Stem-cell biology: a move in the right direction.
pmid: 17108968
has PII: nature05406
doi: 10.1038/nature05406
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Chamberlain JS
      type: Person
      first name: Jeffrey S
      last name: Chamberlain
created: 2006-11-17T09:00
date last updated: 2025-01-20
issued: 2006-11-30
dp: 2006 Nov 30
e ISSN: 1476-4687
has issn l: 0028-0836
issue: 7119
has NLM journal title abbreviation: Nature
publication name: Nature
language: eng
has national library of medicine journal id: 0410462
derived from: NLM
starting page: 552
ending page: 3
has place of publication: England
has primary subject term: D020388Q000628
has primary subject term: D033581
has subject term: D053687Q000637
has subject term: D000818
has subject term: D003131
has subject term: D004285
has subject term: D016189Q000235
has subject term: D015316
has subject term: D006801
source: Nature. 2006-11-30;444(7119):552-3.
volume: 444

[Renal insufficiency in the context of cardio-pulmonary-renal pathophysiology].
pmid: 34605971
abstract: Heart failure and renal insufficiency as well as pulmonary hypertension are pathophysiologically closely associated as a cardio-renal or cardio-pulmonary-renal syndrome. Due to the frequent hospitalization of patients affected by this syndrome, it is of high medical and also health economic relevance. Besides the inhibition of the renin-angiotensin-aldosterone system (RAAS), multimodal treatment options are available with mineralocorticoid receptor antagonists, angiotensin receptor-neprilysin inhibitors and sodium-glucose transporter 2 (SGLT-2) inhibitors. Profound knowledge of the pathophysiology and the therapeutic options is as necessary for an optimized medical care as patient-oriented, transdisciplinary and cross-sectoral care.
rights: © 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
has PII: 10.1007/s00108-021-01170-2
doi: 10.1007/s00108-021-01170-2
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Schwenger V
      type: Person
      first name: Vedat
      last name: Schwenger
      member of: Klinik für Nieren‑, Hochdruck- und Autoimmunerkrankungen, Klinikum der Landeshauptstadt Stuttgart gKAöR, Katharinenhospital, Kriegsbergstr. 60, 70174, Stuttgart, Deutschland. sekretariat.schwenger@klinikum-stuttgart.de.
  slot:
    index: 2
    item: Emrich IE
      type: Person
      first name: Insa E
      last name: Emrich
      member of: Klinik für Innere Medizin III - Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Deutschland.
  slot:
    index: 3
    item: Mahfoud F
      type: Person
      first name: Felix
      last name: Mahfoud
      member of: Klinik für Innere Medizin III - Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Deutschland.
  slot:
    index: 4
    item: Latus J
      type: Person
      first name: Jörg
      last name: Latus
      member of: Klinik für Nieren‑, Hochdruck- und Autoimmunerkrankungen, Klinikum der Landeshauptstadt Stuttgart gKAöR, Katharinenhospital, Kriegsbergstr. 60, 70174, Stuttgart, Deutschland.
  slot:
    index: 5
    item: Remppis A
      type: Person
      first name: Andrew
      last name: Remppis
      member of: Klinik für Kardiologie, Herz- und Gefäßzentrum Bad Bevensen, Bad Bevensen, Deutschland.
created: 2021-10-5T06:00
date last updated: 2025-01-20
issued: 2021-11
dp: 2021 Nov
created: 2021-10-4T12:25
e ISSN: 1432-1289
has issn l: 0020-9554
issue: 11
has NLM journal title abbreviation: Internist (Berl)
publication name: Der Internist
language: ger
has national library of medicine journal id: 0264620
rights holder: Herzinsuffizienz und Niereninsuffizienz sowie pulmonale Hypertonie sind als kardiorenales oder kardiopulmorenales Syndrom pathophysiologisch eng miteinander verzahnt. Aufgrund der häufigen Hospitalisierung der hiervon betroffenen Patienten kommt diesem Syndrom eine hohe medizinische, aber auch gesundheitsökonomische Relevanz zu. Neben der Blockade des Renin-Angiotensin-Aldosteron-Systems stehen mit den Mineralokortikoidrezeptorantagonisten, Angiotensinrezeptor-Neprilysin-Inhibitoren sowie Natrium-Glukose-Kotransporter-2(SGLT-2)-Inhibitoren multimodale Therapiemöglichkeiten zur Verfügung. Die Kenntnis der pathophysiologischen Grundlagen und der therapeutischen Optionen ist für eine optimierte medizinische Betreuung genauso notwendig wie eine patientenorientierte, transdisziplinäre und sektorenübergreifende Versorgung.
derived from: NLM
starting page: 1153
ending page: 1165
has place of publication: Germany
has primary subject term: D006333Q000175Q000628
has primary subject term: D051437Q000628
has subject term: D057911
has subject term: D006801
has subject term: D000451Q000627
has subject term: D012084
has subject term: D013318
source: Internist (Berl). 2021-11;62(11):1153-1165.
volume: 62

Energy cost assessment of a dairy industry wastewater treatment plant.
pmid: 32696135
abstract: Water and energy are closely interlinked during their production and consumption processes. The limited and temporary distribution of energy and water resources poses a significant environmental challenge. Industrial wastewater treatment plants are essential elements of water production and also significant energy consumers. This study proposes a methodology for energy management of a wastewater treatment plant. Specifically, it examines the impact of optimum operating conditions on energy costs for a dairy wastewater treatment plant using a dissolved air flotation process. Monte Carlo simulation was used to optimize the parameters and to determine the reuse potential of dairy effluent. Firstly, the optimum operating conditions were determined. The results revealed a maximum fat, oil, and grease removal efficiency of 97% and a chemical oxygen demand removal efficiency of 70%. The optimum conditions were pH of 8, a saturation pressure of 5 bars, and a recirculation ratio of 33%. The optimum concentrations of coagulant and flocculant that contain polyaluminum chloride and cationic polymer were 20 mg/L and 25 mg/L, respectively. The results of the simulation study gave a recirculation ratio of 26.31%, a polyaluminum chloride concentration of 42.5 mg/L, a cationic polymer concentration of 36.31 mg/L, and a saturation pressure of 4.61 bars. Finally, energy cost assessment was performed using a newly developed model which showed that the energy cost indicator of the existing process was lower than optimum operating conditions. The reuse potential of dairy effluent as cooling water was found to be 52%.
has PII: 10.1007/s10661-020-08492-y
doi: 10.1007/s10661-020-08492-y
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Yapıcıoğlu P
      type: Person
      first name: Pelin
      last name: Yapıcıoğlu
      member of: Environmental Engineering Department, Engineering Faculty, Harran University, Sanliurfa, Turkey.
  slot:
    index: 2
    item: Yeşilnacar MI
      type: Person
      first name: Mehmet Irfan
      last name: Yeşilnacar
      member of: Environmental Engineering Department, Engineering Faculty, Harran University, Sanliurfa, Turkey. iyesilnacar@gmail.com.
created: 2020-7-23T06:00
date last updated: 2025-01-20
issued: 2020-07-21
dp: 2020 Jul 21
e ISSN: 1573-2959
has issn l: 0167-6369
issue: 8
has NLM journal title abbreviation: Environ Monit Assess
publication name: Environmental monitoring and assessment
language: eng
has national library of medicine journal id: 8508350
derived from: NLM
pg: 536
has place of publication: Netherlands
has primary subject term: D014865
has primary subject term: D062065
has subject term: D057919
has subject term: D003612
has subject term: D004784
source: Environ Monit Assess. 2020-07-21;192(8):536.
volume: 192

