm, including alcohol and tobacco, whereas drugs such as cannabis and ecstasy should be given lower priority including a lower legal classification.
rights: © The Author(s) 2015.
has PII: 0269881115581980
doi: 10.1177/0269881115581980
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: van Amsterdam J
      type: Person
      first name: Jan
      last name: van Amsterdam
      member of: Department of Psychiatry, University of Amsterdam, Amsterdam, the Netherlands jan.van.amsterdam@amc.uva.nl.
  slot:
    index: 2
    item: Nutt D
      type: Person
      first name: David
      last name: Nutt
      member of: Centre for Neuropychopharmacology, Imperial College London, London, UK.
  slot:
    index: 3
    item: Phillips L
      type: Person
      first name: Lawrence
      last name: Phillips
      member of: Department of Management, London School of Economics and Political Science, London, UK.
  slot:
    index: 4
    item: van den Brink W
      type: Person
      first name: Wim
      last name: van den Brink
      member of: Department of Psychiatry, University of Amsterdam, Amsterdam, the Netherlands Amsterdam Institute for Addiction Research, Academic Medical Centre, Amsterdam, the Netherlands.
created: 2015-4-30T06:00
date last updated: 2025-01-17
issued: 2015-06
dp: 2015 Jun
e ISSN: 1461-7285
has issn l: 0269-8811
issue: 6
has NLM journal title abbreviation: J Psychopharmacol
publication name: Journal of psychopharmacology (Oxford, England)
language: eng
has national library of medicine journal id: 8907828
derived from: NLM
starting page: 655
ending page: 60
has place of publication: United States
has primary subject term: D013287Q000009Q000331
has subject term: D002188Q000009
has subject term: D000431Q000009
has subject term: D005062
has subject term: D006801
has subject term: D018570
source: J Psychopharmacol. 2015-06;29(6):655-60.
volume: 29

Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.
pmid: 26398225
abstract: The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is a potent lung carcinogen in laboratory animals and is believed to play a key role in the development of lung cancer in smokers. Metabolic activation of NNK leads to the formation of pyridyloxobutyl DNA adducts, a critical step in its mechanism of carcinogenesis. In addition to DNA nucleobase adducts, DNA phosphate adducts can be formed by pyridyloxobutylation of the oxygen atoms of the internucleotidic phosphodiester linkages. We report the use of a liquid chromatography-nanoelectrospray ionization-high-resolution tandem mass spectrometry technique to characterize 30 novel pyridyloxobutyl DNA phosphate adducts in calf thymus DNA (CT-DNA) treated with 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNKOAc, 2), a regiochemically activated form of NNK. A (15)N3-labeled internal standard was synthesized for one of the most abundant phosphate adducts, dCp[4-oxo-4-(3-pyridyl)butyl]dC (CpopC), and this standard was used to quantify CpopC and to estimate the levels of other adducts in the NNKOAc-treated CT-DNA. Formation of DNA phosphate adducts by NNK in vivo was further investigated in rats treated with NNK acutely (0.1 mmol/kg once daily for 4 days by subcutaneous injection) and chronically (5 ppm in drinking water for 10, 30, 50, and 70 weeks). This study provides the first comprehensive structural identification and quantitation of a panel of DNA phosphate adducts of a structurally complex carcinogen and chemical support for future mechanistic studies of tobacco carcinogenesis in humans.
doi: 10.1021/acs.chemrestox.5b00318
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ma B
      type: Person
      first name: Bin
      last name: Ma
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 2
    item: Villalta PW
      type: Person
      first name: Peter W
      last name: Villalta
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 3
    item: Zarth AT
      type: Person
      first name: Adam T
      last name: Zarth
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 4
    item: Kotandeniya D
      type: Person
      first name: Delshanee
      last name: Kotandeniya
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 5
    item: Upadhyaya P
      type: Person
      first name: Pramod
      last name: Upadhyaya
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 6
    item: Stepanov I
      type: Person
      first name: Irina
      last name: Stepanov
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 7
    item: Hecht SS
      type: Person
      first name: Stephen S
      last name: Hecht
      member of: Masonic Cancer Center, University of Minnesota , 2231 6th St SE, Minneapolis, Minnesota 55455, United States.
created: 2015-9-24T06:00
date last updated: 2025-01-17
issued: 2015-11-16
dp: 2015 Nov 16
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 11
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 2151
ending page: 9
has place of publication: United States
has primary subject term: D002273Q000633
has primary subject term: D018736
has primary subject term: D009602Q000633
has primary subject term: D010710Q000378
has subject term: D000818
has subject term: D004247Q000378
has subject term: D008168Q000378
has subject term: D008175
has subject term: D008297
has subject term: D011916
has subject term: D021241
has subject term: D053719
source: Chem Res Toxicol. 2015-11-16;28(11):2151-9.
volume: 28

Tobacco-alcohol optic neuropathy--clinical challenges in diagnosis.
pmid: 25713605
abstract: Part of the large group of nutritional and toxic optic neuropathies, tobacco-alcohol optic neuropathy is a disease often underdiagnosed or detected at a stage when the full recovery of vision is not possible. This article summarizes its signs and symptoms, describes the pathophysiological processes involved and provides the necessary information for diagnosis and treatment of the entity previously known as tobacco-alcohol amblyopia, reporting in the end, a challenging case along with its findings.
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Chiotoroiu SM
      type: Person
      first name: S M
      last name: Chiotoroiu
      member of: Nicolae Malaxa Clinical Hospital, Bucharest.
  slot:
    index: 2
    item: Noaghi M
      type: Person
      first name: M
      last name: Noaghi
      member of: Carol Davila University of Medicine and Pharmacy, Bucharest.
  slot:
    index: 3
    item: Stefaniu GI
      type: Person
      first name: G I
      last name: Stefaniu
      member of: Clinical Ophthalmological Emergency Hospital.
  slot:
    index: 4
    item: Secureanu FA
      type: Person
      first name: F A
      last name: Secureanu
      member of: Nicolae Malaxa Clinical Hospital, Bucharest.
  slot:
    index: 5
    item: Purcarea VL
      type: Person
      first name: V L
      last name: Purcarea
      member of: Carol Davila University of Medicine and Pharmacy, Bucharest.
  slot:
    index: 6
    item: Zemba M
      type: Person
      first name: M
      last name: Zemba
      member of: Carol Davila University of Medicine and Pharmacy, Bucharest.
created: 2015-2-26T06:00
date last updated: 2025-01-17
e ISSN: 1844-3117
has issn l: 1844-122X
issue: 4
has NLM journal title abbreviation: J Med Life
publication name: Journal of medicine and life
language: eng
has national library of medicine journal id: 101477617
derived from: NLM
starting page: 472
ending page: 6
has place of publication: Romania
has primary subject term: D000438Q000009
has primary subject term: D009901Q000175Q000209Q000503Q000628
has subject term: D005260
has subject term: D006801
has subject term: D008875
has subject term: D041623
has subject term: D058609
source: J Med Life. ;7(4):472-6.
volume: 7

Dual catalysis with magnetic chitosan: direct synthesis of cyclic carbonates from olefins with carbon dioxide using isobutyraldehyde as the sacrificial reductant.
pmid: 26055991
abstract: Chitosan coated magnetic nanoparticles were synthesized and used as a support for the immobilization of the cobalt(II) acetylacetonate complex [Co(acac)2] and quaternary triphenylphosphonium bromide [P(+)Ph3Br(-)] targeting -NH2 and -OH moieties located on the surface of chitosan. The synthesized material was used as a catalyst for one pot direct synthesis of cyclic carbonates from olefins via an oxidative carboxylation approach with carbon dioxide using isobutyraldehyde as the sacrificial reductant and molecular oxygen as the oxidant. After the reaction, the catalyst was recovered by applying an external magnet and reused for several runs without significant loss in catalytic activity and no leaching was observed during this course.
doi: 10.1039/c5dt01012h
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Kumar S
      type: Person
      first name: Subodh
      last name: Kumar
      member of: Chemical Sciences Division, CSIR-Indian Institute of Petroleum, Dehradun 248005, India. suman@iip.res.in.
  slot:
    index: 2
    item: Singhal N
      type: Person
      first name: Nikita
      last name: Singhal
  slot:
    index: 3
    item: Singh RK
      type: Person
      first name: Raj K
      last name: Singh
  slot:
    index: 4
    item: Gupta P
      type: Person
      first name: Piyush
      last name: Gupta
  slot:
    index: 5
    item: Singh R
      type: Person
      first name: Raghuvir
      last name: Singh
  slot:
    index: 6
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
created: 2015-6-10T06:00
date last updated: 2025-01-17
issued: 2015-07-14
dp: 2015 Jul 14
e ISSN: 1477-9234
has issn l: 1477-9226
issue: 26
has NLM journal title abbreviation: Dalton Trans
publication name: Dalton transactions (Cambridge, England : 2003)
language: eng
has national library of medicine journal id: 101176026
derived from: NLM
starting page: 11860
ending page: 6
has place of publication: England
has primary subject term: D000447Q000737
has primary subject term: D000475Q000737
has primary subject term: D002245Q000737
has primary subject term: D002254Q000138Q000737
has primary subject term: D048271Q000737
has primary subject term: D058185Q000737Q000648
has subject term: D002384
has subject term: D003500
source: Dalton Trans. 2015-07-14;44(26):11860-6.
volume: 44

Alcohol, Tobacco, Triggers, and Headache Disorders.
pmid: 26417623
doi: 10.1111/head.12619
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Tepper SJ
      type: Person
      first name: Stewart J
      last name: Tepper
created: 2015-9-30T06:00
date last updated: 2025-01-17
e ISSN: 1526-4610
has issn l: 0017-8748
issue: 7
has NLM journal title abbreviation: Headache
publication name: Headache
language: eng
has national library of medicine journal id: 2985091R
derived from: NLM
pg: 1027
has place of publication: United States
has primary subject term: D020773
has subject term: D000428
has subject term: D000438
has subject term: D006261
has subject term: D006801
has subject term: D015985
has subject term: D019966
source: Headache. ;55(7):1027.
volume: 55

Prenatal substance exposure: What predicts behavioral resilience by early adolescence?
pmid: 26076097
abstract: Understanding behavioral resilience among at-risk adolescents may guide public policy decisions and future programs. We examined factors predicting behavioral resilience following intrauterine substance exposure in a prospective longitudinal birth-cohort study of 136 early adolescents (ages 12.4-15.9 years) at risk for poor behavioral outcomes. We defined behavioral resilience as a composite measure of lack of early substance use initiation (before age 14), lack of risky sexual behavior, or lack of delinquency. Intrauterine substance exposures included in this analysis were cocaine, tobacco, alcohol, and marijuana. We recruited participants from Boston Medical Center as mother-infant dyads between 1990 and 1993. The majority of the sample was African American/Caribbean (88%) and 49% female. In bivariate analyses, none and lower intrauterine cocaine exposure level predicted resilience compared with higher cocaine exposure, but this effect was not found in an adjusted model. Instead, strict caregiver supervision (adjusted odds ratio [AOR] = 6.02, 95% confidence interval (CI) [1.90, 19.00], p = .002), lower violence exposure (AOR = 4.07, 95% CI [1.77, 9.38], p < .001), and absence of intrauterine tobacco exposure (AOR = 3.71, 95% CI [1.28, 10.74], p = .02) predicted behavioral resilience. In conclusion, caregiver supervision in early adolescence, lower violence exposure in childhood, and lack of intrauterine tobacco exposure predicted behavioral resilience among a cohort of early adolescents with significant social and environmental risk. Future interventions should work to enhance parental supervision as a way to mitigate the effects of adversity on high-risk groups of adolescents. (PsycINFO Database Record
rights: (c) 2015 APA, all rights reserved).
has PII: 2015-26085-002
doi: 10.1037/adb0000082
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Liebschutz JM
      type: Person
      first name: Jane M
      last name: Liebschutz
      member of: Clinical Addiction Research and Education Unit, Boston Medical Center.
  slot:
    index: 2
    item: Crooks D
      type: Person
      first name: Denise
      last name: Crooks
      member of: Department of Family Medicine, Boston Medical Center.
  slot:
    index: 3
    item: Rose-Jacobs R
      type: Person
      first name: Ruth
      last name: Rose-Jacobs
      member of: Department of Pediatrics, Boston Medical Center.
  slot:
    index: 4
    item: Cabral HJ
      type: Person
      first name: Howard J
      last name: Cabral
      member of: Department of Biostatistics, Boston University School of Public Health.
  slot:
    index: 5
    item: Heeren TC
      type: Person
      first name: Timothy C
      last name: Heeren
      member of: Data Coordinating Center, Boston University School of Public Health.
  slot:
    index: 6
    item: Gerteis J
      type: Person
      first name: Jessie
      last name: Gerteis
      member of: Abt Associates, Inc.
  slot:
    index: 7
    item: Appugliese DP
      type: Person
      first name: Danielle P
      last name: Appugliese
      member of: Data Coordinating Center, Boston University School of Public Health.
  slot:
    index: 8
    item: Heymann OD
      type: Person
      first name: Orlaith D
      last name: Heymann
      member of: Clinical Addiction Research and Education Unit, Boston Medical Center.
  slot:
    index: 9
    item: Lange AV
      type: Person
      first name: Allison V
      last name: Lange
      member of: Clinical Addiction Research and Education Unit, Boston Medical Center.
  slot:
    index: 10
    item: Frank DA
      type: Person
      first name: Deborah A
      last name: Frank
      member of: Department of Family Medicine, Boston Medical Center.
created: 2015-6-16T06:00
date last updated: 2025-01-17
issued: 2015-06
dp: 2015 Jun
e ISSN: 1939-1501
has issn l: 0893-164X
issue: 2
has NLM journal title abbreviation: Psychol Addict Behav
publication name: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
language: eng
has national library of medicine journal id: 8802734
derived from: NLM
starting page: 329
ending page: 37
has place of publication: United States
has primary subject term: D000294Q000502
has primary subject term: D002188Q000009
has primary subject term: D003042Q000009
has primary subject term: D000431Q000009
has primary subject term: D016487Q000523
has primary subject term: D011297Q000139
has primary subject term: D055500Q000187
has primary subject term: D014754Q000523
has subject term: D000293
has subject term: D002648
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D011247
has subject term: D008137
has subject term: D014028Q000009
source: Psychol Addict Behav. 2015-06;29(2):329-37.
volume: 29

Tobacco Stained Fingers and Its Association with Death and Hospital Admission: A Retrospective Cohort Study.
pmid: 26375287
abstract: Among smokers, the presence of tobacco stains on fingers has recently been associated with a high prevalence of tobacco related conditions and alcohol abuse.we aimed to explore tobacco stains as a marker of death and hospital readmission.Seventy-three smokers presenting tobacco-tar staining on their fingers and 70 control smokers were followed during a median of 5.5 years in a retrospective cohort study. We used the Kaplan-Meier survival analysis and the log-rank test to compare mortality and hospital readmission rates among smokers with and smokers without tobacco stains. Multivariable Cox models were used to adjust for confounding factors: age, gender, pack-year unit smoked, cancer, harmful alcohol use and diabetes. The number of hospital admissions was compared through a negative binomial regression and adjusted for the follow-up time, diabetes, and alcohol use.Forty-three patients with tobacco-stained fingers died compared to 26 control smokers (HR 1.6; 95%CI: 1.0 to 2.7; p 0.048). The association was not statistically significant after adjustment. Patients with tobacco-stained fingers needed a readmission earlier than smokers without stains (HR 2.1; 95%CI: 1.4 to 3.1; p<0.001), and more often (incidence rate ratio (IRR) 1.6; 95%CI: 1.1 to 2.1). Associations between stains and the first hospital readmission (HR 1.6; 95%CI: 1.0 to 2.5), and number of readmissions (IRR 1.5; 95%CI: 1.1 to 2.1) persisted after adjustment for confounding factors.Compared to other smokers, those presenting tobacco-stained fingers have a high unadjusted mortality rate and need early and frequent hospital readmission even when controlling for confounders.
has PII: PONE-D-15-17534
doi: 10.1371/journal.pone.0138211
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: John G
      type: Person
      first name: Gregor
      last name: John
      member of: Department of Internal Medicine, Hôpital neuchâtelois, 2300, La Chaux-de-Fonds, Switzerland; Department of Internal medicine geriatrics and rehabilitation, Geneva University Hospitals (HUG), Gabrielle-Perret-Gentil 4, CH-1205, Geneva, Switzerland.
  slot:
    index: 2
    item: Louis C
      type: Person
      first name: Céline
      last name: Louis
      member of: Department of Internal Medicine, Hôpital neuchâtelois, 2300, La Chaux-de-Fonds, Switzerland.
  slot:
    index: 3
    item: Berner A
      type: Person
      first name: Amandine
      last name: Berner
      member of: Department of Internal Medicine, Hôpital neuchâtelois, 2300, La Chaux-de-Fonds, Switzerland.
  slot:
    index: 4
    item: Genné D
      type: Person
      first name: Daniel
      last name: Genné
      member of: Department of Internal Medicine, Centre Hospitalier de Bienne, 2501, Bienne, Switzerland.
created: 2015-9-17T06:00
date last updated: 2025-01-17
issued: 2015
dp: 2015
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 9
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0138211
has place of publication: United States
has primary subject term: D004396Q000009
has primary subject term: D010359Q000706
has primary subject term: D014029Q000150Q000401
has subject term: D000368
has subject term: D000428Q000453
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D015995
has subject term: D012189
has subject term: D012307
has subject term: D015996
has subject term: D013557Q000453
has subject term: D013997
source: PLoS One. 2015;10(9):e0138211.
volume: 10

p53 Expression Helps Identify High Risk Oral Tongue Pre- malignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases.
pmid: 26838208
abstract: Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cancer subtype with a maximum propensity for regional spread. Our objective was to study if p53 expression might have any correlation with aggressive patterns of invasion within oral tongue cancers as well as with the histologically identified degree of oral tongue dysplasia. p53 immunoexpression was studied using immunohistochemistry in early staged OTSCCs (n=155), oral tongue dysplasias, (n=29) and oral tongue normal specimens (n=10) and evaluated for correlations with histological and clinicopathological parameters. Our study (n=194) showed a pattern of p53 expression increasing with different grades of tongue dysplasia to different grades of invasive OTSCC (p=0.000). Among the OTSCC tumours, positive p53 expression was seen in 43.2% (67/155) and a higher p53 labelling index was significantly associated with increased Bryne's grade of the tumour invasive front (p=0.039) and increased tumour depth (p=0.018). Among the OTSCC patients with tobacco habits, (n=91), a higher p53 labelling index was significantly associated with increased risk of local recurrence (p=0.025) and with lymphovascular space involvement (p=0.014). Evaluation of p53 through varying degrees of dysplasia to oral tongue cancer indicates that p53 expression is linked to aggressive features of oral tongue cancers and tongue precancers entailing a closer monitoring in positive cases. Among the OTSCCs, p53 expression is associated with tumour aggressiveness correlating with increased grading of invasive tumour front and tumour depth.
doi: 10.7314/apjcp.2016.17.1.189
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Viveka TS
      type: Person
      first name: Thangaraj Soundara
      last name: Viveka
      member of: Department of Preventive Oncology, Cancer Institute (WIA), Adyar, India E-mail : vijiciwia@gmail.com.
  slot:
    index: 2
    item: Shyamsundar V
      type: Person
      first name: Vidyarani
      last name: Shyamsundar
  slot:
    index: 3
    item: Krishnamurthy A
      type: Person
      first name: Arvind
      last name: Krishnamurthy
  slot:
    index: 4
    item: Ramani P
      type: Person
      first name: Pratibha
      last name: Ramani
  slot:
    index: 5
    item: Ramshankar V
      type: Person
      first name: Vijayalakshmi
      last name: Ramshankar
created: 2016-2-4T06:00
date last updated: 2025-01-17
issued: 2016
dp: 2016
e ISSN: 2476-762X
has issn l: 1513-7368
issue: 1
has NLM journal title abbreviation: Asian Pac J Cancer Prev
publication name: Asian Pacific journal of cancer prevention : APJCP
language: eng
has national library of medicine journal id: 101130625
derived from: NLM
starting page: 189
ending page: 95
has place of publication: Thailand
has primary subject term: D002294Q000378Q000473
has primary subject term: D009062Q000378Q000473
has primary subject term: D011230Q000378Q000473
has primary subject term: D014062Q000378Q000473
has primary subject term: D016159Q000378
has subject term: D000328
has subject term: D000368
has subject term: D000369
has subject term: D005260
has subject term: D006184
has subject term: D006801
has subject term: D006965Q000378Q000473
has subject term: D008297
has subject term: D008875
has subject term: D012306
has subject term: D055815
source: Asian Pac J Cancer Prev. 2016;17(1):189-95.
volume: 17

Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry.
pmid: 26825008
abstract: Nicotine is the most abundant alkaloid in tobacco accounting for 95% of the alkaloid content. There are also several minor tobacco alkaloids; among these are nornicotine, anatabine, and anabasine. We developed and applied a 96 well plate-based capillary LC-tandem mass spectrometry method for the analysis of nornicotine, anatabine, and anabasine in urine. The method was validated with regard to accuracy and precision. Anabasine was quantifiable to low levels with a limit of quantitation (LOQ) of 0.2 ng/mL even when nicotine, which is isobaric, is present at concentrations >2500-fold higher than anabasine. This attribute of the method is important since anatabine and anabasine in urine have been proposed as biomarkers of tobacco use for individuals using nicotine replacement therapies. In the present study, we analyzed the three minor tobacco alkaloids in urine from 827 smokers with a wide range of tobacco exposures. Nornicotine (LOQ 0.6 ng/mL) was detected in all samples, and anatabine (LOQ, 0.15 ng/mL) and anabasine were detected in 97.7% of the samples. The median urinary concentrations of nornicotine, anatabine, and anabasine were 98.9, 4.02, and 5.53 ng/mL. Total nicotine equivalents (TNE) were well correlated with anatabine (r(2) = 0.714) and anabasine (r(2) = 0.760). TNE was most highly correlated with nornicotine, which is also a metabolite of nicotine. Urine samples from a subset of subjects (n = 110) were analyzed for the presence of glucuronide conjugates by quantifying any increase in anatabine and anabasine concentrations after β-glucuronidase treatment. The median ratio of the glucuronidated to free anatabine was 0.74 (range, 0.1 to 10.9), and the median ratio of glucuronidated to free anabasine was 0.3 (range, 0.1 to 2.9). To our knowledge, this is the largest population of smokers for whom the urinary concentrations of these three tobacco alkaloids has been reported.
doi: 10.1021/acs.chemrestox.5b00521
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: von Weymarn LB
      type: Person
      first name: Linda B
      last name: von Weymarn
      member of: Department of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  slot:
    index: 2
    item: Thomson NM
      type: Person
      first name: Nicole M
      last name: Thomson
      member of: Department of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  slot:
    index: 3
    item: Donny EC
      type: Person
      first name: Eric C
      last name: Donny
      member of: Department of Psychology, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
  slot:
    index: 4
    item: Hatsukami DK
      type: Person
      first name: Dorothy K
      last name: Hatsukami
      member of: Masonic Cancer Center and Department of Psychiatry, University of Minnesota , Minneapolis, Minnesota 55455, United States.
  slot:
    index: 5
    item: Murphy SE
      type: Person
      first name: Sharon E
      last name: Murphy
      member of: Department of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota , Minneapolis, Minnesota 55455, United States.
created: 2016-1-31T06:00
date last updated: 2025-01-17
issued: 2016-03-21
dp: 2016 Mar 21
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 3
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 390
ending page: 7
has place of publication: United States
has primary subject term: D000470Q000652
has primary subject term: D000691Q000652
has primary subject term: D009538Q000031Q000652
has primary subject term: D011725Q000652
has primary subject term: D012907Q000652
has subject term: D000293
has subject term: D002851
has subject term: D006801
has subject term: D015394
has subject term: D053719
source: Chem Res Toxicol. 2016-03-21;29(3):390-7.
volume: 29

Putting tobacco harm reduction in perspective: is it a viable alternative?
pmid: 26997010
has PII: IndianJMedRes_2016_143_1_25_178583
doi: 10.4103/0971-5916.178583
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Jhanjee S
      type: Person
      first name: Sonali
      last name: Jhanjee
      member of: National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi 110 029, India.
created: 2016-3-22T06:00
date last updated: 2025-01-17
issued: 2016-01
dp: 2016 Jan
ISSN: 0971-5916
has issn l: 0971-5916
issue: 1
has NLM journal title abbreviation: Indian J Med Res
publication name: The Indian journal of medical research
language: eng
has national library of medicine journal id: 0374701
derived from: NLM
starting page: 25
ending page: 9
has place of publication: India
has primary subject term: D016540
has primary subject term: D019460
has subject term: D040261
has subject term: D006801
has subject term: D009602Q000737
source: Indian J Med Res. 2016-01;143(1):25-9.
volume: 143

Refining the Understanding of the Effects of Prenatal Methamphetamine and Tobacco Exposure on the Developing Brain.
pmid: 27829080
has PII: 2579937
doi: 10.1001/jamapsychiatry.2016.2845
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Roos A
      type: Person
      first name: Annerine
      last name: Roos
      member of: Stellenbosch University/University of Cape Town Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
  slot:
    index: 2
    item: Donald KA
      type: Person
      first name: Kirsten Ann
      last name: Donald
      member of: Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and University of Cape Town, Cape Town, South Africa.
created: 2016-11-10T06:00
date last updated: 2025-01-17
issued: 2016-12-01
dp: 2016 12 01
e ISSN: 2168-6238
has issn l: 2168-622X
issue: 12
has NLM journal title abbreviation: JAMA Psychiatry
publication name: JAMA psychiatry
language: eng
has national library of medicine journal id: 101589550
derived from: NLM
starting page: 1228
ending page: 1229
has place of publication: United States
has primary subject term: D008694
has subject term: D006801
has subject term: D001921
has subject term: D000697
has subject term: D011297
has subject term: D014028
source: JAMA Psychiatry. 2016-12-01;73(12):1228-1229.
volume: 73

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines.
pmid: 27989137
abstract: N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are carcinogenic tobacco-specific nitrosamines believed to play a vital role in the initiation of tobacco-related cancers. For their carcinogenicities to be exhibited, both NNN and NNK must be metabolically activated by cytochrome P450s, specifically P450 2A6 and P450 2A13, respectively. Prior research has focused on α-hydroxylation, which leads to the formation of several DNA adducts that have been identified and quantified in vivo. However, some studies indicate that P450s can retain substrates within their active sites and perform processive oxidation. For nitrosamines, this would oxidize the highly unstable α-hydroxynitrosamines to potentially more stable nitrosamides, which could also alkylate DNA. Thus, we hypothesized that both NNN and NNK are processively oxidized in vitro to nitrosamides by P450 2A6 and P450 2A13, respectively. To test this hypothesis, we synthesized the NNN- and NNK-derived nitrosamides, determined their half-lives at pH 7.4 and 37 °C, and monitored for nitrosamide formation in an in vitro P450 system with product analysis by LC/NSI+-HRMS/MS. Half-lives of the nitrosamides were determined by HPLC-UV and ranged from 7-35 min, which is more than 40 times longer than the corresponding α-hydroxynitrosamines. Incubation of NNN in the P450 2A6 system resulted in the formation of the nitrosamide N'-nitrosonorcotinine (NNC) at low levels. Similarly, the nitrosamide 4-(methylnitrosamino)-1-(3-pyridyl)-1,4-butanedione (CH2-oxo-NNK) was detected in low amounts in the incubation of NNK with the P450 2A13 system. The other possible NNK-derived nitrosamide, 4-(nitrosoformamido)-1-(3-pyridyl)-1-butanone (CH3-oxo-NNK), was not observed in the P450 2A13 reactions. CH2-oxo-NNK readily formed O6meGua in reactions with dGuo and calf thymus DNA. These results demonstrate that NNC and CH2-oxo-NNK are novel metabolites of NNN and NNK, respectively. Though low-forming, their incr[cell cut: 2287 characters, first 2000 kept]
doi: 10.1021/acs.chemrestox.6b00384
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Carlson ES
      type: Person
      first name: Erik S
      last name: Carlson
      member of: Masonic Cancer Center, University of Minnesota , 2231 Sixth Street SE, 2-210 CCRB, Minneapolis, Minnesota 55455, United States.Department of Pharmacology, University of Minnesota Medical School , 321 Church Street SE, 6-120 Jackson Hall, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 2
    item: Upadhyaya P
      type: Person
      first name: Pramod
      last name: Upadhyaya
      member of: Masonic Cancer Center, University of Minnesota , 2231 Sixth Street SE, 2-210 CCRB, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 3
    item: Hecht SS
      type: Person
      first name: Stephen S
      last name: Hecht
      member of: Masonic Cancer Center, University of Minnesota , 2231 Sixth Street SE, 2-210 CCRB, Minneapolis, Minnesota 55455, United States.
created: 2016-12-19T06:00
date last updated: 2025-01-17
issued: 2016-12-19
dp: 2016 12 19
created: 2016-12-20T06:00
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 12
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 2194
ending page: 2205
has place of publication: United States
has primary subject term: D003577Q000378
has primary subject term: D009602Q000378
has primary subject term: D009603Q000378
has subject term: D000818
has subject term: D066241
has subject term: D013058
has subject term: D066244
source: Chem Res Toxicol. 2016-12-19;29(12):2194-2205.
volume: 29

Defending Against Advanced Persistent Threats Using Game-Theory.
pmid: 28045922
abstract: Advanced persistent threats (APT) combine a variety of different attack forms ranging from social engineering to technical exploits. The diversity and usual stealthiness of APT turns them into a central problem of contemporary practical system security, since information on attacks, the current system status or the attacker's incentives is often vague, uncertain and in many cases even unavailable. Game theory is a natural approach to model the conflict between the attacker and the defender, and this work investigates a generalized class of matrix games as a risk mitigation tool for an advanced persistent threat (APT) defense. Unlike standard game and decision theory, our model is tailored to capture and handle the full uncertainty that is immanent to APTs, such as disagreement among qualitative expert risk assessments, unknown adversarial incentives and uncertainty about the current system state (in terms of how deeply the attacker may have penetrated into the system's protective shells already). Practically, game-theoretic APT models can be derived straightforwardly from topological vulnerability analysis, together with risk assessments as they are done in common risk management standards like the ISO 31000 family. Theoretically, these models come with different properties than classical game theoretic models, whose technical solution presented in this work may be of independent interest.
has PII: PONE-D-16-34212
doi: 10.1371/journal.pone.0168675
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Rass S
      type: Person
      first name: Stefan
      last name: Rass
      member of: Universität Klagenfurt, Institute of Applied Informatics, Klagenfurt, Austria.
  slot:
    index: 2
    item: König S
      type: Person
      first name: Sandra
      last name: König
      member of: Austrian Institute of Technology, Safety & Security Department, Klagenfurt, Austria.
  slot:
    index: 3
    item: Schauer S
      type: Person
      first name: Stefan
      last name: Schauer
      member of: Austrian Institute of Technology, Safety & Security Department, Klagenfurt, Austria.
created: 2017-1-4T06:00
date last updated: 2025-01-17
issued: 2017
dp: 2017
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 1
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0168675
has place of publication: United States
has primary subject term: D016494
has primary subject term: D003199
has primary subject term: D005716
has primary subject term: D012308
has primary subject term: D012984
has subject term: D003661
has subject term: D006801
has subject term: D008962
has subject term: D011336
has subject term: D018570
has subject term: D013269
has subject term: D035501
source: PLoS One. 2017;12(1):e0168675.
volume: 12

Tobacco bans and smokers' autonomy.
pmid: 27003421
has PII: medethics-2016-103469
doi: 10.1136/medethics-2016-103469
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Halliday D
      type: Person
      first name: Daniel
      last name: Halliday
created: 2016-3-24T06:00
date last updated: 2025-01-17
issued: 2016-05
dp: 2016 05
created: 2016-3-23T06:00
e ISSN: 1473-4257
has issn l: 0306-6800
issue: 5
has NLM journal title abbreviation: J Med Ethics
publication name: Journal of medical ethics
language: eng
has national library of medicine journal id: 7513619
derived from: NLM
starting page: 303
ending page: 4
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000074285
has subject term: D006801
has subject term: D016540
has subject term: D014028
has subject term: D014029
source: J Med Ethics. 2016-05;42(5):303-4.
volume: 42

Assessment of tobacco, alcohol and cannabinoid metabolites in 645 meconium samples of newborns compared to maternal self-reports.
pmid: 28237885
abstract: Prenatal psychoactive substance exposure has significant impact on neonatal health and child development and the development of reliable biomarkers is critical. Meconium presents several advantages for detecting prenatal exposure to psychoactive substances, as it is easy to collect and provides a broad time frame of exposure (third trimester). The aim of our study was to compare the prevalence of alcohol, tobacco and/or cannabis use during the third trimester of pregnancy (using maternal self-reports) with the results of meconium testing of their metabolites in newborns (cotinine, ethyl-glucuronide (EtG) and cannabinoid metabolites). Among all deliveries (993) that occurred in all maternities in Rouen (Normandy) during a defined time period (5 consecutive weeks in August, 2010 and August, 2011), 724 mothers were included and 645 meconium samples were collected. Maternal self-reports, using the Addiction Severity Index (5th edition), and meconium samples were collected within 72 h of delivery. Cotinine detection appears highly correlated to maternal self-reports (Kappa value: 0.79; [95%CI: 0.73-0.85]). Moreover, detection in meconium seems more accurate in the prediction of neonatal consequences of prenatal tobacco exposure as compared to maternal self-reports. In contrast, we have found a lower concordance between maternal self-reports and meconium testing for EtG and cannabinoid metabolites (Kappa value: 0.13; [95%CI: 0.04-0.22] and: 0.30; [95%CI: -0.03-0.63], respectively); however the total number of EtG- and cannabinoid-positive meconium samples was small. Interestingly, meconium samples with the highest levels of EtG mainly corresponded to negative maternal self-reports. Fetal exposure to alcohol, tobacco or cannabis may also considerably differ as displayed in our pairs of dizygotic twins. Finally, a polyconsumption of these psychoactive substances was not frequently observed according to meconium testing. In conclusion, cotinine detection appears as a valuabl[cell cut: 2216 characters, first 2000 kept]
rights: Copyright © 2017 Elsevier Ltd. All rights reserved.
has PII: S0022-3956(16)30793-2
doi: 10.1016/j.jpsychires.2017.02.012
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Lamy S
      type: Person
      first name: Sandrine
      last name: Lamy
      member of: Department of Addictology, Ramsay- General de Santé, SSR Petit Colmoulins, Harfleur, France; University Hospital Cochin (site Tarnier), University Sorbonne Paris-Cité (Paris V), Faculty of Medicine Paris Descartes, INSERM U894, Centre Psychiatry and Neurosciences, Paris, France. Electronic address: sandrine.lamy74@gmail.com.
  slot:
    index: 2
    item: Hennart B
      type: Person
      first name: Benjamin
      last name: Hennart
      member of: CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille, France. Electronic address: benjamin.hennart@chru-lille.fr.
  slot:
    index: 3
    item: Houivet E
      type: Person
      first name: Estelle
      last name: Houivet
      member of: Department of Biostatistics, University Hospital Rouen, Centre d'Investigation Clinique et de Ressources Biologiques, INSERM CIC-CRB, 1404 Rouen, France. Electronic address: Estelle.Houivet@chu-rouen.fr.
  slot:
    index: 4
    item: Dulaurent S
      type: Person
      first name: Sylvain
      last name: Dulaurent
      member of: Laboratoire de Pharmacologie, Toxicologie et Pharmacovigilance, Hôpital Dupuytren, CHU de Limoges, France. Electronic address: sylvain.dulaurent@unilim.fr.
  slot:
    index: 5
    item: Delavenne H
      type: Person
      first name: Heloise
      last name: Delavenne
      member of: Department of Psychiatry, Faculty of Medicine, Federal University of Minas Gerais, Brazil. Electronic address: heloise.delavenne@gmail.com.
  slot:
    index: 6
    item: Benichou J
      type: Person
      first name: Jacques
      last name: Benichou
      member of: Department of Biostatistics, University Hospital Rouen, Centre d'Investigation Clinique et de Ressources Biologiques, INSERM CIC-CRB, 1404 Rouen, France. Electronic address: Jacques.Benichou@chu-rouen.fr.
  slot:
    index: 7
    item: Allorge D
      type: Person
      first name: Delphine
      last name: Allorge
      member of: CHU Lille, Service de Toxicologie-Génopathies, F-59000 Lille, France; Univ.Lille, EA 4483-IMPECS- IMPact de l'Environnement Chimique sur la Santé humaine, F-59000 Lille, France. Electronic address: delphine.allorge@chru-lille.fr.
  slot:
    index: 8
    item: Marret S
      type: Person
      first name: Stéphane
      last name: Marret
      member of: Department of Neonatal Medicine-Neuropediatrics, Rouen University Hospital and INSERM U 1245, Neovasc Team, Perinatal neurological handicap and Neuroprotection, Institute of Biomedical Research and Innovation, School of Medicine, Normandy University, France. Electronic address: stephane.marret@chu-rouen.fr.
  slot:
    index: 9
    item: Thibaut F
      type: Person
      first name: Florence
      last name: Thibaut
      member of: University Hospital Cochin (site Tarnier), University Sorbonne Paris-Cité (Paris V), Faculty of Medicine Paris Descartes, INSERM U894, Centre Psychiatry and Neurosciences, Paris, France. Electronic address: florence.thibaut@aphp.fr.
creator: Perinatal network of Upper-Normandy
created: 2017-2-27T06:00
date last updated: 2025-01-17
issued: 2017-07
dp: 2017 07
e ISSN: 1879-1379
has issn l: 0022-3956
has NLM journal title abbreviation: J Psychiatr Res
publication name: Journal of psychiatric research
language: eng
has national library of medicine journal id: 0376331
derived from: NLM
starting page: 86
ending page: 93
has place of publication: England
has primary subject term: D002186Q000009Q000378
has primary subject term: D000431Q000009
has primary subject term: D018811Q000009
has primary subject term: D008470Q000378
has primary subject term: D057566
has subject term: D005260
has subject term: D006801
has subject term: D007231
has subject term: D008297
has subject term: D011247
has subject term: D014028Q000032
has subject term: D011297Q000378
source: J Psychiatr Res. 2017-07;90():86-93.
volume: 90

Opium use during pregnancy and risk of preterm delivery: A population-based cohort study.
pmid: 28448546
abstract: Use of narcotic or recreational drugs has been associated with adverse pregnancy outcomes such as preterm delivery. However, the associations might be confounded by other factors related to high-risk behaviours. This is the first study to investigate the association between traditional opium use during pregnancy and risk of preterm delivery.We performed a population-based cohort study in the rural areas of the Golestan province, Iran between 2008 and 2010. We randomly selected 920 women who used (usually smoked) opium during pregnancy and 920 women who did not. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations between the opium use during pregnancy and preterm delivery and adjustment was made for potential confounding factors. This study shows compared with non-use of opium and tobacco, use of only opium during pregnancy was associated with an increased risk of preterm delivery (OR = 1.56; 95% CI 1.05-2.32), and the risk was more than two-fold increased among dual users of opium and tobacco (OR = 2.31; 95% CI 1.37-3.90). We observed that opium use only was associated with a doubled risk for preterm caesarean delivery (OR = 2.05; 95% CI 1.10-3.82) but not for preterm vaginal delivery (OR = 1.25; 95% CI 0.75-2.07). Dual use of opium and tobacco was associated with a substantially increased risk of vaginal preterm delivery (OR = 2.58; 95% CI 1.41-4.71).Opium use during pregnancy among non-tobacco smokers is associated with an increased risk of preterm caesarean delivery, indicating an increased risk of a compromised foetus before or during labour. Women who use both opium and smoked during pregnancy have an increased risk of preterm vaginal delivery, indicating an increased risk of spontaneous preterm delivery.
has PII: PONE-D-16-11828
doi: 10.1371/journal.pone.0176588
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Maghsoudlou S
      type: Person
      first name: Siavash
      last name: Maghsoudlou
      member of: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden.
  slot:
    index: 2
    item: Cnattingius S
      type: Person
      first name: Sven
      last name: Cnattingius
      member of: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden.
  slot:
    index: 3
    item: Montgomery S
      type: Person
      first name: Scott
      last name: Montgomery
      member of: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden.Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.Department of Epidemiology and Public Health, University College London, United Kingdom.
  slot:
    index: 4
    item: Aarabi M
      type: Person
      first name: Mohsen
      last name: Aarabi
      member of: Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  slot:
    index: 5
    item: Semnani S
      type: Person
      first name: Shahriar
      last name: Semnani
      member of: Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
  slot:
    index: 6
    item: Wikström AK
      type: Person
      first name: Anna-Karin
      last name: Wikström
      member of: Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Solna, Sweden.Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  slot:
    index: 7
    item: Bahmanyar S
      type: Person
      first name: Shahram
      last name: Bahmanyar
      member of: Clinical Epidemiology Unit & Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institute, Solna, Sweden.
created: 2017-4-28T06:00
date last updated: 2025-01-17
issued: 2017
dp: 2017
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 4
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0176588
has place of publication: United States
has primary subject term: D018811
has primary subject term: D009892Q000633
has primary subject term: D047928Q000139
has subject term: D000328
has subject term: D015331
has subject term: D005260
has subject term: D006801
has subject term: D007492
has subject term: D016015
has subject term: D016017
has subject term: D011247
has subject term: D012307
has subject term: D012309
has subject term: D012959
source: PLoS One. 2017;12(4):e0176588.
volume: 12

Documenting the emergence of electronic nicotine delivery systems as a disruptive technology in nicotine and tobacco science.
pmid: 27816664
abstract: The emergence of electronic nicotine delivery systems (ENDS, or e-cigarettes ) has resulted in nicotine and tobacco scientists committing increased resources to studying these products. Despite this surge of research on various topics related to e-cigarettes, it is important to characterize the evolving e-cigarette research landscape as a way to identify important future research directions. The purpose of this review was to broadly categorize published scholarly work on e-cigarettes using a structured, multi-level coding scheme.A systematic literature search was conducted to collect articles on e-cigarettes that were published in peer-reviewed journals from 2006 through 2014. Studies were classified through 3 coding waves. Articles were first divided into research reports, literature reviews and opinions/editorials. Research reports were further categorized to determine the proportion of these studies using human participants. Finally, human studies were classified based on their methodologies: descriptive, predictive, explanatory, and intervention.Research reports (n=224) and opinions/editorials (n=248) were published at similar rates during this time period. All types of articles showed exponential rates of increase in more recent years. 76.4% of human research studies were descriptive in nature, with very little research employing experimental (6.8%) or intervention-based methodologies (5.4%).This review reinforces the idea that e-cigarettes are a disruptive technology exerting substantial influence on nicotine and tobacco science. This review also suggests that opinions on e-cigarettes may be outpacing our scientific understanding of these devices. Our findings highlight the need for more e-cigarette research involving experimental, intervention, and longitudinal designs.
rights: Copyright Â© 2016 Elsevier Ltd. All rights reserved.
has PII: S0306-4603(16)30377-X
doi: 10.1016/j.addbeh.2016.10.021
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Correa JB
      type: Person
      first name: John B
      last name: Correa
      member of: Department of Psychology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA; Tobacco Research & Intervention Program, H. Lee Moffitt Cancer Center, 4115 East Fowler Avenue, Tampa, FL 33617, USA.
  slot:
    index: 2
    item: Ariel I
      type: Person
      first name: Idan
      last name: Ariel
      member of: Department of Psychology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA; Tobacco Research & Intervention Program, H. Lee Moffitt Cancer Center, 4115 East Fowler Avenue, Tampa, FL 33617, USA.
  slot:
    index: 3
    item: Menzie NS
      type: Person
      first name: Nicole S
      last name: Menzie
      member of: Department of Psychology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA; Tobacco Research & Intervention Program, H. Lee Moffitt Cancer Center, 4115 East Fowler Avenue, Tampa, FL 33617, USA.
  slot:
    index: 4
    item: Brandon TH
      type: Person
      first name: Thomas H
      last name: Brandon
      member of: Department of Psychology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA; Tobacco Research & Intervention Program, H. Lee Moffitt Cancer Center, 4115 East Fowler Avenue, Tampa, FL 33617, USA. Electronic address: thomas.brandon@moffitt.org.
created: 2016-11-7T06:00
date last updated: 2025-01-17
issued: 2017-02
dp: 2017 02
e ISSN: 1873-6327
has issn l: 0306-4603
has NLM journal title abbreviation: Addict Behav
publication name: Addictive behaviors
language: eng
has national library of medicine journal id: 7603486
derived from: NLM
starting page: 179
ending page: 184
has place of publication: England
has primary subject term: D066300
has primary subject term: D009538
has primary subject term: D012106
has primary subject term: D013672
has subject term: D006801
has subject term: D012586
source: Addict Behav. 2017-02;65():179-184.
volume: 65

Efficient removal of amoxicillin and paracetamol from aqueous solutions using magnetic activated carbon.
pmid: 28064396
abstract: Activated carbon (AC)/CoFe2O4 nanocomposites, MAC-1 and MAC-2, were prepared by a simple pyrolytic method using a mixture of iron(III)/cobalt(II) benzoates and iron(III)/cobalt(II) oxalates, respectively, and were used as efficient adsorbents for the removal of amoxicillin (AMX) and paracetamol (PCT) of aqueous effluents. The synthesized nanocomposites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and transmission electron microscopy (TEM). The sizes of cobalt ferrite nanoparticles formed from benzoates of iron(III)/cobalt(II) and oxalates of iron(III)/cobalt(II) precursors were in the ranges of 5-80 and 6-27 nm, respectively. The saturation magnetization (M s), remanence (M r) and coercivity (H c) of the MAC-2 nanocomposites were found to be 3.07 emu g-1, 1.36 emu g-1 and 762.49 Oe; for MAC-1, they were 0.2989 emu g-1, 0.0466 emu g-1 and 456.82 Oe. The adsorption kinetics and isotherm studies were investigated, and the results showed that the as-prepared nanocomposites MAC-1 and MAC-2 could be utilized as an efficient, magnetically separable adsorbent for environmental cleanup. The maximum sorption capacities obtained were 280.9 and 444.2 mg g-1 of AMX for MAC-1 and MAC-2, respectively, and 215.1 and 399.9 mg g-1 of PCT using MAC-1 and MAC-2, respectively. Both adsorbents were successfully used for simulated hospital effluents, removing at least 93.00 and 96.77% for MAC-1 and MAC-2, respectively, of a mixture of nine pharmaceuticals with high concentrations of sugars, organic components and saline concentrations.
has PII: 10.1007/s11356-016-8304-7
doi: 10.1007/s11356-016-8304-7
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Saucier C
      type: Person
      first name: Caroline
      last name: Saucier
      member of: Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  slot:
    index: 2
    item: Karthickeyan P
      type: Person
      first name: P
      last name: Karthickeyan
      member of: Department of Chemistry, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, 641029, India.
  slot:
    index: 3
    item: Ranjithkumar V
      type: Person
      first name: V
      last name: Ranjithkumar
      member of: Department of Chemistry, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, 641029, India.
  slot:
    index: 4
    item: Lima EC
      type: Person
      first name: Eder C
      last name: Lima
      member of: Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  slot:
    index: 5
    item: Dos Reis GS
      type: Person
      first name: Glaydson S
      last name: Dos Reis
      member of: Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. glaydsonambiental@mail.com.Department of Metallurgy, Federal University of Rio Grande do Sul (UFRGS), Engineering School, Av. Bento Gonçalves, 9500, Agronomia, Porto Alegre, 91501-970, Brazil. glaydsonambiental@mail.com.
  slot:
    index: 6
    item: de Brum IAS
      type: Person
      first name: Irineu A S
      last name: de Brum
      member of: Department of Metallurgy, Federal University of Rio Grande do Sul (UFRGS), Engineering School, Av. Bento Gonçalves, 9500, Agronomia, Porto Alegre, 91501-970, Brazil.
created: 2017-1-9T06:00
date last updated: 2025-01-17
issued: 2017-02
dp: 2017 Feb
e ISSN: 1614-7499
has issn l: 0944-1344
issue: 6
has NLM journal title abbreviation: Environ Sci Pollut Res Int
publication name: Environmental science and pollution research international
language: eng
has national library of medicine journal id: 9441769
derived from: NLM
starting page: 5918
ending page: 5932
has place of publication: Germany
has primary subject term: D000082Q000302
has primary subject term: D000658Q000302
has primary subject term: D002606Q000737
has primary subject term: D014874Q000302
has subject term: D000327
has subject term: D003035Q000737
has subject term: D005290Q000737
has subject term: D007700
has subject term: D008855
has subject term: D046529
has subject term: D053761Q000737
has subject term: D012996
has subject term: D013052
has subject term: D017550
source: Environ Sci Pollut Res Int. 2017-02;24(6):5918-5932.
volume: 24

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.
pmid: 28459200
abstract: The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in Argentine patients.
doi: 10.1177/1010428317699113
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Zarate AM
      type: Person
      first name: Ana Maria
      last name: Zarate
      member of: 1 Departamento de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 2
    item: Don J
      type: Person
      first name: Julieta
      last name: Don
      member of: 1 Departamento de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 3
    item: Secchi D
      type: Person
      first name: Dante
      last name: Secchi
      member of: 2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 4
    item: Carrica A
      type: Person
      first name: Andres
      last name: Carrica
      member of: 2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 5
    item: Galindez Costa F
      type: Person
      first name: Fernanda
      last name: Galindez Costa
      member of: 2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 6
    item: Panico R
      type: Person
      first name: Rene
      last name: Panico
      member of: 2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 7
    item: Brusa M
      type: Person
      first name: Martin
      last name: Brusa
      member of: 2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 8
    item: Barra JL
      type: Person
      first name: José Luis
      last name: Barra
      member of: 3 Facultad de Ciencias Químicas, CIQUIBIC-CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 9
    item: Brunotto M
      type: Person
      first name: Mabel
      last name: Brunotto
      member of: 2 Departamento de Patología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
created: 2017-5-2T06:00
date last updated: 2025-01-17
issued: 2017-05
dp: 2017 May
e ISSN: 1423-0380
has issn l: 1010-4283
issue: 5
has NLM journal title abbreviation: Tumour Biol
publication name: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
language: eng
has national library of medicine journal id: 8409922
derived from: NLM
pg: 1010428317699113
has place of publication: Netherlands
has primary subject term: D020022
has primary subject term: D017676Q000453Q000235Q000473
has primary subject term: D009062Q000453Q000235Q000473
has primary subject term: D016159Q000235
has subject term: D000328
has subject term: D000368
has subject term: D000428Q000009
has subject term: D001118
has subject term: D063646Q000235
has subject term: D003062
has subject term: D005260
has subject term: D056726
has subject term: D005838
has subject term: D006801
has subject term: D007972Q000453Q000235Q000473
has subject term: D008297
has subject term: D008875
has subject term: D009061Q000473
has subject term: D020641Q000235
has subject term: D012307
has subject term: D012737
source: Tumour Biol. 2017-05;39(5):1010428317699113.
volume: 39

Assessment of relationship of ABO blood groups among tobacco induced oral cancer patients of Kanpur Population, Uttar Pradesh.
pmid: 29161780
abstract: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer.The present study was conducted at various cancer hospitals in Kanpur. The study samples comprised 100 oral cancer patients and 50 controls with tobacco chewing habit. The information regarding the socio demographic profile, history on tobacco habits, type of oral cancer and ABO blood group profile was obtained from the case sheets of the patients.The frequency of squamous cell carcinoma was significantly higher in men (78%) than women (22%) and mostly found in the age range of 45-65 years and also consuming chewing type of tobacco. It was found that out of 100 patients, 53 were of blood group B+ve, 28 of O +ve, 16 of A+ve and 3 had the blood group AB+ve. The high potential risk of developing OSCC was more in B+ve blood group (1.96 times), and relative frequency (%) in blood group O+ve (1.64 times) than in the control group Among locations of oral cancers, squamous cell carcinoma of tongue (25%) and buccal mucosa (15%) was more common in B+ve and Carcinoma of floor of mouth (11%) was more common in O+ve blood group cases. It was found that people with blood group B+ve, followed by O+ve had increased risk of developing OSCC with most prevalent being Well Differentiated OSCC as compared to people of other blood groups.The present study reveals that there is an inherited element in the susceptibility against different types of oral cancers. The people with blood group B+ve and O+ve having tobacco chewing habits can be appraised that they are more at risk to develop oral cancer than people with other blood groups.
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Ramesh G
      type: Person
      first name: Gayathri
      last name: Ramesh
      member of: Department of Oral and Maxillofacial Pathology, Rama Dental College Hospital and Research Centre, Kanpur, 208024, Uttar Pradesh, India.
  slot:
    index: 2
    item: Katiyar A
      type: Person
      first name: Anuradha
      last name: Katiyar
      member of: Department of Oral and Maxillofacial Pathology, Rama Dental College Hospital and Research Centre, Kanpur, 208024, Uttar Pradesh, India.
  slot:
    index: 3
    item: Raj A
      type: Person
      first name: Amrita
      last name: Raj
      member of: Department of Oral and Maxillofacial Pathology, Rama Dental College Hospital and Research Centre, Kanpur, 208024, Uttar Pradesh, India.
  slot:
    index: 4
    item: Kumar A
      type: Person
      first name: Amit
      last name: Kumar
      member of: Department of Oral and Maxillofacial Pathology, Rama Dental College Hospital and Research Centre, Kanpur, 208024, Uttar Pradesh, India.
  slot:
    index: 5
    item: Nagarajappa R
      type: Person
      first name: Ramesh
      last name: Nagarajappa
      member of: Dept. of Public Health Dentistry, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
  slot:
    index: 6
    item: Pandey A
      type: Person
      first name: Amit
      last name: Pandey
      member of: Department of Periodontics, Rama Dental College Hospital and Research Center, Kanpur, 208024, Uttar Pradesh, India.
created: 2017-11-22T06:00
date last updated: 2025-01-17
issued: 2017-11
dp: 2017 Nov
ISSN: 1359-4117
has issn l: 1359-4117
issue: 2
has NLM journal title abbreviation: J Exp Ther Oncol
publication name: Journal of experimental therapeutics & oncology
language: eng
has national library of medicine journal id: 9604933
derived from: NLM
starting page: 129
ending page: 135
has place of publication: United States
has primary subject term: D000017
has primary subject term: D009062Q000097Q000209Q000473
has subject term: D000293
has subject term: D000328
has subject term: D000368
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D060787
has subject term: D012727
has subject term: D055815
source: J Exp Ther Oncol. 2017-11;12(2):129-135.
volume: 12

Latin America makes progress on tobacco control.
pmid: 28462898
has PII: S2213-2600(17)30160-1
doi: 10.1016/S2213-2600(17)30160-1
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Burki TK
      type: Person
      first name: Talha Khan
      last name: Burki
created: 2017-5-4T06:00
date last updated: 2025-01-17
issued: 2017-06
dp: 2017 06
created: 2017-5-3T06:00
e ISSN: 2213-2619
has issn l: 2213-2600
issue: 6
has NLM journal title abbreviation: Lancet Respir Med
publication name: The Lancet. Respiratory medicine
language: eng
has national library of medicine journal id: 101605555
derived from: NLM
pg: 470
has place of publication: England
has primary subject term: D019064Q000331
has primary subject term: D061845Q000331
has primary subject term: D013660Q000331
has primary subject term: D019460Q000331
has subject term: D006801
has subject term: D007843
has subject term: D000074606Q000331
has subject term: D014028Q000331Q000517
source: Lancet Respir Med. 2017-06;5(6):470.
volume: 5

Evidentiary Support in Public Comments to the FDA's Center for Tobacco Products.
pmid: 28483810
abstract: Electronic Nicotine Delivery Systems (ENDS) were introduced into the US market in 2007, and until recently these devices were unregulated at the federal level. In 2014, the US Food and Drug Administration (FDA) published a Notice of Proposed Rulemaking asserting its intention to regulate ENDS and requesting public comments on numerous related issues, including potential limits on the sale of flavored ENDS. This article analyzes key comments submitted to the FDA on the issue of flavor regulation in ENDS and examines the weight and credibility of the evidence presented by both supporters and opponents of regulation. It also describes the final deeming rule, published in May 2016, and the FDA's response to the evidence submitted. This is the first study to examine public comments submitted to the FDA's Center for Tobacco Products, and it concludes that opponents of regulation were more likely to rely on sources that were not peer reviewed and that were affected by conflicts of interest. In light of these findings, the FDA and the research community should develop processes to carefully and critically analyze public comments submitted to the FDA on issues of tobacco regulation.
rights: Copyright © 2017 by Duke University Press.
has PII: 03616878-3856121
doi: 10.1215/03616878-3856121
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Hemmerich N
      type: Person
      first name: Natalie
      last name: Hemmerich
      member of: Ohio State University.
  slot:
    index: 2
    item: Klein EG
      type: Person
      first name: Elizabeth G
      last name: Klein
      member of: Ohio State University.
  slot:
    index: 3
    item: Berman M
      type: Person
      first name: Micah
      last name: Berman
      member of: Ohio State University.
created: 2017-5-10T06:00
date last updated: 2025-01-17
issued: 2017-08
dp: 2017 08
e ISSN: 1527-1927
has issn l: 0361-6878
issue: 4
has NLM journal title abbreviation: J Health Polit Policy Law
publication name: Journal of health politics, policy and law
language: eng
has national library of medicine journal id: 7609331
derived from: NLM
starting page: 645
ending page: 666
has place of publication: United States
has primary subject term: D003132Q000331
has primary subject term: D003256
has primary subject term: D066300
has primary subject term: D011639
has primary subject term: D014486
has subject term: D005421
has subject term: D006801
has subject term: D014481
source: J Health Polit Policy Law. 2017-08;42(4):645-666.
volume: 42

Looming threat of Asian tobacco companies to global health.
pmid: 28534742
has PII: S0140-6736(17)31223-0
doi: 10.1016/S0140-6736(17)31223-0
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Lee K
      type: Person
      first name: Kelley
      last name: Lee
      member of: Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. Electronic address: kelley_lee@sfu.ca.
  slot:
    index: 2
    item: Eckhardt J
      type: Person
      first name: Jappe
      last name: Eckhardt
      member of: Department of Politics, University of York, York, UK.
created: 2017-5-24T06:00
date last updated: 2025-01-17
issued: 2017-05-20
dp: 2017 May 20
e ISSN: 1474-547X
has issn l: 0140-6736
issue: 10083
has NLM journal title abbreviation: Lancet
publication name: Lancet (London, England)
language: eng
has national library of medicine journal id: 2985213R
derived from: NLM
starting page: 1958
ending page: 1960
has place of publication: England
has primary subject term: D014943
has primary subject term: D019460Q000331
has subject term: D001208
has subject term: D006291
has subject term: D006801
has subject term: D038622
has subject term: D040541
has subject term: D011634
source: Lancet. 2017-05-20;389(10083):1958-1960.
volume: 389

Australian lobbyist registers are not serving the purposes they were designed for.
pmid: 28695571
abstract: There is widespread concern about the nature, extent and impacts of lobbying by industries selling unhealthy commodities, which threatens public health and undermines important democratic processes. In the last decade, all Australian jurisdictions (except the Northern Territory) have established lobbyist registers with the stated objective of increasing the capacity of government and the public to scrutinise lobbying. Our aim was to assess whether the registers are fulfilling this objective.We conducted web searches of registers in Australian jurisdictions in 2014 and 2015 to determine what type of information they collected and whether data were accessible. We supplemented searches with e-mails and phone calls to registrars to clarify policies and seek additional information.We found that the data were lacking in critical details and historical information was difficult or impossible to obtain. None of the registers required in-house lobbyists to register or to be bound by the Lobbying Codes of Conduct. None required that informal lobbying (e.g. by government relations staff within a company) be recorded, and none provided detailed information about the nature and extent of lobbying activities.The registers do not meet the stated objective of making lobbying activity transparent to the Australian public. Timely access to comprehensive information is essential to help promote the rational development of policy concerning tobacco, alcohol and gambling problems. There is an urgent need to reform lobbyist registers to ensure that they are comprehensive and transparent.
rights: © 2017 Australasian Professional Society on Alcohol and other Drugs.
doi: 10.1111/dar.12583
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Robertson N
      type: Person
      first name: Narelle
      last name: Robertson
      member of: School of Psychology Deakin University, Geelong, Australia.
  slot:
    index: 2
    item: Kypri K
      type: Person
      first name: Kypros
      last name: Kypri
      member of: School of Medicine and Public Health, Newcastle University, Newcastle, Australia.
  slot:
    index: 3
    item: Stafford J
      type: Person
      first name: Julia
      last name: Stafford
      member of: Faculty of Health Sciences, Curtin University, Perth, Australia.
  slot:
    index: 4
    item: Daube M
      type: Person
      first name: Mike
      last name: Daube
      member of: Faculty of Health Sciences, Curtin University, Perth, Australia.
  slot:
    index: 5
    item: Avery M
      type: Person
      first name: Michelle
      last name: Avery
      member of: School of Psychology Deakin University, Geelong, Australia.
  slot:
    index: 6
    item: Miller P
      type: Person
      first name: Peter
      last name: Miller
      member of: School of Psychology Deakin University, Geelong, Australia.
created: 2017-7-12T06:00
date last updated: 2025-01-17
issued: 2018-04
dp: 2018 04
e ISSN: 1465-3362
has issn l: 0959-5236
has NLM journal title abbreviation: Drug Alcohol Rev
publication name: Drug and alcohol review
language: eng
has national library of medicine journal id: 9015440
derived from: NLM
starting page: S218
ending page: S222
has place of publication: Australia
has primary subject term: D000434
has primary subject term: D008119
has primary subject term: D011057
has primary subject term: D011640
has subject term: D001315
has subject term: D006801
has subject term: D012042
has subject term: D019460
source: Drug Alcohol Rev. 2018-04;37 Suppl 1():S218-S222.
volume: 37 Suppl 1

Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.
pmid: 29207086
abstract: Tanshinone IIA (Tan IIA), as a bioactive compound extracted from the dried roots of Salvia miltiorrhiza (also known as Danshen), is known to inhibit cancer cell proliferation and induce apoptosis. However, the mechanisms underlying the function of Tan IIA in cancer cell apoptosis remain to be elucidated The aim of the present study was to identify the molecular mechanisms underlying the anti‑cancer effects of Tan IIA in p53‑deficient H1299 cells. Tan IIA was demonstrated to suppress murine double minute 4 (MDM4) expression in a time‑ and dose‑dependent manner through the inhibition of MDM4 mRNA synthesis. Tan IIA‑induced downregulation of MDM4 resulted in an increase of P73α and a decrease of inhibitor of apoptosis 3 (IAP3). However, P73α was not activated as two P73α target genes, BCL2 binding component 3 and phorbol‑12‑myristate‑13‑acetate‑induced protein 1, were not significantly induced. Tan IIA‑induced inhibition of IAP3 expression may be involved in Tan IIA‑induced apoptosis and inhibition of H1299 cell viability. Notably, a combination of Tan IIA and doxorubicin (DOX) exposure resulted in further MDM4 overexpression in H1299 cells, indicating that Tan IIA sensitized p53‑deficient and MDM4‑overexpressing H1299 cells to DOX‑induced apoptosis.
doi: 10.3892/mmr.2017.8152
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zu Y
      type: Person
      first name: Yukun
      last name: Zu
      member of: Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
  slot:
    index: 2
    item: Wang J
      type: Person
      first name: Jianning
      last name: Wang
      member of: Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
  slot:
    index: 3
    item: Ping W
      type: Person
      first name: Wei
      last name: Ping
      member of: Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
  slot:
    index: 4
    item: Sun W
      type: Person
      first name: Wei
      last name: Sun
      member of: Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
created: 2017-12-6T06:00
date last updated: 2025-01-17
issued: 2018-02
dp: 2018 Feb
e ISSN: 1791-3004
has issn l: 1791-2997
issue: 2
has NLM journal title abbreviation: Mol Med Rep
publication name: Molecular medicine reports
language: eng
has national library of medicine journal id: 101475259
derived from: NLM
starting page: 2384
ending page: 2392
has place of publication: Greece
has primary subject term: D045784Q000494
has primary subject term: D000972Q000494
has primary subject term: D051034Q000378
has primary subject term: D009687Q000235Q000378
has primary subject term: D011518Q000235Q000378
has primary subject term: D015398Q000187
has subject term: D017209Q000187
has subject term: D018797
has subject term: D045744
has subject term: D002470Q000187
has subject term: D015870
has subject term: D055785
has subject term: D006801
has subject term: D012333Q000235Q000378
source: Mol Med Rep. 2018-02;17(2):2384-2392.
volume: 17

[Claude Bernard and nicotinic receptors: from the neuromuscular junction to tobacco weaning].
pmid: 29236668
abstract: Claude Bernard (1813-1878) was fascinated by the pharmacological mechanisms of poisons. In particular, using a huge amount of ingenious and robust experiments, he demonstrated the peripheral toxic action of the natural compound curare. His work generated controversies in a period where scientific methodology and technical development followed the progression of concepts and ideas. From his intense debates with Albert Vulpian emerged the location of curare's toxicity at the neuromuscular junction. These two fascinating scientists could not imagine how important were these discoveries which allowed John Langley to propose the concept of receptor early in the 20th century. At the same time, the German immunologist Paul Ehrlich suggested that these receptors could be targeted by so-called magic bullets , i.e., drugs that act on receptors, in order to treat patients. The molecular substrate of curare's activity was identified many years later as the nicotinic receptor of the motor end-plate. We now have curare molecules belonging to various chemical families that block receptors during anaesthesia. Suggamadex is the antidote for two of them, a drug that Claude Bernard perhaps dreamt of. We also have the recently marketed varenicline that acts as a partial agonist of nicotinic receptors in the central nervous system to treat patients from tobacco addiction. This rich story shows that biomedical research needs collaborations, imagination, perspicacity but also all results that it can have many years later, therefore challenging researchers about consequences of their discoveries.
rights: © Société de Biologie, 2017.
has PII: jbio170024
doi: 10.1051/jbio/2017024
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Monassier L
      type: Person
      first name: Laurent
      last name: Monassier
      member of: Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Fédération de Médecine Translationnelle, Université et CHU de Strasbourg, 11 rue Humann, 67085 Strasbourg, France.
created: 2017-12-14T06:00
date last updated: 2025-01-17
issued: 2017
dp: 2017
e ISSN: 2105-0686
has issn l: 2105-0678
issue: 2
has NLM journal title abbreviation: Biol Aujourdhui
publication name: Biologie aujourd'hui
language: fre
has national library of medicine journal id: 101544020
derived from: NLM
starting page: 169
ending page: 172
has place of publication: France
has primary subject term: D035843Q000266
has primary subject term: D059232Q000266
has primary subject term: D009469Q000502
has primary subject term: D011978Q000502
has primary subject term: D016540Q000379
has subject term: D003472
has subject term: D049672
has subject term: D049673
has subject term: D006801
has subject term: D014029Q000503Q000628
source: Biol Aujourdhui. 2017;211(2):169-172.
volume: 211

Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study.
pmid: 29236289
abstract: The intriguing molecular pathways involved in oral carcinogenesis are still ambiguous. The oral squamous cell carcinoma (OSCC) ranks as the most common type constituting more than 90% of the globally diagnosed oral cancers cases. The elevation in the OSCC incidence rate during past 10 years has an alarming impression on human healthcare. The major challenges associated with OSCC include delayed diagnosis, high metastatic rates, and low 5-year survival rates. The present work foundations on reverse genetic strategy and involves the identification of genes showing expressional variability in an OSCC case lacking addictive proclivities for tobacco, betel nut, and/or alcohol, major etiologies. The expression modulations in the identified genes were analyzed in 16 patients comprising oral pre-cancer and cancer histo-pathologies. The genes SCCA1 and KRT1 were found to down regulate while DNAJC13, GIPC2, MRPL17, IG-Vreg, SSFA2, and UPF0415 upregulated in the oral pre-cancer and cancer pathologies, implicating the genes as crucial players in oral carcinogenesis.
rights: © 2017 Wiley Periodicals, Inc.
doi: 10.1002/jcb.26554
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Khowal S
      type: Person
      first name: Sapna
      last name: Khowal
      member of: Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
  slot:
    index: 2
    item: Naqvi SH
      type: Person
      first name: Samar H
      last name: Naqvi
      member of: Molecular Diagnostics, Genetix Biotech Asia (P) Ltd., New Delhi, India.
  slot:
    index: 3
    item: Monga S
      type: Person
      first name: Seema
      last name: Monga
      member of: Department of ENT, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
  slot:
    index: 4
    item: Jain SK
      type: Person
      first name: Swatantra K
      last name: Jain
      member of: Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
  slot:
    index: 5
    item: Wajid S
      type: Person
      first name: Saima
      last name: Wajid
      member of: Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
created: 2017-12-14T06:00
date last updated: 2025-01-17
issued: 2018-07
dp: 2018 07
e ISSN: 1097-4644
has issn l: 0730-2312
issue: 7
has NLM journal title abbreviation: J Cell Biochem
publication name: Journal of cellular biochemistry
language: eng
has national library of medicine journal id: 8205768
derived from: NLM
starting page: 5186
ending page: 5221
has place of publication: United States
has primary subject term: D001114Q000009
has primary subject term: D002294Q000378Q000821
has primary subject term: D000431Q000009
has primary subject term: D009062Q000378
has primary subject term: D020543Q000378
has primary subject term: D014062Q000378Q000821
has subject term: D000368
has subject term: D015180
has subject term: D005260
has subject term: D052162Q000472
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D060888
has subject term: D019032
has subject term: D000077195Q000378Q000821
source: J Cell Biochem. 2018-07;119(7):5186-5221.
volume: 119

Preclinical Evidence for Combined Use of Aromatase Inhibitors and NSAIDs as Preventive Agents of Tobacco-Induced Lung Cancer.
pmid: 29233790
abstract: A hormonal role in NSCLC development is well documented. We previously showed that the aromatase inhibitor (AI) anastrozole decreased development of tobacco carcinogen-induced lung tumors in a murine lung cancer prevention model and that aromatase and estrogen receptor were expressed in pulmonary inflammatory cells.We utilized a tobacco carcinogen-induced lung tumor mouse model by treatment with 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK), to determine whether an AI combined with nonsteroidal anti-inflammatory drugs results in greater lung tumor prevention effects compared to single-agent treatment.Combination of anastrozole (0.1 mg/kg/d) with aspirin (25 mg/kg/d) after NNK exposure resulted in significantly fewer and smaller lung tumors than did single-agent treatments and was accompanied by maximum decreases in circulating β-estradiol (E2) and interleukin-6, tumor-infiltrating macrophages, and tumoral Ki67, phospho-mitogen-activated protein kinase, phospho-signal transducer and activator of transcription 3, and interleukin-17A expression. Preneoplasia arising after combination treatment showed the lowest Sox-2 expression, suggesting an inhibitory effect on proliferative capacity in the airways by blocking both E2 and inflammation. Anastrozole combined with ibuprofen instead of aspirin also showed enhanced antitumor effects. Moreover, male mice treated with NNK that received E2 in their drinking water showed greater levels of pulmonary macrophages and inflammatory markers than did the control, confirming an E2 effect on inflammation in the microenvironment.Our results suggest a benefit to joint targeting of the estrogen and inflammatory pathways for NSCLC prevention. Combining AIs with nonsteroidal anti-inflammatory drugs reduces circulating E2, proinflammatory cytokines, and macrophage recruitment in the lung microenvironment after tobacco exposure. This strategy could be particularly effective in women who have underlying pulmonary inflammatory diseases[cell cut: 2001 characters, first 2000 kept]
rights: Copyright © 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
has PII: S1556-0864(17)33076-9
doi: 10.1016/j.jtho.2017.11.126
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Stabile LP
      type: Person
      first name: Laura P
      last name: Stabile
      member of: Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania. Electronic address: stabilela@upmc.edu.
  slot:
    index: 2
    item: Farooqui M
      type: Person
      first name: Mariya
      last name: Farooqui
      member of: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.
  slot:
    index: 3
    item: Kanterewicz B
      type: Person
      first name: Beatriz
      last name: Kanterewicz
      member of: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
  slot:
    index: 4
    item: Abberbock S
      type: Person
      first name: Shira
      last name: Abberbock
      member of: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
  slot:
    index: 5
    item: Kurland BF
      type: Person
      first name: Brenda F
      last name: Kurland
      member of: Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania.
  slot:
    index: 6
    item: Diergaarde B
      type: Person
      first name: Brenda
      last name: Diergaarde
      member of: UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
  slot:
    index: 7
    item: Siegfried JM
      type: Person
      first name: Jill M
      last name: Siegfried
      member of: Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.
created: 2017-12-14T06:00
date last updated: 2025-01-17
issued: 2018-03
dp: 2018 03
e ISSN: 1556-1380
has issn l: 1556-0864
issue: 3
has NLM journal title abbreviation: J Thorac Oncol
publication name: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
language: eng
has national library of medicine journal id: 101274235
derived from: NLM
starting page: 399
ending page: 412
has place of publication: United States
has primary subject term: D000894Q000494Q000627
has primary subject term: D047072Q000494Q000627
has primary subject term: D008175Q000188Q000473
has subject term: D000818
has subject term: D002273
has subject term: D004195
has subject term: D005260
has subject term: D006801
has subject term: D051379
source: J Thorac Oncol. 2018-03;13(3):399-412.
volume: 13

http://rdf.ncbi.nlm.nih.gov/pubmed/29390940
pmid: 29390940
abstract: Lung cancer is the most common cause of cancer-related deaths in humans worldwide. There is strong evidence that the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) play an important role in carcinogenesis caused by tobacco products. NNK and racemic NNAL are reported to induce lung and pancreatic tumors in rats. The carcinogenicity in Fischer 344 rats of NNK, NNAL, and its enantiomers ( R)-NNAL and ( S)-NNAL has been studied recently, and all test compounds induced significant numbers of lung tumors. We report here the detailed histopathological and immunohistochemical characterization of these tumors and their aggressive nature as shown by their metastasis locally and to the pancreas. The spectrum of treatment-related histopathological findings comprised pulmonary alveolar/bronchiolar (A/B) epithelial hyperplasia, A/B adenomas, and A/B carcinomas. A/B carcinomas frequently exhibited local invasion/metastasis within the mediastinum and thoracic cavity and distant metastasis to the pancreas that was confirmed by immunohistochemistry using the lung-specific markers prosurfactant protein-C and club (Clara) cell-10. Our observation regarding metastasis to the pancreas was an important, and unexpected, finding in this study both for the experimental animal model and potential human relevance.
doi: 10.1177/0192623317751573
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kovi RC
      type: Person
      first name: Ramesh C
      last name: Kovi
      member of: 1 Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA.2 Masonic Cancer Center, University of Minnesota, St. Paul, Minnesota, USA.3 Experimental Pathology Laboratories, Inc. (EPL Inc.)/Cellular and Molecular Pathology Branch, NIEHS, Research Triangle Park, North Carolina, USA.
  slot:
    index: 2
    item: Johnson CS
      type: Person
      first name: Charles S
      last name: Johnson
      member of: 1 Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA.2 Masonic Cancer Center, University of Minnesota, St. Paul, Minnesota, USA.
  slot:
    index: 3
    item: Balbo S
      type: Person
      first name: Silvia
      last name: Balbo
      member of: 2 Masonic Cancer Center, University of Minnesota, St. Paul, Minnesota, USA.
  slot:
    index: 4
    item: Hecht SS
      type: Person
      first name: Stephen S
      last name: Hecht
      member of: 2 Masonic Cancer Center, University of Minnesota, St. Paul, Minnesota, USA.
  slot:
    index: 5
    item: O'Sullivan MG
      type: Person
      first name: M Gerard
      last name: O'Sullivan
      member of: 1 Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA.2 Masonic Cancer Center, University of Minnesota, St. Paul, Minnesota, USA.
created: 2018-2-3T06:00
date last updated: 2025-01-17
issued: 2018-02
dp: 2018 02
e ISSN: 1533-1601
has issn l: 0192-6233
issue: 2
has NLM journal title abbreviation: Toxicol Pathol
publication name: Toxicologic pathology
language: eng
has national library of medicine journal id: 7905907
derived from: NLM
starting page: 184
ending page: 192
has place of publication: United States
has primary subject term: D002273Q000378Q000633
has primary subject term: D008175Q000139Q000473
has primary subject term: D009602Q000378Q000633
has primary subject term: D010190Q000556
has subject term: D000818
has subject term: D008297
has subject term: D051381
has subject term: D002277Q000139Q000556
has subject term: D011916
has subject term: D013237
has subject term: D062789Q000009
source: Toxicol Pathol. 2018-02;46(2):184-192.
title: Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products.
volume: 46

The geography of crime and violence surrounding tobacco shops, medical marijuana dispensaries, and off-sale alcohol outlets in a large, urban low-income community of color.
pmid: 29277409
abstract: Tobacco shops, medical marijuana dispensaries (MMD), and off-sale alcohol outlets are legal and prevalent in South Los Angeles, California-a high-crime, low-income urban community of color. This research is the first to explore the geographic associations between these three legal drug outlets with surrounding crime and violence in a large low-income urban community of color. First, spatial buffer analyses were performed using point-location and publically accessible January-December 2014 crime data to examine the geography of all felony property and violent crimes occurring within 100, 200, 500, and 1000-foot buffers of these three legal drug outlet types across South Los Angeles. Next, spatial regression analyses explored the geographic associations between density of these outlets and property and violent crimes at the census tract level. Results indicated that mean property and violent crime rates within 100-foot buffers of tobacco shops and alcohol outlets-but not MMDs-substantially exceeded community-wide mean crime rates and rates around grocery/convenience stores (i.e., comparison properties licensed to sell both alcohol and tobacco). Spatial regression analyses confirmed that tobacco shops significantly positively associated with property and violent crimes after controlling for key neighborhood factors (poverty, renters, resident mobility, ethnic/racial heterogeneity). Thus, study findings provide the first empirical evidence that tobacco shops may constitute public health threats that associate with crime and violence in U.S. low-income urban communities of color. Implementing and enforcing control policies that regulate and monitor tobacco shops in these communities may promote community health by improving public safety.
rights: Copyright © 2017 Elsevier Inc. All rights reserved.
has PII: S0091-7435(17)30507-8
doi: 10.1016/j.ypmed.2017.12.020
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Subica AM
      type: Person
      first name: Andrew M
      last name: Subica
      member of: University of California Riverside, School of Medicine, Riverside, CA, United States. Electronic address: asubica@medsch.ucr.edu.
  slot:
    index: 2
    item: Douglas JA
      type: Person
      first name: Jason A
      last name: Douglas
      member of: San Jose State University, Environmental Studies, San Jose, CA, United States.
  slot:
    index: 3
    item: Kepple NJ
      type: Person
      first name: Nancy J
      last name: Kepple
      member of: University of Kansas, School of Social Welfare, Lawrence, KS, United States.
  slot:
    index: 4
    item: Villanueva S
      type: Person
      first name: Sandra
      last name: Villanueva
      member of: Loyola Marymount University, Psychology Applied Research Center, Los Angeles, CA, United States.
  slot:
    index: 5
    item: Grills CT
      type: Person
      first name: Cheryl T
      last name: Grills
      member of: Loyola Marymount University, Psychology Applied Research Center, Los Angeles, CA, United States.
created: 2017-12-27T06:00
date last updated: 2025-01-17
issued: 2018-03
dp: 2018 03
e ISSN: 1096-0260
has issn l: 0091-7435
has NLM journal title abbreviation: Prev Med
publication name: Preventive medicine
language: eng
has national library of medicine journal id: 0322116
derived from: NLM
starting page: 8
ending page: 16
has place of publication: United States
has primary subject term: D000428Q000639
has primary subject term: D003132Q000706
has primary subject term: D003415Q000706
has primary subject term: D005006
has primary subject term: D005843Q000706
has primary subject term: D064086Q000600
has primary subject term: D062206
has primary subject term: D014754Q000706
has subject term: D006801
has subject term: D015141
has subject term: D011203
source: Prev Med. 2018-03;108():8-16.
volume: 108

Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice.
pmid: 29421645
abstract: Although epidemiological data and results from rodent studies support an inverse relationship between nicotine consumption and body weight, the molecular mechanisms are poorly understood. CD-1 mice were fed a basal diet or a basal diet containing low or high dose smokeless tobacco blend or high dose nicotine tartrate for 14 weeks. High dose tobacco blend and nicotine tartrate diets vs. basal diet reduced mouse body weight (16.3% and 19.7%, respectively), epididymal (67.6% and 72.5%, respectively) and brown adipose weight (42% and 38%, respectively), epididymal adipocyte size (46.4% and 41.4%, respectively), and brown adipose tissue lipid droplet abundance, with no elevation of adipose tissue inflammation. High dose tobacco blend and nicotine diets also increased mouse physical activity and decreased respiratory exchange ratio, suggesting that high dose nicotine intake induces adipose tissue triglyceride lipolysis to provide fatty acids as an energy source. Both low and high dose tobacco blend and nicotine diet feeding vs. basal diet increased plasma insulin levels (2.9, 3.6 and 4.3-fold, respectively) and improved blood glucose disposal without affecting insulin sensitivity. Feeding of the high dose tobacco blend or nicotine feeding in mice induces body weight loss likely by increasing physical activity and stimulating adipose tissue triglyceride lipolysis.
rights: Copyright © 2018. Published by Elsevier Ltd.
has PII: S0278-6915(18)30064-4
doi: 10.1016/j.fct.2018.01.058
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Liu M
      type: Person
      first name: Mingxia
      last name: Liu
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA. Electronic address: mliu@wakehealth.edu.
  slot:
    index: 2
    item: Chuang Key CC
      type: Person
      first name: Chia-Chi
      last name: Chuang Key
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA.
  slot:
    index: 3
    item: Weckerle A
      type: Person
      first name: Allison
      last name: Weckerle
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA.
  slot:
    index: 4
    item: Boudyguina E
      type: Person
      first name: Elena
      last name: Boudyguina
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA.
  slot:
    index: 5
    item: Sawyer JK
      type: Person
      first name: Janet K
      last name: Sawyer
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA.
  slot:
    index: 6
    item: Gebre AK
      type: Person
      first name: Abraham K
      last name: Gebre
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA.
  slot:
    index: 7
    item: Spoo W
      type: Person
      first name: Wayne
      last name: Spoo
      member of: RAI Services Company, Scientific and Regulatory Affairs, Winston-Salem, NC 27101, USA.
  slot:
    index: 8
    item: Makwana O
      type: Person
      first name: Om
      last name: Makwana
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA; RAI Services Company, Scientific and Regulatory Affairs, Winston-Salem, NC 27101, USA.
  slot:
    index: 9
    item: Parks JS
      type: Person
      first name: John S
      last name: Parks
      member of: Departments of Internal Medicine, Section on Molecular Medicine, Winston-Salem, NC 27157, USA; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: jparks@wakehealth.edu.
created: 2018-2-9T06:00
date last updated: 2025-01-17
issued: 2018-03
dp: 2018 Mar
e ISSN: 1873-6351
has issn l: 0278-6915
has NLM journal title abbreviation: Food Chem Toxicol
publication name: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
language: eng
has national library of medicine journal id: 8207483
derived from: NLM
starting page: 287
ending page: 295
has place of publication: England
has primary subject term: D017667Q000166Q000187
has primary subject term: D009538Q000494
has primary subject term: D010805
has primary subject term: D015431Q000187
has subject term: D000273Q000378
has subject term: D000818
has subject term: D001786Q000378
has subject term: D048429
has subject term: D005247
has subject term: D007328Q000097
has subject term: D007333
has subject term: D008066
has subject term: D008297
has subject term: D051379
has subject term: D014280Q000378
source: Food Chem Toxicol. 2018-03;113():287-295.
volume: 113

Adopting New International Health Instruments - What Can We Learn From the FCTC? Comment on The Legal Strength of International Health Instruments - What It Brings to Global Health Governance?
pmid: 29524955
abstract: This Commentary forms a response to Nikogosian's and Kickbusch's forward-looking perspective about the legal strength of international health instruments. Building on their arguments, in this commentary we consider what we can learn from the Framework Convention on Tobacco Control (FCTC) for the adoption of new legal international health instruments.
rights: © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
doi: 10.15171/ijhpm.2017.78
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Hesselman M
      type: Person
      first name: Marlies
      last name: Hesselman
      member of: Department of International Law/Global Health Law Groningen, Faculty of Law, University of Groningen, Groningen, The Netherlands.
  slot:
    index: 2
    item: Toebes B
      type: Person
      first name: Brigit
      last name: Toebes
      member of: Global Health Law Groningen Research Centre, Faculty of Law, University of Groningen, Groningen, The Netherlands.
created: 2018-3-12T06:00
date last updated: 2025-01-17
issued: 2018-03-01
dp: 2018 03 01
e ISSN: 2322-5939
has issn l: 2322-5939
issue: 3
has NLM journal title abbreviation: Int J Health Policy Manag
publication name: International journal of health policy and management
language: eng
has national library of medicine journal id: 101619905
derived from: NLM
starting page: 264
ending page: 267
has place of publication: Iran
has primary subject term: D014943
has subject term: D006291
has subject term: D006801
has subject term: D007391
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D019460Q000331
has subject term: D014944
source: Int J Health Policy Manag. 2018-03-01;7(3):264-267.
volume: 7