Correction to: Characterization of the Cerebrospinal Fluid Proteome in Patients with Fragile X-Associated Tremor/Ataxia Syndrome.
pmid: 34505966
has PII: 10.1007/s12311-021-01321-z
doi: 10.1007/s12311-021-01321-z
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Abbasi DA
      type: Person
      first name: Diana A
      last name: Abbasi
      member of: Department of Pediatrics and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  slot:
    index: 2
    item: Nguyen TTA
      type: Person
      first name: Thu T A
      last name: Nguyen
      member of: Department of Chemistry, University of Illinois At Chicago, Chicago, IL, USA.
  slot:
    index: 3
    item: Hall DA
      type: Person
      first name: Deborah A
      last name: Hall
      member of: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  slot:
    index: 4
    item: Robertson-Dick E
      type: Person
      first name: Erin
      last name: Robertson-Dick
      member of: Department of Communication Sciences and Disorders, Northwestern University, Chicago, IL, USA.
  slot:
    index: 5
    item: Berry-Kravis E
      type: Person
      first name: Elizabeth
      last name: Berry-Kravis
      member of: Department of Pediatrics and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  slot:
    index: 6
    item: Cologna SM
      type: Person
      first name: Stephanie M
      last name: Cologna
      member of: Department of Chemistry, University of Illinois At Chicago, Chicago, IL, USA. cologna@uic.edu.Laboratory of Integrated Neuroscience, University of Illinois At Chicago, 845 W Taylor Street, Room 4500, Chicago, IL, 60607, USA. cologna@uic.edu.
created: 2021-9-11T06:00
date last updated: 2025-01-20
issued: 2022-02
dp: 2022 Feb
created: 2021-9-10T12:17
e ISSN: 1473-4230
has issn l: 1473-4222
issue: 1
has NLM journal title abbreviation: Cerebellum
publication name: Cerebellum (London, England)
language: eng
has national library of medicine journal id: 101089443
derived from: NLM
starting page: 99
ending page: 100
has place of publication: United States
source: Cerebellum. 2022-02;21(1):99-100.
volume: 21

Fetal head and neck tumors.
pmid: 33252765
abstract: Imaging plays a leading role in detection and diagnosis of fetal head and neck lesions. These lesions comprise a heterogeneous group of congenital tumors and malformations. Complementary imaging modalities that can be used in prenatal medicine are ultrasound and MRI. The authors discuss imaging characteristics of fetal lesions, assessment of potential complications and pregnancy management options for the most common pathology of the fetal head and neck.
has PII: 10.1007/s00247-020-04757-3
doi: 10.1007/s00247-020-04757-3
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Feygin T
      type: Person
      first name: Tamara
      last name: Feygin
      member of: Department of Neuroradiology, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA, USA. feygin@email.chop.edu.
  slot:
    index: 2
    item: Bilaniuk LT
      type: Person
      first name: Larissa T
      last name: Bilaniuk
      member of: Department of Neuroradiology, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA, USA.
created: 2020-12-1T06:00
date last updated: 2025-01-20
issued: 2020-12
dp: 2020 12
created: 2020-11-30T12:12
e ISSN: 1432-1998
has issn l: 0301-0449
issue: 13
has NLM journal title abbreviation: Pediatr Radiol
publication name: Pediatric radiology
language: eng
has national library of medicine journal id: 0365332
derived from: NLM
starting page: 1999
ending page: 2008
has place of publication: Germany
has primary subject term: D006258Q000000981
has primary subject term: D011296
has subject term: D005260
has subject term: D005333Q000000981
has subject term: D006257
has subject term: D006801
has subject term: D008279
has subject term: D011247
has subject term: D016216
source: Pediatr Radiol. 2020-12;50(13):1999-2008.
volume: 50