Tobacco influence in heavy metals levels in head and neck cancer cases.
pmid: 30056540
abstract: Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper.
has PII: 10.1007/s11356-018-2668-9
doi: 10.1007/s11356-018-2668-9
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Bandeira CM
      type: Person
      first name: Celso Muller
      last name: Bandeira
      member of: Department of Biosciences and Oral Diagnosis, Sao Paulo State University (Unesp), Institute of Science and Technology, Av. Eng. Francisco José Longo 777, Sao Jose dos Campos, SP, Brazil.
  slot:
    index: 2
    item: de Almeida AÁ
      type: Person
      first name: Adriana Ávila
      last name: de Almeida
      member of: Department of Biosciences and Oral Diagnosis, Sao Paulo State University (Unesp), Institute of Science and Technology, Av. Eng. Francisco José Longo 777, Sao Jose dos Campos, SP, Brazil.
  slot:
    index: 3
    item: Carta CFL
      type: Person
      first name: Celina Faig Lima
      last name: Carta
      member of: Mogi das Cruzes, University Braz Cubas, Sao Paulo, Brazil.
  slot:
    index: 4
    item: Almeida AA
      type: Person
      first name: Alaor Aparecido
      last name: Almeida
      member of: Center of Toxicological Assistance (CEATOX), Sao Paulo State University (Unesp), Institute of Biosciences of Botucatu, Botucatu, SP, Brazil.
  slot:
    index: 5
    item: de Figueiredo FAT
      type: Person
      first name: Fellipe Augusto Tocchini
      last name: de Figueiredo
      member of: Department of Biosciences and Oral Diagnosis, Sao Paulo State University (Unesp), Institute of Science and Technology, Av. Eng. Francisco José Longo 777, Sao Jose dos Campos, SP, Brazil.
  slot:
    index: 6
    item: Sandrim VC
      type: Person
      first name: Valeria Cristina
      last name: Sandrim
      member of: Department of Pharmacology, Sao Paulo State University (Unesp), Institute of Biosciences of Botucatu, Botucatu, SP, Brazil.
  slot:
    index: 7
    item: Gonçalves AJ
      type: Person
      first name: Antonio José
      last name: Gonçalves
      member of: Department of Head and Neck Surgery, Medical Sciences College, Irmandade daSanta Casa de Misericordia de Sao Paulo (ISCMSP), Sao Paulo, SP, Brazil.
  slot:
    index: 8
    item: Almeida JD
      type: Person
      first name: Janete Dias
      last name: Almeida
      member of: Department of Biosciences and Oral Diagnosis, Sao Paulo State University (Unesp), Institute of Science and Technology, Av. Eng. Francisco José Longo 777, Sao Jose dos Campos, SP, Brazil. janete@ict.unesp.br.
created: 2018-7-30T06:00
date last updated: 2025-01-17
issued: 2018-09
dp: 2018 Sep
e ISSN: 1614-7499
has issn l: 0944-1344
issue: 27
has NLM journal title abbreviation: Environ Sci Pollut Res Int
publication name: Environmental science and pollution research international
language: eng
has national library of medicine journal id: 9441769
derived from: NLM
starting page: 27650
ending page: 27656
has place of publication: Germany
has primary subject term: D002294Q000097Q000473
has primary subject term: D006258Q000097Q000473
has primary subject term: D019216Q000032Q000097
has primary subject term: D012907Q000097
has subject term: D000328
has subject term: D000368
has subject term: D016022
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D009367
has subject term: D011795
source: Environ Sci Pollut Res Int. 2018-09;25(27):27650-27656.
volume: 25

Single Nucleotide Polymorphisms in HMGB1 Correlate with Lung Cancer Risk in the Northeast Chinese Han Population.
pmid: 29617336
abstract: Lung cancer is the principal cause of cancer-associated deaths. HMGB1 has been reported to be associated with tumorigenesis. This study aimed to investigate the relationship between rs1412125 and rs1360485 polymorphisms in HMGB1 and the risk and survival of lung cancer. 850 cases and 733 controls were included. Logistic regression analysis and survival analysis were performed to investigate the association between SNPs and the risk and survival of lung cancer. Crossover analysis was used to analyze the interaction between SNPs and tobacco exposure. Results indicated that rs1412125 polymorphism was associated with lung cancer risk, especially with the risk of lung adenocarcinoma and small cell lung cancer. Carriers with CT and CC genotypes had a decreased risk of lung cancer (CT + CC vs.TT: adjusted OR = 0.736, p = 0.004). Similar results were obtained in the stratification analysis for non-smokers and female population. For rs1360485 polymorphism, AG and GG genotypes could decrease the risk of lung adenocarcinoma and female lung cancer by 0.771-fold and 0.789-fold. However, no significant interaction between polymorphisms and tobacco exposure or association between SNPs and the survival of lung cancer was observed. This study indicated polymorphisms in HMGB1 may be a novel biomarker for female lung adenocarcinoma risk.
has PII: molecules23040832
doi: 10.3390/molecules23040832
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Jiang M
      type: Person
      first name: Min
      last name: Jiang
      member of: Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. mij9620@163.com.Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Province Department of Education, Shenyang 110122, China. mij9620@163.com.
  slot:
    index: 2
    item: Li X
      type: Person
      first name: Xuelian
      last name: Li
      member of: Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. xlli@mail.cmu.edu.cn.Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Province Department of Education, Shenyang 110122, China. xlli@mail.cmu.edu.cn.
  slot:
    index: 3
    item: Quan X
      type: Person
      first name: Xiaowei
      last name: Quan
      member of: Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. quanxiaowei126@126.com.Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Province Department of Education, Shenyang 110122, China. quanxiaowei126@126.com.
  slot:
    index: 4
    item: Li X
      type: Person
      first name: Xiaoying
      last name: Li
      member of: Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. xyingl0608@163.com.Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Province Department of Education, Shenyang 110122, China. xyingl0608@163.com.
  slot:
    index: 5
    item: Zhou B
      type: Person
      first name: Baosen
      last name: Zhou
      member of: Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China. bszhou@cmu.edu.cn.Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Province Department of Education, Shenyang 110122, China. bszhou@cmu.edu.cn.
created: 2018-4-5T06:00
date last updated: 2025-01-17
issued: 2018-04-04
dp: 2018 Apr 04
e ISSN: 1420-3049
has issn l: 1420-3049
issue: 4
has NLM journal title abbreviation: Molecules
publication name: Molecules (Basel, Switzerland)
language: eng
has national library of medicine journal id: 100964009
derived from: NLM
has place of publication: Switzerland
has primary subject term: D024243Q000235
has primary subject term: D008175Q000201Q000453Q000235Q000378
has primary subject term: D020641Q000235
has subject term: D000230Q000201Q000235Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000077192
has subject term: D044466
has subject term: D005260
has subject term: D005838
has subject term: D006801
has subject term: D008297
has subject term: D055752Q000201Q000235Q000378
source: Molecules. 2018-04-04;23(4):.
volume: 23

[Preadolescents' refusal skills and responses emotional reactions to the offer of tobacco and ecstasy in Youjiang District in Baise City in 2014].
pmid: 29903228
abstract: To assess preadolescents' emotional reactions and intended use of refusal responses to tobacco and ecstasy.A total of 333 students from two junior schools in Baise City were recruited with cluster-sampling method, filled the questionnaire to assess a respondent's emotional reactions and refusal skills in response to an offer of tobacco and MDMA from Feb to Jul 2014.88. 89%-93. 39% of preadolescents would more likely to use say no and tell them you don't want it . A series of 2( type of drug) × 2( offerer) × 2( sex) ANOVAs showed there were main effects for sex in explicit refusal scale ( F = 8. 391, P = 0. 004), excuse scale ( F =156. 560, P < 0. 001), implicit refusal scale ( F = 84. 498, P < 0. 001), aggression scale ( F = 31. 911, P < 0. 001). For the excuse scale, there were main effects for drug( F = 12. 009, P = 0. 001). A series of χ~2-tests showed that participants were more curious to MDMA offers than tobacco offers from close friends and acquaintances( χ~2=13. 76, P = 0. 0003; χ~2= 10. 24, P = 0. 002). For the close friends offers, participants were more pleasure to tobacco offers than MDMA offers( χ~2= 8. 33, P = 0. 006).There were significant effects of sex and offers in refusal style for drug offers. Preadolescents would show different emotional reaction to type of drug supplier or provider.
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Guo R
      type: Person
      first name: Rui
      last name: Guo
      member of: School of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China.
  slot:
    index: 2
    item: Liao J
      type: Person
      first name: Jianying
      last name: Liao
      member of: School of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China.
  slot:
    index: 3
    item: Liang J
      type: Person
      first name: Jiancheng
      last name: Liang
      member of: School of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China.
  slot:
    index: 4
    item: Li Y
      type: Person
      first name: Yang
      last name: Li
      member of: School of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China.
  slot:
    index: 5
    item: Deng S
      type: Person
      first name: Shusong
      last name: Deng
      member of: School of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China.
created: 2018-6-16T06:00
date last updated: 2025-01-17
issued: 2018-01
dp: 2018 Jan
ISSN: 1000-8020
has issn l: 1000-8020
issue: 1
has NLM journal title abbreviation: Wei Sheng Yan Jiu
publication name: Wei sheng yan jiu = Journal of hygiene research
language: chi
has national library of medicine journal id: 9426367
derived from: NLM
starting page: 80
ending page: 92
has place of publication: China
has primary subject term: D000339
has primary subject term: D004644
has primary subject term: D018817
has primary subject term: D010379
has primary subject term: D013334Q000523
has subject term: D002648
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D012574
has subject term: D012919
has subject term: D011795
source: Wei Sheng Yan Jiu. 2018-01;47(1):80-92.
volume: 47

Including a Novel Tobacco Product in Oregon's Indoor Clean Air Act: Lessons Learned for Clean Air Policy, 2015-2016.
pmid: 29614237
doi: 10.1177/0033354918765439
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Fiala SC
      type: Person
      first name: Steven C
      last name: Fiala
      member of: 1 Program Design and Evaluation Services, Oregon Public Health Division, Oregon Health Authority, Portland, OR, USA.
  slot:
    index: 2
    item: Drach LL
      type: Person
      first name: Linda L
      last name: Drach
      member of: 1 Program Design and Evaluation Services, Oregon Public Health Division, Oregon Health Authority, Portland, OR, USA.
  slot:
    index: 3
    item: Parkman SW
      type: Person
      first name: Shaun W
      last name: Parkman
      member of: 2 Health Promotion and Chronic Disease Prevention Section, Oregon Public Health Division, Oregon Health Authority, Portland, OR, USA.
  slot:
    index: 4
    item: Hargand SL
      type: Person
      first name: Sarah L
      last name: Hargand
      member of: 2 Health Promotion and Chronic Disease Prevention Section, Oregon Public Health Division, Oregon Health Authority, Portland, OR, USA.
  slot:
    index: 5
    item: Girard KE
      type: Person
      first name: Karen E
      last name: Girard
      member of: 2 Health Promotion and Chronic Disease Prevention Section, Oregon Public Health Division, Oregon Health Authority, Portland, OR, USA.
created: 2018-4-4T06:00
date last updated: 2025-01-17
e ISSN: 1468-2877
has issn l: 0033-3549
issue: 3
has NLM journal title abbreviation: Public Health Rep
publication name: Public health reports (Washington, D.C. : 1974)
language: eng
has national library of medicine journal id: 9716844
derived from: NLM
starting page: 230
ending page: 233
has place of publication: United States
has primary subject term: D016902Q000331
has primary subject term: D011050
has primary subject term: D061845Q000331
has primary subject term: D014028Q000009Q000331
has subject term: D066300Q000295Q000379
has subject term: D006291
has subject term: D006801
source: Public Health Rep. ;133(3):230-233.
volume: 133

Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry.
pmid: 29688089
abstract: To measure the area of central scotoma obtained with semi-automated kinetic perimetry (SKP) in patients suffering from tobacco-alcohol toxic neuropathy (TATN).Twelve eyes of six patients with TATN were examined with SKP. Area of central scotoma was measured in square degrees (deg2). Additionally, static automated perimetry (SAP) within 60° was performed in each patient.Area of central scotoma was 41.8 deg2 for III4e isopter, 22.9 deg2 for I4e isopter and 16.1 deg2 for I2e isopter in TATN patients. SAP revealed central scotoma in all patients. There was 100% of accordance between two methods.SKP is comparable with SAP in assessing central scotoma. SKP offers advantage of measuring central scotoma and assessing remaining peripheral visual field in TATN, even with low incidence and prevalence of this clinical entity.
doi: 10.1080/15569527.2018.1459666
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Nowomiejska K
      type: Person
      first name: Katarzyna
      last name: Nowomiejska
      member of: a Department of General Ophthalmology , Medical University , Lublin , Poland.
  slot:
    index: 2
    item: Kiszka A
      type: Person
      first name: Agnieszka
      last name: Kiszka
      member of: a Department of General Ophthalmology , Medical University , Lublin , Poland.
  slot:
    index: 3
    item: Maciejewski R
      type: Person
      first name: Ryszard
      last name: Maciejewski
      member of: b Human Anatomy Department , Medical University , Lublin , Poland.
  slot:
    index: 4
    item: Jünemann A
      type: Person
      first name: Anselm
      last name: Jünemann
      member of: c Department of Ophthalmology , University Eye Hospital , Rostock , Germany.
  slot:
    index: 5
    item: Rejdak R
      type: Person
      first name: Robert
      last name: Rejdak
      member of: a Department of General Ophthalmology , Medical University , Lublin , Poland.d Department of Experimental Pharmacology , Medical Research Centre, Polish Academy of Sciences , Warsaw , Poland.
created: 2018-4-25T06:00
date last updated: 2025-01-17
issued: 2018-12
dp: 2018 Dec
e ISSN: 1556-9535
has issn l: 1556-9527
issue: 4
has NLM journal title abbreviation: Cutan Ocul Toxicol
publication name: Cutaneous and ocular toxicology
language: eng
has national library of medicine journal id: 101266892
derived from: NLM
starting page: 319
ending page: 323
has place of publication: England
has primary subject term: D000431Q000009
has primary subject term: D009901Q000139Q000000981
has primary subject term: D012607Q000139Q000000981
has primary subject term: D058609Q000379
has subject term: D000328
has subject term: D001331
has subject term: D015331
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D011446
has subject term: D015203
has subject term: D014787
source: Cutan Ocul Toxicol. 2018-12;37(4):319-323.
volume: 37

Childhood hearing loss and established risk factors: What is the contribution of tobacco exposure prenatally or after birth?
pmid: 30211454
doi: 10.1111/ppe.12499
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Hoffman HJ
      type: Person
      first name: Howard J
      last name: Hoffman
      member of: National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD.
created: 2018-9-14T06:00
date last updated: 2025-01-17
issued: 2018-09
dp: 2018 09
e ISSN: 1365-3016
has issn l: 0269-5022
issue: 5
has NLM journal title abbreviation: Paediatr Perinat Epidemiol
publication name: Paediatric and perinatal epidemiology
language: eng
has national library of medicine journal id: 8709766
derived from: NLM
starting page: 439
ending page: 441
has place of publication: England
has primary subject term: D034381
has subject term: D002648
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D007564
has subject term: D011247
has subject term: D012189
has subject term: D012906
source: Paediatr Perinat Epidemiol. 2018-09;32(5):439-441.
volume: 32

An examination of the association between prenatal cocaine exposure and brain activation measures of arousal and attention in young adults: An fMRI study using the Attention Network Task.
pmid: 29953942
abstract: Prenatal drug exposure, including cocaine, alcohol, marijuana, and tobacco, is associated with deficits in behavioral regulation and attention. Using fMRI, the objective of this study was to characterize the association between prenatal cocaine exposure (PCE) and the underlying neural substrates associated with behavioral outcomes of attention. Forty-seven young adults were recruited for this study from the ongoing Maternal Health Practices and Child Development (MHPCD) Project, a longitudinal study of the effects of PCE on growth, behavior, and cognitive function. Three groups were compared: 1) prenatal exposure to cocaine, alcohol, marijuana, and tobacco (CAMT, n = 15), 2) prenatal exposure to alcohol, marijuana, and tobacco (AMT, n = 17), and 3) no prenatal exposure to drugs (Controls, n = 15). Subjects were frequency matched on gender, race, handedness, and 15-year IQ. This study used the theoretical model proposed by Posner and Peterson (1990), which posits three dissociable components of attention: alerting, orienting, and executive attention. Subjects completed a functional MRI (fMRI) scan while performing the Attention Network Task, a validated neuroimaging measure of the 3-network model of attention. Behavioral and fMRI data revealed no associations between PCE and task accuracy, speed of processing, or activation in key brain regions associated with each of the attention networks. The results of this study show that any subtle differences in brain function associated with PCE are not detectable using the ANT task and fMRI. These results should be interpreted in the context of other studies that have found associations between PCE and arousal with emotionally arousing stimuli, compared to this study that found no associations using emotionally neutral stimuli.
rights: Copyright © 2018 Elsevier Inc. All rights reserved.
has PII: S0892-0362(17)30221-0
doi: 10.1016/j.ntt.2018.06.004
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Willford JA
      type: Person
      first name: Jennifer A
      last name: Willford
      member of: Department of Psychology, Slippery Rock University, 1 Morrow Way, Slippery Rock, PA 16057, United States of America. Electronic address: jennifer.willford@sru.edu.
  slot:
    index: 2
    item: Singhabahu D
      type: Person
      first name: Dil
      last name: Singhabahu
      member of: Department of Mathematics, Slippery Rock University, 1 Morrow Way, Slippery Rock, PA 16057, United States of America. Electronic address: dil.singhabahu@sru.edu.
  slot:
    index: 3
    item: Herat A
      type: Person
      first name: Athula
      last name: Herat
      member of: Department of Physics, Slippery Rock University, 1 Morrow Way, Slippery Rock, PA 16057, United States of America. Electronic address: athula.herat@sru.edu.
  slot:
    index: 4
    item: Richardson GA
      type: Person
      first name: Gale A
      last name: Richardson
      member of: Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, United States of America. Electronic address: gar@pitt.edu.
created: 2018-6-29T06:00
date last updated: 2025-01-17
e ISSN: 1872-9738
has issn l: 0892-0362
has NLM journal title abbreviation: Neurotoxicol Teratol
publication name: Neurotoxicology and teratology
language: eng
has national library of medicine journal id: 8709538
derived from: NLM
starting page: 1
ending page: 10
has place of publication: United States
has primary subject term: D001143Q000502
has primary subject term: D001288Q000502
has primary subject term: D001921Q000503
has primary subject term: D003042Q000009
has primary subject term: D011297Q000503Q000523
has subject term: D002188Q000009
has subject term: D016022
has subject term: D004347
has subject term: D000431Q000009
has subject term: D005260
has subject term: D006801
has subject term: D008279
has subject term: D008297
has subject term: D059906
has subject term: D009483
has subject term: D011247
has subject term: D055815
source: Neurotoxicol Teratol. ;69():1-10.
volume: 69

Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.
pmid: 30828726
abstract: Lung adenocarcinoma (LADC) is the leading cause of cancer death worldwide. Nevertheless, syngeneic mouse models of the disease are sparse, and cell lines suitable for transplantable and immunocompetent mouse models of LADC remain unmet needs. We established multiple mouse LADC cell lines by repeatedly exposing two mouse strains (FVB, Balb/c) to the tobacco carcinogens urethane or diethylnitrosamine and by culturing out the resulting lung tumours for prolonged periods of time. Characterization of the resulting cell lines (n = 7) showed that they were immortal and phenotypically stable in vitro, and oncogenic, metastatic and lethal in vivo. The primary tumours that gave rise to the cell lines, as well as secondary tumours generated by transplantation of the cell lines, displayed typical LADC features, such as glandular architecture and mucin and thyroid transcription factor 1 expression. Moreover, these cells exhibited marked molecular similarity with human smokers' LADC, including carcinogen-specific Kras point mutations (KrasQ61R in urethane- and KrasQ61H in diethylnitrosamine-triggered cell lines) and Trp53 deletions and displayed stemness features. Interestingly, all cell lines overexpressed proliferin, a murine prolactin orthologue, which functioned as a lung tumour promoter. Furthermore, prolactin was overexpressed and portended poor prognosis in human LADC. In conclusion, we report the first LADC cell lines derived from mice exposed to tobacco carcinogens. These cells closely resemble human LADC and provide a valuable tool for the functional investigation of the pathobiology of the disease.
rights: © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: 5368948
doi: 10.1093/carcin/bgz047
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Kanellakis NI
      type: Person
      first name: Nikolaos I
      last name: Kanellakis
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 2
    item: Giannou AD
      type: Person
      first name: Anastasios D
      last name: Giannou
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 3
    item: Pepe MAA
      type: Person
      first name: Mario A A
      last name: Pepe
      member of: Lung Carcinogenesis Group, Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), Ludwig-Maximilian University and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Bavaria, Germany.
  slot:
    index: 4
    item: Agalioti T
      type: Person
      first name: Theodora
      last name: Agalioti
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 5
    item: Zazara DE
      type: Person
      first name: Dimitra E
      last name: Zazara
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 6
    item: Giopanou I
      type: Person
      first name: Ioanna
      last name: Giopanou
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 7
    item: Psallidas I
      type: Person
      first name: Ioannis
      last name: Psallidas
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 8
    item: Spella M
      type: Person
      first name: Magda
      last name: Spella
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 9
    item: Marazioti A
      type: Person
      first name: Antonia
      last name: Marazioti
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 10
    item: Arendt KAM
      type: Person
      first name: Kristina A M
      last name: Arendt
      member of: Lung Carcinogenesis Group, Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), Ludwig-Maximilian University and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Bavaria, Germany.
  slot:
    index: 11
    item: Lamort AS
      type: Person
      first name: Anne Sophie
      last name: Lamort
      member of: Lung Carcinogenesis Group, Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), Ludwig-Maximilian University and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Bavaria, Germany.
  slot:
    index: 12
    item: Champeris Tsaniras S
      type: Person
      first name: Spyridon
      last name: Champeris Tsaniras
      member of: Stem Cell Biology Laboratory, Department of Physiology, Faculty of Medicine, Greece.
  slot:
    index: 13
    item: Taraviras S
      type: Person
      first name: Stavros
      last name: Taraviras
      member of: Stem Cell Biology Laboratory, Department of Physiology, Faculty of Medicine, Greece.
  slot:
    index: 14
    item: Papadaki H
      type: Person
      first name: Helen
      last name: Papadaki
      member of: Department of Anatomy, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 15
    item: Lilis I
      type: Person
      first name: Ioannis
      last name: Lilis
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.
  slot:
    index: 16
    item: Stathopoulos GT
      type: Person
      first name: Georgios T
      last name: Stathopoulos
      member of: Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Rio, Achaia, Greece.Lung Carcinogenesis Group, Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), Ludwig-Maximilian University and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Bavaria, Germany.
created: 2019-3-5T06:00
date last updated: 2025-01-17
issued: 2019-11-25
dp: 2019 Nov 25
e ISSN: 1460-2180
has issn l: 0143-3334
issue: 11
has NLM journal title abbreviation: Carcinogenesis
publication name: Carcinogenesis
language: eng
has national library of medicine journal id: 8008055
derived from: NLM
starting page: 1352
ending page: 1362
has place of publication: England
has primary subject term: D000077192Q000139Q000235Q000378
has primary subject term: D045744
has primary subject term: D015972
has primary subject term: D008175Q000139Q000235Q000378
has primary subject term: D009154
has primary subject term: D011388Q000235
has subject term: D000818
has subject term: D063646
has subject term: D002273
has subject term: D004052Q000633
has subject term: D004195
has subject term: D011905Q000235
has subject term: D051379
has subject term: D000074482Q000235
has subject term: D016159Q000235
has subject term: D014520Q000633
source: Carcinogenesis. 2019-11-25;40(11):1352-1362.
volume: 40

Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link.
pmid: 31236278
abstract: Tobacco kills 6 million people annually and its global health costs are continuously rising. The main addictive component of every tobacco product is nicotine. Among the mechanisms by which nicotine, and its major metabolite, cotinine, contribute to heart disease is the renin-angiotensin-aldosterone system (RAAS) activation. This increases aldosterone production from the adrenals and circulating aldosterone levels. Aldosterone is a mineralocorticoid hormone with various direct harmful effects on the myocardium, including increased reactive oxygen species (ROS) generation, which contributes significantly to cardiac mitochondrial dysfunction and cardiac aging. Aldosterone is produced in the adrenocortical zona glomerulosa (AZG) cells in response to angiotensin II (AngII), activating its type 1 receptor (AT1R). The AT1R is a G protein-coupled receptor (GPCR) that leads to aldosterone biosynthesis and secretion, via signaling from both Gq/11 proteins and the GPCR adapter protein βarrestin1, in AZG cells. Adrenal βarrestin1 is essential for AngII-dependent adrenal aldosterone production, which aggravates heart disease. Since adrenal βarrestin1 is essential for raising circulating aldosterone in the body and tobacco compounds are also known to elevate aldosterone levels in smokers, accelerating heart disease progression, our central hypothesis is that nicotine and cotinine increase aldosterone levels to induce cardiac injury by stimulating adrenal βarrestin1. In the present review, we provide an overview of the current literature of the physiology and pharmacology of adrenal aldosterone production regulation, of the effects of tobacco on this process and, finally, of the effects of tobacco and aldosterone on cardiac structure and function, with a particular focus on cardiac mitochondrial function. We conclude our literature account with a brief experimental outline, as well as with some therapeutic perspectives of our pharmacological hypothesis, that is that adrenal βarre[cell cut: 2153 characters, first 2000 kept]
has PII: PRP2497
doi: 10.1002/prp2.497
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Solesio ME
      type: Person
      first name: Maria E
      last name: Solesio
      member of: Department of Basic Sciences New York University New York New York.
  slot:
    index: 2
    item: Mitaishvili E
      type: Person
      first name: Erna
      last name: Mitaishvili
      member of: Department of Basic Sciences New York University New York New York.
  slot:
    index: 3
    item: Lymperopoulos A
      type: Person
      first name: Anastasios
      last name: Lymperopoulos
      member of: Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences Nova Southeastern University College of Pharmacy Fort Lauderdale, Florida.
created: 2019-6-27T06:00
date last updated: 2025-01-17
issued: 2019-08
dp: 2019 08
created: 2019-6-26T06:00
e ISSN: 2052-1707
has issn l: 2052-1707
issue: 4
has NLM journal title abbreviation: Pharmacol Res Perspect
publication name: Pharmacology research & perspectives
language: eng
has national library of medicine journal id: 101626369
derived from: NLM
pg: e00497
has place of publication: United States
has primary subject term: D000450Q000378
has primary subject term: D006331Q000139Q000188Q000378
has primary subject term: D000071559Q000037Q000378
has subject term: D000311Q000378
has subject term: D003367Q000009
has subject term: D006801
has subject term: D058990
has subject term: D009538Q000009
source: Pharmacol Res Perspect. 2019-08;7(4):e00497.
volume: 7

Evaluation of drug information resources for drug-ethanol and drug-tobacco interactions.
pmid: 30598650
abstract: The research evaluated point-of-care drug interaction resources for scope, completeness, and consistency in drug-ethanol and drug-tobacco content.In a cross-sectional analysis, 2 independent reviewers extracted data for 108 clinically relevant interactions using 7 drug information resources (Clinical Pharmacology Drug Interaction Report, Facts & Comparisons eAnswers, Lexicomp Interactions, Micromedex Drug Interactions, Drug Interactions Analysis and Management, Drug Interaction Facts, and Stockley's Drug Interactions). Scope (presence of an entry), completeness (content describing mechanism, clinical effects, severity, level of certainty, and course of action for each present interaction; up to 1 point per assessed item for a total possible score of 5 points), and consistency (similarity among resources) were evaluated.Fifty-three drug-ethanol and 55 drug-tobacco interactions were analyzed. Drug-ethanol interaction entries were most commonly present in Lexicomp (84.9%), Clinical Pharmacology (83.0%), and Stockley's Drug Interactions (73.6%), compared to other resources (p<0.05). Drug-tobacco interactions were more often covered in Micromedex (56.4%), Stockley's Drug Interactions (56.4%), Drug Interaction Facts (43.6%), and Clinical Pharmacology (41.8%) (p<0.001). Overall completeness scores were higher for Lexicomp, Micromedex, Drug Interaction Facts, and Facts & Comparisons (median 5/5 points, interquartile range [IQR] 5 to 5, p<0.001) for drug-ethanol and for Micromedex (median 5/5 points, IQR 5 to 5, p<0.05) for drug-tobacco, compared to other resources. Drug Interaction Facts and Micromedex were among the highest scoring resources for both drug-ethanol (73.7%, 68.6%) and drug-tobacco (75.0%, 32.3%) consistency.Scope and completeness were high for drug-ethanol interactions, but low for drug-tobacco interactions. Consistency was highly variable across both interaction types.
has PII: jmla-107-62
doi: 10.5195/jmla.2019.549
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Beckett RD
      type: Person
      first name: Robert D
      last name: Beckett
      member of: Associate Professor of Pharmacy Practice and Director of the Drug Information Center, College of Pharmacy, Natural & Health Sciences, Manchester University, Fort Wayne, IN, rdbeckett@manchester.edu.
  slot:
    index: 2
    item: Stump CD
      type: Person
      first name: Curtis D
      last name: Stump
      member of: Doctor of Pharmacy Student, College of Pharmacy, Natural & Health Sciences, Manchester University, Fort Wayne, IN, cdstump2018@manchester.edu.
  slot:
    index: 3
    item: Dyer MA
      type: Person
      first name: Megan A
      last name: Dyer
      member of: Doctor of Pharmacy Student, College of Pharmacy, Natural & Health Sciences, Manchester University, Fort Wayne, IN, madyer2018@manchester.edu.
created: 2019-1-2T06:00
date last updated: 2025-01-17
issued: 2019-01
dp: 2019 Jan
e ISSN: 1558-9439
has issn l: 1536-5050
issue: 1
has NLM journal title abbreviation: J Med Libr Assoc
publication name: Journal of the Medical Library Association : JMLA
language: eng
has national library of medicine journal id: 101132728
derived from: NLM
starting page: 62
ending page: 71
has place of publication: United States
has primary subject term: D016208Q000592
has primary subject term: D004346Q000592
has primary subject term: D004347
has primary subject term: D000431Q000009
has subject term: D003430
has subject term: D006801
source: J Med Libr Assoc. 2019-01;107(1):62-71.
volume: 107

Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib.
pmid: 31002342
abstract: Sorafenib remains the standard care for patients with hepatocellular carcinoma (HCC) even though it has low antitumor efficacy. Protein neddylation is abnormally activated in many types of human cancer. However, whether dysregulation of neddylation is involved in HCC progression and whether targeting neddylation sensitizes HCC cells to sorafenib need to be ascertained. In the present study, it was demonstrated that high expression of neddylation components, neural precursor cell expressed, developmentally downregulated 8 (NEDD8) and NEDD8‑activating enzyme 1 (NAE1), were associated with poor survival of patients with HCC. Inhibition of neddylation by MLN4924, a small‑molecule inhibitor of NAE1, significantly inhibited HCC growth, reduced clonogenic survival, increased apoptosis, and decreased migration capacity. Sorafenib alone exhibited minimal anticancer efficacy. However, a combination of sorafenib with MLN4924 at a low concentration significantly enhanced the inhibition of cell proliferation and migration as well as the induction of apoptosis induced by sorafenib. In vivo HCC xenograft mouse models also showed that MLN4924 increased the antitumor efficacy of sorafenib. Mechanistically, MLN4924 enhanced the antitumor activity of sorafenib in HCC cells via upregulation of cullin‑RING E3 ubiquitin ligase (CRL)/Skp1‑Cullin1‑F box (SCF) E3 ubiquitin ligase substrates p21, p27, Deptor and IκBɑ. Taken together, these findings suggest that combination therapy of MLN4924 with sorafenib appears to present an additive effect with a maximal in the treatment of HCC.
doi: 10.3892/or.2019.7098
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Yang Z
      type: Person
      first name: Zelong
      last name: Yang
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 2
    item: Zhang J
      type: Person
      first name: Jie
      last name: Zhang
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 3
    item: Lin X
      type: Person
      first name: Xiaotong
      last name: Lin
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 4
    item: Wu D
      type: Person
      first name: Di
      last name: Wu
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 5
    item: Li G
      type: Person
      first name: Guixi
      last name: Li
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 6
    item: Zhong C
      type: Person
      first name: Chunlian
      last name: Zhong
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 7
    item: Fang L
      type: Person
      first name: Lei
      last name: Fang
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 8
    item: Jiang P
      type: Person
      first name: Peng
      last name: Jiang
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 9
    item: Yin L
      type: Person
      first name: Liangyu
      last name: Yin
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 10
    item: Zhang L
      type: Person
      first name: Leida
      last name: Zhang
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 11
    item: Bie P
      type: Person
      first name: Ping
      last name: Bie
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
  slot:
    index: 12
    item: Xie CM
      type: Person
      first name: Chuan-Ming
      last name: Xie
      member of: Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing 400038, P.R. China.
created: 2019-4-20T06:00
date last updated: 2025-01-17
issued: 2019-06
dp: 2019 Jun
e ISSN: 1791-2431
has issn l: 1021-335X
issue: 6
has NLM journal title abbreviation: Oncol Rep
publication name: Oncology reports
language: eng
has national library of medicine journal id: 9422756
derived from: NLM
starting page: 3257
ending page: 3269
has place of publication: Greece
has primary subject term: D006528Q000188Q000235Q000473
has primary subject term: D008113Q000188Q000235Q000473
has primary subject term: D000075687Q000235
has primary subject term: D044764Q000037Q000235
has subject term: D000818
has subject term: D000971Q000008
has subject term: D017209Q000187
has subject term: D002465Q000187
has subject term: D049109Q000187
has subject term: D003517Q000008
has subject term: D005260
has subject term: D015972Q000187
has subject term: D006801
has subject term: D008297
has subject term: D051379
has subject term: D008875
has subject term: http://id.nlm.nih.gov/mesh/D000072000
has subject term: D009363Q000235
has subject term: D011743Q000008
has subject term: D000077157Q000008
has subject term: D014452Q000235
has subject term: D023041
source: Oncol Rep. 2019-06;41(6):3257-3269.
volume: 41

Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression.
pmid: 30541597
abstract: The tetraspanins Tspan8 and CD151 promote metastasis, exosomes (Exo) being suggested to be important in the crosstalk between tumor and host. The contribution of Tspan8 and CD151 to host versus tumor-derived exosome (TEX) activities being not defined, we approached the questions using 3-methylcholanthrene-induced (MCA) tumors from wt, Tspan8ko, CD151ko and Tspan8/CD151 (db)ko mice, implanted into tetraspanin-competent and deficient hosts.Tumor growth and dissemination, hematopoiesis and angiogenesis were surveyed in wild type (wt), Tspan8ko, CD151ko and dbko mice bearing tetraspanin-competent and -deficient MCA tumors. In vitro studies using tumor cells, bone marrow cells (BMC) and endothelial cells (EC) elaborated the mechanism of serum (s)Exo- and TEX-induced target modulation.Tumors grew in autochthonous and syngeneic hosts differing in Tspan8- and/or CD151-competence. However, Tspan8ko- and/or CD151ko-tumor cell dissemination and settlement in metastatic organs was significantly reduced in the autochthonous host, and less severely in the wt-host. Impaired wt-MCA tumor dissemination in the ko-host confirmed a contribution of host- and tumor-Tspan8/-CD151 to tumor cell dissemination, delivery of sExo and TEX being severely impaired by a Tspan8ko/CD151ko. Coculturing tumor cells, BMC and EC with sExo and TEX revealed minor defects in epithelial mesenchymal transition and apoptosis resistance of ko tumors. Strongly reduced migratory and invasive capacity of Tspan8ko/CD151ko-MCA relies on distorted associations with integrins and CAM and missing Tspan8/CD151-promoted recruitment of proteases. The defects, differing between Tspan8ko- and CD151ko-MCA, were rescued by wt-TEX and, less efficiently Tspan8ko- and CD151ko-TEX. Minor defects in hematopoietic progenitor maturation were based on the missing association of hematopoietic growth factors /- receptors with CD151 and, less pronounced, Tspan8. Rescue of impaired angiogenesis in ko mice by wt-sExo and promotion of ang[cell cut: 2533 characters, first 2000 kept]
has PII: 10.1186/s13046-018-0961-6
doi: 10.1186/s13046-018-0961-6
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Zhao K
      type: Person
      first name: Kun
      last name: Zhao
      member of: Pancreas Section, University Hospital of Surgery, Ruprecht-Karls-University, Heidelberg, Germany.
  slot:
    index: 2
    item: Wang Z
      type: Person
      first name: Zhe
      last name: Wang
      member of: Pancreas Section, University Hospital of Surgery, Ruprecht-Karls-University, Heidelberg, Germany.Present Address: Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangdong, China.
  slot:
    index: 3
    item: Hackert T
      type: Person
      first name: Thilo
      last name: Hackert
      member of: Pancreas Section, University Hospital of Surgery, Ruprecht-Karls-University, Heidelberg, Germany.
  slot:
    index: 4
    item: Pitzer C
      type: Person
      first name: Claudia
      last name: Pitzer
      member of: Interdisciplinary Neurobehavioral Core, Institute of Pharmacology, Ruprecht-Karls-University, Heidelberg, Germany. claudia.pitzer@pharma.uni-heidelberg.de.
  slot:
    index: 5
    item: Zöller M
      type: Person
      first name: Margot
      last name: Zöller
      member of: Pancreas Section, University Hospital of Surgery, Ruprecht-Karls-University, Heidelberg, Germany. margot.zoeller@gmx.net.
created: 2018-12-14T06:00
date last updated: 2025-01-17
issued: 2018-12-12
dp: 2018 Dec 12
e ISSN: 1756-9966
has issn l: 0392-9078
issue: 1
has NLM journal title abbreviation: J Exp Clin Cancer Res
publication name: Journal of experimental & clinical cancer research : CR
language: eng
has national library of medicine journal id: 8308647
derived from: NLM
pg: 312
has place of publication: England
has primary subject term: D055354Q000378
has primary subject term: D006410Q000235
has primary subject term: D059470Q000235Q000378
has subject term: D000818
has subject term: D017209
has subject term: D006801
has subject term: D051379
has subject term: D008810
has subject term: D018345
has subject term: D009362
source: J Exp Clin Cancer Res. 2018-12-12;37(1):312.
volume: 37

Distract, delay, disrupt: examples of manufactured doubt from five industries.
pmid: 31271562
abstract: Manufactured doubt describes the efforts used by organizations or individuals to obscure the harmful effects of their products or actions by manipulating science. Although approaches to do so are widely used, relevant stakeholders are often unaware of these tactics. Here, we examine the strategies used in five cases of manufactured doubt: tobacco and adverse health; coal and black lung; Syngenta and the herbicide atrazine; the sugar industry and cardiovascular disease; and the Marshall Institute and climate change. By describing the tactics used in these cases, effective methods for identifying and countering instances of manufactured doubt can be generated.
has PII: /j/reveh.ahead-of-print/reveh-2019-0004/reveh-2019-0004.xml
doi: 10.1515/reveh-2019-0004
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Goldberg RF
      type: Person
      first name: Rebecca F
      last name: Goldberg
      member of: Graduate program in Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
  slot:
    index: 2
    item: Vandenberg LN
      type: Person
      first name: Laura N
      last name: Vandenberg
      member of: Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts - Amherst, 171C Goessmann, 686 N. Pleasant Street, Amherst, MA 01003, USA.
created: 2019-7-5T06:00
date last updated: 2025-01-17
issued: 2019-12-18
dp: 2019 Dec 18
e ISSN: 2191-0308
has issn l: 0048-7554
issue: 4
has NLM journal title abbreviation: Rev Environ Health
publication name: Reviews on environmental health
language: eng
has national library of medicine journal id: 0425754
derived from: NLM
starting page: 349
ending page: 363
has place of publication: Germany
has primary subject term: D001280Q000008
has primary subject term: D057231
has primary subject term: D003031Q000009
has primary subject term: D008192
has primary subject term: D007221Q000706
has primary subject term: D000073893Q000009
has subject term: D055008Q000209Q000523
has subject term: D002318Q000139
has subject term: D006540Q000009
has subject term: D006801
source: Rev Environ Health. 2019-12-18;34(4):349-363.
volume: 34

Hyaluronic acid in tobacco-exposed rats. Inflammatory reaction, and duration of effect1.
pmid: 30843935
abstract: To evaluate the hyaluronic acid (HA) inflammatory reaction, fibroblasts, fibrosis and duration of effect in the dorsal region of tobacco-exposed rats.Ten Wistar rats were divided into two groups: tobacco-exposed-group (TEG;n=5) and air-control-group (CG;n=5). The TEG animals were tobacco-exposed twice a day, 30-minutes/session, during 60 days. After this period, all animals received 0.1 mL HA subcutaneous injection in the dorsal area. The volume of HA was measured immediately after HA injection and weekly using a hand-caliper in nine weeks. After this period, all the animals were euthanized, and a specimen of was collected to evaluate inflammatory cells, fibroblasts, and fibrosis by HE.This study showed a higher inflammatory reaction in TEG than CG: inflammatory cell-count (CG: 1.07±0.9; TEG: 8.61±0.36, p<0.001); fibroblast count (CG: 2.92±0.17; TEG: 19.14±0.62, p<0.001), and fibrosis quantification (CG: 2.0; TEG: 3.75, p<0.001). The analysis of the HA volume in nine weeks in the dorsal region did not show a difference between groups (p=0.39).This study suggested that the HA injection in the TEG caused an increase in inflammatory cell count, fibroblast, and fibrosis quantification when compared to the CG. There was no difference in the duration of effect of HA between the groups.
has PII: S0102-86502019000200201
doi: 10.1590/s0102-8650201900202
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Camargo CP
      type: Person
      first name: Cristina Pires
      last name: Camargo
      member of: MD, Division of Plastic Surgery, Hospital das Clínicas, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, Universidade de São Paulo (USP), Brazil. Intellectual and scientific content of the study, interpretation of data, statistics analysis, manuscript writing, critical revision.
  slot:
    index: 2
    item: Frassei RD
      type: Person
      first name: Renan Dias
      last name: Frassei
      member of: Graduate student, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, USP, Sao Paulo-SP, Brazil. Acquisition, analysis and interpretation of data; technical procedures.
  slot:
    index: 3
    item: Silva DISBCE
      type: Person
      first name: Daniel Imbassahy de Sá Bittencourt Camara E
      last name: Silva
      member of: Graduate student, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, USP, Sao Paulo-SP, Brazil. Acquisition, analysis and interpretation of data; technical procedures.
  slot:
    index: 4
    item: Pfann RZ
      type: Person
      first name: Robert Zawadzki
      last name: Pfann
      member of: Graduate student, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, USP, Sao Paulo-SP, Brazil. Acquisition, analysis and interpretation of data; technical procedures.
  slot:
    index: 5
    item: Silva LCMD
      type: Person
      first name: Luiza de Campos Moreira da
      last name: Silva
      member of: Graduate student, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, USP, Sao Paulo-SP, Brazil. Acquisition, analysis and interpretation of data; technical procedures.
  slot:
    index: 6
    item: Morais-Besteiro J
      type: Person
      first name: Julio
      last name: Morais-Besteiro
      member of: MD, Division of Plastic Surgery, Hospital das Clínicas, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, Universidade de São Paulo (USP), Brazil. Intellectual and scientific content of the study, interpretation of data, statistics analysis, manuscript writing, critical revision.
  slot:
    index: 7
    item: Gemperli R
      type: Person
      first name: Rolf
      last name: Gemperli
      member of: PhD, Division of Plastic Surgery, Hospital das Clínicas, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, USP, Sao Paulo-SP, Brazil. Intellectual and scientific content of the study, interpretation of data, critical revision.
created: 2019-3-8T06:00
date last updated: 2025-01-17
issued: 2019-02-28
dp: 2019 Feb 28
e ISSN: 1678-2674
has issn l: 0102-8650
issue: 2
has NLM journal title abbreviation: Acta Cir Bras
publication name: Acta cirurgica brasileira
language: eng
has national library of medicine journal id: 9103983
derived from: NLM
pg: e201900202
has place of publication: Brazil
has primary subject term: D005347Q000187Q000473
has primary subject term: D006820Q000009
has primary subject term: D007249Q000139Q000473
has primary subject term: D019570Q000009
has primary subject term: D055675Q000009
has subject term: D000818
has subject term: D004195
has subject term: D004824Q000187Q000473
has subject term: D005355
has subject term: D008297
has subject term: D051381
has subject term: D017208
has subject term: D013997
source: Acta Cir Bras. 2019-02-28;34(2):e201900202.
volume: 34

Association between coffee, tobacco, and alcohol daily consumption and sleep/wake cycle: an actigraphy study in euthymic patients with bipolar disorders.
pmid: 32048536
abstract: Individuals with bipolar disorder (BD) have higher than average rates of coffee, tobacco and alcohol use. These substances may have deleterious effects on sleep quality and quantity, which may destabilize sleep/wake cycles and negatively impact the clinical course and prognosis of BD. The use of these substances may also be perceived as a self-medication attempt, for example, to induce sleep or to increase vigilance during the day. The objective of the current study was to investigate associations between the self-reported daily use of coffee, tobacco, and alcohol, and objective measures of sleep and activity patterns in adult individuals with BD. A sample of 147 euthymic individuals with BD were assessed for daily coffee, tobacco and alcohol consumption and 21 days of actigraphy monitoring. Actigraphic measures of sleep quantity and daytime activity were compared between groups classified as coffee+/coffee-, tobacco+/tobacco- and alcohol+/alcohol-, defined according to their current daily use. Then, we examined potential correlations between sleep/wake cycle parameters and the amount of daily consumption of each substance. Multivariable analyses identified associations between the use of coffee, tobacco, and alcohol and several sleep and activity parameters, such as between coffee, alcohol, and the relative amplitude of activity (respectively, p = .003 and p = .005), between alcohol and M10 onset (onset time of the 10 most active hours during the 24-h cycle) (p = .003), and between coffee and sleep duration (p = .047). This study supports the hypothesis that there is a relationship, whose direction would be bidirectional, between the daily use of these substances and the sleep/wake cycle in euthymic individuals with BD. These preliminary results require replications in other retrospective and prospective samples. They may have a clinical impact on psycho-education strategies to be proposed to individuals with BD.
doi: 10.1080/07420528.2020.1725542
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Gross G
      type: Person
      first name: Grégory
      last name: Gross
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Pôle de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy , Laxou, France.Faculté de Médecine, Université de Lorraine , France.
  slot:
    index: 2
    item: Maruani J
      type: Person
      first name: Julia
      last name: Maruani
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique des Hôpitaux de Paris (APHP) , Paris, France.Université de Paris , Paris, France.
  slot:
    index: 3
    item: Vorspan F
      type: Person
      first name: Florence
      last name: Vorspan
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique des Hôpitaux de Paris (APHP) , Paris, France.Université de Paris , Paris, France.
  slot:
    index: 4
    item: Benard V
      type: Person
      first name: Victoire
      last name: Benard
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Université de Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives , Lille, France.Université de Lille, CHRU Lille, Clinique de Psychiatrie, Unité CURE , Lille, France.Université de Lille, Hôpital Fontan CHRU , Lille, France.
  slot:
    index: 5
    item: Benizri C
      type: Person
      first name: Chloé
      last name: Benizri
      member of: INSERM U955, Equipe Psychiatrie Translationnelle , Créteil, France.
  slot:
    index: 6
    item: Brochard H
      type: Person
      first name: Héléna
      last name: Brochard
      member of: Pôle sectoriel, Centre Hospitalier Fondation Vallée , Gentilly, France.
  slot:
    index: 7
    item: Geoffroy PA
      type: Person
      first name: Pierre-Alexis
      last name: Geoffroy
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Université de Paris , Paris, France.Département de psychiatrie et de médecine addictologique, Assistance Publique des Hôpitaux de Paris (APHP), Centre Hospitalo-Universitaire Bichat-Claude Bernard , Paris, France.
  slot:
    index: 8
    item: Kahn JP
      type: Person
      first name: Jean-Pierre
      last name: Kahn
      member of: Pôle de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy , Laxou, France.Faculté de Médecine, Université de Lorraine , France.Clinique soins-études, Fondation Santé des Etudiants de France , Vitry-le-François, France.Fondation FondaMental , Créteil, France.
  slot:
    index: 9
    item: Yeim S
      type: Person
      first name: Sunthavy
      last name: Yeim
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique des Hôpitaux de Paris (APHP) , Paris, France.Université de Paris , Paris, France.
  slot:
    index: 10
    item: Leboyer M
      type: Person
      first name: Marion
      last name: Leboyer
      member of: INSERM U955, Equipe Psychiatrie Translationnelle , Créteil, France.Fondation FondaMental , Créteil, France.Faculté de Médecine, Université Paris Est Créteil , Créteil, France.AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie , Créteil, France.
  slot:
    index: 11
    item: Bellivier F
      type: Person
      first name: Frank
      last name: Bellivier
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique des Hôpitaux de Paris (APHP) , Paris, France.Université de Paris , Paris, France.Fondation FondaMental , Créteil, France.
  slot:
    index: 12
    item: Etain B
      type: Person
      first name: Bruno
      last name: Etain
      member of: INSERM U1144, Optimisation Thérapeutique en Neuropsychopharmacologie , Paris, France.Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, Assistance Publique des Hôpitaux de Paris (APHP) , Paris, France.Université de Paris , Paris, France.Fondation FondaMental , Créteil, France.
created: 2020-2-13T06:00
date last updated: 2025-01-17
issued: 2020-05
dp: 2020 05
e ISSN: 1525-6073
has issn l: 0742-0528
issue: 5
has NLM journal title abbreviation: Chronobiol Int
publication name: Chronobiology international
language: eng
has national library of medicine journal id: 8501362
derived from: NLM
starting page: 712
ending page: 722
has place of publication: England
has primary subject term: D001714
has primary subject term: D012893
has subject term: D056044
has subject term: D000328
has subject term: D000428
has subject term: D002940
has subject term: D003069Q000009
has subject term: D006801
has subject term: D011446
has subject term: D012189
has subject term: D012890
source: Chronobiol Int. 2020-05;37(5):712-722.
volume: 37

Xiaoyaosan exerts antidepressant-like effects by regulating the functions of astrocytes and EAATs in the prefrontal cortex of mice.
pmid: 31412844
abstract: Mounting evidence indicates that the cerebral cortex is an important physiological system of emotional activity, and its dysfunction may be the main cause of stress. Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS), which initiates rapid signal transmission in the synapse before its reuptake into the surrounding glia, specifically astrocytes (ASTs). The astrocytic excitatory amino acid transporters 1 (EAAT1) and 2 (EAAT2) are the major transporters that take up synaptic glutamate to maintain optimal extracellular glutamic levels, thus preventing accumulation in the synaptic cleft and ensuing excitotoxicity. Growing evidence has shown that excitotoxicity is associated with depression. Therefore, we hypothesized that the underlying antidepressant-like mechanism of Xiaoyaosan (XYS), a Chinese herbal formula, may be related to the regulation of astrocytic EAATs. Therefore, we studied the antidepressant mechanism of XYS on the basis of EAAT dysfunction in ASTs.Eighty adult C57BL/6 J mice were randomly divided into 4 groups: a control group, a chronic unpredictable mild stress (CUMS) group, a Xiaoyaosan (XYS) treatment group and a fluoxetine hydrochloride (Flu) treatment group. Except for the control group, mice in the other groups all received chronic unpredictable mild stress for 21 days. Mice in the control and CUMS groups received gavage administration with 0.5 mL of normal saline (NS) for 21 days, and mice in the XYS and Flu treatment groups were administered dosages of 0.25 g/kg/d and 2.6 mg/kg/d by gavage. The effects of XYS on the depressive-like behavioral tests, including the open field test (OFT), forced swimming test (FST) and sucrose preference test (SPT), were examined. The glutamate (Glu) concentrations of the prefrontal cortex (PFC) were detected with colorimetry. The morphology of neurons in the PFC was observed by Nissl staining. The expression of glial fibrillary acidic protein (GFAP), NeuN, EAAT1 and EAAT2 protei[cell cut: 3117 characters, first 2000 kept]
has PII: 10.1186/s12906-019-2613-6
doi: 10.1186/s12906-019-2613-6
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Liu Y
      type: Person
      first name: Yan
      last name: Liu
      member of: School of Pre-clinical Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.School of Pre-clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  slot:
    index: 2
    item: Ding XF
      type: Person
      first name: Xiu-Fang
      last name: Ding
      member of: School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing, 100029, China.
  slot:
    index: 3
    item: Wang XX
      type: Person
      first name: Xin-Xing
      last name: Wang
      member of: School of Pre-clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  slot:
    index: 4
    item: Zou XJ
      type: Person
      first name: Xiao-Juan
      last name: Zou
      member of: School of Pre-clinical Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
  slot:
    index: 5
    item: Li XJ
      type: Person
      first name: Xiao-Juan
      last name: Li
      member of: School of Pre-clinical Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing, 100029, China.
  slot:
    index: 6
    item: Liu YY
      type: Person
      first name: Yue-Yun
      last name: Liu
      member of: School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing, 100029, China.
  slot:
    index: 7
    item: Li J
      type: Person
      first name: Jie
      last name: Li
      member of: School of Pre-clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  slot:
    index: 8
    item: Qian XY
      type: Person
      first name: Xiu-Yun
      last name: Qian
      member of: School of Pre-clinical Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  slot:
    index: 9
    item: Chen JX
      type: Person
      first name: Jia-Xu
      last name: Chen
      member of: School of Pre-clinical Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China. chenjiaxu@hotmail.com.Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China. chenjiaxu@hotmail.com.School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing, 100029, China. chenjiaxu@hotmail.com.
created: 2019-8-16T06:00
date last updated: 2025-01-17
issued: 2019-08-14
dp: 2019 Aug 14
e ISSN: 1472-6882
has issn l: 1472-6882
issue: 1
has NLM journal title abbreviation: BMC Complement Altern Med
publication name: BMC complementary and alternative medicine
language: eng
has national library of medicine journal id: 101088661
derived from: NLM
pg: 215
has place of publication: England
has primary subject term: D000928Q000008
has primary subject term: D001253Q000187
has primary subject term: D003863Q000188Q000235Q000378
has primary subject term: D004365Q000008
has primary subject term: D027341Q000235Q000378
has primary subject term: D027342Q000235Q000378
has primary subject term: D017397Q000166Q000187
has subject term: D000818
has subject term: D001522
has subject term: D004195
has subject term: D005904Q000378
has subject term: D018698Q000378
has subject term: D006801
has subject term: D008297
has subject term: D051379
has subject term: D008810
source: BMC Complement Altern Med. 2019-08-14;19(1):215.
volume: 19

http://rdf.ncbi.nlm.nih.gov/pubmed/31813877
pmid: 31813877
abstract: Associations of GSTM1, GSTT1 and CYP1A1 gene variants with risk of developing nasopharyngeal cancer were evaluated in this case-control study, in which 130 cases along with 151 population-based healthy controls of Pashtun ethnicity from Khyber Pakhtunkhwa province of Pakistan were recruited. Socio-demographic data were obtained and blood samples were collected with informed consent for analysis. Specific RT-PCR and conventional PCR methods were used to detect CYP1A1 and GSTs, respectively, and results analyzed through SPSS version 20. Study showed that CYP1A1 homozygous (C/C) had an almost 4-fold increased risk for nasopharyngeal cancer; while heterozygous (T/C) had an almost 2 times increased risk. Overall the C allele is significantly associated with nasopharyngeal cancer as compared to T allele. Null genotypes of GSTM1 were having 3-fold increased risk; whereas null genotype of GSTT1 was having 2 times increased risk. Similarly, GSTM/GSTT both null genotype was having more than 5 times increased association. Presence of all three gene variants showed strong and significant association. Findings of the study suggest that presence of GSTM1 and/or GSTT1 null genotypes along with variant alleles of CYP1A1 are significant risk factors for nasopharyngeal cancer susceptibility in Pashtun population.
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Zakiullah -
      type: Person
      first name: -
      last name: Zakiullah
      member of: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  slot:
    index: 2
    item: Saeed M
      type: Person
      first name: Muhammad
      last name: Saeed
      member of: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  slot:
    index: 3
    item: Javed N
      type: Person
      first name: Nabila
      last name: Javed
      member of: Institute of Radiotherapy & Nuclear Medicine, Peshawar, Pakistan.
  slot:
    index: 4
    item: Khuda F
      type: Person
      first name: Fazli
      last name: Khuda
      member of: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
  slot:
    index: 5
    item: Ovais M
      type: Person
      first name: Muhammad
      last name: Ovais
      member of: Department of Biotechnology Quaid-i-Azam University, Islamabad, Pakistan.
created: 2019-12-10T06:00
date last updated: 2025-01-17
issued: 2019-09
dp: 2019 Sep
ISSN: 1011-601X
has issn l: 1011-601X
issue: 5
has NLM journal title abbreviation: Pak J Pharm Sci
publication name: Pakistan journal of pharmaceutical sciences
language: eng
has national library of medicine journal id: 9426356
derived from: NLM
starting page: 2107
ending page: 2116
has place of publication: Pakistan
has primary subject term: D019363Q000235
has primary subject term: D020022Q000235
has primary subject term: D005982Q000235
has primary subject term: D009303Q000235
has primary subject term: D011110Q000235
has subject term: D000328
has subject term: D000483
has subject term: D016022
has subject term: D005006Q000235
has subject term: D005260
has subject term: D005838
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D010154
has subject term: D012307
source: Pak J Pharm Sci. 2019-09;32(5):2107-2116.
title: Association of nasopharyngeal cancer risk with genetic polymorphisms of drug-metabolizing enzyme genes GSTM1, GSTT1 and CYP1A1 (rs4646903 variant), in tobacco addicted patients of Pashtun ethnicity of Khyber Pakhtunkhwa Province of Pakistan.
volume: 32

Bacterial catabolism of nicotine: Catabolic strains, pathways and modules.
pmid: 32311908
abstract: Nicotine, the major alkaloid in tobacco, is a toxic, carcinogenic, and addictive compound. In recent years, nicotine catabolism in prokaryotes, including the catabolic pathways for its degradation and the catabolic genes that encode the enzymes of these pathways, have been systemically investigated. In this review, the three known pathways for nicotine catabolism in bacteria are summarized: the pyridine pathway, the pyrrolidine pathway, and a variation of the pyridine and pyrrolidine pathway (VPP pathway). The three nicotine catabolic pathways appear to have evolved separately in three distantly related lineages of bacteria. However, the general mechanism for the breakdown of the nicotine molecule in all three pathways is conserved and can be divided into six major enzymatic steps or catabolic modules that involve hydroxylation of the pyridine ring, dehydrogenation of the pyrrolidine ring, cleavage of the side chain, cleavage of the pyridine ring, dehydrogenation of the side chain, and deamination of pyridine ring-lysis products. In addition to summarizing our current understanding of nicotine degradation pathways, we identified several potential nicotine-degrading bacteria whose genome sequences are in public databases by comparing the sequences of conserved catabolic enzymes. Finally, several uncharacterized genes that are colocalized with nicotine degradation genes and are likely to be involved in nicotine catabolism, including regulatory genes, methyl-accepting chemotaxis protein genes, transporter genes, and cofactor genes are discussed. This review provides a comprehensive overview of the catabolism of nicotine in prokaryotes and highlights aspects of the process that still require additional research.
rights: Copyright © 2020 Elsevier Inc. All rights reserved.
has PII: S0013-9351(20)30150-X
doi: 10.1016/j.envres.2020.109258
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Mu Y
      type: Person
      first name: Yang
      last name: Mu
      member of: Department of Microbiology, College of Life Sciences, Key Laboratory of Environmental Microbiology for Agriculture, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China; Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California, Davis, Davis, CA, USA.
  slot:
    index: 2
    item: Chen Q
      type: Person
      first name: Qing
      last name: Chen
      member of: College of Life Sciences, Zaozhuang University, Zaozhuang, 277160, China.
  slot:
    index: 3
    item: Parales RE
      type: Person
      first name: Rebecca E
      last name: Parales
      member of: Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California, Davis, Davis, CA, USA.
  slot:
    index: 4
    item: Lu Z
      type: Person
      first name: Zhenmei
      last name: Lu
      member of: College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
  slot:
    index: 5
    item: Hong Q
      type: Person
      first name: Qing
      last name: Hong
      member of: Department of Microbiology, College of Life Sciences, Key Laboratory of Environmental Microbiology for Agriculture, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China.
  slot:
    index: 6
    item: He J
      type: Person
      first name: Jian
      last name: He
      member of: Department of Microbiology, College of Life Sciences, Key Laboratory of Environmental Microbiology for Agriculture, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China.
  slot:
    index: 7
    item: Qiu J
      type: Person
      first name: Jiguo
      last name: Qiu
      member of: Department of Microbiology, College of Life Sciences, Key Laboratory of Environmental Microbiology for Agriculture, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: qiujiguo@njau.edu.cn.
  slot:
    index: 8
    item: Jiang J
      type: Person
      first name: Jiandong
      last name: Jiang
      member of: Department of Microbiology, College of Life Sciences, Key Laboratory of Environmental Microbiology for Agriculture, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: jiang_jjd@njau.edu.cn.
created: 2020-4-22T06:00
date last updated: 2025-01-17
issued: 2020-04
dp: 2020 04
e ISSN: 1096-0953
has issn l: 0013-9351
has NLM journal title abbreviation: Environ Res
publication name: Environmental research
language: eng
has national library of medicine journal id: 0147621
derived from: NLM
pg: 109258
has place of publication: Netherlands
has primary subject term: D001419Q000378
has primary subject term: D009538Q000378
has subject term: D001426
source: Environ Res. 2020-04;183():109258.
volume: 183

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.
pmid: 31804466
abstract: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately mimic the complexity of the HNSCC mutational landscape and tumor immune environment are urgently needed. Here, we report a mouse HNSCC model system that recapitulates the human tobacco-related HNSCC mutanome, in which tumors grow when implanted in the tongue of immunocompetent mice. These HNSCC lesions have similar immune infiltration and response rates to anti-PD-1 (≤20%) immunotherapy as human HNSCCs. Remarkably, we find that >70% of HNSCC lesions respond to intratumoral anti-CTLA-4. This syngeneic HNSCC mouse model provides a platform to accelerate the development of immunotherapeutic options for HNSCC.
has PII: 10.1038/s41467-019-13471-0
doi: 10.1038/s41467-019-13471-0
creator: OrderedList
  length: 19
  slot:
    index: 1
    item: Wang Z
      type: Person
      first name: Zhiyong
      last name: Wang
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.
  slot:
    index: 2
    item: Wu VH
      type: Person
      first name: Victoria H
      last name: Wu
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.Department of Pharmacology, University of California San Diego, La Jolla, CA, USA.
  slot:
    index: 3
    item: Allevato MM
      type: Person
      first name: Michael M
      last name: Allevato
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.Department of Pharmacology, University of California San Diego, La Jolla, CA, USA.
  slot:
    index: 4
    item: Gilardi M
      type: Person
      first name: Mara
      last name: Gilardi
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.
  slot:
    index: 5
    item: He Y
      type: Person
      first name: Yudou
      last name: He
      member of: Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
  slot:
    index: 6
    item: Luis Callejas-Valera J
      type: Person
      first name: Juan
      last name: Luis Callejas-Valera
      member of: Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD, USA.
  slot:
    index: 7
    item: Vitale-Cross L
      type: Person
      first name: Lynn
      last name: Vitale-Cross
      member of: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
  slot:
    index: 8
    item: Martin D
      type: Person
      first name: Daniel
      last name: Martin
      member of: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
  slot:
    index: 9
    item: Amornphimoltham P
      type: Person
      first name: Panomwat
      last name: Amornphimoltham
      member of: International College of Dentistry, Walailak University, Nakhon Si Thammarat, Thailand.
  slot:
    index: 10
    item: Mcdermott J
      type: Person
      first name: James
      last name: Mcdermott
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.
  slot:
    index: 11
    item: Yung BS
      type: Person
      first name: Bryan S
      last name: Yung
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.Department of Pharmacology, University of California San Diego, La Jolla, CA, USA.
  slot:
    index: 12
    item: Goto Y
      type: Person
      first name: Yusuke
      last name: Goto
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.
  slot:
    index: 13
    item: Molinolo AA
      type: Person
      first name: Alfredo A
      last name: Molinolo
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.
  slot:
    index: 14
    item: Sharabi AB
      type: Person
      first name: Andrew B
      last name: Sharabi
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
  slot:
    index: 15
    item: Cohen EEW
      type: Person
      first name: Ezra E W
      last name: Cohen
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.Department of Medicine, Division of Hematology-Oncology, University of California, San Diego, La Jolla, CA, USA.
  slot:
    index: 16
    item: Chen Q
      type: Person
      first name: Qianming
      last name: Chen
      member of: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
  slot:
    index: 17
    item: Lyons JG
      type: Person
      first name: J Guy
      last name: Lyons
      member of: Dermatology, Bosch Institute, University of Sydney, Camperdown, NSW, 2050, Australia.Cancer Services, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia.Centenary Institute, Camperdown, NSW, 2050, Australia.
  slot:
    index: 18
    item: Alexandrov LB
      type: Person
      first name: Ludmil B
      last name: Alexandrov
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA.Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
  slot:
    index: 19
    item: Gutkind JS
      type: Person
      first name: J Silvio
      last name: Gutkind
      member of: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, USA. sgutkind@ucsd.edu.Department of Pharmacology, University of California San Diego, La Jolla, CA, USA. sgutkind@ucsd.edu.
created: 2019-12-6T06:00
date last updated: 2025-01-17
issued: 2019-12-05
dp: 2019 12 05
e ISSN: 2041-1723
has issn l: 2041-1723
issue: 1
has NLM journal title abbreviation: Nat Commun
publication name: Nature communications
language: eng
has national library of medicine journal id: 101528555
derived from: NLM
pg: 5546
has place of publication: England
has primary subject term: D002294Q000139Q000628
has primary subject term: D006258Q000139Q000628
has primary subject term: D007167Q000379
has primary subject term: D000074324Q000627
has primary subject term: D009062Q000139Q000628
has subject term: D000818
has subject term: D000074322Q000627
has subject term: D045744
has subject term: D004195
has subject term: D006801
has subject term: D051379
source: Nat Commun. 2019-12-05;10(1):5546.
volume: 10

Use of Alcohol, Tobacco, and Caffeine and Suicide Attempts: Findings From a Nationally Representative Cross-sectional Study.
pmid: 32193974
abstract: In this study, the association between students' substance use and suicide attempts in the past 1 year was examined using secondary data from the 13th Korea Risk Behavior Web-based Survey. Participants were 7th- to 12th-grade students and 50.9% were male. A binominal logistic regression analysis was used to investigate the association between past experience of substance use (alcohol, tobacco, and caffeine) and suicide attempts after controlling for sociodemographic and psychological factors. Compared with no use, daily use of alcohol (odds ratio [OR] = 8.00), caffeine (OR = 2.13), and tobacco (OR = 1.41) was associated with increased odds of suicide attempts. These results indicate that school-based suicide prevention programs should cover awareness, surveillance, and treatment referral for these 3 substances. Moreover, mental health professionals should monitor intake of these substances when evaluating risk of suicide attempts in youth.
doi: 10.1177/2150132720913720
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Cho MS
      type: Person
      first name: Myong Sun
      last name: Cho
      member of: Ewha Womans University, Seoul, Republic of Korea.
created: 2020-3-21T06:00
date last updated: 2025-01-17
e ISSN: 2150-1327
has issn l: 2150-1319
has NLM journal title abbreviation: J Prim Care Community Health
publication name: Journal of primary care & community health
language: eng
has national library of medicine journal id: 101518419
derived from: NLM
pg: 2150132720913720
has place of publication: United States
has primary subject term: D000294
has subject term: D000293
has subject term: D002110Q000009
has subject term: D003430
has subject term: D006801
has subject term: D008297
has subject term: D012307
has subject term: D012309
has subject term: D013406
source: J Prim Care Community Health. ;11():2150132720913720.
volume: 11

Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice.
pmid: 32476407
abstract: Our early studies demonstrated an impressive chemopreventive efficacy of dihydromethysticin (DHM), unique in kava, against tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice in which DHM was supplemented in the diet. The current work was carried out to validate the efficacy, optimize the dosing schedule, and further elucidate the mechanisms using oral bolus dosing of DHM. The results demonstrated a dose-dependent chemopreventive efficacy of DHM (orally administered 1 h before each of the two NNK intraperitoneal injections, 1 week apart) against NNK-induced lung adenoma formation. Temporally, DHM at 0.8 mg per dose (∼32 mg per kg body weight) exhibited 100% lung adenoma inhibition when given 3 and 8 h before each NNK injection and attained >93% inhibition when dosed at either 1 or 16 h before each NNK injection. The simultaneous treatment (0 h) or 40 h pretreatment (-40 h) decreased lung adenoma burden by 49.8% and 52.1%, respectively. However, post-NNK administration of DHM (1-8 h after each NNK injection) was ineffective against lung tumor formation. In short-term experiments for mechanistic exploration, DHM treatment reduced the formation of NNK-induced O6-methylguanine (O6-mG, a carcinogenic DNA adduct in A/J mice) in the target lung tissue and increased the urinary excretion of NNK detoxification metabolites as judged by the ratio of urinary NNAL-O-gluc to free NNAL, generally in synchrony with the tumor prevention efficacy outcomes in the dose scheduling time-course experiment. Overall, these results suggest DHM as a potential chemopreventive agent against lung tumorigenesis in smokers, with O6-mG and NNAL detoxification as possible surrogate biomarkers.
doi: 10.1021/acs.chemrestox.0c00161
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Hu Q
      type: Person
      first name: Qi
      last name: Hu
      member of: Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
  slot:
    index: 2
    item: Corral P
      type: Person
      first name: Pedro
      last name: Corral
      member of: Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
  slot:
    index: 3
    item: Narayanapillai SC
      type: Person
      first name: Sreekanth C
      last name: Narayanapillai
      member of: Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 4
    item: Leitzman P
      type: Person
      first name: Pablo
      last name: Leitzman
      member of: Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 5
    item: Upadhyaya P
      type: Person
      first name: Pramod
      last name: Upadhyaya
      member of: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 6
    item: O'Sullivan MG
      type: Person
      first name: M Gerard
      last name: O'Sullivan
      member of: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota 55108, United States.
  slot:
    index: 7
    item: Hecht SS
      type: Person
      first name: Stephen S
      last name: Hecht
      member of: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 8
    item: Lu J
      type: Person
      first name: Junxuan
      last name: Lu
      member of: Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States.
  slot:
    index: 9
    item: Xing C
      type: Person
      first name: Chengguo
      last name: Xing
      member of: Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
created: 2020-6-2T06:00
date last updated: 2025-01-17
issued: 2020-07-20
dp: 2020 07 20
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 7
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 1980
ending page: 1988
has place of publication: United States
has primary subject term: D000236Q000517
has primary subject term: D016588Q000008
has primary subject term: D002074Q000633
has primary subject term: D002273Q000633
has primary subject term: D008175Q000517
has primary subject term: D009602Q000633
has primary subject term: D011753Q000008
has subject term: D000284
has subject term: D000818
has subject term: D063646Q000187
has subject term: D018736Q000187
has subject term: D019587
has subject term: D005260
has subject term: D008099Q000187Q000378
has subject term: D008168Q000187Q000378
has subject term: D008815
source: Chem Res Toxicol. 2020-07-20;33(7):1980-1988.
volume: 33

Impact of Atomizer Age and Flavor on In Vitro Toxicity of Aerosols from a Third-Generation Electronic Cigarette against Human Oral Cells.
pmid: 32909746
abstract: Electronic cigarettes (ECs) are categorized into generations which differ in terms of design, aerosol production, and customizability. Current and former smokers prefer third-generation devices that satisfy tobacco cravings more effectively than older generations. Recent studies indicate that EC aerosols from first- and second-generation devices contain reactive carbonyls and free radicals and can cause in vitro cytotoxicity. Third-generation ECs have not been adequately studied. Further, previous studies have focused on cells from the respiratory tract, whereas those of the oral cavity, which is exposed to high levels of EC aerosols, have been understudied. We quantified the production of reactive carbonyls and free radicals by a third-generation EC and investigated the induction of cytotoxicity and oxidative stress in normal and cancerous human oral cell lines using a panel of eight commercial EC liquids. We found that EC aerosols produced using a new atomizer contained formaldehyde, acetaldehyde, and acrolein, but did not contain detectable levels of free radicals. We found that EC aerosols generated from only one of the eight liquids tested using a new atomizer induced cytotoxicity against two human oral cells in vitro. Treatment of oral cells with the cytotoxic EC aerosol caused a concomitant increase in intracellular oxidative stress. As atomizer age increased with repeated use of the same atomizer, carbonyl production, radical emissions, and cytotoxicity increased. Overall, our results suggest that third-generation ECs may cause adverse effects in the oral cavity and normal EC use, which involves repeated use of the same atomizer to generate aerosol, may enhance the potential toxic effects of third-generation ECs.
doi: 10.1021/acs.chemrestox.0c00028
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ureña JF
      type: Person
      first name: José F
      last name: Ureña
      member of: Department of Food Science, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
  slot:
    index: 2
    item: Ebersol LA
      type: Person
      first name: Lauren A
      last name: Ebersol
      member of: Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
  slot:
    index: 3
    item: Silakov A
      type: Person
      first name: Alexey
      last name: Silakov
      member of: Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
  slot:
    index: 4
    item: Elias RJ
      type: Person
      first name: Ryan J
      last name: Elias
      member of: Department of Food Science, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
  slot:
    index: 5
    item: Lambert JD
      type: Person
      first name: Joshua D
      last name: Lambert
      member of: Department of Food Science, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
created: 2020-9-11T06:00
date last updated: 2025-01-17
issued: 2020-10-19
dp: 2020 10 19
created: 2020-9-10T12:19
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 10
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 2527
ending page: 2537
has place of publication: United States
has primary subject term: D000336Q000009
has primary subject term: D066300
has subject term: D002470Q000187
has subject term: D005609Q000009
has subject term: D006801
has subject term: D014407
source: Chem Res Toxicol. 2020-10-19;33(10):2527-2537.
volume: 33

Association between Telomere-Related Polymorphisms and the Risk of IPF and COPD as a Precursor Lesion of Lung Cancer: Findings from the Fukuoka Tobacco-Related Lung Disease (FOLD) Registry.
pmid: 32212792
abstract: Lung cancer coexisting with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) can lead to poor prognosis. Telomere-related polymorphisms may be implicated in the pathogenesis of these three lung diseases. As to elucidate the mechanism of lung cancer via IPF or COPD may enable early detection and early treatment of the disease, we firstly examined the association between telomere-related polymorphisms and the risk of IPF and COPD in a case-control study.A total of 572 patients with IPF (n = 155) or COPD (n = 417), who were derived from our on-going cohort study, and controls (n = 379), who were derived from our previous case-control study, were included in this study. Telomerase reverse transcriptase (TERT) rs2736100, telomere RNA component (TERC) rs1881984, and oligonucleotide/oligosaccharide-binding fold containing1 (OBFC1) rs11191865 were genotyped with real-time PCR using TaqMan fluorescent probes. Unconditional logistic regression was used to assess the adjusted odds ratios and 95% confidence intervals.TERT rs2736100 was significantly associated with the risk of IPF; increases in the number of this risk allele increased the risk of IPF (Ptrend = 0.008). Similarly, TERT rs2736100 was associated with the risk of COPD. In regard to the combined action of the three loci, increasing numbers of at-risk genotypes increased the risk of IPF in a dose-dependent manner (P trend=0.003).TERT rs2736100 was associated with the risks of both IPF and COPD in a Japanese population. A combination of the at-risk genotypes might be important to identify the population at risk for IPF more clearly.
doi: 10.31557/APJCP.2020.21.3.667
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Arimura-Omori M
      type: Person
      first name: Masako
      last name: Arimura-Omori
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 2
    item: Kiyohara C
      type: Person
      first name: Chikako
      last name: Kiyohara
      member of: Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University,Fukuoka,Japan.
  slot:
    index: 3
    item: Yanagihara T
      type: Person
      first name: Toyoshi
      last name: Yanagihara
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 4
    item: Yamamoto Y
      type: Person
      first name: Yuzo
      last name: Yamamoto
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 5
    item: Ogata-Suetsugu S
      type: Person
      first name: Saiko
      last name: Ogata-Suetsugu
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 6
    item: Harada E
      type: Person
      first name: Eiji
      last name: Harada
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 7
    item: Hamada N
      type: Person
      first name: Naoki
      last name: Hamada
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  slot:
    index: 8
    item: Tsuda T
      type: Person
      first name: Toru
      last name: Tsuda
      member of: Kirigaoka Tsuda Hospital, Fukuoka, Japan.
  slot:
    index: 9
    item: Takata S
      type: Person
      first name: Shohei
      last name: Takata
      member of: Division of Respiratory Medicine, National Hospital Organization, Fukuoka Higashi Medical Center, Fukuoka, Japan.
  slot:
    index: 10
    item: Shimabukuro I
      type: Person
      first name: Ikuko
      last name: Shimabukuro
      member of: Division of Respiratory Medicine, Kyushu Rosai Hospital, Fukuoka, Japan.
  slot:
    index: 11
    item: Nagata N
      type: Person
      first name: Nobuhiko
      last name: Nagata
      member of: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
  slot:
    index: 12
    item: Yatera K
      type: Person
      first name: Kazuhiro
      last name: Yatera
      member of: Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
  slot:
    index: 13
    item: Torii R
      type: Person
      first name: Ryo
      last name: Torii
      member of: Department of Respiratory Medicine, Wakamatsu Hospital of the University of Occupational and Environmental Health, Japan, Fukuoka, Japan.
  slot:
    index: 14
    item: Okamoto M
      type: Person
      first name: Masaki
      last name: Okamoto
      member of: Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
  slot:
    index: 15
    item: Fujita M
      type: Person
      first name: Masaki
      last name: Fujita
      member of: Department of Respiratory Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
  slot:
    index: 16
    item: Nakanishi Y
      type: Person
      first name: Yoichi
      last name: Nakanishi
      member of: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
created: 2020-3-28T06:00
date last updated: 2025-01-17
issued: 2020-03-01
dp: 2020 Mar 01
e ISSN: 2476-762X
has issn l: 1513-7368
issue: 3
has NLM journal title abbreviation: Asian Pac J Cancer Prev
publication name: Asian Pacific journal of cancer prevention : APJCP
language: eng
has national library of medicine journal id: 101130625
derived from: NLM
starting page: 667
ending page: 673
has place of publication: Thailand
has primary subject term: D054990Q000235
has primary subject term: D008175Q000235
has primary subject term: D020641
has primary subject term: D029424Q000235
has primary subject term: D019098Q000235
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D012042
has subject term: D012307
source: Asian Pac J Cancer Prev. 2020-03-01;21(3):667-673.
volume: 21

CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer.
pmid: 31937831
abstract: Oropharyngeal squamous cell carcinoma (OPSCC) incidence is increasing at a nearly epidemic rate, largely driven by the human papillomavirus (HPV). Despite the generally favorable clinical outcomes of patients with HPV driven (HPV+) OPSCC, a significant subset of HPV tumors associated with tobacco exposure have diminished treatment response and worse survival. The tumor immune microenvironment (TIME) has been shown to be a critical driver of treatment response and oncologic outcomes in OPSCC generally and HPV+ OPSCC more specifically. However, the impact of tobacco exposure on the TIME in OPSCC patients remains unclear. We analyzed the relationship between TIME, tobacco exposure and clinical outcomes in OPSCC patients (n = 143) with extensive tobacco exposure (median pack-years = 40). P16 overexpression, a surrogate marker of HPV association, was a strong predictor of relapse-free (RFS) and overall survival (OS) (p < 0.001, p < 0.001 respectively) regardless of tobacco exposure and associated strongly with differential infiltration of the tumor by both CD3 and CD8 lymphocytes measured via immunohistochemistry (p < 001, p < 0.001 respectively). CD3 and CD8 infiltration was a strong predictor of RFS and OS and associated strongly with disease stage (AJCC 8th Edition Staging Manual). Tobacco exposure correlated significantly (p < 0.001) with decreased CD8 infiltration in p16+ OPSCC tumors. Our findings demonstrate that the HPV+ OPSCC clinical outcomes are strongly correlated with the TIME, which is potentially modulated by tobacco exposure. Immunomodulatory strategies targeting this disease in smokers must take into consideration the potential modifying effects of tobacco exposure on treatment effectiveness and clinical outcomes.
has PII: 10.1038/s41598-019-57111-5
doi: 10.1038/s41598-019-57111-5
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Kemnade JO
      type: Person
      first name: J O
      last name: Kemnade
      member of: Department of Medicine, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 2
    item: Elhalawani H
      type: Person
      first name: H
      last name: Elhalawani
      member of: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  slot:
    index: 3
    item: Castro P
      type: Person
      first name: P
      last name: Castro
      member of: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 4
    item: Yu J
      type: Person
      first name: J
      last name: Yu
      member of: Bobby R. Alford Department of Otolaryngology- Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 5
    item: Lai S
      type: Person
      first name: S
      last name: Lai
      member of: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 6
    item: Ittmann M
      type: Person
      first name: M
      last name: Ittmann
      member of: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 7
    item: Mohamed ASR
      type: Person
      first name: A S R
      last name: Mohamed
      member of: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  slot:
    index: 8
    item: Lai SY
      type: Person
      first name: S Y
      last name: Lai
      member of: Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  slot:
    index: 9
    item: Fuller CD
      type: Person
      first name: C D
      last name: Fuller
      member of: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  slot:
    index: 10
    item: Sikora AG
      type: Person
      first name: A G
      last name: Sikora
      member of: Bobby R. Alford Department of Otolaryngology- Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
  slot:
    index: 11
    item: Sandulache VC
      type: Person
      first name: V C
      last name: Sandulache
      member of: Bobby R. Alford Department of Otolaryngology- Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA. vlad.sandulache@bcm.edu.Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. vlad.sandulache@bcm.edu.
created: 2020-1-16T06:00
date last updated: 2025-01-17
issued: 2020-01-14
dp: 2020 01 14
e ISSN: 2045-2322
has issn l: 2045-2322
issue: 1
has NLM journal title abbreviation: Sci Rep
publication name: Scientific reports
language: eng
has national library of medicine journal id: 101563288
derived from: NLM
pg: 243
has place of publication: England
has primary subject term: D016827Q000378
has primary subject term: D009959Q000139Q000276Q000378Q000821
has subject term: D002294Q000139Q000276Q000378Q000821
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D027383Q000502
has subject term: D012189
has subject term: D012306
has subject term: D059016Q000187Q000276
source: Sci Rep. 2020-01-14;10(1):243.
volume: 10

Effects of Tobacco on Biochemical Parameters in Healthy and Type 2 Diabetic Subjects.
pmid: 32479010
abstract: Diabetes and tobacco use are two of the largest public health challenges of our time. We aim to investigate the association between the two by comparing biochemical profiles of diabetic tobacco users (TUs) and tobacco nonus-ers (TNUs) to provide insight into the joint effect of tobacco and diabetes on body systems. This case-controlled study included 265 subjects, aged 18-60 yr, from the suburban population of Delhi, India. With the help of a questionnaire, participants are interviewed regarding their history of tobacco use. Results show association of tobacco use with elevated body-mass index, blood glucose levels, and insulin resistance in otherwise healthy and diabetic TUs. Even without previous history of coronary heart disease, total cholesterol and triglycerides are significantly further increased in TUs rather than in TNUs, indicative of initiation of lipid metabolism disorders. Tobacco use is also seen as a cause of oxidant/antioxidant imbalance in the body. Low serum albumin coupled with increased markers of inflammation and globulin levels is an indicator of generalized inflammation caused by tobacco's toxic effects. Creatinine levels are significantly higher in diabetic TUs, posing a threat to nephropathy progression. Evidence sufficiently infers that tobacco activates multiple biological pathways, through which the risk of metabolic disease increases. These factors may work in conjunction to increase risk of certain microvascular and macrovascular complications.
has PII: 44e1753e449f683a,0787d43a2c803c2a
doi: 10.1615/JEnvironPatholToxicolOncol.2020031383
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Upadhyay B
      type: Person
      first name: Bhumika
      last name: Upadhyay
      member of: Department of Biochemistry, HIMSR & HAHC Hospital, Jamia Hamdard, New Delhi 110062, India.
  slot:
    index: 2
    item: Dwivedi S
      type: Person
      first name: Shridhar
      last name: Dwivedi
      member of: Department of Medicine, National Heart Institute, New Delhi 110065, India.
  slot:
    index: 3
    item: Wajid S
      type: Person
      first name: Saima
      last name: Wajid
      member of: Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.
  slot:
    index: 4
    item: Jain SK
      type: Person
      first name: Swatantra Kumar
      last name: Jain
      member of: Department of Biochemistry, HIMSR & HAHC Hospital, Jamia Hamdard, New Delhi 110062, India.
created: 2020-6-2T06:00
date last updated: 2025-01-17
issued: 2020
dp: 2020
e ISSN: 2162-6537
has issn l: 0731-8898
issue: 1
has NLM journal title abbreviation: J Environ Pathol Toxicol Oncol
publication name: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
language: eng
has national library of medicine journal id: 8501420
derived from: NLM
starting page: 23
ending page: 37
has place of publication: United States
has primary subject term: D001786Q000032Q000187
has primary subject term: D015992
has primary subject term: D003924Q000097Q000503
has primary subject term: D007333
has subject term: D000328
has subject term: D016022
has subject term: D002947
has subject term: D005260
has subject term: D006801
has subject term: D007194
has subject term: D008297
has subject term: D008875
has subject term: D055815
source: J Environ Pathol Toxicol Oncol. 2020;39(1):23-37.
volume: 39

Use of Betel Quid in India from 2009 to 2017: An Epidemiological Analysis of the Global Adult Tobacco Survey (GATS).
pmid: 32569539
abstract: Background: Betel quid chewing is a deep-rooted practice in India and neighboring countries, which has migrated to other parts of the world. Betel leaf acts as a carrier for areca nut and most often, smokeless tobacco, both of which are carcinogenic, making betel quid a harmful product. Objectives: The first objective was to compare the prevalence of use of betel quid with tobacco from GATS-1 to GATS-2. The second was to study the association of use of betel quid with and without tobacco with different socio-economic groups (wealth quintiles) according to select background characteristics. Methods: This study used data from the Global Adult Tobacco Surveys (GATS), 2009-10 and 2016-17. Logistic regression with adjustment of co-variates (age, gender, residence and education) was used to study association of use of betel quid with different socio-economic groups. Results: Highest reduction (40 percent) was seen in use of betel quid with tobacco among male youth (15-24 years) over the two rounds of GATS. No change was seen in this form of use among females. The odds of use of betel quid with tobacco had a positive gradient with decreasing wealth quintiles. Use of betel quid without tobacco showed highest odds among participants with moderate levels of education. Conclusion: Health promotion interventions around harmful effects of betel quid with and without tobacco are needed for all genders from poorer populations with low education. Stress needs to be laid on universal population-level public health awareness campaigns about the carcinogenic properties of areca nut in betel quid.
doi: 10.1080/10826084.2020.1726393
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Arora M
      type: Person
      first name: Monika
      last name: Arora
      member of: Public Health Foundation of India, Gurugram, India.HRIDAY, New Delhi, India.
  slot:
    index: 2
    item: Shrivastava S
      type: Person
      first name: Surbhi
      last name: Shrivastava
      member of: HRIDAY, New Delhi, India.
  slot:
    index: 3
    item: Mishra VK
      type: Person
      first name: Vijay Kumar
      last name: Mishra
      member of: Public Health Foundation of India, Gurugram, India.
  slot:
    index: 4
    item: Mathur MR
      type: Person
      first name: Manu Raj
      last name: Mathur
      member of: Public Health Foundation of India, Gurugram, India.
created: 2020-6-23T06:00
date last updated: 2025-01-17
issued: 2020
dp: 2020
e ISSN: 1532-2491
has issn l: 1082-6084
issue: 9
has NLM journal title abbreviation: Subst Use Misuse
publication name: Substance use & misuse
language: eng
has national library of medicine journal id: 9602153
derived from: NLM
starting page: 1465
ending page: 1471
has place of publication: England
has primary subject term: D001114
has primary subject term: D019966Q000453
has subject term: D000328
has subject term: D005260
has subject term: D006306
has subject term: D006801
has subject term: D007194Q000453
has subject term: D008297
has subject term: D015995
source: Subst Use Misuse. 2020;55(9):1465-1471.
volume: 55

High lithium levels in tobacco, incidences of Parkinson's disease and melanoma: Mechanism of the association.
pmid: 32615500
has PII: S0306-9877(20)31453-5
doi: 10.1016/j.mehy.2020.110045
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Kawada T
      type: Person
      first name: Tomoyuiki
      last name: Kawada
      member of: Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. Electronic address: kawada@nms.ac.jp.
created: 2020-7-3T06:00
date last updated: 2025-01-17
issued: 2020-10
dp: 2020 10
e ISSN: 1532-2777
has issn l: 0306-9877
has NLM journal title abbreviation: Med Hypotheses
publication name: Medical hypotheses
language: eng
has national library of medicine journal id: 7505668
derived from: NLM
pg: 110045
has place of publication: United States
has primary subject term: D008545Q000453
has primary subject term: D010300
has subject term: D006801
has subject term: D015994
has subject term: D008094
source: Med Hypotheses. 2020-10;143():110045.
volume: 143

The science of spin: targeted strategies to manufacture doubt with detrimental effects on environmental and public health.
pmid: 33771171
abstract: Numerous groups, such as the tobacco industry, have deliberately altered and misrepresented knowable facts and empirical evidence to promote an agenda, often for monetary benefit, with consequences for environmental and public health. Previous research has explored cases individually, but none have conducted an in-depth comparison between cases. The purpose of this study was to compile a comprehensive list of tactics used by disparate groups and provide a framework for identifying further instances of manufactured doubt.We examined scholarly books, peer-reviewed articles, well-researched journalism pieces, and legal evidence related to five disparate industries and organizations selected for their destructive impacts on environmental and public health (tobacco, coal, and sugar industries, manufacturers of the pesticide Atrazine, and the Marshall Institute, an institute focused on climate change research, and other scientists from the era that associated with those in the Institute). These documents provided evidence for a list of tactics used to generate pro-industry spin and manufacture doubt about conferred harm. We then identified trends among sets of strategies that could explain their differential use or efficacy.We recognized 28 unique tactics used to manufacture doubt. Five of these tactics were used by all five organizations, suggesting that they are key features of manufactured doubt. The intended audience influences the strategy used to misinform, and logical fallacies contribute to their efficacy.This list of tactics can be used by others to build a case that an industry or group is deliberately manipulating information associated with their actions or products. Improved scientific and rhetorical literacy could be used to render them less effective, depending on the audience targeted, and ultimately allow for the protection of both environmental health and public health more generally.
has PII: 10.1186/s12940-021-00723-0
doi: 10.1186/s12940-021-00723-0
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Goldberg RF
      type: Person
      first name: Rebecca F
      last name: Goldberg
      member of: Graduate Program in Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, USA.
  slot:
    index: 2
    item: Vandenberg LN
      type: Person
      first name: Laura N
      last name: Vandenberg
      member of: Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, 171C Goessmann, 686 N. Pleasant Street, Amherst, MA, 01003, USA. lvandenberg@schoolph.umass.edu.
created: 2021-3-28T06:00
date last updated: 2025-01-17
issued: 2021-03-26
dp: 2021 03 26
created: 2021-3-27T05:30
e ISSN: 1476-069X
has issn l: 1476-069X
issue: 1
has NLM journal title abbreviation: Environ Health
publication name: Environmental health : a global access science source
language: eng
has national library of medicine journal id: 101147645
derived from: NLM
pg: 33
has place of publication: England
has primary subject term: D000047
has primary subject term: D003142
has primary subject term: D008192
has primary subject term: D004782
has primary subject term: D007221
has primary subject term: D011634
has subject term: D003031
has subject term: D006540
has subject term: D006801
has subject term: D033181
has subject term: D010575
has subject term: D011641
has subject term: http://id.nlm.nih.gov/mesh/D000073893
source: Environ Health. 2021-03-26;20(1):33.
volume: 20

Tobacco and Nicotine Cessation During Pregnancy.
pmid: 32732758
has PII: 00006250-202008000-00040
doi: 10.1097/AOG.0000000000004033
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Guerby P
      type: Person
      first name: Paul
      last name: Guerby
      member of: Department of Gynecology and Obstetrics, Paule de Viguier Hospital, CHU Toulouse, INSERM UMR 1048, I2MC, Université de Toulouse, Toulouse, France.
  slot:
    index: 2
    item: Garabedian C
      type: Person
      first name: Charles
      last name: Garabedian
      member of: Department of Obstetrics, CHU Lille, University of Lille, ULR 2694-METRICS, Lille, France.
  slot:
    index: 3
    item: Berveiller P
      type: Person
      first name: Paul
      last name: Berveiller
      member of: Department of Obstetrics and Gynecology, Poissy-Saint-Germain Hospital, Poissy, France.
  slot:
    index: 4
    item: Legendre G
      type: Person
      first name: Guillaume
      last name: Legendre
      member of: Department of Gynecology & Obstetrics, Angers University Hospital (CHU d'Angers), Angers, France.
  slot:
    index: 5
    item: Grangé G
      type: Person
      first name: Gilles
      last name: Grangé
      member of: Department of Obstetrics, Port-Royal Maternity Unit, Paris, Hôpitaux Universitaires Paris Centre, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
  slot:
    index: 6
    item: Berlin I
      type: Person
      first name: Ivan
      last name: Berlin
      member of: Département de Pharmacologie, Hôpital Pitié-Salpêtrière, Paris, France; and Centre Universitaire de Médecine Générale et Santé Publique, UNISANTE, Université de Lausanne, Switzerland.
creator: CNGOF and SFT Expert Report and Guidelines Group
created: 2020-8-1T06:00
date last updated: 2025-01-17
issued: 2020-08
dp: 2020 08
e ISSN: 1873-233X
has issn l: 0029-7844
issue: 2
has NLM journal title abbreviation: Obstet Gynecol
publication name: Obstetrics and gynecology
language: eng
has national library of medicine journal id: 0401101
derived from: NLM
starting page: 428
ending page: 429
has place of publication: United States
has primary subject term: D009538Q000009
has primary subject term: D016540
has subject term: D005260
has subject term: D006801
has subject term: D011247
has subject term: D061485
source: Obstet Gynecol. 2020-08;136(2):428-429.
volume: 136

Tribological behavior of dental restorative composites in chewable tobacco environment.
pmid: 32643528
abstract: This study investigates the effect of smokeless tobacco on the tribological properties of two commercially used dental composite materials: Tetric N-Ceram and Z350 Dentin shade. It is to evaluate the effect of smokeless tobacco on the wear properties of two dental composite materials after some stipulated period. The wear test was conducted on pin-on-disk tribometer in the presence of artificial saliva under different loading conditions of 10, 15 and 20 N. The pins of the dental composite material were immersed in tobacco solution. The tribological behavior was studied after 2 days, 3.5 days, 6 days, 15 days and 1 month which represented the real conditions for the contact of 1 week, 2 weeks, 1 month, 2 months and 5 months, respectively, between the dental material and the tobacco solution. Under different loading conditions, Z350 Dentin material exhibited much less wear than the Tetric N-Ceram material in the presence of synthetic saliva for the specimen with or without tobacco immersion. The microstructure of the pin surface was inspected using scanning electron microscopy.
doi: 10.1177/0954411920940829
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Suryawanshi AS
      type: Person
      first name: Abhijeet S
      last name: Suryawanshi
      member of: School of Mechanical Engineering (SMEC), VIT, Vellore, India.
  slot:
    index: 2
    item: Behera N
      type: Person
      first name: Niranjana
      last name: Behera
      member of: School of Mechanical Engineering (SMEC), VIT, Vellore, India.
created: 2020-7-10T06:00
date last updated: 2025-01-17
issued: 2020-10
dp: 2020 Oct
e ISSN: 2041-3033
has issn l: 0954-4119
issue: 10
has NLM journal title abbreviation: Proc Inst Mech Eng H
publication name: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
language: eng
has national library of medicine journal id: 8908934
derived from: NLM
starting page: 1106
ending page: 1112
has place of publication: England
has primary subject term: D003188
has subject term: D003764
has subject term: D008422
has subject term: D008855
has subject term: D013499
source: Proc Inst Mech Eng H. 2020-10;234(10):1106-1112.
volume: 234

Early sexual initiation and risky sexual practices among alcohol- and tobacco-using young adults in Taiwan: mediation analysis of preceding-sex use of illicit drugs.
pmid: 33143679
abstract: As early sexual initiation is increasingly common in East Asia, we examined its relations to risky sexual practices in alcohol- and tobacco-using individuals in Taiwan and evaluated whether the associations were mediated through preceding-sex use of illicit drugs.Participants, recruited from alcohol- and tobacco-using adults aged 18 to 50 in Taipei through respondent-driven sampling (N = 1115), completed a computer-assisted self-interview covering questions on substance use and sexual experiences. In a subsample of 916 participants who had had sexual experience (median age 27), we examined the relations of early sexual initiation (< 16 years) to multiple sexual partners, casual sex, group sex, and rare condom use. Causal mediation analyses were conducted to examine whether illicit drug use preceding sex mediated these associations.Around 9.3% reported early sexual initiation and the prevalence of risky sexual practices ranged from 7% (group sex) to 47% (rare condom use). Early initiators had a higher prevalence of regular binge drinking, illicit drug use, and risky sexual practices. In the multivariable analyses, higher odds of multiple sexual partners, casual sex, and group sex were consistently associated with early sexual initiation, gender, and their interaction. Mediation through preceding-sex use of illicit drugs was found between early sexual initiation and the three risky sexual practices, with the proportions mediated ranging from 17 to 19%.Early sexual initiators were more likely to engage in risky sexual practices and preceding-sex use of illicit drugs partially explained this relationship, calling for more attention to this population's sexual health.
has PII: 10.1186/s12889-020-09777-0
doi: 10.1186/s12889-020-09777-0
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Wu TL
      type: Person
      first name: Tat Leong
      last name: Wu
      member of: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
  slot:
    index: 2
    item: Ting TT
      type: Person
      first name: Te-Tien
      last name: Ting
      member of: School of Big Data Management, Soochow University, Taipei, Taiwan.
  slot:
    index: 3
    item: Chen CY
      type: Person
      first name: Chuan-Yu
      last name: Chen
      member of: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
  slot:
    index: 4
    item: Su LW
      type: Person
      first name: Lien-Wen
      last name: Su
      member of: Kunming Prevention and Control Center, Taipei City Hospital, Taipei, Taiwan.
  slot:
    index: 5
    item: Chen WJ
      type: Person
      first name: Wei J
      last name: Chen
      member of: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. wjchen@ntu.edu.tw.Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan. wjchen@ntu.edu.tw.Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. wjchen@ntu.edu.tw.Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. wjchen@ntu.edu.tw.
created: 2020-11-5T06:00
date last updated: 2025-01-17
issued: 2020-11-03
dp: 2020 Nov 03
created: 2020-11-4T05:31
e ISSN: 1471-2458
has issn l: 1471-2458
issue: 1
has NLM journal title abbreviation: BMC Public Health
publication name: BMC public health
language: eng
has national library of medicine journal id: 100968562
derived from: NLM
pg: 1647
has place of publication: England
has primary subject term: D013287
has subject term: D000293
has subject term: D000328
has subject term: D017280
has subject term: D003430
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000081983
has subject term: D008875
has subject term: D012309
has subject term: D012725
has subject term: D012747
has subject term: D013624Q000453
has subject term: D055815
source: BMC Public Health. 2020-11-03;20(1):1647.
volume: 20

British American Tobacco's 'Glo Sens' promotion with K-pop.
pmid: 32769211
has PII: tobaccocontrol-2020-055686
doi: 10.1136/tobaccocontrol-2020-055686
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Yi J
      type: Person
      first name: Jeeeun
      last name: Yi
      member of: Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
  slot:
    index: 2
    item: Kim J
      type: Person
      first name: Jinyoung
      last name: Kim
      member of: Southern Gyeonggi Regional Smoking Cessation Centre, Hallym University, Anyang, Gyeonggi-do, Republic of Korea.
  slot:
    index: 3
    item: Lee S
      type: Person
      first name: Sungkyu
      last name: Lee
      member of: National Tobacco Control Centre, Korea Health Promotion Institute, Seoul, Republic of Korea wwwvince77@gmail.com.
created: 2020-8-10T06:00
date last updated: 2025-01-17
issued: 2021-09
dp: 2021 09
e ISSN: 1468-3318
has issn l: 0964-4563
issue: 5
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 594
ending page: 596
has place of publication: England
has primary subject term: D019460
has subject term: D006801
has subject term: D040541
has subject term: D014481
source: Tob Control. 2021-09;30(5):594-596.
volume: 30

Big Tobacco's Predictable Prebudget Tantrums in Pakistan.
pmid: 33034343
has PII: 5920056
doi: 10.1093/ntr/ntaa191
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Khan Z
      type: Person
      first name: Zohaib
      last name: Khan
      member of: Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan.Office of Research, Innovation & Commercialization, Khyber Medical University, Peshawar, Pakistan.
  slot:
    index: 2
    item: Sheikh Z
      type: Person
      first name: Zaineb
      last name: Sheikh
      member of: Department for Health, Tobacco Control Research Group (TCRG), University of Bath, Bath, UK.
  slot:
    index: 3
    item: Khokhar M
      type: Person
      first name: Mariam
      last name: Khokhar
      member of: Department of Health Sciences, University of York, York, UK.
  slot:
    index: 4
    item: Islam Z
      type: Person
      first name: Ziauddin
      last name: Islam
      member of: Tobacco Control Cell, Ministry of National Health Services Regulations and Coordination, Government of Pakistan, Islamabad, Pakistan.
  slot:
    index: 5
    item: Gallagher A
      type: Person
      first name: Allen
      last name: Gallagher
      member of: Department for Health, Tobacco Control Research Group (TCRG), University of Bath, Bath, UK.
created: 2020-10-10T06:00
date last updated: 2025-01-17
issued: 2021-08-04
dp: 2021 08 04
created: 2020-10-9T08:37
e ISSN: 1469-994X
has issn l: 1462-2203
issue: 8
has NLM journal title abbreviation: Nicotine Tob Res
publication name: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
language: eng
has national library of medicine journal id: 9815751
derived from: NLM
starting page: 1444
ending page: 1445
has place of publication: England
has primary subject term: D019460
has subject term: D006801
has subject term: D010154Q000453
has subject term: http://id.nlm.nih.gov/mesh/D000074606
source: Nicotine Tob Res. 2021-08-04;23(8):1444-1445.
volume: 23

Tobacco, cannabis, and liquorice: Hidden players altering albendazole metabolism in patients with hepatic alveolar echinococcosis.
pmid: 33309328
has PII: S0168-8278(20)33749-1
doi: 10.1016/j.jhep.2020.10.032
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Bresson-Hadni S
      type: Person
      first name: Solange
      last name: Bresson-Hadni
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Centre National de Référence Echinococcoses, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; UMR 6249, Chronoenvironnement, Université de Franche-Comté, 25030 Besançon, France; Services d'Hepato-Gastroenterologie et; de Médecine Tropicale et Humanitaire, Hôpitaux Universitaires de Genève, Suisse. Electronic address: sbresson@chu-besancon.fr.
  slot:
    index: 2
    item: Montange D
      type: Person
      first name: Damien
      last name: Montange
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Laboratoire de Pharmacologie Clinique, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 3
    item: Richou C
      type: Person
      first name: Carine
      last name: Richou
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Service d'Hépatologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 4
    item: Brumpt E
      type: Person
      first name: Eléonore
      last name: Brumpt
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Service de Radiologie Viscérale, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 5
    item: Fillion A
      type: Person
      first name: Aurélie
      last name: Fillion
      member of: Service de Maladies Infectieuses, Centre Hospitalier Chalon sur Saône, France.
  slot:
    index: 6
    item: Bartholomot B
      type: Person
      first name: Brigitte
      last name: Bartholomot
      member of: Cabinet de Radiologie des Hauts de Chazal, Besançon, France.
  slot:
    index: 7
    item: Blagosklonov O
      type: Person
      first name: Oleg
      last name: Blagosklonov
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Service de Médecine Nucléaire, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 8
    item: Delabrousse E
      type: Person
      first name: Eric
      last name: Delabrousse
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Service de Radiologie Viscérale, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 9
    item: Grenouillet F
      type: Person
      first name: Frédéric
      last name: Grenouillet
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; UMR 6249, Chronoenvironnement, Université de Franche-Comté, 25030 Besançon, France; Sérologie Infectieuse, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 10
    item: Vuitton DA
      type: Person
      first name: Dominique-Angèle
      last name: Vuitton
      member of: Centre National de Référence Echinococcoses, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France.
  slot:
    index: 11
    item: Millon L
      type: Person
      first name: Laurence
      last name: Millon
      member of: Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; Centre National de Référence Echinococcoses, Centre Hospitalier Régional Universitaire de Besançon, Besançon, France; UMR 6249, Chronoenvironnement, Université de Franche-Comté, 25030 Besançon, France.
created: 2020-12-15T06:00
date last updated: 2025-01-17
issued: 2021-02
dp: 2021 02
created: 2020-12-14T10:12
e ISSN: 1600-0641
has issn l: 0168-8278
issue: 2
has NLM journal title abbreviation: J Hepatol
publication name: Journal of hepatology
language: eng
has national library of medicine journal id: 8503886
derived from: NLM
starting page: 471
ending page: 473
has place of publication: Netherlands
has primary subject term: D015766Q000008Q000493
has primary subject term: D002188Q000378
has primary subject term: D004347
has primary subject term: D016903Q000379
has primary subject term: D004444Q000097Q000000981Q000188
has primary subject term: D006035Q000378
has subject term: D000328
has subject term: D000977Q000008Q000493
has subject term: D003577Q000378
has subject term: D004305
has subject term: D005260
has subject term: D006801
has subject term: D008099Q000000981Q000469
has subject term: D008279Q000379
has subject term: D008297
has subject term: D008875
has subject term: D049268Q000379
source: J Hepatol. 2021-02;74(2):471-473.
volume: 74

FAS and FASL variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients.
pmid: 32628088
abstract: Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of TP53 c.215G > C, FAS c.-671A > G, FAS c.-1378G > A, FASL c.-844 C > T, CASP3 c.-1191A > G, and CASP3 c.-182-247G > T single nucleotide variants in toxicity, response rate, and survival of cisplatin chemoradiation-treated head and neck squamous cell carcinoma patients. Genomic DNA was analyzed by polymerase chain reaction for genotyping. Differences between groups of patients were analyzed by chi-square test or Fisher's exact test, multiple logistic regression analysis, and Cox hazards model. One hundred nine patients with head and neck squamous cell carcinoma were enrolled in study. All patients were smokers and/or alcoholics. Patients with FAS c.-671GG genotype, FAS c.-671AG or GG genotype, and FASL c.-844CC genotype had 5.52 (95% confidence interval (CI): 1.42-21.43), 4.03 (95% CI: 1.51-10.79), and 5.77 (95% CI: 1.23-27.04) more chances of presenting chemoradiation-related anemia of grades 2-4, lymphopenia of grade 3 or 4, and ototoxicity of all grades, respectively, than those with the remaining genotypes. FAS c.-671GG genotype was also seen as an independent predictor of shorter event-free survival (hazard ratio (HR): 2.05; P = 0.007) and overall survival (HR: 1.83; P = 0.02) in our head and neck squamous cell carcinoma patients. These findings present, for the first time, preliminary evidence that inherited abnormalities in apoptosis pathway, related to FAS c.-671A > G and FASL c.-844 C > T single nucleotide variants, can alter toxicity and survival of tobacco- and alcohol-related head and neck squamous cell carcinoma patients homogeneously treated with cisplatin chemoradiation.
doi: 10.1177/1010428320938494
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Costa EFD
      type: Person
      first name: Ericka Francislaine Dias
      last name: Costa
      member of: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 2
    item: Lima TRP
      type: Person
      first name: Tathiane Regine Penna
      last name: Lima
      member of: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 3
    item: Lopes-Aguiar L
      type: Person
      first name: Leisa
      last name: Lopes-Aguiar
      member of: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 4
    item: Nogueira GAS
      type: Person
      first name: Guilherme Augusto Silva
      last name: Nogueira
      member of: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 5
    item: Visacri MB
      type: Person
      first name: Marília Berlofa
      last name: Visacri
      member of: Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 6
    item: Quintanilha JCF
      type: Person
      first name: Julia Coelho França
      last name: Quintanilha
      member of: Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 7
    item: Pincinato EC
      type: Person
      first name: Eder Carvalho
      last name: Pincinato
      member of: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 8
    item: Calonga L
      type: Person
      first name: Luciane
      last name: Calonga
      member of: Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 9
    item: Mariano FV
      type: Person
      first name: Fernanda Viviane
      last name: Mariano
      member of: Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 10
    item: Altemani AMAM
      type: Person
      first name: Albina Messias de Almeida Milani
      last name: Altemani
      member of: Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 11
    item: Altemani JMC
      type: Person
      first name: João Maurício Carrasco
      last name: Altemani
      member of: Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 12
    item: Moriel P
      type: Person
      first name: Patrícia
      last name: Moriel
      member of: Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 13
    item: Chone CT
      type: Person
      first name: Carlos Takahiro
      last name: Chone
      member of: Department of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 14
    item: Ramos CD
      type: Person
      first name: Celso Dario
      last name: Ramos
      member of: Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  slot:
    index: 15
    item: Lima CSP
      type: Person
      first name: Carmen Silvia Passos
      last name: Lima
      member of: Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
created: 2020-7-7T06:00
date last updated: 2025-01-17
issued: 2020-07
dp: 2020 Jul
e ISSN: 1423-0380
has issn l: 1010-4283
issue: 7
has NLM journal title abbreviation: Tumour Biol
publication name: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
language: eng
has national library of medicine journal id: 8409922
derived from: NLM
pg: 1010428320938494
has place of publication: Netherlands
has primary subject term: D053222Q000235
has primary subject term: D000077195Q000139Q000188Q000235Q000532
has primary subject term: D019014Q000235
has subject term: D000328
has subject term: D000368
has subject term: D000438Q000009
has subject term: D059248Q000009
has subject term: D002945Q000008Q000009
has subject term: D064420Q000209Q000235Q000473
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D020641Q000235
has subject term: D011379
has subject term: D016159Q000235
source: Tumour Biol. 2020-07;42(7):1010428320938494.
volume: 42

Letter to the Editor: Cancer After Liver Transplant: Don't Forget Tobacco and Tacrolimus.
pmid: 33991352
doi: 10.1002/hep.31899
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Meunier L
      type: Person
      first name: Lucy
      last name: Meunier
      member of: Department of Hepatogastroenterology, Hepatology and Liver Transplant Unit, Saint Eloi Hospital, University of Montpellier, Montpellier, France.
  slot:
    index: 2
    item: Faure S
      type: Person
      first name: Stéphanie
      last name: Faure
      member of: Department of Hepatogastroenterology, Hepatology and Liver Transplant Unit, Saint Eloi Hospital, University of Montpellier, Montpellier, France.
  slot:
    index: 3
    item: Meszaros M
      type: Person
      first name: Magdalena
      last name: Meszaros
      member of: Department of Hepatogastroenterology, Hepatology and Liver Transplant Unit, Saint Eloi Hospital, University of Montpellier, Montpellier, France.
created: 2021-5-16T06:00
date last updated: 2025-01-17
issued: 2021-11
dp: 2021 11
created: 2021-5-15T12:10
e ISSN: 1527-3350
has issn l: 0270-9139
issue: 5
has NLM journal title abbreviation: Hepatology
publication name: Hepatology (Baltimore, Md.)
language: eng
has national library of medicine journal id: 8302946
derived from: NLM
starting page: 2912
ending page: 2913
has place of publication: United States
has primary subject term: D016031
has primary subject term: D009369
has subject term: D006801
has subject term: D016559Q000009
source: Hepatology. 2021-11;74(5):2912-2913.
volume: 74

[Animal Experimental Study of the Role of Menthol and Cineole, Two Tobacco Additives, on Nicotine Dependence].
pmid: 34323045
abstract: To establish a nicotine intravenous self-administration rat model, and to examine, with this model, the effects of two flavoring additives, menthol and cineole, on nicotine dependence.Thirty male Sprague-Dawley (SD) rats were included in the study. After jugular venous catheterization was performed, fixed concentration of nicotine was administered in order to train the rats and establish the rat model of intravenous self-administration groups, receiving intraperitoneal injection of menthol, cineole, and dimethyl sulfoxide (DMSO), the vehicle that was used for the control group. The rats were tested with different fixed-ratio (FR) schedules, including FR1 schedule, in which the rat received one nicotine infusion for every active nose poke, FR2 schedule, in which the rat received one nicotine infusion for every two active nose pokes, and FR5 schedule, in which the rat received one nicotine infusion for every five active nose pokes. The number of active and inactive poke responses and the number of nicotine infusion were documented accordingly.After 10 days of training in nicotine self-administration, the 30 rats demonstrated significant increase in the number of active poke responses and the number of nicotine infusion, which were maintained at a stable and relatively high level. The number of active poke responses was significantly higher that of inactive poke responses ( P< 0.001). The rat model of intravenous nicotine self-administration was successfully established. In the testing phase, under the FR2 schedule, the menthol group showed a reduced number of active poke responses ( P=0.020). Under the FR5 schedule, the groups showed obvious interaction between time and the number of active poke responses ( P<0.011), with the menthol group showing reduced number of active poke responses on day three ( P=0.011) and the cineole group showing rising number of active poke responses on day three ( P=0.003). The DMSO control group did not show any significant change.Menthol[cell cut: 2216 characters, first 2000 kept]
rights: Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).
doi: 10.12182/20210760202
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: He T
      type: Person
      first name: Tao
      last name: He
      member of: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  slot:
    index: 2
    item: Ma KY
      type: Person
      first name: Kuo-Yan
      last name: Ma
      member of: Chongqing Municipal Key Laboratory of Scientific Utilization of Tobacco Resources, Chongqing 400060, China.
  slot:
    index: 3
    item: Lü XL
      type: Person
      first name: Xiao-Li
      last name: Lü
      member of: Department of Psychiatry, Suzhou Psychiatric Hospital, Suzhou 215137, China.
  slot:
    index: 4
    item: Du XD
      type: Person
      first name: Xiang-Dong
      last name: Du
      member of: Department of Psychiatry, Suzhou Psychiatric Hospital, Suzhou 215137, China.
  slot:
    index: 5
    item: Hu AR
      type: Person
      first name: An-Ran
      last name: Hu
      member of: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  slot:
    index: 6
    item: Yao X
      type: Person
      first name: Xia
      last name: Yao
      member of: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  slot:
    index: 7
    item: Deng W
      type: Person
      first name: Wei
      last name: Deng
      member of: Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
created: 2021-7-30T06:00
date last updated: 2025-01-17
issued: 2021-07
dp: 2021 Jul
created: 2021-7-29T07:14
ISSN: 1672-173X
has issn l: 1672-173X
issue: 4
has NLM journal title abbreviation: Sichuan Da Xue Xue Bao Yi Xue Ban
publication name: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
language: chi
has national library of medicine journal id: 101162609
derived from: NLM
starting page: 649
ending page: 654
has place of publication: China
has primary subject term: D008610
has primary subject term: D014029
has subject term: D000818
has subject term: D008297
has subject term: D051381
has subject term: D003216
has subject term: http://id.nlm.nih.gov/mesh/D000077591
has subject term: D017207
has subject term: D012054
has subject term: D009538Q000008
source: Sichuan Da Xue Xue Bao Yi Xue Ban. 2021-07;52(4):649-654.
volume: 52

3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma.
pmid: 34491734
abstract: Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV-vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.
doi: 10.1021/acs.bioconjchem.1c00367
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Cai B
      type: Person
      first name: Bianyun
      last name: Cai
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.College of Medical Technology and Engineering, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang 471023, China.
  slot:
    index: 2
    item: Huang L
      type: Person
      first name: Leizhen
      last name: Huang
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 3
    item: Wang J
      type: Person
      first name: Jingcheng
      last name: Wang
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 4
    item: Sun D
      type: Person
      first name: Dan
      last name: Sun
      member of: Advanced Composite Research Group (ACRG), School of Mechanical and Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, United Kingdom.
  slot:
    index: 5
    item: Zhu C
      type: Person
      first name: Ce
      last name: Zhu
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 6
    item: Huang Y
      type: Person
      first name: Yong
      last name: Huang
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 7
    item: Li S
      type: Person
      first name: Shujun
      last name: Li
      member of: Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China.
  slot:
    index: 8
    item: Guo Z
      type: Person
      first name: Zhijun
      last name: Guo
      member of: School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China.
  slot:
    index: 9
    item: Liu L
      type: Person
      first name: Limin
      last name: Liu
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 10
    item: Feng G
      type: Person
      first name: Ganjun
      last name: Feng
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 11
    item: Li Y
      type: Person
      first name: Yubao
      last name: Li
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
  slot:
    index: 12
    item: Zhang L
      type: Person
      first name: Li
      last name: Zhang
      member of: Analytical & Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610065, China.
created: 2021-9-8T06:00
date last updated: 2025-01-17
issued: 2021-10-20
dp: 2021 Oct 20
created: 2021-9-7T17:12
e ISSN: 1520-4812
has issn l: 1043-1802
issue: 10
has NLM journal title abbreviation: Bioconjug Chem
publication name: Bioconjugate chemistry
language: eng
has national library of medicine journal id: 9010319
derived from: NLM
starting page: 2184
ending page: 2194
has place of publication: United States
has primary subject term: D014025Q000737
has primary subject term: D012516Q000473Q000188
has primary subject term: D066330
has primary subject term: D000497Q000737
has primary subject term: D054457Q000737
has primary subject term: D001859Q000473Q000188
has subject term: D006801
has subject term: D000818
has subject term: D045744
has subject term: D017886Q000737
source: Bioconjug Chem. 2021-10-20;32(10):2184-2194.
volume: 32

Evidence on article 5.3 of FCTC (tobacco industry interference in tobacco control activities) in India- a qualitative scoping study.
pmid: 34649546
abstract: The Tobacco Industry (henceforth TI) yearns to portray itself as being socially responsible and fights for the decision-making positions; that are it used to deter, delay or dilute tobacco control measures. There is little documented evidence of Tobacco Industry Interference (henceforth TII) from India, the scope of their interference and challenges faced by the experts for effective tobacco control. This research study seeks to cover this significant gap in the literature on the TI of India.A cross-sectional qualitative research design, based upon in-depth interviews (N = 26), was used to explore the key stakeholders' opinions regarding TII in India. The interviews used a set of questions to collect information about the participant's roles and responsibilities in tobacco control, the nature of TII faced by the participants, means of influence by TI, barriers and challenges to tobacco control efforts.Most of the respondents were engaged in tobacco control, training, advocacy and awareness generation activities for 5-10 years or more. The respondents defined the TI and its scope as per their experience with the help of the power ranking methodology. Most of them perceived TI as 'manufacturers' while others consider them as 'advertisers', 'public relation companies', 'wholesalers', 'vendors', and 'Government firms with TI stocks. The research team identified six significant domains: influencing the policy and administrative decisions, Interference in the implementation of tobacco control laws and activities, false propaganda and hiding the truth, manipulating front action groups (FAG), rampant tobacco advertising and promotion activities and others under which TII activities were classified. Most respondents believed that TI players were interfering in the policy decisions, implementing the tobacco control laws and activities and manipulating the FAG. A detailed taxonomic classification of the TII strategies that emerged from our analysis was linked to article 5.3 of[cell cut: 2511 characters, first 2000 kept]
rights: © 2021. The Author(s).
has PII: 10.1186/s12889-021-11773-x
doi: 10.1186/s12889-021-11773-x
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Goel S
      type: Person
      first name: Sonu
      last name: Goel
      member of: Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. sonugoel007@yahoo.co.in.Public Health Masters Program at School of Medicine, University of Limerick, Limerick, Ireland. sonugoel007@yahoo.co.in.Faculty of Human and Health Sciences, Swansea University, Swansea, United Kingdom. sonugoel007@yahoo.co.in.
  slot:
    index: 2
    item: Kar SS
      type: Person
      first name: Sitanshu Sekhar
      last name: Kar
      member of: Department of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Institute of Medical Education & Research, Puducherry, India.
  slot:
    index: 3
    item: Verma M
      type: Person
      first name: Madhur
      last name: Verma
      member of: Department of Community and Family Medicine, All India Institute of Medical Sciences Bathinda, Bathinda, Punjab, India.
  slot:
    index: 4
    item: Sivanantham P
      type: Person
      first name: Parthibane
      last name: Sivanantham
      member of: Department of Preventive & Social Medicine, Jawaharlal Institute of Postgraduate Institute of Medical Education & Research, Puducherry, India.
  slot:
    index: 5
    item: Naik BN
      type: Person
      first name: Bijay Nanda
      last name: Naik
      member of: Community & Family Medicine, All India Institute of Medical Sciences Patna, Patna, India.
  slot:
    index: 6
    item: Gupta D
      type: Person
      first name: Deepti
      last name: Gupta
      member of: Department of English and Cultural Studies, Panjab University, Chandigarh, India.
created: 2021-10-16T06:00
date last updated: 2025-01-17
issued: 2021-10-14
dp: 2021 10 14
created: 2021-10-15T05:27
e ISSN: 1471-2458
has issn l: 1471-2458
issue: 1
has NLM journal title abbreviation: BMC Public Health
publication name: BMC public health
language: eng
has national library of medicine journal id: 100968562
derived from: NLM
pg: 1855
has place of publication: England
has primary subject term: D019460
has subject term: D003430
has subject term: D006801
has subject term: D036301
has subject term: http://id.nlm.nih.gov/mesh/D000074606
source: BMC Public Health. 2021-10-14;21(1):1855.
volume: 21

Identifying suitable tester for evaluating Striga resistant lines using DArTseq markers and agronomic traits.
pmid: 34143833
abstract: A desirable tester that elicits greater genetic difference in Striga resistance among test crosses in a breeding program has not been reported. Therefore, this study was conducted to characterize 30 Striga resistant yellow endosperm maize inbred lines and three testers with varying resistance levels to Striga using DArTseq SNP markers and agronomic traits to identify a suitable tester for resistance hybrid breeding. Marker-based and agronomic trait-based genetic distances were estimated for yellow endosperm maize inbred lines and testers with varying resistance levels to Striga. The Marker-based cluster analysis separated the Striga resistant lines and testers into two distinct groups. Although the susceptible tester (T3) was the most distantly related to the 30 Striga resistant inbred lines, it exhibited a narrower range in genetic distance estimates and poor agronomic performance under Striga infestation in crosses with the resistant lines. In contrast, the resistant tester (T2) showed a broader range in genetic distance estimates in pairs with the 30 resistant lines. Also, it formed many high yielding hybrids with desirable traits under parasite pressure. Furthermore, the most significant positive association between agronomic trait-based and marker-based distance estimates (r = 0.389, P = 0.01) was observed when T2 has paired with the Striga resistant maize inbred lines. It thus appears that T2 may be used as a suitable tester to determine the breeding value of lines in hybrid maize resistance breeding programs. T2 was the most suitable tester, with a tolerant tester (T1) as an alternative tester to characterize the combining ability of Striga resistant maize inbred lines. This result can also encourage other breeders to investigate testers relative discriminating ability with varying levels of resistance in hybrid breeding for resistance to diseases, pests, and other parasitic plants.
has PII: PONE-D-20-38978
doi: 10.1371/journal.pone.0253481
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zebire D
      type: Person
      first name: Degife
      last name: Zebire
      member of: International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria.Pan Africa University of Life and Earth Sciences Institute, University of Ibadan, Ibadan, Nigeria.Department of Plant Science, College of Agricultural Sciences, Arba Minch University, Arba Minch, Ethiopia.
  slot:
    index: 2
    item: Menkir A
      type: Person
      first name: Abebe
      last name: Menkir
      member of: International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria.
  slot:
    index: 3
    item: Adetimirin V
      type: Person
      first name: Victor
      last name: Adetimirin
      member of: Department of Agronomy, University of Ibadan, Ibadan, Nigeria.
  slot:
    index: 4
    item: Mengesha W
      type: Person
      first name: Wende
      last name: Mengesha
      member of: International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria.
  slot:
    index: 5
    item: Meseka S
      type: Person
      first name: Silvestro
      last name: Meseka
      member of: International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria.
  slot:
    index: 6
    item: Gedil M
      type: Person
      first name: Melaku
      last name: Gedil
      member of: International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria.
created: 2021-6-19T06:00
date last updated: 2025-01-17
issued: 2021
dp: 2021
created: 2021-6-18T17:20
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 6
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0253481
has place of publication: United States
has primary subject term: D060467Q000235
has primary subject term: D010935Q000235
has primary subject term: D034362
has primary subject term: D003313Q000235
has subject term: D014644
has subject term: D010641
source: PLoS One. 2021;16(6):e0253481.
volume: 16

Light-induced synthesis of unsymmetrical organic carbonates from alcohols, methanol and CO2 under ambient conditions.
pmid: 34783333
abstract: The present work describes the first visible light-assisted, metal-free and organic base 1,1,3,3-tetramethyl guanidine (TMG) mediated synthesis of unsymmetrical methyl aryl/alkyl carbonates from the reaction of alcohols, methanol, and CO2 in high to excellent yields under atmospheric pressure and ambient temperature conditions.
doi: 10.1039/d1cc05833a
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Saini S
      type: Person
      first name: Sandhya
      last name: Saini
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.Academy of Scientific and Innovative Research, Ghaziabad-201002, India.
  slot:
    index: 2
    item: Gour NK
      type: Person
      first name: Nand Kishor
      last name: Gour
      member of: Department of Chemical Sciences, Tezpur University, Napaam, Tezpur-784028, Assam, India.
  slot:
    index: 3
    item: Khan SR
      type: Person
      first name: Shafiur Rehman
      last name: Khan
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 4
    item: Deka RC
      type: Person
      first name: Ramesh Chandra
      last name: Deka
      member of: Department of Chemical Sciences, Tezpur University, Napaam, Tezpur-784028, Assam, India.
  slot:
    index: 5
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
created: 2021-11-17T06:00
date last updated: 2025-01-17
issued: 2021-11-30
dp: 2021 Nov 30
created: 2021-11-16T09:09
e ISSN: 1364-548X
has issn l: 1359-7345
issue: 95
has NLM journal title abbreviation: Chem Commun (Camb)
publication name: Chemical communications (Cambridge, England)
language: eng
has national library of medicine journal id: 9610838
derived from: NLM
starting page: 12800
ending page: 12803
has place of publication: England
source: Chem Commun (Camb). 2021-11-30;57(95):12800-12803.
volume: 57

Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer.
pmid: 34590499
abstract: Treatment for advanced gastric cancer is challenging. Epidermal growth factor receptor (EGFR) contributes to the proliferation and development of gastric cancer (GC), and its overexpression is associated with unfavorable prognosis in GC. Cetuximab, a monoclonal antibody targeting EGFR, failed to improve the overall survival of gastric cancer patients indicated in phase III randomized trials. Glutamine is a vital nutrient for tumor growth and its metabolism contributes to therapeutic resistance, making glutamine uptake an attractive target for cancer treatment. The aim of the present study was to investigate whether intervention of glutamine uptake could improve the effect of cetuximab on GC. The results of MTT assay showed that by glutamine deprivation or inhibition of glutamine uptake, the viability of gastric carcinoma cells was inhibited more severely than that of human immortal gastric mucosa epithelial cells (GES-1). The expression of the key glutamine transporter alanine-serine-cysteine (ASC) transporter 2 (ASCT2; SLC1A5) was significantly higher in gastric carcinoma tissues and various gastric carcinoma cell lines than in normal gastric tissues and cells, as shown by immunohistochemistry and western blotting, while silencing ASCT2 significantly inhibited the viability and proliferation of gastric carcinoma cells. Consistent with previous studies, it was shown herein by MTT and EdU assays that cetuximab had a weak inhibitory effect on the cell viability of gastric carcinoma cells. However, inhibiting glutamine uptake by blockade of ASCT2 with l-γ-glutamyl-p-nitroanilide (GPNA) significantly enhanced the inhibitory effect of cetuximab on suppressing the proliferation of gastric cancer both in vitro and in vivo. Moreover, combining cetuximab and GPNA induced cell apoptosis considerably in gastric carcinoma cells, as shown by flow cytometry, and had a higher depressing effect on gastric cancer proliferation both in vitro and in vivo, as compared to either treatme[cell cut: 2180 characters, first 2000 kept]
doi: 10.1177/15347354211045349
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Ma H
      type: Person
      first name: Huanrong
      last name: Ma
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 2
    item: Wu J
      type: Person
      first name: Jingjing
      last name: Wu
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 3
    item: Zhou M
      type: Person
      first name: Minyu
      last name: Zhou
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 4
    item: Wu J
      type: Person
      first name: Jianhua
      last name: Wu
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 5
    item: Wu Z
      type: Person
      first name: Zhenzhen
      last name: Wu
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 6
    item: Lin L
      type: Person
      first name: Li
      last name: Lin
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 7
    item: Huang N
      type: Person
      first name: Na
      last name: Huang
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 8
    item: Liao W
      type: Person
      first name: Wangjun
      last name: Liao
      member of: Southern Medical University, Guangzhou, P.R. China.
  slot:
    index: 9
    item: Sun L
      type: Person
      first name: Li
      last name: Sun
      member of: Southern Medical University, Guangzhou, P.R. China.
created: 2021-10-1T06:00
date last updated: 2025-01-17
created: 2021-9-30T08:39
e ISSN: 1552-695X
has issn l: 1534-7354
has NLM journal title abbreviation: Integr Cancer Ther
publication name: Integrative cancer therapies
language: eng
has national library of medicine journal id: 101128834
derived from: NLM
pg: 15347354211045349
has place of publication: United States
has primary subject term: D005973
has primary subject term: D013274Q000188
has subject term: D026962
has subject term: D045744
has subject term: D049109
has subject term: D000068818Q000494
has subject term: D006801
has subject term: D015778
source: Integr Cancer Ther. ;20():15347354211045349.
volume: 20

The Origins and Purposes of Alcohol Industry Social Aspects Organizations: Insights From the Tobacco Industry Documents.
pmid: 34762033
abstract: This article describes the origins and purposes of alcohol industry social aspects organizations as portrayed in internal tobacco industry documents.We systematically searched the Truth Tobacco Documents Library for information regarding alcohol industry social aspects organizations. Using content provided by industry actors themselves, we identified a series of episodes in their evolution from the early 1950s to the early 1990s.Hill and Knowlton, a public relations company, developed and managed the tobacco industry's scientific programs from the early 1950s onward. At the same time, the company performed a similar function for the U.S. distilled spirits industry, with research funding central to advancing what were conceived as public relations goals. They sought to persuade the public and policy makers that the cause of alcohol problems was the people who drank distilled spirits, rather than the product itself. Facing the existential threat posed by the developing population-level understanding of alcohol problems in the 1980s, national and international trade associations collaborated with the tobacco industry in various ways. The largest companies sought to bring together the different sectors of the alcohol industry to support a global network of national-level social aspects organizations.Alcohol industry social aspects organizations were developed to advance long-term public relations goals to manage both policy and science.
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: McCambridge J
      type: Person
      first name: Jim
      last name: McCambridge
      member of: Department of Health Sciences, University of York, York, United Kingdom.
  slot:
    index: 2
    item: Garry J
      type: Person
      first name: Jack
      last name: Garry
      member of: Department of Health Sciences, University of York, York, United Kingdom.
  slot:
    index: 3
    item: Room R
      type: Person
      first name: Robin
      last name: Room
      member of: La Trobe University, Melbourne, Australia.Centre for Social Research on Alcohol and Drugs, Department of Public Health Sciences, Stockholm University, Stockholm, Sweden.
created: 2021-11-12T06:00
date last updated: 2025-01-17
issued: 2021-11
dp: 2021 11
created: 2021-11-11T12:17
e ISSN: 1938-4114
has issn l: 1937-1888
issue: 6
has NLM journal title abbreviation: J Stud Alcohol Drugs
publication name: Journal of studies on alcohol and drugs
language: eng
has national library of medicine journal id: 101295847
derived from: NLM
starting page: 740
ending page: 751
has place of publication: United States
has primary subject term: D019460
has subject term: D000434
has subject term: D003132
has subject term: D006801
has subject term: D038622
source: J Stud Alcohol Drugs. 2021-11;82(6):740-751.
volume: 82

Involvement of m6A regulatory factor IGF2BP1 in malignant transformation of human bronchial epithelial Beas-2B cells induced by tobacco carcinogen NNK.
pmid: 34974052
abstract: Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a Group 1 human carcinogen, as classified by the International Agency for Research of Cancer (IARC), and plays a significant role in lung carcinogenesis. However, its carcinogenic mechanism has not yet been fully elucidated. In this study, we performed colony formation assays, soft-agar assays, and tumor growth in nude mice to show that 100 mg/L NNK facilitates the malignant transformation of human bronchial epithelial Beas-2B cells. Transcriptome sequencing showed that insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a post-transcriptional regulator, was differentially expressed in NNK-induced malignant transformed Beas-2B cells (2B-NNK cells). Small interfering RNA (SiRNA) was used to downregulate the expression of the IGF2BP1 gene. The reduction in protein expression, cell proliferation rate, and colony-forming ability and the increase in the apoptosis rate of Beas-2B cells transfected with the SiRNA indicated a role for IGF2BP1 in NNK-induced malignant transformation. IGF2BP1 is an N6-methyladenosine (m6A) regulatory factor, but it is not known whether its association with m6A mediates the malignant transformation of cells. Therefore, we measured the overall levels of m6A in Beas-2B cells. We found that the overall m6A level was lower in 2B-NNK cells, and knocking down IGF2BP1, the overall level of m6A was restored. Hence, we concluded that IGF2BP1 is involved in the NNK-induced malignant transformation of Beas-2B cells, possibly via m6A modification. This study therefore contributes novel insights into the environmental pathogenesis of lung cancer and the gene regulatory mechanisms of chemical carcinogenesis.
rights: Copyright © 2021 Elsevier Inc. All rights reserved.
has PII: S0041-008X(21)00453-1
doi: 10.1016/j.taap.2021.115849
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zhou J
      type: Person
      first name: Jiaxin
      last name: Zhou
      member of: The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.
  slot:
    index: 2
    item: Xiong R
      type: Person
      first name: Rui
      last name: Xiong
      member of: The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.
  slot:
    index: 3
    item: Zhou J
      type: Person
      first name: Jiazhen
      last name: Zhou
      member of: The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.
  slot:
    index: 4
    item: Guan X
      type: Person
      first name: Xinchao
      last name: Guan
      member of: The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.
  slot:
    index: 5
    item: Jiang G
      type: Person
      first name: Guanqing
      last name: Jiang
      member of: The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.
  slot:
    index: 6
    item: Chen Y
      type: Person
      first name: Yuyang
      last name: Chen
      member of: School of Anesthesiology, Southern Medical University, 1023-1063 Shatai Nan Road, Baiyun District, Guangzhou 510515, China.
  slot:
    index: 7
    item: Yang Q
      type: Person
      first name: Qiaoyuan
      last name: Yang
      member of: The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, No. 151 Yanjiang Road, Yuexiu District, Guangzhou 510120, China. Electronic address: qiaoyuan_yang@gzhmu.edu.cn.
created: 2022-1-3T06:00
date last updated: 2025-01-17
issued: 2022-02-01
dp: 2022 02 01
created: 2022-1-2T20:21
e ISSN: 1096-0333
has issn l: 0041-008X
has NLM journal title abbreviation: Toxicol Appl Pharmacol
publication name: Toxicology and applied pharmacology
language: eng
has national library of medicine journal id: 0416575
derived from: NLM
pg: 115849
has place of publication: United States
has primary subject term: D001980Q000187
has primary subject term: D002074Q000494
has primary subject term: D002471Q000139Q000235
has primary subject term: D004847Q000187
has primary subject term: D008780Q000378
has primary subject term: D009602Q000494
has primary subject term: D016601Q000235
has subject term: D000328
has subject term: D000368
has subject term: D000818
has subject term: D017209Q000187Q000235
has subject term: D002273Q000494
has subject term: D002460
has subject term: D049109Q000187Q000235
has subject term: D015536Q000502
has subject term: D005786Q000187Q000235
has subject term: D006801
has subject term: D008168Q000187
has subject term: D008175Q000139Q000235
has subject term: D008297
has subject term: D051379
has subject term: D008807
has subject term: D008819
has subject term: D008875
has subject term: D014162Q000379
source: Toxicol Appl Pharmacol. 2022-02-01;436():115849.
volume: 436

Beware big tobacco bearing gifts: tobacco industry corporate social responsibility activities in Greece.
pmid: 35078912
has PII: tobaccocontrol-2021-057143
doi: 10.1136/tobaccocontrol-2021-057143
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Taravira NA
      type: Person
      first name: Nefeli A
      last name: Taravira
      member of: Department of Primary Care and Public Health, Imperial College London, London, UK.
  slot:
    index: 2
    item: Laurence L
      type: Person
      first name: Louis
      last name: Laurence
      member of: Department for Health, University of Bath, Bath, UK.
  slot:
    index: 3
    item: Filippidis FT
      type: Person
      first name: Filippos T
      last name: Filippidis
      member of: Department of Primary Care and Public Health, Imperial College London, London, UK f.filippidis@imperial.ac.uk.
created: 2022-1-27T06:00
date last updated: 2025-01-17
issued: 2023-09
dp: 2023 09
created: 2022-1-26T05:28
e ISSN: 1468-3318
has issn l: 0964-4563
issue: 5
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 675
ending page: 676
has place of publication: England
has primary subject term: D019460
has subject term: D006801
has subject term: D006115
has subject term: D037921
has subject term: D012941
source: Tob Control. 2023-09;32(5):675-676.
volume: 32

Physical exertion at work and addictive behaviors: tobacco, cannabis, alcohol, sugar and fat consumption: longitudinal analyses in the CONSTANCES cohort.
pmid: 35027592
abstract: We examined the prospective association of physical exertion at work with subsequent tobacco, cannabis, alcohol use, and sugar and fat consumption. Volunteers of the French population-based CONSTANCES cohort currently employed were included from 2012 to 2017 for tobacco and cannabis outcomes (n = 100,612), and from 2012 to 2016 for alcohol and sugar and fat outcomes (n = 75,414). High level of physical exertion at work was defined as a score ≥ 12 at the Rating Perceived Exertion Borg scale. Substance use was self-reported and diet rich in sugar and fat was obtained from principal component analysis and analyzed as quartiles. Generalized linear models computed odds of substance use and sugar and fat consumption at follow-up according to baseline physical exertion at work, while adjusting for sociodemographic factors, depressive symptoms and baseline level of consumption. High physical exertion was associated with tobacco use with dose-dependent relationships. It was also associated with increased odds of cannabis use at least once per month compared to no use in the past and with increased odds of diet rich in sugar and fat. Hence, the role of physical exertion at work on tobacco and cannabis use and diet rich in sugar and fat should be tackled for information and prevention strategies.
rights: © 2022. The Author(s).
has PII: 10.1038/s41598-021-04475-2
doi: 10.1038/s41598-021-04475-2
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Hamieh N
      type: Person
      first name: Nadine
      last name: Hamieh
      member of: INSERM, Population-Based Epidemiological Cohorts Unit, UMS 011, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif, France. nadine.hamieh@inserm.fr.
  slot:
    index: 2
    item: Descatha A
      type: Person
      first name: Alexis
      last name: Descatha
      member of: Poison Control Center, Academic Hospital CHU Angers, F-49000, Angers, France.Univ Angers, Centre Hospitalier Universitaire CHU Angers, Université de Rennes, INSERM, École des hautes études en santé publique, Institut de recherche en santé, environnement et travail Irset UMR_S 1085, F-49000, Angers, France.
  slot:
    index: 3
    item: Zins M
      type: Person
      first name: Marie
      last name: Zins
      member of: INSERM, Population-Based Epidemiological Cohorts Unit, UMS 011, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif, France.Université de Paris, Faculty of Health, School of Medicine, Paris, France.
  slot:
    index: 4
    item: Goldberg M
      type: Person
      first name: Marcel
      last name: Goldberg
      member of: INSERM, Population-Based Epidemiological Cohorts Unit, UMS 011, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif, France.Université de Paris, Faculty of Health, School of Medicine, Paris, France.
  slot:
    index: 5
    item: Czernichow S
      type: Person
      first name: Sébastien
      last name: Czernichow
      member of: Université de Paris, AP-HP, Hôpital européen Georges-Pompidou, Service de Nutrition, Paris, France.
  slot:
    index: 6
    item: Hoertel N
      type: Person
      first name: Nicolas
      last name: Hoertel
      member of: Université de Paris, AP-HP, Hôpital Corentin-Celton, DMU Psychiatrie et Addictologie, Service de psychiatrie et d'addictologie de l'adulte et du sujet âgé, Issy-les-Moulineaux, INSERM, Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, Paris, France.
  slot:
    index: 7
    item: Plessz M
      type: Person
      first name: Marie
      last name: Plessz
      member of: INRAE, Centre Maurice Halbwachs (ENS, EHESS, CNRS) UMR 8097, Paris, France.
  slot:
    index: 8
    item: Roquelaure Y
      type: Person
      first name: Yves
      last name: Roquelaure
      member of: Poison Control Center, Academic Hospital CHU Angers, F-49000, Angers, France.University of Angers, Centre Hospitalier Universitaire d'Angers, Université de Rennes, Centre de consultations de pathologie professionnelle et santé au travail, F-49000, Angers, France.
  slot:
    index: 9
    item: Limosin F
      type: Person
      first name: Frédéric
      last name: Limosin
      member of: Université de Paris, AP-HP, Hôpital Corentin-Celton, DMU Psychiatrie et Addictologie, Service de psychiatrie et d'addictologie de l'adulte et du sujet âgé, Issy-les-Moulineaux, INSERM, Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, Paris, France.
  slot:
    index: 10
    item: Lemogne C
      type: Person
      first name: Cédric
      last name: Lemogne
      member of: Université de Paris, AP-HP, Hôpital Hôtel-Dieu, DMU Psychiatrie et Addictologie, Service de Psychiatrie de l'adulte, INSERM, Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, Paris, France.
  slot:
    index: 11
    item: Matta J
      type: Person
      first name: Joane
      last name: Matta
      member of: INSERM, Population-Based Epidemiological Cohorts Unit, UMS 011, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif, France.
  slot:
    index: 12
    item: Airagnes G
      type: Person
      first name: Guillaume
      last name: Airagnes
      member of: INSERM, Population-Based Epidemiological Cohorts Unit, UMS 011, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif, France.Université de Paris, Faculty of Health, School of Medicine, Paris, France.Université de Paris, AP-HP.Centre-Université de Paris, DMU Psychiatrie et Addictologie, Paris, France.
created: 2022-1-15T06:00
date last updated: 2025-01-17
issued: 2022-01-13
dp: 2022 01 13
created: 2022-1-14T05:51
e ISSN: 2045-2322
has issn l: 2045-2322
issue: 1
has NLM journal title abbreviation: Sci Rep
publication name: Scientific reports
language: eng
has national library of medicine journal id: 101563288
derived from: NLM
pg: 661
has place of publication: England
has primary subject term: D000434
has primary subject term: D016739Q000523
has primary subject term: D002188
has primary subject term: D004041
has primary subject term: D005247
has primary subject term: D016272
has primary subject term: D005082
has primary subject term: http://id.nlm.nih.gov/mesh/D000073893
has primary subject term: D014937Q000502Q000523
has subject term: D000293
has subject term: D000328
has subject term: D005260
has subject term: D005602
has subject term: D006801
has subject term: D008137
has subject term: D008297
has subject term: D008875
has subject term: D011446
has subject term: D055815
source: Sci Rep. 2022-01-13;12(1):661.
volume: 12

CO2 as oxidant: an unusual light-assisted catalyst free oxidation of aldehydes to acids under mild conditions.
pmid: 35072682
abstract: A novel visible light-driven catalyst-free oxidation of aldehydes using CO2 both in batch and flow photoreactors to get corresponding acids along with the formation of CO in the effluent gas is described.
doi: 10.1039/d1cc06057k
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Khan SR
      type: Person
      first name: Shafiur Rehman
      last name: Khan
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 2
    item: Saini S
      type: Person
      first name: Sandhya
      last name: Saini
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.Academy of Scientific and Innovative Research, Ghaziabad-201002, India.
  slot:
    index: 3
    item: Naresh K
      type: Person
      first name: K
      last name: Naresh
      member of: Process Engineering Technology Transfer Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
  slot:
    index: 4
    item: Kumari A
      type: Person
      first name: Alka
      last name: Kumari
      member of: Process Engineering Technology Transfer Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
  slot:
    index: 5
    item: Aniya V
      type: Person
      first name: Vineet
      last name: Aniya
      member of: Process Engineering Technology Transfer Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
  slot:
    index: 6
    item: Khatri PK
      type: Person
      first name: Praveen K
      last name: Khatri
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 7
    item: Ray A
      type: Person
      first name: Anjan
      last name: Ray
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.Director, CSIR-Indian Institute of Petroleum, Mohkampur, Dehradun-248004, India.
  slot:
    index: 8
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
      member of: Chemical & Material Sciences Division, CSIR-Indian Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
created: 2022-1-25T06:00
date last updated: 2025-01-17
issued: 2022-02-10
dp: 2022 Feb 10
created: 2022-1-24T12:13
e ISSN: 1364-548X
has issn l: 1359-7345
issue: 13
has NLM journal title abbreviation: Chem Commun (Camb)
publication name: Chemical communications (Cambridge, England)
language: eng
has national library of medicine journal id: 9610838
derived from: NLM
starting page: 2208
ending page: 2211
has place of publication: England
source: Chem Commun (Camb). 2022-02-10;58(13):2208-2211.
volume: 58

http://rdf.ncbi.nlm.nih.gov/pubmed/35942972
pmid: 35942972
abstract: Lacy-Nichols and Williams' examination of the food industry illustrates how it altered its approach from mostly oppositional to regulation to one of appeasement and co-option. This reflection builds upon this by using a commercial determinants of health (CDoH) lens to understand, expose and counter industry co-option, appeasement and partnership strategies that impact public health. Lessons learned from tobacco reveal how tobacco companies maintained public credibility by recruiting scientists to produce industry biased data, co-opting public health groups, gaining access to policy elites and sitting on important government regulatory bodies. Potential counter solutions to food industry appeasement and co-option include (i) understanding corporate actions of health harming industries, (ii) applying mechanisms to minimize industry engagement, (iii) dissecting industry relationship building, and (iv) exposing the negative effects of public private partnerships (PPPs). Such counter-solutions might help to neutralise harmful industry practices, products and policies which currently threaten to undermine healthy food policies.
rights: © 2022 The Author(s); Published by Kerman University of Medical Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
doi: 10.34172/ijhpm.2022.7371
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Crosbie E
      type: Person
      first name: Eric
      last name: Crosbie
      member of: School of Public Health, University of Nevada Reno, Reno, NV, USA.Ozmen Institute for Global Studies, University of Nevada Reno, Reno, NV, USA.
  slot:
    index: 2
    item: Carriedo A
      type: Person
      first name: Angela
      last name: Carriedo
      member of: World Public Health Nutrition Association, London, UK.Department of Health, University of Bath, Bath, UK.
created: 2022-8-10T06:00
date last updated: 2025-01-17
issued: 2022-12-06
dp: 2022 12 06
created: 2022-8-9T05:59
e ISSN: 2322-5939
has issn l: 2322-5939
issue: 11
has NLM journal title abbreviation: Int J Health Policy Manag
publication name: International journal of health policy and management
language: eng
has national library of medicine journal id: 101619905
derived from: NLM
starting page: 2744
ending page: 2747
has place of publication: Iran
has primary subject term: D009938
has primary subject term: D019460
has subject term: D006801
has subject term: D055818
has subject term: D019649
has subject term: D011634
source: Int J Health Policy Manag. 2022-12-06;11(11):2744-2747.
title: Applying a Commercial Determinants of Health Lens to Understand, Expose and Counter Industry Co-option, Appeasement and Partnership Comment on 'Part of the Solution': Food Corporation Strategies for Regulatory Capture and Legitimacy .
volume: 11

Framing the policy debate over tobacco control legislation and tobacco taxation in South Africa.
pmid: 34824147
abstract: In 2018, South Africa opened public consultations on its newly proposed tobacco control bill, resulting in substantial public debate in which a range of arguments, either in favour of or against the Bill, was advanced. These were accompanied by the recurring discussions about the annual adjustments in tobacco taxation. This study uses the concept of framing to examine the public debate in South African print media on the potential effects of the legislation, as well as tobacco tax regulations, between their proponents and detractors.A systematic search of news articles using multiple data sources identified 132 media articles published between January 2018 and September 2019 that met the inclusion criteria.Seven overarching frames were identified as characterising the media debate, with the three dominant frames being Economic, Harm reduction and vaping, and Health. The leading Economic frame consisted primarily of arguments unsupportive of tobacco control legislation. Economic arguments were promoted by tobacco industry spokespeople, trade unions, organisations of retailers, media celebrities and think tanks-several of which have been identified as front groups or third-party lobbyists for the tobacco industry.The dominance of economic arguments opposing tobacco control legislation risks undermining tobacco control progress. Local and global tobacco control advocates should seek to build relationships with media, as well as collate and disseminate effective counterarguments to those advanced by the industry.
rights: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: tobaccocontrol-2021-056675
doi: 10.1136/tobaccocontrol-2021-056675
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zatoński MZ
      type: Person
      first name: Mateusz Zygmunt
      last name: Zatoński
      member of: Department for Health, University of Bath, Bath, UK zatonski.mateusz@gmail.com.European Observatory of Health Inequalities, Calisia University, Kalisz, Poland.
  slot:
    index: 2
    item: Egbe CO
      type: Person
      first name: Catherine O
      last name: Egbe
      member of: Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Pretoria, Gauteng, South Africa.Department of Public Health, Sefako Makgatho Health Sciences University, Pretoria, Gauteng, South Africa.
  slot:
    index: 3
    item: Robertson L
      type: Person
      first name: Lindsay
      last name: Robertson
      member of: Department for Health, University of Bath, Bath, UK.Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.
  slot:
    index: 4
    item: Gilmore A
      type: Person
      first name: Anna
      last name: Gilmore
      member of: Department for Health, University of Bath, Bath, UK.
created: 2021-11-27T06:00
date last updated: 2025-01-17
issued: 2023-07
dp: 2023 07
created: 2021-11-26T06:03
e ISSN: 1468-3318
has issn l: 0964-4563
issue: 4
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 450
ending page: 457
has place of publication: England
has primary subject term: D019460
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000092843
has subject term: D013019
has subject term: D006291
has subject term: D013660
source: Tob Control. 2023-07;32(4):450-457.
volume: 32

Could international human rights obligations motivate countries to implement tobacco cessation support?
pmid: 35792059
abstract: The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) seeks to realize the right to health through national tobacco control policies. However, few states have met their obligations under Article 14 of the FCTC to develop evidence-based policies to support tobacco cessation. This article examines how human rights obligations could provide a legal and moral basis for states to implement greater support for individuals to overcome their addiction to tobacco.The United Nations (UN) has a well-established legal framework for promoting human rights, looking to the right to health to realize health autonomy. Where addiction undermines autonomy, it is widely acknowledged that addiction presents a significant barrier to cessation for individuals who use tobacco, undermining the right to health. The UN human rights system could, therefore, provide a complementary basis for monitoring state obligations under Article 14 of the FCTC, identifying challenges to FCTC implementation and motivating states to support tobacco cessation.The United Nations' human rights system offers a mechanism that could be used to monitor Framework Convention on Tobacco Control implementation in national policy, facilitating accountability for the progressive realization of cessation support.
rights: © 2022 Society for the Study of Addiction.
doi: 10.1111/add.15990
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Meier BM
      type: Person
      first name: Benjamin Mason
      last name: Meier
      member of: Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
  slot:
    index: 2
    item: Raw M
      type: Person
      first name: Martin
      last name: Raw
      member of: School of Global Public Health, New York University, New York, NY, USA.International Centre for Tobacco Cessation, UK.
  slot:
    index: 3
    item: Shelley D
      type: Person
      first name: Donna
      last name: Shelley
      member of: School of Global Public Health, New York University, New York, NY, USA.
  slot:
    index: 4
    item: Bostic C
      type: Person
      first name: Chris
      last name: Bostic
      member of: Action on Smoking and Health (ASH), Washington, DC, USA.
  slot:
    index: 5
    item: Gupta A
      type: Person
      first name: Anahita
      last name: Gupta
      member of: Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
  slot:
    index: 6
    item: Romeo-Stuppy K
      type: Person
      first name: Kelsey
      last name: Romeo-Stuppy
      member of: Action on Smoking and Health (ASH), Washington, DC, USA.
  slot:
    index: 7
    item: Huber L
      type: Person
      first name: Laurent
      last name: Huber
      member of: Action on Smoking and Health (ASH), Washington, DC, USA.
created: 2022-7-7T06:00
date last updated: 2025-01-17
issued: 2023-03
dp: 2023 03
created: 2022-7-6T06:33
e ISSN: 1360-0443
has issn l: 0965-2140
issue: 3
has NLM journal title abbreviation: Addiction
publication name: Addiction (Abingdon, England)
language: eng
has national library of medicine journal id: 9304118
derived from: NLM
starting page: 399
ending page: 406
has place of publication: England
has primary subject term: D020340
has primary subject term: D019460
has subject term: D006801
has subject term: D007391
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D014944
has subject term: D006806
source: Addiction. 2023-03;118(3):399-406.
volume: 118

Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure.
pmid: 35514311
abstract: For decades, the link between poor oral hygiene and the increased prevalence of oral cancer has been suggested. Most recently, emerging evidence has suggested that chronic inflammatory diseases from the oral cavity (e.g., periodontal disease), to some extent, play a role in the development of oral squamous cell carcinoma (OSCC). The present study aimed to explore the direct impact of biofilm‑induced periodontitis in the carcinogenesis process using a tobacco surrogate animal model for oral cancer. A total of 42 Wistar rats were distributed into four experimental groups: Control group, periodontitis (Perio) group, 4‑nitroquinoline 1‑oxide (4‑NQO) group and 4NQO/Perio group. Periodontitis was stimulated by placing a ligature subgingivally, while oral carcinogenesis was induced by systemic administration of 4NQO in the drinking water for 20 weeks. It was observed that the Perio, 4NQO and 4NQO/Perio groups presented with significantly higher alveolar bone loss compared with that in the control group. Furthermore, all groups receiving 4NQO developed lesions on the dorsal surface of the tongue; however, the 4NQO/Perio group presented larger lesions compared with the 4NQO group. There was also a modest overall increase in the number of epithelial dysplasia and OSCC lesions in the 4NQO/Perio group. Notably, abnormal focal activation of cellular differentiation (cytokeratin 10‑positive cells) that extended near the basal cell layer of the mucosa was observed in rats receiving 4NQO alone, but was absent in rats receiving 4NQO and presenting with periodontal disease. Altogether, the presence of periodontitis combined with 4NQO administration augmented tumor size in the current rat model and tampered with the protective mechanisms of the cellular differentiation of epithelial cells.
has PII: 77
doi: 10.3892/ijo.2022.5367
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Spuldaro TR
      type: Person
      first name: Tobias R
      last name: Spuldaro
      member of: Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, RS 90010‑150, Brazil.
  slot:
    index: 2
    item: Wagner VP
      type: Person
      first name: Vivian P
      last name: Wagner
      member of: Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, RS 90010‑150, Brazil.
  slot:
    index: 3
    item: Nör F
      type: Person
      first name: Felipe
      last name: Nör
      member of: Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, RS 90010‑150, Brazil.
  slot:
    index: 4
    item: Gaio EJ
      type: Person
      first name: Eduardo J
      last name: Gaio
      member of: Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, RS 90010‑150, Brazil.
  slot:
    index: 5
    item: Squarize CH
      type: Person
      first name: Cristiane H
      last name: Squarize
      member of: Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109‑1078, USA.
  slot:
    index: 6
    item: Carrard VC
      type: Person
      first name: Vinicius C
      last name: Carrard
      member of: Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, RS 90010‑150, Brazil.
  slot:
    index: 7
    item: Rösing CK
      type: Person
      first name: Cassiano K
      last name: Rösing
      member of: Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, RS 90010‑150, Brazil.
  slot:
    index: 8
    item: Castilho RM
      type: Person
      first name: Rogerio M
      last name: Castilho
      member of: Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109‑1078, USA.
created: 2022-5-7T06:00
date last updated: 2025-01-17
issued: 2022-06
dp: 2022 Jun
created: 2022-5-6T05:13
e ISSN: 1791-2423
has issn l: 1019-6439
issue: 6
has NLM journal title abbreviation: Int J Oncol
publication name: International journal of oncology
language: eng
has national library of medicine journal id: 9306042
derived from: NLM
has place of publication: Greece
has primary subject term: D002294Q000139Q000473
has primary subject term: D006258
has primary subject term: D009062Q000139Q000473
has primary subject term: D010510
has primary subject term: D010518
has subject term: D015112Q000633
has subject term: D000818
has subject term: D063646
has subject term: D004195
has subject term: D006801
has subject term: D051381
has subject term: D017208
has subject term: http://id.nlm.nih.gov/mesh/D000077195
source: Int J Oncol. 2022-06;60(6):.
volume: 60

Radon, Tobacco Exposure and Non-Small Cell Lung Cancer Risk Related to BER and NER Genetic Polymorphisms.
pmid: 35312585
abstract: Tobacco consumption and radon exposure are considered the first and second most common causes of lung cancer, respectively. The aim of this study was to analyze both whether selected genetic polymorphisms in loci that are in DNA repair pathways, are related to non-small-cell lung cancer (NSCLC) and whether they may modulate the association between residential radon exposure and lung cancer in both smokers and never smokers.A multicentre, hospital-based, case-control study with 826 cases and 1201 controls was designed in a radon-prone area. Genotyping was determined in whole blood and residential radon exposure was measured in participants' dwellings.Attending to tobacco exposure, the variant in the gene NBN (rs1805794) was associated with lung cancer in never smokers (OR 2.72; 95%1.44-5.2) and heavy smokers (OR 3.04; 95%CI 1.21-7.69). The polymorphism with the highest lung cancer association was OGG1 (rs125701), showing an OR of 8.04 (95%CI 1.64-58.29) for its homozygous variant genotype in heavy smokers. Attending to indoor radon exposure (>200Bq/m3), rs1452584, for its homozygous variant genotype, showed the highest association (OR 3.04 (95%CI 1.15-8.48).The genes analyzed seem to have no association with the fully adjusted model, but they might modulate lung cancer association when different categories of tobacco consumption are considered (i.e. heavy smokers). This association may similarly be elevated for those individuals having high indoor radon exposures, though at a minor extent.
rights: Copyright © 2021 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.
has PII: S0300-2896(21)00209-X
doi: 10.1016/j.arbres.2021.07.006
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Enjo-Barreiro JR
      type: Person
      first name: José Ramón
      last name: Enjo-Barreiro
      member of: Service of Preventive Medicine, University Complex of Santiago de Compostela, Spain; Department of Preventive Medicine, Santiago de Compostela University Teaching Hospital Complex, Santiago de Compostela, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública, CIBERESP), Spain.
  slot:
    index: 2
    item: Ruano-Ravina A
      type: Person
      first name: Alberto
      last name: Ruano-Ravina
      member of: Department of Preventive Medicine, Santiago de Compostela University Teaching Hospital Complex, Santiago de Compostela, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública, CIBERESP), Spain; Health Research Institute of Santiago de Compostela (Instituto de Investigación Sanitaria de Santiago de Compostela-IDIS), Santiago de Compostela, Spain. Electronic address: alberto.ruano@usc.es.
  slot:
    index: 3
    item: Pérez-Ríos M
      type: Person
      first name: Mónica
      last name: Pérez-Ríos
      member of: Department of Preventive Medicine, Santiago de Compostela University Teaching Hospital Complex, Santiago de Compostela, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública, CIBERESP), Spain; Health Research Institute of Santiago de Compostela (Instituto de Investigación Sanitaria de Santiago de Compostela-IDIS), Santiago de Compostela, Spain.
  slot:
    index: 4
    item: Kelsey K
      type: Person
      first name: Karl
      last name: Kelsey
      member of: Department of Epidemiology, Brown School of Public Health, Brown University, Providence, Rhode Island, USA.
  slot:
    index: 5
    item: Varela-Lema L
      type: Person
      first name: Leonor
      last name: Varela-Lema
      member of: Department of Preventive Medicine, Santiago de Compostela University Teaching Hospital Complex, Santiago de Compostela, Spain.
  slot:
    index: 6
    item: Torres-Durán M
      type: Person
      first name: María
      last name: Torres-Durán
      member of: Service of Neumology, University Hospital Complex of Vigo, Spain.
  slot:
    index: 7
    item: Parente-Lamelas I
      type: Person
      first name: Isaura
      last name: Parente-Lamelas
      member of: Service of Neumology, University Hospital Complex of Ourense, Spain.
  slot:
    index: 8
    item: Provencio-Pulla M
      type: Person
      first name: Mariano
      last name: Provencio-Pulla
      member of: Service of Medical Oncology, Puerta del Hierro University Hospital of Madrid, Spain.
  slot:
    index: 9
    item: Vidal-García I
      type: Person
      first name: Iria
      last name: Vidal-García
      member of: Service of Neumology, University Hospital Complex of A Coruña, Spain.
  slot:
    index: 10
    item: Piñeiro-Lamas M
      type: Person
      first name: María
      last name: Piñeiro-Lamas
      member of: Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública, CIBERESP), Spain.
  slot:
    index: 11
    item: Fernández-Villar JA
      type: Person
      first name: José A
      last name: Fernández-Villar
      member of: Service of Neumology, University Hospital Complex of Ourense, Spain.
  slot:
    index: 12
    item: Barros-Dios JM
      type: Person
      first name: Juan M
      last name: Barros-Dios
      member of: Service of Preventive Medicine, University Complex of Santiago de Compostela, Spain; Department of Preventive Medicine, Santiago de Compostela University Teaching Hospital Complex, Santiago de Compostela, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública, CIBERESP), Spain.
created: 2022-3-22T06:00
date last updated: 2025-01-17
issued: 2022-04
dp: 2022 Apr
created: 2022-3-21T17:17
e ISSN: 1579-2129
has issn l: 0300-2896
issue: 4
has NLM journal title abbreviation: Arch Bronconeumol
publication name: Archivos de bronconeumologia
language: engspa
has national library of medicine journal id: 0354720
derived from: NLM
starting page: 311
ending page: 322
has place of publication: Spain
has primary subject term: D016902Q000009
has primary subject term: D002289Q000209Q000235
has primary subject term: D008175Q000209Q000235
has primary subject term: D009381Q000209
has primary subject term: D011886Q000009
has subject term: D016022
has subject term: D006801
has subject term: D011110
has subject term: D012307
source: Arch Bronconeumol. 2022-04;58(4):311-322.
volume: 58

Cross-sectional study of urinary biomarkers of environmental tobacco and e-cigarette exposure and asthma morbidity.
pmid: 35688366
has PII: S1081-1206(22)00499-9
doi: 10.1016/j.anai.2022.06.001
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Ruran HB
      type: Person
      first name: Hana B
      last name: Ruran
      member of: Hopkinton High School, Hopkinton, Massachusetts; Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts.
  slot:
    index: 2
    item: Maciag MC
      type: Person
      first name: Michelle C
      last name: Maciag
      member of: Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
  slot:
    index: 3
    item: Murphy SE
      type: Person
      first name: Sharon E
      last name: Murphy
      member of: University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.
  slot:
    index: 4
    item: Phipatanakul W
      type: Person
      first name: Wanda
      last name: Phipatanakul
      member of: Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
  slot:
    index: 5
    item: Hauptman M
      type: Person
      first name: Marissa
      last name: Hauptman
      member of: Harvard Medical School, Boston, Massachusetts; Division of General Pediatrics, Pediatric Environmental Health Center, Boston Children's Hospital, Boston, Massachusetts; Region 1 New England Pediatric Environmental Health Specialty Unit, Boston, Massachusetts. Electronic address: Marissa.hauptman@childrens.harvard.edu.
created: 2022-6-11T06:00
date last updated: 2025-01-17
issued: 2022-09
dp: 2022 09
created: 2022-6-10T19:27
e ISSN: 1534-4436
has issn l: 1081-1206
issue: 3
has NLM journal title abbreviation: Ann Allergy Asthma Immunol
publication name: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
language: eng
has national library of medicine journal id: 9503580
derived from: NLM
starting page: 378
ending page: 380
has place of publication: United States
has primary subject term: D001249Q000453
has primary subject term: D066300
has subject term: D015415
has subject term: D003430
has subject term: D004781Q000009
has subject term: D006801
has subject term: D009017
source: Ann Allergy Asthma Immunol. 2022-09;129(3):378-380.
volume: 129

Tobacco and Alcohol and Cannabis Experience Questionnaires. Greek translation and test-retest reliability.
pmid: 35621255
abstract: The Tobacco and Alcohol Questionnaire (TAQ) and the Cannabis Experience Questionnaire (CEQ) are two instruments employed in the evaluation of substance use. The First Episode Psychosis (FEP) study in Athens employed two versions of those questionnaires, as part of a battery of psychometric tools, detecting environmental and genetic factors associated with FEP and addressed specifically to the distinctive characteristics of patients with FEP. The goal of the present study is to present those two versions, regarding their content, their use in international research, their translation in Greek, and their test-retest reliability. The two questionnaires were translated by two independent translators and administered to 32 subjects with FEP twice, in order to be tested for test-retest reliability. Cohen's kappa was used to measure agreement between qualitative variables and ICC between quantitative variables. Significant agreement was found between the two measurements in all items of the TAQ version and almost all items of the CEQ version. Our study is an indication that both translations are reliable, although a more thorough test of their psychometric properties is needed. Both might be used in the Greek research field as part of a broad package of psychometric tools, specifically addressed to patients with FEP.
doi: 10.22365/jpsych.2022.082
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Kollias K
      type: Person
      first name: Konstantinos
      last name: Kollias
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 2
    item: Xenaki LA
      type: Person
      first name: Lida-Alkisti
      last name: Xenaki
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 3
    item: Stefanatou P
      type: Person
      first name: Pentagiotissa
      last name: Stefanatou
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 4
    item: Vlachos I
      type: Person
      first name: Ilias
      last name: Vlachos
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 5
    item: Dimitrakopoulos S
      type: Person
      first name: Stefanos
      last name: Dimitrakopoulos
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 6
    item: Selakovic M
      type: Person
      first name: Mirjana
      last name: Selakovic
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 7
    item: Ralli I
      type: Person
      first name: Irene
      last name: Ralli
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 8
    item: Ntigrintaki AA
      type: Person
      first name: Angeliki-Aikaterini
      last name: Ntigrintaki
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
  slot:
    index: 9
    item: Stefanis N
      type: Person
      first name: Nikos
      last name: Stefanis
      member of: First Psychiatric Department of National and Kapodistrian University, Eginition Hospital, Athens, Greece.
created: 2022-5-28T06:00
date last updated: 2025-01-17
issued: 2022-12-07
dp: 2022 Dec 07
created: 2022-5-27T07:42
ISSN: 1105-2333
has issn l: 1105-2333
issue: 4
has NLM journal title abbreviation: Psychiatriki
publication name: Psychiatrike = Psychiatriki
language: eng
has national library of medicine journal id: 101534363
derived from: NLM
starting page: 317
ending page: 322
has place of publication: Greece
has primary subject term: D002188
has subject term: D006801
has subject term: D015203
has subject term: D014177
has subject term: D011795
has subject term: D011594
has subject term: D000431
source: Psychiatriki. 2022-12-07;33(4):317-322.
volume: 33

Japan Tobacco corporate social responsibility activities misleadingly claim to advance Sustainable Development Goals.
pmid: 36167827
has PII: tc-2022-057630
doi: 10.1136/tc-2022-057630
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Hirano T
      type: Person
      first name: Tomoyasu
      last name: Hirano
      member of: Institute for Cancer Control, National Cancer Center, Tokyo, Japan tohirano@ncc.go.jp.
created: 2022-9-28T06:00
date last updated: 2025-01-17
issued: 2024-04-19
dp: 2024 Apr 19
created: 2022-9-27T23:56
e ISSN: 1468-3318
has issn l: 0964-4563
issue: 3
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 417
ending page: 418
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000076502
has primary subject term: D019460
has subject term: D006801
has subject term: D007564
has subject term: D000329
has subject term: D012941
source: Tob Control. 2024-04-19;33(3):417-418.
volume: 33

Pharmacokinetics of freebase nicotine and nicotine salts following subcutaneous administration in male rats.
pmid: 36059224
abstract: Nicotine lactate, nicotine tartrate, nicotine benzoate, and freebase nicotine (FBN) are four forms of nicotine salt systems that are present in tobacco products. However, few in vivo studies have compared their pharmacological (pK) efficacies, which are important for understanding their roles in the addiction and abuse of tobacco and nicotine products. In this work, the pK of the above nicotine salt systems was studied by subcutaneously injecting their aqueous solutions in rats and obtaining blood samples from the jugular vein. Nicotine levels in the blood were analyzed by LC-MS/MS. The results demonstrated that rapid nicotine absorption occurred in all nicotine systems. Of them, NB had the smallest Tmax , while FBN had the largest Tmax . The nicotine metabolic rate and clearance decreased for FBN, indicating that nicotine retention in the body was higher than for the other three salt-based systems. Compared with nicotine salts, FBN could reach and maintain a higher concentration in the animal model. Additionally, as the benzoic acid ratios increased, the Cmax of the nicotine benzoate (NB) in the plasma decreased. This indicates that the lower the pH, the lower the Cmax . When different concentrations of NB were used, the higher the NB concentration, the greater the Cmax and AUC(0-t) . These results demonstrate that nicotine adsorption by NB in the animal model depended on both pH and concentration. This baseline information could be used to explain different clinical pharmacological observations in humans, though this study only considered the effects of nicotine on pharmacokinetics in vivo.
rights: © 2022 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.
doi: 10.1002/dta.3363
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Han S
      type: Person
      first name: Shulei
      last name: Han
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 2
    item: Liu C
      type: Person
      first name: Chuan
      last name: Liu
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
  slot:
    index: 3
    item: Chen H
      type: Person
      first name: Huan
      last name: Chen
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 4
    item: Fu Y
      type: Person
      first name: Ya'ning
      last name: Fu
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 5
    item: Zhang Y
      type: Person
      first name: Yuan
      last name: Zhang
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 6
    item: Miao R
      type: Person
      first name: Ruijuan
      last name: Miao
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 7
    item: Ren P
      type: Person
      first name: Peipei
      last name: Ren
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 8
    item: Yu P
      type: Person
      first name: Pengpeng
      last name: Yu
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 9
    item: Shi Z
      type: Person
      first name: Zhihao
      last name: Shi
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 10
    item: Tian Y
      type: Person
      first name: Yushan
      last name: Tian
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 11
    item: Wang H
      type: Person
      first name: Hongjuan
      last name: Wang
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 12
    item: Liu T
      type: Person
      first name: Tong
      last name: Liu
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 13
    item: Hou H
      type: Person
      first name: Hongwei
      last name: Hou
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
  slot:
    index: 14
    item: Hu Q
      type: Person
      first name: Qingyuan
      last name: Hu
      member of: China National Tobacco Quality Supervision and Test Center, Zhengzhou, China.Key Laboratory of Tobacco Biological Effects, Zhengzhou, China.
created: 2022-9-6T06:00
date last updated: 2025-01-17
issued: 2023-10
dp: 2023 Oct
created: 2022-9-5T03:13
e ISSN: 1942-7611
has issn l: 1942-7603
issue: 10
has NLM journal title abbreviation: Drug Test Anal
publication name: Drug testing and analysis
language: eng
has national library of medicine journal id: 101483449
derived from: NLM
starting page: 1099
ending page: 1106
has place of publication: England
has primary subject term: D009538
has primary subject term: D066300
has subject term: D006801
has subject term: D008297
has subject term: D051381
has subject term: D000818
has subject term: D012492
has subject term: D002853
has subject term: D053719
has subject term: D001565
source: Drug Test Anal. 2023-10;15(10):1099-1106.
volume: 15