Effects of green light photobiomodulation on Dental Pulp Stem Cells: enhanced proliferation and improved wound healing by cytoskeleton reorganization and cell softening.
pmid: 32621128
abstract: Photobiomodulation (PBM) has been shown to improve cell proliferation and cell migration. Many cell types have been investigated, with most studies using deep penetrating red light irradiation. Considering the interest of surface biostimulation of oral mesenchymal cells after surgical wound, the present study aimed to assess green light irradiation effects on Dental Pulp Stem Cells' (DPSC) proliferation and migration. To understand the mechanisms underlying these effects, we investigated cytoskeleton organization and subsequent cell shape and stiffness. A 532-nm wavelength Nd:YAG laser (30 mW) was applied between 30 and 600 s on DPSC in vitro. Cell proliferation was analyzed at 24, 48, and 72 h after irradiation, by cell counting and enzymatic activity quantification (paranitrophenylphosphate phosphatase (pNPP) test). A wound healing assay was used to study cell migration after irradiation. Effects of PBM on cytoskeleton organization and cell shape were assessed by actin filaments staining. Elasticity changes after irradiation were quantified in terms of Young's modulus measured using Atomic Force Microscopy (AFM) force spectroscopy. Green light significantly improved DPSC proliferation with a maximal effect obtained after 300-s irradiation (energy fluence 5 J/cm2). This irradiation had a significant impact on cell migration, improving wound healing after 24 h. These results were concomitant with a decrease of cells' Young's modulus after irradiation. This cell softening was explained by actin cytoskeleton reorganization, with diminution of cell circularity and more abundant pseudopodia. This study highlights the interest of green laser PMB for the proliferation and migration of mesenchymal stem cells, with encouraging results for clinical application, especially for surgical wound healing procedures.
has PII: 10.1007/s10103-020-03092-1
doi: 10.1007/s10103-020-03092-1
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Malthiery E
      type: Person
      first name: Eve
      last name: Malthiery
      member of: LBN, University Montpellier, 545 Av Pr JL Viala, 34193 CEDEX 4, Montpellier, France.
  slot:
    index: 2
    item: Chouaib B
      type: Person
      first name: Batoul
      last name: Chouaib
      member of: LBN, University Montpellier, 545 Av Pr JL Viala, 34193 CEDEX 4, Montpellier, France.
  slot:
    index: 3
    item: Hernandez-Lopez AM
      type: Person
      first name: Ana María
      last name: Hernandez-Lopez
      member of: LBN, University Montpellier, 545 Av Pr JL Viala, 34193 CEDEX 4, Montpellier, France.Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Mexico.
  slot:
    index: 4
    item: Martin M
      type: Person
      first name: Marta
      last name: Martin
      member of: L2C, CNRS, University Montpellier, Montpellier, France.
  slot:
    index: 5
    item: Gergely C
      type: Person
      first name: Csilla
      last name: Gergely
      member of: L2C, CNRS, University Montpellier, Montpellier, France.
  slot:
    index: 6
    item: Torres JH
      type: Person
      first name: Jacques-Henri
      last name: Torres
      member of: LBN, University Montpellier, 545 Av Pr JL Viala, 34193 CEDEX 4, Montpellier, France.
  slot:
    index: 7
    item: Cuisinier FJ
      type: Person
      first name: Frédéric J
      last name: Cuisinier
      member of: LBN, University Montpellier, 545 Av Pr JL Viala, 34193 CEDEX 4, Montpellier, France.
  slot:
    index: 8
    item: Collart-Dutilleul PY
      type: Person
      first name: Pierre-Yves
      last name: Collart-Dutilleul
      member of: LBN, University Montpellier, 545 Av Pr JL Viala, 34193 CEDEX 4, Montpellier, France. pierre-yves.collart-dutilleul@umontpellier.fr.
created: 2020-7-6T06:00
date last updated: 2025-01-20
issued: 2021-03
dp: 2021 Mar
created: 2020-7-5T06:00
e ISSN: 1435-604X
has issn l: 0268-8921
issue: 2
has NLM journal title abbreviation: Lasers Med Sci
publication name: Lasers in medical science
language: eng
has national library of medicine journal id: 8611515
derived from: NLM
starting page: 437
ending page: 445
has place of publication: England
has primary subject term: D003599Q000528
has primary subject term: D003782Q000166
has primary subject term: D028022
has primary subject term: D059630Q000166Q000528
has primary subject term: D014945Q000528
has subject term: D000293
has subject term: D000328
has subject term: D001696Q000528
has subject term: D002465Q000528
has subject term: D049109Q000528
has subject term: D048430Q000528
has subject term: D002478
has subject term: D006801
has subject term: D055815
source: Lasers Med Sci. 2021-03;36(2):437-445.
volume: 36

Cost comparison of treatment for oropharyngeal carcinoma.
pmid: 30485445
abstract: Based on current guidelines, surgical and nonsurgical therapies are viable frontline treatment for patients with locoregional oropharyngeal carcinoma (OPC). We sought to compare financial parameters between chemoradiation and transoral robotic surgery (TORS) in this patient population.Case-control study.In this study we identified patients with selected American Joint Committee on Cancer 7th Edition stage II to IVa OPC treated with TORS between January 2013 and December 2014. Fifteen patients who underwent TORS were stage matched with 15 patients treated with chemoradiation. Total charges and cost data for each patient were analyzed at 4-month and 1-year time points; functional and oncologic outcomes were assessed.There were no significant differences in functional and oncologic outcomes. Patients undergoing TORS had a longer inpatient hospital stay, and most required a nasogastric tube for an average of 3.5 days. There were no local or regional recurrences. Across all time points, the TORS group had lower charges and costs compared to the chemoradiation group, with 14% lower costs at 1 year. In the chemoradiation group, nearly two-thirds of costs came from radiation therapy and pharmacy expenses. Chemotherapy accounted for most pharmacy costs. The costs of operating the surgical robot accounted for a about half of surgical costs.Selected patients with stage II to IVa oropharyngeal carcinoma treated with TORS may incur lower costs than those treated nonsurgically. With rising healthcare spending, the financial impact of treatment might be considered for those patients eligible for treatment regimens with comparable functional and oncologic outcomes.3b Laryngoscope, 129:1604-1609, 2019.
rights: © 2018 The American Laryngological, Rhinological and Otological Society, Inc.
doi: 10.1002/lary.27544
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Tam K
      type: Person
      first name: Kenric
      last name: Tam
      member of: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, U.S.A.
  slot:
    index: 2
    item: Orosco RK
      type: Person
      first name: Ryan K
      last name: Orosco
      member of: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, U.S.A.
  slot:
    index: 3
    item: Dimitrios Colevas A
      type: Person
      first name: A
      last name: Dimitrios Colevas
      member of: Department of Medicine, Division of Oncology, Stanford University School of Medicine, Palo Alto, California, U.S.A.
  slot:
    index: 4
    item: Bedi N
      type: Person
      first name: Nikita
      last name: Bedi
      member of: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, U.S.A.
  slot:
    index: 5
    item: Starmer HM
      type: Person
      first name: Heather M
      last name: Starmer
      member of: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, U.S.A.
  slot:
    index: 6
    item: Beadle BM
      type: Person
      first name: Beth M
      last name: Beadle
      member of: Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California, U.S.A.
  slot:
    index: 7
    item: Holsinger FC
      type: Person
      first name: F Christopher
      last name: Holsinger
      member of: Department of Otolaryngology, Division of Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, U.S.A.
created: 2018-11-30T06:00
date last updated: 2025-01-20
issued: 2019-07
dp: 2019 07
created: 2018-11-29T06:00
e ISSN: 1531-4995
has issn l: 0023-852X
issue: 7
has NLM journal title abbreviation: Laryngoscope
publication name: The Laryngoscope
language: eng
has national library of medicine journal id: 8607378
derived from: NLM
starting page: 1604
ending page: 1609
has place of publication: United States
has primary subject term: D059248Q000191
has primary subject term: D007441Q000191
has primary subject term: D009959Q000473Q000628
has primary subject term: D065287Q000191
has subject term: D016022
has subject term: D003365
has subject term: D005260
has subject term: D006801
has subject term: D007902Q000191
has subject term: D008297
has subject term: D008875
has subject term: D009367
source: Laryngoscope. 2019-07;129(7):1604-1609.
volume: 129

The expression level of COX7C associates with venous thromboembolism in colon cancer patients.
pmid: 32653968
abstract: Venous thromboembolism (VTE) is a common complication of colon cancer. In the present study, we aimed to explore the association of the oncogene COX7C to VTE in colon cancer patients. Samples from 580 patients were examined histologically for VTE and pathological characteristic of cancer. Gene mutation and expression analysis were performed using polymerase chain reaction-based assays to evaluate genes related to VTE, including COX7C. Univariate analysis between clinical pathological factors and VTE was conducted. Logistic regression analysis was performed for the prediction of VTE by pathological factors and gene expressions. Among patients investigated, a total of 56 patients had VTE. COX7C had a significant correlation with VTE (p < 0.001). Despite a correlation between tumor size, invasion depth of tumor, lymph node metastasis, lymph node metastasis, distant metastasis, lymphovascular invasion, histologic type and pathology type, Ki-67, and some other genes, to VTE (p > 0.05), only COX7C expression demonstrated significance in its ability to predict VTE. Here, we show that COX7C upregulation strongly correlates with VTE in colon cancer, which implicates its role as a biomarker and therapeutic target of VTE in colon cancer.
has PII: 10.1007/s10238-020-00644-1
doi: 10.1007/s10238-020-00644-1
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Wu B
      type: Person
      first name: Biyu
      last name: Wu
      member of: Department of Nursing, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
  slot:
    index: 2
    item: Chen S
      type: Person
      first name: Shurong
      last name: Chen
      member of: Department of Geriatric, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
  slot:
    index: 3
    item: Zhuang L
      type: Person
      first name: Lihong
      last name: Zhuang
      member of: Second Department of Gastrointestinal Surgery, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
  slot:
    index: 4
    item: Zeng J
      type: Person
      first name: Jingyang
      last name: Zeng
      member of: Department of Anesthesiology, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian, China. zengjingyang138168@163.com.
created: 2020-7-13T06:00
date last updated: 2025-01-20
issued: 2020-11
dp: 2020 Nov
e ISSN: 1591-9528
has issn l: 1591-8890
issue: 4
has NLM journal title abbreviation: Clin Exp Med
publication name: Clinical and experimental medicine
language: eng
has national library of medicine journal id: 100973405
derived from: NLM
starting page: 527
ending page: 533
has place of publication: Italy
has primary subject term: D003110Q000097Q000150Q000235Q000473
has primary subject term: D003576Q000097
has primary subject term: D009687Q000097
has primary subject term: D054556Q000097Q000453Q000209Q000235
has subject term: D000328
has subject term: D000368
has subject term: D015415Q000097
has subject term: D015972
has subject term: D006801
has subject term: D015994
has subject term: D016015
has subject term: D008875
has subject term: D009154
source: Clin Exp Med. 2020-11;20(4):527-533.
volume: 20

DNA vaccination with AFP-encoding plasmid DNA prevents growth of subcutaneous AFP-expressing tumors and does not interfere with liver regeneration in mice.
pmid: 11960285
abstract: The oncofetal alpha-fetoprotein (AFP) is reexpressed in the majority of hepatocellular carcinomas and may be used as a target molecule for an immunotherapy or prophylaxis against this tumor. We investigated the potential of DNA vaccination with AFP-expressing plasmid DNA to induce an immune response against AFP-expressing tumor cells in DBA/2 mice. 62.5% of mice vaccinated with AFP-expressing plasmid DNA, rejected subcutaneous syngeneic AFP-expressing P815 tumors, whereas only 16.7% of mice vaccinated with control plasmid rejected these tumor cells (P=.03). Mean survival of mice after challenge with subcutaneous AFP-expressing tumor cells was prolonged for 8 days in mice vaccinated with AFP-expressing DNA (35 days) compared to mice vaccinated with control plasmid (27 days). To rule out possible autoimmune reactions against regenerating liver, which also reexpresses AFP, we evaluated the influence of AFP-specific DNA vaccination on liver regeneration in DBA/2 mice. Histologic quantification of proliferating hepatocytes and of the amount of necrotic liver tissue in carbon tetrachloride-damaged liver did not reveal statistically significant differences in mice vaccinated with AFP-expressing plasmid compared to control mice. These data suggest that AFP-specific DNA vaccination represents a useful tool to inhibit growth of AFP-expressing tumors in mice that does not affect liver regeneration.
doi: 10.1038/sj.cgt.7700445
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hanke P
      type: Person
      first name: Petra
      last name: Hanke
      member of: Department of Medicine I, University of Bonn, Bonn, Germany.
  slot:
    index: 2
    item: Serwe M
      type: Person
      first name: Matthias
      last name: Serwe
  slot:
    index: 3
    item: Dombrowski F
      type: Person
      first name: Frank
      last name: Dombrowski
  slot:
    index: 4
    item: Sauerbruch T
      type: Person
      first name: Tilman
      last name: Sauerbruch
  slot:
    index: 5
    item: Caselmann WH
      type: Person
      first name: Wolfgang H
      last name: Caselmann
created: 2002-4-18T10:00
date last updated: 2025-01-20
issued: 2002-04
dp: 2002 Apr
ISSN: 0929-1903
has issn l: 0929-1903
issue: 4
has NLM journal title abbreviation: Cancer Gene Ther
publication name: Cancer gene therapy
language: eng
has national library of medicine journal id: 9432230
derived from: NLM
starting page: 346
ending page: 55
has place of publication: England
has primary subject term: D008114Q000276Q000517
has primary subject term: D008115Q000502
has primary subject term: D014611Q000379
has primary subject term: D019444Q000627
has primary subject term: D000509Q000235Q000378
has subject term: D000818
has subject term: D001973
has subject term: D015316
has subject term: D007279
has subject term: D008213Q000276
has subject term: D008214Q000276
has subject term: D051379
has subject term: D008807
has subject term: D008811
has subject term: D016513
has subject term: D010957Q000235
has subject term: D014162
has subject term: D014407
source: Cancer Gene Ther. 2002-04;9(4):346-55.
volume: 9