Diversity and sex differences in rectal gland volatiles of Queensland fruit fly, Bactrocera tryoni (Diptera: Tephritidae).
pmid: 36001616
abstract: Rectal gland volatiles are key mediators of sexual interactions in tephritid fruit flies. We used solid-phase microextraction (SPME) plus gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID) to substantially expand rectal gland chemical characterisation of the Queensland fruit fly (Bactrocera tryoni (Diptera: Tephritidae); Qfly). The SPME GC-MS analysis identified 24 of the 30 compounds previously recorded from Qfly rectal glands, plus another 21 compounds that had not previously been reported. A few amides and fatty acid esters dominated the chromatograms of males and females respectively, but we also found other esters, alcohols and aldehydes and a ketone. The GC-FID analyses also revealed over 150 others, as yet unidentified, volatiles, generally in lesser amounts. The GC-FID analyses also showed 49 and 12 compounds were male- and female-specific, respectively, both in single sex (virgin) and mixed sex (mostly mated) groups. Another ten compounds were male-specific among virgins but undetected in mixed sex groups, and 29 were undetected in virgins but male-specific in mixed sex groups. The corresponding figures for females were four and zero, respectively. Most short retention time peaks (including a ketone and an ester) were male-specific, whereas most female-biased peaks (including five fatty acid esters) had long retention times. Our results indicate previously unsuspected diversity of rectal gland volatiles that might have pheromone functions in males, but far fewer in females.
has PII: PONE-D-21-34886
doi: 10.1371/journal.pone.0273210
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Castro-Vargas C
      type: Person
      first name: Cynthia
      last name: Castro-Vargas
      member of: Land and Water, Commonwealth Scientific and Industrial Research Organisation, Black Mountain, ACT, Australia.Applied BioSciences, Macquarie University, North Ryde, NSW, Australia.Australian Research Council Centre for Fruit Fly Biosecurity Innovation, Macquarie University, North Ryde, NSW, Australia.
  slot:
    index: 2
    item: Pandey G
      type: Person
      first name: Gunjan
      last name: Pandey
      member of: Land and Water, Commonwealth Scientific and Industrial Research Organisation, Black Mountain, ACT, Australia.Applied BioSciences, Macquarie University, North Ryde, NSW, Australia.
  slot:
    index: 3
    item: Yeap HL
      type: Person
      first name: Heng Lin
      last name: Yeap
      member of: Land and Water, Commonwealth Scientific and Industrial Research Organisation, Black Mountain, ACT, Australia.Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia.
  slot:
    index: 4
    item: Lacey MJ
      type: Person
      first name: Michael J
      last name: Lacey
      member of: National Collections and Marine Infrastructure, Commonwealth Scientific and Industrial Research Organisation, Black Mountain, ACT, Australia.
  slot:
    index: 5
    item: Lee SF
      type: Person
      first name: Siu Fai
      last name: Lee
      member of: Land and Water, Commonwealth Scientific and Industrial Research Organisation, Black Mountain, ACT, Australia.Applied BioSciences, Macquarie University, North Ryde, NSW, Australia.Australian Research Council Centre for Fruit Fly Biosecurity Innovation, Macquarie University, North Ryde, NSW, Australia.
  slot:
    index: 6
    item: Park SJ
      type: Person
      first name: Soo J
      last name: Park
      member of: Applied BioSciences, Macquarie University, North Ryde, NSW, Australia.Australian Research Council Centre for Fruit Fly Biosecurity Innovation, Macquarie University, North Ryde, NSW, Australia.
  slot:
    index: 7
    item: Taylor PW
      type: Person
      first name: Phillip W
      last name: Taylor
      member of: Applied BioSciences, Macquarie University, North Ryde, NSW, Australia.Australian Research Council Centre for Fruit Fly Biosecurity Innovation, Macquarie University, North Ryde, NSW, Australia.
  slot:
    index: 8
    item: Oakeshott JG
      type: Person
      first name: John G
      last name: Oakeshott
      member of: Land and Water, Commonwealth Scientific and Industrial Research Organisation, Black Mountain, ACT, Australia.Applied BioSciences, Macquarie University, North Ryde, NSW, Australia.
created: 2022-8-25T06:00
date last updated: 2025-01-17
issued: 2022
dp: 2022
created: 2022-8-24T13:44
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 8
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0273210
has place of publication: United States
has primary subject term: D033621
has subject term: D000818
has subject term: D005227
has subject term: D005260
has subject term: D008401
has subject term: D007659
has subject term: D008297
has subject term: D012491
has subject term: D012727
source: PLoS One. 2022;17(8):e0273210.
volume: 17

Visible-light driven reaction of CO2 with alcohols using a Ag/CeO2 nanocomposite: first photochemical synthesis of linear carbonates under mild conditions.
pmid: 36636985
abstract: The first photochemical synthesis of linear carbonates from the reaction of CO2 with alcohols using a silver-doped ceria nanocomposite at room temperature under visible light irradiation is described. DFT calculations suggested the electron transfer from Ag 4d states to Ce 4f states in the composite for the photoreaction.
doi: 10.1039/d2cc05152d
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Malik A
      type: Person
      first name: Anil
      last name: Malik
      member of: Chemical & Material Sciences Division, CSIR-Indiam Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.Academy of Scientific and Innovative Research, Ghaziabad-201002, India.
  slot:
    index: 2
    item: Bhatt S
      type: Person
      first name: Sakshi
      last name: Bhatt
      member of: Chemical & Material Sciences Division, CSIR-Indiam Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.Academy of Scientific and Innovative Research, Ghaziabad-201002, India.
  slot:
    index: 3
    item: Soni A
      type: Person
      first name: Aishwarya
      last name: Soni
      member of: Chemical & Material Sciences Division, CSIR-Indiam Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 4
    item: Khatri PK
      type: Person
      first name: Praveen K
      last name: Khatri
      member of: Chemical & Material Sciences Division, CSIR-Indiam Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
  slot:
    index: 5
    item: Guha AK
      type: Person
      first name: Ankur K
      last name: Guha
      member of: Department of Chemistry, Cotton University, Guwahati-781001, Assam, India.
  slot:
    index: 6
    item: Saikia L
      type: Person
      first name: Lakshi
      last name: Saikia
      member of: Advanced Materials Group, Materials Sciences & Technology Division, CSIR-NEIST, Jorhat-785006, Assam, India.
  slot:
    index: 7
    item: Jain SL
      type: Person
      first name: Suman L
      last name: Jain
      member of: Chemical & Material Sciences Division, CSIR-Indiam Institute of Petroleum, Haridwar Road, Mohkampur, Dehradun-248005, India. suman@iip.res.in.
created: 2023-1-14T06:00
date last updated: 2025-01-17
issued: 2023-01-31
dp: 2023 Jan 31
created: 2023-1-13T05:43
e ISSN: 1364-548X
has issn l: 1359-7345
issue: 10
has NLM journal title abbreviation: Chem Commun (Camb)
publication name: Chemical communications (Cambridge, England)
language: eng
has national library of medicine journal id: 9610838
derived from: NLM
starting page: 1313
ending page: 1316
has place of publication: England
source: Chem Commun (Camb). 2023-01-31;59(10):1313-1316.
volume: 59

Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[def,p]chrysene in Human Oral Cells.
pmid: 36260657
abstract: In a series of previous studies we reported that black raspberry (BRB) powder inhibits dibenzo[a,l]pyrene (DBP)-induced DNA damage, mutagenesis, and oral squamous cell carcinoma (OSCC) development in mice. In the present study, using human oral leukoplakia (MSK-Leuk1) and squamous cell carcinoma (SCC1483) cells, we tested the hypothesis that BRB extract (BRBE) will enhance the synthesis of glutathione (GSH) and in turn increase GSH conjugation of the fjord-region DBP diol epoxide (DBPDE) derived from DBP leading to inhibition of DBP-induced DNA damage. The syntheses of DBPDE-GSH conjugate, DBPDE-dA adduct, and the corresponding isotope-labeled internal standards were performed; LC-MS/MS methods were used for their quantification. BRBE significantly (p < 0.05) increased cellular GSH by 31% and 13% at 6 and 24 h, respectively, in OSCC cells; in MSK-LeuK1 cells, the levels of GSH significantly (p < 0.05) increased by 55% and 22%, at 1 and 6 h. Since BRBE significantly enhanced the synthesis of GSH in both cell types, subsequent experiments were performed in MSK-Leuk1 cells. Western blot analysis was performed to determine the types of proteins involved in the synthesis of GSH. BRBE significantly (p < 0.05) increased the protein expression (2.5-fold) of the glutamate-cysteine ligase catalytic subunit (GCLC) but had no effect on the glutamate-cysteine ligase modifier subunit (GCLM) and glutathione synthetase (GSS). LC-MS/MS analysis showed that pretreatment of cells with BRBE followed by DBPDE significantly (p < 0.05) increased the levels of DBPDE-GSH conjugate (2.5-fold) and decreased DNA damage by 74% measured by assessing levels of DBPDE-dA adduct formation. Collectively, the results of this in vitro study clearly support our hypothesis, and the LC-MS/MS methods developed in the present study will be highly useful in testing the same hypothesis initially in our mouse model and ultimately in smokers.
doi: 10.1021/acs.chemrestox.2c00246
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Chen KM
      type: Person
      first name: Kun-Ming
      last name: Chen
  slot:
    index: 2
    item: Sun YW
      type: Person
      first name: Yuan-Wan
      last name: Sun
  slot:
    index: 3
    item: Sun D
      type: Person
      first name: Dongxiao
      last name: Sun
  slot:
    index: 4
    item: Gowda K
      type: Person
      first name: Krishne
      last name: Gowda
  slot:
    index: 5
    item: Amin S
      type: Person
      first name: Shantu
      last name: Amin
  slot:
    index: 6
    item: El-Bayoumy K
      type: Person
      first name: Karam
      last name: El-Bayoumy
created: 2022-10-20T06:00
date last updated: 2025-01-17
issued: 2022-11-21
dp: 2022 11 21
created: 2022-10-19T13:53
e ISSN: 1520-5010
has issn l: 0893-228X
issue: 11
has NLM journal title abbreviation: Chem Res Toxicol
publication name: Chemical research in toxicology
language: eng
has national library of medicine journal id: 8807448
derived from: NLM
starting page: 2152
ending page: 2159
has place of publication: United States
has primary subject term: D065856
has primary subject term: D002294
has primary subject term: D009062Q000139
has subject term: D006801
has subject term: D051379
has subject term: D000818
has subject term: D002273
has subject term: D002911
has subject term: D001580Q000378
has subject term: D004852
has subject term: D005721
has subject term: D018736
has subject term: D002853
has subject term: D063366
has subject term: D053719
has subject term: D005978Q000378
has subject term: D010936Q000494
source: Chem Res Toxicol. 2022-11-21;35(11):2152-2159.
volume: 35

Genetic polymorphisms of muscular fitness in young healthy men.
pmid: 36166425
abstract: The effects of genetic polymorphisms on muscle structure and function remain elusive. The present study tested for possible associations of 16 polymorphisms (across ten candidate genes) with fittness and skeletal muscle phenotypes in 17- to 37-year-old healthy Caucasian male endurance (n = 86), power/strength (n = 75) and team athletes (n = 60), and non-athletes (n = 218). Skeletal muscle function was measured with eight performance tests covering multiple aspects of muscular fitness. Along with body mass and height, the upper arm and limb girths, and maximal oxygen uptake were measured. Genotyping was conducted on DNA extracted from blood. Of the 16 polymorphisms studied, nine (spanning seven candidate genes and four gene families/signalling pathways) were independently associated with at least one skeletal muscle fitness measure (size or function, or both) measure and explained up to 4.1% of its variation. Five of the studied polymorphisms (activin- and adreno-receptors, as well as myosine light chain kinase 1) in a group of one to three combined with body height, age and/or group explained up to 20.4% of the variation of muscle function. ACVR1B (rs2854464) contributed 2.0-3.6% to explain up to 14.6% of limb proximal girths. The G allele (genotypes AG and GG) of the ACVR1B (rs2854464) polymorphism was significantly overrepresented among team (60.4%) and power (62.0%) athletes compared to controls (52.3%) and endurance athletes (39.2%), and G allele was also most consistently/frequently associated with muscle size and power. Overall, the investigated polymorphisms determined up to 4.1% of the variability of muscular fitness in healthy young humans.
has PII: PONE-D-22-13831
doi: 10.1371/journal.pone.0275179
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Venckunas T
      type: Person
      first name: Tomas
      last name: Venckunas
      member of: Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.
  slot:
    index: 2
    item: Degens H
      type: Person
      first name: Hans
      last name: Degens
      member of: Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania.Department of Life Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom.
created: 2022-9-28T06:00
date last updated: 2025-01-17
issued: 2022
dp: 2022
created: 2022-9-27T13:33
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 9
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0275179
has place of publication: United States
has primary subject term: D056352
has primary subject term: D015444Q000502
has subject term: D028341Q000235
has subject term: D000293
has subject term: D000328
has subject term: D006801
has subject term: D008297
has subject term: D053580Q000235
has subject term: D018482Q000502
has subject term: D010100
has subject term: D010807Q000235
has subject term: D011110
has subject term: D055815
source: PLoS One. 2022;17(9):e0275179.
volume: 17

Associations between prenatal and postnatal substance exposure and salivary C-reactive protein in early childhood.
pmid: 36395973
abstract: Exposure to tobacco and cannabis during developmental periods of enhanced vulnerability (e.g., in utero and early childhood) may have long-lasting effects on child health. One potential mechanism underlying these associations is the alteration of inflammatory pathways. Using data from a longitudinal study of mother/child dyads, we examined the adjusted and combined associations of prenatal and postnatal tobacco and cannabis exposure with inflammation in early childhood. Furthermore, we explored the relations between different measures of exposure, partly reflecting differences in timing, dose, and level of fetal exposure (e.g., self-report vs. biomarker), and inflammation. Finally, we explored child sex as a moderator of prenatal and postnatal tobacco and cannabis exposure and inflammation.Women were recruited from a local hospital during their first prenatal appointment. Repeated assessments were conducted at each trimester, at birth, and when children were 2, 9, 16, 24, 36, and 60 months old (N = 215; 112 female children). To evaluate associations with different measurement approaches, prenatal tobacco and cannabis exposure were assessed using: 1) continuous dose-response variables of maternal self-reported tobacco and cannabis use during each trimester to assess associations with timing and severity of exposure, 2) categorization of children into exposure groups based on drugs and metabolites present in infant meconium reflecting later pregnancy fetal exposure, and 3) categorization into exposure groups using a combination of maternal self-report data and biomarker data derived from maternal saliva samples and infant meconium taking advantage of multiple methods of assessment to examine group differences. Postnatal exposure to tobacco (assessed using child salivary cotinine) and cannabis (assessed using maternal self-reported average joints smoked per day) was measured at each infancy/early childhood assessment. Adjusted pre- and postnatal exposure associations w[cell cut: 4221 characters, first 2000 kept]
rights: Copyright © 2022. Published by Elsevier Inc.
has PII: S0892-0362(22)00072-1
doi: 10.1016/j.ntt.2022.107134
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Simon SG
      type: Person
      first name: Shauna G
      last name: Simon
      member of: Department of Psychological Science, School of Social Ecology, University of California Irvine, Irvine, CA, USA. Electronic address: sgsimon@uci.edu.
  slot:
    index: 2
    item: Eiden RD
      type: Person
      first name: Rina D
      last name: Eiden
      member of: Department of Psychology & Consortium for Combating Substance Abuse, The Pennsylvania State University, University Park, PA, USA.
  slot:
    index: 3
    item: Molnar DS
      type: Person
      first name: Danielle S
      last name: Molnar
      member of: Department of Child and Youth Studies, Brock University, St. Catharines, ON, Canada.
  slot:
    index: 4
    item: Huestis MA
      type: Person
      first name: Marilyn A
      last name: Huestis
      member of: Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 5
    item: Riis JL
      type: Person
      first name: Jenna L
      last name: Riis
      member of: Department of Psychological Science, School of Social Ecology, University of California Irvine, Irvine, CA, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA, USA.
created: 2022-11-18T06:00
date last updated: 2025-01-17
created: 2022-11-17T19:25
e ISSN: 1872-9738
has issn l: 0892-0362
has NLM journal title abbreviation: Neurotoxicol Teratol
publication name: Neurotoxicology and teratology
language: eng
has national library of medicine journal id: 8709538
derived from: NLM
pg: 107134
has place of publication: United States
has primary subject term: D002188Q000009
has primary subject term: D011297Q000378
has subject term: D002675
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D008297
has subject term: D011247
has subject term: D015415Q000032
has subject term: D002097Q000032
has subject term: D007249
has subject term: D008137
has subject term: D014028Q000009
source: Neurotoxicol Teratol. ;95():107134.
volume: 95

DNA methylation as a potential mediator of the association between prenatal tobacco and alcohol exposure and child neurodevelopment in a South African birth cohort.
pmid: 36180424
abstract: Prenatal tobacco exposure (PTE) and prenatal alcohol exposure (PAE) have been associated with an increased risk of delayed neurodevelopment in children as well as differential newborn DNA methylation (DNAm). However, the biological mechanisms connecting PTE and PAE, DNAm, and neurodevelopment are largely unknown. Here we aim to determine whether differential DNAm mediates the association between PTE and PAE and neurodevelopment at 6 (N = 112) and 24 months (N = 184) in children from the South African Drakenstein Child Health Study. PTE and PAE were assessed antenatally using urine cotinine measurements and the ASSIST questionnaire, respectively. Cord blood DNAm was measured using the EPIC and 450 K BeadChips. Neurodevelopment (cognitive, language, motor, adaptive behavior, socioemotional) was measured using the Bayley Scales of Infant and Toddler Development, Third Edition. We constructed methylation risk scores (MRS) for PTE and PAE and conducted causal mediation analysis (CMA) with these MRS as mediators. Next, we conducted a high-dimensional mediation analysis to identify individual CpG sites as potential mediators, followed by a CMA to estimate the average causal mediation effects (ACME) and total effect (TE). PTE and PAE were associated with neurodevelopment at 6 but not at 24 months. PTE MRS reached a prediction accuracy (R2) of 0.23 but did not significantly mediate the association between PTE and neurodevelopment. PAE MRS was not predictive of PAE (R2 = 0.006). For PTE, 31 CpG sites and eight CpG sites were identified as significant mediators (ACME and TE P < 0.05) for the cognitive and motor domains at 6 months, respectively. For PAE, 16 CpG sites and 1 CpG site were significant mediators for the motor and adaptive behavior domains at 6 months, respectively. Several of the associated genes, including MAD1L1, CAMTA1, and ALDH1A2 have been implicated in neurodevelopmental delay, suggesting that differential DNAm may partly explain the biological mechanisms un[cell cut: 2073 characters, first 2000 kept]
rights: © 2022. The Author(s).
has PII: 10.1038/s41398-022-02195-3
doi: 10.1038/s41398-022-02195-3
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Abrishamcar S
      type: Person
      first name: Sarina
      last name: Abrishamcar
      member of: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  slot:
    index: 2
    item: Chen J
      type: Person
      first name: Junyu
      last name: Chen
      member of: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  slot:
    index: 3
    item: Feil D
      type: Person
      first name: Dakotah
      last name: Feil
      member of: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  slot:
    index: 4
    item: Kilanowski A
      type: Person
      first name: Anna
      last name: Kilanowski
      member of: Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.Institute for Medical Information Processing, Biometry, and Epidemiology, Pettenkofer School of Public Health, LMU Munich, Munich, Germany.Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
  slot:
    index: 5
    item: Koen N
      type: Person
      first name: Nastassja
      last name: Koen
      member of: Neuroscience Institute, University of Cape Town, Cape Town, South Africa.South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
  slot:
    index: 6
    item: Vanker A
      type: Person
      first name: Aneesa
      last name: Vanker
      member of: Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  slot:
    index: 7
    item: Wedderburn CJ
      type: Person
      first name: Catherine J
      last name: Wedderburn
      member of: Neuroscience Institute, University of Cape Town, Cape Town, South Africa.Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
  slot:
    index: 8
    item: Donald KA
      type: Person
      first name: Kirsten A
      last name: Donald
      member of: Neuroscience Institute, University of Cape Town, Cape Town, South Africa.Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  slot:
    index: 9
    item: Zar HJ
      type: Person
      first name: Heather J
      last name: Zar
      member of: South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  slot:
    index: 10
    item: Stein DJ
      type: Person
      first name: Dan J
      last name: Stein
      member of: Neuroscience Institute, University of Cape Town, Cape Town, South Africa.South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
  slot:
    index: 11
    item: Hüls A
      type: Person
      first name: Anke
      last name: Hüls
      member of: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. anke.huels@emory.edu.Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. anke.huels@emory.edu.
created: 2022-10-1T06:00
date last updated: 2025-01-17
issued: 2022-09-30
dp: 2022 09 30
created: 2022-9-30T23:15
e ISSN: 2158-3188
has issn l: 2158-3188
issue: 1
has NLM journal title abbreviation: Transl Psychiatry
publication name: Translational psychiatry
language: eng
has national library of medicine journal id: 101562664
derived from: NLM
pg: 418
has place of publication: United States
has primary subject term: D011297Q000139
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D011247
has subject term: http://id.nlm.nih.gov/mesh/D000089822
has subject term: D002657
has subject term: D003367
has subject term: D019175
has subject term: D000431
has subject term: D013019
has subject term: D014028Q000009
source: Transl Psychiatry. 2022-09-30;12(1):418.
volume: 12

Effect of Club cell secretory proteins on the association of tobacco smoke and PAH co-exposure with lung function decline: A longitudinal observation of Chinese coke oven workers.
pmid: 36334377
abstract: Exposure to polycyclic aromatic hydrocarbons (PAH) and tobacco smoke is associated with epithelial damage and reduced lung function. Club cell secretory protein (CC16) is a known biomarker for lung epithelial cells. However, the potential relationships between PAH and tobacco smoke exposure, CC16 levels, and reduced lung function remain unclear.This longitudinal study aimed to explore the potential role of CC16 in the association of tobacco smoke and PAH co-exposure with lung function.We enrolled 313 workers from a coking plant in China in 2014 and followed them up in 2019. The concentrations of PAH and nicotine metabolites in urine were determined using high-performance liquid chromatography (HPLC) with a fluorescence detector and HPLC-tandem mass spectrometry, respectively. The plasma CC16 concentration was determined using an enzyme-linked immunosorbent assay.An analysis of the generalized estimating equation showed that each 1-unit increase in log-transformation of the last tertile of trans-3'-hydroxycotinine (3HC) was associated with a 3.30 ng/ml decrease in CC16. Restricted cubic spline analysis revealed a significant nonlinear dose-effect association between cotinine (COT) and CC16 (Pnonlinear = 0.018). In the low- CC16 subgroup, we found a significant association between total nicotine metabolites and forced vital capacity (FVC%) (β: 1.45, 95% CI: 2.87, -0.03), and the associations of nicotine (NIC), COT, and 3HC with FVC% were all of marginal significance. High levels of total hydroxyl polycyclic aromatic hydrocarbons (ΣOH-PAH) and NIC in the urine had an interactive effect on the decline of CC16 (P < 0.05). Cross-lagged panel analysis indicated that the decrease in CC16 preceded the decrease in FVC%. CC16 mediated the association between elevated nicotine metabolites and decreased FVC% in the low- CC16 subgroup.CC16 plays an essential role in the association of PAH and tobacco smoke exposure with reduced lung function. Coke oven workers with low plasma CC1[cell cut: 2092 characters, first 2000 kept]
rights: Copyright © 2022 Elsevier GmbH. All rights reserved.
has PII: S1438-4639(22)00141-9
doi: 10.1016/j.ijheh.2022.114058
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Liu L
      type: Person
      first name: Lu
      last name: Liu
      member of: Department of Occupational Health, School of Public Health, Shanxi Medical University, China; NHC Key Laboratory of Pneumoconiosis, China.
  slot:
    index: 2
    item: Wei J
      type: Person
      first name: Jiajun
      last name: Wei
      member of: Department of Occupational Health, School of Public Health, Shanxi Medical University, China; NHC Key Laboratory of Pneumoconiosis, China.
  slot:
    index: 3
    item: Wang Y
      type: Person
      first name: Yong
      last name: Wang
      member of: Department of Occupational Health, School of Public Health, Shanxi Medical University, China; NHC Key Laboratory of Pneumoconiosis, China.
  slot:
    index: 4
    item: Feng Q
      type: Person
      first name: Quan
      last name: Feng
      member of: Department of Occupational Health, School of Public Health, Shanxi Medical University, China; NHC Key Laboratory of Pneumoconiosis, China.
  slot:
    index: 5
    item: Guo S
      type: Person
      first name: Shugang
      last name: Guo
      member of: Shanxi Provincial Center for Disease Control and Prevention, China.
  slot:
    index: 6
    item: Liu G
      type: Person
      first name: Gaisheng
      last name: Liu
      member of: Center of Occupational Disease Prevention, Xishan Coal Electricity (Group) Co., Ltd, China.
  slot:
    index: 7
    item: Dong J
      type: Person
      first name: Jun
      last name: Dong
      member of: Center of Occupational Disease Prevention, Xishan Coal Electricity (Group) Co., Ltd, China.
  slot:
    index: 8
    item: Jiang L
      type: Person
      first name: Liuquan
      last name: Jiang
      member of: Center of Occupational Disease Prevention, Xishan Coal Electricity (Group) Co., Ltd, China.
  slot:
    index: 9
    item: Li Q
      type: Person
      first name: Qiang
      last name: Li
      member of: Center of Occupational Disease Prevention, Xishan Coal Electricity (Group) Co., Ltd, China.
  slot:
    index: 10
    item: Nie J
      type: Person
      first name: Jisheng
      last name: Nie
      member of: Department of Occupational Health, School of Public Health, Shanxi Medical University, China; NHC Key Laboratory of Pneumoconiosis, China.
  slot:
    index: 11
    item: Yang J
      type: Person
      first name: Jin
      last name: Yang
      member of: Department of Occupational Health, School of Public Health, Shanxi Medical University, China; NHC Key Laboratory of Pneumoconiosis, China. Electronic address: yang_jin@sxmu.edu.cn.
created: 2022-11-6T06:00
date last updated: 2025-01-17
issued: 2023-01
dp: 2023 01
created: 2022-11-5T19:11
e ISSN: 1618-131X
has issn l: 1438-4639
has NLM journal title abbreviation: Int J Hyg Environ Health
publication name: International journal of hygiene and environmental health
language: eng
has national library of medicine journal id: 100898843
derived from: NLM
pg: 114058
has place of publication: Germany
has primary subject term: D011084Q000652
has primary subject term: D003077Q000032
has primary subject term: D014028Q000032
has primary subject term: D016273Q000009Q000032
has subject term: D006801
has subject term: D009538Q000032
has subject term: D008137
has subject term: D008168Q000737
has subject term: D004847Q000378
source: Int J Hyg Environ Health. 2023-01;247():114058.
volume: 247

Paraventricular Nucleus of the Hypothalamus Oxytocin and Incubation of Heroin Seeking.
pmid: 36709749
abstract: There are numerous pharmacologic treatments for opioid use disorder (OUD), but none that directly target the underlying addictive effects of opioids. Oxytocin, a peptide hormone produced in the paraventricular nucleus (PVN) of the hypothalamus, has been investigated as a potential therapeutic for OUD. Promising preclinical and clinical results have been reported, but the brain region(s) and mechanism(s) by which oxytocin impacts reward processes remain undetermined.Here, we assess peripherally administered oxytocin's impacts on cued reinstatement of heroin seeking following forced abstinence and its effects on neuronal activation in the PVN and key projection regions. We also examine how designer receptors exclusively activated by designer drug (DREADD)-mediated activation or inhibition of oxytocinergic PVN neurons alters cued heroin seeking and social interaction.As predicted, peripheral oxytocin administration successfully decreased cued heroin seeking on days 1 and 30 of abstinence. Oxytocin administration also led to increased neuronal activity within the PVN and the central amygdala (CeA). Activation of oxytocinergic PVN neurons with an excitatory (Gq) DREADD did not impact cued reinstatement or social interaction. In contrast, suppression with an inhibitory (Gi) DREADD reduced heroin seeking on abstinence day 30 and decreased time spent interacting with a novel conspecific.These findings reinforce oxytocin's therapeutic potential for OUD, the basis for which may be driven in part by increased PVN-CeA circuit activity. Our results also suggest that oxytocin has distinct signaling and/or other mechanisms of action to produce these effects, as inhibition, but not activation, of oxytocinergic PVN neurons did not recapitulate the suppression in heroin seeking.
rights: © 2023 The Author(s). Published by S. Karger AG, Basel.
has PII: 000529358
doi: 10.1159/000529358
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Carter JS
      type: Person
      first name: Jordan S
      last name: Carter
      member of: Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA, carterjo@musc.edu.
  slot:
    index: 2
    item: Wood SK
      type: Person
      first name: Samuel K
      last name: Wood
      member of: Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
  slot:
    index: 3
    item: Kearns AM
      type: Person
      first name: Angela M
      last name: Kearns
      member of: Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
  slot:
    index: 4
    item: Hopkins JL
      type: Person
      first name: Jordan L
      last name: Hopkins
      member of: Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
  slot:
    index: 5
    item: Reichel CM
      type: Person
      first name: Carmela M
      last name: Reichel
      member of: Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
created: 2023-1-30T06:00
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-1-29T18:20
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 11
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1112
ending page: 1126
has place of publication: Switzerland
has primary subject term: D010286
has primary subject term: D010121Q000494
has subject term: D003932Q000494
has subject term: D007031
has subject term: D001921
source: Neuroendocrinology. 2023;113(11):1112-1126.
volume: 113

Content analysis of Dutch newspaper coverage of three tobacco control policies, 2017-2019.
pmid: 36764730
abstract: News media coverage can influence support for and implementation of tobacco control policies. This research aims to analyse and compare newspaper coverage of newly implemented policies: a substantial tobacco tax increase, point-of-sale display ban and plain packaging.We conducted a content analysis of articles covering the three policies from ten national Dutch newspapers. Articles published between November 2017 and November 2019 were coded for type and tone. The policy dystopia model was used to code arguments opposing the policies. Tobacco industry appearances in news articles were also analysed for frequency and type.A total of 134 news articles were analysed, of which the industry appeared in 28%. The majority of coverage was neutral in tone, although among articles that were coded as expressing a positive or negative tone, plain packaging and the point-of-sale ban were portrayed more negatively than positively. Negative coverage was predominantly accounted for by industry presence. Arguments opposing the policies focused on negative economic consequences, challenging the need for policy and adverse consequences for retailers for tax, plain packaging and the point-of-sale display ban, respectively. We identified six specific new arguments that fit within existing domains of the policy dystopia model.The tobacco industry and its allies still appear in a substantial proportion of news articles in relation to tobacco policy. This study identifies contemporary industry arguments against tobacco control policies in Europe which, alongside the policy dystopia model, can be used to predict and counter the tobacco industry's future attempts to oppose policies.
rights: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: bmjopen-2021-057912
doi: 10.1136/bmjopen-2021-057912
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Poole NL
      type: Person
      first name: Nikita L
      last name: Poole
      member of: IVO, The Hague, the Netherlands poole@ivo.nl.Department of Health Promotion, Maastricht University Care and Public Health Research Institute, Maastricht, the Netherlands.
  slot:
    index: 2
    item: van Straaten B
      type: Person
      first name: Barbara
      last name: van Straaten
      member of: IVO, The Hague, the Netherlands.
  slot:
    index: 3
    item: van den Brand FA
      type: Person
      first name: Floor A
      last name: van den Brand
      member of: Department of Family Medicine, Maastricht University Care and Public Health Research Institute, Maastricht, the Netherlands.
  slot:
    index: 4
    item: Gilmore AB
      type: Person
      first name: Anna B
      last name: Gilmore
      member of: Department for Health, University of Bath, Bath, UK.
  slot:
    index: 5
    item: Willemsen MC
      type: Person
      first name: Marc C
      last name: Willemsen
      member of: Department of Health Promotion, Maastricht University Care and Public Health Research Institute, Maastricht, the Netherlands.Drug Monitoring and Policy, Trimbos-instituut, Utrecht, the Netherlands.
  slot:
    index: 6
    item: Nagelhout GE
      type: Person
      first name: Gera E
      last name: Nagelhout
      member of: IVO, The Hague, the Netherlands.Department of Health Promotion, Maastricht University Care and Public Health Research Institute, Maastricht, the Netherlands.
created: 2023-2-11T06:00
date last updated: 2025-01-17
issued: 2023-02-10
dp: 2023 02 10
created: 2023-2-10T20:53
e ISSN: 2044-6055
has issn l: 2044-6055
issue: 2
has NLM journal title abbreviation: BMJ Open
publication name: BMJ open
language: eng
has national library of medicine journal id: 101552874
derived from: NLM
pg: e057912
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000092843
has primary subject term: D019460
has subject term: D006801
has subject term: D006291
has subject term: http://id.nlm.nih.gov/mesh/D000074606
has subject term: D008402
source: BMJ Open. 2023-02-10;13(2):e057912.
volume: 13

ERα Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core.
pmid: 36746131
abstract: The nucleus accumbens core (NAcc) is a sexually differentiated brain region that is modulated by steroid hormones such as 17β-estradiol (estradiol), with consequential impacts on relevant motivated behaviors and disorders such as addiction, anxiety, and depression. NAcc estradiol levels naturally fluctuate, including during the estrous cycle in adult female rats, which is analogous to the menstrual cycle in adult humans. Across the estrous cycle, excitatory synapse properties of medium spiny neurons rapidly change, as indicated by analysis of miniature excitatory postsynaptic currents (mEPSCs). mEPSC frequency decreases during estrous cycle phases associated with high estradiol levels. This decrease in mEPSC frequency is mimicked by acute topical exposure to estradiol. The identity of the estrogen receptor (ER) underlying this estradiol action is unknown. Adult rat NAcc expresses three ERs, all extranuclear: membrane ERα, membrane ERβ, and GPER1.In this brief report, we take a first step toward addressing this challenge by testing whether activation of ERs via acute topical agonist application is sufficient for inducing changes in mEPSC properties recorded via whole-cell patch clamp.An agonist of ERα induced large decreases in mEPSC frequency, while agonists of ERβ and GPER1 did not robustly modulate mEPSC properties.These data provide evidence that activation of ERα is sufficient for inducing changes in mEPSC frequency and is a likely candidate underlying the estradiol-induced changes observed during the estrous cycle. Overall, these findings extend our understanding of the neuroendocrinology of the NAcc and implicate ERα as a primary target for future studies.
rights: © 2023 S. Karger AG, Basel.
has PII: 000529571
doi: 10.1159/000529571
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Miller CK
      type: Person
      first name: Christiana K
      last name: Miller
      member of: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
  slot:
    index: 2
    item: Krentzel AA
      type: Person
      first name: Amanda A
      last name: Krentzel
      member of: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
  slot:
    index: 3
    item: Meitzen J
      type: Person
      first name: John
      last name: Meitzen
      member of: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, USA.Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA.
created: 2023-2-7T06:00
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-2-6T18:23
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 11
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1140
ending page: 1153
has place of publication: Switzerland
has primary subject term: D009714Q000378
has primary subject term: D011960
has subject term: D006801
has subject term: D051381
has subject term: D000818
has subject term: D005260
has subject term: D047628Q000378
has subject term: D047629
has subject term: D004958Q000494Q000502
has subject term: D013569Q000378
source: Neuroendocrinology. 2023;113(11):1140-1153.
volume: 113

Functional capacity testing in patients with pulmonary hypertension (PH) using the one-minute sit-to-stand test (1-min STST).
pmid: 36893125
abstract: The one-minute sit-to-stand-test (1-min STST) is a quick, space saving test to evaluate functional capacity. Exercise testing plays an important role in the long-term follow-up of pulmonary hypertension (PH) patients and is currently evaluated using the six-minute-walk-test (6MWT). The aim of the study was to assess the convergent validity of the 1-min STST in patients with PH and its association with markers of PH severity.We evaluated 106 PH patients with the 1-min-STST and 6MWT and measured cardiorespiratory parameters (heart rate, blood pressure, oxygen saturation) before and after test conduction. N-terminal pro brain-type natriuretic peptide (NT-proBNP), WHO functional class (WHO-FC) and mean pulmonary artery pressure (mPAP) were defined as markers of PH severity.Strong correlation was found between performances of 1-min STST and 6MWT (r = .711, p < .001), indicating convergent validity. Both tests were inversely associated with NT-proBNP (STST: r = -.405, p < .001; 6MWT: r = -.358, p < .001), WHO-FC (STST: r = -.591, p < .001; 6MWT: r = -.643, p < .001) and mPAP (STST: r = -.280, p < .001; 6MWT: r = -.250, p < .001). Significant changes in cardiorespiratory parameters were observed in both tests (all p < 0.001). Further the post-exercise cardiorespiratory parameters correlated strongly between the 1-min STST and 6MWT (all r ≥ .651, all p < .001).The 1-min STST demonstrated good convergent validity with the 6MWT and was associated with markers of PH severity. Furthermore, both exercise tests caused similar cardiorespiratory responses.
rights: Copyright: © 2023 Kronberger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-22-31968
doi: 10.1371/journal.pone.0282697
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Kronberger C
      type: Person
      first name: Christina
      last name: Kronberger
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 2
    item: Mousavi RA
      type: Person
      first name: Roya Anahita
      last name: Mousavi
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 3
    item: Öztürk B
      type: Person
      first name: Begüm
      last name: Öztürk
      member of: Department of Cardiology, Clinic Favoriten, Vienna, Austria.
  slot:
    index: 4
    item: Willixhofer R
      type: Person
      first name: Robin
      last name: Willixhofer
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 5
    item: Dachs TM
      type: Person
      first name: Theresa-Marie
      last name: Dachs
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 6
    item: Rettl R
      type: Person
      first name: René
      last name: Rettl
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 7
    item: Camuz-Ligios L
      type: Person
      first name: Luciana
      last name: Camuz-Ligios
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 8
    item: Rassoulpour N
      type: Person
      first name: Nima
      last name: Rassoulpour
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 9
    item: Krall C
      type: Person
      first name: Christoph
      last name: Krall
      member of: Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 10
    item: Litschauer B
      type: Person
      first name: Brigitte
      last name: Litschauer
      member of: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 11
    item: Badr Eslam R
      type: Person
      first name: Roza
      last name: Badr Eslam
      member of: Department of Cardiology, Medical University of Vienna, Vienna, Austria.
created: 2023-3-10T06:00
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-3-9T13:43
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 3
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0282697
has place of publication: United States
has primary subject term: D006976Q000175
has subject term: D006801
has subject term: D005080
has subject term: http://id.nlm.nih.gov/mesh/D000070857
has subject term: D001794Q000502
has subject term: D006339Q000502
has subject term: D017079Q000502
source: PLoS One. 2023;18(3):e0282697.
volume: 18

Sex Differences in Cocaine Sensitization Vary by Mouse Strain.
pmid: 37040721
abstract: Preclinical literature, frequently utilizing rats, suggests females display a more rapid advancement of substance abuse and a greater risk of relapse following drug abstinence. In clinical populations, it is less clear as to what extent biological sex is a defining variable in the acquisition and maintenance of substance use. Even without considering environmental experiences, genetic factors are presumed to critically influence the vulnerability to addiction. Genetically diverse mouse models provide a robust tool to examine the interactions between genetic background and sex differences in substance abuse.We explored mouse strain variability in male versus female behavioral sensitization to cocaine. Locomotor sensitization was observed following 5 consecutive days of subcutaneous cocaine across three genetically different mice strains: C57BL/6J, B6129SF2/J, and Diversity Outbred (DO/J).Sex differences in cocaine locomotor sensitization were dependent on mouse strain. Specifically, we observed opposing sex differences in locomotor sensitization, with male C57BL/6J and female B6129SF2/J mice displaying heightened activity compared to their opposite sex counterparts. Conversely, no sex differences were observed in the DO/J mice. Acute cocaine administration resulted in locomotor differences across strains in male, but not female, mice. The magnitude of sensitization (or lack thereof) also varied by genetic background.While sex differences in drug addiction may be observed, these effects can be mitigated, or even reversed, depending on genetic background. The clinical implications are that in the absence of understanding the genetic variables underlying vulnerability to addiction, sex provides little information regarding the predisposition of an individual to drug abuse.
rights: © 2023 S. Karger AG, Basel.
has PII: 000530591
doi: 10.1159/000530591
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Chapp AD
      type: Person
      first name: Andrew D
      last name: Chapp
      member of: Department of Neuroscience and Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota, USA.
  slot:
    index: 2
    item: Nwakama CA
      type: Person
      first name: Chinonso A
      last name: Nwakama
      member of: Department of Neuroscience and Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota, USA.
  slot:
    index: 3
    item: Thomas MJ
      type: Person
      first name: Mark J
      last name: Thomas
      member of: Department of Neuroscience and Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota, USA.
  slot:
    index: 4
    item: Meisel RL
      type: Person
      first name: Robert L
      last name: Meisel
      member of: Department of Neuroscience and Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota, USA.
  slot:
    index: 5
    item: Mermelstein PG
      type: Person
      first name: Paul G
      last name: Mermelstein
      member of: Department of Neuroscience and Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota, USA.
created: 2023-4-12T06:00
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-4-11T18:22
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 11
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1167
ending page: 1176
has place of publication: Switzerland
has primary subject term: D003042Q000494
has primary subject term: D019966
has subject term: D051379
has subject term: D051381
has subject term: D005260
has subject term: D008297
has subject term: D000818
has subject term: D018765Q000494
has subject term: D012727
has subject term: D008810
source: Neuroendocrinology. 2023;113(11):1167-1176.
volume: 113

Estradiol Enhances the Development of Addiction-Like Features in a Female Rat Model of Opioid Use Disorder.
pmid: 36878201
abstract: Women are more vulnerable than men in many aspects of opioid use disorder (OUD); a major theory of sex differences in substance use disorders is that these differences are due to ovarian hormones with estradiol enhancing vulnerability in females. However, most of this evidence is for psychostimulants and alcohol; evidence with opioids is sparse. Thus, the goal of this study was to determine the impact of estradiol on vulnerability in females in a rat model of OUD.Following self-administration training, ovariectomized (OVX) females with (E) or without (V) estradiol replacement were given extended (24 h/day), intermittent access (2, 5-min trials/h) to fentanyl for 10 days. Then, the development of three key features of OUD were assessed, including physical dependence, defined by the magnitude and time course of weight loss during withdrawal; an enhanced motivation for fentanyl, assessed using a progressive-ratio schedule; and relapse vulnerability, assessed using an extinction/cue-induced reinstatement procedure. These later two characteristics were examined following 14 days of withdrawal when the phenotypes are known to be highly expressed.OVX+E females self-administered markedly higher levels of fentanyl under extended, intermittent-access conditions and showed a longer time course of physical dependence, a greater increase in motivation for fentanyl, and an enhanced sensitivity to the reinstating effects of fentanyl-associated cues compared to OVX+V rats. Severe health complications were also observed in OVX+E, but not OVX+V females, during withdrawal.These results indicate that, as with findings with psychostimulants and alcohol, estradiol enhances vulnerability in females to developing opioid addiction-like features and serious opioid-related health complications.
rights: © 2023 S. Karger AG, Basel.
has PII: 000529997
doi: 10.1159/000529997
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Towers EB
      type: Person
      first name: Eleanor Blair
      last name: Towers
      member of: Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA.Medical Scientist Training Program, University of Virginia, Charlottesville, Virginia, USA.
  slot:
    index: 2
    item: Setaro B
      type: Person
      first name: Ben
      last name: Setaro
      member of: Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA.
  slot:
    index: 3
    item: Lynch WJ
      type: Person
      first name: Wendy J
      last name: Lynch
      member of: Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA.
created: 2023-3-7T06:00
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-3-6T18:23
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 11
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1099
ending page: 1111
has place of publication: Switzerland
has primary subject term: D004958Q000494
has primary subject term: D009293
has subject term: D006801
has subject term: D051381
has subject term: D005260
has subject term: D000818
has subject term: D008297
has subject term: D009042
has subject term: D000431
has subject term: D005283
source: Neuroendocrinology. 2023;113(11):1099-1111.
volume: 113

Ex-ante impact of pest des petits ruminant control on micro and macro socioeconomic indicators in Senegal: A system dynamics modelling approach.
pmid: 37405996
abstract: Vaccination is considered as the main tool for the Global Control and Eradication Strategy for peste des petits ruminants (PPR), and the efficacity of the PPR-vaccine in conferring long-life immunity has been established. Despite this, previous studies asserted that vaccination can be expensive and consequently, the effectiveness of disease control may not necessarily translate to overall profit for farmers. Also, the consequences of PPR control on socioeconomic indicators like food and nutrition security at a macro-national level have not been explored thoroughly. Therefore, this study seeks to assess ex-ante the impact of PPR control strategies on farm-level profitability and the socioeconomic consequences concerning food and nutrition security at a national level in Senegal. A bi-level system dynamics model, compartmentalised into five modules consisting of integrated production-epidemiological, economics, disease control, marketing, and policy modules, was developed with the STELLA Architect software, validated, and simulated for 30 years at a weekly timestep. The model was parameterised with data from household surveys from pastoral areas in Northern Senegal and relevant existing data. Nine vaccination scenarios were examined considering different vaccination parameters (vaccination coverage, vaccine wastage, and the provision of government subsidies). The findings indicate that compared to a no-vaccination scenario, all the vaccination scenarios for both 26.5% (actual vaccination coverage) and 70% (expected vaccination coverage) resulted in statistically significant differences in the gross margin earnings and the potential per capita consumption for the supply of mutton and goat meat. At the prevailing vaccination coverage (with or without the provision of government subsidies), farm households will earn an average gross margin of $69.43 (annually) more than without vaccination, and the average per capita consumption for mutton and goat meat will increase by [cell cut: 2654 characters, first 2000 kept]
rights: Copyright: © 2023 Aboah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-23-09433
doi: 10.1371/journal.pone.0287386
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Aboah J
      type: Person
      first name: Joshua
      last name: Aboah
      member of: International Livestock Research Institute, West Africa Regional Office, Dakar, Senegal.Commonwealth Scientific and Industrial Research Organisation, Agriculture & Food Business Unit, Brisbane, Australia.
  slot:
    index: 2
    item: Apolloni A
      type: Person
      first name: Andrea
      last name: Apolloni
      member of: CIRAD, UMR ASTRE Montpellier, Montpellier, France.
  slot:
    index: 3
    item: Duboz R
      type: Person
      first name: Raphaël
      last name: Duboz
      member of: CIRAD, UMR ASTRE Montpellier, Montpellier, France.
  slot:
    index: 4
    item: Wieland B
      type: Person
      first name: Barbara
      last name: Wieland
      member of: Institute of Virology and Immunology, Mittelhäusern, Switzerland.Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
  slot:
    index: 5
    item: Kotchofa P
      type: Person
      first name: Pacem
      last name: Kotchofa
      member of: International Water Management Institute, C/o ILRI 2R87+GPC, Addis Ababa, Ethiopia.
  slot:
    index: 6
    item: Okoth E
      type: Person
      first name: Edward
      last name: Okoth
      member of: International Livestock Research Institute, West Africa Regional Office, Dakar, Senegal.
  slot:
    index: 7
    item: Dione M
      type: Person
      first name: Michel
      last name: Dione
      member of: International Livestock Research Institute, West Africa Regional Office, Dakar, Senegal.
created: 2023-7-5T19:12
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-7-5T13:33
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 7
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0287386
has place of publication: United States
has primary subject term: D015511Q000517
has primary subject term: D029021Q000517
has primary subject term: D018107
has subject term: D000818
has subject term: D012675
has subject term: D006041
has subject term: D007182
source: PLoS One. 2023;18(7):e0287386.
volume: 18

The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling.
pmid: 37258578
abstract: The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) promotes lung tumorigenesis through deregulation of the pulmonary RA system. Mechanistically, NNK binding to the nicotinic acetylcholine receptor (nAChR) induces Src-mediated signal transducer and activator of transcription 3 (STAT3) activation, resulting in transcriptional upregulation of angiotensinogen (AGT) and subsequent induction of the angiotensin II (AngII) receptor type 1 (AGTR1) signaling pathway. In parallel, NNK concurrently increases insulin-like growth factor 2 (IGF2) production and activation of IGF-1R/insulin receptor (IR) signaling via a two-step pathway involving transcriptional upregulation of IGF2 through STAT3 activation and enhanced secretion from intracellular storage through AngII/AGTR1/PLC-intervened calcium release. NNK-mediated crosstalk between IGF-1R/IR and AGTR1 signaling promoted tumorigenic activity in lung epithelial and stromal cells. Lung tumorigenesis caused by NNK exposure or alveolar type 2 cell-specific Src activation was suppressed by heterozygous Agt knockout or clinically available inhibitors of the nAChR/Src or AngII/AGTR1 pathways. These results demonstrate that NNK-induced stimulation of the lung RA system leads to IGF2-mediated IGF-1R/IR signaling activation in lung epithelial and stromal cells, resulting in lung tumorigenesis in smokers.
rights: © 2023. The Author(s).
has PII: 10.1038/s12276-023-00994-2
doi: 10.1038/s12276-023-00994-2
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Boo HJ
      type: Person
      first name: Hye-Jin
      last name: Boo
      member of: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.Department of Histology, College of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
  slot:
    index: 2
    item: Min HY
      type: Person
      first name: Hye-Young
      last name: Min
      member of: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
  slot:
    index: 3
    item: Hwang SJ
      type: Person
      first name: Su Jung
      last name: Hwang
      member of: School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  slot:
    index: 4
    item: Lee HJ
      type: Person
      first name: Hyo-Jong
      last name: Lee
      member of: School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
  slot:
    index: 5
    item: Lee JW
      type: Person
      first name: Jae-Won
      last name: Lee
      member of: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju-si, Chungcheongbuk-do, 28116, Republic of Korea.
  slot:
    index: 6
    item: Oh SR
      type: Person
      first name: Sei-Ryang
      last name: Oh
      member of: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju-si, Chungcheongbuk-do, 28116, Republic of Korea.
  slot:
    index: 7
    item: Park CS
      type: Person
      first name: Choon-Sik
      last name: Park
      member of: Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
  slot:
    index: 8
    item: Park JS
      type: Person
      first name: Jong-Sook
      last name: Park
      member of: Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, 14584, Republic of Korea.
  slot:
    index: 9
    item: Lee YM
      type: Person
      first name: You Mie
      last name: Lee
      member of: Vessel-Organ Interaction Research Center (VOICE, MRC), College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea.
  slot:
    index: 10
    item: Lee HY
      type: Person
      first name: Ho-Young
      last name: Lee
      member of: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea. hylee135@snu.ac.kr.
created: 2023-6-1T01:08
date last updated: 2025-01-17
issued: 2023-06
dp: 2023 06
created: 2023-5-31T23:19
e ISSN: 2092-6413
has issn l: 1226-3613
issue: 6
has NLM journal title abbreviation: Exp Mol Med
publication name: Experimental & molecular medicine
language: eng
has national library of medicine journal id: 9607880
derived from: NLM
starting page: 1131
ending page: 1144
has place of publication: United States
has primary subject term: D009602Q000633Q000378
has primary subject term: D011978Q000378
has primary subject term: D008175Q000139Q000235Q000378
has subject term: D002273Q000633
has subject term: D012084
has subject term: D050796Q000378
has subject term: D015398
has subject term: D008168Q000378
has subject term: D063646
source: Exp Mol Med. 2023-06;55(6):1131-1144.
volume: 55

Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation.
pmid: 37535643
abstract: The objective of our study was to assess the effect of rumen-protected niacin supplementation on the transcriptome of liver tissue in growing Angus × Simmental steers and heifers through RNA-seq analysis. Consequently, we wanted to assess the known role of niacin in the physiological processes of vasodilation, detoxification, and immune function in beef hepatic tissue. Normal weaned calves (~8 months old) were provided either a control diet or a diet supplemented with rumen-protected niacin (6 g/hd/d) for a 30-day period, followed by a liver biopsy. We observed a significant list of changes at the transcriptome level due to rumen-protected niacin supplementation. Several metabolic pathways revealed potential positive effects to the animal's liver metabolism due to administration of rumen-protected niacin; for example, a decrease in lipolysis, apoptosis, inflammatory responses, atherosclerosis, oxidative stress, fibrosis, and vasodilation-related pathways. Therefore, results from our study showed that the liver transcriptional machinery switched several metabolic pathways to a condition that could potentially benefit the health status of animals supplemented with rumen-protected niacin. In conclusion, based on the results of our study, we can suggest the utilization of rumen-protected niacin supplementation as a nutritional strategy could improve the health status of growing beef cattle in different beef production stages, such as backgrounding operations or new arrivals to a feedlot.
rights: Copyright: © 2023 Alfaro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-22-33044
doi: 10.1371/journal.pone.0289409
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Alfaro GF
      type: Person
      first name: Gastón F
      last name: Alfaro
      member of: Department of Animal Sciences, Auburn University, Auburn, AL, United States of America.
  slot:
    index: 2
    item: Palombo V
      type: Person
      first name: Valentino
      last name: Palombo
      member of: Department of Agricultural, Environmental and Food Sciences, Università degli Studi del Molise, Campobasso, Italy.
  slot:
    index: 3
    item: D'Andrea M
      type: Person
      first name: Mariasilvia
      last name: D'Andrea
      member of: Department of Agricultural, Environmental and Food Sciences, Università degli Studi del Molise, Campobasso, Italy.
  slot:
    index: 4
    item: Cao W
      type: Person
      first name: Wenqi
      last name: Cao
      member of: Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America.
  slot:
    index: 5
    item: Zhang Y
      type: Person
      first name: Yue
      last name: Zhang
      member of: Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America.
  slot:
    index: 6
    item: Beever J
      type: Person
      first name: Jonathan
      last name: Beever
      member of: Department of Animal Sciences, University of Tennessee, Knoxville, TN, United States of America.
  slot:
    index: 7
    item: Muntifering RB
      type: Person
      first name: Russell B
      last name: Muntifering
      member of: Department of Animal Sciences, Auburn University, Auburn, AL, United States of America.Cooperative Extension Service, University of Kentucky, Kentucky, Lexington, United States of America.
  slot:
    index: 8
    item: Pacheco WJ
      type: Person
      first name: Wilmer J
      last name: Pacheco
      member of: Department of Poultry Sciences, Auburn University, Auburn, AL, United States of America.
  slot:
    index: 9
    item: Rodning SP
      type: Person
      first name: Soren P
      last name: Rodning
      member of: Department of Animal Sciences, Auburn University, Auburn, AL, United States of America.
  slot:
    index: 10
    item: Wang X
      type: Person
      first name: Xu
      last name: Wang
      member of: Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America.HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States of America.
  slot:
    index: 11
    item: Moisá SJ
      type: Person
      first name: Sonia J
      last name: Moisá
      member of: Department of Animal Sciences, University of Tennessee, Knoxville, TN, United States of America.
created: 2023-8-3T19:14
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-8-3T13:44
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 8
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0289409
has place of publication: United States
has primary subject term: D009525Q000494Q000378
has subject term: D002417
has subject term: D000818
has subject term: D005260
has subject term: D012417Q000378
has subject term: D019587
has subject term: D004032Q000662
has subject term: D008099
has subject term: D000821Q000032
source: PLoS One. 2023;18(8):e0289409.
volume: 18

Retaliation of Alstonia scholaris (L.) R.Br. to caesium and strontium in hydroponics: effect on morpho-physiology and induction of enzymatic defence.
pmid: 37212912
abstract: The habitation and environment are affected by the stable isotopes of caesium (Cs) and strontium (Sr), as well as by their radioactive isotopes. The current work gives insight on Alstonia scholaris' capacity to phytoextract stable caesium (Cs) and strontium (Sr), as well as the plant's ability to protect against the toxicity of both elements. Experiments with Cs [0-5 mM (CsCl)] and Sr [0-3 mM (SrCl2. 6H2O)] dosing in controlled light, temperature, and humidity condition in greenhouse for 21 days were undertaken. Cs and Sr accumulation in different plant parts was quantified with atomic absorption spectroscopy (AAS) and inductively coupled plasma-optical emission spectrometry (ICP-OES) respectively. Hyper-accumulation capacity for Cs and Sr was estimated with indices like transfer factor (TF) and translocation factors (TrF). The uptake pattern of caesium in Alstonia scholaris is 5452.8-24,771.4 mg/kg DW (TF = 85.2-57.6) and in the case of Sr is 1307.4-8705.7 mg/kg DW (TF = 85.3-1.46). The findings demonstrated the plant's ability to transfer Cs and Sr to aboveground biomass on the basis of dry weight, with the majority of the metals being deposited in the shoot rather than the root portion of the plant. For Cs and Sr, with increasing concentration, the plants exhibited the enzymatic expression for defence against metal toxicity by free radicals compared to control. Field emission electron microscopy with energy-dispersive spectroscopy (FESEM with EDS) was employed to assess the spatial distribution of Cs and Sr in plant leaf, indicating the accumulation of Cs, Sr, and their homologous components.
rights: © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
has PII: 10.1007/s10661-023-11304-8
doi: 10.1007/s10661-023-11304-8
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Singh BSM
      type: Person
      first name: B S Manisha
      last name: Singh
      member of: Environment and Sustainability Department, CSIR-IMMT, Bhubaneshwar, 751013, India. bsmanishasingh@gmail.com.Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. bsmanishasingh@gmail.com.
  slot:
    index: 2
    item: Dhal NK
      type: Person
      first name: Nabin Kumar
      last name: Dhal
      member of: Environment and Sustainability Department, CSIR-IMMT, Bhubaneshwar, 751013, India.
  slot:
    index: 3
    item: Kumar M
      type: Person
      first name: Manish
      last name: Kumar
      member of: Environment and Sustainability Department, CSIR-IMMT, Bhubaneshwar, 751013, India.
  slot:
    index: 4
    item: Mohapatra D
      type: Person
      first name: Dinakrushna
      last name: Mohapatra
      member of: Safety Research Institute, AERB, Kalpakkam, 603102, India.
  slot:
    index: 5
    item: Seshadri H
      type: Person
      first name: Hariharan
      last name: Seshadri
      member of: Safety Research Institute, AERB, Kalpakkam, 603102, India.
  slot:
    index: 6
    item: Nayak M
      type: Person
      first name: Monalisha
      last name: Nayak
      member of: Atomic Energy Regulatory Board, Niyamak Bhavan, Anushakti Nagar, Mumbai, 400094, India.
created: 2023-5-22T13:04
date last updated: 2025-01-17
issued: 2023-05-22
dp: 2023 May 22
created: 2023-5-22T11:07
e ISSN: 1573-2959
has issn l: 0167-6369
issue: 6
has NLM journal title abbreviation: Environ Monit Assess
publication name: Environmental monitoring and assessment
language: eng
has national library of medicine journal id: 8508350
derived from: NLM
pg: 703
has place of publication: Netherlands
has primary subject term: D013324Q000633
has primary subject term: D031051Q000378
has subject term: D018527
has subject term: D004784
has subject term: D002586Q000378
has subject term: D013326
source: Environ Monit Assess. 2023-05-22;195(6):703.
volume: 195

Fascinating Pathway to Facilitate the Photoisomerization of Spiropyran-Based Nanocomposites.
pmid: 37578118
abstract: Recently, spiropyran-based composites have gained more attention on account of their stimuli-responsive essence, especially of the fascinating and green photo stimulus. However, the great dipole moment change between the ring-opened merocyanine and ring-closed spiropyran requires a large free volume available for isomerization, which significantly restrains the photoisomerization of spiropyran-based nanocomposites. Herein, a fascinating pathway by regulating the states both of spiropyran and the immobilized nanoparticle supports was put forward to facilitate the photoisomerization. The results demonstrated that the spiropyran grafting percentage of 5.18% and immobilized supports with less aggregation, high specific surface area, large pore size, and noncrystalline structure were suitable to fabricate spiropyran-based nanocomposites, which showed a significant improvement for Pb2+ and Cr3+ removal from aqueous solution on account of free photoisomerization of spiropyran on the support's surface. This work will pave the pathway to extend the exploitation of spiropyran-based nanocomposites in various fields such as biotechnology, physiology, and electronics to photonics and environmental-friendly fields.
doi: 10.1021/acsami.3c06774
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Guan X
      type: Person
      first name: Xiaoyu
      last name: Guan
      member of: College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China.Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako 351-0198, Saitama, Japan.Key Laboratory of Leather Chemistry and Engineering (Sichuan University), Ministry of Education, Chengdu 610065, PR China.
  slot:
    index: 2
    item: Zhang B
      type: Person
      first name: Bingyuan
      last name: Zhang
      member of: College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China.
  slot:
    index: 3
    item: Zhu Y
      type: Person
      first name: Yanxia
      last name: Zhu
      member of: College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China.
  slot:
    index: 4
    item: Zheng S
      type: Person
      first name: Sai
      last name: Zheng
      member of: College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China.
  slot:
    index: 5
    item: Li D
      type: Person
      first name: Dongping
      last name: Li
      member of: College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China.
  slot:
    index: 6
    item: Liu S
      type: Person
      first name: Shiyong
      last name: Liu
      member of: Chengdu Decoli Polymer Materials Corporation Limited, Chengdu 610065, PR China.
  slot:
    index: 7
    item: Han Q
      type: Person
      first name: Qingxin
      last name: Han
      member of: College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China.
created: 2023-8-14T12:42
date last updated: 2025-01-17
issued: 2023-08-23
dp: 2023 Aug 23
created: 2023-8-14T07:43
e ISSN: 1944-8252
has issn l: 1944-8244
issue: 33
has NLM journal title abbreviation: ACS Appl Mater Interfaces
publication name: ACS applied materials & interfaces
language: eng
has national library of medicine journal id: 101504991
derived from: NLM
starting page: 39827
ending page: 39836
has place of publication: United States
source: ACS Appl Mater Interfaces. 2023-08-23;15(33):39827-39836.
volume: 15

Diversity of lithophytic moss species in karst regions in response to elevation gradients.
pmid: 37390100
abstract: The distribution pattern of species diversity along various elevation gradients reflects the biological and ecological characteristics of species, distribution status and adaptability to the environment. Altitude, a comprehensive ecological factor, affects the spatial distribution of species diversity in plant communities by causing integrated changes in light, temperature, water and soil factors. In Guiyang City, we studied the species diversity of lithophytic mosses and the relationships between species and environmental factors. The results showed that: (1) There were 52 species of bryophytes in 26 genera and 13 families within the study area. The dominant families were Brachytheciaceae, Hypnaceae and Thuidiaceae. The dominant genera were Brachythecium, Hypnum, Eurhynchium, Thuidium, Anomodon and Plagiomnium; The dominant species were Eurohypnum leptothallum, Brachythecium salebrosum, Brachythecium pendulum etc. The number of family species and dominant family genera increased first and then decreased with the increase of altitude, and their distribution in elevation gradient III (1334-1515m) was the largest, with 8 families, 13 genera and 21 species. The elevation gradient I (970-1151m) was the least species distributed, with 5 families, 10 genera and 14 species. The dominant species with the largest number in each elevational gradient were Eurohypnum leptothallum, Brachythecium pendulum, Brachythecium salebrosum and Entodon prorepens; (2) There were five kinds of life forms in different elevation gradients, including Wefts, Turfs, Mat, Pendants and Tail. Among them, wefts and turfs appeared in all elevations, while a small amount of Pendants appeared in the area of elevational gradient I (970-1151m), and the most abundant life form was found in the range of elevational gradient III (1334-1515m); (3) Patrick richness index and Shannon-Wiener diversity index were highly significantly (p<0.01) positively correlated, both of which increased and then decreased with [cell cut: 3004 characters, first 2000 kept]
rights: Copyright: © 2023 Jin, Wang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-22-35414
doi: 10.1371/journal.pone.0286722
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Jin Y
      type: Person
      first name: Yalin
      last name: Jin
      member of: College of Forestry, Guizhou University, Guiyang, Guizhou, China.
  slot:
    index: 2
    item: Wang X
      type: Person
      first name: Xiurong
      last name: Wang
      member of: College of Forestry, Guizhou University, Guiyang, Guizhou, China.
created: 2023-6-30T19:14
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-6-30T13:35
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 6
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0286722
has place of publication: United States
has primary subject term: D044002
has primary subject term: D019068
has subject term: D006801
has subject term: D002681
has subject term: D000531
has subject term: D044822
source: PLoS One. 2023;18(6):e0286722.
volume: 18

Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and across the Estrous Cycle.
pmid: 37271140
abstract: Sex and ovarian hormones influence cocaine seeking and relapse vulnerability, but less is known regarding the cellular and synaptic mechanisms contributing to these behavioral sex differences. One factor thought to influence cue-induced seeking behavior following withdrawal is cocaine-induced changes in the spontaneous activity of pyramidal neurons in the basolateral amygdala (BLA). However, the mechanisms underlying these changes, including potential sex or estrous cycle effects, are unknown.Ex vivo whole-cell patch clamp electrophysiology was conducted to investigate the effects of cocaine exposure, sex, and estrous cycle fluctuations on two properties that can influence spontaneous activity of BLA pyramidal neurons: (1) frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) and (2) intrinsic excitability. Recordings of BLA pyramidal neurons were conducted in adult male and female rats and across the estrous cycle following 2-4 weeks of withdrawal from extended-access cocaine self-administration (6 h/day for 10 days) or drug-naïve conditions.In both sexes, cocaine exposure increased the frequency, but not amplitude, of sEPSCs and neuronal intrinsic excitability. Across the estrous cycle, sEPSC frequency and intrinsic excitability were significantly elevated only in cocaine-exposed females in the estrus stage of the cycle, a stage when cocaine-seeking behavior is known to be enhanced.Here, we identify potential mechanisms underlying cocaine-induced alterations in the spontaneous activity of BLA pyramidal neurons in both sexes along with changes in these properties across the estrous cycle.
rights: © 2023 The Author(s). Published by S. Karger AG, Basel.
has PII: 000531351
doi: 10.1159/000531351
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Corbett CM
      type: Person
      first name: Claire M
      last name: Corbett
      member of: Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
  slot:
    index: 2
    item: Miller END
      type: Person
      first name: Emily N D
      last name: Miller
      member of: Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
  slot:
    index: 3
    item: Wannen EE
      type: Person
      first name: Erin E
      last name: Wannen
      member of: Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
  slot:
    index: 4
    item: Rood BD
      type: Person
      first name: Benjamin D
      last name: Rood
      member of: Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
  slot:
    index: 5
    item: Chandler DJ
      type: Person
      first name: Daniel J
      last name: Chandler
      member of: Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
  slot:
    index: 6
    item: Loweth JA
      type: Person
      first name: Jessica A
      last name: Loweth
      member of: Graduate School of Biomedical Sciences, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
created: 2023-6-5T00:41
date last updated: 2025-01-17
issued: 2023
dp: 2023
created: 2023-6-4T18:23
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 11
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1127
ending page: 1139
has place of publication: Switzerland
has primary subject term: D066272
has primary subject term: D003042Q000494
has subject term: D051381
has subject term: D000818
has subject term: D005260
has subject term: D008297
has subject term: D017207
has subject term: D009435
has subject term: D030762
source: Neuroendocrinology. 2023;113(11):1127-1139.
volume: 113

Bibliometric Analysis of Global Research on Circular RNA: Current Status and Future Directions.
pmid: 37587318
abstract: Circular RNAs (circRNAs) have gained significant attention in recent years. This bibliometric analysis aimed to provide insights into the current state and future trends of global circRNA research. The scientific output on circRNAs from 2010 to 2022 was retrieved from the Web of Science Core Collection with circRNA-related terms as the subjects. Key bibliometric indicators were calculated and evaluated using CiteSpace. A total of 7385 studies on circRNAs were identified. The output and citation number have increased rapidly after 2015. China, the USA, and Germany were top three publishing countries. Currently, circCDR1as, circHIPK3, circPVT1, circSHPRH, and circZNF609 are the most studied circRNAs; and all are related to cancer. The theme of research have shifted from transcript, exon circularization and miRNA sponge topics to the transcriptome, tumor suppressor, and biomarkers, indicating that research interests have evolved from basic to applied research. CircRNAs will continue to be a highly active research area in the near future. From the current understanding of circRNA characterization and regulatory mechanisms as miRNA sponges in cancer, future directions may examine potential diagnostic and therapeutic roles of circRNAs in cancers or the function and mechanism of circRNAs in other diseases.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12033-023-00830-y
doi: 10.1007/s12033-023-00830-y
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Yehui L
      type: Person
      first name: Lv
      last name: Yehui
      member of: Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai, China.Department of Human Anatomy and Histology, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.
  slot:
    index: 2
    item: Zhihong L
      type: Person
      first name: Li
      last name: Zhihong
      member of: Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai, China.Department of Human Anatomy and Histology, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.
  slot:
    index: 3
    item: Fang T
      type: Person
      first name: Tong
      last name: Fang
      member of: Department of Human Anatomy and Histology, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.Department of Physiology and Biochemistry, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.
  slot:
    index: 4
    item: Zixuan Z
      type: Person
      first name: Zeng
      last name: Zixuan
      member of: Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai, China.
  slot:
    index: 5
    item: Mengyuan Z
      type: Person
      first name: Zhang
      last name: Mengyuan
      member of: Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai, China.
  slot:
    index: 6
    item: Zhifang Y
      type: Person
      first name: Yang
      last name: Zhifang
      member of: Department of Human Anatomy and Histology, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.Department of Physiology and Biochemistry, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China.
  slot:
    index: 7
    item: Jiuhong Z
      type: Person
      first name: Zhao
      last name: Jiuhong
      member of: Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai, China. zhaojh@sumhs.edu.cn.Department of Human Anatomy and Histology, School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China. zhaojh@sumhs.edu.cn.
created: 2023-8-17T00:41
date last updated: 2025-01-17
issued: 2024-08
dp: 2024 Aug
created: 2023-8-16T23:32
e ISSN: 1559-0305
has issn l: 1073-6085
issue: 8
has NLM journal title abbreviation: Mol Biotechnol
publication name: Molecular biotechnology
language: eng
has national library of medicine journal id: 9423533
derived from: NLM
starting page: 2064
ending page: 2077
has place of publication: Switzerland
has primary subject term: D000079962Q000235
has primary subject term: D015706
has primary subject term: D009369Q000235
has subject term: D006801
has subject term: D035683Q000235
source: Mol Biotechnol. 2024-08;66(8):2064-2077.
volume: 66

Learning needs in healthy and active aging according to key stakeholders: A multinational survey.
pmid: 37647110
abstract: Healthy and active aging and age-friendly society frameworks attempt to address the well-documented challenges and opportunities of population aging. To meet the needs of an increasingly older society, there is a demand for professionals with appropriate age-related knowledge and skills. To this end, a master's in active aging is in development. This study reports on the consultation with prospective students, employers, older people and academics on the knowledge areas to be included in the course. An anonymous online survey gathered data from stakeholders in Ireland, Slovenia, Austria, Portugal, Finland, and Greece. Participants ranked the importance of 14 broad knowledge areas and linked topics. The influence of participant characteristics on decisions was examined using multivariate regression modeling. Across all stakeholder groups (total sample N = 757), health promotion was most often deemed very important (80%), followed by psychology (73%), and social inclusion and engagement (71%). Potential students from healthcare backgrounds were more interested than others in aging physiology, social aspects, and the physical environment. More western-located European countries overall showed more enthusiasm for the topics presented, additional to regional variations between topics. This learning needs analysis provides multi-stakeholder insights into priorities regarding learning in healthy and active aging and age-friendly society.
doi: 10.1080/02701960.2023.2252368
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Wiggin DA
      type: Person
      first name: Daisy A
      last name: Wiggin
      member of: Centre for Gerontology and Rehabilitation, School of Medicine, University College Cork, Cork, Ireland.
  slot:
    index: 2
    item: Setti A
      type: Person
      first name: Annalisa
      last name: Setti
      member of: School of Applied Psychology, University College Cork, Cork, Ireland.
  slot:
    index: 3
    item: Mali J
      type: Person
      first name: Jana
      last name: Mali
      member of: Faculty of Social Work, University of Ljubljana, Ljubljana, Slovenia.
  slot:
    index: 4
    item: Ströckl DE
      type: Person
      first name: Daniela Elisabeth
      last name: Ströckl
      member of: Institute for Applied Research on Ageing, Dep. Health and Assistive Technologies, School of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, Austria.
  slot:
    index: 5
    item: Sourtzi P
      type: Person
      first name: Panayota
      last name: Sourtzi
      member of: Department of Nursing, Laboratory of Prevention, National and Kapodistrian University of Athens, Athens, Greece.
  slot:
    index: 6
    item: Nevala E
      type: Person
      first name: Elina
      last name: Nevala
      member of: Karelia University of Applied Sciences, Joensuu, Finland.
  slot:
    index: 7
    item: Penič B
      type: Person
      first name: Benjamin
      last name: Penič
      member of: Faculty of Social Work, University of Ljubljana, Ljubljana, Slovenia.
  slot:
    index: 8
    item: Zymbal V
      type: Person
      first name: Vera
      last name: Zymbal
      member of: CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
  slot:
    index: 9
    item: Cardadeiro G
      type: Person
      first name: Graça
      last name: Cardadeiro
      member of: CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
  slot:
    index: 10
    item: Carnide F
      type: Person
      first name: Filomena
      last name: Carnide
      member of: CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
  slot:
    index: 11
    item: Baptista F
      type: Person
      first name: Fátima
      last name: Baptista
      member of: CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal.
  slot:
    index: 12
    item: Fitzgerald T
      type: Person
      first name: Tony
      last name: Fitzgerald
      member of: School of Public Health, University College Cork, Cork, Ireland.Department of Statistics, School of Mathematical Science, University College Cork, Cork, Ireland.
  slot:
    index: 13
    item: Timmons S
      type: Person
      first name: Suzanne
      last name: Timmons
      member of: Centre for Gerontology and Rehabilitation, School of Medicine, University College Cork, Cork, Ireland.
created: 2023-8-30T12:43
date last updated: 2025-01-17
created: 2023-8-30T11:53
e ISSN: 1545-3847
has issn l: 0270-1960
issue: 4
has NLM journal title abbreviation: Gerontol Geriatr Educ
publication name: Gerontology & geriatrics education
language: eng
has national library of medicine journal id: 8101294
derived from: NLM
starting page: 584
ending page: 600
has place of publication: England
has primary subject term: D000375Q000523
has primary subject term: D005853Q000193
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000073656
has subject term: D003479
has subject term: D004500
has subject term: http://id.nlm.nih.gov/mesh/D000073597
has subject term: D020380
has subject term: D008297
has subject term: D005260
has subject term: D000328
has subject term: D008875
has subject term: D000368
has subject term: D000369
has subject term: D011795
source: Gerontol Geriatr Educ. ;45(4):584-600.
volume: 45

The HOPE Asia Network consensus on blood pressure measurements corresponding to office measurements: Automated office, home, and ambulatory blood pressures.
pmid: 37878534
abstract: For adopting recently introduced hypertension phenotypes categorized using office and out of office blood pressure (BP) for the diagnosis of hypertension and antihypertension drug therapy, it is mandatory to define the corresponding out of office BP with the specific target BP recommended by the major guidelines. Such conditions include white-coat hypertension (WCH), masked hypertension (MH), white-coat uncontrolled hypertension (WUCH), and masked uncontrolled hypertension (MUCH). Here, the authors review the relevant literature and discuss the related issue to facilitate the use of corresponding BPs for proper diagnosis of WCH, MH, WUCH, and MUCH in the setting of standard target BP as well as intensive target BP. The methodology of deriving the corresponding BP has evolved from statistical methods such as standard deviation, percentile value, and regression to an outcome-based approach using pooled international cohort study data and comparative analysis in randomized clinical trials for target BPs such as the SPRINT and STEP studies. Corresponding BPs to 140/90 and 130/80 mm Hg in office BP is important for safe and strict achievement of intensive BP targets. The corresponding home, daytime, and 24-h BPs to 130/80 mm Hg in office BP are 130/80, 130/80, and 125/75 mm Hg, respectively. However, researchers have found some discrepancies among the home corresponding BPs. As tentative criterion for de-escalation of antihypertensive therapy as shown in European guidelines was 120 mm Hg in office BP, corresponding home, daytime, and 24-h systolic BPs to 120 mm Hg in office systolic BP are 120, 120, and 115 mm Hg, respectively.
rights: © 2023 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
doi: 10.1111/jch.14729
creator: OrderedList
  length: 25
  slot:
    index: 1
    item: Shin J
      type: Person
      first name: Jinho
      last name: Shin
      member of: Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.
  slot:
    index: 2
    item: Wang JG
      type: Person
      first name: Ji-Guang
      last name: Wang
      member of: Department of Cardiovascular Medicine, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  slot:
    index: 3
    item: Chia YC
      type: Person
      first name: Yook-Chin
      last name: Chia
      member of: Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Selangor Darul Ehsan, Malaysia.Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  slot:
    index: 4
    item: Kario K
      type: Person
      first name: Kazuomi
      last name: Kario
      member of: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
  slot:
    index: 5
    item: Chen CH
      type: Person
      first name: Chen-Huan
      last name: Chen
      member of: Department of Medicine, National Yang-Ming Chiao Tung University College of Medicine, Taipei, Taiwan.
  slot:
    index: 6
    item: Cheng HM
      type: Person
      first name: Hao-Min
      last name: Cheng
      member of: Department of Medicine, National Yang-Ming Chiao Tung University College of Medicine, Taipei, Taiwan.
  slot:
    index: 7
    item: Fujiwara T
      type: Person
      first name: Takeshi
      last name: Fujiwara
      member of: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
  slot:
    index: 8
    item: Hoshide S
      type: Person
      first name: Satoshi
      last name: Hoshide
      member of: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
  slot:
    index: 9
    item: Huynh MV
      type: Person
      first name: Minh Van
      last name: Huynh
      member of: Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, ., Vietnam.
  slot:
    index: 10
    item: Li Y
      type: Person
      first name: Yan
      last name: Li
      member of: Department of Cardiovascular Medicine, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  slot:
    index: 11
    item: Nagai M
      type: Person
      first name: Michiaki
      last name: Nagai
      member of: Department of Internal Medicine, General Medicine and Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan.
  slot:
    index: 12
    item: Nailes J
      type: Person
      first name: Jennifer
      last name: Nailes
      member of: University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines.
  slot:
    index: 13
    item: Park S
      type: Person
      first name: Sungha
      last name: Park
      member of: Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea.
  slot:
    index: 14
    item: Siddique S
      type: Person
      first name: Saulat
      last name: Siddique
      member of: Punjab Medical Center, Lahore, Pakistan.
  slot:
    index: 15
    item: Sison J
      type: Person
      first name: Jorge
      last name: Sison
      member of: Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines.
  slot:
    index: 16
    item: Soenarta AA
      type: Person
      first name: Arieska Ann
      last name: Soenarta
      member of: Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia.
  slot:
    index: 17
    item: Sogunuru GP
      type: Person
      first name: Guru Prasad
      last name: Sogunuru
      member of: Fortis Hospitals, Chennai, Tamil Nadu, India.College of Medical Sciences, Kathmandu University, Bharatpur, Nepal.
  slot:
    index: 18
    item: Tay JC
      type: Person
      first name: Jam Chin
      last name: Tay
      member of: Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
  slot:
    index: 19
    item: Teo BW
      type: Person
      first name: Boon Wee
      last name: Teo
      member of: Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore.
  slot:
    index: 20
    item: Tomitani N
      type: Person
      first name: Naoko
      last name: Tomitani
      member of: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
  slot:
    index: 21
    item: Tsoi K
      type: Person
      first name: Kelvin
      last name: Tsoi
      member of: JC School of Public Health and Primary Care, JC Institute of Ageing, SH Big Data Decision Analytics Research Centre, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
  slot:
    index: 22
    item: Turana Y
      type: Person
      first name: Yuda
      last name: Turana
      member of: Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
  slot:
    index: 23
    item: Verma N
      type: Person
      first name: Narsingh
      last name: Verma
      member of: Indian Society of Hypertension, King George's Medical University, Lucknow, Uttar Pradesh, India.
  slot:
    index: 24
    item: Wang TD
      type: Person
      first name: Tzung-Dau
      last name: Wang
      member of: Department of Internal Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan.
  slot:
    index: 25
    item: Zhang Y
      type: Person
      first name: Yuqing
      last name: Zhang
      member of: Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
created: 2023-10-25T18:42
date last updated: 2025-01-17
issued: 2024-12
dp: 2024 Dec
created: 2023-10-25T13:13
e ISSN: 1751-7176
has issn l: 1524-6175
issue: 12
has NLM journal title abbreviation: J Clin Hypertens (Greenwich)
publication name: Journal of clinical hypertension (Greenwich, Conn.)
language: eng
has national library of medicine journal id: 100888554
derived from: NLM
starting page: 1351
ending page: 1361
has place of publication: United States
has primary subject term: D018660Q000379Q000592
has primary subject term: D006973Q000175Q000188Q000503
has primary subject term: D059466Q000175Q000503
has primary subject term: D001794Q000502Q000187
has primary subject term: D001795Q000379
has subject term: D006801
has subject term: D059468Q000175Q000503Q000188
has subject term: D009819Q000706
has subject term: D000959Q000627
has subject term: D001208Q000453
has subject term: D032921
has subject term: D017410
source: J Clin Hypertens (Greenwich). 2024-12;26(12):1351-1361.
volume: 26

Machine learning and decision making in aortic arch repair.
pmid: 38016622
abstract: Decision making during aortic arch surgery regarding cannulation strategy and nadir temperature are important in reducing risk, and there is a need to determine the best individualized strategy in a data-driven fashion. Using machine learning (ML), we modeled the risk of death or stroke in elective aortic arch surgery based on patient characteristics and intraoperative decisions.The study cohort comprised 1323 patients from 9 institutions who underwent an elective aortic arch procedure between 2002 and 2021. A total of 69 variables were used in developing a logistic regression and XGBoost ML model trained for binary classification of mortality and stroke. Shapely additive explanations (SHAP) values were studied to determine the importance of intraoperative decisions.During the study period, 3.9% of patients died and 5.4% experienced stroke. XGBoost (area under the curve [AUC], 0.77 for death, 0.87 for stroke) demonstrated better discrimination than logistic regression (AUC, 0.65 for death, 0.75 for stroke). From SHAP analysis, intraoperative decisions are 3 of the top 20 predictors of death and 6 of the top 20 predictors of stroke. Predictor weights are patient-specific and reflect the patient's preoperative characteristics and other intraoperative decisions. Patient-level simulation also demonstrates the variable contribution of each decision in the context of the other choices that are made.Using ML, we can more accurately identify patients at risk of death and stroke, as well as the strategy that better reduces the risk of adverse events compared to traditional prediction models. Operative decisions made may be tailored based on a patient's specific characteristics, allowing for maximized, personalized benefit.
rights: Copyright © 2023 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
has PII: S0022-5223(23)01108-X
doi: 10.1016/j.jtcvs.2023.11.032
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Nedadur R
      type: Person
      first name: Rashmi
      last name: Nedadur
      member of: Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Ontario, Canada.
  slot:
    index: 2
    item: Bhatt N
      type: Person
      first name: Nitish
      last name: Bhatt
      member of: Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Ontario, Canada.
  slot:
    index: 3
    item: Chung J
      type: Person
      first name: Jennifer
      last name: Chung
      member of: Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Ontario, Canada.
  slot:
    index: 4
    item: Chu MWA
      type: Person
      first name: Michael W A
      last name: Chu
      member of: Department of Cardiac Surgery, London Health Sciences Center, London, Ontario, Canada.
  slot:
    index: 5
    item: Ouzounian M
      type: Person
      first name: Maral
      last name: Ouzounian
      member of: Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Ontario, Canada. Electronic address: maral.ouzounian@uhn.ca.
  slot:
    index: 6
    item: Wang B
      type: Person
      first name: Bo
      last name: Wang
      member of: Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Ontario, Canada.
creator: Canadian Thoracic Aortic Collaborative
created: 2023-11-29T00:42
date last updated: 2025-01-17
issued: 2025-01
dp: 2025 Jan
created: 2023-11-28T19:13
e ISSN: 1097-685X
has issn l: 0022-5223
issue: 1
has NLM journal title abbreviation: J Thorac Cardiovasc Surg
publication name: The Journal of thoracic and cardiovascular surgery
language: eng
has national library of medicine journal id: 0376343
derived from: NLM
starting page: 59
ending page: 67.e4
has place of publication: United States
has primary subject term: D001013Q000601Q000000981
has primary subject term: http://id.nlm.nih.gov/mesh/D000069550
has primary subject term: http://id.nlm.nih.gov/mesh/D000066491
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000368
has subject term: D008875
has subject term: D018570
has subject term: D020521Q000209
has subject term: D012307
has subject term: D003661
has subject term: D016896
has subject term: D014656Q000009Q000401
has subject term: D012189
has subject term: D017558
source: J Thorac Cardiovasc Surg. 2025-01;169(1):59-67.e4.
volume: 169

LncRNA MALAT1-Targeting Antisense Oligonucleotide Ameliorates the AngII-Induced Vascular Smooth Muscle Cell Proliferation and Migration Through Nrf2/GPX4 Antioxidant Pathway.
pmid: 38086068
abstract: The high level of oxidative stress induced by angiotensin II (AngII) is the main pathophysiological process that promotes the proliferation and migration of vascular smooth muscle cells (VSMCs) and induces vascular remodeling. LncRNA metastasis-related lung adenocarcinoma transcript 1 (MALAT1) has been determined to play an important role in the modulation of oxidative stress and the development of cardiovascular diseases. Nevertheless, the function and underlying mechanism of MALAT1 in restenosis induced by hypertensive angioplasty remain unclear. AngII increased the expression of MALAT1 in VSMCs. We found that antisense oligonucleotide lncRNA MALAT1 (ASO-MALAT1) could inhibit AngII-induced reactive oxygen species production and VSMCs proliferation and migration by inducing the expression of glutathione peroxidase 4 (GPX4), which can be reversed by siRNA-GPX4. GPX4 overexpression can inhibit the proliferation and migration of VSMCs induced by AngII. In addition, we found that the process by which MALAT1 knockdown induces GPX4 expression involves nuclear factor erythrocyte 2-related factor 2 (Nrf2). Overexpression of Nrf2 can increase the expression of GPX4, and downregulation of GPX4 by ML385 (Nrf2 inhibitor) blocked the protective effect of ASO-MALAT1 on AngII-induced proliferation and migration of VSMCs. Ferrostatin-1 (Fer-1, ip 5 mg/kg per day for 2 weeks), a GPX4 agonist, significantly inhibited neointimal formation in spontaneously hypertensive rat by the inhibition of oxidative stress. In conclusion, these data imply that ASO-MALAT1 suppresses the AngII-induced oxidative stress, proliferation, and migration of VSMCs by activating Nrf2/GPX4 antioxidant signaling. GPX4 may be a potential target for the therapeutic intervention of hypertensive vascular restenosis.
rights: Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
has PII: 00005344-202411000-00007
doi: 10.1097/FJC.0000000000001521
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Liao Z
      type: Person
      first name: Zili
      last name: Liao
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 2
    item: Ni Z
      type: Person
      first name: Zhonghan
      last name: Ni
      member of: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 3
    item: Cao J
      type: Person
      first name: Jun
      last name: Cao
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
  slot:
    index: 4
    item: Liao J
      type: Person
      first name: Jin
      last name: Liao
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
  slot:
    index: 5
    item: Zhu H
      type: Person
      first name: Hengqing
      last name: Zhu
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
  slot:
    index: 6
    item: Zhong X
      type: Person
      first name: Xiutong
      last name: Zhong
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
  slot:
    index: 7
    item: Cao G
      type: Person
      first name: Gang
      last name: Cao
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
  slot:
    index: 8
    item: Huang L
      type: Person
      first name: Ling
      last name: Huang
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
  slot:
    index: 9
    item: Li X
      type: Person
      first name: Xiaoyue
      last name: Li
      member of: Department of Critical Care Medicine, Department of Emergency Medicine, the Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, China; and.
  slot:
    index: 10
    item: Jiang G
      type: Person
      first name: Guojun
      last name: Jiang
      member of: Department of Pharmacy, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
  slot:
    index: 11
    item: Pei F
      type: Person
      first name: Fang
      last name: Pei
      member of: Department of Cardiology, Ganzhou Hospital of Guangdong Provincial People's Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China.
created: 2023-12-12T18:42
date last updated: 2025-01-17
issued: 2024-11-01
dp: 2024 Nov 01
created: 2023-12-12T17:33
e ISSN: 1533-4023
has issn l: 0160-2446
issue: 5
has NLM journal title abbreviation: J Cardiovasc Pharmacol
publication name: Journal of cardiovascular pharmacology
language: eng
has national library of medicine journal id: 7902492
derived from: NLM
starting page: 515
ending page: 527
has place of publication: United States
has primary subject term: D062085Q000235Q000378
has primary subject term: D051267Q000378Q000235
has primary subject term: D009131Q000187Q000378Q000473
has primary subject term: D049109Q000187
has primary subject term: D000804Q000494
has primary subject term: D002465Q000187
has primary subject term: D032389Q000187Q000378Q000473
has primary subject term: D015398Q000187
has primary subject term: D018384Q000187
has primary subject term: D000080662Q000378Q000235
has subject term: D000818
has subject term: D008297
has subject term: D002478
has subject term: D017207
has subject term: D016376Q000494
has subject term: D004195
has subject term: D066253Q000187
has subject term: D000975Q000494
has subject term: D017382Q000378
has subject term: D051381
has subject term: D011918
source: J Cardiovasc Pharmacol. 2024-11-01;84(5):515-527.
volume: 84

Corrigendum to: C-reactive protein is associated with the development of tongue squamous cell carcinoma.
pmid: 38124538
doi: 10.3724/abbs.2023284
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Du J
      type: Person
      first name: Jianxin
      last name: Du
  slot:
    index: 2
    item: Hu W
      type: Person
      first name: Wei
      last name: Hu
  slot:
    index: 3
    item: Yang C
      type: Person
      first name: Chengzhe
      last name: Yang
  slot:
    index: 4
    item: Wang Y
      type: Person
      first name: Yegang
      last name: Wang
  slot:
    index: 5
    item: Wang X
      type: Person
      first name: Xiaoying
      last name: Wang
  slot:
    index: 6
    item: Yang P
      type: Person
      first name: Pishan
      last name: Yang
created: 2023-12-21T06:43
date last updated: 2025-01-17
issued: 2023-12-20
dp: 2023 Dec 20
created: 2023-12-21T03:16
e ISSN: 1745-7270
has issn l: 1672-9145
issue: 12
has NLM journal title abbreviation: Acta Biochim Biophys Sin (Shanghai)
publication name: Acta biochimica et biophysica Sinica
language: eng
has national library of medicine journal id: 101206716
derived from: NLM
pg: 1896
has place of publication: China
source: Acta Biochim Biophys Sin (Shanghai). 2023-12-20;56(12):1896.
volume: 56

Genetic variations of type 2 and type 3 von Willebrand diseases in Thailand.
pmid: 38053262
abstract: Von Willebrand disease (VWD) is an inherited haemostatic disorder with a wide range of bleeding phenotypes based on von Willebrand factor (VWF) levels. Multiple assays including VWF gene analysis are employed to correctly diagnose VWD and its subtypes. However, data on VWF mutations among Southeast Asian populations are lacking. We, therefore, aimed to explore genetic variations in Thai patients with type 2 and type 3 VWD by whole exome sequencing (WES).In this multicentre study, Thai patients with type 2 and type 3 VWD, according to the definitions and VWF levels recommended by the international guidelines, were recruited. WES was performed using DNA extracted from peripheral blood in all cases. The novel variants were verified by Sanger sequencing.Fifteen patients (73% females; median age at diagnosis 3.0 years) with type 2 (n=12) and type 3 VWD (n=3) from 14 families were enrolled. All patients harboured at least one VWF variant. Six missense (p.Arg1374Cys, p.Arg1374His, p.Arg1399Cys, p.Arg1597Trp, p.Ser1613Pro, p.Pro1648Arg) and one splice-site (c.3379+1G>A) variants in the VWF gene were formerly described. Notably, six VWF variants, including three missense (p.Met814Ile, p.Trp856Cys, p.Pro2032Leu), one deletion (c.2251delG) and two splice-site (c.7729+4A>C, c.8115+2delT) mutations were novelly identified. Compound heterozygosity contributed to type 2 and type 3 VWD phenotypes in two and one patients, respectively.Type 2 and type 3 VWD in Thailand demonstrate the mutational variations among VWF exons/introns with several unique variants. The WES-based approach potentially provides helpful information to verify VWD diagnosis and facilitate genetic counselling in clinical practice.
rights: © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.
has PII: jcp-2023-209123
doi: 10.1136/jcp-2023-209123
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Lauhasurayotin S
      type: Person
      first name: Supanun
      last name: Lauhasurayotin
      member of: Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Integrative and Innovative Hematology/Oncology Research Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  slot:
    index: 2
    item: Moonla C
      type: Person
      first name: Chatphatai
      last name: Moonla
      member of: Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Center of Excellence in Translational Hematology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  slot:
    index: 3
    item: Ittiwut R
      type: Person
      first name: Rungnapa
      last name: Ittiwut
      member of: Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
  slot:
    index: 4
    item: Ittiwut C
      type: Person
      first name: Chupong
      last name: Ittiwut
      member of: Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
  slot:
    index: 5
    item: Songthawee N
      type: Person
      first name: Natsaruth
      last name: Songthawee
      member of: Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
  slot:
    index: 6
    item: Komvilaisak P
      type: Person
      first name: Patcharee
      last name: Komvilaisak
      member of: Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
  slot:
    index: 7
    item: Natesirinilkul R
      type: Person
      first name: Rungrote
      last name: Natesirinilkul
      member of: Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
  slot:
    index: 8
    item: Sirachainan N
      type: Person
      first name: Nongnuch
      last name: Sirachainan
      member of: Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  slot:
    index: 9
    item: Rojnuckarin P
      type: Person
      first name: Ponlapat
      last name: Rojnuckarin
      member of: Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.Center of Excellence in Translational Hematology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  slot:
    index: 10
    item: Sosothikul D
      type: Person
      first name: Darintr
      last name: Sosothikul
      member of: Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand dsosothikul@hotmail.com.Integrative and Innovative Hematology/Oncology Research Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  slot:
    index: 11
    item: Suphapeetiporn K
      type: Person
      first name: Kanya
      last name: Suphapeetiporn
      member of: Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
created: 2023-12-6T06:42
date last updated: 2025-01-17
issued: 2024-12-18
dp: 2024 Dec 18
created: 2023-12-6T00:23
e ISSN: 1472-4146
has issn l: 0021-9746
issue: 1
has NLM journal title abbreviation: J Clin Pathol
publication name: Journal of clinical pathology
language: eng
has national library of medicine journal id: 0376601
derived from: NLM
starting page: 57
ending page: 63
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000073359
has primary subject term: D056728Q000235Q000175
has primary subject term: D056729Q000235Q000175
has primary subject term: D014841Q000235
has subject term: D000293
has subject term: D000328
has subject term: D002648
has subject term: D002675
has subject term: D005260
has subject term: D006801
has subject term: D007223
has subject term: D008297
has subject term: D004252
has subject term: D020022
has subject term: D014644
has subject term: D009154
has subject term: D010641
has subject term: D013785
source: J Clin Pathol. 2024-12-18;78(1):57-63.
volume: 78

Printed High-Adhesion Flexible Electrodes Based on an Interlocking Structure for Self-Powered Intelligent Movement Monitoring.
pmid: 38079512
abstract: Two-dimensional transition metal carbide nitrides (MXenes) have been extensively explored in diverse areas, such as electrochemical energy storage and flexible electronics. Although the solution-processed MXene-based device has made significant achievements, it is still a challenge to develop large-scale and high-resolution printing methods for flexible printed electronics. In this work, we reported a novel strategy of a porous interlocking structure to obtain flexible MXene/laser-induced graphene (LMX) composite electrodes with enhanced adhesion and high printing resolution. In comparison to traditional printed MXene electrodes, the LMX electrode with an interlocking interface possesses enhanced mechanical properties (adhesive strength of 2.17 MPa) and comparable electrical properties (0.68 S/mm). Furthermore, owing to the outstanding stability and flexibility, the LMX-based triboelectric nanogenerator (TENG) can be used as a self-powered sensor to monitor finger-bending movement. A support vector machine (SVM)-assisted self-powered motion sensor can distinguish the bending angle with high recognition accuracy and can effectively identify different angles. The successful experience of directly printing flexible electrodes with excellent mechanical and electrical properties can be promoted to other solution-processed two-dimensional materials. Our strategy opens up a promising perspective to develop flexible and printed electronics.
doi: 10.1021/acsami.3c13467
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Huang K
      type: Person
      first name: Kai
      last name: Huang
      member of: Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, People's Republic of China.Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology, Beijing 100083, People's Republic of China.
  slot:
    index: 2
    item: Cai X
      type: Person
      first name: Xu
      last name: Cai
      member of: Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People's Republic of China.
  slot:
    index: 3
    item: Shang R
      type: Person
      first name: Ruzhi
      last name: Shang
      member of: Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People's Republic of China.
  slot:
    index: 4
    item: Yang W
      type: Person
      first name: Wei
      last name: Yang
      member of: Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People's Republic of China.
  slot:
    index: 5
    item: Shi X
      type: Person
      first name: Xin
      last name: Shi
      member of: Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People's Republic of China.
  slot:
    index: 6
    item: Wang J
      type: Person
      first name: Jun
      last name: Wang
      member of: Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People's Republic of China.
  slot:
    index: 7
    item: Chen H
      type: Person
      first name: Huamin
      last name: Chen
      member of: Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, People's Republic of China.Fujian Key Laboratory of Functional Marine Sensing Materials, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, People's Republic of China.
  slot:
    index: 8
    item: Xu Y
      type: Person
      first name: Yun
      last name: Xu
      member of: Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, People's Republic of China.Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology, Beijing 100083, People's Republic of China.
created: 2023-12-11T18:43
date last updated: 2025-01-17
issued: 2023-12-20
dp: 2023 Dec 20
created: 2023-12-11T14:23
e ISSN: 1944-8252
has issn l: 1944-8244
issue: 50
has NLM journal title abbreviation: ACS Appl Mater Interfaces
publication name: ACS applied materials & interfaces
language: eng
has national library of medicine journal id: 101504991
derived from: NLM
starting page: 58583
ending page: 58592
has place of publication: United States
source: ACS Appl Mater Interfaces. 2023-12-20;15(50):58583-58592.
volume: 15

Perioperative oxygenation impairment related to type a aortic dissection.
pmid: 38174389
abstract: Type A aortic dissection (TAAD) is a life-threatening disease with high mortality and poor prognosis, usually treated by surgery. There are many complications in its perioperative period, one of which is oxygenation impairment (OI). As a common complication of TAAD, OI usually occurs throughout the perioperative period of TAAD and requires prolonged mechanical ventilation (MV) and other supportive measures. The purpose of this article is to review the risk factors, mechanisms, and treatments of type A aortic dissection-related oxygenation impairment (TAAD-OI) so as to improve clinicians' knowledge about it. Among risk factors, elevated body mass index (BMI), prolonged extracorporeal circulation (ECC) duration, higher inflammatory cells and stored blood transfusion stand out. A reduced occurrence of TAAD-OI can be achieved by controlling these risk factors such as suppressing inflammatory response by drugs. As for its mechanism, it is currently believed that inflammatory signaling pathways play a major role in this process, including the HMGB1/RAGE signaling pathway, gut-lung axis and macrophage, which have been gradually explored and are expected to provide evidences revealing the specific mechanism of TAAD-OI. Numerous treatments have been investigated for TAAD-OI, such as nitric oxide (NO), continuous pulmonary perfusion/inflation, ulinastatin and sivelestat sodium, immunomodulation intervention and mechanical support. However, these measures are all aimed at postoperative TAAD-OI, and not all of the therapies have shown satisfactory effects. Treatments for preoperative TAAD-OI are not currently available because it is difficult to correct OI without correcting the dissection. Therefore, the best solution for preoperative TAAD-OI is to operate as soon as possible. At present, there is no specific method for clinical application, and it relies more on the experience of clinicians or learns from treatments of other diseases related to oxygenation disorders. More eff[cell cut: 2098 characters, first 2000 kept]
doi: 10.1177/02676591231224997
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Liu Q
      type: Person
      first name: Qindong
      last name: Liu
      member of: Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  slot:
    index: 2
    item: Guan Y
      type: Person
      first name: Yulong
      last name: Guan
      member of: Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  slot:
    index: 3
    item: Yang X
      type: Person
      first name: Xiaofang
      last name: Yang
      member of: Department of Extracorporeal Circulation and Mechanical Circulation Assistants, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 4
    item: Jiang Y
      type: Person
      first name: Yu
      last name: Jiang
      member of: Department of Extracorporeal Circulation and Mechanical Circulation Assistants, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 5
    item: Hei F
      type: Person
      first name: Feilong
      last name: Hei
      member of: Department of Extracorporeal Circulation and Mechanical Circulation Assistants, Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
created: 2024-1-4T11:43
date last updated: 2025-01-17
issued: 2025-01
dp: 2025 Jan
created: 2024-1-4T04:27
e ISSN: 1477-111X
has issn l: 0267-6591
issue: 1
has NLM journal title abbreviation: Perfusion
publication name: Perfusion
language: eng
has national library of medicine journal id: 8700166
derived from: NLM
starting page: 49
ending page: 60
has place of publication: England
has primary subject term: D000784Q000601
has primary subject term: D010100Q000378
has primary subject term: D059035
has subject term: D006801
has subject term: D012307
source: Perfusion. 2025-01;40(1):49-60.
volume: 40

The use of protective mechanical ventilation during extracorporeal membrane oxygenation for the treatment of acute respiratory failure.
pmid: 38240747
abstract: Acute respiratory failure (ARF) strikes an estimated two million people in the United States each year, with care exceeding US$50 billion. The hallmark of ARF is a heterogeneous injury, with normal tissue intermingled with a large volume of low compliance and collapsed tissue. Mechanical ventilation is necessary to oxygenate and ventilate patients with ARF, but if set inappropriately, it can cause an unintended ventilator-induced lung injury (VILI). The mechanism of VILI is believed to be overdistension of the remaining normal tissue known as the 'baby' lung, causing volutrauma, repetitive collapse and reopening of lung tissue with each breath, causing atelectrauma, and inflammation secondary to this mechanical damage, causing biotrauma. To avoid VILI, extracorporeal membrane oxygenation (ECMO) can temporally replace the pulmonary function of gas exchange without requiring high tidal volumes (VT) or airway pressures. In theory, the lower VT and airway pressure will minimize all three VILI mechanisms, allowing the lung to 'rest' and heal in the collapsed state. The optimal method of mechanical ventilation for the patient on ECMO is unknown. The ARDSNetwork Acute Respiratory Management Approach (ARMA) is a Rest Lung Approach (RLA) that attempts to reduce the excessive stress and strain on the remaining normal lung tissue and buys time for the lung to heal in the collapsed state. Theoretically, excessive tissue stress and strain can also be avoided if the lung is fully open, as long as the alveolar re-collapse is prevented during expiration, an approach known as the Open Lung Approach (OLA). A third lung-protective strategy is the Stabilize Lung Approach (SLA), in which the lung is initially stabilized and gradually reopened over time. This review will analyze the physiologic efficacy and pathophysiologic potential of the above lung-protective approaches.
doi: 10.1177/02676591241227167
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Kingsley J
      type: Person
      first name: Julian
      last name: Kingsley
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 2
    item: Kandil O
      type: Person
      first name: Omneya
      last name: Kandil
      member of: Alexandria Faculty of Medicine, Alexandria, Egypt.
  slot:
    index: 3
    item: Satalin J
      type: Person
      first name: Joshua
      last name: Satalin
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 4
    item: Bary AA
      type: Person
      first name: Akram Abdel
      last name: Bary
      member of: Critical Care Department, Faculty of Medicine Cairo University, Cairo, Egypt.
  slot:
    index: 5
    item: Coyle S
      type: Person
      first name: Sierra
      last name: Coyle
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 6
    item: Nawar MS
      type: Person
      first name: Mahmoud Saad
      last name: Nawar
      member of: Critical Care Department, Faculty of Medicine Cairo University, Cairo, Egypt.
  slot:
    index: 7
    item: Groom R
      type: Person
      first name: Robert
      last name: Groom
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 8
    item: Farrag A
      type: Person
      first name: Amr
      last name: Farrag
      member of: Aswan Heart Centre, Magdi Yacoub Foundation, Aswan, Egypt.
  slot:
    index: 9
    item: Shah J
      type: Person
      first name: Jaffer
      last name: Shah
      member of: Weill Cornell Medicine, New York, NY, USA.
  slot:
    index: 10
    item: Robedee BR
      type: Person
      first name: Ben R
      last name: Robedee
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 11
    item: Darling E
      type: Person
      first name: Edward
      last name: Darling
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 12
    item: Shawkat A
      type: Person
      first name: Ahmed
      last name: Shawkat
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 13
    item: Chaudhuri D
      type: Person
      first name: Debanik
      last name: Chaudhuri
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 14
    item: Nieman GF
      type: Person
      first name: Gary F
      last name: Nieman
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
  slot:
    index: 15
    item: Aiash H
      type: Person
      first name: Hani
      last name: Aiash
      member of: SUNY Upstate Medical University, Syracuse, NY, USA.
created: 2024-1-19T12:43
date last updated: 2025-01-17
issued: 2025-01
dp: 2025 Jan
created: 2024-1-19T10:53
e ISSN: 1477-111X
has issn l: 0267-6591
issue: 1
has NLM journal title abbreviation: Perfusion
publication name: Perfusion
language: eng
has national library of medicine journal id: 8700166
derived from: NLM
starting page: 69
ending page: 82
has place of publication: England
has primary subject term: D015199Q000379
has primary subject term: D012121Q000379Q000009
has primary subject term: D012131Q000628
has subject term: D006801
has subject term: D012128Q000628Q000503
has subject term: D055397Q000517
source: Perfusion. 2025-01;40(1):69-82.
volume: 40

The Impact of Rapid Handpump Repairs on Diarrhea Morbidity in Children: Cross-Sectional Study in Kwale County, Kenya.
pmid: 38227359
abstract: Handpumps are used by millions of people as their main source of water. Although handpumps represent only a basic form of water provision, there have been continuous efforts to improve the performance of these systems as they are likely to remain in use for many years to come. The introduction of a professional maintenance service in southern Kenya has shown an order of magnitude improvement in operational performance over community-based management, with 90% of handpump faults repaired within 3 days of being reported. One driver behind these efforts is the assumption that a more reliable water supply will lead to a reduction in water-related disease. However, it is not clear if operational improvements lead to health gains. Despite limited empirical evidence, some modeling studies suggest that even short periods of drinking contaminated water can lead to disproportionate negative health impacts.The aim of this study was to assess whether the improvements in operational performance from the rapid professional maintenance of rural handpumps lead to improved household health outcomes.From a sample of households using handpumps as their primary water source in Kwale County, Kenya, we measured the 2-week prevalence of World Health Organization-defined diarrhea in children, reported by the adult respondent for each household. We compared the rates before and after a period during which the households' handpumps were being professionally maintained. We then conducted a cross-sectional analysis, fitting logistic regression models with reported diarrhea as the dependent variable and speed of repair as the independent exposure of interest, adjusting for household socioeconomic characteristics; dwelling construction; and Water, Sanitation, and Hygiene (WASH)-related factors. We fitted an additional model to examine select interactions between covariates.Reported diarrhea in children was lower in households whose pumps had been repaired within 24 hours (adjusted odds ratio 0.3[cell cut: 3022 characters, first 2000 kept]
rights: ©Patrick Thomson, Justin Stoler, Michelle Byford, David J Bradley. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 16.01.2024.
has PII: v10i1e42462
doi: 10.2196/42462
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Thomson P
      type: Person
      first name: Patrick
      last name: Thomson
      member of: School of Geography and the Environment, University of Oxford, Oxford, United Kingdom.Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
  slot:
    index: 2
    item: Stoler J
      type: Person
      first name: Justin
      last name: Stoler
      member of: Department of Geography and Sustainable Development, University of Miami, Coral Gables, FL, United States.Department of Public Health Sciences, University of Miami, Miami, FL, United States.
  slot:
    index: 3
    item: Byford M
      type: Person
      first name: Michelle
      last name: Byford
      member of: Barts Health NHS Trust, London, United Kingdom.
  slot:
    index: 4
    item: Bradley DJ
      type: Person
      first name: David J
      last name: Bradley
      member of: School of Geography and the Environment, University of Oxford, Oxford, United Kingdom.London School of Hygiene & Tropical Medicine, London, United Kingdom.
created: 2024-1-16T13:43
date last updated: 2025-01-17
issued: 2024-01-16
dp: 2024 01 16
created: 2024-1-16T11:53
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e42462
has place of publication: Canada
has primary subject term: D003967Q000453Q000517
has primary subject term: D014867
has subject term: D000328
has subject term: D002648
has subject term: D006801
has subject term: D003430
has subject term: D007630Q000453
has subject term: D009017
source: JMIR Public Health Surveill. 2024-01-16;10():e42462.
volume: 10

Dynamics of the Oral Microbiome During Initial Military Training at Fort Benning, Georgia.
pmid: 38243767
abstract: Military trainees are at increased risk for infectious disease outbreaks because of the unique circumstances of the training environment (e.g., close proximity areas and physiologic/psychologic stress). Standard medical countermeasures in military training settings include routine immunization (e.g., influenza and adenovirus) as well as chemoprophylaxis [e.g., benzathine penicillin G (Bicillin) for the prevention of group A streptococcal disease] for pathogens associated with outbreaks in these settings. In a population of U.S. Army Infantry trainees, we evaluated changes in the oral microbiome during a 14-week military training cycle.Trainees were enrolled in an observational cohort study in 2015-2016. In 2015, Bicillin was administered to trainees to ameliorate the risk of group A Streptococcus outbreaks, whereas in 2016, trainees did not receive a Bicillin inoculation. Oropharyngeal swabs were collected from participants at days 0, 7, 14, 28, 56, and 90 of training. Swabs were collected, flash frozen, and stored. DNA was extracted from swabs, and amplicon sequencing of the 16s rRNA gene was performed. Microbiome dynamics were evaluated using the QIIME 2 workflow along with DADA2, SINA with SILVA, and an additional processing in R.We observed that microbiome samples from the baseline (day 0) visit were distinct from one another, whereas samples collected on day 14 exhibited significant microbiome convergence. Day 14 convergence was coincident with an increase in DNA sequences associated with Streptococcus, though there was not a significant difference between Streptococcus abundance over time between 2015 and 2016 (P = .07), suggesting that Bicillin prophylaxis did not significantly impact overall Streptococcus abundance.The temporary convergence of microbiomes is coincident with a rise in communicable infections in this population. The dynamic response of microbiomes during initial military training supports similar observations in the literature of transient con[cell cut: 2230 characters, first 2000 kept]
rights: © The Association of Military Surgeons of the United States 2024. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577884
doi: 10.1093/milmed/usad488
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Zudock KK
      type: Person
      first name: Kristina K
      last name: Zudock
      member of: Research and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA.
  slot:
    index: 2
    item: Player R
      type: Person
      first name: Robert
      last name: Player
      member of: Asymmetric Operations Sector, Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA.
  slot:
    index: 3
    item: Ernlund A
      type: Person
      first name: Amanda
      last name: Ernlund
      member of: Research and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA.
  slot:
    index: 4
    item: Timm CM
      type: Person
      first name: Collin M
      last name: Timm
      member of: Asymmetric Operations Sector, Johns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA.
  slot:
    index: 5
    item: English CE
      type: Person
      first name: Caroline E
      last name: English
      member of: Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
  slot:
    index: 6
    item: Ellis MW
      type: Person
      first name: Michael W
      last name: Ellis
      member of: Division of Infectious Diseases, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
  slot:
    index: 7
    item: Tribble DR
      type: Person
      first name: David R
      last name: Tribble
      member of: Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  slot:
    index: 8
    item: Merrell DS
      type: Person
      first name: D Scott
      last name: Merrell
      member of: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  slot:
    index: 9
    item: Bennett JW
      type: Person
      first name: Jason W
      last name: Bennett
      member of: Multidrug-Resistant Organism Repository and Surveillance Network, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  slot:
    index: 10
    item: Millar EV
      type: Person
      first name: Eugene V
      last name: Millar
      member of: Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.
created: 2024-1-20T10:43
date last updated: 2025-01-17
issued: 2024-07-03
dp: 2024 Jul 03
created: 2024-1-20T05:29
e ISSN: 1930-613X
has issn l: 0026-4075
issue: 7-8
has NLM journal title abbreviation: Mil Med
publication name: Military medicine
language: eng
has national library of medicine journal id: 2984771R
derived from: NLM
starting page: e1753
ending page: e1759
has place of publication: England
has primary subject term: D064307Q000502
has primary subject term: D008889Q000706
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D015331
has subject term: D005845Q000453
has subject term: D009055Q000382
has subject term: D012336Q000032
source: Mil Med. 2024-07-03;189(7-8):e1753-e1759.
volume: 189

The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells.
pmid: 38309692
abstract: Transcription factors (TFs) fulfill a critical role in the formation and maintenance of different cell types during the developmental process as well as disease. It is believed that cancer-associated fibroblasts (CAFs) are activation status of tissue-resident fibroblasts or derived from form other cell types via transdifferentiation or dedifferentiation. Despite a subgroup of CAFs exhibit anti-cancer effects, most of them are reported to exert effects on tumor progression, further indicating their heterogeneous origin.This review aimed to summarize and review the roles of TFs in the reciprocal crosstalk between CAFs and tumor cells, discuss the emerging mechanisms, and their roles in cell-fate decision, cellular reprogramming and advancing our understanding of the gene regulatory networks over the period of cancer initiation and progression.This manuscript delves into the key contributory factors of TFs that are involved in activating CAFs and maintaining their unique states. Additionally, it explores how TFs play a pivotal and multifaceted role in the reciprocal crosstalk between CAFs and tumor cells. This includes their involvement in processes such as epithelial-mesenchymal transition (EMT), proliferation, invasion, and metastasis, as well as metabolic reprogramming. TFs also have a role in constructing an immunosuppressive microenvironment, inducing resistance to radiation and chemotherapy, facilitating angiogenesis, and even 'educating' CAFs to support the malignancies of tumor cells. Furthermore, this manuscript delves into the current status of TF-targeted therapy and considers the future directions of TFs in conjunction with anti-CAFs therapies to address the challenges in clinical cancer treatment.
rights: Copyright © 2024. Published by Elsevier B.V.
has PII: S2090-1232(24)00046-8
doi: 10.1016/j.jare.2024.01.033
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Zhang X
      type: Person
      first name: Xiaoyan
      last name: Zhang
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China.
  slot:
    index: 2
    item: Zhang M
      type: Person
      first name: Meng
      last name: Zhang
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China.
  slot:
    index: 3
    item: Sun H
      type: Person
      first name: Hui
      last name: Sun
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China.
  slot:
    index: 4
    item: Wang X
      type: Person
      first name: Xu
      last name: Wang
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China.
  slot:
    index: 5
    item: Wang X
      type: Person
      first name: Xin
      last name: Wang
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China.
  slot:
    index: 6
    item: Sheng W
      type: Person
      first name: Weiqi
      last name: Sheng
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China. Electronic address: shengweiqi2006@163.com.
  slot:
    index: 7
    item: Xu M
      type: Person
      first name: Midie
      last name: Xu
      member of: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Institute of Pathology, Fudan University, Shanghai 200032, China. Electronic address: xumd27202003@sina.com.
created: 2024-2-4T00:42
date last updated: 2025-01-17
issued: 2025-01
dp: 2025 Jan
created: 2024-2-3T19:36
e ISSN: 2090-1224
has issn l: 2090-1224
has NLM journal title abbreviation: J Adv Res
publication name: Journal of advanced research
language: eng
has national library of medicine journal id: 101546952
derived from: NLM
starting page: 121
ending page: 132
has place of publication: Egypt
has primary subject term: D000072645Q000378
has primary subject term: D014157Q000378
has primary subject term: D009369Q000378Q000473
has primary subject term: D058750
has primary subject term: D059016
has subject term: D006801
has subject term: D015972
has subject term: D065150
has subject term: D000818
has subject term: D053263
has subject term: D049109
source: J Adv Res. 2025-01;67():121-132.
volume: 67

Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates.
pmid: 38349372
abstract: The US heart allocation system prioritizes medically urgent candidates with a high risk of dying without transplant. The current therapy-based 6-status system is susceptible to manipulation and has limited rank ordering ability.To develop and validate a candidate risk score that incorporates current clinical, laboratory, and hemodynamic data.A registry-based observational study of adult heart transplant candidates (aged ≥18 years) from the US heart allocation system listed between January 1, 2019, and December 31, 2022, split by center into training (70%) and test (30%) datasets. Adult candidates were listed between January 1, 2019, and December 31, 2022.A US candidate risk score (US-CRS) model was developed by adding a predefined set of predictors to the current French Candidate Risk Score (French-CRS) model. Sensitivity analyses were performed, which included intra-aortic balloon pumps (IABP) and percutaneous ventricular assist devices (VAD) in the definition of short-term mechanical circulatory support (MCS) for the US-CRS. Performance of the US-CRS model, French-CRS model, and 6-status model in the test dataset was evaluated by time-dependent area under the receiver operating characteristic curve (AUC) for death without transplant within 6 weeks and overall survival concordance (c-index) with integrated AUC.A total of 16 905 adult heart transplant candidates were listed (mean [SD] age, 53 [13] years; 73% male; 58% White); 796 patients (4.7%) died without a transplant. The final US-CRS contained time-varying short-term MCS (ventricular assist-extracorporeal membrane oxygenation or temporary surgical VAD), the log of bilirubin, estimated glomerular filtration rate, the log of B-type natriuretic peptide, albumin, sodium, and durable left ventricular assist device. In the test dataset, the AUC for death within 6 weeks of listing for the US-CRS model was 0.79 (95% CI, 0.75-0.83), for the French-CRS model was 0.72 (95% CI, 0.67-0.76), and 6-status model was 0.68 (95% [cell cut: 2551 characters, first 2000 kept]
has PII: 2814884
doi: 10.1001/jama.2023.27029
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Zhang KC
      type: Person
      first name: Kevin C
      last name: Zhang
      member of: Department of Medicine, University of Chicago, Chicago, Illinois.
  slot:
    index: 2
    item: Narang N
      type: Person
      first name: Nikhil
      last name: Narang
      member of: Advocate Heart Institute, Advocate Christ Medical Center, Oak Lawn, Illinois.Department of Medicine, University of Illinois-Chicago.
  slot:
    index: 3
    item: Jasseron C
      type: Person
      first name: Carine
      last name: Jasseron
      member of: Agence de la Biomédecine, Direction Prélèvement Greffe Organes-Tissus, Saint-Denis La Plaine, France.
  slot:
    index: 4
    item: Dorent R
      type: Person
      first name: Richard
      last name: Dorent
      member of: Agence de la Biomédecine, Direction Prélèvement Greffe Organes-Tissus, Saint-Denis La Plaine, France.
  slot:
    index: 5
    item: Lazenby KA
      type: Person
      first name: Kevin A
      last name: Lazenby
      member of: Pritzker School of Medicine, University of Chicago, Chicago, Illinois.
  slot:
    index: 6
    item: Belkin MN
      type: Person
      first name: Mark N
      last name: Belkin
      member of: Department of Medicine, University of Chicago, Chicago, Illinois.
  slot:
    index: 7
    item: Grinstein J
      type: Person
      first name: Jonathan
      last name: Grinstein
      member of: Department of Medicine, University of Chicago, Chicago, Illinois.
  slot:
    index: 8
    item: Mayampurath A
      type: Person
      first name: Anoop
      last name: Mayampurath
      member of: Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison.
  slot:
    index: 9
    item: Churpek MM
      type: Person
      first name: Matthew M
      last name: Churpek
      member of: Department of Medicine, University of Wisconsin, Madison.
  slot:
    index: 10
    item: Khush KK
      type: Person
      first name: Kiran K
      last name: Khush
      member of: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
  slot:
    index: 11
    item: Parker WF
      type: Person
      first name: William F
      last name: Parker
      member of: Department of Medicine, University of Chicago, Chicago, Illinois.Department of Public Health Sciences, University of Chicago, Chicago, Illinois.MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, Illinois.
created: 2024-2-13T12:47
date last updated: 2025-01-17
issued: 2024-02-13
dp: 2024 02 13
created: 2024-2-13T11:05
e ISSN: 1538-3598
has issn l: 0098-7484
issue: 6
has NLM journal title abbreviation: JAMA
publication name: JAMA
language: eng
has national library of medicine journal id: 7501160
derived from: NLM
starting page: 500
ending page: 509
has place of publication: United States
has primary subject term: D016027
has primary subject term: D006333Q000401Q000601
has primary subject term: D009927Q000379Q000458
has subject term: D000328
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D001663
has subject term: D064790
has subject term: D006321
has subject term: D012307
has subject term: D018570
has subject term: D014481
has subject term: D015276Q000379
has subject term: D011237
source: JAMA. 2024-02-13;331(6):500-509.
volume: 331

Association Between Nitrogen Dioxide Pollution and Cause-Specific Mortality in China: Cross-Sectional Time Series Study.
pmid: 38315528
abstract: Nitrogen dioxide (NO2) has been frequently linked to a range of diseases and associated with high rates of mortality and morbidity worldwide. However, there is limited evidence regarding the risk of NO2 on a spectrum of causes of mortality. Moreover, adjustment for potential confounders in NO2 analysis has been insufficient, and the spatial resolution of exposure assessment has been limited.This study aimed to quantitatively assess the relationship between short-term NO2 exposure and death from a range of causes by adjusting for potential confounders in Guangzhou, China, and determine the modifying effect of gender and age.A time series study was conducted on 413,703 deaths that occurred in Guangzhou during the period of 2010 to 2018. The causes of death were classified into 10 categories and 26 subcategories. We utilized a generalized additive model with quasi-Poisson regression analysis using a natural cubic splines function with lag structure of 0 to 4 days to estimate the potential lag effect of NO2 on cause-specific mortality. We estimated the percentage change in cause-specific mortality rates per 10 μg/m3 increase in NO2 levels. We stratified meteorological factors such as temperature, humidity, wind speed, and air pressure into high and low levels with the median as the critical value and analyzed the effects of NO2 on various death-causing diseases at those high and low levels. To further identify potentially vulnerable subpopulations, we analyzed groups stratified by gender and age.A significant association existed between NO2 exposure and deaths from multiple causes. Each 10 μg/m3 increment in NO2 density at a lag of 0 to 4 days increased the risks of all-cause mortality by 1.73% (95% CI 1.36%-2.09%) and mortality due to nonaccidental causes, cardiovascular disease, respiratory disease, endocrine disease, and neoplasms by 1.75% (95% CI 1.38%-2.12%), 2.06% (95% CI 1.54%-2.59%), 2.32% (95% CI 1.51%-3.13%), 2.40% (95% CI 0.84%-3.98%), and 1.18% (95% CI 0.59%[cell cut: 2953 characters, first 2000 kept]
rights: ©Jie Zeng, Guozhen Lin, Hang Dong, Mengmeng Li, Honglian Ruan, Jun Yang. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 05.02.2024.
has PII: v10i1e44648
doi: 10.2196/44648
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zeng J
      type: Person
      first name: Jie
      last name: Zeng
      member of: Department of Internet Medical Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
  slot:
    index: 2
    item: Lin G
      type: Person
      first name: Guozhen
      last name: Lin
      member of: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.Institute of Public Health, Guangzhou Medical University and Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  slot:
    index: 3
    item: Dong H
      type: Person
      first name: Hang
      last name: Dong
      member of: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.Institute of Public Health, Guangzhou Medical University and Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  slot:
    index: 4
    item: Li M
      type: Person
      first name: Mengmeng
      last name: Li
      member of: State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
  slot:
    index: 5
    item: Ruan H
      type: Person
      first name: Honglian
      last name: Ruan
      member of: School of Public Health, Guangzhou Medical University, Guangzhou, China.
  slot:
    index: 6
    item: Yang J
      type: Person
      first name: Jun
      last name: Yang
      member of: School of Public Health, Guangzhou Medical University, Guangzhou, China.
created: 2024-2-5T14:43
date last updated: 2025-01-17
issued: 2024-02-05
dp: 2024 02 05
created: 2024-2-5T11:53
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e44648
has place of publication: Canada
has primary subject term: D000393Q000009Q000032
has primary subject term: D000397Q000009Q000032
has primary subject term: D002318
has primary subject term: D004700
has subject term: D006801
has subject term: D009585Q000009Q000032
has subject term: D002423
has subject term: D013997
has subject term: D003430
has subject term: D002681Q000453
source: JMIR Public Health Surveill. 2024-02-05;10():e44648.
volume: 10

Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut.
pmid: 38315494
abstract: Glaucoma is an eye disease that is the most common cause of irreversible blindness worldwide. It has been suggested that gut microbiota can produce reactive oxygen species and pro-inflammatory cytokines that may travel from the gastric mucosa to distal sites, for example, the optic nerve head or trabecular meshwork. There is evidence for a gut-eye axis, as microbial dysbiosis has been associated with retinal diseases. We investigated the microbial composition in patients with glaucoma and healthy controls. Moreover, we analyzed the association of the gut microbiome with intraocular pressure (IOP; risk factor of glaucoma) and vertical cup-to-disc ratio (VCDR; quantifying glaucoma severity).The discovery analyses included participants of the Rotterdam Study and the Erasmus Glaucoma Cohort. A total of 225 patients with glaucoma and 1247 age- and sex-matched participants without glaucoma were included in our analyses. Stool samples were used to generate 16S rRNA gene profiles. We assessed associations with 233 genera and species. We used data from the TwinsUK and the Study of Health in Pomerania (SHIP) to replicate our findings.Several butyrate-producing taxa (e.g. Butyrivibrio, Caproiciproducens, Clostridium sensu stricto 1, Coprococcus 1, Ruminococcaceae UCG 007, and Shuttleworthia) were less abundant in people with glaucoma compared to healthy controls. The same taxa were also associated with lower IOP and smaller VCDR. The replication analyses confirmed the findings from the discovery analyses.Large human studies exploring the link between the gut microbiome and glaucoma are lacking. Our results suggest that microbial dysbiosis plays a role in the pathophysiology of glaucoma.
has PII: 2793347
doi: 10.1167/iovs.65.2.7
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Vergroesen JE
      type: Person
      first name: Joëlle E
      last name: Vergroesen
      member of: Department of Ophthalmology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  slot:
    index: 2
    item: Jarrar ZA
      type: Person
      first name: Zakariya A
      last name: Jarrar
      member of: Department of Ophthalmology, King's College London, London, United Kingdom.Department of Twins Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  slot:
    index: 3
    item: Weiss S
      type: Person
      first name: Stefan
      last name: Weiss
      member of: Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
  slot:
    index: 4
    item: Frost F
      type: Person
      first name: Fabian
      last name: Frost
      member of: Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
  slot:
    index: 5
    item: Ansari AS
      type: Person
      first name: Abdus S
      last name: Ansari
      member of: Department of Ophthalmology, King's College London, London, United Kingdom.Department of Twins Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  slot:
    index: 6
    item: Nguyen P
      type: Person
      first name: Picard
      last name: Nguyen
      member of: Department of Ophthalmology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  slot:
    index: 7
    item: Kraaij R
      type: Person
      first name: Robert
      last name: Kraaij
      member of: Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  slot:
    index: 8
    item: Medina-Gomez C
      type: Person
      first name: Carolina
      last name: Medina-Gomez
      member of: Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  slot:
    index: 9
    item: Völzke H
      type: Person
      first name: Henry
      last name: Völzke
      member of: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  slot:
    index: 10
    item: Tost F
      type: Person
      first name: Frank
      last name: Tost
      member of: Department of Ophthalmology, University Medicine Greifswald, Greifswald, Germany.
  slot:
    index: 11
    item: Amin N
      type: Person
      first name: Najaf
      last name: Amin
      member of: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
  slot:
    index: 12
    item: van Duijn CM
      type: Person
      first name: Cornelia M
      last name: van Duijn
      member of: Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
  slot:
    index: 13
    item: Klaver CCW
      type: Person
      first name: Caroline C W
      last name: Klaver
      member of: Department of Ophthalmology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.Institute of Molecular and Clinical Ophthalmology, University of Basel, Basel, Switzerland.
  slot:
    index: 14
    item: Jürgens C
      type: Person
      first name: Clemens
      last name: Jürgens
      member of: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  slot:
    index: 15
    item: Hammond CJ
      type: Person
      first name: Chris J
      last name: Hammond
      member of: Department of Ophthalmology, King's College London, London, United Kingdom.Department of Twins Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  slot:
    index: 16
    item: Ramdas WD
      type: Person
      first name: Wishal D
      last name: Ramdas
      member of: Department of Ophthalmology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
created: 2024-2-5T14:45
date last updated: 2025-01-17
issued: 2024-02-01
dp: 2024 Feb 01
created: 2024-2-5T11:35
e ISSN: 1552-5783
has issn l: 0146-0404
issue: 2
has NLM journal title abbreviation: Invest Ophthalmol Vis Sci
publication name: Investigative ophthalmology & visual science
language: eng
has national library of medicine journal id: 7703701
derived from: NLM
pg: 7
has place of publication: United States
has primary subject term: D005901
has primary subject term: D009898
has subject term: D006801
has subject term: D002087
has subject term: D064806
has subject term: D012336Q000235
source: Invest Ophthalmol Vis Sci. 2024-02-01;65(2):7.
volume: 65

Cytogenotoxicity effects in addicts with multidrug consumption.
pmid: 38353119
abstract: Drug abuse is considered a global health problem with serious social impact. In recent decades, changes in drug consumption patterns have shown a clear rising trend in the use of multiple drugs. Although the buccal micronucleus cytome (BMCyt) assay has evaluated cytotoxicity in drug abuse, there has not been an approach that takes into account this pattern of multiple drug use. Therefore, in this study, we evaluate for the first time the cytogenotoxic effects in multidrug users, and its correlation with the amount consumed and years of abuse. This study was conducted on 166 individuals by the BMCyt assay. A total of 83 individuals with a history of multiple licit (alcohol and tobacco) and at least one illicit drug abuse (marijuana, methamphetamines, cocaine, and/or inhalants), and 83 healthy individuals, non-drug abusers were analyzed. The results showed that drug abusers had higher frequencies of nuclear abnormalities nuclear buds, binucleated cells, pyknotic nuclei (PNs), karyorrhexis (KX), and abnormally condensed chromatin when compared with healthy controls. Moreover, results suggests that the use of licit and illicit drugs is related to cytogenotoxic damage, as was shown by an upward trend in the frequency of nuclear abnormalities identified in groups 1 (alcohol + tobacco + at least one illicit drug) and 2 (tobacco + at least one illicit drug). Furthermore, a positive correlation was found in the different groups, between the years and the amount of consumption of some drugs (alcohol, methamphetamine, and tobacco) with cytotoxicity markers such as KL, KX, and PNs.
rights: © 2024 Environmental Mutagenesis and Genomics Society.
doi: 10.1002/em.22584
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: González-Santiago AE
      type: Person
      first name: Ana Elizabeth
      last name: González-Santiago
      member of: Departamento de Ciencias Biomédicas, División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, Mexico.
  slot:
    index: 2
    item: Gómez-Cabrera AS
      type: Person
      first name: Alejandro Salvador
      last name: Gómez-Cabrera
      member of: Departamento de Ciencias Biomédicas, División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, Mexico.
  slot:
    index: 3
    item: Baptista-Rosas RC
      type: Person
      first name: Raúl Cuauhtémoc
      last name: Baptista-Rosas
      member of: Departamento de Ciencias de la Salud-Enfermedad como Proceso Individual, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, Mexico.Unidad de intervención de Medicina Crítica, Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, Jalisco, Mexico.
  slot:
    index: 4
    item: Zúñiga-González GM
      type: Person
      first name: Guillermo Moisés
      last name: Zúñiga-González
      member of: Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico.
  slot:
    index: 5
    item: Gómez-Meda BC
      type: Person
      first name: Belinda Claudia
      last name: Gómez-Meda
      member of: Instituto de Genética Humana Dr. Enrique Corona Rivera, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  slot:
    index: 6
    item: Navarro AAS
      type: Person
      first name: Ana Alondra Sobrevilla
      last name: Navarro
      member of: Departamento de Ciencias Biomédicas, División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, Mexico.
  slot:
    index: 7
    item: Sánchez-Parada MG
      type: Person
      first name: María Guadalupe
      last name: Sánchez-Parada
      member of: Departamento de Ciencias Biomédicas, División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, Jalisco, Mexico.
created: 2024-2-14T06:43
date last updated: 2025-01-17
created: 2024-2-14T05:28
e ISSN: 1098-2280
has issn l: 0893-6692
issue: 1-2
has NLM journal title abbreviation: Environ Mol Mutagen
publication name: Environmental and molecular mutagenesis
language: eng
has national library of medicine journal id: 8800109
derived from: NLM
starting page: 84
ending page: 95
has place of publication: United States
has primary subject term: D019966
has primary subject term: D013287Q000633
has subject term: D006801
has subject term: D015162Q000379
has subject term: D002467
has subject term: D016923
has subject term: D009061
source: Environ Mol Mutagen. ;65(1-2):84-95.
volume: 65

The Use of ICD-9-CM Coding to Identify COVID-19 Diagnoses and Determine Risk Factors for 30-Day Death Rate in Hospitalized Patients in Italy: Retrospective Study.
pmid: 38393763
abstract: In Italy, it has been difficult to accurately quantify hospital admissions of patients with a COVID-19 diagnosis using the Hospital Information System (HIS), mainly due to the heterogeneity of codes used in the hospital discharge records during different waves of the COVID-19 pandemic.The objective of this study was to define a specific combination of codes to identify the COVID-19 hospitalizations within the HIS and to investigate the risk factors associated with mortality due to COVID-19 among patients admitted to Italian hospitals in 2020.A retrospective study was conducted using the hospital discharge records, provided by more than 1300 public and private Italian hospitals. Inpatient hospitalizations were detected by implementing an algorithm based on specific International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code combinations. Hospitalizations were analyzed by different clinical presentations associated with COVID-19 diagnoses. In addition, 2 multivariable Cox regression models were performed among patients hospitalized due to COVID-19 from January 1 to December 31, 2020, to investigate potential risk factors associated with 30-day death and the temporal changes over the course of the pandemic; in particular, the 30-day death rates during the first and the second waves were analyzed across 3 main geographical areas (North, Center, and South and Islands) and by discharge wards (ordinary and intensive care).We identified a total of 325,810 hospitalizations with COVID-19-related diagnosis codes. Among these, 73.4% (n=239,114) were classified as due to COVID-19, 14.5% (n=47,416) as SARS-CoV-2 positive, but not due to COVID-19, and 12.1% (n=39,280) as suspected COVID-19 hospitalizations. The cohort of patients hospitalized due to COVID-19 included 205,048 patients, with a median age of 72 years and a higher prevalence of male patients (n=124,181, 60.6%). The overall 30-day death rate among hospitalized patients due to COVID-1[cell cut: 2910 characters, first 2000 kept]
rights: ©Barbara Giordani, Alessandra Burgio, Francesco Grippo, Alessandra Barone, Erica Eugeni, Giovanni Baglio. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 23.02.2024.
has PII: v10i1e44062
doi: 10.2196/44062
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Giordani B
      type: Person
      first name: Barbara
      last name: Giordani
      member of: Research, National Outcomes Evaluation Programme (PNE) and International Relations Unit, Italian National Agency for Regional Healthcare Services, Rome, Italy.
  slot:
    index: 2
    item: Burgio A
      type: Person
      first name: Alessandra
      last name: Burgio
      member of: Italian National Institute of Statistics, Rome, Italy.
  slot:
    index: 3
    item: Grippo F
      type: Person
      first name: Francesco
      last name: Grippo
      member of: Italian National Institute of Statistics, Rome, Italy.
  slot:
    index: 4
    item: Barone A
      type: Person
      first name: Alessandra
      last name: Barone
      member of: Research, National Outcomes Evaluation Programme (PNE) and International Relations Unit, Italian National Agency for Regional Healthcare Services, Rome, Italy.
  slot:
    index: 5
    item: Eugeni E
      type: Person
      first name: Erica
      last name: Eugeni
      member of: Research, National Outcomes Evaluation Programme (PNE) and International Relations Unit, Italian National Agency for Regional Healthcare Services, Rome, Italy.
  slot:
    index: 6
    item: Baglio G
      type: Person
      first name: Giovanni
      last name: Baglio
      member of: Research, National Outcomes Evaluation Programme (PNE) and International Relations Unit, Italian National Agency for Regional Healthcare Services, Rome, Italy.
created: 2024-2-23T12:43
date last updated: 2025-01-17
issued: 2024-02-23
dp: 2024 02 23
created: 2024-2-23T11:53
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e44062
has place of publication: Canada
has primary subject term: D000086382Q000175Q000453
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000368
has subject term: D012189
has subject term: D038801
has subject term: http://id.nlm.nih.gov/mesh/D000086742
has subject term: D058873
has subject term: http://id.nlm.nih.gov/mesh/D000086402
has subject term: D012307
source: JMIR Public Health Surveill. 2024-02-23;10():e44062.
volume: 10

The Framing Effect of Digital Textual Messages on Uptake Rates of Medical Checkups: Field Study.
pmid: 38446543
abstract: Health care authorities often use text messages to enhance compliance with medical recommendations. The effectiveness of different message framings has been studied extensively over the past 3 decades. Recently, health care providers have begun using digital media platforms to disseminate health-related messages.This study aimed to examine the effectiveness of some of the most widely used message framings on the uptake rates of medical checkups.This study used a large-scale digital outreach campaign conducted by Maccabi Healthcare Services (MHS) during 2020-2021, involving a total of 113,048 participants. MHS members aged 50-74 years were invited to take their recommended medical actions from the following list: human papillomavirus (HPV), mammography, abdominal aortic aneurysm, fecal occult blood test (FOBT), and pneumococcal vaccination. Each member was randomly assigned to receive 1 of 6 message framings: control (neutrally framed; n=20,959, 18.5%), gains (benefits of compliance; n=20,393, 18%), losses (negative consequences of noncompliance; n=15,165, 13.4%), recommendation (a recommendation by an authoritative figure, in this context by a physician; n=20,584, 18.2%), implementation intentions (linking potential outcomes to future reactions; n=20,701, 18.3%), and empowerment (emphasizing personal responsibility for maintaining good health; n=15,246, 13.5%). The time frames for measuring a successful intervention were 14 days for scheduling screenings (ie, HPV, mammography, or abdominal aortic aneurysm), 30 days for performing the FOBT, and 60 days for receiving pneumococcal vaccination. We also examined the effectiveness of media channels (text message or email) on uptake rates and whether the subject-line length is correlated with message-opening rates.No significant effect of message framing on uptake rates of medical checkups was observed. The rates of appointments for screening ranged from 12.9% to 14.1% across treatments. Based on a chi-square test, there w[cell cut: 2899 characters, first 2000 kept]
rights: ©Amnon Maltz, Stella Rashkovich, Adi Sarid, Yafit Cohen, Tamar Landau, Elina Saifer, Neta Amorai Belkin, Tamar Alcalay. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 06.03.2024.
has PII: v10i1e45379
doi: 10.2196/45379
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Maltz A
      type: Person
      first name: Amnon
      last name: Maltz
      member of: Department of Economics, University of Haifa, Haifa, Israel.
  slot:
    index: 2
    item: Rashkovich S
      type: Person
      first name: Stella
      last name: Rashkovich
      member of: Nursing Division, Maccabi Healthcare Services, Tel Aviv, Israel.
  slot:
    index: 3
    item: Sarid A
      type: Person
      first name: Adi
      last name: Sarid
      member of: Sarid Research Services, Haifa, Israel.
  slot:
    index: 4
    item: Cohen Y
      type: Person
      first name: Yafit
      last name: Cohen
      member of: Marketing Automation Department, Maccbi Healthcare Services, Tel Aviv, Israel.
  slot:
    index: 5
    item: Landau T
      type: Person
      first name: Tamar
      last name: Landau
      member of: AI & Big Data Department, Maccabi Healthcare Services, Tel Aviv, Israel.
  slot:
    index: 6
    item: Saifer E
      type: Person
      first name: Elina
      last name: Saifer
      member of: Marketing Automation Department, Maccbi Healthcare Services, Tel Aviv, Israel.
  slot:
    index: 7
    item: Amorai Belkin N
      type: Person
      first name: Neta
      last name: Amorai Belkin
      member of: Marketing Automation Department, Maccbi Healthcare Services, Tel Aviv, Israel.
  slot:
    index: 8
    item: Alcalay T
      type: Person
      first name: Tamar
      last name: Alcalay
      member of: Nursing Division, Maccabi Healthcare Services, Tel Aviv, Israel.
created: 2024-3-6T12:42
date last updated: 2025-01-17
issued: 2024-03-06
dp: 2024 03 06
created: 2024-3-6T11:54
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e45379
has place of publication: Canada
has primary subject term: D017544
has primary subject term: D030361
has primary subject term: D060145
has subject term: D006801
has subject term: D006268
has subject term: D020407
has subject term: D008875
has subject term: D000368
source: JMIR Public Health Surveill. 2024-03-06;10():e45379.
volume: 10

Therapeutic strategies and outcomes in neuropsychiatric systemic lupus erythematosus: an international multicentre retrospective study.
pmid: 38402539
abstract: The management of neuropsychiatric systemic lupus erythematosus (NPSLE) poses considerable challenges due to limited clinical trials. Therapeutic decisions are customized based on suspected pathogenic mechanisms and symptoms severity. This study aimed to investigate therapeutic strategies and disease outcome for patients with NPSLE experiencing their first neuropsychiatric (NP) manifestation.This retrospective cohort study defined NP events according to the American College of Rheumatology case definition, categorizing them into three clusters: central/diffuse, central/focal and peripheral. Clinical judgment and a validated attribution algorithm were used for NP event attribution. Data included demographic variables, SLE disease activity index, cumulative organ damage, and NP manifestation treatments. The clinical outcome of all NP events was determined by a physician seven-point Likert scale. Predictors of clinical improvement/resolution were investigated in a multivariable logistic regression analysis.The analysis included 350 events. Immunosuppressants and corticosteroids were more frequently initiated/escalated for SLE-attributed central diffuse or focal NP manifestations. At 12 months of follow-up, 64% of patients showed a clinical improvement in NP manifestations. Focal central events and SLE-attributed manifestations correlated with higher rates of clinical improvement. Patients with NP manifestations attributed to SLE according to clinical judgment and treated with immunosuppressants had a significantly higher probability of achieving clinical response (OR 2.55, 95%CI 1.06-6.41, P = 0.04). Age at diagnosis and focal central events emerged as additional response predictors.NP manifestations attributed to SLE by clinical judgment and treated with immunosuppressants demonstrated improved 12-month outcomes. This underscores the importance of accurate attribution and timely diagnosis of NPSLE.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
has PII: 7613962
doi: 10.1093/rheumatology/keae119
creator: OrderedList
  length: 26
  slot:
    index: 1
    item: Bortoluzzi A
      type: Person
      first name: Alessandra
      last name: Bortoluzzi
      member of: Section of Rheumatology, Department of Medical Sciences University of Ferrara and Azienda Ospedaliera-Universitaria di Ferrara, Cona, Italy.
  slot:
    index: 2
    item: Fanouriakis A
      type: Person
      first name: Antonis
      last name: Fanouriakis
      member of: Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  slot:
    index: 3
    item: Silvagni E
      type: Person
      first name: Ettore
      last name: Silvagni
      member of: Section of Rheumatology, Department of Medical Sciences University of Ferrara and Azienda Ospedaliera-Universitaria di Ferrara, Cona, Italy.
  slot:
    index: 4
    item: Appenzeller S
      type: Person
      first name: Simone
      last name: Appenzeller
      member of: Rheumatology Unit, Department of Orthopedics, Rheumatology and Traumatology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
  slot:
    index: 5
    item: Carli L
      type: Person
      first name: Linda
      last name: Carli
      member of: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  slot:
    index: 6
    item: Carrara G
      type: Person
      first name: Greta
      last name: Carrara
      member of: Epidemiology Unit, Italian Society of Rheumatology, Milan, Italy.
  slot:
    index: 7
    item: Cauli A
      type: Person
      first name: Alberto
      last name: Cauli
      member of: Rheumatology Unit, University Clinic, AOU Cagliari, Cagliari, Italy.Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
  slot:
    index: 8
    item: Conti F
      type: Person
      first name: Fabrizio
      last name: Conti
      member of: Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari (SCIAC), Sapienza University, Rome, Italy.
  slot:
    index: 9
    item: Costallat LTL
      type: Person
      first name: Lilian Teresa Lavras
      last name: Costallat
      member of: Rheumatology Unit, Department of Orthopedics, Rheumatology and Traumatology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
  slot:
    index: 10
    item: De Marchi G
      type: Person
      first name: Ginevra
      last name: De Marchi
      member of: Rheumatology Unit, University of Udine, Department of Medicine, University Hospital Santa Maria della Misericordia, Udine, Italy.
  slot:
    index: 11
    item: Doria A
      type: Person
      first name: Andrea
      last name: Doria
      member of: Rheumatology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy.
  slot:
    index: 12
    item: Fredi M
      type: Person
      first name: Micaela
      last name: Fredi
      member of: Rheumatology and Clinical Immunology Unit and Clinical and Experimental Science Department ASST Spedali Civili and University of Brescia, Brescia, Italy.
  slot:
    index: 13
    item: Franceschini F
      type: Person
      first name: Franco
      last name: Franceschini
      member of: Rheumatology and Clinical Immunology Unit and Clinical and Experimental Science Department ASST Spedali Civili and University of Brescia, Brescia, Italy.
  slot:
    index: 14
    item: Garaffoni C
      type: Person
      first name: Carlo
      last name: Garaffoni
      member of: Section of Rheumatology, Department of Medical Sciences University of Ferrara and Azienda Ospedaliera-Universitaria di Ferrara, Cona, Italy.
  slot:
    index: 15
    item: Hanly JG
      type: Person
      first name: John G
      last name: Hanly
      member of: Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada.
  slot:
    index: 16
    item: Mosca M
      type: Person
      first name: Marta
      last name: Mosca
      member of: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  slot:
    index: 17
    item: Murphy E
      type: Person
      first name: Elana
      last name: Murphy
      member of: Division of Rheumatology, Departments of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Center, Halifax, NS, Canada.
  slot:
    index: 18
    item: Piga M
      type: Person
      first name: Matteo
      last name: Piga
      member of: Rheumatology Unit, University Clinic, AOU Cagliari, Cagliari, Italy.Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
  slot:
    index: 19
    item: Quartuccio L
      type: Person
      first name: Luca
      last name: Quartuccio
      member of: Rheumatology Unit, University of Udine, Department of Medicine, University Hospital Santa Maria della Misericordia, Udine, Italy.
  slot:
    index: 20
    item: Scirè CA
      type: Person
      first name: Carlo Alberto
      last name: Scirè
      member of: Epidemiology Unit, Italian Society of Rheumatology, Milan, Italy.School of Medicine, University of Milano Bicocca, Milan, Italy.
  slot:
    index: 21
    item: Tomietto P
      type: Person
      first name: Paola
      last name: Tomietto
      member of: Internal Medicine Department, Rheumatology Unit, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Trieste, Italy.
  slot:
    index: 22
    item: Truglia S
      type: Person
      first name: Simona
      last name: Truglia
      member of: Rheumatology Unit, University of Udine, Department of Medicine, University Hospital Santa Maria della Misericordia, Udine, Italy.
  slot:
    index: 23
    item: Zanetti A
      type: Person
      first name: Anna
      last name: Zanetti
      member of: Epidemiology Unit, Italian Society of Rheumatology, Milan, Italy.
  slot:
    index: 24
    item: Zen M
      type: Person
      first name: Margherita
      last name: Zen
      member of: Rheumatology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy.
  slot:
    index: 25
    item: Bertsias G
      type: Person
      first name: George
      last name: Bertsias
      member of: Department of Rheumatology, Clinical Immunology, University of Crete Medical School and University Hospital of Heraklion, Heraklion, Greece.Laboratory of Rheumatology, Autoimmunity and Inflammation, Infections & Immunity Division, Institute of Molecular Biology and Biotechnology (FORTH), Heraklion, Greece.
  slot:
    index: 26
    item: Govoni M
      type: Person
      first name: Marcello
      last name: Govoni
      member of: Section of Rheumatology, Department of Medical Sciences University of Ferrara and Azienda Ospedaliera-Universitaria di Ferrara, Cona, Italy.
created: 2024-2-25T12:42
date last updated: 2025-01-17
issued: 2024-10-01
dp: 2024 10 01
created: 2024-2-25T11:53
e ISSN: 1462-0332
has issn l: 1462-0324
issue: 10
has NLM journal title abbreviation: Rheumatology (Oxford)
publication name: Rheumatology (Oxford, England)
language: eng
has national library of medicine journal id: 100883501
derived from: NLM
starting page: 2711
ending page: 2720
has place of publication: England
has primary subject term: D020945Q000175Q000628
has primary subject term: D007166Q000627
has subject term: D006801
has subject term: D012189
has subject term: D005260
has subject term: D008297
has subject term: D000328
has subject term: D016896
has subject term: D008875
has subject term: D000305Q000627
has subject term: D012720
source: Rheumatology (Oxford). 2024-10-01;63(10):2711-2720.
volume: 63

Sequential multimodal treatments with chemotherapy and surgery for advanced soft tissue sarcoma may be associated with better survival than chemotherapy.
pmid: 38521760
abstract: In patients with advanced soft tissue sarcoma (STS), surgery had been reported to be associated with superior overall survival (OS). Chemotherapy details for such patients were less reported, and whether multimodal treatment with surgery and chemotherapy provides extra survival benefit remains unclear.We retrospectively reviewed patients with newly diagnosed advanced STS treated at National Taiwan University Hospital from January 1, 2011, to December 31, 2017. OS was calculated from the day of diagnosis of advanced STS to the day of death or last follow-up. Baseline patient characteristics and details regarding surgery and chemotherapy were recorded.A total of 545 patients were diagnosed with STS from 2011 to 2017, of which 226 patients had advanced STS. The median age was 54.7 years, and 54% of patients were women. Approximately 38% of patients with advanced STS underwent surgery and exhibited a trend of longer OS compared with who did not (median = 18.6 vs. 11.9 months, p = 0.083). In the chemotherapy subgroup, the benefit of surgery was more prominent (median = 21.9 vs. 16.5 months, p = 0.037). Patients who received chemotherapy prior to surgery exhibited numerically longer OS than those who underwent surgery first (median = 33.9 vs. 18.3 months, p = 0.155). After adjusting other clinical factors, chemotherapy remained an independent factor associated with favourable OS.Surgery may be more beneficial for the patients who receive chemotherapy. Our results support evaluation of sequential multimodal treatments strategy including surgery and chemotherapy in patients with advanced STS.
rights: Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.
has PII: S0929-6646(24)00152-9
doi: 10.1016/j.jfma.2024.03.007
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Chen CT
      type: Person
      first name: Ching-Tso
      last name: Chen
      member of: Department of Oncology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan, ROC; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC. Electronic address: robarroyce@gmail.com.
  slot:
    index: 2
    item: Chen HW
      type: Person
      first name: Hsing-Wu
      last name: Chen
      member of: Department of Oncology, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan, ROC; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC. Electronic address: hsingwuc@gmail.com.
  slot:
    index: 3
    item: Lin WH
      type: Person
      first name: Wei-Hsin
      last name: Lin
      member of: Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: ethanlin@ntuh.gov.tw.
  slot:
    index: 4
    item: Huang PM
      type: Person
      first name: Pei-Ming
      last name: Huang
      member of: Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: phuang3@ntuh.gov.tw.
  slot:
    index: 5
    item: Lin MW
      type: Person
      first name: Mong-Wei
      last name: Lin
      member of: Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: mwlin@ntu.edu.tw.
  slot:
    index: 6
    item: Yang CY
      type: Person
      first name: Ching-Yao
      last name: Yang
      member of: Department of Surgery, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan, ROC. Electronic address: cyang@ntuh.gov.tw.
  slot:
    index: 7
    item: Hsu CY
      type: Person
      first name: Che-Yu
      last name: Hsu
      member of: Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Department of Radiation Oncology, National Taiwan University Cancer Center, Taipei, Taiwan, ROC. Electronic address: codiwa@ntuh.gov.tw.
  slot:
    index: 8
    item: Wang CC
      type: Person
      first name: Chia-Chun
      last name: Wang
      member of: Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Department of Radiation Oncology, National Taiwan University Cancer Center, Taipei, Taiwan, ROC. Electronic address: chiachun@ntuh.gov.tw.
  slot:
    index: 9
    item: Lee JC
      type: Person
      first name: Jen-Chieh
      last name: Lee
      member of: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: leejenchieh@ntuh.gov.tw.
  slot:
    index: 10
    item: Chang K
      type: Person
      first name: Koping
      last name: Chang
      member of: Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: koping@ntuh.gov.tw.
  slot:
    index: 11
    item: Huang KH
      type: Person
      first name: Kuo-Hao
      last name: Huang
      member of: Department of Urology, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: khhuang@ntuh.gov.tw.
  slot:
    index: 12
    item: Chen HM
      type: Person
      first name: Ho-Min
      last name: Chen
      member of: Health Data Research Center, National Taiwan University, Taipei, Taiwan, ROC. Electronic address: homin.chen@gmail.com.
  slot:
    index: 13
    item: Chen TW
      type: Person
      first name: Tom Wei-Wu
      last name: Chen
      member of: Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan, ROC; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC. Electronic address: tomwchen@ntuh.gov.tw.
  slot:
    index: 14
    item: Yang RS
      type: Person
      first name: Rong-Sen
      last name: Yang
      member of: Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC. Electronic address: rsyang@ntuh.gov.tw.
  slot:
    index: 15
    item: Hong RL
      type: Person
      first name: Ruey-Long
      last name: Hong
      member of: Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, ROC; Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan, ROC. Electronic address: rlhong@ntuh.gov.tw.
created: 2024-3-24T00:42
date last updated: 2025-01-17
issued: 2025-01
dp: 2025 Jan
created: 2024-3-23T23:25
ISSN: 0929-6646
has issn l: 0929-6646
issue: 1
has NLM journal title abbreviation: J Formos Med Assoc
publication name: Journal of the Formosan Medical Association = Taiwan yi zhi
language: eng
has national library of medicine journal id: 9214933
derived from: NLM
starting page: 73
ending page: 78
has place of publication: Singapore
has primary subject term: D012509Q000188Q000401Q000473Q000601
has primary subject term: D020360Q000379Q000706
has primary subject term: D017024Q000379Q000706
has primary subject term: D000971Q000627
has subject term: D012189
has subject term: D053208
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D055815
has subject term: D000328
has subject term: D008875
has subject term: D000368
has subject term: D000369
has subject term: D060787
has subject term: D005500
source: J Formos Med Assoc. 2025-01;124(1):73-78.
volume: 124

The Impact of Wireless Emergency Alerts on a Floating Population in Seoul, South Korea: Panel Data Analysis.
pmid: 38526536
abstract: Wireless emergency alerts (WEAs), which deliver disaster information directly to individuals' mobile phones, have been widely used to provide information related to COVID-19 and to encourage compliance with social distancing guidelines during the COVID-19 pandemic. The floating population refers to the number of people temporarily staying in a specific area, and this demographic data can be a useful indicator to understand the level of social distancing people are complying with during the COVID-19 pandemic.This study aimed to empirically analyze the impact of WEAs on the floating population where WEAs were transmitted in the early stages of the COVID-19 pandemic. As most WEA messages focus on compliance with the government's social distancing guidelines, one of the goals of transmitting WEAs during the COVID-19 pandemic is to control the floating population at an appropriate level.We investigated the empirical impact of WEAs on the floating population across 25 districts in Seoul by estimating a panel regression model at the district-hour level with a series of fixed effects. The main independent variables were the number of instant WEAs, the daily cumulative number of WEAs, the total cumulative number of WEAs, and information extracted from WEAs by natural language processing at the district-hour level. The data set provided a highly informative empirical setting as WEAs were sent by different local governments with various identifiable district-hour-level data.The estimates of the impact of WEAs on the floating population were significantly negative (-0.013, P=.02 to -0.014, P=.01) across all specifications, implying that an additional WEA issuance reduced the floating population by 1.3% (=100(1-e-0.013)) to 1.4% (=100(1-e-0.014)). Although the coefficients of DCN (the daily cumulative number of WEAs) were also negative (-0.0034, P=.34 to -0.0052, P=.15) across all models, they were not significant. The impact of WEAs on the floating population doubled (-0.025, P[cell cut: 2883 characters, first 2000 kept]
rights: ©Sungwook Yoon, Hyungsoo Lim, Sungho Park. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 25.03.2024.
has PII: v10i1e43554
doi: 10.2196/43554
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Yoon S
      type: Person
      first name: Sungwook
      last name: Yoon
      member of: Korea Information Society Development Institute, Jincheon, Republic of Korea.
  slot:
    index: 2
    item: Lim H
      type: Person
      first name: Hyungsoo
      last name: Lim
      member of: Department of Information Systems, Business Statistics, and Operations Management, School of Business and Management, Hong Kong University of Science and Technology, Clear Water Bay, China (Hong Kong).
  slot:
    index: 3
    item: Park S
      type: Person
      first name: Sungho
      last name: Park
      member of: Business School, Seoul National University, Seoul, Republic of Korea.
created: 2024-3-25T12:44
date last updated: 2025-01-17
issued: 2024-03-25
dp: 2024 03 25
created: 2024-3-25T11:53
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e43554
has place of publication: Canada
has primary subject term: D058873Q000517
has primary subject term: D000086382Q000453
has subject term: D006801
has subject term: D066106Q000453
has subject term: D056910Q000453
has subject term: http://id.nlm.nih.gov/mesh/D000078332
source: JMIR Public Health Surveill. 2024-03-25;10():e43554.
volume: 10

Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Latin America and the Caribbean: Longitudinal Trend Analysis.
pmid: 38568194
abstract: In May 2020, the World Health Organization (WHO) declared Latin America and the Caribbean (LAC) the epicenter of the COVID-19 pandemic, with over 40% of worldwide COVID-19-related deaths at the time. This high disease burden was a result of the unique circumstances in LAC.This study aimed to (1) measure whether the pandemic was expanding or contracting in LAC when the WHO declared the end of COVID-19 as a public health emergency of international concern on May 5, 2023; (2) use dynamic and genomic surveillance methods to describe the history of the pandemic in the region and situate the window of the WHO declaration within the broader history; and (3) provide, with a focus on prevention policies, a historical context for the course of the pandemic in the region.In addition to updates of traditional surveillance data and dynamic panel estimates from the original study, we used data on sequenced SARS-CoV-2 variants from the Global Initiative on Sharing All Influenza Data (GISAID) to identify the appearance and duration of variants of concern (VOCs). We used Nextclade nomenclature to collect clade designations from sequences and Pangolin nomenclature for lineage designations of SARS-CoV-2. Additionally, we conducted a 1-sided t test for whether the regional weekly speed (rate of novel COVID-19 transmission) was greater than an outbreak threshold of 10. We ran the test iteratively with 6 months of data across the period from August 2020 to May 2023.The speed of pandemic spread for the region had remained below the outbreak threshold for 6 months by the time of the WHO declaration. Acceleration and jerk were also low and stable. Although the 1- and 7-day persistence coefficients remained statistically significant for the 120-day period ending on the week of May 5, 2023, the coefficients were relatively modest in magnitude (0.457 and 0.491, respectively). Furthermore, the shift parameters for either of the 2 most recent weeks around May 5, 2023, did not indicate any change[cell cut: 2724 characters, first 2000 kept]
rights: ©Lori Ann Post, Scott A Wu, Alan G Soetikno, Egon A Ozer, Yingxuan Liu, Sarah B Welch, Claudia Hawkins, Charles B Moss, Robert L Murphy, Maryann Mason, Robert J Havey, Alexander L Lundberg. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 17.05.2024.
has PII: v10i1e44398
doi: 10.2196/44398
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Post LA
      type: Person
      first name: Lori Ann
      last name: Post
      member of: Buehler Center for Health Policy and Economics, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 2
    item: Wu SA
      type: Person
      first name: Scott A
      last name: Wu
      member of: Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 3
    item: Soetikno AG
      type: Person
      first name: Alan G
      last name: Soetikno
      member of: Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 4
    item: Ozer EA
      type: Person
      first name: Egon A
      last name: Ozer
      member of: Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.Center for Pathogen Genomics and Microbial Evolution, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.
  slot:
    index: 5
    item: Liu Y
      type: Person
      first name: Yingxuan
      last name: Liu
      member of: Buehler Center for Health Policy and Economics, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 6
    item: Welch SB
      type: Person
      first name: Sarah B
      last name: Welch
      member of: Buehler Center for Health Policy and Economics, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 7
    item: Hawkins C
      type: Person
      first name: Claudia
      last name: Hawkins
      member of: Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.Center for Global Communicable and Emerging Infectious Diseases, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.
  slot:
    index: 8
    item: Moss CB
      type: Person
      first name: Charles B
      last name: Moss
      member of: Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United States.
  slot:
    index: 9
    item: Murphy RL
      type: Person
      first name: Robert L
      last name: Murphy
      member of: Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.
  slot:
    index: 10
    item: Mason M
      type: Person
      first name: Maryann
      last name: Mason
      member of: Buehler Center for Health Policy and Economics, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 11
    item: Havey RJ
      type: Person
      first name: Robert J
      last name: Havey
      member of: Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.Department of Medicine, General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
  slot:
    index: 12
    item: Lundberg AL
      type: Person
      first name: Alexander L
      last name: Lundberg
      member of: Buehler Center for Health Policy and Economics, Robert J Havey, MD Institute for Global Health, Northwestern University, Chicago, IL, United States.Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
created: 2024-4-3T12:49
date last updated: 2025-01-17
issued: 2024-05-17
dp: 2024 05 17
created: 2024-4-3T10:52
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e44398
has place of publication: Canada
has primary subject term: D000086382Q000453
has subject term: D006801
has subject term: D017691Q000453
has subject term: D007843Q000453
has subject term: D008137
has subject term: D058873
has subject term: http://id.nlm.nih.gov/mesh/D000086402
source: JMIR Public Health Surveill. 2024-05-17;10():e44398.
volume: 10

Finding meaning in medication.
pmid: 38573673
abstract: The author reflects on a decade of antipsychotic treatment, providing an intimate glimpse into living with schizophrenia. Their narrative unravels the balance of vulnerability and strength, coercion, and dialogue inherent in the acceptance of medication. Their journey from defiance to adherence showcases the profound complexities patients face and the ethical dilemmas confronting caregivers. Interactions with loved ones and mentors underscore the importance of a shared decision-making approach. The author emphasizes not just the significance of medication but the broader, holistic perspective of aligning treatment with one's life goals and values. Their story champions the power of lived experiences, aiming to inspire a more empathetic and collaborative approach to antipsychotic treatment. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2024-69630-001
doi: 10.1037/prj0000611
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Larrauri CA
      type: Person
      first name: Carlos A
      last name: Larrauri
      member of: University of Michigan Law School.
created: 2024-4-4T12:45
date last updated: 2025-01-17
issued: 2024-12
dp: 2024 Dec
created: 2024-4-4T11:43
e ISSN: 1559-3126
has issn l: 1095-158X
issue: 4
has NLM journal title abbreviation: Psychiatr Rehabil J
publication name: Psychiatric rehabilitation journal
language: eng
has national library of medicine journal id: 9601800
derived from: NLM
starting page: 339
ending page: 341
has place of publication: United States
has primary subject term: D012559Q000188
has primary subject term: D014150Q000627
has primary subject term: D055118
has subject term: D006801
has subject term: D000328
source: Psychiatr Rehabil J. 2024-12;47(4):339-341.
volume: 47

Navigating the straits of deprescribing: Psychiatrist's personal account of fears and hopes.
pmid: 38573670
abstract: Deprescribing is a long-overdue concept for psychiatrists and therapists, presenting potentially more sophisticated approaches to psychiatric care. This approach is fueled by both scientific pursuits and contemporary social ideologies that underscore the pivotal role of a patient's values and their freedom of choice. Indeed, deprescribing is well woven with modern liberal and progressive values. Yet, amidst the emphasis on these aspects, it is crucial not to lose sight of the conservative perspective within this discourse-one that emphasizes the potential consequences of failure. While constantly addressing relapse as a looming cloud may not yield benefits for patients, overlooking these potential pitfalls could tip the balance too far, resulting in unintended harm rather than good. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2024-70103-001
doi: 10.1037/prj0000610
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Segev A
      type: Person
      first name: Aviv
      last name: Segev
      member of: Shalvata Mental Health Center.
created: 2024-4-4T12:48
date last updated: 2025-01-17
issued: 2024-12
dp: 2024 Dec
created: 2024-4-4T11:43
e ISSN: 1559-3126
has issn l: 1095-158X
issue: 4
has NLM journal title abbreviation: Psychiatr Rehabil J
publication name: Psychiatric rehabilitation journal
language: eng
has national library of medicine journal id: 9601800
derived from: NLM
starting page: 351
ending page: 353
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000069340
has primary subject term: D011570
has subject term: D006801
has subject term: D005239
has subject term: D065026
has subject term: D001523Q000188
has subject term: http://id.nlm.nih.gov/mesh/D000096244
source: Psychiatr Rehabil J. 2024-12;47(4):351-353.
volume: 47

Development and characterization of ceramic-polymeric hybrid scaffolds for bone regeneration: incorporating of bioactive glass BG-58S into PDLLA matrix.
pmid: 38569077
abstract: In recent years, there has been a notable surge of interest in hybrid materials within the biomedical field, particularly for applications in bone repair and regeneration. Ceramic-polymeric hybrid scaffolds have shown promising outcomes. This study aimed to synthesize bioactive glass (BG-58S) for integration into a bioresorbable polymeric matrix based on PDLLA, aiming to create a bioactive scaffold featuring stable pH levels. The synthesis involved a thermally induced phase separation process followed by lyophilization to ensure an appropriate porous structure. BG-58S characterization revealed vitreous, bioactive, and mesoporous structural properties. The scaffolds were analyzed for morphology, interconnectivity, chemical groups, porosity and pore size distribution, zeta potential, pH, in vitro degradation, as well as cell viability tests, total protein content and mineralization nodule production. The PDLLA scaffold displayed a homogeneous morphology with interconnected macropores, while the hybrid scaffold exhibited a heterogeneous morphology with smaller diameter pores due to BG-58S filling. The hybrid scaffold also demonstrated a pH buffering effect on the polymer surface. In addition to structural characteristics, degradation tests indicated that by incorporating BG-58S modified the acidic degradation of the polymer, allowing for increased total protein production and the formation of mineralization nodules, indicating a positive influence on cell culture.
doi: 10.1080/09205063.2024.2334981
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Aguiar VCPF
      type: Person
      first name: Veronica Cristina Pêgo Fiebig
      last name: Aguiar
      member of: Characterization and Processing Laboratory of Advanced Materials, Institute for Research and Development, University of Vale do Paraíba, São Paulo, Brazil.
  slot:
    index: 2
    item: Bezerra RDN
      type: Person
      first name: Rayssa do Nascimento
      last name: Bezerra
      member of: Selaz - Industry and Commercialization of Biomechanical Devices, São Paulo, Brazil.
  slot:
    index: 3
    item: Dos Santos KW
      type: Person
      first name: Kennedy Wallace
      last name: Dos Santos
      member of: Characterization and Processing Laboratory of Advanced Materials, Institute for Research and Development, University of Vale do Paraíba, São Paulo, Brazil.Selaz - Industry and Commercialization of Biomechanical Devices, São Paulo, Brazil.
  slot:
    index: 4
    item: Gonçalves IDS
      type: Person
      first name: Isabela Dos Santos
      last name: Gonçalves
      member of: Characterization and Processing Laboratory of Advanced Materials, Institute for Research and Development, University of Vale do Paraíba, São Paulo, Brazil.
  slot:
    index: 5
    item: Costa KJSG
      type: Person
      first name: Karen Julie Santos Grancianinov
      last name: Costa
      member of: Selaz - Industry and Commercialization of Biomechanical Devices, São Paulo, Brazil.
  slot:
    index: 6
    item: Lauda DP
      type: Person
      first name: Diogo Ponte
      last name: Lauda
      member of: Selaz - Industry and Commercialization of Biomechanical Devices, São Paulo, Brazil.
  slot:
    index: 7
    item: Campos TMB
      type: Person
      first name: Tiago Moreira Bastos
      last name: Campos
      member of: Laboratório de Plasma e Processos, Instituto Tecnológico de Aeronáutica. Laboratório, São José dos Campos. Praça Marechal Eduardo Gomes, CEP, Brasil.
  slot:
    index: 8
    item: do Prado RF
      type: Person
      first name: Renata Falchete
      last name: do Prado
      member of: Institute of Science and Technology, Paulista State University, Francisco José Longo, São José dos Campos, SP, CEP, Brazil.
  slot:
    index: 9
    item: de Vasconcellos LMR
      type: Person
      first name: Luana Marotta Reis
      last name: de Vasconcellos
      member of: Institute of Science and Technology, Paulista State University, Francisco José Longo, São José dos Campos, SP, CEP, Brazil.
  slot:
    index: 10
    item: de Oliveira IR
      type: Person
      first name: Ivone Regina
      last name: de Oliveira
      member of: Characterization and Processing Laboratory of Advanced Materials, Institute for Research and Development, University of Vale do Paraíba, São Paulo, Brazil.
created: 2024-4-3T18:44
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-3T14:43
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1493
ending page: 1510
has place of publication: England
has primary subject term: D002516Q000737
has primary subject term: D054457Q000737
has primary subject term: D001861Q000187
has primary subject term: D005898Q000737
has primary subject term: D011091Q000737
has subject term: D016062
has subject term: D001672Q000737
has subject term: D006863
has subject term: D006801
has subject term: D002470Q000187
has subject term: D008422
source: J Biomater Sci Polym Ed. 2024-07;35(10):1493-1510.
volume: 35