Proteome profile of spleen in rock bream (Oplegnathus fasciatus) naturally infected with rock bream iridovirus (RBIV).
pmid: 34427872
abstract: Rock bream iridovirus (RBIV) is one of the most dangerous pathogens that causes the highest mortality in the aquaculture of rock bream (Oplegnathus fasciatus). Even though RBIV infection leads to huge economic loss, proteome studies on RBIV-infected rock bream have not been conducted to provide information about the differential protein expression pattern by the host protection system.The purpose of this study was to investigate the protein expression patterns in spleens of rock bream olive after infection by RBIV or mixed infection by RBIV and bacteria.Depending on the infection intensity and sampling time point, fish were divided into five groups: uninfected healthy fish at week 0 as the control (0C), heavily infected fish at week 0 (0H), heavily mixed RBIV and bacterial infected fish at week 0 (0MH), uninfected healthy fish at week 3 (3C), and lightly infected fish at week 3 (3L). Proteins were extracted from the spleens of infected rock bream. We used 2-DE analysis with LC-MS/MS to investigate proteome changes in infected rock bream.The results of the LC-MS/MS analyses showed different protein expression profiles after infection. Proteins related to oxygen transport and energy generation, such as hemoglobin, beta-globin, and ATP synthase, were mostly expressed in the infected spleen. Whereas proteins involved in structure and cell movement, such as tubulin, myosin, actin binding proteins, and intermediate filament proteins, were down-regulated in the infected spleens. The protein expression profiles between infection by RBIV and mixed infection by RBIV and bacteria showed similar patterns.Our results indicated that infection by RBIV or mixed infection by RBIV and bacteria triggered energy generation and oxygen-transport, but cell migration and constructional changes in the spleen were extremely decreased.
rights: © 2021. The Genetics Society of Korea.
has PII: 10.1007/s13258-021-01149-1
doi: 10.1007/s13258-021-01149-1
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Ko EJ
      type: Person
      first name: Eun-Ji
      last name: Ko
      member of: Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea.
  slot:
    index: 2
    item: Kim H
      type: Person
      first name: Hyunsu
      last name: Kim
      member of: Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea.
  slot:
    index: 3
    item: Lee AR
      type: Person
      first name: A-Reum
      last name: Lee
      member of: Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea.
  slot:
    index: 4
    item: Jeon KY
      type: Person
      first name: Kyung-Yoon
      last name: Jeon
      member of: Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea.
  slot:
    index: 5
    item: Kim A
      type: Person
      first name: Ahran
      last name: Kim
      member of: Pathology Research Division, National Institute of Fisheries Science, Busan, Republic of Korea.
  slot:
    index: 6
    item: Kim DH
      type: Person
      first name: Do-Hyung
      last name: Kim
      member of: Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, Busan, Republic of Korea.
  slot:
    index: 7
    item: Park CI
      type: Person
      first name: Chan-Il
      last name: Park
      member of: Department of Marine Biology and Aquaculture, College of Marine Science, Gyeongsang National University, Tongyeong, Republic of Korea.
  slot:
    index: 8
    item: Choi YH
      type: Person
      first name: Yung Hyun
      last name: Choi
      member of: Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea.
  slot:
    index: 9
    item: Kim S
      type: Person
      first name: Suhkmann
      last name: Kim
      member of: Department of Chemistry, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.
  slot:
    index: 10
    item: Kim HS
      type: Person
      first name: Heui-Soo
      last name: Kim
      member of: Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.
  slot:
    index: 11
    item: Ock MS
      type: Person
      first name: Mee Sun
      last name: Ock
      member of: Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea.
  slot:
    index: 12
    item: Cha HJ
      type: Person
      first name: Hee-Jae
      last name: Cha
      member of: Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea. hcha@kosin.ac.kr.
created: 2021-8-25T06:00
date last updated: 2025-01-20
issued: 2021-11
dp: 2021 11
created: 2021-8-24T12:32
e ISSN: 2092-9293
has issn l: 1976-9571
issue: 11
has NLM journal title abbreviation: Genes Genomics
publication name: Genes & genomics
language: eng
has national library of medicine journal id: 101481027
derived from: NLM
starting page: 1259
ending page: 1268
has place of publication: Korea (South)
has primary subject term: D005393Q000235Q000382Q000821
has primary subject term: D005399
has primary subject term: D017994
has primary subject term: D020543
has primary subject term: D013154Q000378Q000382Q000821
has subject term: D000818
has subject term: D002853
has subject term: D010473
has subject term: D040901
has subject term: D053719
source: Genes Genomics. 2021-11;43(11):1259-1268.
volume: 43

The association of arterial stiffness and arterial calcification: the Rotterdam study.
pmid: 18172454
has PII: 1002315
doi: 10.1038/sj.jhh.1002315
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Odink AE
      type: Person
      first name: A E
      last name: Odink
  slot:
    index: 2
    item: Mattace-Raso FU
      type: Person
      first name: F U S
      last name: Mattace-Raso
  slot:
    index: 3
    item: van der Lugt A
      type: Person
      first name: A
      last name: van der Lugt
  slot:
    index: 4
    item: Hofman A
      type: Person
      first name: A
      last name: Hofman
  slot:
    index: 5
    item: Hunink MG
      type: Person
      first name: M G M
      last name: Hunink
  slot:
    index: 6
    item: Breteler MM
      type: Person
      first name: M M B
      last name: Breteler
  slot:
    index: 7
    item: Krestin GP
      type: Person
      first name: G P
      last name: Krestin
  slot:
    index: 8
    item: Witteman JC
      type: Person
      first name: J C M
      last name: Witteman
created: 2008-1-4T09:00
date last updated: 2025-01-20
issued: 2008-03
dp: 2008 Mar
ISSN: 0950-9240
has issn l: 0950-9240
issue: 3
has NLM journal title abbreviation: J Hum Hypertens
publication name: Journal of human hypertension
language: eng
has national library of medicine journal id: 8811625
derived from: NLM
starting page: 205
ending page: 7
has place of publication: England
has primary subject term: D001018Q000175Q000453
has primary subject term: D001161Q000175Q000453
has primary subject term: D002340Q000175Q000453
has subject term: D017677
has subject term: D000368
has subject term: D000369
has subject term: D001027
has subject term: D001794
has subject term: D017536Q000000981
has subject term: D015331
has subject term: D015897
has subject term: D005260
has subject term: D006339
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D009426Q000453
has subject term: D011187
has subject term: D011237
has subject term: D011673
has subject term: D015203
has subject term: D012307
has subject term: D017678
has subject term: D014463
source: J Hum Hypertens. 2008-03;22(3):205-7.
volume: 22

Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis.
pmid: 16547497
abstract: We have previously described hTDE1, the human homologue of the recently described TDE1/TMS family of proteins whose members have been identified in several species. Although a defined biochemical activity has yet to be assigned to TDE1/TMS family members, previous results point to the overexpression of family members in tumor cell lines or tissues. To define whether hTDE1 may directly impact on neoplastic transformation, we derived and characterized stable Rat-1 transfectants that constitutively express hTDE1 at the plasma membrane. Expression of hTDE1 in Rat-1 transfectants had a significant effect on cell contact inhibition in vitro as judged by a focus formation assay. In addition, by monitoring caspase-3 activity and Hoechst staining, we determined that hTDE1 overexpression partially protects cells from serum starvation- and etoposide-induced apoptosis. Finally, hTDE1 Rat-1-expressing clones accelerated the formation of tumors in a nude mouse assay. Our results suggest that hTDE1 contributes directly to oncogenesis in vivo that may in part be explained by its effect on apoptosis in vitro.
has PII: 1209488
doi: 10.1038/sj.onc.1209488
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Bossolasco M
      type: Person
      first name: M
      last name: Bossolasco
      member of: Centre de recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal, Montreal, Quebec, Canada.
  slot:
    index: 2
    item: Veillette F
      type: Person
      first name: F
      last name: Veillette
  slot:
    index: 3
    item: Bertrand R
      type: Person
      first name: R
      last name: Bertrand
  slot:
    index: 4
    item: Mes-Masson AM
      type: Person
      first name: A-M
      last name: Mes-Masson
created: 2006-3-21T09:00
date last updated: 2025-01-20
issued: 2006-08-03
dp: 2006 Aug 03
ISSN: 0950-9232
has issn l: 0950-9232
issue: 33
has NLM journal title abbreviation: Oncogene
publication name: Oncogene
language: eng
has national library of medicine journal id: 8711562
derived from: NLM
starting page: 4549
ending page: 58
has place of publication: England
has primary subject term: D017209
has primary subject term: D009363Q000502
has primary subject term: D011956Q000502
has subject term: D000818
has subject term: D000972Q000494
has subject term: D053148
has subject term: D020169Q000378
has subject term: D002462Q000378
has subject term: D002471
has subject term: D005047Q000494
has subject term: D006801
has subject term: D066298
has subject term: D008562
has subject term: D051379
has subject term: D008819
has subject term: D009368
has subject term: D010957Q000378
has subject term: D051381
has subject term: D014162
source: Oncogene. 2006-08-03;25(33):4549-58.
volume: 25

Fluorescein angiography as a primary guide for reduced-fluence photodynamic therapy for the treatment of chronic central serous chorioretinopathy.
pmid: 32274613
abstract: The aim of this study is to investigate the results of fluorescein angiography (FA)-guided reduced-fluence photodynamic therapy (PDT) in the treatment of chronic central serous chorioretinopathy (CSCR), with the hypothesis that indocyanine green angiography (ICGA) guidance is avoidable in some cases.This retrospective study includes a consecutive nonrandomized series of chronic CSCR cases. All eyes were examined with FA and the ones that had discrete active leakage areas or points had undergone reduced-fluence PDT.The study included 45 eyes of 41 patients with a mean age of 48.8 ± 10.7. The main duration of last chronic CSCR episode was 13.0 ± 11.9 months. Thirty-nine (86.7%) out of 45 consecutive eyes had active leakage area(s) on FA, which enabled them to be treated with PDT. Remaining six eyes had undergone ICGA examination and had received an ICGA-guided PDT. In FA-guided eyes, the mean BCVA improved from 0.44 ± 0.25 Snellen lines to 0.63 ± 0.32 lines in the last control visit (p < 0.001). Both central macular thickness and subfoveal choroidal thickness decreased significantly in treated eyes. Thirty-eight eyes (97.4%) in FA-guided group and six eyes (100.0%) in ICGA-guided group had total resorption of subretinal fluid.This study provides basis to support the hypothesis that FA-guided half-fluence PDT may be justified as an alternative method of treatment in appropriate cases of chronic CSCR without compromising the therapeutic success.
has PII: 10.1007/s10792-020-01350-3
doi: 10.1007/s10792-020-01350-3
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Koytak A
      type: Person
      first name: Arif
      last name: Koytak
      member of: Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey. akoytak@yahoo.com.
  slot:
    index: 2
    item: Bayraktar H
      type: Person
      first name: Havvanur
      last name: Bayraktar
      member of: Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
  slot:
    index: 3
    item: Ozdemir H
      type: Person
      first name: Hakan
      last name: Ozdemir
      member of: Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
created: 2020-4-11T06:00
date last updated: 2025-01-20
issued: 2020-07
dp: 2020 Jul
e ISSN: 1573-2630
has issn l: 0165-5701
issue: 7
has NLM journal title abbreviation: Int Ophthalmol
publication name: International ophthalmology
language: eng
has national library of medicine journal id: 7904294
derived from: NLM
starting page: 1807
ending page: 1813
has place of publication: Netherlands
has primary subject term: D056833Q000175Q000188
has primary subject term: D005451
has primary subject term: D010778
has primary subject term: D011166
has subject term: D002908
has subject term: D006801
has subject term: D017319Q000627
has subject term: D012189
has subject term: D041623
has subject term: http://id.nlm.nih.gov/mesh/D000077362
source: Int Ophthalmol. 2020-07;40(7):1807-1813.
volume: 40

Dopamine and diet-induced obesity.
pmid: 30559474
has PII: 10.1038/s41593-018-0304-0
doi: 10.1038/s41593-018-0304-0
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: DiFeliceantonio AG
      type: Person
      first name: Alexandra G
      last name: DiFeliceantonio
      member of: Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.Modern Diet and PhysiologyResearch Center, YaleUniversity, New Haven, CT, USA.Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  slot:
    index: 2
    item: Small DM
      type: Person
      first name: Dana M
      last name: Small
      member of: Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. dana.small@yale.edu.Modern Diet and PhysiologyResearch Center, YaleUniversity, New Haven, CT, USA. dana.small@yale.edu.Department of Psychology, Yale University, New Haven, CT, USA. dana.small@yale.edu.
created: 2018-12-19T06:00
date last updated: 2025-01-20
issued: 2019-01
dp: 2019 01
e ISSN: 1546-1726
has issn l: 1097-6256
issue: 1
has NLM journal title abbreviation: Nat Neurosci
publication name: Nature neuroscience
language: eng
has national library of medicine journal id: 9809671
derived from: NLM
starting page: 1
ending page: 2
has place of publication: United States
has primary subject term: D004298
has primary subject term: http://id.nlm.nih.gov/mesh/D000073932
has subject term: D000818
has subject term: D004032
has subject term: D009765
has subject term: D051381
has subject term: D017448
has subject term: D012201
source: Nat Neurosci. 2019-01;22(1):1-2.
volume: 22