Ambulatory blood pressure monitoring profiles in Asia.
pmid: 38563647
abstract: High blood pressure (BP) remains a major health problem globally, with a proportion of hypertension-mediated organ damage (HMOD) increasing worldwide including in Asia region. Cardiovascular (CV), cerebral and kidney diseases related to hypertension were reported to be closely associated with morning surge and nocturnal hypertension-a subset of BP variability-which can be detected by out-of-office BP measurement. Ambulatory BP monitoring (ABPM) and Home BP monitoring (HBPM) have been recommended by major guidelines to be used in the evaluation of BP variability and outcomes' prediction of hypertension patients. However, an interesting profile of ABPM in Asia has been reported and hypothesized to correlate with different outcomes. This review will focus on the current recommendation of ABPM use by the guidelines, the major different profiles of ABPM in Asia as compared to Western countries according to clinical indications, and the challenges in implementing optimal use of ABPM in Asian countries based on available evidence.
rights: © 2024 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
doi: 10.1111/jch.14799
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Widyantoro B
      type: Person
      first name: Bambang
      last name: Widyantoro
      member of: Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
  slot:
    index: 2
    item: Nailes JM
      type: Person
      first name: Jennifer M
      last name: Nailes
      member of: Department of Preventive and Community Medicine, University of the East Ramon Magsaysay Memorial Medical Center Research Institute for Health Sciences, Manila, Philippines.
  slot:
    index: 3
    item: Sukonthasarn A
      type: Person
      first name: Apichard
      last name: Sukonthasarn
      member of: Cardiovascular Division, Department of Medicine, Faculty of Medicine Chiang Mai University, Chiang Mai, Thailand.
  slot:
    index: 4
    item: Soenarta AA
      type: Person
      first name: Arieska Ann
      last name: Soenarta
      member of: Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
creator: HOPE Asia Network
created: 2024-4-2T12:45
date last updated: 2025-01-17
issued: 2024-12
dp: 2024 Dec
created: 2024-4-2T09:43
e ISSN: 1751-7176
has issn l: 1524-6175
issue: 12
has NLM journal title abbreviation: J Clin Hypertens (Greenwich)
publication name: Journal of clinical hypertension (Greenwich, Conn.)
language: eng
has national library of medicine journal id: 100888554
derived from: NLM
starting page: 1362
ending page: 1367
has place of publication: United States
has primary subject term: D018660Q000379
has primary subject term: D006973Q000175Q000453Q000503
has primary subject term: D002940Q000502
has subject term: D006801
has subject term: D001208Q000453
has subject term: D001794Q000502
has subject term: D002318Q000453Q000175
has subject term: D017410
source: J Clin Hypertens (Greenwich). 2024-12;26(12):1362-1367.
volume: 26

Awakening on antipsychotic medication: A call to action.
pmid: 38573672
abstract: Explore a lived experience perspective on using antipsychotic medicine and call to action for psychiatric rehabilitation practitioners to get involved in preparing people diagnosed with serious mental illness (SMI) to have a voice and choice in antipsychotic medication treatment.A first-person account of awakening on an antipsychotic medication for the first time is used to understand the lived experience and challenges of using it. Lessons learned are amplified through de-identified queries of the CommonGround database capturing concerns about antipsychotic medication of people diagnosed with SMI in public sector mental health clinics in the United States.Lived experience of me-on-medicine included embodied and perceptual changes to self when taking antipsychotic medications. Discordance between the team's goal and personal goals for medication treatment interfered with recovery. Analysis of more than 100,000 concerns about antipsychotic medications expressed by 57,370 CommonGround users showed the most frequent concerns are that medication is perceived as unhelpful (21%), side effects (13%), impact on health (12%), and concerns about feeling unmotivated to use medication (8%). Among CommonGround users below age 30, low motivation to take antipsychotics was the third most prevalent concern. Among CommonGround users over age 30, concerns about the impact on health were the third most dominant.Psychiatric rehabilitation practitioners can support people diagnosed with SMI getting prepared to participate in decision making about antipsychotic medications with psychiatric care providers by identifying concerns and building skills and strategies to negotiate the new me-on-medicine. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2024-70347-001
doi: 10.1037/prj0000608
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Deegan PE
      type: Person
      first name: Patricia E
      last name: Deegan
      member of: Pat Deegan and Associates, LLC.
  slot:
    index: 2
    item: Stiles A
      type: Person
      first name: Allison
      last name: Stiles
      member of: Pat Deegan and Associates, LLC.
  slot:
    index: 3
    item: Rufo M
      type: Person
      first name: Missy
      last name: Rufo
      member of: Pat Deegan and Associates, LLC.
  slot:
    index: 4
    item: Zisman-Ilani Y
      type: Person
      first name: Yaara
      last name: Zisman-Ilani
      member of: Department of Social and Behavioral Sciences, College of Public Health, Temple University.
created: 2024-4-4T12:48
date last updated: 2025-01-17
issued: 2024-12
dp: 2024 Dec
created: 2024-4-4T11:43
e ISSN: 1559-3126
has issn l: 1095-158X
issue: 4
has NLM journal title abbreviation: Psychiatr Rehabil J
publication name: Psychiatric rehabilitation journal
language: eng
has national library of medicine journal id: 9601800
derived from: NLM
starting page: 283
ending page: 290
has place of publication: United States
has primary subject term: D014150
has subject term: D006801
has subject term: D000328
has subject term: D008297
has subject term: D005260
has subject term: http://id.nlm.nih.gov/mesh/D000067250
has subject term: D001523Q000188Q000534
has subject term: D008875
has subject term: D014481
source: Psychiatr Rehabil J. 2024-12;47(4):283-290.
volume: 47

Acute proximal weakness and paraesthesiae.
pmid: 38580432
has PII: pn-2023-004082
doi: 10.1136/pn-2023-004082
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Maure Blesa L
      type: Person
      first name: Lucia
      last name: Maure Blesa
      member of: Neurology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain luciamaure.lm@gmail.com.
  slot:
    index: 2
    item: López de Mota Sánchez D
      type: Person
      first name: Daniel
      last name: López de Mota Sánchez
      member of: Neurology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
  slot:
    index: 3
    item: Álvarez-Toledo O
      type: Person
      first name: Olalla
      last name: Álvarez-Toledo
      member of: Internal Medicine Department, Hospital FREMAP Majadahonda, Madrid, Spain.
  slot:
    index: 4
    item: Montes Fernandez E
      type: Person
      first name: Elena
      last name: Montes Fernandez
      member of: Neurophysiology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
  slot:
    index: 5
    item: Morales Conejo M
      type: Person
      first name: Montserrat
      last name: Morales Conejo
      member of: Internal Medicine Department, Hospital Universitario Doce de Octubre, Madrid, Comunidad de Madrid, Spain.
  slot:
    index: 6
    item: Díaz-Cardona T
      type: Person
      first name: Teresa
      last name: Díaz-Cardona
      member of: Rehabilitation Centre, Hospital FREMAP Majadahona, Madrid, Spain.
  slot:
    index: 7
    item: Olivie Garcia L
      type: Person
      first name: Laura
      last name: Olivie Garcia
      member of: Neurology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
  slot:
    index: 8
    item: Zamarbide Capdepon I
      type: Person
      first name: Ivana
      last name: Zamarbide Capdepon
      member of: Neurology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
  slot:
    index: 9
    item: Herranz Bárcenas A
      type: Person
      first name: Antonio
      last name: Herranz Bárcenas
      member of: Neurology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
created: 2024-4-6T00:42
date last updated: 2025-01-17
issued: 2025-01-16
dp: 2025 Jan 16
created: 2024-4-5T21:03
e ISSN: 1474-7766
has issn l: 1474-7758
issue: 1
has NLM journal title abbreviation: Pract Neurol
publication name: Practical neurology
language: eng
has national library of medicine journal id: 101130961
derived from: NLM
starting page: 87
ending page: 92
has place of publication: England
source: Pract Neurol. 2025-01-16;25(1):87-92.
volume: 25

Production and characterization of polyvinyl alcohol films containing essential oil.
pmid: 38588607
abstract: Packaging plays an important role in protecting foodstuffs against physicochemical damage and microbial activity, as well as extending shelf life. In recent years, petrochemical compounds that cause environmental pollution and contamination due to their non-biodegradability have been replaced by biocompatible polymer-based films in the food packaging industry. Due to aromatic essential oils (EO), various biological activities, and their potential to replace chemical preservatives in the field of food preservation, Star Anise essential oil, which has properties, such as free radical scavenger, antibacterial, antifungal and antiviral, was used as an additive in this study. Biodegradable and biocompatible polyvinyl alcohol (PVA) polymer was used as the matrix and polymer-based films were produced in 3 different concentrations. Spectral analysis, structural, chemical, and thermal characterizations, and surface morphologies of the produced films by the direct incorporation method were examined. In addition, the antibacterial activities of the films on Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 25922, and Acinetobacter baumannii ATCC BAA 747 bacteria were investigated. As a result of the examinations, it was determined that an interfacial interaction occurred between the matrix and the filler, and the produced films were thermally resistant and showed antibacterial activity against Gram (+)/Gram (-) bacteria. Consequently, it can be concluded that PVA films containing Star Anise essential oil present a prospective substitute in a variety of industrial packaging systems, including those for food, medicine, and cosmetics.
doi: 10.1080/09205063.2024.2338642
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ünlü N
      type: Person
      first name: Nihan
      last name: Ünlü
      member of: Department of Medical Services and Techniques, Vocational School of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey.
  slot:
    index: 2
    item: Özgen A
      type: Person
      first name: Arzu
      last name: Özgen
      member of: Department of Medical Services and Techniques, Vocational School of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey.
  slot:
    index: 3
    item: Aksu Canbay C
      type: Person
      first name: Canan
      last name: Aksu Canbay
      member of: Department of Physics, Faculty of Science, Firat University, Elazig, Turkey.
created: 2024-4-9T00:42
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-8T18:13
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1537
ending page: 1549
has place of publication: England
has primary subject term: D011142Q000737
has primary subject term: D009822Q000737Q000494
has primary subject term: D000900Q000494Q000737
has primary subject term: D018857
has subject term: D013212Q000187
has subject term: D004926Q000187
has subject term: D008826
has subject term: D040981Q000187
source: J Biomater Sci Polym Ed. 2024-07;35(10):1537-1549.
volume: 35

Impact of changes in collagen construction and molecular state on integrin - binding properties.
pmid: 38574261
abstract: The interaction between the integrin and collagen is important in cell adhesion and signaling. Collagen, as the main component of extracellular matrix, is a base material for tissue engineering constructs. In tissue engineering, the collagen structure and molecule state may be altered to varying degrees in the process of processing and utilizing, thereby affecting its biological properties. In this work, the impact of changes in collagen structure and molecular state on the binding properties of collagen to integrin α2β1 and integrin specific cell adhesion were explored. The results showed that the molecular structure of collagen is destroyed under the influence of heating, freeze-grinding and irradiation, the triple helix integrity is reduced and molecular breaking degree is increased. The binding ability of collagen to integrin α2β1 is increased with the increase of triple helix integrity and decays exponentially with the increase of molecular breaking degree. The collagen molecular state can also influences the binding ability of collagen to cellular receptor. The collagen fibrils binding to integrin α2β1 and HT1080 cells is stronger than to collagen monomolecule. Meanwhile, the hybrid fibril exhibits a different cellular receptor binding performance from corresponding single species collagen fibril. These findings provide ideas for the design and development of new collagen-based biomaterials and tissue engineering research.
doi: 10.1080/09205063.2024.2338004
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Kou H
      type: Person
      first name: Huizhi
      last name: Kou
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
  slot:
    index: 2
    item: Han Q
      type: Person
      first name: Qingqiu
      last name: Han
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
  slot:
    index: 3
    item: Zhang H
      type: Person
      first name: Huihui
      last name: Zhang
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
  slot:
    index: 4
    item: Xu C
      type: Person
      first name: Chengzhi
      last name: Xu
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
  slot:
    index: 5
    item: Liao L
      type: Person
      first name: Lixia
      last name: Liao
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
  slot:
    index: 6
    item: Hou Y
      type: Person
      first name: Yuanjing
      last name: Hou
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
  slot:
    index: 7
    item: Wang H
      type: Person
      first name: Haibo
      last name: Wang
      member of: College of Life Science and Technology, Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University, Xiaogan, China.
  slot:
    index: 8
    item: Zhang J
      type: Person
      first name: Juntao
      last name: Zhang
      member of: School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan, China.
created: 2024-4-4T18:43
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-4T15:12
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1523
ending page: 1536
has place of publication: England
has primary subject term: D038982Q000378Q000737
has primary subject term: D003094Q000737Q000378
has primary subject term: D002448
has primary subject term: D011485
has subject term: D006801
has subject term: D001672Q000737Q000378
has subject term: D000818
has subject term: D023822Q000379
has subject term: D045744
source: J Biomater Sci Polym Ed. 2024-07;35(10):1523-1536.
volume: 35

Self-assembling peptide hydrogel scaffold integrating stem cell-derived exosomes for infected bone defects.
pmid: 38574263
abstract: Infected bone defect (IBD) is a great challenge in orthopedics, which involves in bone loss and infection. Here, a self-assembling hydrogel scaffold (named AMP-RAD/EXO), integrating antimicrobial peptides(AMPs), RADA16 and BMSCs exosomes with an innovative strategy, is developed and applied in IBD treatment for sustained antimicrobial ability, accelerating osteoblasts proliferation and promoting bone regeneration. AMPs present an excellent ability to inhibit infection, RADA16 is a self-assembling peptide hydrogel for AMPs delivery, and BMSCs exosomes can promote the bone regeneration. The prepared AMP-RAD/EXO exhibited a polyporous 3D structure for imbibition of BMSCs exosomes and migration of osteoblasts. In vitro studies indicate AMP-RAD/EXO can inhibit the growth of Staphylococcus aureus, accelerate the proliferation and migration of BMSCs. More importantly, in vivo results also prove that AMP-RAD/EXO exhibit an excellent effect on IBD treatment. Thus, the prepared AMP-RAD/EXO provides a multifunctional scaffold concept for bone tissue engineering technology.
doi: 10.1080/09205063.2024.2336316
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Xu H
      type: Person
      first name: Haiyan
      last name: Xu
      member of: Orthopaedics, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
  slot:
    index: 2
    item: Feng J
      type: Person
      first name: Jing
      last name: Feng
      member of: Nursing Department, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
  slot:
    index: 3
    item: Dai N
      type: Person
      first name: Ning
      last name: Dai
      member of: Nursing Department, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
  slot:
    index: 4
    item: Han Q
      type: Person
      first name: Qiong
      last name: Han
      member of: Orthopaedics, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
  slot:
    index: 5
    item: Zhou B
      type: Person
      first name: Bei
      last name: Zhou
      member of: Nursing Department, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
  slot:
    index: 6
    item: Yang G
      type: Person
      first name: Guiyun
      last name: Yang
      member of: Nursing Department, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
  slot:
    index: 7
    item: Hu R
      type: Person
      first name: Rui
      last name: Hu
      member of: Orthopaedics, Wuhan Fourth Hospital, Wuhan, Hubei Province, P.R. China.
created: 2024-4-4T18:43
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-4T15:12
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1511
ending page: 1522
has place of publication: England
has primary subject term: D020100Q000737
has primary subject term: D055354Q000737
has primary subject term: D054457Q000737
has primary subject term: D013211Q000187Q000502
has primary subject term: D001861Q000187
has subject term: D000818
has subject term: D049109Q000187
has subject term: D000089882Q000737Q000494
has subject term: D002465Q000187
has subject term: D059630Q000166
has subject term: D010006Q000166Q000187
has subject term: D023822
has subject term: D001842
source: J Biomater Sci Polym Ed. 2024-07;35(10):1511-1522.
volume: 35

Sex Differences in Delirium after Coronary Artery Bypass Graft Surgery and Perioperative Neuropsychiatric Conditions: A Secondary Analysis of a Cohort Study.
pmid: 38604978
abstract: Biological sex influences the risk of depression and cognitive impairment, but its role in relation to postoperative delirium is unclear. This analysis investigates sex differences in delirium risk after coronary artery bypass graft (CABG) surgery and sex-related differences in relation to affective and cognitive symptoms.This is a secondary analysis of the Neuropsychiatric Outcomes After Heart Surgery (NOAHS) study, a single-site, observational study of a CABG surgery cohort (n = 149). Preoperative characteristics are stratified by sex, and baseline variables that differ by sex are evaluated to understand whether sex modifies their relationships with delirium. We also evaluate sex differences in one-month depression and cognition.Female sex is associated with several delirium risk factors, including higher risk of preoperative depression and middle cerebral artery (MCA) stenosis. MCA stenosis was statistically associated with delirium only among women (OR 15.6, 95% CI 1.5, 164.4); mild cognitive impairment (MCI) was associated with delirium only in men (OR 4.6, 95% CI 1.2, 17.9). Other sex-based differences failed to reach statistical significance. Depression remained commoner among women 1 month post-CABG.Women in this CABG cohort were more likely to have depression at baseline and 1 month postoperatively, as well as MCA stenosis and postoperative delirium. Sex might modify the relationship between post-CABG delirium and its risk factors including MCA stenosis and MCI. Cerebrovascular disease deserves study as a potential explanation linking female sex and a range of poor outcomes among women with coronary heart disease.
doi: 10.1177/08919887241246226
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Oldham MA
      type: Person
      first name: Mark A
      last name: Oldham
      member of: Department of Psychiatry University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 2
    item: Kukla B
      type: Person
      first name: Bennett
      last name: Kukla
      member of: College of Arts and Sciences, Cornell University, Ithaca, NY, USA.
  slot:
    index: 3
    item: Walsh P
      type: Person
      first name: Patrick
      last name: Walsh
      member of: Department of Psychiatry University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 4
    item: Lee HB
      type: Person
      first name: Hochang B
      last name: Lee
      member of: Department of Psychiatry University of Rochester Medical Center, Rochester, NY, USA.
created: 2024-4-12T00:43
date last updated: 2025-01-17
issued: 2024-11
dp: 2024 Nov
created: 2024-4-11T22:54
ISSN: 0891-9887
has issn l: 0891-9887
issue: 6
has NLM journal title abbreviation: J Geriatr Psychiatry Neurol
publication name: Journal of geriatric psychiatry and neurology
language: eng
has national library of medicine journal id: 8805645
derived from: NLM
starting page: 473
ending page: 481
has place of publication: United States
has primary subject term: D001026Q000009
has primary subject term: D003693Q000209Q000453
has primary subject term: D011183Q000453Q000523
has primary subject term: D060825Q000209
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000368
has subject term: D008875
has subject term: D015331
has subject term: D012307
has subject term: D003863Q000453
has subject term: D012737
has subject term: D012727
source: J Geriatr Psychiatry Neurol. 2024-11;37(6):473-481.
volume: 37

Incidence, predictors, and outcomes of malignant cerebral edema in acute basilar artery occlusion after endovascular treatment: a secondary analysis of the ATTENTION trial.
pmid: 38579342
abstract: Malignant cerebral edema (MCE) is a life-threatening complication of ischemic stroke. Few studies have evaluated MCE in patients with acute basilar artery occlusion (BAO) receiving endovascular treatment (EVT). Therefore, the authors investigated the incidence, predictors, and functional outcomes of MCE in BAO patients undergoing EVT.This was a post hoc analysis of the Endovascular Treatment for Acute Basilar Artery Occlusion (ATTENTION) trial, a prospective, randomized, multicenter clinical trial that compared endovascular treatment with conventional care of patients with BAO at 36 centers in China. Brain edema was retrospectively assessed using the Jauss score for all available follow-up scans, and patients with a Jauss score ≥ 4 were classified as having MCE. Clinical functional independence was defined as a modified Rankin Scale (mRS) score of 0-2, and a good outcome was defined as an mRS score of 0-3 at the 90-day follow-up. Univariate and multivariate analyses were used to explore the predictors of MCE and the impact of MCE on prognosis.A total of 189 patients were analyzed, and 13.2% of patients developed MCE. Multivariate analysis showed that the baseline Glasgow Coma Scale (GCS) score (OR 0.722, 95% CI 0.548-0.950; p = 0.020) and the number of procedures (OR 1.594, 95% CI 1.051-2.419; p = 0.028) were significantly associated with MCE. After adjusting for confounding factors, the presence of MCE was significantly associated with a lower rate of functional independence (OR 0.115, 95% CI 0.023-0.563; p = 0.008), a lower rate of good outcome (OR 0.092, 95% CI 0.023-0.360; p = 0.001), and a higher rate of mortality (OR 5.373, 95% CI 2.055-14.052; p = 0.001) at the 90-day follow-up.MCE is not uncommon in BAO patients undergoing EVT and is associated with poor outcomes. Baseline GCS score and the number of procedures were predictors of MCE. In clinical practice, it is crucial that physicians identifying MCE after EVT in patients with BAO and identification of MCE [cell cut: 2101 characters, first 2000 kept]
doi: 10.3171/2024.1.JNS232085
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Huang X
      type: Person
      first name: Xianjun
      last name: Huang
      member of: 1Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
  slot:
    index: 2
    item: Wang H
      type: Person
      first name: Hao
      last name: Wang
      member of: 2Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China.
  slot:
    index: 3
    item: Ji Y
      type: Person
      first name: Yachen
      last name: Ji
      member of: 1Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
  slot:
    index: 4
    item: Tao C
      type: Person
      first name: Chunrong
      last name: Tao
      member of: 3Stroke Center & Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; and.
  slot:
    index: 5
    item: Shang X
      type: Person
      first name: Xianjin
      last name: Shang
      member of: 1Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
  slot:
    index: 6
    item: Ni C
      type: Person
      first name: Chuyuan
      last name: Ni
      member of: 4Department of Neurology, Huangshan City People's Hospital, Huangshan, Anhui, China.
  slot:
    index: 7
    item: Xu J
      type: Person
      first name: Junfeng
      last name: Xu
      member of: 1Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
  slot:
    index: 8
    item: Xu X
      type: Person
      first name: Xiangjun
      last name: Xu
      member of: 1Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
  slot:
    index: 9
    item: Hu W
      type: Person
      first name: Wei
      last name: Hu
      member of: 3Stroke Center & Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; and.
  slot:
    index: 10
    item: Zhou Z
      type: Person
      first name: Zhiming
      last name: Zhou
      member of: 1Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, China.
created: 2024-4-5T18:42
date last updated: 2025-01-17
issued: 2024-10-01
dp: 2024 Oct 01
created: 2024-4-5T17:53
e ISSN: 1933-0693
has issn l: 0022-3085
issue: 4
has NLM journal title abbreviation: J Neurosurg
publication name: Journal of neurosurgery
language: eng
has national library of medicine journal id: 0253357
derived from: NLM
starting page: 1011
ending page: 1019
has place of publication: United States
has primary subject term: D057510
has primary subject term: D001929Q000209Q000453
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D008875
has subject term: D000368
has subject term: D015994
has subject term: D016896
has subject term: D014715Q000601Q000150
has subject term: D011446
has subject term: D011183Q000453Q000209
has subject term: D002681Q000453
has subject term: D012189
has subject term: D015600
source: J Neurosurg. 2024-10-01;141(4):1011-1019.
volume: 141

Microfluidics-Based Technologies for the Assessment of Castration-Resistant Prostate Cancer.
pmid: 38607014
abstract: Castration-resistant prostate cancer remains a significant clinical challenge, wherein patients display no response to existing hormone therapies. The standard of care often includes aggressive treatment options using chemotherapy, radiation therapy and various drugs to curb the growth of additional metastases. As such, there is a dire need for the development of innovative technologies for both its diagnosis and its management. Traditionally, scientific exploration of prostate cancer and its treatment options has been heavily reliant on animal models and two-dimensional (2D) in vitro technologies. However, both laboratory tools often fail to recapitulate the dynamic tumor microenvironment, which can lead to discrepancies in drug efficacy and side effects in a clinical setting. In light of the limitations of traditional animal models and 2D in vitro technologies, the emergence of microfluidics as a tool for prostate cancer research shows tremendous promise. Namely, microfluidics-based technologies have emerged as powerful tools for assessing prostate cancer cells, isolating circulating tumor cells, and examining their behaviour using tumor-on-a-chip models. As such, this review aims to highlight recent advancements in microfluidics-based technologies for the assessment of castration-resistant prostate cancer and its potential to advance current understanding and to improve therapeutic outcomes.
has PII: cells13070575
doi: 10.3390/cells13070575
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Sassi A
      type: Person
      first name: Amel
      last name: Sassi
      member of: Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
  slot:
    index: 2
    item: You L
      type: Person
      first name: Lidan
      last name: You
      member of: Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.Department of Mechanical and Materials Engineering, Queen's University, Kingston, ON K7L 2V9, Canada.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D064129Q000188
has subject term: D008297
has subject term: D000818
has subject term: D006801
has subject term: D044085
has subject term: D059016
source: Cells. 2024-03-26;13(7):.
volume: 13

Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster.
pmid: 38607015
abstract: Blood cells in Drosophila serve primarily innate immune responses. Various stressors influence blood cell homeostasis regarding both numbers and the proportion of blood cell types. The principle molecular mechanisms governing hematopoiesis are conserved amongst species and involve major signaling pathways like Notch, Toll, JNK, JAK/Stat or RTK. Albeit signaling pathways generally rely on the activity of protein kinases, their specific contribution to hematopoiesis remains understudied. Here, we assess the role of Serine/Threonine kinases with the potential to phosphorylate the transcription factor Su(H) in crystal cell homeostasis. Su(H) is central to Notch signal transduction, and its inhibition by phosphorylation impedes crystal cell formation. Overall, nearly twenty percent of all Drosophila Serine/Threonine kinases were studied in two assays, global and hemocyte-specific overexpression and downregulation, respectively. Unexpectedly, the majority of kinases influenced crystal cell numbers, albeit only a few were related to hematopoiesis so far. Four kinases appeared essential for crystal cell formation, whereas most kinases restrained crystal cell development. This group comprises all kinase classes, indicative of the complex regulatory network underlying blood cell homeostasis. The rather indiscriminative response we observed opens the possibility that blood cells measure their overall phospho-status as a proxy for stress-signals, and activate an adaptive immune response accordingly.
has PII: cells13070576
doi: 10.3390/cells13070576
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Deichsel S
      type: Person
      first name: Sebastian
      last name: Deichsel
      member of: Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
  slot:
    index: 2
    item: Gahr BM
      type: Person
      first name: Bernd M
      last name: Gahr
      member of: Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
  slot:
    index: 3
    item: Mastel H
      type: Person
      first name: Helena
      last name: Mastel
      member of: Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
  slot:
    index: 4
    item: Preiss A
      type: Person
      first name: Anette
      last name: Preiss
      member of: Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
  slot:
    index: 5
    item: Nagel AC
      type: Person
      first name: Anja C
      last name: Nagel
      member of: Department of Molecular Genetics, Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D017346Q000378
has primary subject term: D029721Q000378
has subject term: D000818
has subject term: D004331Q000378
has subject term: D001773Q000378
has subject term: D006706
has subject term: D012694Q000378
has subject term: D013912Q000378
source: Cells. 2024-03-26;13(7):.
volume: 13

Ductular Reactions in Liver Injury, Regeneration, and Disease Progression-An Overview.
pmid: 38607018
abstract: Ductular reaction (DR) is a complex cellular response that occurs in the liver during chronic injuries. DR mainly consists of hyper-proliferative or reactive cholangiocytes and, to a lesser extent, de-differentiated hepatocytes and liver progenitors presenting a close spatial interaction with periportal mesenchyme and immune cells. The underlying pathology of DRs leads to extensive tissue remodeling in chronic liver diseases. DR initiates as a tissue-regeneration mechanism in the liver; however, its close association with progressive fibrosis and inflammation in many chronic liver diseases makes it a more complicated pathological response than a simple regenerative process. An in-depth understanding of the cellular physiology of DRs and their contribution to tissue repair, inflammation, and progressive fibrosis can help scientists develop cell-type specific targeted therapies to manage liver fibrosis and chronic liver diseases effectively.
has PII: cells13070579
doi: 10.3390/cells13070579
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Mavila N
      type: Person
      first name: Nirmala
      last name: Mavila
      member of: Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.Division of Applied Cell Biology and Physiology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  slot:
    index: 2
    item: Siraganahalli Eshwaraiah M
      type: Person
      first name: Mallikarjuna
      last name: Siraganahalli Eshwaraiah
      member of: Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  slot:
    index: 3
    item: Kennedy J
      type: Person
      first name: Jaquelene
      last name: Kennedy
      member of: Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D008107Q000473
has subject term: D006801
has subject term: D005355
has subject term: D018450
has subject term: D007249
source: Cells. 2024-03-26;13(7):.
volume: 13

An Automated Imaging-Based Screen for Genetic Modulators of ER Organisation in Cultured Human Cells.
pmid: 38607016
abstract: Hereditary spastic paraplegias (HSPs) are a heterogeneous group of mono-genetic inherited neurological disorders, whose primary manifestation is the disruption of the pyramidal system, observed as a progressive impaired gait and leg spasticity in patients. Despite the large list of genes linked to this group, which exceeds 80 loci, the number of cellular functions which the gene products engage is relatively limited, among which endoplasmic reticulum (ER) morphogenesis appears central. Mutations in genes encoding ER-shaping proteins are the most common cause of HSP, highlighting the importance of correct ER organisation for long motor neuron survival. However, a major bottleneck in the study of ER morphology is the current lack of quantitative methods, with most studies to date reporting, instead, on qualitative changes. Here, we describe and apply a quantitative image-based screen to identify genetic modifiers of ER organisation using a mammalian cell culture system. An analysis reveals significant quantitative changes in tubular ER and dense sheet ER organisation caused by the siRNA-mediated knockdown of HSP-causing genes ATL1 and RTN2. This screen constitutes the first attempt to examine ER distribution in cells in an automated and high-content manner and to detect genes which impact ER organisation.
has PII: cells13070577
doi: 10.3390/cells13070577
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Garcia-Pardo ME
      type: Person
      first name: M Elena
      last name: Garcia-Pardo
      member of: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, 4 Dublin, Ireland.
  slot:
    index: 2
    item: Simpson JC
      type: Person
      first name: Jeremy C
      last name: Simpson
      member of: Cell Screening Laboratory, UCD School of Biology and Environmental Science, University College Dublin, 4 Dublin, Ireland.
  slot:
    index: 3
    item: O'Sullivan NC
      type: Person
      first name: Niamh C
      last name: O'Sullivan
      member of: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, 4 Dublin, Ireland.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D015419Q000235
has primary subject term: D009422
has subject term: D000818
has subject term: D006801
has subject term: D008565Q000378
has subject term: D026901Q000235
has subject term: D019204Q000378
has subject term: D008322Q000378
source: Cells. 2024-03-26;13(7):.
volume: 13

Mitochondria and Reactive Oxygen Species: The Therapeutic Balance of Powers for Duchenne Muscular Dystrophy.
pmid: 38607013
abstract: Duchenne muscular dystrophy (DMD) is a genetic progressive muscle-wasting disorder that leads to rapid loss of mobility and premature death. The absence of functional dystrophin in DMD patients reduces sarcolemma stiffness and increases contraction damage, triggering a cascade of events leading to muscle cell degeneration, chronic inflammation, and deposition of fibrotic and adipose tissue. Efforts in the last decade have led to the clinical approval of novel drugs for DMD that aim to restore dystrophin function. However, combination therapies able to restore dystrophin expression and target the myriad of cellular events found impaired in dystrophic muscle are desirable. Muscles are higher energy consumers susceptible to mitochondrial defects. Mitochondria generate a significant source of reactive oxygen species (ROS), and they are, in turn, sensitive to proper redox balance. In both DMD patients and animal models there is compelling evidence that mitochondrial impairments have a key role in the failure of energy homeostasis. Here, we highlighted the main aspects of mitochondrial dysfunction and oxidative stress in DMD and discussed the recent findings linked to mitochondria/ROS-targeted molecules as a therapeutic approach. In this respect, dual targeting of both mitochondria and redox homeostasis emerges as a potential clinical option in DMD.
has PII: cells13070574
doi: 10.3390/cells13070574
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Casati SR
      type: Person
      first name: Silvia Rosanna
      last name: Casati
      member of: Department of Medical Biotechnology and Translational Medicine (BioMeTra), Università degli Studi di Milano, via Fratelli Cervi 93, 20054 Segrate, Italy.
  slot:
    index: 2
    item: Cervia D
      type: Person
      first name: Davide
      last name: Cervia
      member of: Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), Università degli Studi della Tuscia, Largo dell'Università snc, 01100 Viterbo, Italy.
  slot:
    index: 3
    item: Roux-Biejat P
      type: Person
      first name: Paulina
      last name: Roux-Biejat
      member of: Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, via G.B. Grassi 74, 20157 Milano, Italy.
  slot:
    index: 4
    item: Moscheni C
      type: Person
      first name: Claudia
      last name: Moscheni
      member of: Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, via G.B. Grassi 74, 20157 Milano, Italy.
  slot:
    index: 5
    item: Perrotta C
      type: Person
      first name: Cristiana
      last name: Perrotta
      member of: Department of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, via G.B. Grassi 74, 20157 Milano, Italy.
  slot:
    index: 6
    item: De Palma C
      type: Person
      first name: Clara
      last name: De Palma
      member of: Department of Medical Biotechnology and Translational Medicine (BioMeTra), Università degli Studi di Milano, via Fratelli Cervi 93, 20054 Segrate, Italy.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D020388Q000235
has subject term: D000818
has subject term: D006801
has subject term: D016189Q000235
has subject term: D017382Q000378
has subject term: D018482Q000378
has subject term: D008928Q000378
source: Cells. 2024-03-26;13(7):.
volume: 13

NF-κB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury.
pmid: 38607020
abstract: Spinal cord injury (SCI) leads to significant functional impairments below the level of the injury, and astrocytes play a crucial role in the pathophysiology of SCI. Astrocytes undergo changes and form a glial scar after SCI, which has traditionally been viewed as a barrier to axonal regeneration and functional recovery. Astrocytes activate intracellular signaling pathways, including nuclear factor κB (NF-κB) and Janus kinase-signal transducers and activators of transcription (JAK/STAT), in response to external stimuli. NF-κB and STAT3 are transcription factors that play a pivotal role in initiating gene expression related to astrogliosis. The JAK/STAT signaling pathway is essential for managing secondary damage and facilitating recovery processes post-SCI: inflammation, glial scar formation, and astrocyte survival. NF-κB activation in astrocytes leads to the production of pro-inflammatory factors by astrocytes. NF-κB and STAT3 signaling pathways are interconnected: NF-κB activation in astrocytes leads to the release of interleukin-6 (IL-6), which interacts with the IL-6 receptor and initiates STAT3 activation. By modulating astrocyte responses, these pathways offer promising avenues for enhancing recovery outcomes, illustrating the crucial need for further investigation into their mechanisms and therapeutic applications in SCI treatment.
has PII: cells13070581
doi: 10.3390/cells13070581
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ageeva T
      type: Person
      first name: Tatyana
      last name: Ageeva
      member of: OpenLab Gene and Cell Technology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
  slot:
    index: 2
    item: Rizvanov A
      type: Person
      first name: Albert
      last name: Rizvanov
      member of: OpenLab Gene and Cell Technology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.Division of Medical and Biological Sciences, Tatarstan Academy of Sciences, 420111 Kazan, Russia.
  slot:
    index: 3
    item: Mukhamedshina Y
      type: Person
      first name: Yana
      last name: Mukhamedshina
      member of: OpenLab Gene and Cell Technology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.Department of Histology, Cytology and Embryology, Kazan State Medical University, 420012 Kazan, Russia.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D016328Q000378
has primary subject term: D013119Q000628
has subject term: D006801
has subject term: D001253Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000090862
has subject term: D053612Q000378
has subject term: D005911Q000150
has subject term: D015398Q000502
source: Cells. 2024-03-26;13(7):.
volume: 13

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells.
pmid: 38607019
abstract: Previous research indicates that carcinogenesis involves disrupting the functions of numerous genes, including factors involved in the regulation of transcription and cell proliferation. For these reasons, in endometrial carcinogenesis, we decided to investigate the expression of TSG101 (a suppressor of tumor transformation) and LSF (a transcription factor involved in numerous cellular processes, such as cell cycle regulation, cell growth, development, and apoptosis). LSF may be involved in the regulation of TSG101 expression. The research material consisted of endometrial cancer samples from 60 patients. The control group consisted of normal endometrium samples donated by 60 women undergoing surgery for benign diseases of the female reproductive organs. The samples were subjected to immunohistochemical staining with antibodies specific to TSG101 and LSF. Specific antibodies were used to identify TSG101 and LSF in the examined histopathological preparations. An approximately 14-fold lower risk of endometrial cancer development was observed in patients with TSG expression in more than 75% of the assessed cells (4% vs. 36%; OR = 0.07; p = 0.0182). There was a four-fold lower risk of endometrial cancer development in patients with LSF expression in more than 50% of the assessed cells (32% vs. 64%; OR = 0.26; p = 0.0262). A more than three-fold lower risk of endometrial cancer development was observed in patients with LSF expression in more than 75% of the assessed cells (24% vs. 52%; OR = 0.29; p = 0.0454). Endometrial cancer was diagnosed in those with a lower level of TSG101 expression than in those with a cancer-free endometrium. Decreased expression of TSG101 may be a marker of endometrial cancer, and increased expression of LSF when diagnosed with endometrial cancer may indicate greater advancement of the disease. These markers might be used as diagnostic and prognostic markers-however, there is a lack of a correlation between them.
has PII: cells13070580
doi: 10.3390/cells13070580
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Ziemiński R
      type: Person
      first name: Rafał
      last name: Ziemiński
      member of: Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 2
    item: Stupak A
      type: Person
      first name: Aleksandra
      last name: Stupak
      member of: Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 3
    item: Kwiatek M
      type: Person
      first name: Maciej
      last name: Kwiatek
      member of: Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 4
    item: Gęca T
      type: Person
      first name: Tomasz
      last name: Gęca
      member of: Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 5
    item: Warowicka A
      type: Person
      first name: Alicja
      last name: Warowicka
      member of: Department of Molecular Virology, Institute of Experimental Biology, Adam Mickiewicz University in Poznan, 61-712 Poznań, Poland.
  slot:
    index: 6
    item: Hejne K
      type: Person
      first name: Karolina
      last name: Hejne
      member of: Department of Pathomorphology and Forensic Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 11-082 Olsztyn, Poland.
  slot:
    index: 7
    item: Kwaśniewska A
      type: Person
      first name: Anna
      last name: Kwaśniewska
      member of: Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-059 Lublin, Poland.
  slot:
    index: 8
    item: Goździcka-Józefiak A
      type: Person
      first name: Anna
      last name: Goździcka-Józefiak
      member of: Department of Molecular Virology, Institute of Experimental Biology, Adam Mickiewicz University in Poznan, 61-712 Poznań, Poland.
  slot:
    index: 9
    item: Kwaśniewski W
      type: Person
      first name: Wojciech
      last name: Kwaśniewski
      member of: Department of Gynecology Oncology and Gynecology, Medical University of Lublin, 20-059 Lublin, Poland.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D014157Q000378
has primary subject term: D016889Q000235
has subject term: D005260
has subject term: D006801
has subject term: D002471Q000235
has subject term: D015972
has subject term: D004717Q000378
source: Cells. 2024-03-26;13(7):.
volume: 13

Controlling Recombination to Evolve Bacteriophages.
pmid: 38607024
abstract: Recombination among different phages sometimes facilitates their ability to grow on new hosts. Protocols to direct the evolution of phage host range, as might be used in the application of phage therapy, would then benefit from including steps to enable recombination. Applying mathematical and computational models, in addition to experiments using phages T3 and T7, we consider ways that a protocol may influence recombination levels. We first address coinfection, which is the first step to enabling recombination. The multiplicity of infection (MOI, the ratio of phage to cell concentration) is insufficient for predicting (co)infection levels. The force of infection (the rate at which cells are infected) is also critical but is more challenging to measure. Using both a high force of infection and high MOI (>1) for the different phages ensures high levels of coinfection. We also apply a four-genetic-locus model to study protocol effects on recombinant levels. Recombinants accumulate over multiple generations of phage growth, less so if one phage outgrows the other. Supplementing the phage pool with the low-fitness phage recovers some of this 'lost' recombination. Overall, fine tuning of phage recombination rates will not be practical with wild phages, but qualitative enhancement can be attained with some basic procedures.
has PII: cells13070585
doi: 10.3390/cells13070585
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Bull JJ
      type: Person
      first name: James J
      last name: Bull
      member of: Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID 83844, USA.
  slot:
    index: 2
    item: Wichman HA
      type: Person
      first name: Holly A
      last name: Wichman
      member of: Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID 83844, USA.
  slot:
    index: 3
    item: Krone SM
      type: Person
      first name: Stephen M
      last name: Krone
      member of: Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID 83844, USA.Department of Mathematics and Statistical Science, University of Idaho, Moscow, ID 83844, USA.
  slot:
    index: 4
    item: Molineux IJ
      type: Person
      first name: Ian J
      last name: Molineux
      member of: Institute for Cell and Molecular Biology, Department of Molecular Biosciences, LaMontagne Center for Infectious Diseases, The University of Texas, Austin, TX 78712, USA.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D001435Q000235
has primary subject term: D060085
has subject term: D006801
has subject term: D011995Q000235
source: Cells. 2024-03-28;13(7):.
volume: 13

Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes.
pmid: 38607027
abstract: The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases. Previously, we performed a systemic inhibition of FURIN in a mouse model of atherosclerosis and demonstrated significant plaque reduction and alterations in macrophage function. To understand the cellular mechanisms affected by FURIN inhibition in myeloid cells, we optimized a CRISPR-mediated gene deletion protocol for successfully deriving hemizygous (HZ) and nullizygous (NZ) FURIN knockout clones in U937 monocytic cells using lipotransfection-based procedures and a dual guide RNA delivery strategy. We observed differences in monocyte and macrophage functions involving phagocytosis, lipid accumulation, cell migration, inflammatory gene expression, cytokine release patterns, secreted proteomics (cytokines) and whole-genome transcriptomics between wild-type, HZ and NZ FURIN clones. These studies provide a mechanistic basis on the possible roles of myeloid cell FURIN in cardiovascular disorders.
has PII: cells13070588
doi: 10.3390/cells13070588
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Chua R
      type: Person
      first name: Ruiming
      last name: Chua
      member of: Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.
  slot:
    index: 2
    item: Wang L
      type: Person
      first name: Lijin
      last name: Wang
      member of: Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
  slot:
    index: 3
    item: Singaraja R
      type: Person
      first name: Roshni
      last name: Singaraja
      member of: Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
  slot:
    index: 4
    item: Ghosh S
      type: Person
      first name: Sujoy
      last name: Ghosh
      member of: Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.Laboratory of Computational Biology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D045683Q000235Q000378
has primary subject term: D009000Q000378
has primary subject term: http://id.nlm.nih.gov/mesh/D000072669
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D064112
has subject term: D016207Q000235
has subject term: http://id.nlm.nih.gov/mesh/D000095028
has subject term: http://id.nlm.nih.gov/mesh/D000094704
has subject term: D020298
source: Cells. 2024-03-28;13(7):.
volume: 13

Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism.
pmid: 38607030
abstract: Cockayne syndrome (CS) is a rare hereditary autosomal recessive disorder primarily caused by mutations in Cockayne syndrome protein A (CSA) or B (CSB). While many of the functions of CSB have been at least partially elucidated, little is known about the actual developmental dysregulation in this devasting disorder. Of particular interest is the regulation of cerebral development as the most debilitating symptoms are of neurological nature. We generated neurospheres and cerebral organoids utilizing Cockayne syndrome B protein (CSB)-deficient induced pluripotent stem cells derived from two patients with distinct severity levels of CS and healthy controls. The transcriptome of both developmental timepoints was explored using RNA-Seq and bioinformatic analysis to identify dysregulated biological processes common to both patients with CS in comparison to the control. CSB-deficient neurospheres displayed upregulation of the VEGFA-VEGFR2 signalling pathway, vesicle-mediated transport and head development. CSB-deficient cerebral organoids exhibited downregulation of brain development, neuron projection development and synaptic signalling. We further identified the upregulation of steroid biosynthesis as common to both timepoints, in particular the upregulation of the cholesterol biosynthesis branch. Our results provide insights into the neurodevelopmental dysregulation in patients with CS and strengthen the theory that CS is not only a neurodegenerative but also a neurodevelopmental disorder.
has PII: cells13070591
doi: 10.3390/cells13070591
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Szepanowski LP
      type: Person
      first name: Leon-Phillip
      last name: Szepanowski
      member of: Institute for Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Moorenstrasse 5, D-40225 Duesseldorf, Germany.IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany.
  slot:
    index: 2
    item: Wruck W
      type: Person
      first name: Wasco
      last name: Wruck
      member of: Institute for Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Moorenstrasse 5, D-40225 Duesseldorf, Germany.
  slot:
    index: 3
    item: Kapr J
      type: Person
      first name: Julia
      last name: Kapr
      member of: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany.
  slot:
    index: 4
    item: Rossi A
      type: Person
      first name: Andrea
      last name: Rossi
      member of: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany.
  slot:
    index: 5
    item: Fritsche E
      type: Person
      first name: Ellen
      last name: Fritsche
      member of: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany.
  slot:
    index: 6
    item: Krutmann J
      type: Person
      first name: Jean
      last name: Krutmann
      member of: IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany.
  slot:
    index: 7
    item: Adjaye J
      type: Person
      first name: James
      last name: Adjaye
      member of: Institute for Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Moorenstrasse 5, D-40225 Duesseldorf, Germany.Zayed Centre for Research into Rare Diseases in Children (ZCR), University College London (UCL)-EGA Institute for Women's Health, 20 Guilford Street, London WC1N 1DZ, UK.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D057026Q000378
has primary subject term: D003057Q000235Q000378
has subject term: D006801
has subject term: D004265Q000235
has subject term: D045643Q000378
has subject term: D000075223Q000235Q000378
has subject term: D001921Q000378
has subject term: D009940Q000378
source: Cells. 2024-03-28;13(7):.
volume: 13

Safety of Anti-Reelin Therapeutic Approaches for Chronic Inflammatory Diseases.
pmid: 38607022
abstract: Reelin, a large extracellular glycoprotein, plays critical roles in neuronal development and synaptic plasticity in the central nervous system (CNS). Recent studies have revealed non-neuronal functions of plasma Reelin in inflammation by promoting endothelial-leukocyte adhesion through its canonical pathway in endothelial cells (via ApoER2 acting on NF-κB), as well as in vascular tone regulation and thrombosis. In this study, we have investigated the safety and efficacy of selectively depleting plasma Reelin as a potential therapeutic strategy for chronic inflammatory diseases. We found that Reelin expression remains stable throughout adulthood and that peripheral anti-Reelin antibody treatment with CR-50 efficiently depletes plasma Reelin without affecting its levels or functionality within the CNS. Notably, this approach preserves essential neuronal functions and synaptic plasticity. Furthermore, in mice induced with experimental autoimmune encephalomyelitis (EAE), selective modulation of endothelial responses by anti-Reelin antibodies reduces pathological leukocyte infiltration without completely abolishing diapedesis. Finally, long-term Reelin depletion under metabolic stress induced by a Western diet did not negatively impact the heart, kidney, or liver, suggesting a favorable safety profile. These findings underscore the promising role of peripheral anti-Reelin therapeutic strategies for autoimmune diseases and conditions where endothelial function is compromised, offering a novel approach that may avoid the immunosuppressive side effects associated with conventional anti-inflammatory therapies.
has PII: cells13070583
doi: 10.3390/cells13070583
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Calvier L
      type: Person
      first name: Laurent
      last name: Calvier
      member of: Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 2
    item: Alexander A
      type: Person
      first name: Anna
      last name: Alexander
      member of: Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 3
    item: Marckx AT
      type: Person
      first name: Austin T
      last name: Marckx
      member of: Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 4
    item: Kounnas MZ
      type: Person
      first name: Maria Z
      last name: Kounnas
      member of: Reelin Therapeutics Inc., La Jolla, CA 92130, USA.
  slot:
    index: 5
    item: Durakoglugil M
      type: Person
      first name: Murat
      last name: Durakoglugil
      member of: Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 6
    item: Herz J
      type: Person
      first name: Joachim
      last name: Herz
      member of: Department of Molecular Genetics, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas, TX 75390, USA.Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-27
dp: 2024 03 27
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D000091042Q000037
has primary subject term: D004681Q000188
has primary subject term: D000893Q000627
has subject term: D000818
has subject term: D051379
has subject term: D015816Q000378
has subject term: D042783Q000378
has subject term: D016326Q000378
has subject term: D009419Q000378
has subject term: D012697Q000378
has subject term: D007249Q000188
source: Cells. 2024-03-27;13(7):.
volume: 13

Breaking Bad Proteins-Discovery Approaches and the Road to Clinic for Degraders.
pmid: 38607017
abstract: Proteolysis-targeting chimeras (PROTACs) describe compounds that bind to and induce degradation of a target by simultaneously binding to a ubiquitin ligase. More generally referred to as bifunctional degraders, PROTACs have led the way in the field of targeted protein degradation (TPD), with several compounds currently undergoing clinical testing. Alongside bifunctional degraders, single-moiety compounds, or molecular glue degraders (MGDs), are increasingly being considered as a viable approach for development of therapeutics, driven by advances in rational discovery approaches. This review focuses on drug discovery with respect to bifunctional and molecular glue degraders within the ubiquitin proteasome system, including analysis of mechanistic concepts and discovery approaches, with an overview of current clinical and pre-clinical degrader status in oncology, neurodegenerative and inflammatory disease.
has PII: cells13070578
doi: 10.3390/cells13070578
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Bouvier C
      type: Person
      first name: Corentin
      last name: Bouvier
      member of: Laboratoire de Chimie de Coordination LCC-UPR 8241-CNRS, 31077 Toulouse, France.
  slot:
    index: 2
    item: Lawrence R
      type: Person
      first name: Rachel
      last name: Lawrence
      member of: Sygnature Discovery, Bio City, Pennyfoot St., Nottingham NG1 1GR, UK.
  slot:
    index: 3
    item: Cavallo F
      type: Person
      first name: Francesca
      last name: Cavallo
      member of: Sygnature Discovery, Bio City, Pennyfoot St., Nottingham NG1 1GR, UK.
  slot:
    index: 4
    item: Xolalpa W
      type: Person
      first name: Wendy
      last name: Xolalpa
      member of: Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62209, Morelos, Mexico.
  slot:
    index: 5
    item: Jordan A
      type: Person
      first name: Allan
      last name: Jordan
      member of: Sygnature Discovery, Bio City, Pennyfoot St., Nottingham NG1 1GR, UK.
  slot:
    index: 6
    item: Hjerpe R
      type: Person
      first name: Roland
      last name: Hjerpe
      member of: Sygnature Discovery, Bio City, Pennyfoot St., Nottingham NG1 1GR, UK.
  slot:
    index: 7
    item: Rodriguez MS
      type: Person
      first name: Manuel S
      last name: Rodriguez
      member of: Laboratoire de Chimie de Coordination LCC-UPR 8241-CNRS, 31077 Toulouse, France.Pharmadev, UMR 152, Université de Toulouse, IRD, UT3, 31400 Toulouse, France.B Molecular, Centre Pierre Potier, Canceropôle, 31106 Toulouse, France.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-26
dp: 2024 03 26
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D055808
has primary subject term: D008495
has subject term: D003593
has subject term: D046988
has subject term: D059748
has subject term: D025801
source: Cells. 2024-03-26;13(7):.
volume: 13

Development of a Mouse Experimental System for the In Vivo Characterization of Bioengineered Adipose-Derived Stromal Cells.
pmid: 38607021
abstract: Human adipose-derived stromal cells (ADSCs) are an important resource for cell-based therapies. However, the dynamics of ADSCs after transplantation and their mechanisms of action in recipients remain unclear. Herein, we generated genetically engineered mouse ADSCs to clarify their biodistribution and post-transplantation status and to analyze their role in recipient mesenchymal tissue modeling. Immortalized ADSCs (iADSCs) retained ADSC characteristics such as stromal marker gene expression and differentiation potential. iADSCs expressing a fluorescent reporter gene were seeded into biocompatible nonwoven fabric sheets and transplanted into the dorsal subcutaneous region of neonatal mice. Transplanted donor ADSCs were distributed as CD90-positive stromal cells on the sheets and survived 1 month after transplantation. Although accumulation of T lymphocytes or macrophages inside the sheet was not observed with or without donor cells, earlier migration and accumulation of recipient blood vascular endothelial cells (ECs) inside the sheet was observed in the presence of donor cells. Thus, our mouse model can help in studying the interplay between donor ADSCs and recipient cells over a 1-month period. This system may be of value for assessing and screening bioengineered ADSCs in vivo for optimal cell-based therapies.
has PII: cells13070582
doi: 10.3390/cells13070582
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ichise T
      type: Person
      first name: Taeko
      last name: Ichise
      member of: Department of Plastic and Reconstructive Surgery, University of the Ryukyus Hospital, 207 Uehara, Nishihara 903-0215, Japan.
  slot:
    index: 2
    item: Ichise H
      type: Person
      first name: Hirotake
      last name: Ichise
      member of: Institute for Animal Research, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara 903-0215, Japan.
  slot:
    index: 3
    item: Shimizu Y
      type: Person
      first name: Yusuke
      last name: Shimizu
      member of: Department of Plastic and Reconstructive Surgery, University of the Ryukyus Hospital, 207 Uehara, Nishihara 903-0215, Japan.Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara 903-0215, Japan.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-27
dp: 2024 03 27
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D000273
has primary subject term: D042783
has subject term: D006801
has subject term: D051379
has subject term: D000818
has subject term: D014018
has subject term: D017667
has subject term: D017154
source: Cells. 2024-03-27;13(7):.
volume: 13

Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
pmid: 38607029
abstract: The oral mucosa represents a defensive barrier between the external environment and the rest of the body. Oral mucosal cells are constantly bathed in hypotonic saliva (normally one-third tonicity compared to plasma) and are repeatedly exposed to environmental stresses of tonicity, temperature, and pH by the drinks we imbibe (e.g., hypotonic: water, tea, and coffee; hypertonic: assorted fruit juices, and red wines). In the mouth, the broad-spectrum antiviral mediator MxA (a dynamin-family large GTPase) is constitutively expressed in healthy periodontal tissues and induced by Type III interferons (e.g., IFN-λ1/IL-29). Endogenously induced human MxA and exogenously expressed human GFP-MxA formed membraneless biomolecular condensates in the cytoplasm of oral carcinoma cells (OECM1 cell line). These condensates likely represent storage granules in equilibrium with antivirally active dispersed MxA. Remarkably, cytoplasmic MxA condensates were exquisitely sensitive sensors of hypotonicity-the condensates in oral epithelium disassembled within 1-2 min of exposure of cells to saliva-like one-third hypotonicity, and spontaneously reassembled in the next 4-7 min. Water, tea, and coffee enhanced this disassembly. Fluorescence changes in OECM1 cells preloaded with calcein-AM (a reporter of cytosolic macromolecular crowding ) confirmed that this process involved macromolecular uncrowding and subsequent recrowding secondary to changes in cell volume. However, hypertonicity had little effect on MxA condensates. The spontaneous reassembly of GFP-MxA condensates in oral epithelial cells, even under continuous saliva-like hypotonicity, was slowed by the protein-phosphatase-inhibitor cyclosporin A (CsA) and by the K-channel-blocker tetraethylammonium chloride (TEA); this is suggestive of the involvement of the volume-sensitive WNK kinase-protein phosphatase (PTP)-K-Cl cotransporter (KCC) pathway in the regulated volume decrease (RVD) during condensate reassembly in oral cells. The pres[cell cut: 2464 characters, first 2000 kept]
has PII: cells13070590
doi: 10.3390/cells13070590
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Sehgal PB
      type: Person
      first name: Pravin B
      last name: Sehgal
      member of: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA.Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.
  slot:
    index: 2
    item: Yuan H
      type: Person
      first name: Huijuan
      last name: Yuan
      member of: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA.
  slot:
    index: 3
    item: Centone A
      type: Person
      first name: Anthony
      last name: Centone
      member of: Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
  slot:
    index: 4
    item: DiSenso-Browne SV
      type: Person
      first name: Susan V
      last name: DiSenso-Browne
      member of: Touro College of Dental Medicine at New York Medical College, Hawthorne, NY 10532, USA.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D012463Q000378
has primary subject term: D064547Q000378
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000091582
has subject term: D003069
has subject term: D004847
has subject term: D013662
has subject term: D014867
source: Cells. 2024-03-28;13(7):.
volume: 13

Stem Cells Collection and Mobilization in Adult Autologous/Allogeneic Transplantation: Critical Points and Future Challenges.
pmid: 38607025
abstract: Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and collection facility within a transplant program encompass augmenting mobilization efficiency to optimize the harvest of target cell populations, implementing robust monitoring and predictive strategies for mobilization, streamlining the apheresis procedure to minimize collection duration while ensuring adequate yield, prioritizing patient comfort by reducing the overall collection time, guaranteeing the quality and purity of stem cell products to optimize graft function and transplant success, and facilitating seamless coordination between diverse entities involved in the HSCT process. In this review, we aim to address key questions and provide insights into the critical aspects of mobilizing and collecting hematopoietic stem cells for transplantation purposes.
has PII: cells13070586
doi: 10.3390/cells13070586
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Prisciandaro M
      type: Person
      first name: Michele
      last name: Prisciandaro
      member of: Operative Research Unit of Transfusion Medicine and Cellular Therapy, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 2
    item: Santinelli E
      type: Person
      first name: Enrico
      last name: Santinelli
      member of: Operative Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.Program in Immunology, Molecular Medicine and Applied Biotechnologies, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
  slot:
    index: 3
    item: Tomarchio V
      type: Person
      first name: Valeria
      last name: Tomarchio
      member of: Operative Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 4
    item: Tafuri MA
      type: Person
      first name: Maria Antonietta
      last name: Tafuri
      member of: Operative Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 5
    item: Bonchi C
      type: Person
      first name: Cecilia
      last name: Bonchi
      member of: Operative Research Unit of Transfusion Medicine and Cellular Therapy, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 6
    item: Palazzo G
      type: Person
      first name: Gloria
      last name: Palazzo
      member of: Operative Research Unit of Transfusion Medicine and Cellular Therapy, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 7
    item: Nobile C
      type: Person
      first name: Carolina
      last name: Nobile
      member of: Operative Research Unit of Transfusion Medicine and Cellular Therapy, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 8
    item: Marinucci A
      type: Person
      first name: Alessandra
      last name: Marinucci
      member of: Operative Research Unit of Transfusion Medicine and Cellular Therapy, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 9
    item: Mele M
      type: Person
      first name: Marcella
      last name: Mele
      member of: Operative Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 10
    item: Annibali O
      type: Person
      first name: Ombretta
      last name: Annibali
      member of: Operative Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 11
    item: Rigacci L
      type: Person
      first name: Luigi
      last name: Rigacci
      member of: Operative Research Unit of Hematology and Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
  slot:
    index: 12
    item: Vacca M
      type: Person
      first name: Michele
      last name: Vacca
      member of: Operative Research Unit of Transfusion Medicine and Cellular Therapy, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Roma, Italy.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D018380
has primary subject term: D001781Q000379
has subject term: D000328
has subject term: D006801
has subject term: D019650Q000379
has subject term: D014184
has subject term: D006412
source: Cells. 2024-03-28;13(7):.
volume: 13

Cellular Immunity of Drosophila willistoni Reveals Novel Complexity in Insect Anti-Parasitoid Defense.
pmid: 38607032
abstract: Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes of Drosophila willistoni, a species that has evolved a cellular immune system with extensive variation and a high degree of plasticity. Monoclonal antibodies were raised and used in indirect immunofluorescence experiments to characterize hemocyte subpopulations, follow their functional features and differentiation. Pagocytosis and parasitization assays were used to determine the functional characteristics of hemocyte types. Samples were visualized using confocal and epifluorescence microscopy. We identified a new multinucleated giant hemocyte (MGH) type, which differentiates in the course of the cellular immune response to parasitoids. These cells differentiate in the circulation through nuclear division and cell fusion, and can also be derived from the central hematopoietic organ, the lymph gland. They have a binary function as they take up bacteria by phagocytosis and are involved in the encapsulation and elimination of the parasitoid. Here, we show that, in response to large foreign particles, such as parasitoids, MGHs differentiate, have a binary function and contribute to a highly effective cellular immune response, similar to the foreign body giant cells of vertebrates.
has PII: cells13070593
doi: 10.3390/cells13070593
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Cinege G
      type: Person
      first name: Gyöngyi
      last name: Cinege
      member of: Innate Immunity Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
  slot:
    index: 2
    item: Fodor K
      type: Person
      first name: Kinga
      last name: Fodor
      member of: Innate Immunity Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
  slot:
    index: 3
    item: Magyar LB
      type: Person
      first name: Lilla B
      last name: Magyar
      member of: Innate Immunity Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.Doctoral School of Biology, University of Szeged, 6720 Szeged, Hungary.
  slot:
    index: 4
    item: Lipinszki Z
      type: Person
      first name: Zoltán
      last name: Lipinszki
      member of: MTA SZBK Lendület Laboratory of Cell Cycle Regulation, Institute of Biochemistry, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
  slot:
    index: 5
    item: Hultmark D
      type: Person
      first name: Dan
      last name: Hultmark
      member of: Department of Molecular Biology, Umea University, 901 87 Umea, Sweden.
  slot:
    index: 6
    item: Andó I
      type: Person
      first name: István
      last name: Andó
      member of: Innate Immunity Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D004330
has primary subject term: D010271
has subject term: D000818
has subject term: D002454
has subject term: D010587
has subject term: D007111
source: Cells. 2024-03-29;13(7):.
volume: 13

The Role of Cytokines in Cutaneous T Cell Lymphoma: A Focus on the State of the Art and Possible Therapeutic Targets.
pmid: 38607023
abstract: Cutaneous T cell lymphomas (CTCLs), encompassing mycosis fungoides (MF) and Sézary syndrome (SS), present a complex landscape influenced by cytokines and cellular responses. In this work, the intricate relationship between these inflammatory proteins and disease pathogenesis is examined, focusing on what is known at the clinical and therapeutic levels regarding the most well-known inflammatory mediators. An in-depth look is given to their possible alterations caused by novel immunomodulatory drugs and how they may alter disease progression. From this narrative review of the actual scientific landscape, Interferon-gamma (IFN-γ) emerges as a central player, demonstrating a dual role in both promoting and inhibiting cancer immunity, but the work navigates through all the major interleukins known in inflammatory environments. Immunotherapeutic perspectives are elucidated, highlighting the crucial role of the cutaneous microenvironment in shaping dysfunctional cell trafficking, antitumor immunity, and angiogenesis in MF, showcasing advancements in understanding and targeting the immune phenotype in CTCL. In summary, this manuscript aims to comprehensively explore the multifaceted aspects of CTCL, from the immunopathogenesis and cytokine dynamics centred around TNF-α and IFN-γ to evolving therapeutic modalities. Including all the major known and studied cytokines in this analysis broadens our understanding of the intricate interplay influencing CTCL, paving the way for improved management of this complex lymphoma.
has PII: cells13070584
doi: 10.3390/cells13070584
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Guglielmo A
      type: Person
      first name: Alba
      last name: Guglielmo
      member of: Institute of Dermatology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy.Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, 40138 Bologna, Italy.
  slot:
    index: 2
    item: Zengarini C
      type: Person
      first name: Corrado
      last name: Zengarini
      member of: Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, 40138 Bologna, Italy.Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  slot:
    index: 3
    item: Agostinelli C
      type: Person
      first name: Claudio
      last name: Agostinelli
      member of: Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, 40138 Bologna, Italy.Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  slot:
    index: 4
    item: Motta G
      type: Person
      first name: Giovanna
      last name: Motta
      member of: Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, 40138 Bologna, Italy.Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  slot:
    index: 5
    item: Sabattini E
      type: Person
      first name: Elena
      last name: Sabattini
      member of: Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, 40138 Bologna, Italy.Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
  slot:
    index: 6
    item: Pileri A
      type: Person
      first name: Alessandro
      last name: Pileri
      member of: Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, 40138 Bologna, Italy.Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D012878Q000188Q000209
has primary subject term: D016410Q000188Q000473
has primary subject term: D009182Q000473
has primary subject term: D012751Q000628Q000235
has subject term: D006801
has subject term: D016207Q000235
has subject term: D007371
has subject term: D059016
source: Cells. 2024-03-28;13(7):.
volume: 13

An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis.
pmid: 38607026
abstract: The transmembrane glycoprotein OX40 receptor (OX40) and its ligand, OX40L, are instrumental modulators of the adaptive immune response in humans. OX40 functions as a costimulatory molecule that promotes T cell activation, differentiation, and survival through ligation with OX40L. T cells play an integral role in the pathogenesis of several inflammatory skin conditions, including atopic dermatitis (AD). In particular, T helper 2 (TH2) cells strongly contribute to AD pathogenesis via the production of cytokines associated with type 2 inflammation (e.g., IL-4, IL-5, IL-13, and IL-31) that lead to skin barrier dysfunction and pruritus. The OX40-OX40L interaction also promotes the activation and proliferation of other T helper cell populations (e.g., TH1, TH22, and TH17), and AD patients have demonstrated higher levels of OX40 expression on peripheral blood mononuclear cells than healthy controls. As such, the OX40-OX40L pathway is a potential target for AD treatment. Novel therapies targeting the OX40 pathway are currently in development, several of which have demonstrated promising safety and efficacy results in patients with moderate-to-severe AD. Herein, we review the function of OX40 and the OX40-OX40L signaling pathway, their role in AD pathogenesis, and emerging therapies targeting OX40-OX40L that may offer insights into the future of AD management.
has PII: cells13070587
doi: 10.3390/cells13070587
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Sadrolashrafi K
      type: Person
      first name: Kaviyon
      last name: Sadrolashrafi
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 2
    item: Guo L
      type: Person
      first name: Lily
      last name: Guo
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 3
    item: Kikuchi R
      type: Person
      first name: Robin
      last name: Kikuchi
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 4
    item: Hao A
      type: Person
      first name: Audrey
      last name: Hao
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 5
    item: Yamamoto RK
      type: Person
      first name: Rebecca K
      last name: Yamamoto
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 6
    item: Tolson HC
      type: Person
      first name: Hannah C
      last name: Tolson
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 7
    item: Bilimoria SN
      type: Person
      first name: Sara N
      last name: Bilimoria
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 8
    item: Yee DK
      type: Person
      first name: Danielle K
      last name: Yee
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  slot:
    index: 9
    item: Armstrong AW
      type: Person
      first name: April W
      last name: Armstrong
      member of: Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D003876Q000378Q000473
has subject term: D006801
has subject term: D002454
has subject term: D016207Q000378
has subject term: D007249
has subject term: D007963Q000378
source: Cells. 2024-03-28;13(7):.
volume: 13

Change in Osmotic Pressure Influences the Absorption Spectrum of Hemoglobin inside Red Blood Cells.
pmid: 38607028
abstract: Absorption spectra of red blood cell (RBC) suspensions are investigated in an osmolarity range in the medium from 200 mOsm to 900 mOsm. Three spectral parameters are used to characterize the process of swelling or shrinkage of RBC-the absorbance at 700 nm, the Soret peak height relative to the spectrum background, and the Soret peak wavelength. We show that with an increase in the osmolarity, the absorbance at 700 nm increases and the Soret peak relative height decreases. These changes are related to the changes in the RBC volume and the resulting increase in the hemoglobin intracellular concentration and index of refraction. Confocal microscopy and flow cytometry measurements supported these conclusions. The maximum wavelength of the Soret peak increases with increasing osmolarity due to changes in the oxygenation state of hemoglobin. Using these spectrum parameters, the process of osmosis in RBCs can be followed in real time, but it can also be applied to various processes, leading to changes in the volume and shape of RBCs. Therefore, we conclude that UV-Vis absorption spectrophotometry offers a convenient, easily accessible, and cost-effective method to monitor changes in RBC, which can find applications in the field of drug discovery and diagnostics of RBC and hemoglobin disorders.
has PII: cells13070589
doi: 10.3390/cells13070589
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Karabaliev M
      type: Person
      first name: Miroslav
      last name: Karabaliev
      member of: Department of Physics and Biophysics, Faculty of Medicine, Trakia University, 11 Armeiska, 6000 Stara Zagora, Bulgaria.
  slot:
    index: 2
    item: Tacheva B
      type: Person
      first name: Bilyana
      last name: Tacheva
      member of: Department of Physics and Biophysics, Faculty of Medicine, Trakia University, 11 Armeiska, 6000 Stara Zagora, Bulgaria.
  slot:
    index: 3
    item: Paarvanova B
      type: Person
      first name: Boyana
      last name: Paarvanova
      member of: Department of Physics and Biophysics, Faculty of Medicine, Trakia University, 11 Armeiska, 6000 Stara Zagora, Bulgaria.
  slot:
    index: 4
    item: Georgieva R
      type: Person
      first name: Radostina
      last name: Georgieva
      member of: Department of Physics and Biophysics, Faculty of Medicine, Trakia University, 11 Armeiska, 6000 Stara Zagora, Bulgaria.Institute of Transfusion Medicine, Charite-Universitatsrnedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-28
dp: 2024 03 28
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D004912
has primary subject term: D006454
has subject term: D009997
has subject term: D013053
has subject term: D009994
source: Cells. 2024-03-28;13(7):.
volume: 13

Consequences of Exposure to Hypobaric Hypoxia Associated with High Altitude on Spermatogenesis and Seminal Parameters: A Literature Review.
pmid: 38607031
abstract: Preclinical research has provided compelling evidence indicating that exposure to hypobaric hypoxia (HH) results in a deterioration of spermatogenesis. This adverse effect extends to the underlying molecular mechanisms, progressively leading to impairments in the seminiferous epithelium and germ cells and alterations in semen parameters. Indeed, several studies have demonstrated that animals exposed to HH, whether in natural high-altitude environments or under simulated hypoxic conditions, exhibit damage to the self-renewal and differentiation of spermatogenesis, an increase in germline cell apoptosis, and structural alterations in the seminiferous tubules. One of the primary mechanisms associated with the inhibition of differentiation and an increase in apoptosis among germ cells is an elevated level of oxidative stress, which has been closely associated with HH exposure. Human studies have shown that individuals exposed to HH, such as mountaineers and alpinists, exhibit decreased sperm count, reduced motility, diminished viability, and increased sperm with abnormal morphology in their semen. This evidence strongly suggests that exposure to HH may be considered a significant risk factor that could elevate the prevalence of male infertility. This literature review aims to provide a comprehensive description and propose potential mechanisms that could elucidate the infertility processes induced by HH. By doing so, it contributes to expanding our understanding of the challenges posed by extreme environments on human physiology, opening new avenues for research in this field.
has PII: cells13070592
doi: 10.3390/cells13070592
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Cornejo-Guerra C
      type: Person
      first name: Carlos
      last name: Cornejo-Guerra
      member of: Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomédico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1271155, Chile.
  slot:
    index: 2
    item: Salazar-Ardiles C
      type: Person
      first name: Camila
      last name: Salazar-Ardiles
      member of: Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomédico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1271155, Chile.
  slot:
    index: 3
    item: Morales P
      type: Person
      first name: Patricio
      last name: Morales
      member of: Laboratorio de Biología de la Reproducción, Departamento Biomédico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1271155, Chile.
  slot:
    index: 4
    item: Andrade DC
      type: Person
      first name: David C
      last name: Andrade
      member of: Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomédico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta 1271155, Chile.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D000531
has primary subject term: D012661
has subject term: D000818
has subject term: D008297
has subject term: D006801
has subject term: D005260
has subject term: D000860
has subject term: D013091
has subject term: D013094
source: Cells. 2024-03-29;13(7):.
volume: 13

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.
pmid: 38607033
abstract: Research into the neonatal Fc receptor (FcRn) has increased dramatically ever since Simister and Mostov first purified a rat version of the receptor. Over the years, FcRn has been shown to function not only as a receptor that transfers immunity from mother to fetus but also performs an array of different functions that include transport and recycling of immunoglobulins and albumin in the adult. Due to its important cellular roles, several clinical trials have been designed to either inhibit/enhance FcRn function or develop of non-invasive therapeutic delivery system such as fusion of drugs to IgG Fc or albumin to enhance delivery inside the cells. Here, we report the accidental identification of several FcRn alternatively spliced variants in both mouse and human cells. The four new mouse splice variants are capable of binding immunoglobulins' Fc and Fab portions. In addition, we have identified FcRn-specific vesicles in which immunoglobulins and albumin can be stored and that are involved in the endosomal-lysosomal system. The complexity of FcRn functions offers significant potential to design and develop novel and targeted therapeutics.
has PII: cells13070594
doi: 10.3390/cells13070594
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Haddad G
      type: Person
      first name: George
      last name: Haddad
      member of: Division of Renal Disease and Hypertension, Department of Medicine, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
  slot:
    index: 2
    item: Blaine J
      type: Person
      first name: Judith
      last name: Blaine
      member of: Division of Renal Disease and Hypertension, Department of Medicine, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D011961Q000235Q000378
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D051381
has subject term: D000418Q000378
has subject term: D011992Q000378
has subject term: D007074Q000378
has subject term: D020033
source: Cells. 2024-03-29;13(7):.
volume: 13

Sustained Retinal Defocus Increases the Effect of Induced Myopia on the Retinal Astrocyte Template.
pmid: 38607034
abstract: The aim of this article is to describe sustained myopic eye growth's effect on astrocyte cellular distribution and its association with inner retinal layer thicknesses. Astrocyte density and distribution, retinal nerve fiber layer (RNFL), ganglion cell layer, and inner plexiform layer (IPL) thicknesses were assessed using immunochemistry and spectral-domain optical coherence tomography on seventeen common marmoset retinas (Callithrix jacchus): six induced with myopia from 2 to 6 months of age (6-month-old myopes), three induced with myopia from 2 to 12 months of age (12-month-old myopes), five age-matched 6-month-old controls, and three age-matched 12-month-old controls. Untreated marmoset eyes grew normally, and both RNFL and IPL thicknesses did not change with age, with astrocyte numbers correlating to RNFL and IPL thicknesses in both control age groups. Myopic marmosets did not follow this trend and, instead, exhibited decreased astrocyte density, increased GFAP+ spatial coverage, and thinner RNFL and IPL, all of which worsened over time. Myopic changes in astrocyte density, GFAP+ spatial coverage and inner retinal layer thicknesses suggest astrocyte template reorganization during myopia development and progression which increased over time. Whether or not these changes are constructive or destructive to the retina still remains to be assessed.
has PII: cells13070595
doi: 10.3390/cells13070595
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Lin CR
      type: Person
      first name: Carol R
      last name: Lin
      member of: Department of Biological Sciences, State University of New York College of Optometry, New York, NY 10036, USA.
  slot:
    index: 2
    item: Toychiev A
      type: Person
      first name: Abduqodir
      last name: Toychiev
      member of: Department of Biological Sciences, State University of New York College of Optometry, New York, NY 10036, USA.
  slot:
    index: 3
    item: Ablordeppey RK
      type: Person
      first name: Reynolds K
      last name: Ablordeppey
      member of: Department of Biological Sciences, State University of New York College of Optometry, New York, NY 10036, USA.
  slot:
    index: 4
    item: Srinivas M
      type: Person
      first name: Miduturu
      last name: Srinivas
      member of: Department of Biological Sciences, State University of New York College of Optometry, New York, NY 10036, USA.
  slot:
    index: 5
    item: Benavente-Perez A
      type: Person
      first name: Alexandra
      last name: Benavente-Perez
      member of: Department of Biological Sciences, State University of New York College of Optometry, New York, NY 10036, USA.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D012165
has primary subject term: D009216
has subject term: D000818
has subject term: D001253
has subject term: D009412
has subject term: D012160
has subject term: D041623Q000379
has subject term: D002144
source: Cells. 2024-03-29;13(7):.
volume: 13

Challenges and Considerations of Preclinical Development for iPSC-Based Myogenic Cell Therapy.
pmid: 38607035
abstract: Cell therapies derived from induced pluripotent stem cells (iPSCs) offer a promising avenue in the field of regenerative medicine due to iPSCs' expandability, immune compatibility, and pluripotent potential. An increasing number of preclinical and clinical trials have been carried out, exploring the application of iPSC-based therapies for challenging diseases, such as muscular dystrophies. The unique syncytial nature of skeletal muscle allows stem/progenitor cells to integrate, forming new myonuclei and restoring the expression of genes affected by myopathies. This characteristic makes genome-editing techniques especially attractive in these therapies. With genetic modification and iPSC lineage specification methodologies, immune-compatible healthy iPSC-derived muscle cells can be manufactured to reverse the progression of muscle diseases or facilitate tissue regeneration. Despite this exciting advancement, much of the development of iPSC-based therapies for muscle diseases and tissue regeneration is limited to academic settings, with no successful clinical translation reported. The unknown differentiation process in vivo, potential tumorigenicity, and epigenetic abnormality of transplanted cells are preventing their clinical application. In this review, we give an overview on preclinical development of iPSC-derived myogenic cell transplantation therapies including processes related to iPSC-derived myogenic cells such as differentiation, scaling-up, delivery, and cGMP compliance. And we discuss the potential challenges of each step of clinical translation. Additionally, preclinical model systems for testing myogenic cells intended for clinical applications are described.
has PII: cells13070596
doi: 10.3390/cells13070596
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Sun C
      type: Person
      first name: Congshan
      last name: Sun
      member of: Vita Therapeutics, Baltimore, MD 21043, USA.
  slot:
    index: 2
    item: Serra C
      type: Person
      first name: Carlo
      last name: Serra
      member of: Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
  slot:
    index: 3
    item: Kalicharan BH
      type: Person
      first name: Brianna Harley
      last name: Kalicharan
      member of: Vita Therapeutics, Baltimore, MD 21043, USA.
  slot:
    index: 4
    item: Harding J
      type: Person
      first name: Jeffrey
      last name: Harding
      member of: Vita Therapeutics, Baltimore, MD 21043, USA.
  slot:
    index: 5
    item: Rao M
      type: Person
      first name: Mahendra
      last name: Rao
      member of: Vita Therapeutics, Baltimore, MD 21043, USA.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D057026Q000378
has primary subject term: D009136Q000378
has subject term: D006801
has subject term: D018482Q000502
has subject term: D064987
has subject term: D002454
source: Cells. 2024-03-29;13(7):.
volume: 13

CD99 Expression and Prognostic Impact in Glioblastoma: A Single-Center Cohort Study.
pmid: 38607036
abstract: Glioblastoma is the most frequent and aggressive brain tumor in adults. This study aims to evaluate the expression and prognostic impact of CD99, a membrane glycoprotein involved in cellular migration and invasion. In a cohort of patients with glioblastoma treated with surgery, radiotherapy and temozolomide, we retrospectively analyzed tumor expression of CD99 by immunohistochemistry (IHC) and by quantitative real-time polymerase chain reaction (qRT-PCR) for both the wild type (CD99wt) and the truncated (CD99sh) isoforms. The impact on overall survival (OS) was assessed with the Kaplan-Meier method and log-rank test and by multivariable Cox regression. Forty-six patients with glioblastoma entered this study. Immunohistochemical expression of CD99 was present in 83%. Only the CD99wt isoform was detected by qRT-PCR and was significantly correlated with CD99 expression evaluated by IHC (rho = 0.309, p = 0.037). CD99 expression was not associated with OS, regardless of the assessment methodology used (p = 0.61 for qRT-PCR and p = 0.73 for IHC). In an exploratory analysis of The Cancer Genome Atlas, casuistry of glioblastomas CD99 expression was not associated with OS nor with progression-free survival. This study confirms a high expression of CD99 in glioblastoma but does not show any significant impact on survival. Further preclinical studies are needed to define its role as a therapeutic target in glioblastoma.
has PII: cells13070597
doi: 10.3390/cells13070597
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Rocca A
      type: Person
      first name: Andrea
      last name: Rocca
      member of: Department of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
  slot:
    index: 2
    item: Giudici F
      type: Person
      first name: Fabiola
      last name: Giudici
      member of: Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.
  slot:
    index: 3
    item: Donofrio CA
      type: Person
      first name: Carmine Antonio
      last name: Donofrio
      member of: Neurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
  slot:
    index: 4
    item: Bottin C
      type: Person
      first name: Cristina
      last name: Bottin
      member of: Department of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
  slot:
    index: 5
    item: Pinamonti M
      type: Person
      first name: Maurizio
      last name: Pinamonti
      member of: Department of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
  slot:
    index: 6
    item: Ferrari B
      type: Person
      first name: Benvenuto
      last name: Ferrari
      member of: Breast and Brain Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 7
    item: Schettini F
      type: Person
      first name: Francesco
      last name: Schettini
      member of: Translational Genomics and Targeted Therapies in Solid Tumors Group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), C. Villaroel 170, 08036 Barcelona, Spain.Medical Oncology Department, Hospital Clínic of Barcelona, 08036 Barcelona, Spain.Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08036 Barcelona, Spain.
  slot:
    index: 8
    item: Pineda E
      type: Person
      first name: Estela
      last name: Pineda
      member of: Medical Oncology Department, Hospital Clínic of Barcelona, 08036 Barcelona, Spain.Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, 08036 Barcelona, Spain.
  slot:
    index: 9
    item: Panni S
      type: Person
      first name: Stefano
      last name: Panni
      member of: Breast and Brain Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 10
    item: Cominetti M
      type: Person
      first name: Marika
      last name: Cominetti
      member of: Neurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 11
    item: D'Auria P
      type: Person
      first name: Patrizia
      last name: D'Auria
      member of: Neurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 12
    item: Bianchini S
      type: Person
      first name: Simonetta
      last name: Bianchini
      member of: Neurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 13
    item: Varotti E
      type: Person
      first name: Elena
      last name: Varotti
      member of: Pathology Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 14
    item: Ungari M
      type: Person
      first name: Marco
      last name: Ungari
      member of: Pathology Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 15
    item: Ciccarelli S
      type: Person
      first name: Stefano
      last name: Ciccarelli
      member of: Radiotherapy Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 16
    item: Filippini M
      type: Person
      first name: Marzia
      last name: Filippini
      member of: Radiotherapy Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 17
    item: Brenna S
      type: Person
      first name: Sarah
      last name: Brenna
      member of: Radiotherapy Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 18
    item: Fiori V
      type: Person
      first name: Valentina
      last name: Fiori
      member of: Diatheva srl, 61030 Cartoceto, Italy.
  slot:
    index: 19
    item: Di Mambro T
      type: Person
      first name: Tomas
      last name: Di Mambro
      member of: Diatheva srl, 61030 Cartoceto, Italy.
  slot:
    index: 20
    item: Sparti A
      type: Person
      first name: Angelo
      last name: Sparti
      member of: Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.
  slot:
    index: 21
    item: Magnani M
      type: Person
      first name: Mauro
      last name: Magnani
      member of: Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.
  slot:
    index: 22
    item: Zanconati F
      type: Person
      first name: Fabrizio
      last name: Zanconati
      member of: Department of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.
  slot:
    index: 23
    item: Generali D
      type: Person
      first name: Daniele
      last name: Generali
      member of: Department of Medical, Surgical and Health Sciences, University of Trieste, 34147 Trieste, Italy.Breast and Brain Unit, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
  slot:
    index: 24
    item: Fioravanti A
      type: Person
      first name: Antonio
      last name: Fioravanti
      member of: Neurosurgery, ASST Cremona, Viale Concordia 1, 26100 Cremona, Italy.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D005909Q000188
has subject term: D000328
has subject term: D006801
has subject term: D015331
has subject term: D011379
has subject term: D012189
has subject term: D000077204Q000627
has subject term: http://id.nlm.nih.gov/mesh/D000071443
source: Cells. 2024-03-29;13(7):.
volume: 13

The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor.
pmid: 38607037
abstract: Zika virus (ZIKV) infection and pathogenesis are linked to the disruption of neurogenesis, congenital Zika syndrome and microcephaly by affecting neural progenitor cells. Nonstructural protein 5 (NS5) is the largest product encoded by ZIKV-RNA and is important for replication and immune evasion. Here, we studied the potential effects of NS5 on microtubules (MTs) and autophagy flux, together with the interplay of NS5 with histone deacetylase 6 (HDAC6). Fluorescence microscopy, biochemical cell-fractionation combined with the use of HDAC6 mutants, chemical inhibitors and RNA interference indicated that NS5 accumulates in nuclear structures and strongly promotes the acetylation of MTs that aberrantly reorganize in nested structures. Similarly, NS5 accumulates the p62 protein, an autophagic-flux marker. Therefore, NS5 alters events that are under the control of the autophagic tubulin-deacetylase HDAC6. HDAC6 appears to degrade NS5 by autophagy in a deacetylase- and BUZ domain-dependent manner and to control the cytoplasmic expression of NS5. Moreover, NS5 inhibits RNA-mediated RIG-I interferon (IFN) production, resulting in greater activity when autophagy is inhibited (i.e., effect correlated with NS5 stability). Therefore, it is conceivable that NS5 contributes to cell toxicity and pathogenesis, evading the IFN-immune response by overcoming HDAC6 functions. HDAC6 has emerged as an anti-ZIKV factor by targeting NS5.
has PII: cells13070598
doi: 10.3390/cells13070598
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Pérez-Yanes S
      type: Person
      first name: Silvia
      last name: Pérez-Yanes
      member of: Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain.
  slot:
    index: 2
    item: Lorenzo-Sánchez I
      type: Person
      first name: Iria
      last name: Lorenzo-Sánchez
      member of: Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain.
  slot:
    index: 3
    item: Cabrera-Rodríguez R
      type: Person
      first name: Romina
      last name: Cabrera-Rodríguez
      member of: Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain.
  slot:
    index: 4
    item: García-Luis J
      type: Person
      first name: Jonay
      last name: García-Luis
      member of: Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain.
  slot:
    index: 5
    item: Trujillo-González R
      type: Person
      first name: Rodrigo
      last name: Trujillo-González
      member of: Department of Análisis Matemático, Facultad de Ciencias, Universidad de La Laguna, 38296 La Laguna, Spain.
  slot:
    index: 6
    item: Estévez-Herrera J
      type: Person
      first name: Judith
      last name: Estévez-Herrera
      member of: Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain.
  slot:
    index: 7
    item: Valenzuela-Fernández A
      type: Person
      first name: Agustín
      last name: Valenzuela-Fernández
      member of: Laboratorio de Inmunología Celular y Viral, Unidad de Farmacología, Sección de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 La Laguna, Spain.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D000071244Q000502
has primary subject term: http://id.nlm.nih.gov/mesh/D000071243
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000073864
has subject term: D014404
has subject term: D008870
has subject term: D012313
has subject term: D001343
source: Cells. 2024-03-29;13(7):.
volume: 13

Non-Coding RNAs: Regulators of Stress, Ageing, and Developmental Decisions in Yeast?
pmid: 38607038
abstract: Cells must change their properties in order to adapt to a constantly changing environment. Most of the cellular sensing and regulatory mechanisms described so far are based on proteins that serve as sensors, signal transducers, and effectors of signalling pathways, resulting in altered cell physiology. In recent years, however, remarkable examples of the critical role of non-coding RNAs in some of these regulatory pathways have been described in various organisms. In this review, we focus on all classes of non-coding RNAs that play regulatory roles during stress response, starvation, and ageing in different yeast species as well as in structured yeast populations. Such regulation can occur, for example, by modulating the amount and functional state of tRNAs, rRNAs, or snRNAs that are directly involved in the processes of translation and splicing. In addition, long non-coding RNAs and microRNA-like molecules are bona fide regulators of the expression of their target genes. Non-coding RNAs thus represent an additional level of cellular regulation that is gradually being uncovered.
has PII: cells13070599
doi: 10.3390/cells13070599
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Čáp M
      type: Person
      first name: Michal
      last name: Čáp
      member of: Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 128 00 Prague, Czech Republic.
  slot:
    index: 2
    item: Palková Z
      type: Person
      first name: Zdena
      last name: Palková
      member of: Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 128 00 Prague, Czech Republic.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D035683Q000235
has primary subject term: D062085Q000235
source: Cells. 2024-03-29;13(7):.
volume: 13

Preclinical Development of Antisense Oligonucleotides to Rescue Aberrant Splicing Caused by an Ultrarare ABCA4 Variant in a Child with Early-Onset Stargardt Disease.
pmid: 38607040
abstract: Precision medicine is rapidly gaining recognition in the field of (ultra)rare conditions, where only a few individuals in the world are affected. Clinical trial design for a small number of patients is extremely challenging, and for this reason, the development of N-of-1 strategies is explored to accelerate customized therapy design for rare cases. A strong candidate for this approach is Stargardt disease (STGD1), an autosomal recessive macular degeneration characterized by high genetic and phenotypic heterogeneity. STGD1 is caused by pathogenic variants in ABCA4, and amongst them, several deep-intronic variants alter the pre-mRNA splicing process, generally resulting in the insertion of pseudoexons (PEs) into the final transcript. In this study, we describe a 10-year-old girl harboring the unique deep-intronic ABCA4 variant c.6817-713A>G. Clinically, she presents with typical early-onset STGD1 with a high disease symmetry between her two eyes. Molecularly, we designed antisense oligonucleotides (AONs) to block the produced PE insertion. Splicing rescue was assessed in three different in vitro models: HEK293T cells, fibroblasts, and photoreceptor precursor cells, the last two being derived from the patient. Overall, our research is intended to serve as the basis for a personalized N-of-1 AON-based treatment to stop early vision loss in this patient.
has PII: cells13070601
doi: 10.3390/cells13070601
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Suárez-Herrera N
      type: Person
      first name: Nuria
      last name: Suárez-Herrera
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 2
    item: Li CHZ
      type: Person
      first name: Catherina H Z
      last name: Li
      member of: Department of Ophthalmology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 3
    item: Leijsten N
      type: Person
      first name: Nico
      last name: Leijsten
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 4
    item: Karjosukarso DW
      type: Person
      first name: Dyah W
      last name: Karjosukarso
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 5
    item: Corradi Z
      type: Person
      first name: Zelia
      last name: Corradi
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 6
    item: Bukkems F
      type: Person
      first name: Femke
      last name: Bukkems
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 7
    item: Duijkers L
      type: Person
      first name: Lonneke
      last name: Duijkers
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 8
    item: Cremers FPM
      type: Person
      first name: Frans P M
      last name: Cremers
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 9
    item: Hoyng CB
      type: Person
      first name: Carel B
      last name: Hoyng
      member of: Department of Ophthalmology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.Dutch Center for RNA Therapeutics, 2311 EZ Leiden, The Netherlands.
  slot:
    index: 10
    item: Garanto A
      type: Person
      first name: Alejandro
      last name: Garanto
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.Dutch Center for RNA Therapeutics, 2311 EZ Leiden, The Netherlands.Department of Pediatrics, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  slot:
    index: 11
    item: Collin RWJ
      type: Person
      first name: Rob W J
      last name: Collin
      member of: Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.Dutch Center for RNA Therapeutics, 2311 EZ Leiden, The Netherlands.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D016376Q000494Q000627
has primary subject term: D018528Q000235
has subject term: D006801
has subject term: D005260
has subject term: D002648
has subject term: D000080362Q000235
has subject term: D057809
has subject term: D007438
source: Cells. 2024-03-29;13(7):.
volume: 13

The Identification of a Novel Nucleomodulin MbovP467 of Mycoplasmopsis bovis and Its Potential Contribution in Pathogenesis.
pmid: 38607043
abstract: Mycoplasmopsis bovis is a causative agent of crucial diseases in both dairy and beef cattle leading to substantial economic losses. However, limited control measures for M. bovis-related diseases exist due to a lack of understanding about the virulence factors of this pathogen, a common challenge in mycoplasma research. Consequently, this study aimed to characterize a novel nucleomodulin as a virulence-related factor of M. bovis. Employing bioinformatic tools, we initially predicted MbovP467 to be a secreted protein with a nuclear localization signal based on SignalP scores and the cNLS (Nuclear Localization Signal) Mapper, respectively. Subsequently, the MbovP467 gene was synthesized and cloned into a pEGFP plasmid with EGFP labeling to obtain a recombinant plasmid (rpEGFP-MbovP467) and then was also cloned in pET-30a with a consideration for an Escherichia coli codon bias and expressed and purified for the production of polyclonal antibodies against the recombinant MbovP467 protein. Confocal microscopy and a Western blotting assay confirmed the nuclear location of MbovP467 in bovine macrophages (BoMacs). RNA-seq data revealed 220 up-regulated and 20 down-regulated genes in the rpEGFP-MbovP467-treated BoMac group compared to the control group (pEGFP). A GO- and KEGG-enrichment analysis identified associations with inflammatory responses, G protein-coupled receptor signaling pathways, nuclear receptor activity, sequence-specific DNA binding, the regulation of cell proliferation, IL-8, apoptotic processes, cell growth and death, the TNF signaling pathway, the NF-κB signaling pathway, pathways in cancer, and protein families of signaling and cellular processes among the differentially expressed up-regulated mRNAs. Further experiments, investigating cell viability and the inflammatory response, demonstrated that MbovP467 reduces BoMac cell viability and induces the mRNA expression of IL-1β, IL-6, IL-8, TNF-α, and apoptosis in BoMac cells. Further, MbovP467 increased th[cell cut: 2172 characters, first 2000 kept]
has PII: cells13070604
doi: 10.3390/cells13070604
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Raheem A
      type: Person
      first name: Abdul
      last name: Raheem
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 2
    item: Lu D
      type: Person
      first name: Doukun
      last name: Lu
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 3
    item: Khalid AK
      type: Person
      first name: Abdul Karim
      last name: Khalid
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 4
    item: Zhao G
      type: Person
      first name: Gang
      last name: Zhao
      member of: Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China.
  slot:
    index: 5
    item: Fu Y
      type: Person
      first name: Yingjie
      last name: Fu
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 6
    item: Chen Y
      type: Person
      first name: Yingyu
      last name: Chen
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 7
    item: Chen X
      type: Person
      first name: Xi
      last name: Chen
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 8
    item: Hu C
      type: Person
      first name: Changmin
      last name: Hu
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 9
    item: Chen J
      type: Person
      first name: Jianguo
      last name: Chen
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 10
    item: Chen H
      type: Person
      first name: Huanchun
      last name: Chen
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  slot:
    index: 11
    item: Guo A
      type: Person
      first name: Aizhen
      last name: Guo
      member of: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.Hubei International Scientific and Technological Cooperation Base of Veterinary Epidemiology, Huazhong Agricultural University, Wuhan 430070, China.International Research Center for Animal Disease, Ministry of Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D014409Q000378
has primary subject term: D016209Q000378
has subject term: D000818
has subject term: D002417
has subject term: D019913Q000378
has subject term: D005786
has subject term: D016328Q000378
source: Cells. 2024-03-29;13(7):.
volume: 13

Unraveling Desmin's Head Domain Structure and Function.
pmid: 38607042
abstract: Understanding the structure and function of intermediate filaments (IFs) is necessary in order to explain why more than 70 related IF genes have evolved in vertebrates while maintaining such dramatically tissue-specific expression. Desmin is a member of the large multigene family of IF proteins and is specifically expressed in myocytes. In an effort to elucidate its muscle-specific behavior, we have used a yeast two-hybrid system in order to identify desmin's head binding partners. We described a mitochondrial and a lysosomal protein, NADH ubiquinone oxidoreductase core subunit S2 (NDUFS2), and saposin D, respectively, as direct desmin binding partners. In silico analysis indicated that both interactions at the atomic level occur in a very similar way, by the formation of a three-helix bundle with hydrophobic interactions in the interdomain space and hydrogen bonds at R16 and S32 of the desmin head domain. The interactions, confirmed also by GST pull-down assays, indicating the necessity of the desmin head domain and, furthermore, point out its role in function of mitochondria and lysosomes, organelles which are disrupted in myopathies due to desmin head domain mutations.
has PII: cells13070603
doi: 10.3390/cells13070603
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Vlachakis D
      type: Person
      first name: Dimitrios
      last name: Vlachakis
      member of: Biotechnology Department, Agricultural University of Athens, 11855 Athens, Greece.
  slot:
    index: 2
    item: Tsilafakis K
      type: Person
      first name: Konstantinos
      last name: Tsilafakis
      member of: Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephesiou, 11527 Athens, Greece.Biochemistry & Biotechnology Department, University of Thessaly, 41500 Larisa, Greece.
  slot:
    index: 3
    item: Kostavasili I
      type: Person
      first name: Ioanna
      last name: Kostavasili
      member of: Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephesiou, 11527 Athens, Greece.
  slot:
    index: 4
    item: Kossida S
      type: Person
      first name: Sophia
      last name: Kossida
      member of: IMGT, The International ImMunoGeneTics Information System, National Center for Scientific Research (CNRS), Institute of Human Genetics (IGH), University of Montpellier (UM), 34090 Montpellier, France.
  slot:
    index: 5
    item: Mavroidis M
      type: Person
      first name: Manolis
      last name: Mavroidis
      member of: Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephesiou, 11527 Athens, Greece.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D003893Q000737Q000378
has subject term: D000818
has subject term: D007382Q000378
has subject term: D009132Q000378
has subject term: D009135Q000235Q000378
has subject term: D009154
has subject term: D006801
source: Cells. 2024-03-29;13(7):.
volume: 13

Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies.
pmid: 38607045
abstract: In vitro and preclinical in vivo research in the last 35 years has clearly highlighted the crucial physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and satellite glial cells/Schwann cells in the central and peripheral nervous system, respectively. Several possible pharmacological targets to various neurodegenerative disorders and painful conditions have therefore been successfully identified, including receptors and enzymes, and mediators of neuroinflammation. However, the translation of these promising data to a clinical setting is often hampered by both technical and biological difficulties, making it necessary to perform experiments on human cells and models of the various diseases. In this review we will, therefore, summarize the most relevant data on the contribution of glial cells to human pathologies and on their possible pharmacological modulation based on data obtained in post-mortem tissues and in iPSC-derived human brain cells and organoids. The possibility of an in vivo visualization of glia reaction to neuroinflammation in patients will be also discussed.
has PII: cells13070606
doi: 10.3390/cells13070606
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Magni G
      type: Person
      first name: Giulia
      last name: Magni
      member of: Laboratory of Pain Therapy and Neuroimmunology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, Italy.
  slot:
    index: 2
    item: Riboldi B
      type: Person
      first name: Benedetta
      last name: Riboldi
      member of: Laboratory of Pain Therapy and Neuroimmunology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, Italy.
  slot:
    index: 3
    item: Ceruti S
      type: Person
      first name: Stefania
      last name: Ceruti
      member of: Laboratory of Pain Therapy and Neuroimmunology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, Italy.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-03-30
dp: 2024 03 30
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: http://id.nlm.nih.gov/mesh/D000090862
has primary subject term: D009457
has subject term: D006801
has subject term: D002490
has subject term: D017628Q000502
has subject term: D001253Q000502
source: Cells. 2024-03-30;13(7):.
volume: 13

Extracellular Vesicles of Patients on Peritoneal Dialysis Inhibit the TGF-β- and PDGF-B-Mediated Fibrotic Processes.
pmid: 38607044
abstract: Among patients on peritoneal dialysis (PD), 50-80% will develop peritoneal fibrosis, and 0.5-4.4% will develop life-threatening encapsulating peritoneal sclerosis (EPS). Here, we investigated the role of extracellular vesicles (EVs) on the TGF-β- and PDGF-B-driven processes of peritoneal fibrosis. EVs were isolated from the peritoneal dialysis effluent (PDE) of children receiving continuous ambulatory PD. The impact of PDE-EVs on the epithelial-mesenchymal transition (EMT) and collagen production of the peritoneal mesothelial cells and fibroblasts were investigated in vitro and in vivo in the chlorhexidine digluconate (CG)-induced mice model of peritoneal fibrosis. PDE-EVs showed spherical morphology in the 100 nm size range, and their spectral features, CD63, and annexin positivity were characteristic of EVs. PDE-EVs penetrated into the peritoneal mesothelial cells and fibroblasts and reduced their PDE- or PDGF-B-induced proliferation. Furthermore, PDE-EVs inhibited the PDE- or TGF-β-induced EMT and collagen production of the investigated cell types. PDE-EVs contributed to the mesothelial layer integrity and decreased the submesothelial thickening of CG-treated mice. We demonstrated that PDE-EVs significantly inhibit the PDGF-B- or TGF-β-induced fibrotic processes in vitro and in vivo, suggesting that EVs may contribute to new therapeutic strategies to treat peritoneal fibrosis and other fibroproliferative diseases.
has PII: cells13070605
doi: 10.3390/cells13070605
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Szebeni B
      type: Person
      first name: Beáta
      last name: Szebeni
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.HUN-REN-SU Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary.
  slot:
    index: 2
    item: Veres-Székely A
      type: Person
      first name: Apor
      last name: Veres-Székely
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.HUN-REN-SU Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary.
  slot:
    index: 3
    item: Pap D
      type: Person
      first name: Domonkos
      last name: Pap
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.HUN-REN-SU Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary.
  slot:
    index: 4
    item: Bokrossy P
      type: Person
      first name: Péter
      last name: Bokrossy
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.
  slot:
    index: 5
    item: Varga Z
      type: Person
      first name: Zoltán
      last name: Varga
      member of: TTK Biological Nanochemistry Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
  slot:
    index: 6
    item: Gaál A
      type: Person
      first name: Anikó
      last name: Gaál
      member of: TTK Biological Nanochemistry Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
  slot:
    index: 7
    item: Mihály J
      type: Person
      first name: Judith
      last name: Mihály
      member of: TTK Biological Nanochemistry Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, 1117 Budapest, Hungary.
  slot:
    index: 8
    item: Pállinger É
      type: Person
      first name: Éva
      last name: Pállinger
      member of: Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1089 Budapest, Hungary.
  slot:
    index: 9
    item: Takács IM
      type: Person
      first name: István M
      last name: Takács
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.
  slot:
    index: 10
    item: Pajtók C
      type: Person
      first name: Csenge
      last name: Pajtók
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.
  slot:
    index: 11
    item: Bernáth M
      type: Person
      first name: Mária
      last name: Bernáth
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.
  slot:
    index: 12
    item: Reusz GS
      type: Person
      first name: György S
      last name: Reusz
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.
  slot:
    index: 13
    item: Szabó AJ
      type: Person
      first name: Attila J
      last name: Szabó
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.HUN-REN-SU Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary.
  slot:
    index: 14
    item: Vannay Á
      type: Person
      first name: Ádám
      last name: Vannay
      member of: Pediatric Center, MTA Center of Excellence, Semmelweis University, 1083 Budapest, Hungary.HUN-REN-SU Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D056627Q000378Q000473
has primary subject term: D010530Q000009
has primary subject term: http://id.nlm.nih.gov/mesh/D000067128
has subject term: D002648
has subject term: D006801
has subject term: D051379
has subject term: D000818
has subject term: D016212Q000378
has subject term: D010537
has subject term: D003094Q000378
source: Cells. 2024-03-29;13(7):.
volume: 13

Visualization of the Association of Dimeric Protein Complexes on Specific Enhancers in the Salivary Gland Nuclei of Drosophila Larva.
pmid: 38607052
abstract: Transcription factors (TFs) regulate gene expression by recognizing specific target enhancers in the genome. The DNA-binding and regulatory activity of TFs depend on the presence of additional protein partners, leading to the formation of versatile and dynamic multimeric protein complexes. Visualizing these protein-protein interactions (PPIs) in the nucleus is key for decrypting the molecular cues underlying TF specificity in vivo. Over the last few years, Bimolecular Fluorescence Complementation (BiFC) has been developed in several model systems and applied in the analysis of different types of PPIs. In particular, BiFC has been applied when analyzing PPIs with hundreds of TFs in the nucleus of live Drosophila embryos. However, the visualization of PPIs at the level of specific target enhancers or genomic regions of interest awaits the advent of DNA-labelling methods that can be coupled with BiFC. Here, we present a novel experimental strategy that we have called BiFOR and that is based on the coupling of BiFC with the bacterial ANCHOR DNA-labelling system. We demonstrate that BiFOR enables the precise quantification of the enrichment of specific dimeric protein complexes on target enhancers in Drosophila salivary gland nuclei. Given its versatility and sensitivity, BiFOR could be applied more widely to other tissues during Drosophila development. Our work sets up the experimental basis for future applications of this strategy.
has PII: cells13070613
doi: 10.3390/cells13070613
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Vanderperre S
      type: Person
      first name: Solène
      last name: Vanderperre
      member of: Institut de Génomique Fonctionnelle de Lyon (IGFL), UMR5242, Ecole Normale Supérieure de Lyon (ENSL), CNRS, Université de Lyon, 69007 Lyon, France.
  slot:
    index: 2
    item: Merabet S
      type: Person
      first name: Samir
      last name: Merabet
      member of: Institut de Génomique Fonctionnelle de Lyon (IGFL), UMR5242, Ecole Normale Supérieure de Lyon (ENSL), CNRS, Université de Lyon, 69007 Lyon, France.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-04-01
dp: 2024 04 01
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D004330Q000378
has primary subject term: D029721Q000235Q000378
has subject term: D000818
has subject term: D008856Q000379
has subject term: D014157Q000378
has subject term: D004247Q000378
source: Cells. 2024-04-01;13(7):.
volume: 13

Genetic Signature of Human Pancreatic Cancer and Personalized Targeting.
pmid: 38607041
abstract: Pancreatic cancer is a highly lethal disease with a 5-year survival rate of around 11-12%. Surgery, being the treatment of choice, is only possible in 20% of symptomatic patients. The main reason is that when it becomes symptomatic, IT IS the tumor is usually locally advanced and/or has metastasized to distant organs; thus, early diagnosis is infrequent. The lack of specific early symptoms is an important cause of late diagnosis. Unfortunately, diagnostic tumor markers become positive at a late stage, and there is a lack of early-stage markers. Surgical and non-surgical cases are treated with neoadjuvant and/or adjuvant chemotherapy, and the results are usually poor. However, personalized targeted therapy directed against tumor drivers may improve this situation. Until recently, many pancreatic tumor driver genes/proteins were considered untargetable. Chemical and physical characteristics of mutated KRAS are a formidable challenge to overcome. This situation is slowly changing. For the first time, there are candidate drugs that can target the main driver gene of pancreatic cancer: KRAS. Indeed, KRAS inhibition has been clinically achieved in lung cancer and, at the pre-clinical level, in pancreatic cancer as well. This will probably change the very poor outlook for this disease. This paper reviews the genetic characteristics of sporadic and hereditary predisposition to pancreatic cancer and the possibilities of a personalized treatment according to the genetic signature.
has PII: cells13070602
doi: 10.3390/cells13070602
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Reshkin SJ
      type: Person
      first name: Stephan J
      last name: Reshkin
      member of: Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro , 70125 Bari, Italy.
  slot:
    index: 2
    item: Cardone RA
      type: Person
      first name: Rosa Angela
      last name: Cardone
      member of: Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro , 70125 Bari, Italy.
  slot:
    index: 3
    item: Koltai T
      type: Person
      first name: Tomas
      last name: Koltai
      member of: Oncomed, Via Pier Capponi 6, 50132 Florence, Italy.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D010190Q000188Q000235Q000175
has primary subject term: D008175Q000235
has subject term: D006801
has subject term: D016283Q000235
has subject term: D020360
has subject term: D014408Q000235
source: Cells. 2024-03-29;13(7):.
volume: 13

Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes.
pmid: 38607046
abstract: Membrane nanotubes (NTs) are dynamic communication channels connecting spatially separated cells even over long distances and promoting the transport of different cellular cargos. NTs are also involved in the intercellular spread of different pathogens and the deterioration of some neurological disorders. Transport processes via NTs may be controlled by cytoskeletal elements. NTs are frequently observed membrane projections in numerous mammalian cell lines, including various immune cells, but their functional significance in the 'antibody factory' B cells is poorly elucidated. Here, we report that as active channels, NTs of B-lymphoma cells can mediate bidirectional mitochondrial transport, promoted by the cooperation of two different cytoskeletal motor proteins, kinesin along microtubules and myosin VI along actin, and bidirectional transport processes are also supported by the heterogeneous arrangement of the main cytoskeletal filament systems of the NTs. We revealed that despite NTs and axons being different cell extensions, the mitochondrial transport they mediate may exhibit significant similarities. Furthermore, we found that microtubules may improve the stability and lifespan of B-lymphoma-cell NTs, while F-actin strengthens NTs by providing a structural framework for them. Our results may contribute to a better understanding of the regulation of the major cells of humoral immune response to infections.
has PII: cells13070607
doi: 10.3390/cells13070607
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Halász H
      type: Person
      first name: Henriett
      last name: Halász
      member of: Department of Biophysics, Medical School, University of Pécs, H-7624 Pécs, Hungary.
  slot:
    index: 2
    item: Tárnai V
      type: Person
      first name: Viktória
      last name: Tárnai
      member of: Department of Biophysics, Medical School, University of Pécs, H-7624 Pécs, Hungary.
  slot:
    index: 3
    item: Matkó J
      type: Person
      first name: János
      last name: Matkó
      member of: Department of Immunology, Faculty of Science, Eötvös Loránd University, H-1117 Budapest, Hungary.
  slot:
    index: 4
    item: Nyitrai M
      type: Person
      first name: Miklós
      last name: Nyitrai
      member of: Department of Biophysics, Medical School, University of Pécs, H-7624 Pécs, Hungary.
  slot:
    index: 5
    item: Szabó-Meleg E
      type: Person
      first name: Edina
      last name: Szabó-Meleg
      member of: Department of Biophysics, Medical School, University of Pécs, H-7624 Pécs, Hungary.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-30
dp: 2024 03 30
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D043942Q000737
has primary subject term: D008223Q000378
has primary subject term: D021961
has subject term: D000818
has subject term: D003599Q000378
has subject term: D000199Q000378
has subject term: D008928Q000378
has subject term: D003598Q000378
has subject term: D008322Q000378
source: Cells. 2024-03-30;13(7):.
volume: 13

Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts.
pmid: 38607047
abstract: Cohesin is a highly conserved ring-shaped complex involved in topologically embracing chromatids, gene expression regulation, genome compartmentalization, and genome stability maintenance. Genomic analyses have detected mutations in the cohesin complex in a wide array of human tumors. These findings have led to increased interest in cohesin as a potential target in cancer therapy. Synthetic lethality has been suggested as an approach to exploit genetic differences in cancer cells to influence their selective killing. In this study, we show that mutations in ESCO1, NIPBL, PDS5B, RAD21, SMC1A, SMC3, STAG2, and WAPL genes are synthetically lethal with stimulation of WNT signaling obtained following LY2090314 treatment, a GSK3 inhibitor, in several cancer cell lines. Moreover, treatment led to the stabilization of β-catenin and affected the expression of c-MYC, probably due to the occupancy decrease in cohesin at the c-MYC promoter. Finally, LY2090314 caused gene expression dysregulation mainly involving pathways related to transcription regulation, cell proliferation, and chromatin remodeling. For the first time, our work provides the underlying molecular basis for synthetic lethality due to cohesin mutations and suggests that targeting the WNT may be a promising therapeutic approach for tumors carrying mutated cohesin.
has PII: cells13070608
doi: 10.3390/cells13070608
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Pallotta MM
      type: Person
      first name: Maria Michela
      last name: Pallotta
      member of: Institute for Biomedical Technologies (ITB), National Research Council (CNR), 56124 Pisa, Italy.
  slot:
    index: 2
    item: Di Nardo M
      type: Person
      first name: Maddalena
      last name: Di Nardo
      member of: Institute for Biomedical Technologies (ITB), National Research Council (CNR), 56124 Pisa, Italy.
  slot:
    index: 3
    item: Musio A
      type: Person
      first name: Antonio
      last name: Musio
      member of: Institute for Biomedical Technologies (ITB), National Research Council (CNR), 56124 Pisa, Italy.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-30
dp: 2024 03 30
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: http://id.nlm.nih.gov/mesh/D000097722
has primary subject term: D009369Q000235Q000473
has primary subject term: D006575
has primary subject term: D008301
has subject term: D006801
has subject term: D000072020Q000235
has subject term: D060449Q000235
has subject term: D018797Q000235Q000378
has subject term: D002868Q000235Q000378
has subject term: D038362Q000378
has subject term: D004268Q000378
has subject term: D014157Q000235
source: Cells. 2024-03-30;13(7):.
volume: 13

Polycystin-2 Mediated Calcium Signalling in the Dictyostelium Model for Autosomal Dominant Polycystic Kidney Disease.
pmid: 38607049
abstract: Autosomal dominant polycystic kidney disease (ADPKD) occurs when the proteins Polycystin-1 (PC1, PKD1) and Polycystin-2 (PC2, PKD2) contain mutations. PC1 is a large membrane receptor that can interact and form a complex with the calcium-permeable cation channel PC2. This complex localizes to the plasma membrane, primary cilia and ER. Dysregulated calcium signalling and consequential alterations in downstream signalling pathways in ADPKD are linked to cyst formation and expansion; however, it is not completely understood how PC1 and PC2 regulate calcium signalling. We have studied Polycystin-2 mediated calcium signalling in the model organism Dictyostelium discoideum by overexpressing and knocking down the expression of the endogenous Polycystin-2 homologue, Polycystin-2. Chemoattractant-stimulated cytosolic calcium response magnitudes increased and decreased in overexpression and knockdown strains, respectively, and analysis of the response kinetics indicates that Polycystin-2 is a significant contributor to the control of Ca2+ responses. Furthermore, basal cytosolic calcium levels were reduced in Polycystin-2 knockdown transformants. These alterations in Ca2+ signalling also impacted other downstream Ca2+-sensitive processes including growth rates, endocytosis, stalk cell differentiation and spore viability, indicating that Dictyostelium is a useful model to study Polycystin-2 mediated calcium signalling.
has PII: cells13070610
doi: 10.3390/cells13070610
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Allan CY
      type: Person
      first name: Claire Y
      last name: Allan
      member of: Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia.
  slot:
    index: 2
    item: Sanislav O
      type: Person
      first name: Oana
      last name: Sanislav
      member of: Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia.
  slot:
    index: 3
    item: Fisher PR
      type: Person
      first name: Paul R
      last name: Fisher
      member of: Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, Melbourne, VIC 3086, Australia.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-31
dp: 2024 03 31
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D016891Q000235
has primary subject term: D004023Q000378
has subject term: D006801
has subject term: D050396Q000235
has subject term: D002118Q000378
has subject term: D020013Q000502
has subject term: D015220Q000378
source: Cells. 2024-03-31;13(7):.
volume: 13

Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection.
pmid: 38607055
abstract: The management of chronic myelogenous leukemia (CML) has seen significant progress with the introduction of tyrosine kinase inhibitors (TKIs), particularly Imatinib. However, a notable proportion of CML patients develop resistance to Imatinib, often due to the persistence of leukemia stem cells and resistance mechanisms independent of BCR::ABL1 This study investigates the roles of IL6R, IL7R, and MYC in Imatinib resistance by employing CRISPR/Cas9 for gene editing and the Non-Invasive Apoptosis Detection Sensor version 2 (NIADS v2) for apoptosis assessment. The results indicate that Imatinib-resistant K562 cells (K562-IR) predominantly express IL6R, IL7R, and MYC, with IL6R and MYC playing crucial roles in cell survival and sensitivity to Imatinib. Conversely, IL7R does not significantly impact cytotoxicity, either alone or in combination with Imatinib. Further genetic editing experiments confirm the protective functions of IL6R and MYC in K562-IR cells, suggesting their potential as therapeutic targets for overcoming Imatinib resistance in CML. This study contributes to understanding the mechanisms of Imatinib resistance in CML, proposing IL6R and MYC as pivotal targets for therapeutic strategies. Moreover, the utilization of NIADS v2 enhances our capability to analyze apoptosis and drug responses, contributing to a deeper understanding of CML pathogenesis and treatment options.
has PII: cells13070616
doi: 10.3390/cells13070616
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lee CH
      type: Person
      first name: Chia-Hwa
      last name: Lee
      member of: School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, New Taipei City 23561, Taiwan.Ph.D. Program in Medicine Biotechnology, College of Medical Science and Technology, Taipei Medical University, New Taipei City 23561, Taiwan.TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.
  slot:
    index: 2
    item: Hsu KW
      type: Person
      first name: Kai-Wen
      last name: Hsu
      member of: Research Center for Cancer Biology, China Medical University, Taichung City 40402, Taiwan.Institute of Translational Medicine and New Drug Development, China Medical University, Taichung City 40402, Taiwan.Program for Cancer Biology and Drug Discovery, Drug Development Center, China Medical University, Taichung City 40402, Taiwan.
  slot:
    index: 3
    item: Hsieh YY
      type: Person
      first name: Yao-Yu
      last name: Hsieh
      member of: Division of Hematology and Oncology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
  slot:
    index: 4
    item: Li WT
      type: Person
      first name: Wei-Ting
      last name: Li
      member of: Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 5
    item: Long Y
      type: Person
      first name: Yuqing
      last name: Long
      member of: Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.
  slot:
    index: 6
    item: Lin CY
      type: Person
      first name: Chun-Yu
      last name: Lin
      member of: Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.School of Dentistry, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
  slot:
    index: 7
    item: Chen SH
      type: Person
      first name: Shu-Huey
      last name: Chen
      member of: Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-02
dp: 2024 04 02
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D015415
has primary subject term: D015464Q000188Q000235Q000473
has primary subject term: D019947
has primary subject term: D016271
has subject term: D006801
has subject term: D017209
has subject term: D019008
has subject term: D000068877Q000494Q000627
has subject term: D047428Q000494Q000627
source: Cells. 2024-04-02;13(7):.
volume: 13

Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis.
pmid: 38607051
abstract: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) featuring numerous neuropathologies, including optic neuritis (ON) in some patients. However, the molecular mechanisms of ON remain unknown. Galectins, β-galactoside-binding lectins, are involved in various pathophysiological processes. We previously showed that galectin-3 (gal-3) is associated with the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. In the current study, we investigated the expression of gal-3 in the visual pathway in EAE mice to clarify its role in the pathogenesis of ON. Immunohistochemical analysis revealed upregulation of gal-3 in the visual pathway of the EAE mice during the peak stage of the disease, compared with naïve and EAE mice during the chronic stage. Gal-3 was detected mainly in microglia/macrophages and astrocytes in the visual pathway in EAE mice. In addition, gal-3+/Iba-1+ cells, identified as phagocytic by immunostaining for cathepsin D, accumulated in demyelinating lesions in the visual pathway during the peak disease stage of EAE. Moreover, NLRP3 expression was detected in most gal-3+/Iba-1+ cells. These results strongly suggest that gal-3 regulates NLRP3 signaling in microglia/macrophages and neuroinflammatory demyelination in ON. In astrocytes, gal-3 was expressed from the peak to the chronic disease stages. Taken together, our findings suggest a critical role of gal-3 in the pathogenesis of ON. Thus, gal-3 in glial cells may serve as a potential therapeutic target for ON.
has PII: cells13070612
doi: 10.3390/cells13070612
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Funaki M
      type: Person
      first name: Masako
      last name: Funaki
      member of: Department of Anatomy, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
  slot:
    index: 2
    item: Nio-Kobayashi J
      type: Person
      first name: Junko
      last name: Nio-Kobayashi
      member of: Department of Functional Glycobiology in Infectious Diseases, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki 852-8523, Japan.
  slot:
    index: 3
    item: Suzuki R
      type: Person
      first name: Ryoji
      last name: Suzuki
      member of: Department of Anatomy, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
  slot:
    index: 4
    item: Bando Y
      type: Person
      first name: Yoshio
      last name: Bando
      member of: Department of Anatomy, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-31
dp: 2024 03 31
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D037502Q000378
has primary subject term: D009902Q000473
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D004681Q000473
has subject term: D037161Q000378
has subject term: D009103Q000473
has subject term: http://id.nlm.nih.gov/mesh/D000090862
has subject term: http://id.nlm.nih.gov/mesh/D000071199
has subject term: D014795Q000473
source: Cells. 2024-03-31;13(7):.
volume: 13

The Role of the NLRP3 Inflammasome in the Molecular and Biochemical Mechanisms of Cervical Ripening: A Comprehensive Review.
pmid: 38607039
abstract: The uterine cervix is one of the key factors involved in ensuring a proper track of gestation and labor. At the end of the gestational period, the cervix undergoes extensive changes, which can be summarized as a transformation from a non-favorable cervix to one that is soft and prone to dilation. During a process called cervical ripening, fundamental remodeling of the cervical extracellular matrix (ECM) occurs. The cervical ripening process is a derivative of many interlocking and mutually driving biochemical and molecular pathways under the strict control of mediators such as inflammatory cytokines, nitric oxide, prostaglandins, and reactive oxygen species. A thorough understanding of all these pathways and learning about possible triggering factors will allow us to develop new, better treatment algorithms and therapeutic goals that could protect women from both dysfunctional childbirth and premature birth. This review aims to present the possible role of the NLRP3 inflammasome in the cervical ripening process, emphasizing possible mechanisms of action and regulatory factors.
has PII: cells13070600
doi: 10.3390/cells13070600
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Flis W
      type: Person
      first name: Wojciech
      last name: Flis
      member of: Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Łukasiewicza 1, 85-821 Bydgoszcz, Poland.Department of Obstetrics and Gynecology, St. Adalbert's Hospital in Gdańsk, Copernicus Healthcare Entity, Jana Pawła II 50, 80-462 Gdańsk, Poland.
  slot:
    index: 2
    item: Socha MW
      type: Person
      first name: Maciej W
      last name: Socha
      member of: Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Łukasiewicza 1, 85-821 Bydgoszcz, Poland.Department of Obstetrics and Gynecology, St. Adalbert's Hospital in Gdańsk, Copernicus Healthcare Entity, Jana Pawła II 50, 80-462 Gdańsk, Poland.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-29
dp: 2024 03 29
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D020070Q000378
has primary subject term: D047928
has subject term: D011247
has subject term: D005260
has subject term: D006801
has subject term: D058847
has subject term: http://id.nlm.nih.gov/mesh/D000071199
has subject term: D036801
source: Cells. 2024-03-29;13(7):.
volume: 13

Spotlight on New Hallmarks of Drug-Resistance towards Personalized Care for Epithelial Ovarian Cancer.
pmid: 38607050
abstract: Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy worldwide. Despite the latest advances, a major clinical issue in EOC is the disappointing prognosis related to chemoresistance in almost one-third of cases. Drug resistance relies on heterogeneous cancer stem cells (CSCs), endowed with tumor-initiating potential, leading to relapse. No biomarkers of chemoresistance have been validated yet. Recently, major signaling pathways, micro ribonucleic acids (miRNAs), and circulating tumor cells (CTCs) have been advocated as putative biomarkers and potential therapeutic targets for drug resistance. However, further investigation is mandatory before their routine implementation. In accordance with the increasing rate of therapeutic efforts in EOC, the need for biomarker-driven personalized therapies is growing. This review aims to discuss the emerging hallmarks of drug resistance with an in-depth insight into the underlying molecular mechanisms lacking so far. Finally, a glimpse of novel therapeutic avenues and future challenges will be provided.
has PII: cells13070611
doi: 10.3390/cells13070611
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Frezzini S
      type: Person
      first name: Simona
      last name: Frezzini
      member of: Unit of Medical Oncology 3, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.
  slot:
    index: 2
    item: Lonardi S
      type: Person
      first name: Sara
      last name: Lonardi
      member of: Unit of Medical Oncology 3, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-03-31
dp: 2024 03 31
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D010051Q000188Q000235Q000378
has subject term: D006801
has subject term: D005260
has subject term: D000077216Q000188Q000378
has subject term: D019008
has subject term: D009364
has subject term: D015398
has subject term: D015415
source: Cells. 2024-03-31;13(7):.
volume: 13

The Triple Adipose-Derived Stem Cell Exosome Technology as a Potential Tool for Treating Triple-Negative Breast Cancer.
pmid: 38607053
abstract: Extracellular vesicles are pivotal mediators in intercellular communication, facilitating the exchange of biological information among healthy, pathological and tumor cells. Between the diverse subtypes of extracellular vesicles, exosomes have unique properties and clinical and therapeutical applications. Breast cancer ranks as one of the most prevalent malignancies across the globe. Both the tumor core and its surrounding microenvironment engage in a complex, orchestrated interaction that facilitates cancer's growth and spread.The most significant PubMed literature about extracellular vesicles and Adipose-Derived Stem Cell Exosomes and breast cancer was selected in order to report their biological properties and potential applications, in particular in treating triple-negative breast cancer.Adipose-Derived Stem Cell Exosomes represent a potential tool in targeting triple-negative breast cancer cells at three main levels: the tumor core, the tumor microenvironment and surrounding tissues, including metastases.The possibility of impacting triple-negative breast cancer cells with engineered Adipose-Derived Stem Cell Exosomes is real. The opportunity to translate our current in vitro analyses into a future in vivo scenario is even more challenging.
has PII: cells13070614
doi: 10.3390/cells13070614
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Pagani A
      type: Person
      first name: Andrea
      last name: Pagani
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 2
    item: Duscher D
      type: Person
      first name: Dominik
      last name: Duscher
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 3
    item: Geis S
      type: Person
      first name: Sebastian
      last name: Geis
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 4
    item: Klein S
      type: Person
      first name: Silvan
      last name: Klein
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 5
    item: Knoedler L
      type: Person
      first name: Leonard
      last name: Knoedler
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 6
    item: Panayi AC
      type: Person
      first name: Adriana C
      last name: Panayi
      member of: Department of Plastic, Hand and Reconstructive Surgery, BG Klinik Ludwigshafen, University of Heidelberg, Ludwig-Guttmann-Straße 13, 67071 Ludwigshafen, Germany.
  slot:
    index: 7
    item: Oliinyk D
      type: Person
      first name: Dmytro
      last name: Oliinyk
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 8
    item: Felthaus O
      type: Person
      first name: Oliver
      last name: Felthaus
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
  slot:
    index: 9
    item: Prantl L
      type: Person
      first name: Lukas
      last name: Prantl
      member of: Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-02
dp: 2024 04 02
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D055354
has primary subject term: D064726Q000628
has primary subject term: http://id.nlm.nih.gov/mesh/D000067128
has subject term: D006801
has subject term: D017667
has subject term: D013234
has subject term: D059016
source: Cells. 2024-04-02;13(7):.
volume: 13

The Natural Product Secoemestrin C Inhibits Colorectal Cancer Stem Cells via p38-S100A8 Feed-Forward Regulatory Loop.
pmid: 38607060
abstract: Cancer stem cells (CSCs) are closely associated with tumor initiation, metastasis, chemoresistance, and recurrence, which represent some of the primary obstacles to cancer treatment. Targeting CSCs has become an important therapeutic approach to cancer care. Secoemestrin C (Sec C) is a natural compound with strong anti-tumor activity and low toxicity. Here, we report that Sec C effectively inhibited colorectal CSCs and non-CSCs concurrently, mainly by inhibiting proliferation, self-renewal, metastasis, and drug resistance. Mechanistically, RNA-seq analysis showed that the pro-inflammation pathway of the IL17 axis was enriched, and its effector S100A8 was dramatically decreased in Sec C-treated cells, whose roles in the stemness of CSCs have not been fully clarified. We found that the overexpression of S100A8 hindered the anti-CSCs effect of Sec C, and S100A8 deficiency attenuated the stemness traits of CSCs to enhance the Sec C killing activity on them. Meanwhile, the p38 signal pathway, belonging to the IL17 downstream axis, can also mediate CSCs and counter with Sec C. Notably, we found that S100A8 upregulation increased the p38 protein level, and p38, in turn, promoted S100A8 expression. This indicated that p38 may have a mutual feedback loop with S100A8. Our study discovered that Sec C was a powerful anti-colorectal CSC agent, and that the positive feedback loop of p38-S100A8 mediated Sec C activity. This showed that Sec C could act as a promising clinical candidate in colorectal cancer treatment, and S100A8 could be a prospective drug target.
has PII: cells13070620
doi: 10.3390/cells13070620
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zhou H
      type: Person
      first name: Huimin
      last name: Zhou
      member of: State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 2
    item: Chen M
      type: Person
      first name: Minghua
      last name: Chen
      member of: NHC Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China.
  slot:
    index: 3
    item: Zhao C
      type: Person
      first name: Cong
      last name: Zhao
      member of: State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 4
    item: Shao R
      type: Person
      first name: Rongguang
      last name: Shao
      member of: State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 5
    item: Xu Y
      type: Person
      first name: Yanni
      last name: Xu
      member of: NHC Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China.
  slot:
    index: 6
    item: Zhao W
      type: Person
      first name: Wuli
      last name: Zhao
      member of: State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-04-03
dp: 2024 04 03
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D015398
has primary subject term: D015179Q000473
has subject term: D006801
has subject term: D002471Q000378
has subject term: D015854
has subject term: D014411Q000473
source: Cells. 2024-04-03;13(7):.
volume: 13

The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases.
pmid: 38607048
abstract: Cardiolipin (CL) is a mitochondria-exclusive phospholipid synthesized in the inner mitochondrial membrane. CL plays a key role in mitochondrial membranes, impacting a plethora of functions this organelle performs. Consequently, it is conceivable that abnormalities in the CL content, composition, and level of oxidation may negatively impact mitochondrial function and dynamics, with important implications in a variety of diseases. This review concentrates on papers published in recent years, combined with basic and underexplored research in CL. We capture new findings on its biological functions in the mitochondria, as well as its association with neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease. Lastly, we explore the potential applications of CL as a biomarker and pharmacological target to mitigate mitochondrial dysfunction.
has PII: cells13070609
doi: 10.3390/cells13070609
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Fuentes JM
      type: Person
      first name: José M
      last name: Fuentes
      member of: Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, 10003 Cáceres, Spain.Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain.Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain.
  slot:
    index: 2
    item: Morcillo P
      type: Person
      first name: Patricia
      last name: Morcillo
      member of: Departmentof Neurology, Columbia University, New York, NY 10032, USA.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-03-30
dp: 2024 03 30
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D019636Q000378
has primary subject term: D010300Q000378
has subject term: D006801
has subject term: D002308Q000378
has subject term: D008928
has subject term: D051336Q000378
source: Cells. 2024-03-30;13(7):.
volume: 13

Dilation of Pregnant Rat Uterine Arteries with Phenols from Extra Virgin Olive Oil Is Endothelium-Dependent and Involves Calcium and Potassium Channels.
pmid: 38607058
abstract: During pregnancy, uterine vasculature undergoes significant circumferential growth to increase uterine blood flow, vital for the growing feto-placental unit. However, this process is often compromised in conditions like maternal high blood pressure, particularly in preeclampsia (PE), leading to fetal growth impairment. Currently, there is no cure for PE, partly due to the adverse effects of anti-hypertensive drugs on maternal and fetal health. This study aimed to investigate the vasodilator effect of extra virgin olive oil (EVOO) phenols on the reproductive vasculature, potentially benefiting both mother and fetus. Isolated uterine arteries (UAs) from pregnant rats were tested with EVOO phenols in a pressurized myograph. To elucidate the underlying mechanisms, additional experiments were conducted with specific inhibitors: L-NAME/L-NNA (10-4 M) for nitric oxide synthases, ODQ (10-5 M) for guanylate cyclase, Verapamil (10-5 M) for the L-type calcium channel, Ryanodine (10-5 M) + 2-APB (3 × 10-5 M) for ryanodine and the inositol triphosphate receptors, respectively, and Paxilline (10-5 M) for the large-conductance calcium-activated potassium channel. The results indicated that EVOO-phenols activate Ca2+ signaling pathways, generating nitric oxide, inducing vasodilation via cGMP and BKCa2+ signals in smooth muscle cells. This study suggests the potential use of EVOO phenols to prevent utero-placental blood flow restriction, offering a promising avenue for managing PE.
has PII: cells13070619
doi: 10.3390/cells13070619
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Esposito M
      type: Person
      first name: Milena
      last name: Esposito
      member of: Department of Biology, Ecology & Earth Science, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.
  slot:
    index: 2
    item: Gatto M
      type: Person
      first name: Mariacarmela
      last name: Gatto
      member of: Department of Biology, Ecology & Earth Science, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.
  slot:
    index: 3
    item: Cipolla MJ
      type: Person
      first name: Marilyn J
      last name: Cipolla
      member of: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Larner College of Medicine, Burlington, VT 05405, USA.Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT 05405, USA.
  slot:
    index: 4
    item: Bernstein IM
      type: Person
      first name: Ira M
      last name: Bernstein
      member of: Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT 05405, USA.
  slot:
    index: 5
    item: Mandalà M
      type: Person
      first name: Maurizio
      last name: Mandalà
      member of: Department of Biology, Ecology & Earth Science, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Larner College of Medicine, Burlington, VT 05405, USA.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-02
dp: 2024 04 02
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D055988Q000378
has primary subject term: D002118Q000378
has subject term: D051381
has subject term: D011247
has subject term: D005260
has subject term: D000818
has subject term: D000069463Q000494
has subject term: D009569Q000378
has subject term: D010920Q000378
has subject term: D012433
has subject term: D010636Q000494
has subject term: D004106
has subject term: D051036Q000378
has subject term: D004727Q000378
source: Cells. 2024-04-02;13(7):.
volume: 13

Mesenchymal-Stem-Cell-Based Therapy against Gliomas.
pmid: 38607056
abstract: Glioblastoma is the most aggressive, malignant, and lethal brain tumor of the central nervous system. Its poor prognosis lies in its inefficient response to currently available treatments that consist of surgical resection, radiotherapy, and chemotherapy. Recently, the use of mesenchymal stem cells (MSCs) as a possible kind of cell therapy against glioblastoma is gaining great interest due to their immunomodulatory properties, tumor tropism, and differentiation into other cell types. However, MSCs seem to present both antitumor and pro-tumor properties depending on the tissue from which they come. In this work, the possibility of using MSCs to deliver therapeutic genes, oncolytic viruses, and miRNA is presented, as well as strategies that can improve their therapeutic efficacy against glioblastoma, such as CAR-T cells, nanoparticles, and exosomes.
has PII: cells13070617
doi: 10.3390/cells13070617
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Santillán-Guaján SM
      type: Person
      first name: Sisa M
      last name: Santillán-Guaján
      member of: Department of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain.
  slot:
    index: 2
    item: Shahi MH
      type: Person
      first name: Mehdi H
      last name: Shahi
      member of: Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, India.
  slot:
    index: 3
    item: Castresana JS
      type: Person
      first name: Javier S
      last name: Castresana
      member of: Department of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-02
dp: 2024 04 02
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D005909Q000378
has primary subject term: D045164
has primary subject term: D005910Q000378
has primary subject term: D001932Q000378
has primary subject term: D059630Q000378
has subject term: D006801
source: Cells. 2024-04-02;13(7):.
volume: 13

The Olfactory Trail of Neurodegenerative Diseases.
pmid: 38607054
abstract: Alterations in olfactory functions are proposed as possible early biomarkers of neurodegenerative diseases. Parkinson's and Alzheimer's diseases manifest olfactory dysfunction as a symptom, which is worth mentioning. The alterations do not occur in all patients, but they can serve to rule out neurodegenerative pathologies that are not associated with small deficits. Several prevalent neurodegenerative conditions, including impaired smell, arise in the early stages of Parkinson's and Alzheimer's diseases, presenting an attractive prospect as a snitch for early diagnosis. This review covers the current knowledge on the link between olfactory deficits and Parkinson's and Alzheimer's diseases. The review also covers the emergence of olfactory receptors as actors in the pathophysiology of these diseases. Olfactory receptors are not exclusively expressed in olfactory sensory neurons. Olfactory receptors are widespread in the human body; they are expressed, among others, in the testicles, lungs, intestines, kidneys, skin, heart, and blood cells. Although information on these ectopically expressed olfactory receptors is limited, they appear to be involved in cell recognition, migration, proliferation, wound healing, apoptosis, and exocytosis. Regarding expression in non-chemosensory regions of the central nervous system (CNS), future research should address the role, in both the glia and neurons, of olfactory receptors. Here, we review the limited but relevant information on the altered expression of olfactory receptor genes in Parkinson's and Alzheimer's diseases. By unraveling how olfactory receptor activation is involved in neurodegeneration and identifying links between olfactory structures and neuronal death, valuable information could be gained for early diagnosis and intervention strategies in neurodegenerative diseases.
has PII: cells13070615
doi: 10.3390/cells13070615
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Franco R
      type: Person
      first name: Rafael
      last name: Franco
      member of: Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.CiberNed, Network Center for Neurodegenerative Diseases, National Spanish Health Institute Carlos III, 28029 Madrid, Spain.School of Chemistry, University of Barcelona, 08028 Barcelona, Spain.
  slot:
    index: 2
    item: Garrigós C
      type: Person
      first name: Claudia
      last name: Garrigós
      member of: Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.
  slot:
    index: 3
    item: Lillo J
      type: Person
      first name: Jaume
      last name: Lillo
      member of: Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.CiberNed, Network Center for Neurodegenerative Diseases, National Spanish Health Institute Carlos III, 28029 Madrid, Spain.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-02
dp: 2024 04 02
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D019636Q000473
has primary subject term: D000544Q000378
has primary subject term: D010300Q000378
has primary subject term: D000857Q000175
has primary subject term: D018035
has subject term: D006801
has subject term: D012903Q000502
source: Cells. 2024-04-02;13(7):.
volume: 13

The Role of Semaphorins in the Pathogenesis of Rheumatoid Arthritis.
pmid: 38607057
abstract: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Inflammation of the synovial fluid propagates the pathological process of angiogenesis. Semaphorins play a crucial role in the context of endothelial cell function, and their pleiotropic nature has various effects on the further development of RA. This narrative review summarises the various roles of semaphorins in the pathology of RA and whether they could play a role in developing novel RA treatment options.
has PII: cells13070618
doi: 10.3390/cells13070618
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Rosik J
      type: Person
      first name: Jakub
      last name: Rosik
      member of: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  slot:
    index: 2
    item: Kulpa J
      type: Person
      first name: Joanna
      last name: Kulpa
      member of: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  slot:
    index: 3
    item: Szczepanik M
      type: Person
      first name: Marcin
      last name: Szczepanik
      member of: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
  slot:
    index: 4
    item: Pawlik A
      type: Person
      first name: Andrzej
      last name: Pawlik
      member of: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-02
dp: 2024 04 02
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D039961
has primary subject term: D001172
has primary subject term: D001327
has subject term: D006801
has subject term: D007249
has subject term: D013582
source: Cells. 2024-04-02;13(7):.
volume: 13

A New Immortalized Human Lacrimal Gland Cell Line.
pmid: 38607061
abstract: The lacrimal gland is crucial for maintaining ocular health by producing the aqueous component of the tear film, which hydrates and nourishes the ocular surface. Decreased production of this component results in dry eye disease, a condition affecting over 250 million people worldwide. However, the scarcity of primary human material for studying its underlying mechanisms and the absence of a cell model for human lacrimal gland epithelial cells present significant challenges. Here, we describe the generation of immortalized human lacrimal gland cell lines through the introduction of an SV40 antigen. We successfully isolated and characterized three cell clones from a female lacrimal gland donor, confirming their epithelial identity through genomic and protein analyses, including PCR, RNAseq, immunofluorescence and cultivation in a 3D spheroid model. Our findings represent a significant advancement, providing improved accessibility to investigate the molecular pathogenesis mechanisms of dry eye disease and potential therapeutic interventions. We identified the expression of typical epithelial cell marker genes and demonstrated the cells' capability to form 2D cell sheets and 3D spheroids. This establishment of immortalized human lacrimal gland cells with epithelial characteristics holds promise for future comprehensive studies, contributing to a deeper understanding of dry eye disease and its cellular mechanisms.
has PII: cells13070622
doi: 10.3390/cells13070622
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Gleixner S
      type: Person
      first name: Sophie
      last name: Gleixner
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 2
    item: Zahn I
      type: Person
      first name: Ingrid
      last name: Zahn
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 3
    item: Dietrich J
      type: Person
      first name: Jana
      last name: Dietrich
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 4
    item: Singh S
      type: Person
      first name: Swati
      last name: Singh
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.Hariram Motumal Nasta & Renu Hariram Nasta Ophthalmic Plastic Surgery Services, LV Prasad Eye Institute, Hyderabad 500034, India.
  slot:
    index: 5
    item: Drobny A
      type: Person
      first name: Alice
      last name: Drobny
      member of: Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 6
    item: Schneider Y
      type: Person
      first name: Yanni
      last name: Schneider
      member of: Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 7
    item: Schwendner R
      type: Person
      first name: Raphael
      last name: Schwendner
      member of: Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 8
    item: Socher E
      type: Person
      first name: Eileen
      last name: Socher
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 9
    item: Blavet N
      type: Person
      first name: Nicolas
      last name: Blavet
      member of: CEITEC-Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
  slot:
    index: 10
    item: Bräuer L
      type: Person
      first name: Lars
      last name: Bräuer
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 11
    item: Gostian AO
      type: Person
      first name: Antoniu-Oreste
      last name: Gostian
      member of: Department of Otorhinolaryngology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, Germany.Department of Otolaryngology, Head & Neck Surgery, Comprehensive Cancer Center Erlangen, University Hospital Erlangen, 91054 Erlangen, Germany.
  slot:
    index: 12
    item: Balk M
      type: Person
      first name: Matthias
      last name: Balk
      member of: Department of Otolaryngology, Head & Neck Surgery, Comprehensive Cancer Center Erlangen, University Hospital Erlangen, 91054 Erlangen, Germany.
  slot:
    index: 13
    item: Schulze-Tanzil G
      type: Person
      first name: Gundula
      last name: Schulze-Tanzil
      member of: Institute of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg Prof. Ernst Nathan Str. 1, 90419 Nuremberg, Germany.
  slot:
    index: 14
    item: Günther C
      type: Person
      first name: Claudia
      last name: Günther
      member of: Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 15
    item: Paulsen F
      type: Person
      first name: Friedrich
      last name: Paulsen
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  slot:
    index: 16
    item: Arnold P
      type: Person
      first name: Philipp
      last name: Arnold
      member of: Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-03
dp: 2024 04 03
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D007765Q000378
has primary subject term: D015352Q000378
has subject term: D006801
has subject term: D005260
has subject term: D013666Q000378
has subject term: D002460
source: Cells. 2024-04-03;13(7):.
volume: 13

Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes.
pmid: 38607062
abstract: Limbal epithelial progenitor cells (LEPC) rely on their niche environment for proper functionality and self-renewal. While extracellular vesicles (EV), specifically small EVs (sEV), have been proposed to support LEPC homeostasis, data on sEV derived from limbal niche cells like limbal mesenchymal stromal cells (LMSC) remain limited, and there are no studies on sEVs from limbal melanocytes (LM). In this study, we isolated sEV from conditioned media of LMSC and LM using a combination of tangential flow filtration and size exclusion chromatography and characterized them by nanoparticle tracking analysis, transmission electron microscopy, Western blot, multiplex bead arrays, and quantitative mass spectrometry. The internalization of sEV by LEPC was studied using flow cytometry and confocal microscopy. The isolated sEVs exhibited typical EV characteristics, including cell-specific markers such as CD90 for LMSC-sEV and Melan-A for LM-sEV. Bioinformatics analysis of the proteomic data suggested a significant role of sEVs in extracellular matrix deposition, with LMSC-derived sEV containing proteins involved in collagen remodeling and cell matrix adhesion, whereas LM-sEV proteins were implicated in other cellular bioprocesses such as cellular pigmentation and development. Moreover, fluorescently labeled LMSC-sEV and LM-sEV were taken up by LEPC and localized to their perinuclear compartment. These findings provide valuable insights into the complex role of sEV from niche cells in regulating the human limbal stem cell niche.
has PII: cells13070623
doi: 10.3390/cells13070623
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Kistenmacher S
      type: Person
      first name: Sebastian
      last name: Kistenmacher
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
  slot:
    index: 2
    item: Schwämmle M
      type: Person
      first name: Melanie
      last name: Schwämmle
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany.
  slot:
    index: 3
    item: Martin G
      type: Person
      first name: Gottfried
      last name: Martin
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
  slot:
    index: 4
    item: Ulrich E
      type: Person
      first name: Eva
      last name: Ulrich
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
  slot:
    index: 5
    item: Tholen S
      type: Person
      first name: Stefan
      last name: Tholen
      member of: Institute of Surgical Pathology, Faculty of Medicine, Freiburg, Medical Center, University of Freiburg, 79085 Freiburg im Breisgau, Germany.
  slot:
    index: 6
    item: Schilling O
      type: Person
      first name: Oliver
      last name: Schilling
      member of: Institute of Surgical Pathology, Faculty of Medicine, Freiburg, Medical Center, University of Freiburg, 79085 Freiburg im Breisgau, Germany.
  slot:
    index: 7
    item: Gießl A
      type: Person
      first name: Andreas
      last name: Gießl
      member of: Department of Ophthalmology, University Hospital Erlangen, Friedrich-Alexander-University of Erlan-gen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany.
  slot:
    index: 8
    item: Schlötzer-Schrehardt U
      type: Person
      first name: Ursula
      last name: Schlötzer-Schrehardt
      member of: Department of Ophthalmology, University Hospital Erlangen, Friedrich-Alexander-University of Erlan-gen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany.
  slot:
    index: 9
    item: Bucher F
      type: Person
      first name: Felicitas
      last name: Bucher
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
  slot:
    index: 10
    item: Schlunck G
      type: Person
      first name: Günther
      last name: Schlunck
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
  slot:
    index: 11
    item: Nazarenko I
      type: Person
      first name: Irina
      last name: Nazarenko
      member of: Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany.
  slot:
    index: 12
    item: Reinhard T
      type: Person
      first name: Thomas
      last name: Reinhard
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
  slot:
    index: 13
    item: Polisetti N
      type: Person
      first name: Naresh
      last name: Polisetti
      member of: Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D059630Q000378
has primary subject term: D000067128Q000378
has subject term: D006801
has subject term: D040901Q000379
has subject term: D013234
has subject term: D008544
source: Cells. 2024-04-04;13(7):.
volume: 13

From Vessels to Neurons-The Role of Hypoxia Pathway Proteins in Embryonic Neurogenesis.
pmid: 38607059
abstract: Embryonic neurogenesis can be defined as a period of prenatal development during which divisions of neural stem and progenitor cells give rise to neurons. In the central nervous system of most mammals, including humans, the majority of neocortical neurogenesis occurs before birth. It is a highly spatiotemporally organized process whose perturbations lead to cortical malformations and dysfunctions underlying neurological and psychiatric pathologies, and in which oxygen availability plays a critical role. In case of deprived oxygen conditions, known as hypoxia, the hypoxia-inducible factor (HIF) signaling pathway is activated, resulting in the selective expression of a group of genes that regulate homeostatic adaptations, including cell differentiation and survival, metabolism and angiogenesis. While a physiological degree of hypoxia is essential for proper brain development, imbalanced oxygen levels can adversely affect this process, as observed in common obstetrical pathologies such as prematurity. This review comprehensively explores and discusses the current body of knowledge regarding the role of hypoxia and the HIF pathway in embryonic neurogenesis of the mammalian cortex. Additionally, it highlights existing gaps in our understanding, presents unanswered questions, and provides avenues for future research.
has PII: cells13070621
doi: 10.3390/cells13070621
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Stepien BK
      type: Person
      first name: Barbara K
      last name: Stepien
      member of: Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
  slot:
    index: 2
    item: Wielockx B
      type: Person
      first name: Ben
      last name: Wielockx
      member of: Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.Experimental Centre, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-03
dp: 2024 04 03
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D058953Q000378
has subject term: D006801
has subject term: D000818
has subject term: D011247
has subject term: D005260
has subject term: D009474Q000378
has subject term: D055495Q000235
has subject term: D000860Q000378
has subject term: D010100Q000378
has subject term: D008322
source: Cells. 2024-04-03;13(7):.
volume: 13

Paternal Age Amplifies Cryopreservation-Induced Stress in Human Spermatozoa.
pmid: 38607064
abstract: The global fall in male fertility is a complicated process driven by a variety of factors, including environmental exposure, lifestyle, obesity, stress, and aging. The availability of assisted reproductive technology (ART) has allowed older couples to conceive, increasing the average paternal age at first childbirth. Advanced paternal age (APA), most often considered male age ≥40, has been described to impact several aspects of male reproductive physiology. In this prospective cohort study including 200 normozoospermic patients, 105 of whom were ≤35 years (non-APA), and 95 of whom were ≥42 years (APA), we assessed the impact of paternal age on different endpoints representative of sperm quality and cryopreservation tolerance. Non-APA patients had superior fresh semen quality; DNA fragmentation was notably increased in APA as compared to non-APA individuals (21.7% vs. 15.4%). Cryopreservation further increased the DNA fragmentation index in APA (26.7%) but not in non-APA patients. Additionally, APA was associated with increased mtDNAcn in both fresh and frozen/thawed sperm, which is indicative of poorer mitochondrial quality. Cryopreservation negatively impacted acrosome integrity in both age groups, as indicated by reduced incidences of unreacted acrosome in relation to fresh counterparts in non-APA (from 71.5% to 57.7%) and APA patients (from 75% to 63%). Finally, cryopreservation significantly reduced the phosphorylation status of proteins containing tyrosine residues in sperm from young males. Therefore, the present findings shed light on the effects of paternal age and cryopreservation on sperm quality and serve as valuable new parameters to improve our understanding of the mechanisms underlying sperm developmental competence that are under threat in current ART practice.
has PII: cells13070625
doi: 10.3390/cells13070625
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Pérez Casasús S
      type: Person
      first name: Silvia
      last name: Pérez Casasús
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 2
    item: Luongo FP
      type: Person
      first name: Francesca Paola
      last name: Luongo
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 3
    item: Haxhiu A
      type: Person
      first name: Alesandro
      last name: Haxhiu
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 4
    item: Orini M
      type: Person
      first name: Martina
      last name: Orini
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 5
    item: Scupoli G
      type: Person
      first name: Giorgia
      last name: Scupoli
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 6
    item: Governini L
      type: Person
      first name: Laura
      last name: Governini
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 7
    item: Piomboni P
      type: Person
      first name: Paola
      last name: Piomboni
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
  slot:
    index: 8
    item: Buratini J
      type: Person
      first name: Jose
      last name: Buratini
      member of: Biogenesi Reproductive Medicine Center, Istituti Clinici Zucchi, 20900 Monza, Italy.
  slot:
    index: 9
    item: Dal Canto M
      type: Person
      first name: Mariabeatrice
      last name: Dal Canto
      member of: Biogenesi Reproductive Medicine Center, Istituti Clinici Zucchi, 20900 Monza, Italy.
  slot:
    index: 10
    item: Luddi A
      type: Person
      first name: Alice
      last name: Luddi
      member of: Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D055101
has primary subject term: D010331
has subject term: D006801
has subject term: D008297
has subject term: D011446
has subject term: D012661
has subject term: D013081Q000502
has subject term: D013094Q000502
has subject term: D015925
source: Cells. 2024-04-04;13(7):.
volume: 13

SMAD4-Dependent Signaling Pathway Involves in the Pathogenesis of TGFBR2-Related CE-like Phenotype.
pmid: 38607065
abstract: (1) Background: Our previous data indicated that disturbance of the Transforming Growth Factor beta (TGFB) signaling pathway via its Type-2 Receptor (TGFBR2) can cause a Corneal Ectasia (CE)-like phenotype. The purpose of this study is to elucidate whether the SMAD4-dependent signaling pathway is involved in the TGFBR2-related CE-like pathogenesis. (2) Methods: Smad4 was designed to be conditionally knocked out from keratocytes. Novel triple transgenic mice, KerartTA; Tet-O-Cre; Smad4flox/flox (Smad4kera-cko), were administered with doxycycline (Dox). Optical Coherence Tomography (OCT) was performed to examine Central Corneal Thickness (CCT), Corneal Radius, Anterior Chamber and CE-like phenotype and compared to the littermate Control group (Smad4Ctrl). (3) Results: The OCT revealed normal cornea in the Smad4Ctrl and a CE-like phenotype in the Smad4kera-cko cornea, in which the overall CCT in Smad4kera-cko was thinner than that of Smad4Ctrl at P42 (n = 6, p < 0.0001) and showed no significant difference when compared to that in Tgfbr2kera-cko. Furthermore, the measurements of the Anterior Chamber and Corneal Radius indicated a substantial ectatic cornea in the Smad4kera-cko compared to Smad4Ctrl. The H&E staining of Smad4kera-cko mimics the finding in the Tgfbr2kera-cko. The positive immunostaining of cornea-specific marker K12 indicating the cell fate of cornea epithelium remained unchanged in Smad4kera-cko and the Proliferating Cell Nuclear Antigen (PCNA) immunostaining further indicated an enhanced proliferation in the Smad4kera-cko. Both immunostainings recapitulated the finding in Tgfbr2kera-cko. The Masson's Trichrome staining revealed decreased collagen formation in the corneal stroma from both Smad4kera-cko and Tgfbr2kera-cko. The collagen type 1 (Col1a1) immunostaining further confirmed the reduction in collagen type 1 formation in Smad4kera-cko. (4) Conclusions: The aforementioned phenotypes in the Smad4kera-cko strain indicated that the SMAD4-dependent si[cell cut: 2100 characters, first 2000 kept]
has PII: cells13070626
doi: 10.3390/cells13070626
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wang YC
      type: Person
      first name: Yen-Chiao
      last name: Wang
      member of: Edith Crawley Vision Research Center, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.Department of Anesthesia, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.School of Optometry, Indiana University, Bloomington, IN 47405, USA.
  slot:
    index: 2
    item: Zolnik OB
      type: Person
      first name: Olivia Betty
      last name: Zolnik
      member of: School of Optometry, Indiana University, Bloomington, IN 47405, USA.
  slot:
    index: 3
    item: Liu CY
      type: Person
      first name: Chia-Yang
      last name: Liu
      member of: Edith Crawley Vision Research Center, Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.School of Optometry, Indiana University, Bloomington, IN 47405, USA.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D003316Q000473
has subject term: D051379
has subject term: D000818
has subject term: D000077294Q000235
has subject term: D008822
has subject term: D015398
has subject term: D010641
has subject term: D003094
source: Cells. 2024-04-04;13(7):.
volume: 13

Role of the Skin Immune System in Wound Healing.
pmid: 38607063
abstract: Wound healing is a dynamic and complex process, characterized by the coordinated activities of multiple cell types, each with distinct roles in the stages of hemostasis, inflammation, proliferation, and remodeling. The cells of the immune system not only act as sentinels to monitor the skin and promote homeostasis, but they also play an important role in the process of skin wound repair. Skin-resident and recruited immune cells release cytokines and growth factors that promote the amplification of the inflammatory process. They also work with non-immune cells to remove invading pathogens and debris, as well as guide the regeneration of damaged host tissues. Dysregulation of the immune system at any stage of the process may lead to a prolongation of the inflammatory phase and the development of a pathological condition, such as a chronic wound. The present review aims to summarize the roles of different immune cells, with special emphasis on the different stages of the wound healing process.
has PII: cells13070624
doi: 10.3390/cells13070624
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Cioce A
      type: Person
      first name: Angela
      last name: Cioce
      member of: National Institute for Health, Migration and Poverty INMP/NIHMP, Via di S.Gallicano, 25, 00153 Rome, Italy.
  slot:
    index: 2
    item: Cavani A
      type: Person
      first name: Andrea
      last name: Cavani
      member of: National Institute for Health, Migration and Poverty INMP/NIHMP, Via di S.Gallicano, 25, 00153 Rome, Italy.
  slot:
    index: 3
    item: Cattani C
      type: Person
      first name: Caterina
      last name: Cattani
      member of: National Institute for Health, Migration and Poverty INMP/NIHMP, Via di S.Gallicano, 25, 00153 Rome, Italy.
  slot:
    index: 4
    item: Scopelliti F
      type: Person
      first name: Fernanda
      last name: Scopelliti
      member of: National Institute for Health, Migration and Poverty INMP/NIHMP, Via di S.Gallicano, 25, 00153 Rome, Italy.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D014945Q000502
has primary subject term: D012867Q000473
has subject term: D006801
has subject term: D007249Q000473
has subject term: D016207
has subject term: D007107Q000378
source: Cells. 2024-04-04;13(7):.
volume: 13

Silencing the Mitochondrial Gatekeeper VDAC1 as a Potential Treatment for Bladder Cancer.
pmid: 38607066
abstract: The strategy for treating bladder cancer (BC) depends on whether there is muscle invasion or not, with the latter mostly treated with intravesical therapy, such as with bacillus Calmette-Guérin (BCG). However, BCG treatment is unsuccessful in 70% of patients, who are then subjected to radical cystectomy. Although immune-checkpoint inhibitors have been approved as a second-line therapy for a subset of BC patients, these have failed to meet primary endpoints in clinical trials. Thus, it is crucial to find a new treatment. The mitochondrial gatekeeper protein, the voltage-dependent anion channel 1 (VDAC1), mediates metabolic crosstalk between the mitochondria and cytosol and is involved in apoptosis. It is overexpressed in many cancer types, as shown here for BC, pointing to its significance in high-energy-demanding cancer cells. The BC cell lines UM-UC3 and HTB-5 express high VDAC1 levels compared to other cancer cell lines. VDAC1 silencing in these cells using siRNA that recognizes both human and mouse VDAC1 (si-m/hVDAC1-B) reduces cell viability, mitochondria membrane potential, and cellular ATP levels. Here, we used two BC mouse models: subcutaneous UM-UC3 cells and chemically induced BC using the carcinogen N-Butyl-N-(4-hydroxybutyl) nitrosamine (BBN). Subcutaneous UM-UC3-derived tumors treated with si-m/hVDAC1 showed inhibited tumor growth and reprogrammed metabolism, as reflected in the reduced expression of metabolism-related proteins, including Glut1, hexokinase, citrate synthase, complex-IV, and ATP synthase, suggesting reduced metabolic activity. Furthermore, si-m/hVDAC1-B reduced the expression levels of cancer-stem-cell-related proteins (cytokeratin-14, ALDH1a), modifying the tumor microenvironment, including decreased angiogenesis, extracellular matrix, tumor-associated macrophages, and inhibited epithelial-mesenchymal transition. The BBN-induced BC mouse model showed a clear carcinoma, with damaged bladder morphology and muscle-invasive tumors. Treatment[cell cut: 2341 characters, first 2000 kept]
has PII: cells13070627
doi: 10.3390/cells13070627
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Alhozeel B
      type: Person
      first name: Belal
      last name: Alhozeel
      member of: Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  slot:
    index: 2
    item: Pandey SK
      type: Person
      first name: Swaroop Kumar
      last name: Pandey
      member of: Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  slot:
    index: 3
    item: Shteinfer-Kuzmine A
      type: Person
      first name: Anna
      last name: Shteinfer-Kuzmine
      member of: National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  slot:
    index: 4
    item: Santhanam M
      type: Person
      first name: Manikandan
      last name: Santhanam
      member of: Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  slot:
    index: 5
    item: Shoshan-Barmatz V
      type: Person
      first name: Varda
      last name: Shoshan-Barmatz
      member of: Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D050995Q000378
has primary subject term: D001749Q000473
has subject term: D006801
has subject term: D000818
has subject term: D051379
has subject term: D001500
has subject term: D008928Q000378
has subject term: D000255Q000378
has subject term: D059016
source: Cells. 2024-04-04;13(7):.
volume: 13

The Emerging Role of LPA as an Oncometabolite.
pmid: 38607068
abstract: Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that are regulated in both an autocrine and paracrine manner. It can be found both extra- and intracellularly, where it interacts with different receptors to activate signalling pathways that regulate a plethora of cellular processes, including mitosis, proliferation and migration. LPA metabolism is complex, and its biosynthesis and catabolism are under tight control to ensure proper LPA levels in the body. In cancer patient specimens, LPA levels are frequently higher compared to those of healthy individuals and often correlate with poor responses and more aggressive disease. Accordingly, LPA, through promoting cancer cell migration and invasion, enhances the metastasis and dissemination of tumour cells. In this review, we summarise the role of LPA in the regulation of critical aspects of tumour biology and further discuss the available pre-clinical and clinical evidence regarding the feasibility and efficacy of targeting LPA metabolism for effective anticancer therapy.
has PII: cells13070629
doi: 10.3390/cells13070629
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Karalis T
      type: Person
      first name: Theodoros
      last name: Karalis
      member of: Signalling and Cancer Metabolism Laboratory, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
  slot:
    index: 2
    item: Poulogiannis G
      type: Person
      first name: George
      last name: Poulogiannis
      member of: Signalling and Cancer Metabolism Laboratory, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
created: 2024-4-12T12:42
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D009369
has subject term: D006801
has subject term: D015398Q000502
has subject term: D002465
has subject term: D008246Q000378
source: Cells. 2024-04-04;13(7):.
volume: 13

Ex Pluribus Unum: The CD4 T Cell Response against Influenza A Virus.
pmid: 38607077
abstract: Current Influenza A virus (IAV) vaccines, which primarily aim to generate neutralizing antibodies against the major surface proteins of specific IAV strains predicted to circulate during the annual 'flu' season, are suboptimal and are characterized by relatively low annual vaccine efficacy. One approach to improve protection is for vaccines to also target the priming of virus-specific T cells that can protect against IAV even in the absence of preexisting neutralizing antibodies. CD4 T cells represent a particularly attractive target as they help to promote responses by other innate and adaptive lymphocyte populations and can also directly mediate potent effector functions. Studies in murine models of IAV infection have been instrumental in moving this goal forward. Here, we will review these findings, focusing on distinct subsets of CD4 T cell effectors that have been shown to impact outcomes. This body of work suggests that a major challenge for next-generation vaccines will be to prime a CD4 T cell population with the same spectrum of functional diversity generated by IAV infection. This goal is encapsulated well by the motto 'ex pluribus unum': that an optimal CD4 T cell response comprises many individual specialized subsets responding together.
has PII: cells13070639
doi: 10.3390/cells13070639
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Finn CM
      type: Person
      first name: Caroline M
      last name: Finn
      member of: Immunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
  slot:
    index: 2
    item: McKinstry KK
      type: Person
      first name: K Kai
      last name: McKinstry
      member of: Immunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D009980
has primary subject term: D007251
has primary subject term: D007252Q000276
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D057134
has subject term: D015496
has subject term: D014612
source: Cells. 2024-04-05;13(7):.
volume: 13

A Custom Panel for Profiling Microglia Gene Expression.
pmid: 38607069
abstract: Despite being immune cells of the central nervous system (CNS), microglia contribute to CNS development, maturation, and homeostasis, and microglia dysfunction has been implicated in several neurological disorders. Recent advancements in single-cell studies have uncovered unique microglia-specific gene expression. However, there is a need for a simple yet elegant multiplexed approach to quantifying microglia gene expression. To address this, we have designed a NanoString nCounter technology-based murine microglia-specific custom codeset comprising 178 genes. We analyzed RNA extracted from ex vivo adult mouse microglia, primary mouse microglia, the BV2 microglia cell line, and mouse bone marrow monocytes using our custom panel. Our findings reveal a pattern where homeostatic genes exhibit heightened expression in adult microglia, followed by primary cells, and are absent in BV2 cells, while reactive markers are elevated in primary microglia and BV2 cells. Analysis of publicly available data sets for the genes present in the panel revealed that the panel could reliably reflect the changes in microglia gene expression in response to various factors. These findings highlight that the microglia panel used offers a swift and cost-effective means to assess microglial cells and can be used to study them in varying contexts, ranging from normal homeostasis to disease models.
has PII: cells13070630
doi: 10.3390/cells13070630
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Potru PS
      type: Person
      first name: Phani Sankar
      last name: Potru
      member of: Bielefeld University, Medical School OWL, Anatomy and Cell Biology, 33615 Bielefeld, Germany.
  slot:
    index: 2
    item: Vidovic N
      type: Person
      first name: Natascha
      last name: Vidovic
      member of: Bielefeld University, Medical School OWL, Anatomy and Cell Biology, 33615 Bielefeld, Germany.
  slot:
    index: 3
    item: Wiemann S
      type: Person
      first name: Susanne
      last name: Wiemann
      member of: Bielefeld University, Medical School OWL, Anatomy and Cell Biology, 33615 Bielefeld, Germany.
  slot:
    index: 4
    item: Russ T
      type: Person
      first name: Tamara
      last name: Russ
      member of: Bielefeld University, Medical School OWL, Anatomy and Cell Biology, 33615 Bielefeld, Germany.
  slot:
    index: 5
    item: Trautmann M
      type: Person
      first name: Marcel
      last name: Trautmann
      member of: Gerhard-Domagk-Institute of Pathology, Münster University Hospital, 48149 Münster, Germany.
  slot:
    index: 6
    item: Spittau B
      type: Person
      first name: Björn
      last name: Spittau
      member of: Bielefeld University, Medical School OWL, Anatomy and Cell Biology, 33615 Bielefeld, Germany.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D017628Q000378
has subject term: D051379
has subject term: D000818
has subject term: D002460
has subject term: D015870
source: Cells. 2024-04-04;13(7):.
volume: 13

Peritumor Mucosa in Advanced Laryngeal Carcinoma Exhibits an Aberrant Proangiogenic Signature Distinctive from the Expression Pattern in Adjacent Tumor Tissue.
pmid: 38607072
abstract: The field cancerization theory is an important paradigm in head and neck carcinoma as its oncological repercussions affect treatment outcomes in diverse ways. The aim of this study is to assess the possible interconnection between peritumor mucosa and the process of tumor neoangiogenesis. Sixty patients with advanced laryngeal carcinoma were enrolled in this study. The majority of patients express a canonical HIF-upregulated proangiogenic signature with almost complete predominancy of HIF-1α overexpression and normal expression levels of the HIF-2α isoform. Remarkably, more than 60% of the whole cohort also exhibited an HIF-upregulated proangiogenic signature in the peritumoral benign mucosa. Additionally, the latter subgroup had a distinctly shifted phenotype towards HIF-2α upregulation compared to the one in tumor tissue, i.e., a tendency towards an HIF switch is observed in contrast to the dominated by HIF-1α tumor phenotype. ETS-1 displays stable and identical significant overexpression in both the proangiogenic phenotypes present in tumor and peritumoral mucosa. In the current study, we report for the first time the existence of an abnormal proangiogenic expression profile present in the peritumoral mucosa in advanced laryngeal carcinoma when compared to paired distant laryngeal mucosa. Moreover, we describe a specific phenotype of this proangiogenic signature that is significantly different from the one present in tumor tissue as we delineate both phenotypes, quantitively and qualitatively. This finding is cancer heterogeneity, per se, which extends beyond the classical borders of the malignancy, and it is proof of a strong interconnection between field cancerization and one of the classical hallmarks of cancer-the process of tumor neoangiogenesis.
has PII: cells13070633
doi: 10.3390/cells13070633
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Kyurkchiyan SG
      type: Person
      first name: Silva G
      last name: Kyurkchiyan
      member of: Molecular Medicine Center, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 2
    item: Stancheva G
      type: Person
      first name: Gergana
      last name: Stancheva
      member of: Molecular Medicine Center, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 3
    item: Petkova V
      type: Person
      first name: Veronika
      last name: Petkova
      member of: Molecular Medicine Center, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 4
    item: Panova S
      type: Person
      first name: Stiliana
      last name: Panova
      member of: Molecular Medicine Center, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 5
    item: Dobriyanova V
      type: Person
      first name: Venera
      last name: Dobriyanova
      member of: Department of ENT, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 6
    item: Stancheva I
      type: Person
      first name: Iglika
      last name: Stancheva
      member of: Department of ENT, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 7
    item: Marinov V
      type: Person
      first name: Venelin
      last name: Marinov
      member of: Department of ENT, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 8
    item: Zahariev Z
      type: Person
      first name: Zahari
      last name: Zahariev
      member of: Department of ENT, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 9
    item: Kaneva RP
      type: Person
      first name: Radka P
      last name: Kaneva
      member of: Molecular Medicine Center, Medical University-Sofia, 1463 Sofia, Bulgaria.
  slot:
    index: 10
    item: Popov TM
      type: Person
      first name: Todor M
      last name: Popov
      member of: Department of ENT, Medical University-Sofia, 1463 Sofia, Bulgaria.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D007822Q000235
has primary subject term: D002277
has subject term: D006801
has subject term: D009389Q000235
has subject term: D009092
has subject term: D051792Q000378
source: Cells. 2024-04-05;13(7):.
volume: 13

Leflunomide Treatment Does Not Protect Neural Cells following Oxygen-Glucose Deprivation (OGD) In Vitro.
pmid: 38607070
abstract: Neonatal hypoxia-ischemia (HI) affects 2-3 per 1000 live births in developed countries and up to 26 per 1000 live births in developing countries. It is estimated that of the 750,000 infants experiencing a hypoxic-ischemic event during birth per year, more than 400,000 will be severely affected. As treatment options are limited, rapidly identifying new therapeutic avenues is critical, and repurposing drugs already in clinical use offers a fast-track route to clinic. One emerging avenue for therapeutic intervention in neonatal HI is to target mitochondrial dysfunction, which occurs early in the development of brain injury. Mitochondrial dynamics are particularly affected, with mitochondrial fragmentation occurring at the expense of the pro-fusion protein Optic Atrophy (OPA)1. OPA1, together with mitofusins (MFN)1/2, are required for membrane fusion, and therefore, protecting their function may also safeguard mitochondrial dynamics. Leflunomide, an FDA-approved immunosuppressant, was recently identified as an activator of MFN2 with partial effects on OPA1 expression. We, therefore, treated C17.2 cells with Leflunomide before or after oxygen-glucose deprivation, an in vitro mimic of HI, to determine its efficacy as a neuroprotection and inhibitor of mitochondrial dysfunction. Leflunomide increased baseline OPA1 but not MFN2 expression in C17.2 cells. However, Leflunomide was unable to promote cell survival following OGD. Equally, there was no obvious effect on mitochondrial morphology or bioenergetics. These data align with studies suggesting that the tissue and mitochondrial protein profile of the target cell/tissue are critical for taking advantage of the therapeutic actions of Leflunomide.
has PII: cells13070631
doi: 10.3390/cells13070631
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Curel CJM
      type: Person
      first name: Claire J M
      last name: Curel
      member of: Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK.
  slot:
    index: 2
    item: Nobeli I
      type: Person
      first name: Irene
      last name: Nobeli
      member of: School of Natural Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, London WC1E 7HX, UK.
  slot:
    index: 3
    item: Thornton C
      type: Person
      first name: Claire
      last name: Thornton
      member of: Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D010100Q000378
has primary subject term: D028361
has subject term: D007231
has subject term: D006801
has subject term: D005947Q000378
has subject term: D000077339Q000494
has subject term: D002478
source: Cells. 2024-04-04;13(7):.
volume: 13