Esophageal perforation in very low birth weight infants.
pmid: 33410940
abstract: We aimed to assess the prevalence and outcomes of esophageal perforation in very low birth weight infants. This retrospective cohort study utilized the US National Inpatient Sample dataset for the years 2000 to 2017. A total of 1,755,418 very low birth weight infants were included; of them, 861 (0.05%) were diagnosed with esophageal perforation. The majority (77.9%) of infants were in the birth weight category < 1000 g and 77.7% in infants ≤ 28 weeks of gestation. The majority (73%) of infants were tracheally intubated and received mechanical ventilation; of them, 24 infants (2.8%) had tracheostomy. Mortality associated with esophageal perforation was 25.8%. Regression analysis did not show an association between esophageal perforation and increased mortality in preterm infants (aOR = 1.0, CI: 0.83-1.20, p = 0.991). Procedures encountered in these infants include thoracentesis (10.8%), laparotomy (4.1%), percutaneous abdominal drainage (4.1%), and gastrostomy tube insertion (6.2%), whereas the rest of the infants were managed conservatively. There was a significant trend for increasing prevalence of esophageal perforation over the years.Conclusion: Esophageal perforation does not independently increase the risk for mortality in very low birth weight infants. The increasing prevalence is possibly related to increased care offered to infants at limits of viability in recent years. What is Known: • Knowledge about esophageal perforation is derived from anecdotal single-center case reports. • Esophageal perforation in neonates is mostly iatrogenic. • It is considered a critical complication that is associated with high mortality. What is New: • This is the first and largest national study on prevalence of esophageal perforation in preterm infants. • Esophageal perforation does not independently increase the risk for mortality. • Septicemia and pneumothorax are frequent complications to esophageal perforation.
has PII: 10.1007/s00431-020-03894-z
doi: 10.1007/s00431-020-03894-z
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Elgendy MM
      type: Person
      first name: Marwa M
      last name: Elgendy
      member of: Department of Neonatology, Cleveland Clinic Children's, 900 Euclid Avenue, M31-37, Cleveland, OH, 44195, USA. elgendm@ccf.org.
  slot:
    index: 2
    item: Othman H
      type: Person
      first name: Hasan
      last name: Othman
      member of: Department of Pediatrics, Michigan State University/Sparrow Health System, Lansing, MI, USA.
  slot:
    index: 3
    item: Aly H
      type: Person
      first name: Hany
      last name: Aly
      member of: Department of Neonatology, Cleveland Clinic Children's, 900 Euclid Avenue, M31-37, Cleveland, OH, 44195, USA.
created: 2021-1-8T06:00
date last updated: 2025-01-20
issued: 2021-02
dp: 2021 Feb
created: 2021-1-7T12:16
e ISSN: 1432-1076
has issn l: 0340-6199
issue: 2
has NLM journal title abbreviation: Eur J Pediatr
publication name: European journal of pediatrics
language: eng
has national library of medicine journal id: 7603873
derived from: NLM
starting page: 513
ending page: 518
has place of publication: Germany
has primary subject term: D004939Q000453Q000209
has subject term: D005774
has subject term: D006801
has subject term: D007231
has subject term: D007234
has subject term: D019102
has subject term: D012189
source: Eur J Pediatr. 2021-02;180(2):513-518.
volume: 180

Improving data quality in observational research studies: Report of the Cure Glomerulonephropathy (CureGN) network.
pmid: 33851061
abstract: High data quality is of crucial importance to the integrity of research projects. In the conduct of multi-center observational cohort studies with increasing types and quantities of data, maintaining data quality is challenging, with few published guidelines.The Cure Glomerulonephropathy (CureGN) Network has established numerous quality control procedures to manage the 70 participating sites in the United States, Canada, and Europe. This effort is supported and guided by the activities of several committees, including Data Quality, Recruitment and Retention, and Central Review, that work in tandem with the Data Coordinating Center to monitor the study. We have implemented coordinator training and feedback channels, data queries of questionable or missing data, and developed performance metrics for recruitment, retention, visit completion, data entry, recording of patient-reported outcomes, collection, shipping and accessing of biological samples and pathology materials, and processing, cataloging and accessing genetic data and materials.We describe the development of data queries and site Report Cards, and their use in monitoring and encouraging excellence in site performance. We demonstrate improvements in data quality and completeness over 4 years after implementing these activities. We describe quality initiatives addressing specific challenges in collecting and cataloging whole slide images and other kidney pathology data, and novel methods of data quality assessment.This paper reports the CureGN experience in optimizing data quality and underscores the importance of general and study-specific data quality initiatives to maintain excellence in the research measures of a multi-center observational study.
rights: © 2021 Published by Elsevier Inc.
has PII: S2451-8654(21)00051-X
doi: 10.1016/j.conctc.2021.100749
creator: OrderedList
  length: 23
  slot:
    index: 1
    item: Gillespie BW
      type: Person
      first name: Brenda W
      last name: Gillespie
      member of: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
  slot:
    index: 2
    item: Laurin LP
      type: Person
      first name: Louis-Philippe
      last name: Laurin
      member of: Division of Nephrology, Maisonneuve-Rosemont Hospital, Department of Medicine, University of Montreal, Montreal, Quebec, Canada.
  slot:
    index: 3
    item: Zinsser D
      type: Person
      first name: Dawn
      last name: Zinsser
      member of: Arbor Research Collaborative for Health, Ann Arbor, MI, 48104, USA.
  slot:
    index: 4
    item: Lafayette R
      type: Person
      first name: Richard
      last name: Lafayette
      member of: Stanford University Medical Center, Stanford, CA, 94305, USA.
  slot:
    index: 5
    item: Marasa M
      type: Person
      first name: Maddalena
      last name: Marasa
      member of: Department of Medicine, Division of Nephrology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  slot:
    index: 6
    item: Wenderfer SE
      type: Person
      first name: Scott E
      last name: Wenderfer
      member of: Pediatrics-Renal, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 7
    item: Vento S
      type: Person
      first name: Suzanne
      last name: Vento
      member of: NYU Langone Health, Department of Pediatrics, Division of Nephrology, New York, NY, USA.
  slot:
    index: 8
    item: Poulton C
      type: Person
      first name: Caroline
      last name: Poulton
      member of: Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  slot:
    index: 9
    item: Barisoni L
      type: Person
      first name: Laura
      last name: Barisoni
      member of: Department of Pathology, Division of AI and Computational Pathology, Department of Medicine, Division of Nephrology, Duke University, Durham, NC, USA.
  slot:
    index: 10
    item: Zee J
      type: Person
      first name: Jarcy
      last name: Zee
      member of: Arbor Research Collaborative for Health, Ann Arbor, MI, 48104, USA.
  slot:
    index: 11
    item: Helmuth M
      type: Person
      first name: Margaret
      last name: Helmuth
      member of: Arbor Research Collaborative for Health, Ann Arbor, MI, 48104, USA.
  slot:
    index: 12
    item: Lugani F
      type: Person
      first name: Francesca
      last name: Lugani
      member of: Laboratory of Molecular Nephrology, Istituto Giannina Gaslini, IRCCS, Genoa, Italy.
  slot:
    index: 13
    item: Kamel M
      type: Person
      first name: Margret
      last name: Kamel
      member of: Emory University, Department of Pediatrics, Division of Nephrology, Atlanta, GA, USA.
  slot:
    index: 14
    item: Hill-Callahan P
      type: Person
      first name: Peg
      last name: Hill-Callahan
      member of: Arbor Research Collaborative for Health, Ann Arbor, MI, 48104, USA.
  slot:
    index: 15
    item: Hewitt SM
      type: Person
      first name: Stephen M
      last name: Hewitt
      member of: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  slot:
    index: 16
    item: Mariani LH
      type: Person
      first name: Laura H
      last name: Mariani
      member of: University of Michigan, Division of Nephrology, Ann Arbor, MI, USA.
  slot:
    index: 17
    item: Smoyer WE
      type: Person
      first name: William E
      last name: Smoyer
      member of: Center for Clinical and Translational Research, the Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
  slot:
    index: 18
    item: Greenbaum LA
      type: Person
      first name: Larry A
      last name: Greenbaum
      member of: Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.
  slot:
    index: 19
    item: Gipson DS
      type: Person
      first name: Debbie S
      last name: Gipson
      member of: University of Michigan, Division of Nephrology, Department of Pediatrics, Ann Arbor, MI, USA.
  slot:
    index: 20
    item: Robinson BM
      type: Person
      first name: Bruce M
      last name: Robinson
      member of: Arbor Research Collaborative for Health, Ann Arbor, MI, USA.
  slot:
    index: 21
    item: Gharavi AG
      type: Person
      first name: Ali G
      last name: Gharavi
      member of: Department of Medicine, Division of Nephrology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  slot:
    index: 22
    item: Guay-Woodford LM
      type: Person
      first name: Lisa M
      last name: Guay-Woodford
      member of: Center for Translational Research, Children's National Hospital, Washington, DC, USA.
  slot:
    index: 23
    item: Trachtman H
      type: Person
      first name: Howard
      last name: Trachtman
      member of: NYU Langone Health, Department of Pediatrics, Division of Nephrology, New York, NY, USA.
created: 2021-4-15T06:00
date last updated: 2025-01-20
issued: 2021-06
dp: 2021 Jun
created: 2021-4-14T06:37
e ISSN: 2451-8654
has issn l: 2451-8654
has NLM journal title abbreviation: Contemp Clin Trials Commun
publication name: Contemporary clinical trials communications
language: eng
has national library of medicine journal id: 101671157
derived from: NLM
pg: 100749
has place of publication: Netherlands
source: Contemp Clin Trials Commun. 2021-06;22():100749.
volume: 22