A Novel Approach for Glioblastoma Treatment by Combining Apoptosis Inducers (TMZ, MTX, and Cytarabine) with E.V.A. (Eltanexor, Venetoclax, and A1210477) Inhibiting XPO1, Bcl-2, and Mcl-1.
pmid: 38607071
abstract: Adjuvant treatment for Glioblastoma Grade 4 with Temozolomide (TMZ) inevitably fails due to therapeutic resistance, necessitating new approaches. Apoptosis induction in GB cells is inefficient, due to an excess of anti-apoptotic XPO1/Bcl-2-family proteins. We assessed TMZ, Methotrexate (MTX), and Cytarabine (Ara-C) (apoptosis inducers) combined with XPO1/Bcl-2/Mcl-1-inhibitors (apoptosis rescue) in GB cell lines and primary GB stem-like cells (GSCs). Using CellTiter-Glo® and Caspase-3 activity assays, we generated dose-response curves and analyzed the gene and protein regulation of anti-apoptotic proteins via PCR and Western blots. Optimal drug combinations were examined for their impact on the cell cycle and apoptosis induction via FACS analysis, paralleled by the assessment of potential toxicity in healthy mouse brain slices. Ara-C and MTX proved to be 150- to 10,000-fold more potent in inducing apoptosis than TMZ. In response to inhibitors Eltanexor (XPO1; E), Venetoclax (Bcl-2; V), and A1210477 (Mcl-1; A), genes encoding for the corresponding proteins were upregulated in a compensatory manner. TMZ, MTX, and Ara-C combined with E, V, and A evidenced highly lethal effects when combined. As no significant cell death induction in mouse brain slices was observed, we conclude that this drug combination is effective in vitro and expected to have low side effects in vivo.
has PII: cells13070632
doi: 10.3390/cells13070632
creator: OrderedList
  length: 19
  slot:
    index: 1
    item: Zhao K
      type: Person
      first name: Kai
      last name: Zhao
      member of: Department of Neurosurgery, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.Department of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 2
    item: Braun M
      type: Person
      first name: Madita
      last name: Braun
      member of: Department of Neurosurgery, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.Department of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 3
    item: Meyer L
      type: Person
      first name: Leonie
      last name: Meyer
      member of: Department of Neurosurgery, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.Department of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 4
    item: Otte K
      type: Person
      first name: Katharina
      last name: Otte
      member of: Department of Neurosurgery, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.Department of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 5
    item: Raifer H
      type: Person
      first name: Hartmann
      last name: Raifer
      member of: FACS Core Facility, Philipps University Marburg, Hans-Meerwein-Straße 3, 35043 Marburg, Germany.
  slot:
    index: 6
    item: Helmprobst F
      type: Person
      first name: Frederik
      last name: Helmprobst
      member of: Department of Neuropathology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 7
    item: Möschl V
      type: Person
      first name: Vincent
      last name: Möschl
      member of: Department of Neuropathology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 8
    item: Pagenstecher A
      type: Person
      first name: Axel
      last name: Pagenstecher
      member of: Department of Neuropathology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  slot:
    index: 9
    item: Urban H
      type: Person
      first name: Hans
      last name: Urban
      member of: University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.Dr. Senckenberg Institute of Neurooncology, Goethe-University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.
  slot:
    index: 10
    item: Ronellenfitsch MW
      type: Person
      first name: Michael W
      last name: Ronellenfitsch
      member of: University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.Dr. Senckenberg Institute of Neurooncology, Goethe-University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.
  slot:
    index: 11
    item: Steinbach JP
      type: Person
      first name: Joachim P
      last name: Steinbach
      member of: University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.Dr. Senckenberg Institute of Neurooncology, Goethe-University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany.
  slot:
    index: 12
    item: Pesek J
      type: Person
      first name: Jelena
      last name: Pesek
      member of: Medical Mass Spectrometry Core Facility, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 13
    item: Watzer B
      type: Person
      first name: Bernhard
      last name: Watzer
      member of: Medical Mass Spectrometry Core Facility, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 14
    item: Nockher WA
      type: Person
      first name: Wolfgang A
      last name: Nockher
      member of: Medical Mass Spectrometry Core Facility, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 15
    item: Taudte RV
      type: Person
      first name: R Verena
      last name: Taudte
      member of: Medical Mass Spectrometry Core Facility, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.
  slot:
    index: 16
    item: Neubauer A
      type: Person
      first name: Andreas
      last name: Neubauer
      member of: Department of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  slot:
    index: 17
    item: Nimsky C
      type: Person
      first name: Christopher
      last name: Nimsky
      member of: Department of Neurosurgery, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  slot:
    index: 18
    item: Bartsch JW
      type: Person
      first name: Jörg W
      last name: Bartsch
      member of: Department of Neurosurgery, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
  slot:
    index: 19
    item: Rusch T
      type: Person
      first name: Tillmann
      last name: Rusch
      member of: Department of Hematology, Oncology & Immunology, Philipps University Marburg, Baldingerstraße 1, 35043 Marburg, Germany.University Cancer Center (UCT) Frankfurt-Marburg, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D005909Q000188Q000378
has primary subject term: D000970Q000494
has primary subject term: D000577
has primary subject term: D011743
has primary subject term: D013449
has primary subject term: D019086
has subject term: D000818
has subject term: D051379
has subject term: D000077204Q000494
has subject term: D008727Q000494Q000627
has subject term: D003561Q000494Q000627
has subject term: D018906Q000494
has subject term: D045744
has subject term: D017209
source: Cells. 2024-04-04;13(7):.
volume: 13

Generation of Artificial Blastoids Combining miR-200-Mediated Reprogramming and Mechanical Cues.
pmid: 38607067
abstract: In vitro-generated blastocyst-like structures are of great importance since they recapitulate specific features or processes of early embryogenesis, thus avoiding ethical concerns as well as increasing scalability and accessibility compared to the use of natural embryos. Here, we combine cell reprogramming and mechanical stimuli to create 3D spherical aggregates that are phenotypically similar to those of natural embryos. Specifically, dermal fibroblasts are reprogrammed, exploiting the miR-200 family property to induce a high plasticity state in somatic cells. Subsequently, miR-200-reprogrammed cells are either driven towards the trophectoderm (TR) lineage using an ad hoc induction protocol or encapsulated into polytetrafluoroethylene micro-bioreactors to maintain and promote pluripotency, generating inner cell mass (ICM)-like spheroids. The obtained TR-like cells and ICM-like spheroids are then co-cultured in the same micro-bioreactor and, subsequently, transferred to microwells to encourage blastoid formation. Notably, the above protocol was applied to fibroblasts obtained from young as well as aged donors, with results that highlighted miR-200's ability to successfully reprogram young and aged cells with comparable blastoid rates, regardless of the donor's cell age. Overall, the approach here described represents a novel strategy for the creation of artificial blastoids to be used in the field of assisted reproduction technologies for the study of peri- and early post-implantation mechanisms.
has PII: cells13070628
doi: 10.3390/cells13070628
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pennarossa G
      type: Person
      first name: Georgia
      last name: Pennarossa
      member of: Laboratory of Biomedical Embryology and Tissue Engineering, Department of Health, Animal Science and Food Safety and Center for Stem Cell Research, Università degli Studi di Milano, 20133 Milan, Italy.
  slot:
    index: 2
    item: Arcuri S
      type: Person
      first name: Sharon
      last name: Arcuri
      member of: Laboratory of Biomedical Embryology and Tissue Engineering, Department of Health, Animal Science and Food Safety and Center for Stem Cell Research, Università degli Studi di Milano, 20133 Milan, Italy.
  slot:
    index: 3
    item: Gandolfi F
      type: Person
      first name: Fulvio
      last name: Gandolfi
      member of: Department of Agricultural and Environmental Sciences-Production, Landscape, Agroenergy, Università degli Studi di Milano, 20133 Milan, Italy.
  slot:
    index: 4
    item: Brevini TAL
      type: Person
      first name: Tiziana A L
      last name: Brevini
      member of: Laboratory of Biomedical Embryology and Tissue Engineering, Department of Health, Animal Science and Food Safety and Center for Stem Cell Research, Università degli Studi di Milano, 20133 Milan, Italy.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-04
dp: 2024 04 04
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D003463
has primary subject term: D035683Q000235
has subject term: D001755
has subject term: D065150
has subject term: D010064
source: Cells. 2024-04-04;13(7):.
volume: 13

Therapeutic effect of ZnO NPs-polyhexanide-hydrogel on Staphylococcus aureus-induced skin wound infection in mice.
pmid: 38613795
abstract: Nanometer zinc oxide (ZnONPs) offers strong antibacterial, wound healing, hemostatic benefits, and UV protection. Additionally, poly(hexamethylene biguanide)hydrochloride (PHMB) is an environmentally friendly polymer with strong bactericidal properties. However, the synergistic effect of the combination of ZnONPs and PHMB has not been previously explored. The purpose of this study is to explore the synergies of ZnONPs and PHMB and the healing efficacy of ZnO NPs-PHMB-hydrogel on skin wounds in mice infected with Staphylococcus aureus. Therefore, the mice were subjected to skin trauma to create a wound model and were subsequently infected with S. aureus, and then divided into various experimental groups. The repair effect was evaluated by assessing the healing rate, as well as measuring the levels of TNF-α, IL-2, EGF, and TGF-β1 contents in the tissue. On the 4th and 9th days post-modeling, the Z-P group exhibited notably higher healing rates compared to the control group. However, on the 15th day, both the Z-P and AC groups achieved healing rates exceeding 99%. ZnO NPs-PHMB-hydrogel promoted the formation of a fully restored epithelium, increased new hair follicles and sebaceous glands beneath the epidermis, and markedly reduced inflammatory cell infiltration, which was markedly distinct from the control group. On the 7th day, the Z-P group exhibited significantly higher levels of EGF and TGF-β1, along with a considerable reduction in the TNF-α levels as compared with the control group. These results affirmed that ZnO NPs-PHMB-hydrogel effectively inhibits S. aureus infection and accelerates skin wound healing.
doi: 10.1080/09205063.2024.2340819
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Zhu J
      type: Person
      first name: Junhe
      last name: Zhu
      member of: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 2
    item: Li Y
      type: Person
      first name: Yuxin
      last name: Li
      member of: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 3
    item: Tang Y
      type: Person
      first name: Yixin
      last name: Tang
      member of: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 4
    item: Fan Y
      type: Person
      first name: Yike
      last name: Fan
      member of: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 5
    item: Dai S
      type: Person
      first name: Shiyi
      last name: Dai
      member of: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 6
    item: Abbas A
      type: Person
      first name: Awn
      last name: Abbas
      member of: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 7
    item: Xu F
      type: Person
      first name: Funeng
      last name: Xu
      member of: Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 8
    item: Wang X
      type: Person
      first name: Xianxiang
      last name: Wang
      member of: Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 9
    item: Zhang W
      type: Person
      first name: Wei
      last name: Zhang
      member of: Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  slot:
    index: 10
    item: Zheng Y
      type: Person
      first name: Yilei
      last name: Zheng
      member of: Center for Veterinary Sciences, Zhejiang University, Hangzhou, China.
  slot:
    index: 11
    item: Shu G
      type: Person
      first name: Gang
      last name: Shu
      member of: Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
created: 2024-4-13T20:44
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-13T12:53
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1571
ending page: 1583
has place of publication: England
has primary subject term: D015034Q000737Q000494
has primary subject term: D001645Q000494Q000737
has primary subject term: D013211Q000187
has primary subject term: D014945Q000187
has primary subject term: D020100Q000737Q000494
has primary subject term: D000900Q000494Q000737
has subject term: D000818
has subject term: D051379
has subject term: D012867Q000187Q000382Q000473
has subject term: D013203Q000188
has subject term: D014946Q000188Q000382
has subject term: D008297
has subject term: D013207Q000188
source: J Biomater Sci Polym Ed. 2024-07;35(10):1571-1583.
volume: 35

Upregulation of the Renin-Angiotensin System Is Associated with Patient Survival and the Tumour Microenvironment in Glioblastoma.
pmid: 38607073
abstract: Glioblastoma is a highly aggressive disease with poor survival outcomes. An emerging body of literature links the role of the renin-angiotensin system (RAS), well-known for its function in the cardiovascular system, to the progression of cancers. We studied the expression of RAS-related genes (ATP6AP2, AGTR1, AGTR2, ACE, AGT, and REN) in The Cancer Genome Atlas (TCGA) glioblastoma cohort, their relationship to patient survival, and association with tumour microenvironment pathways. The expression of RAS genes was then examined in 12 patient-derived glioblastoma cell lines treated with chemoradiation. In cases of glioblastoma within the TCGA, ATP6AP2, AGTR1, ACE, and AGT had consistent expressions across samples, while AGTR2 and REN were lowly expressed. High expression of AGTR1 was independently associated with lower progression-free survival (PFS) (p = 0.01) and had a non-significant trend for overall survival (OS) after multivariate analysis (p = 0.095). The combined expression of RAS receptors (ATP6AP2, AGTR1, and AGTR2) was positively associated with gene pathways involved in hypoxia, microvasculature, stem cell plasticity, and the molecular characterisation of glioblastoma subtypes. In patient-derived glioblastoma cell lines, ATP6AP2 and AGTR1 were upregulated after chemoradiotherapy and correlated with an increase in HIF1A expression. This data suggests the RAS is correlated with changes in the tumour microenvironment and associated with glioblastoma survival outcomes.
has PII: cells13070634
doi: 10.3390/cells13070634
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Lozinski M
      type: Person
      first name: Mathew
      last name: Lozinski
      member of: School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.Mark Hughes Foundation Centre for Brain Cancer Research, University of Newcastle, Callaghan, NSW 2308, Australia.Drug Repurposing and Medicines Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  slot:
    index: 2
    item: Lumbers ER
      type: Person
      first name: Eugenie R
      last name: Lumbers
      member of: School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  slot:
    index: 3
    item: Bowden NA
      type: Person
      first name: Nikola A
      last name: Bowden
      member of: School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.Drug Repurposing and Medicines Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  slot:
    index: 4
    item: Martin JH
      type: Person
      first name: Jennifer H
      last name: Martin
      member of: School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.Drug Repurposing and Medicines Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  slot:
    index: 5
    item: Fay MF
      type: Person
      first name: Michael F
      last name: Fay
      member of: School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.Mark Hughes Foundation Centre for Brain Cancer Research, University of Newcastle, Callaghan, NSW 2308, Australia.Drug Repurposing and Medicines Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.GenesisCare, Gateshead, NSW 2290, Australia.
  slot:
    index: 6
    item: Pringle KG
      type: Person
      first name: Kirsty G
      last name: Pringle
      member of: School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
  slot:
    index: 7
    item: Tooney PA
      type: Person
      first name: Paul A
      last name: Tooney
      member of: Mark Hughes Foundation Centre for Brain Cancer Research, University of Newcastle, Callaghan, NSW 2308, Australia.Drug Repurposing and Medicines Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW 2308, Australia.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D012084Q000235
has primary subject term: D005909Q000235
has subject term: D006801
has subject term: D015854Q000235
has subject term: D059016
has subject term: D011956Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000093342
source: Cells. 2024-04-05;13(7):.
volume: 13

GDF-15 Suppresses Puromycin Aminonucleoside-Induced Podocyte Injury by Reducing Endoplasmic Reticulum Stress and Glomerular Inflammation.
pmid: 38607075
abstract: GDF15, also known as MIC1, is a member of the TGF-beta superfamily. Previous studies reported elevated serum levels of GDF15 in patients with kidney disorder, and its association with kidney disease progression, while other studies identified GDF15 to have protective effects. To investigate the potential protective role of GDF15 on podocytes, we first performed in vitro studies using a Gdf15-deficient podocyte cell line. The lack of GDF15 intensified puromycin aminonucleoside (PAN)-triggered endoplasmic reticulum stress and induced cell death in cultivated podocytes. This was evidenced by elevated expressions of Xbp1 and ER-associated chaperones, alongside AnnexinV/PI staining and LDH release. Additionally, we subjected mice to nephrotoxic PAN treatment. Our observations revealed a noteworthy increase in both GDF15 expression and secretion subsequent to PAN administration. Gdf15 knockout mice displayed a moderate loss of WT1+ cells (podocytes) in the glomeruli compared to wild-type controls. However, this finding could not be substantiated through digital evaluation. The parameters of kidney function, including serum BUN, creatinine, and albumin-creatinine ratio (ACR), were increased in Gdf15 knockout mice as compared to wild-type mice upon PAN treatment. This was associated with an increase in the number of glomerular macrophages, neutrophils, inflammatory cytokines, and chemokines in Gdf15-deficient mice. In summary, our findings unveil a novel renoprotective effect of GDF15 during kidney injury and inflammation by promoting podocyte survival and regulating endoplasmic reticulum stress in podocytes, and, subsequently, the infiltration of inflammatory cells via paracrine effects on surrounding glomerular cells.
has PII: cells13070637
doi: 10.3390/cells13070637
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: von Rauchhaupt E
      type: Person
      first name: Ekaterina
      last name: von Rauchhaupt
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 2
    item: Klaus M
      type: Person
      first name: Martin
      last name: Klaus
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 3
    item: Ribeiro A
      type: Person
      first name: Andrea
      last name: Ribeiro
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.Klinikum Rechts der Isar, Department of Nephrology, Technical University Munich, 81675 Munich, Germany.
  slot:
    index: 4
    item: Honarpisheh M
      type: Person
      first name: Mohsen
      last name: Honarpisheh
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 5
    item: Li C
      type: Person
      first name: Chenyu
      last name: Li
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 6
    item: Liu M
      type: Person
      first name: Min
      last name: Liu
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 7
    item: Köhler P
      type: Person
      first name: Paulina
      last name: Köhler
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 8
    item: Adamowicz K
      type: Person
      first name: Karina
      last name: Adamowicz
      member of: Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University, 30-387 Krakow, Poland.
  slot:
    index: 9
    item: Schmaderer C
      type: Person
      first name: Christoph
      last name: Schmaderer
      member of: Klinikum Rechts der Isar, Department of Nephrology, Technical University Munich, 81675 Munich, Germany.
  slot:
    index: 10
    item: Lindenmeyer M
      type: Person
      first name: Maja
      last name: Lindenmeyer
      member of: III Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
  slot:
    index: 11
    item: Steiger S
      type: Person
      first name: Stefanie
      last name: Steiger
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 12
    item: Anders HJ
      type: Person
      first name: Hans-Joachim
      last name: Anders
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  slot:
    index: 13
    item: Lech M
      type: Person
      first name: Maciej
      last name: Lech
      member of: Department of Medicine IV, Renal Division, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D050199Q000378
has primary subject term: D007674Q000378
has subject term: D006801
has subject term: D051379
has subject term: D000818
has subject term: D011692Q000009Q000378
has subject term: D055436Q000235Q000378
has subject term: D003404Q000378
has subject term: D007249Q000378
has subject term: D018345
source: Cells. 2024-04-05;13(7):.
volume: 13

Cell Membrane Fragment-Wrapped Parenteral Nanoemulsions: A New Drug Delivery Tool to Target Gliomas.
pmid: 38607080
abstract: Poor prognosis in high-grade gliomas is mainly due to fatal relapse after surgical resection in the absence of efficient chemotherapy, which is severely hampered by the blood-brain barrier. However, the leaky blood-brain-tumour barrier forms upon tumour growth and vascularization, allowing targeted nanocarrier-mediated drug delivery. The homotypic targeting ability of cell-membrane fragments obtained from cancer cells means that these fragments can be exploited to this aim. In this experimental work, injectable nanoemulsions, which have a long history of safe clinic usage, have been wrapped in glioma-cell membrane fragments via co-extrusion to give targeted, homogeneously sized, sterile formulations. These systems were then loaded with three different chemotherapeutics, in the form of hydrophobic ion pairs that can be released into the target site thanks to interactions with physiological components. The numerous assays performed in two-dimensional (2D) and three-dimensional (3D) cell models demonstrate that the proposed approach is a versatile drug-delivery platform with chemo-tactic properties towards glioma cells, with adhesive interactions between the target cell and the cell membrane fragments most likely being responsible for the effect. This approach's promising translational perspectives towards personalized nanomedicine mean that further in vivo studies are foreseen for the future.
has PII: cells13070641
doi: 10.3390/cells13070641
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Dianzani C
      type: Person
      first name: Chiara
      last name: Dianzani
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 2
    item: Bozza A
      type: Person
      first name: Annalisa
      last name: Bozza
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 3
    item: Bordano V
      type: Person
      first name: Valentina
      last name: Bordano
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 4
    item: Cangemi L
      type: Person
      first name: Luigi
      last name: Cangemi
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 5
    item: Ferraris C
      type: Person
      first name: Chiara
      last name: Ferraris
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 6
    item: Foglietta F
      type: Person
      first name: Federica
      last name: Foglietta
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 7
    item: Monge C
      type: Person
      first name: Chiara
      last name: Monge
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 8
    item: Gallicchio M
      type: Person
      first name: Margherita
      last name: Gallicchio
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 9
    item: Pizzimenti S
      type: Person
      first name: Stefania
      last name: Pizzimenti
      member of: Department of Clinical and Biological Sciences, University of Turin, Corso Raffaello 30, 10124 Turin, Italy.
  slot:
    index: 10
    item: Marini E
      type: Person
      first name: Elisabetta
      last name: Marini
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 11
    item: Muntoni E
      type: Person
      first name: Elisabetta
      last name: Muntoni
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.
  slot:
    index: 12
    item: Valsania MC
      type: Person
      first name: Maria Carmen
      last name: Valsania
      member of: Department of Chemistry, University of Turin, Via Quarello 15/a, 10135 Turin, Italy.Nanostructured Interfaces and Surfaces (NIS) Interdepartmental Centre, University of Turin, 10124 Turin, Italy.
  slot:
    index: 13
    item: Battaglia L
      type: Person
      first name: Luigi
      last name: Battaglia
      member of: Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10124 Turin, Italy.Nanostructured Interfaces and Surfaces (NIS) Interdepartmental Centre, University of Turin, 10124 Turin, Italy.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-06
dp: 2024 04 06
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D009364Q000378
has primary subject term: D005910Q000188Q000378
has subject term: D006801
has subject term: D016503Q000379
has subject term: D001812Q000378
has subject term: D002462
source: Cells. 2024-04-06;13(7):.
volume: 13

Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced Early Activation of Autophagy in INS-1 Pancreatic β Cells.
pmid: 38607078
abstract: Insulin-producing pancreatic β cells play a crucial role in the regulation of glucose homeostasis, and their failure is a key event for diabetes development. Prolonged exposure to palmitate in the presence of elevated glucose levels, termed gluco-lipotoxicity, is known to induce β cell apoptosis. Autophagy has been proposed to be regulated by gluco-lipotoxicity in order to favor β cell survival. However, the role of palmitate metabolism in gluco-lipotoxcity-induced autophagy is presently unknown. We therefore treated INS-1 cells for 6 and 24 h with palmitate in the presence of low and high glucose concentrations and then monitored autophagy. Gluco-lipotoxicity induces accumulation of LC3-II levels in INS-1 at 6 h which returns to basal levels at 24 h. Using the RFP-GFP-LC3 probe, gluco-lipotoxicity increased both autophagosomes and autolysosmes structures, reflecting early stimulation of an autophagy flux. Triacsin C, a potent inhibitor of the long fatty acid acetyl-coA synthase, completely prevents LC3-II formation and recruitment to autophagosomes, suggesting that autophagic response requires palmitate metabolism. In contrast, etomoxir and bromo-palmitate, inhibitors of fatty acid mitochondrial β-oxidation, are unable to prevent gluco-lipotoxicity-induced LC3-II accumulation and recruitment to autophagosomes. Moreover, bromo-palmitate and etomoxir potentiate palmitate autophagic response. Even if gluco-lipotoxicity raised ceramide levels in INS-1 cells, ceramide synthase 4 overexpression does not potentiate LC3-II accumulation. Gluco-lipotoxicity also still stimulates an autophagic flux in the presence of an ER stress repressor. Finally, selective inhibition of sphingosine kinase 1 (SphK1) activity precludes gluco-lipotoxicity to induce LC3-II accumulation. Moreover, SphK1 overexpression potentiates autophagic flux induced by gluco-lipotxicity. Altogether, our results indicate that early activation of autophagy by gluco-lipotoxicity is mediated by SphK1, which pla[cell cut: 2032 characters, first 2000 kept]
has PII: cells13070636
doi: 10.3390/cells13070636
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Coant N
      type: Person
      first name: Nicolas
      last name: Coant
      member of: Unité BFA, Université Paris Cité, CNRS UMR 8251, 75006 Paris, France.Department of Pathology and Stony Brook Cancer Center, Stony Brook University Renaissance School of Medicine, Stony Brook, NY 11794, USA.
  slot:
    index: 2
    item: Rendja K
      type: Person
      first name: Karima
      last name: Rendja
      member of: Unité BFA, Université Paris Cité, CNRS UMR 8251, 75006 Paris, France.
  slot:
    index: 3
    item: Bellini L
      type: Person
      first name: Lara
      last name: Bellini
      member of: Unité BFA, Université Paris Cité, CNRS UMR 8251, 75006 Paris, France.
  slot:
    index: 4
    item: Flamment M
      type: Person
      first name: Mélissa
      last name: Flamment
      member of: Inserm, UMR-S 872, Centre de Recherche des Cordeliers, 75006 Paris, France.
  slot:
    index: 5
    item: Lherminier J
      type: Person
      first name: Jeannine
      last name: Lherminier
      member of: INRA, UMR1347 Agroécologie, ERL CNRS 6300, Plateforme DImaCell, Centre de Microscopie INRA/Université de Bourgogne, 21065 Dijon, France.
  slot:
    index: 6
    item: Portha B
      type: Person
      first name: Bernard
      last name: Portha
      member of: Unité BFA, Université Paris Cité, CNRS UMR 8251, 75006 Paris, France.
  slot:
    index: 7
    item: Codogno P
      type: Person
      first name: Patrice
      last name: Codogno
      member of: INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades, University Paris Descartes, 75006 Paris, France.
  slot:
    index: 8
    item: Le Stunff H
      type: Person
      first name: Hervé
      last name: Le Stunff
      member of: Unité BFA, Université Paris Cité, CNRS UMR 8251, 75006 Paris, France.CNRS UMR 9197, Institut des Neurosciences Paris-Saclay, Saclay, University Paris, 91400 Saclay, France.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D050417Q000378
has primary subject term: D017853Q000378
has subject term: D001343
has subject term: D004852
has subject term: D005947Q000378
has subject term: D010168Q000378
has subject term: D002460
has subject term: D000818
has subject term: D051381
source: Cells. 2024-04-05;13(7):.
volume: 13

ERβ Regulation of Indian Hedgehog Expression in the First Wave of Ovarian Follicles.
pmid: 38607081
abstract: Increased activation of ovarian primordial follicles in Erβ knockout (ErβKO) rats becomes evident as early as postnatal day 8.5. To identify the ERβ-regulated genes that may control ovarian primordial follicle activation, we analyzed the transcriptome profiles of ErβKO rat ovaries collected on postnatal days 4.5, 6.5, and 8.5. Compared to wildtype ovaries, ErβKO ovaries displayed dramatic downregulation of Indian hedgehog (Ihh) expression. IHH-regulated genes, including Hhip, Gli1, and Ptch1, were also downregulated in ErβKO ovaries. This was associated with a downregulation of steroidogenic enzymes Cyp11a1, Cyp19a1, and Hsd17b1. The expression of Ihh remained very low in ErβKO ovaries despite the high levels of Gdf9 and Bmp15, which are known upregulators of Ihh expression in the granulosa cells of activated ovarian follicles. Strikingly, the downregulation of the Ihh gene in ErβKO ovaries began to disappear on postnatal day 16.5 and recovered on postnatal day 21.5. In rat ovaries, the first wave of primordial follicles is rapidly activated after their formation, whereas the second wave of primordial follicles remains dormant in the ovarian cortex and slowly starts activating after postnatal day 12.5. We localized the expression of Ihh mRNA in postnatal day 8.5 wildtype rat ovaries but not in the age-matched ErβKO ovaries. In postnatal day 21.5 ErβKO rat ovaries, we detected Ihh mRNA mainly in the activated follicles in the ovaries' peripheral regions. Our findings indicate that the expression of Ihh in the granulosa cells of the activated first wave of ovarian follicles depends on ERβ.
has PII: cells13070644
doi: 10.3390/cells13070644
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Chakravarthi VP
      type: Person
      first name: V Praveen
      last name: Chakravarthi
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 2
    item: Dilower I
      type: Person
      first name: Iman
      last name: Dilower
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 3
    item: Ghosh S
      type: Person
      first name: Subhra
      last name: Ghosh
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 4
    item: Borosha S
      type: Person
      first name: Shaon
      last name: Borosha
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 5
    item: Mohamadi R
      type: Person
      first name: Ryan
      last name: Mohamadi
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 6
    item: Dahiya V
      type: Person
      first name: Vinesh
      last name: Dahiya
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 7
    item: Vo K
      type: Person
      first name: Kevin
      last name: Vo
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 8
    item: Lee EB
      type: Person
      first name: Eun B
      last name: Lee
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 9
    item: Ratri A
      type: Person
      first name: Anamika
      last name: Ratri
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 10
    item: Kumar V
      type: Person
      first name: Vishnu
      last name: Kumar
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 11
    item: Marsh CA
      type: Person
      first name: Courtney A
      last name: Marsh
      member of: Obstetrics and Gynecology, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 12
    item: Fields PE
      type: Person
      first name: Patrick E
      last name: Fields
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
  slot:
    index: 13
    item: Rumi MAK
      type: Person
      first name: M A Karim
      last name: Rumi
      member of: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
created: 2024-4-12T12:43
date last updated: 2025-01-17
issued: 2024-04-06
dp: 2024 04 06
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D047629Q000235Q000378
has primary subject term: D053823Q000235Q000378
has subject term: D000818
has subject term: D005260
has subject term: D051381
has subject term: D006080Q000378
has subject term: D010053Q000378
has subject term: D012333Q000378
source: Cells. 2024-04-06;13(7):.
volume: 13

Nanoquercetin and Extracellular Vesicles as Potential Anticancer Therapeutics in Hepatocellular Carcinoma.
pmid: 38607076
abstract: Despite world-class sophisticated technologies, robotics, artificial intelligence, and machine learning approaches, cancer-associated mortalities and morbidities have shown continuous increments posing a healthcare burden. Drug-based interventions were associated with systemic toxicities and several limitations. Natural bioactive compounds derived nanoformulations, especially nanoquercetin (nQ), are alternative options to overcome drug-associated limitations. Moreover, the EVs-based cargo targeted delivery of nQ can have enormous potential in treating hepatocellular carcinoma (HCC). EVs-based nQ delivery synergistically regulates and dysregulates several pathways, including NF-κB, p53, JAK/STAT, MAPK, Wnt/β-catenin, and PI3K/AKT, along with PBX3/ERK1/2/CDK2, and miRNAs intonation. Furthermore, discoveries on possible checkpoints of anticancer signaling pathways were studied, which might lead to the development of modified EVs infused with nQ for the development of innovative treatments for HCC. In this work, we abridged the control of such signaling systems using a synergetic strategy with EVs and nQ. The governing roles of extracellular vesicles controlling the expression of miRNAs were investigated, particularly in relation to HCC.
has PII: cells13070638
doi: 10.3390/cells13070638
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Raghav A
      type: Person
      first name: Alok
      last name: Raghav
      member of: Department of Anatomy and Cell Biology, College of Medicine, Gachon University, 155 Getbeol-ro, Yeonsu-gu, Incheon 21999, Republic of Korea.
  slot:
    index: 2
    item: Jeong GB
      type: Person
      first name: Goo Bo
      last name: Jeong
      member of: Department of Anatomy and Cell Biology, College of Medicine, Gachon University, 155 Getbeol-ro, Yeonsu-gu, Incheon 21999, Republic of Korea.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D006528Q000473
has primary subject term: D008113Q000473
has primary subject term: D000067128Q000378
has primary subject term: D035683Q000235Q000378
has subject term: D006801
has subject term: D019869Q000378
has subject term: D001185
source: Cells. 2024-04-05;13(7):.
volume: 13

An Accessible Web-Based Survey to Monitor the Mental Health of People With Mild Intellectual Disability or Low Literacy Skills During the COVID-19 Pandemic: Comparative Data Analysis.
pmid: 38607229
abstract: The COVID-19 pandemic and related control measures affected the mental health of all populations. Particular subgroups are underrepresented in mainstream surveys because they are hard to reach, and study measurements are not adapted to their skills. These subgroups include people with lower cognitive and literacy skills, such as people with mild intellectual disability (MID), who were considered vulnerable during the COVID-19 pandemic given their low socioeconomic status, small social networks, increased risks of health problems, and difficulties understanding health-related information.This study examines the impact of the COVID-19 pandemic on mental health among people with MID or low literacy skills compared with those predominantly represented in national surveys.A repeated cross-sectional study of people with MID or low literacy skills and a general population sample was conducted in the Netherlands. An easy-read web-based survey was co-designed with, and tested among, people with MID or low literacy skills and conducted in 3 rounds within 1 year of the COVID-19 pandemic (T1: November to December 2020, T2: March to April 2021, and T3: September to October 2021). The survey contained questions about demographics and 6 aspects of mental health: feeling happy, feeling energized, feeling stressed, worry, feeling lonely, and sleeping problems.Our adapted survey and recruitment procedure enabled 1059 persons with MID or low literacy skills to participate (T1: n=412, 38.9%; T2: n=351, 33.1%; and T3: n=296, 28%). They were significantly younger, had a lower level of education, and more often than not were born outside the Netherlands compared to the general population sample (P<.001). Approximately half of them (604/1059, 57.03%) received professional care. They displayed poorer mental health scores than the general population sample. The percentages of people with MID or low literacy skills who reported more negative feelings in T1 ranged from 20.6% (85/412) reporting[cell cut: 3041 characters, first 2000 kept]
rights: ©Monique CJ Koks-Leensen, Anouk Menko, Fieke Raaijmakers, Gerdine AJ Fransen-Kuppens, Kirsten E Bevelander. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 30.05.2024.
has PII: v10i1e44827
doi: 10.2196/44827
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Koks-Leensen MC
      type: Person
      first name: Monique Cj
      last name: Koks-Leensen
      member of: Department of Primary and Community Care, Radboud university medical center, Nijmegen, Netherlands.Academic Collaborative Intellectual Disability and Health - Sterker op Eigen Benen (SOEB), Nijmegen, Netherlands.
  slot:
    index: 2
    item: Menko A
      type: Person
      first name: Anouk
      last name: Menko
      member of: Department of Primary and Community Care, Radboud university medical center, Nijmegen, Netherlands.Academic Collaborative AMPHI - Integrated Health Policy, Nijmegen, Netherlands.
  slot:
    index: 3
    item: Raaijmakers F
      type: Person
      first name: Fieke
      last name: Raaijmakers
      member of: Department of Primary and Community Care, Radboud university medical center, Nijmegen, Netherlands.Academic Collaborative AMPHI - Integrated Health Policy, Nijmegen, Netherlands.Safety and Health Region Gelderland-Midden, Arnhem, Netherlands.
  slot:
    index: 4
    item: Fransen-Kuppens GA
      type: Person
      first name: Gerdine Aj
      last name: Fransen-Kuppens
      member of: Department of Primary and Community Care, Radboud university medical center, Nijmegen, Netherlands.Academic Collaborative AMPHI - Integrated Health Policy, Nijmegen, Netherlands.Municipal Health Service Gelderland Zuid, Nijmegen, Netherlands.
  slot:
    index: 5
    item: Bevelander KE
      type: Person
      first name: Kirsten E
      last name: Bevelander
      member of: Department of Primary and Community Care, Radboud university medical center, Nijmegen, Netherlands.Academic Collaborative Intellectual Disability and Health - Sterker op Eigen Benen (SOEB), Nijmegen, Netherlands.Academic Collaborative AMPHI - Integrated Health Policy, Nijmegen, Netherlands.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-05-30
dp: 2024 05 30
created: 2024-4-12T09:25
e ISSN: 2369-2960
has issn l: 2369-2960
has NLM journal title abbreviation: JMIR Public Health Surveill
publication name: JMIR public health and surveillance
language: eng
has national library of medicine journal id: 101669345
derived from: NLM
pg: e44827
has place of publication: Canada
has primary subject term: D000086382Q000453Q000523
has primary subject term: D008603Q000706
has primary subject term: D008607Q000523Q000453
has subject term: D006801
has subject term: D008297
has subject term: D000328
has subject term: D005260
has subject term: D008875
has subject term: D003430
has subject term: D009426Q000453
has subject term: D011795
has subject term: D058873
has subject term: D000368
has subject term: D057220Q000706
has subject term: D020407
has subject term: D055815
has subject term: D000293
has subject term: D000067010Q000706
source: JMIR Public Health Surveill. 2024-05-30;10():e44827.
volume: 10

Design, optimization, and evaluation of topical gel of Cardiospermum halicacabum and Ricinus communis L. leaves extract for the treatment of rheumatoid arthritis.
pmid: 38613797
abstract: This research aims to develop and assess the anti-arthritic properties of a topically herbal gel including leaf extracts from Cardiospermum halicacabum and Ricinus communis L. in rats. Utilizing gelling agents carbopol 940 (2.5, 5, 7.5 g), nine herbal gel compositions were created. Prepared formulations were then assessed for physical appearance, spreadability, viscosity, net content, pH, extrudability, in vitro diffusion profile, and main skin irritant tests. According to the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) recommendations, the stability research for the topical herbal gel composition was completed, and Freund's Complete Adjuvant (FCA) induced arthritis technique was used to assess the anti-arthritic efficacy. Additional procedures included measuring the body weight, paw volume, biochemical and hematological variables, histological analysis, and in vitro serum biomarker detection. The prepared gels followed the instructions and were uniform and stable. F5 performed better than the other compositions in terms of release kinetics (97.20%). The gel proved safe and non-toxic since no erythema or edema was seen during the skin irritation test. Comparing the herbal gel F5 comprising carbopol 940 to rats with arthritis, the topical treatment showed considerable (p < .001) anti-arthritic effect. The anti-arthritic action of the gel formulations was confirmed by decreased paw volume, absence of agglutination in reacting protein and rheumatic factor, a decline in TNFα level, restoration to baseline biochemical and hematological characteristics, decrease in thymus and spleen weight, and histopathological study.
doi: 10.1080/09205063.2024.2340872
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ojha C
      type: Person
      first name: Chirag
      last name: Ojha
      member of: Department of Pharmaceutics, ShriRam College of Pharmacy, Banmore, India.
  slot:
    index: 2
    item: Sharma P
      type: Person
      first name: Pankaj
      last name: Sharma
      member of: Department of Pharmaceutics, ShriRam College of Pharmacy, Banmore, India.
  slot:
    index: 3
    item: Jain V
      type: Person
      first name: Vinay
      last name: Jain
      member of: Department of Pharmacognosy, ShriRam College of Pharmacy, Banmore, India.
created: 2024-4-13T20:44
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-13T12:53
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1584
ending page: 1605
has place of publication: England
has primary subject term: D018515Q000737
has primary subject term: D010936Q000737Q000494Q000008
has primary subject term: D005782Q000737
has primary subject term: D012278Q000737
has primary subject term: D001172Q000188
has subject term: D000818
has subject term: D051381
has subject term: D008297
has subject term: D000287
has subject term: D001169Q000188Q000473
has subject term: D017208
has subject term: D005620
has subject term: D014783
has subject term: D000180Q000737
source: J Biomater Sci Polym Ed. 2024-07;35(10):1584-1605.
volume: 35

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.
pmid: 38607079
abstract: Tight junctions are a barrier-forming cell-cell adhesion complex and have been proposed to regulate cell proliferation. However, the underlying mechanisms are not well understood. Here, we used cells deficient in the junction scaffold ZO-1 alone or together with its paralog ZO-2, which disrupts the junctional barrier. We found that ZO-1 knockout increased cell proliferation, induced loss of cell density-dependent proliferation control, and promoted apoptosis and necrosis. These phenotypes were enhanced by double ZO-1/ZO-2 knockout. Increased proliferation was dependent on two transcriptional regulators: YAP and ZONAB. ZO-1 knockout stimulated YAP nuclear translocation and activity without changes in Hippo-dependent phosphorylation. Knockout promoted TANK-binding kinase 1 (TBK1) activation and increased expression of the RhoA activator GEF-H1. Knockdown of ZO-3, another paralog interacting with ZO1, was sufficient to induce GEF-H1 expression and YAP activity. GEF-H1, TBK1, and mechanotransduction at focal adhesions were found to cooperate to activate YAP/TEAD in ZO-1-deficient cells. Thus, ZO-1 controled cell proliferation and Hippo-independent YAP activity by activating a GEF-H1- and TBK1-regulated mechanosensitive signalling network.
has PII: cells13070640
doi: 10.3390/cells13070640
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Haas AJ
      type: Person
      first name: Alexis J
      last name: Haas
      member of: UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
  slot:
    index: 2
    item: Karakus M
      type: Person
      first name: Mert
      last name: Karakus
      member of: UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
  slot:
    index: 3
    item: Zihni C
      type: Person
      first name: Ceniz
      last name: Zihni
      member of: UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
  slot:
    index: 4
    item: Balda MS
      type: Person
      first name: Maria S
      last name: Balda
      member of: UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
  slot:
    index: 5
    item: Matter K
      type: Person
      first name: Karl
      last name: Matter
      member of: UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D040542
has primary subject term: D015398
has subject term: D049109
has subject term: D020662Q000235Q000378
has subject term: D010766
has subject term: D000818
has subject term: D061985
has subject term: D004285
source: Cells. 2024-04-05;13(7):.
volume: 13

Unlocking the Future: Pluripotent Stem Cell-Based Lung Repair.
pmid: 38607074
abstract: The human respiratory system is susceptible to a variety of diseases, ranging from chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis to acute respiratory distress syndrome (ARDS). Today, lung diseases represent one of the major challenges to the health care sector and represent one of the leading causes of death worldwide. Current treatment options often focus on managing symptoms rather than addressing the underlying cause of the disease. The limitations of conventional therapies highlight the urgent clinical need for innovative solutions capable of repairing damaged lung tissue at a fundamental level. Pluripotent stem cell technologies have now reached clinical maturity and hold immense potential to revolutionize the landscape of lung repair and regenerative medicine. Meanwhile, human embryonic (HESCs) and human-induced pluripotent stem cells (hiPSCs) can be coaxed to differentiate into lung-specific cell types such as bronchial and alveolar epithelial cells, or pulmonary endothelial cells. This holds the promise of regenerating damaged lung tissue and restoring normal respiratory function. While methods for targeted genetic engineering of hPSCs and lung cell differentiation have substantially advanced, the required GMP-grade clinical-scale production technologies as well as the development of suitable preclinical animal models and cell application strategies are less advanced. This review provides an overview of current perspectives on PSC-based therapies for lung repair, explores key advances, and envisions future directions in this dynamic field.
has PII: cells13070635
doi: 10.3390/cells13070635
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Goecke T
      type: Person
      first name: Tobias
      last name: Goecke
      member of: Leibniz Research Laboratories for Biotechnology and Artificial Organs, Lower Saxony Center for Biomedical Engineering, Implant Research and Development /Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.Biomedical Research in End-stage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
  slot:
    index: 2
    item: Ius F
      type: Person
      first name: Fabio
      last name: Ius
      member of: Leibniz Research Laboratories for Biotechnology and Artificial Organs, Lower Saxony Center for Biomedical Engineering, Implant Research and Development /Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.Biomedical Research in End-stage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
  slot:
    index: 3
    item: Ruhparwar A
      type: Person
      first name: Arjang
      last name: Ruhparwar
      member of: Leibniz Research Laboratories for Biotechnology and Artificial Organs, Lower Saxony Center for Biomedical Engineering, Implant Research and Development /Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.Biomedical Research in End-stage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
  slot:
    index: 4
    item: Martin U
      type: Person
      first name: Ulrich
      last name: Martin
      member of: Leibniz Research Laboratories for Biotechnology and Artificial Organs, Lower Saxony Center for Biomedical Engineering, Implant Research and Development /Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.Biomedical Research in End-stage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
created: 2024-4-12T12:44
date last updated: 2025-01-17
issued: 2024-04-05
dp: 2024 04 05
created: 2024-4-12T09:23
e ISSN: 2073-4409
has issn l: 2073-4409
issue: 7
has NLM journal title abbreviation: Cells
publication name: Cells
language: eng
has national library of medicine journal id: 101600052
derived from: NLM
has place of publication: Switzerland
has primary subject term: D039904
has primary subject term: D057026Q000378
has primary subject term: D011658Q000378
has subject term: D000818
has subject term: D006801
has subject term: D042783
has subject term: D008168
source: Cells. 2024-04-05;13(7):.
volume: 13

The last giants: New evidence for giant Late Triassic (Rhaetian) ichthyosaurs from the UK.
pmid: 38630678
abstract: Giant ichthyosaurs with body length estimates exceeding 20 m were present in the latest Triassic of the UK. Here we report on the discovery of a second surangular from the lower jaw of a giant ichthyosaur from Somerset, UK. The new find is comparable in size and morphology to a specimen from Lilstock, Somerset, described in 2018, but it is more complete and better preserved. Both finds are from the uppermost Triassic Westbury Mudstone Formation (Rhaetian), but the new specimen comes from Blue Anchor, approximately 10 km west along the coast from Lilstock. The more complete surangular would have been >2 m long, from an individual with a body length estimated at ~25 m. The identification of two specimens with the same unique morphology and from the same geologic age and geographic location warrants the erection of a new genus and species, Ichthyotitan severnensis gen. et sp. nov. Thin sections of the new specimen revealed the same histological features already observed in similar giant ichthyosaurian specimens. Our data also supports the previous suggestion of an atypical osteogenesis in the lower jaws of giant ichthyosaurs. The geological age and giant size of the specimens suggest shastasaurid affinities, but the material is too incomplete for a definitive referral. Ichthyotitan severnensis gen. et sp. nov., is the first-named giant ichthyosaur from the Rhaetian and probably represents the largest marine reptile formally described.
rights: Copyright: © 2024 Lomax et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
has PII: PONE-D-23-38486
doi: 10.1371/journal.pone.0300289
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Lomax DR
      type: Person
      first name: Dean R
      last name: Lomax
      member of: Palaeobiology Research Group, School of Earth Sciences, University of Bristol, Bristol, United Kingdom.Department of Earth and Environmental Sciences, The University of Manchester, Manchester, United Kingdom.
  slot:
    index: 2
    item: de la Salle P
      type: Person
      first name: Paul
      last name: de la Salle
      member of: The Etches Collection - Museum of Jurassic Marine Life, Dorset, United Kingdom.
  slot:
    index: 3
    item: Perillo M
      type: Person
      first name: Marcello
      last name: Perillo
      member of: Paleontology division, Institute of Geosciences, University of Bonn, Bonn, Germany.
  slot:
    index: 4
    item: Reynolds J
      type: Person
      first name: Justin
      last name: Reynolds
      member of: Braunton, Devon, United Kingdom.
  slot:
    index: 5
    item: Reynolds R
      type: Person
      first name: Ruby
      last name: Reynolds
      member of: Braunton, Devon, United Kingdom.
  slot:
    index: 6
    item: Waldron JF
      type: Person
      first name: James F
      last name: Waldron
      member of: Dinosaurs Will Always Be Awesome, DWABA Museum, Orlando, Florida, United States of America.
created: 2024-4-17T18:42
date last updated: 2025-01-17
issued: 2024
dp: 2024
created: 2024-4-17T13:34
e ISSN: 1932-6203
has issn l: 1932-6203
issue: 4
has NLM journal title abbreviation: PLoS One
publication name: PloS one
language: eng
has national library of medicine journal id: 101285081
derived from: NLM
pg: e0300289
has place of publication: United States
has primary subject term: D005075
has primary subject term: D005580
has subject term: D000818
has subject term: D010802
has subject term: D012104
has subject term: D006113
source: PLoS One. 2024;19(4):e0300289.
volume: 19

Oxidized sodium alginate hydrogel-mouse nerve growth factor sustained release system promotes repair of peripheral nerve injury.
pmid: 38630632
abstract: In recent years, mouse nerve growth factor (mNGF) has emerged as an important biological regulator to repair peripheral nerve injury, but its systemic application is restricted by low efficiency and large dosage requirement. These limitations prompted us to search for biomaterials that can be locally loaded. Oxidized sodium alginate hydrogel (OSA) exhibits good biocompatibility and physicochemical properties, and can be loaded with drugs to construct a sustained-release system that can act locally on nerve injury. Here, we constructed a sustained-release system of OSA-mouse nerve growth factor (mNGF), and investigated the loading and release of the drug through Fourier transform infrared spectroscopy and drug release curves. In vitro and in vivo experiments showed that OSA-mNGF significantly promoted the biological activities of RSC-96 cells and facilitated the recovery from sciatic nerve crush injury in rats. This observation may be attributed to the additive effect of OSA on promoting Schwann cell biological activities or its synergistic effect of cross-activating phosphoinositide 3-kinase (PI3K) through extracellular signal regulated kinase (ERK) signaling. Although the specific mechanism of OSA action needs to be explored in the future, the current results provide a valuable preliminary research basis for the clinical application of the OSA-mNGF sustained-release system for nerve repair.
doi: 10.1080/09205063.2024.2339636
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Sun Y
      type: Person
      first name: Yuming
      last name: Sun
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 2
    item: Sun X
      type: Person
      first name: Xiangyu
      last name: Sun
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 3
    item: Wang R
      type: Person
      first name: Ruiqi
      last name: Wang
      member of: School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
  slot:
    index: 4
    item: Xing Y
      type: Person
      first name: Yuhang
      last name: Xing
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 5
    item: Ma X
      type: Person
      first name: Xiang
      last name: Ma
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 6
    item: Yue J
      type: Person
      first name: Jie
      last name: Yue
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 7
    item: Zhang M
      type: Person
      first name: Min
      last name: Zhang
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 8
    item: Wang Y
      type: Person
      first name: Yuezhu
      last name: Wang
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
  slot:
    index: 9
    item: Tian W
      type: Person
      first name: Weiming
      last name: Tian
      member of: School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
  slot:
    index: 10
    item: Jing G
      type: Person
      first name: Guangping
      last name: Jing
      member of: Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China.
created: 2024-4-17T18:42
date last updated: 2025-01-17
issued: 2024-07
dp: 2024 07
created: 2024-4-17T13:12
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 10
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1550
ending page: 1570
has place of publication: England
has primary subject term: D000464Q000737Q000494
has primary subject term: D020932Q000737
has primary subject term: D003692Q000737
has primary subject term: D020100Q000737Q000494
has primary subject term: D059348Q000188Q000378
has primary subject term: D065546
has subject term: D000818
has subject term: D051379
has subject term: D051381
has subject term: D012583Q000187Q000378
has subject term: D012584Q000293Q000187
has subject term: D009416Q000187
has subject term: D010084
has subject term: D002460
has subject term: D008297
has subject term: D017207
has subject term: D004337Q000737
has subject term: D019869Q000378
source: J Biomater Sci Polym Ed. 2024-07;35(10):1550-1570.
volume: 35

Ensuring a safe, tobacco free future for the young: protecting children from tobacco industry interference.
pmid: 38641358
has PII: tc-2024-058698
doi: 10.1136/tc-2024-058698
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Assunta M
      type: Person
      first name: Mary
      last name: Assunta
      member of: Southeast Asia Tobacco Control Alliance, Bangkok, Thailand mary.assunta@cancer.org.au.Advocacy at Global Center for Good Governance in Tobacco Control, Bangkok, Thailand.
  slot:
    index: 2
    item: Chamberlain P
      type: Person
      first name: Phil
      last name: Chamberlain
      member of: Tobacco Control Research Group at the University of Bath, Bath, UK.
created: 2024-4-20T00:42
date last updated: 2025-01-17
issued: 2024-04-19
dp: 2024 Apr 19
created: 2024-4-19T20:43
e ISSN: 1468-3318
has issn l: 0964-4563
issue: 3
has NLM journal title abbreviation: Tob Control
publication name: Tobacco control
language: eng
has national library of medicine journal id: 9209612
derived from: NLM
starting page: 281
ending page: 282
has place of publication: England
has primary subject term: D019460
has subject term: D002648
has subject term: D006801
has subject term: D000329
source: Tob Control. 2024-04-19;33(3):281-282.
volume: 33

Profiles of functioning of a group of children with cerebral palsy in Argentina: Preliminary data from the first national study.
pmid: 38656786
abstract: Cerebral palsy (CP) affects body posture and movement coordination and is the most common cause of severe disability in the pediatric population. The diagnosis of CP is not a description of a person's functioning or interaction with their environment. Therefore, the diagnosis should be complemented with a description of functioning, using tools based on the biopsychosocial model proposed by the World Health Organization's International Classification of Functioning, Disability and Health (ICF). This report describes the preliminary data from a multicenter study conducted in Argentina with the aim of standardizing the description of the profiles of functioning of children and adolescents with CP. These data showed that the participants had some skills in sleep functions, mental functions of language, seeing functions, and in some environmental factors. They showed significant difficulties in categories such as maintaining body position, walking, and toileting.
rights: Sociedad Argentina de Pediatría.
doi: 10.5546/aap.2023-10257.eng
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Escobar LJ
      type: Person
      first name: L Johana
      last name: Escobar
      member of: Institute for Research in Health Sciences (Instituto de Investigaciones en Ciencias de la Salud, INICSA)-National Scientific and Technical Research Council (Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET), School of Medical Sciences, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 2
    item: Schiariti V
      type: Person
      first name: Verónica
      last name: Schiariti
      member of: Division of Medical Sciences, University of Victoria, British Columbia, Canada.
  slot:
    index: 3
    item: Ruiz Brunner M
      type: Person
      first name: Mercedes
      last name: Ruiz Brunner
      member of: Institute for Research in Health Sciences (Instituto de Investigaciones en Ciencias de la Salud, INICSA)-National Scientific and Technical Research Council (Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET), School of Medical Sciences, Universidad Nacional de Córdoba, Córdoba, Argentina.
  slot:
    index: 4
    item: Cuestas E
      type: Person
      first name: Eduardo
      last name: Cuestas
      member of: Institute for Research in Health Sciences (Instituto de Investigaciones en Ciencias de la Salud, INICSA)-National Scientific and Technical Research Council (Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET), School of Medical Sciences, Universidad Nacional de Córdoba, Córdoba, Argentina.
created: 2024-4-24T19:05
date last updated: 2025-01-17
issued: 2024-12-01
dp: 2024 12 01
created: 2024-4-24T12:17
e ISSN: 1668-3501
has issn l: 0325-0075
issue: 6
has NLM journal title abbreviation: Arch Argent Pediatr
publication name: Archivos argentinos de pediatria
language: engspa
has national library of medicine journal id: 0372460
rights holder: La parálisis cerebral (PC) afecta la postura y la coordinación del movimiento, y es la causa más común de discapacidad grave en la población pediátrica. El diagnóstico de PC no describe el funcionamiento ni la interacción de la persona con el contexto en el cual se desarrolla. Por lo tanto, el diagnóstico se debe complementar con una descripción del funcionamiento, utilizando herramientas basadas en el modelo biopsicosocial de la Clasificación del Funcionamiento (CIF) de la Organización Mundial de la Salud (OMS). En esta comunicación, describimos los datos preliminares de un estudio multicéntrico en Argentina destinado a estandarizar la descripción del perfil de funcionamiento en niños y adolescentes con PC. Estos datos mostraron que los participantes tienen algunas habilidades en las funciones del sueño, las funciones mentales del lenguaje y las visuales, así como en algunas relacionadas con el contexto. Presentan dificultades importantes en categorías tales como mantener la posición del cuerpo, el andar y la higiene.
derived from: NLM
pg: e202310257
has place of publication: Argentina
has primary subject term: D002547Q000503Q000175
has subject term: D006801
has subject term: D001118
has subject term: D002648
has subject term: D008297
has subject term: D000293
has subject term: D005260
has subject term: D002675
has subject term: D004185
source: Arch Argent Pediatr. 2024-12-01;122(6):e202310257.
volume: 122

Enhancing antibacterial properties of titanium implants through a novel Ag-TiO2-OTS nanocomposite coating: a comprehensive study on resist-killing-disintegrate approach.
pmid: 38652755
abstract: Titanium (Ti) implants are widely used in orthopedic and dental applications due to their excellent biocompatibility and mechanical properties. However, bacterial adhesion and subsequent biofilm formation on implant surfaces pose a significant risk of postoperative infections and complications. Conventional surface modifications often lack long-lasting antibacterial efficacy, necessitating the development of novel coatings with enhanced antimicrobial properties. This study aims to develop a novel Ag-TiO2-OTS (Silver-Titanium dioxide-Octadecyltrichlorosilane, ATO) nanocomposite coating, through a chemical plating method. By employing a 'resist-killing-disintegrate' approach, the coating is designed to inhibit bacterial adhesion effectively, and facilitate pollutant removal with lasting effects. Characterization of the coatings was performed using spectroscopy, electron microscopy, and contact angle analysis. Antibacterial efficacy, quantitatively evaluated against E. coli and S. aureus over 168 h, showed a significant reduction in bacterial adhesion by 76.6% and 66.5% respectively, and bacterial removal rates were up to 83.8% and 73.3% in comparison to uncoated Ti-base material. Additionally, antibacterial assays indicated that the ratio of the Lifshitz-van der Waals apolar component to electron donor surface energy components significantly influences bacterial adhesion and removal, underscoring a tunable parameter for optimizing antibacterial surfaces. Biocompatibility assessments with the L929 cell line revealed that the ATO coatings exhibited excellent biocompatibility, with minimal cytotoxicity and no significant impact on cell proliferation or apoptosis. The ATO coatings provided a multi-functionality surface that not only resists bacterial colonization but also possesses self-cleaning capabilities, thereby marking a substantial advancement in the development of antibacterial coatings for medical implants.
doi: 10.1080/09205063.2024.2344332
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Jiang Y
      type: Person
      first name: Yu
      last name: Jiang
      member of: Department of Chemical Biology, School of Pharmaceutical Science, Capital Medical University, Beijing, China.
  slot:
    index: 2
    item: Wan Z
      type: Person
      first name: Zhou
      last name: Wan
      member of: Department of Beijing Anding Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 3
    item: Liu Q
      type: Person
      first name: Qi
      last name: Liu
      member of: Department of Chemical Biology, School of Pharmaceutical Science, Capital Medical University, Beijing, China.
  slot:
    index: 4
    item: Li X
      type: Person
      first name: Xinxin
      last name: Li
      member of: Department of Chemical Biology, School of Pharmaceutical Science, Capital Medical University, Beijing, China.
  slot:
    index: 5
    item: Jiang B
      type: Person
      first name: Bo
      last name: Jiang
      member of: NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing Institute for Food and Drug Control, Chongqing, China.
  slot:
    index: 6
    item: Guo M
      type: Person
      first name: Mudan
      last name: Guo
      member of: NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing Institute for Food and Drug Control, Chongqing, China.
  slot:
    index: 7
    item: Fan P
      type: Person
      first name: Pengjue
      last name: Fan
      member of: Chongqing Zhengbo Biotech Ltd, Chongqing, China.
  slot:
    index: 8
    item: Du S
      type: Person
      first name: Siyi
      last name: Du
      member of: Chongqing Nankai Secondary School, Chongqing, China.
  slot:
    index: 9
    item: Xu D
      type: Person
      first name: Doudou
      last name: Xu
      member of: NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing Institute for Food and Drug Control, Chongqing, China.
  slot:
    index: 10
    item: Liu C
      type: Person
      first name: Chen
      last name: Liu
      member of: Department of Chemical Biology, School of Pharmaceutical Science, Capital Medical University, Beijing, China.Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, China.
created: 2024-4-23T18:50
date last updated: 2025-01-17
issued: 2024-08
dp: 2024 08
created: 2024-4-23T13:53
e ISSN: 1568-5624
has issn l: 0920-5063
issue: 11
has NLM journal title abbreviation: J Biomater Sci Polym Ed
publication name: Journal of biomaterials science. Polymer edition
language: eng
has national library of medicine journal id: 9007393
derived from: NLM
starting page: 1609
ending page: 1630
has place of publication: England
has primary subject term: D014025Q000737Q000494
has primary subject term: D000900Q000494Q000737
has primary subject term: D012834Q000737Q000494
has primary subject term: D013211Q000187
has primary subject term: D053761Q000737
has primary subject term: D020099Q000737Q000494
has primary subject term: D004926Q000187
has primary subject term: D001422Q000187
has primary subject term: D019736
has subject term: D013499
has subject term: D012821Q000737Q000494
has subject term: D018441Q000187
has subject term: D002460
has subject term: D006801
has subject term: D051379
has subject term: D008826
has subject term: D008422
has subject term: D000818
source: J Biomater Sci Polym Ed. 2024-08;35(11):1609-1630.
volume: 35

ASCOD phenotyping of acute vertebrobasilar artery occlusion treated by mechanical thrombectomy: insight from the PERSIST registry.
pmid: 38669707
abstract: Determining the underlying etiology of acute vertebrobasilar artery occlusion (VBAO) is crucial for selecting an appropriate treatment approach. The authors aimed to investigate the distribution of etiology and the association with functional outcomes in patients with acute VBAO who underwent endovascular treatment in which atherosclerosis, small-vessel disease, cardiac pathology, other causes, and dissection (ASCOD) phenotyping was used.A retrospective study was conducted at 21 centers in China, involving patients with VBAO who received endovascular treatment within 24 hours of the estimated occlusion time. In the ASCOD phenotyping, each phenotype is graded based on the following categories: 1, likely to be causal; 2, uncertain if causal; and 3, unlikely to be causal. The authors defined a single possible cause as a cause graded 1 in a single domain, and multiple possible causes were graded 1 or 2 regardless of overlap. The primary outcome was unfavorable outcome (modified Rankin Scale [mRS] score of 3-6) at 90 days. The secondary outcomes included shift of mRS score at 90 days, 90-day mortality, successful reperfusion, and National Institutes of Health Stroke Scale score at 24 hours. Multivariable regression analysis was used to assess the association between etiological subtypes and functional outcomes. Multivariate competing-risk regression analysis was performed to analyze the association between etiological subtypes and the risk of recurrent stroke.A total of 577 patients were included in this study. Of these, 521 (90%) had a single possible cause. The most common etiology was A1 (382 cases, 73%), followed by C1 (111 cases, 21%) and O1 (28 cases, 5%-in this study the other causes and dissection subtypes were categorized under the umbrella term of O causes). Similar patterns were observed in the multiple possible causes. In the baseline characteristics of the cohort, as rescue therapy, stenting was more frequently used in patients in the A1 group than in the C1[cell cut: 3073 characters, first 2000 kept]
doi: 10.3171/2024.1.JNS232508
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Hu M
      type: Person
      first name: Miaomiao
      last name: Hu
      member of: 1Graduate School of Bengbu Medical University, Bengbu, Anhui, China.
  slot:
    index: 2
    item: Xu Y
      type: Person
      first name: Yingjie
      last name: Xu
      member of: 2Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
  slot:
    index: 3
    item: Huang K
      type: Person
      first name: Kai
      last name: Huang
      member of: 3Department of Neurology, The Second Hospital of Weinan, Shanxi, China.
  slot:
    index: 4
    item: Luan H
      type: Person
      first name: Huanhuan
      last name: Luan
      member of: 4Department of Neurology, Lu'an Fourth People's Hospital, Anhui, China.
  slot:
    index: 5
    item: Zuo K
      type: Person
      first name: Kun
      last name: Zuo
      member of: 5Department of Neurology, Hospital of Traditional Chinese Medicine of Feidong, Hefei, Anhui, China.
  slot:
    index: 6
    item: Liu Y
      type: Person
      first name: Yuanlu
      last name: Liu
      member of: 6Department of Neurology, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, Jiangxi, China.
  slot:
    index: 7
    item: Wang S
      type: Person
      first name: Songlin
      last name: Wang
      member of: 5Department of Neurology, Hospital of Traditional Chinese Medicine of Feidong, Hefei, Anhui, China.
  slot:
    index: 8
    item: Wang M
      type: Person
      first name: Meng
      last name: Wang
      member of: 7Department of Neurology, The Second People's Hospital of Huoqiu County, Lu' an, Anhui, China; and.
  slot:
    index: 9
    item: Zhang P
      type: Person
      first name: Pan
      last name: Zhang
      member of: 2Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
  slot:
    index: 10
    item: Chen H
      type: Person
      first name: Hao
      last name: Chen
      member of: 8Department of Neurology, The First Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  slot:
    index: 11
    item: Sun W
      type: Person
      first name: Wen
      last name: Sun
      member of: 1Graduate School of Bengbu Medical University, Bengbu, Anhui, China.2Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
created: 2024-4-26T18:53
date last updated: 2025-01-17
issued: 2024-10-01
dp: 2024 Oct 01
created: 2024-4-26T17:53
e ISSN: 1933-0693
has issn l: 0022-3085
issue: 4
has NLM journal title abbreviation: J Neurosurg
publication name: Journal of neurosurgery
language: eng
has national library of medicine journal id: 0253357
derived from: NLM
starting page: 983
ending page: 991
has place of publication: United States
has primary subject term: D012042
has primary subject term: D014715Q000601
has primary subject term: D010641
has primary subject term: D057510Q000379
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D005260
has subject term: D012189
has subject term: D000368
has subject term: D016896
has subject term: D017131Q000379
has subject term: D002681Q000453
has subject term: D000784Q000601
source: J Neurosurg. 2024-10-01;141(4):983-991.
volume: 141

Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe.
pmid: 38669706
abstract: The aim of this study was to compare the outcomes of early (≤ 90 days) and delayed (> 90 days) cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI).The authors analyzed participants enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) and the Neurotraumatology Quality Registry (Net-QuRe) studies who were diagnosed with TBI and underwent DC and subsequent cranioplasty. These prospective, multicenter, observational cohort studies included 5091 patients enrolled from 2014 to 2020. The effect of cranioplasty timing on functional outcome was evaluated with multivariable ordinal regression and with propensity score matching (PSM) in a sensitivity analysis of functional outcome (Glasgow Outcome Scale-Extended [GOSE] score) and quality of life (Quality of Life After Brain Injury [QOLIBRI] instrument) at 12 months following DC.Among 173 eligible patients, 73 (42%) underwent early cranioplasty and 100 (58%) underwent delayed cranioplasty. In the ordinal logistic regression and PSM, similar 12-month GOSE scores were found between the two groups (adjusted odds ratio [aOR] 0.87, 95% CI 0.61-1.21 and 0.88, 95% CI 0.48-1.65, respectively). In the ordinal logistic regression, early cranioplasty was associated with a higher risk for hydrocephalus than that with delayed cranioplasty (aOR 4.0, 95% CI 1.2-16). Postdischarge seizure rates (early cranioplasty: aOR 1.73, 95% CI 0.7-4.7) and QOLIBRI scores (β -1.9, 95% CI -9.1 to 9.6) were similar between the two groups.Functional outcome and quality of life were similar between early and delayed cranioplasty in patients who had undergone DC for TBI. Neurosurgeons may consider performing cranioplasty during the index admission (early) to simplify the patient's chain of care and prevent readmission for cranioplasty but should be vigilant for an increased possibility of hydrocephalus. Clinical trial registration nos.: CENTER-TBI, NCT022[cell cut: 2103 characters, first 2000 kept]
doi: 10.3171/2024.1.JNS232172
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Vreeburg RJG
      type: Person
      first name: Rick J G
      last name: Vreeburg
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 2
    item: Singh RD
      type: Person
      first name: Ranjit D
      last name: Singh
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 3
    item: van Erp IAM
      type: Person
      first name: Inge A M
      last name: van Erp
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 4
    item: Korhonen TK
      type: Person
      first name: Tommi K
      last name: Korhonen
      member of: 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom.3Neurocenter, Department of Neurosurgery and Research Unit of Clinical Neuroscience, Neurosurgery, Oulu University Hospital and University of Oulu, Finland.
  slot:
    index: 5
    item: Yue JK
      type: Person
      first name: John K
      last name: Yue
      member of: 4Department of Neurosurgery, University of California, San Francisco, California.
  slot:
    index: 6
    item: Mee H
      type: Person
      first name: Harry
      last name: Mee
      member of: 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom.
  slot:
    index: 7
    item: Timofeev I
      type: Person
      first name: Ivan
      last name: Timofeev
      member of: 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom.
  slot:
    index: 8
    item: Kolias A
      type: Person
      first name: Angelos
      last name: Kolias
      member of: 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom.
  slot:
    index: 9
    item: Helmy A
      type: Person
      first name: Adel
      last name: Helmy
      member of: 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom.
  slot:
    index: 10
    item: Depreitere B
      type: Person
      first name: Bart
      last name: Depreitere
      member of: 5Department of Neurosurgery, University Hospital Leuven, Belgium.
  slot:
    index: 11
    item: Moojen WA
      type: Person
      first name: Wouter A
      last name: Moojen
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 12
    item: Younsi A
      type: Person
      first name: Alexander
      last name: Younsi
      member of: 6Department of Neurosurgery, University Hospital Heidelberg, Germany.
  slot:
    index: 13
    item: Hutchinson P
      type: Person
      first name: Peter
      last name: Hutchinson
      member of: 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom.
  slot:
    index: 14
    item: Manley GT
      type: Person
      first name: Geoffrey T
      last name: Manley
      member of: 4Department of Neurosurgery, University of California, San Francisco, California.
  slot:
    index: 15
    item: Steyerberg EW
      type: Person
      first name: Ewout W
      last name: Steyerberg
      member of: 7Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
  slot:
    index: 16
    item: de Ruiter GCW
      type: Person
      first name: Godard C W
      last name: de Ruiter
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 17
    item: Maas AIR
      type: Person
      first name: Andrew I R
      last name: Maas
      member of: 8Department of Neurosurgery, Antwerp University Hospital, Edegem, Belgium.9Department of Translational Neuroscience, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium.
  slot:
    index: 18
    item: Peul WC
      type: Person
      first name: Wilco C
      last name: Peul
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 19
    item: van Dijck JTJM
      type: Person
      first name: Jeroen T J M
      last name: van Dijck
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 20
    item: den Boogert HF
      type: Person
      first name: Hugo F
      last name: den Boogert
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.
  slot:
    index: 21
    item: Posti JP
      type: Person
      first name: Jussi P
      last name: Posti
      member of: 10Neurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Finland; and.
  slot:
    index: 22
    item: van Essen TA
      type: Person
      first name: Thomas A
      last name: van Essen
      member of: 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands.11Department of Surgery, Division of Neurosurgey, QEII Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.
creator: for the CENTER-TBI Participants and Investigators
created: 2024-4-26T18:53
date last updated: 2025-01-17
issued: 2024-10-01
dp: 2024 Oct 01
created: 2024-4-26T17:53
contributor: OrderedList
  length: 251
  slot:
    index: 1
    item: Åkerlund C
      type: Person
      first name: Cecilia
      last name: Åkerlund
  slot:
    index: 2
    item: Amrein K
      type: Person
      first name: Krisztina
      last name: Amrein
  slot:
    index: 3
    item: Andelic N
      type: Person
      first name: Nada
      last name: Andelic
  slot:
    index: 4
    item: Andreassen L
      type: Person
      first name: Lasse
      last name: Andreassen
  slot:
    index: 5
    item: Anke A
      type: Person
      first name: Audny
      last name: Anke
  slot:
    index: 6
    item: Antoni A
      type: Person
      first name: Anna
      last name: Antoni
e ISSN: 1933-0693
has issn l: 0022-3085
issue: 4
has NLM journal title abbreviation: J Neurosurg
publication name: Journal of neurosurgery
language: eng
has national library of medicine journal id: 0253357
derived from: NLM
starting page: 895
ending page: 907
has place of publication: United States
has primary subject term: D056424Q000379
has primary subject term: D000070642Q000601Q000150
has primary subject term: D011788
has subject term: D006801
has subject term: D008297
has subject term: D005260
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has subject term: D011446
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has subject term: D019651Q000379
has subject term: D015331
has subject term: D013997
has subject term: D012042
has subject term: D061665
source: J Neurosurg. 2024-10-01;141(4):895-907.
volume: 141

index: 7
item: Audibert G
  type: Person
  first name: Gérard
  last name: Audibert

index: 8
item: Azouvi P
  type: Person
  first name: Philippe
  last name: Azouvi

index: 9
item: Azzolini ML
  type: Person
  first name: Maria Luisa
  last name: Azzolini

index: 10
item: Bartels R
  type: Person
  first name: Ronald
  last name: Bartels

index: 11
item: Barzó P
  type: Person
  first name: Pál
  last name: Barzó

index: 12
item: Beauvais R
  type: Person
  first name: Romuald
  last name: Beauvais

index: 13
item: Beer R
  type: Person
  first name: Ronny
  last name: Beer

index: 14
item: Bellander BM
  type: Person
  first name: Bo-Michael
  last name: Bellander

index: 15
item: Belli A
  type: Person
  first name: Antonio
  last name: Belli

index: 16
item: Benali H
  type: Person
  first name: Habib
  last name: Benali

index: 17
item: Berardino M
  type: Person
  first name: Maurizio
  last name: Berardino

index: 18
item: Beretta L
  type: Person
  first name: Luigi
  last name: Beretta

index: 19
item: Blaabjerg M
  type: Person
  first name: Morten
  last name: Blaabjerg

index: 20
item: Bragge P
  type: Person
  first name: Peter
  last name: Bragge

index: 21
item: Brazinova A
  type: Person
  first name: Alexandra
  last name: Brazinova

index: 22
item: Brinck V
  type: Person
  first name: Vibeke
  last name: Brinck

index: 23
item: Brooker J
  type: Person
  first name: Joanne
  last name: Brooker

index: 24
item: Brorsson C
  type: Person
  first name: Camilla
  last name: Brorsson

index: 25
item: Buki A
  type: Person
  first name: Andras
  last name: Buki

index: 26
item: Bullinger M
  type: Person
  first name: Monika
  last name: Bullinger

index: 27
item: Cabeleira M
  type: Person
  first name: Manuel
  last name: Cabeleira

index: 28
item: Caccioppola A
  type: Person
  first name: Alessio
  last name: Caccioppola

index: 29
item: Calappi E
  type: Person
  first name: Emiliana
  last name: Calappi

index: 30
item: Calvi MR
  type: Person
  first name: Maria Rosa
  last name: Calvi

index: 31
item: Cameron P
  type: Person
  first name: Peter
  last name: Cameron

index: 32
item: Lozano GC
  type: Person
  first name: Guillermo Carbayo
  last name: Lozano

index: 33
item: Carbonara M
  type: Person
  first name: Marco
  last name: Carbonara

index: 34
item: Cavallo S
  type: Person
  first name: Simona
  last name: Cavallo

index: 35
item: Chevallard G
  type: Person
  first name: Giorgio
  last name: Chevallard

index: 36
item: Chieregato A
  type: Person
  first name: Arturo
  last name: Chieregato

index: 37
item: Citerio G
  type: Person
  first name: Giuseppe
  last name: Citerio

index: 38
item: Clusmann H
  type: Person
  first name: Hans
  last name: Clusmann

index: 39
item: Coburn M
  type: Person
  first name: Mark
  last name: Coburn

index: 40
item: Coles J
  type: Person
  first name: Jonathan
  last name: Coles

index: 41
item: Cooper JD
  type: Person
  first name: Jamie D
  last name: Cooper

index: 42
item: Correia M
  type: Person
  first name: Marta
  last name: Correia

index: 43
item: Čović A
  type: Person
  first name: Amra
  last name: Čović

index: 44
item: Curry N
  type: Person
  first name: Nicola
  last name: Curry

index: 45
item: Czeiter E
  type: Person
  first name: Endre
  last name: Czeiter

index: 46
item: Czosnyka M
  type: Person
  first name: Marek
  last name: Czosnyka

index: 47
item: Dahyot-Fizelier C
  type: Person
  first name: Claire
  last name: Dahyot-Fizelier

index: 48
item: Dark P
  type: Person
  first name: Paul
  last name: Dark

index: 49
item: Dawes H
  type: Person
  first name: Helen
  last name: Dawes

index: 50
item: De Keyser V
  type: Person
  first name: Véronique
  last name: De Keyser

index: 51
item: Degos V
  type: Person
  first name: Vincent
  last name: Degos

index: 52
item: Della Corte F
  type: Person
  first name: Francesco
  last name: Della Corte

index: 53
item: den Boogert H
  type: Person
  first name: Hugo
  last name: den Boogert

index: 54
item: Depreitere B
  type: Person
  first name: Bart
  last name: Depreitere

index: 55
item: Đilvesi Đ
  type: Person
  first name: Đula
  last name: Đilvesi

index: 56
item: Dixit A
  type: Person
  first name: Abhishek
  last name: Dixit

index: 57
item: Donoghue E
  type: Person
  first name: Emma
  last name: Donoghue

index: 58
item: Dreier J
  type: Person
  first name: Jens
  last name: Dreier

index: 59
item: Dulière GL
  type: Person
  first name: Guy-Loup
  last name: Dulière

index: 60
item: Ercole A
  type: Person
  first name: Ari
  last name: Ercole

index: 61
item: Esser P
  type: Person
  first name: Patrick
  last name: Esser

index: 62
item: Ezer E
  type: Person
  first name: Erzsébet
  last name: Ezer

index: 63
item: Fabricius M
  type: Person
  first name: Martin
  last name: Fabricius

index: 64
item: Feigin VL
  type: Person
  first name: Valery L
  last name: Feigin

index: 65
item: Foks K
  type: Person
  first name: Kelly
  last name: Foks

index: 66
item: Frisvold S
  type: Person
  first name: Shirin
  last name: Frisvold

index: 67
item: Furmanov A
  type: Person
  first name: Alex
  last name: Furmanov

index: 68
item: Gagliardo P
  type: Person
  first name: Pablo
  last name: Gagliardo

index: 69
item: Galanaud D
  type: Person
  first name: Damien
  last name: Galanaud

index: 70
item: Gantner D
  type: Person
  first name: Dashiell
  last name: Gantner

index: 71
item: Gao G
  type: Person
  first name: Guoyi
  last name: Gao

index: 72
item: George P
  type: Person
  first name: Pradeep
  last name: George

index: 73
item: Ghuysen A
  type: Person
  first name: Alexandre
  last name: Ghuysen

index: 74
item: Giga L
  type: Person
  first name: Lelde
  last name: Giga

index: 75
item: Glocker B
  type: Person
  first name: Ben
  last name: Glocker

index: 76
item: Golubovic J
  type: Person
  first name: Jagoš
  last name: Golubovic

index: 77
item: Gomez PA
  type: Person
  first name: Pedro A
  last name: Gomez

index: 78
item: Gratz J
  type: Person
  first name: Johannes
  last name: Gratz

index: 79
item: Gravesteijn B
  type: Person
  first name: Benjamin
  last name: Gravesteijn

index: 80
item: Grossi F
  type: Person
  first name: Francesca
  last name: Grossi

index: 81
item: Gruen RL
  type: Person
  first name: Russell L
  last name: Gruen

index: 82
item: Gupta D
  type: Person
  first name: Deepak
  last name: Gupta

index: 83
item: Haagsma JA
  type: Person
  first name: Juanita A
  last name: Haagsma

index: 84
item: Haitsma I
  type: Person
  first name: Iain
  last name: Haitsma

index: 85
item: Helbok R
  type: Person
  first name: Raimund
  last name: Helbok

index: 86
item: Helseth E
  type: Person
  first name: Eirik
  last name: Helseth

index: 87
item: Horton L
  type: Person
  first name: Lindsay
  last name: Horton

index: 88
item: Huijben J
  type: Person
  first name: Jilske
  last name: Huijben

index: 89
item: Hutchinson PJ
  type: Person
  first name: Peter J
  last name: Hutchinson

index: 90
item: Jacobs B
  type: Person
  first name: Bram
  last name: Jacobs

index: 91
item: Jankowski S
  type: Person
  first name: Stefan
  last name: Jankowski

index: 92
item: Jarrett M
  type: Person
  first name: Mike
  last name: Jarrett

index: 93
item: Jiang JY
  type: Person
  first name: Ji-Yao
  last name: Jiang

index: 94
item: Johnson F
  type: Person
  first name: Faye
  last name: Johnson

index: 95
item: Jones K
  type: Person
  first name: Kelly
  last name: Jones

index: 96
item: Karan M
  type: Person
  first name: Mladen
  last name: Karan

index: 97
item: Kolias AG
  type: Person
  first name: Angelos G
  last name: Kolias

index: 98
item: Kompanje E
  type: Person
  first name: Erwin
  last name: Kompanje

index: 99
item: Kondziella D
  type: Person
  first name: Daniel
  last name: Kondziella

index: 100
item: Kornaropoulos E
  type: Person
  first name: Evgenios
  last name: Kornaropoulos

index: 101
item: Koskinen LO
  type: Person
  first name: Lars-Owe
  last name: Koskinen

index: 102
item: Kovács N
  type: Person
  first name: Noémi
  last name: Kovács

index: 103
item: Kowark A
  type: Person
  first name: Ana
  last name: Kowark

index: 104
item: Lagares A
  type: Person
  first name: Alfonso
  last name: Lagares

index: 105
item: Lanyon L
  type: Person
  first name: Linda
  last name: Lanyon

index: 106
item: Laureys S
  type: Person
  first name: Steven
  last name: Laureys

index: 107
item: Lecky F
  type: Person
  first name: Fiona
  last name: Lecky

index: 108
item: Ledoux D
  type: Person
  first name: Didier
  last name: Ledoux

index: 109
item: Lefering R
  type: Person
  first name: Rolf
  last name: Lefering

index: 110
item: Legrand V
  type: Person
  first name: Valerie
  last name: Legrand

index: 111
item: Lejeune A
  type: Person
  first name: Aurelie
  last name: Lejeune

index: 112
item: Levi L
  type: Person
  first name: Leon
  last name: Levi

index: 113
item: Lightfoot R
  type: Person
  first name: Roger
  last name: Lightfoot

index: 114
item: Lingsma H
  type: Person
  first name: Hester
  last name: Lingsma

index: 115
item: Maas AIR
  type: Person
  first name: Andrew I R
  last name: Maas

index: 116
item: Castaño-León AM
  type: Person
  first name: Ana M
  last name: Castaño-León

index: 117
item: Maegele M
  type: Person
  first name: Marc
  last name: Maegele

index: 118
item: Majdan M
  type: Person
  first name: Marek
  last name: Majdan

index: 119
item: Manara A
  type: Person
  first name: Alex
  last name: Manara

index: 120
item: Manley G
  type: Person
  first name: Geoffrey
  last name: Manley

index: 121
item: Martino C
  type: Person
  first name: Costanza
  last name: Martino

index: 122
item: Maréchal H
  type: Person
  first name: Hugues
  last name: Maréchal

index: 123
item: Mattern J
  type: Person
  first name: Julia
  last name: Mattern

index: 124
item: McMahon C
  type: Person
  first name: Catherine
  last name: McMahon

index: 125
item: Melegh B
  type: Person
  first name: Béla
  last name: Melegh

index: 126
item: Menon D
  type: Person
  first name: David
  last name: Menon

index: 127
item: Menovsky T
  type: Person
  first name: Tomas
  last name: Menovsky

index: 128
item: Mikolic A
  type: Person
  first name: Ana
  last name: Mikolic

index: 129
item: Misset B
  type: Person
  first name: Benoit
  last name: Misset

index: 130
item: Muraleedharan V
  type: Person
  first name: Visakh
  last name: Muraleedharan

index: 131
item: Murray L
  type: Person
  first name: Lynnette
  last name: Murray

index: 132
item: Negru A
  type: Person
  first name: Ancuta
  last name: Negru

index: 133
item: Nelson D
  type: Person
  first name: David
  last name: Nelson

index: 134
item: Newcombe V
  type: Person
  first name: Virginia
  last name: Newcombe

index: 135
item: Nieboer D
  type: Person
  first name: Daan
  last name: Nieboer

index: 136
item: Nyirádi J
  type: Person
  first name: József
  last name: Nyirádi

index: 137
item: Olubukola O
  type: Person
  first name: Otesile
  last name: Olubukola

index: 138
item: Oresic M
  type: Person
  first name: Matej
  last name: Oresic

index: 139
item: Ortolano F
  type: Person
  first name: Fabrizio
  last name: Ortolano

index: 140
item: Palotie A
  type: Person
  first name: Aarno
  last name: Palotie

index: 141
item: Parizel PM
  type: Person
  first name: Paul M
  last name: Parizel

index: 142
item: Payen JF
  type: Person
  first name: Jean-François
  last name: Payen

index: 143
item: Perera N
  type: Person
  first name: Natascha
  last name: Perera

index: 144
item: Perlbarg V
  type: Person
  first name: Vincent
  last name: Perlbarg

index: 145
item: Persona P
  type: Person
  first name: Paolo
  last name: Persona

index: 146
item: Peul W
  type: Person
  first name: Wilco
  last name: Peul

index: 147
item: Piippo-Karjalainen A
  type: Person
  first name: Anna
  last name: Piippo-Karjalainen

index: 148
item: Pirinen M
  type: Person
  first name: Matti
  last name: Pirinen

index: 149
item: Pisica D
  type: Person
  first name: Dana
  last name: Pisica

index: 150
item: Ples H
  type: Person
  first name: Horia
  last name: Ples

index: 151
item: Polinder S
  type: Person
  first name: Suzanne
  last name: Polinder

index: 152
item: Pomposo I
  type: Person
  first name: Inigo
  last name: Pomposo

index: 153
item: Posti JP
  type: Person
  first name: Jussi P
  last name: Posti

index: 154
item: Puybasset L
  type: Person
  first name: Louis
  last name: Puybasset

index: 155
item: Radoi A
  type: Person
  first name: Andreea
  last name: Radoi

index: 156
item: Ragauskas A
  type: Person
  first name: Arminas
  last name: Ragauskas

index: 157
item: Raj R
  type: Person
  first name: Rahul
  last name: Raj

index: 158
item: Rambadagalla M
  type: Person
  first name: Malinka
  last name: Rambadagalla

index: 159
item: Helmrich IR
  type: Person
  first name: Isabel Retel
  last name: Helmrich

index: 160
item: Rhodes J
  type: Person
  first name: Jonathan
  last name: Rhodes

index: 161
item: Richardson S
  type: Person
  first name: Sylvia
  last name: Richardson

index: 162
item: Richter S
  type: Person
  first name: Sophie
  last name: Richter

index: 163
item: Ripatti S
  type: Person
  first name: Samuli
  last name: Ripatti

index: 164
item: Rocka S
  type: Person
  first name: Saulius
  last name: Rocka

index: 165
item: Roe C
  type: Person
  first name: Cecilie
  last name: Roe

index: 166
item: Roise O
  type: Person
  first name: Olav
  last name: Roise

index: 167
item: Rosand J
  type: Person
  first name: Jonathan
  last name: Rosand

index: 168
item: Rosenfeld JV
  type: Person
  first name: Jeffrey V
  last name: Rosenfeld

index: 169
item: Rosenlund C
  type: Person
  first name: Christina
  last name: Rosenlund

index: 170
item: Rosenthal G
  type: Person
  first name: Guy
  last name: Rosenthal

index: 171
item: Rossaint R
  type: Person
  first name: Rolf
  last name: Rossaint

index: 172
item: Rossi S
  type: Person
  first name: Sandra
  last name: Rossi