Supersolids go two-dimensional.
pmid: 34408326
has PII: 10.1038/d41586-021-02191-5
doi: 10.1038/d41586-021-02191-5
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Laburthe-Tolra B
      type: Person
      first name: Bruno
      last name: Laburthe-Tolra
created: 2021-8-20T06:00
date last updated: 2025-01-20
issued: 2021-08
dp: 2021 08
created: 2021-8-19T06:35
e ISSN: 1476-4687
has issn l: 0028-0836
issue: 7872
has NLM journal title abbreviation: Nature
publication name: Nature
language: eng
has national library of medicine journal id: 0410462
derived from: NLM
starting page: 348
ending page: 349
has place of publication: England
has primary subject term: D011789
source: Nature. 2021-08;596(7872):348-349.
volume: 596

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.
pmid: 29440447
abstract: Activation of the unfolded protein response (UPR) signaling pathways is linked to multiple human diseases, including cancer. The inositol-requiring kinase 1α (IRE1α)-X-box binding protein 1 (XBP1) pathway is the most evolutionarily conserved of the three major signaling branches of the UPR. Here, we performed a genome-wide siRNA screen to obtain a systematic assessment of genes integrated in the IRE1α-XBP1 axis. We monitored the expression of an XBP1-luciferase chimeric protein in which luciferase was fused in-frame with the spliced (active) form of XBP1. Using cells expressing this reporter construct, we identified 162 genes for which siRNA inhibition resulted in alteration in XBP1 splicing. These genes express diverse types of proteins modulating a wide range of cellular processes. Pathway analysis identified a set of genes implicated in the pathogenesis of breast cancer. Several genes, including BCL10, GCLM, and IGF1R, correlated with worse relapse-free survival (RFS) in an analysis of patients with triple-negative breast cancer (TNBC). However, in this cohort of 1,908 patients, only high GCLM expression correlated with worse RFS in both TNBC and non-TNBC patients. Altogether, our study revealed unidentified roles of novel pathways regulating the UPR, and these findings may serve as a paradigm for exploring novel therapeutic opportunities based on modulating the UPR.Implications: Genome-wide RNAi screen identifies novel genes/pathways that modulate IRE1α-XBP1 signaling in human tumor cells and leads to the development of improved therapeutic approaches targeting the UPR.Visual Overview: http://mcr.aacrjournals.org/content/molcanres/16/5/745/F1.large.jpg Mol Cancer Res; 16(5); 745-53. ©2018 AACR.
rights: ©2018 American Association for Cancer Research.
has PII: 1541-7786.MCR-17-0307
doi: 10.1158/1541-7786.MCR-17-0307
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Yang Z
      type: Person
      first name: Zhifen
      last name: Yang
      member of: Department of Radiation Oncology, Stanford University, Stanford, California.
  slot:
    index: 2
    item: Zhang J
      type: Person
      first name: Jing
      last name: Zhang
      member of: Department of Radiation Oncology, Stanford University, Stanford, California.
  slot:
    index: 3
    item: Jiang D
      type: Person
      first name: Dadi
      last name: Jiang
      member of: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  slot:
    index: 4
    item: Khatri P
      type: Person
      first name: Purvesh
      last name: Khatri
      member of: Institute for Immunity, Transplantation and Infection, and Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, California.
  slot:
    index: 5
    item: Solow-Cordero DE
      type: Person
      first name: David E
      last name: Solow-Cordero
      member of: High-Throughput Bioscience Center, Department of Chemical and Systems Biology, Stanford University, Stanford, California.
  slot:
    index: 6
    item: Toesca DAS
      type: Person
      first name: Diego A S
      last name: Toesca
      member of: Department of Radiation Oncology, Stanford University, Stanford, California.
  slot:
    index: 7
    item: Koumenis C
      type: Person
      first name: Constantinos
      last name: Koumenis
      member of: Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
  slot:
    index: 8
    item: Denko NC
      type: Person
      first name: Nicholas C
      last name: Denko
      member of: Department of Radiation Oncology, The Ohio State University, Columbus, Ohio.
  slot:
    index: 9
    item: Giaccia AJ
      type: Person
      first name: Amato J
      last name: Giaccia
      member of: Department of Radiation Oncology, Stanford University, Stanford, California.
  slot:
    index: 10
    item: Le QT
      type: Person
      first name: Quynh-Thu
      last name: Le
      member of: Department of Radiation Oncology, Stanford University, Stanford, California.
  slot:
    index: 11
    item: Koong AC
      type: Person
      first name: Albert C
      last name: Koong
      member of: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. akoong@mdanderson.org.
created: 2018-2-15T06:00
date last updated: 2025-01-20
issued: 2018-05
dp: 2018 05
e ISSN: 1557-3125
has issn l: 1541-7786
issue: 5
has NLM journal title abbreviation: Mol Cancer Res
publication name: Molecular cancer research : MCR
language: eng
has national library of medicine journal id: 101150042
derived from: NLM
starting page: 745
ending page: 753
has place of publication: United States
has primary subject term: D015894Q000235
has primary subject term: D000071717Q000235
has subject term: D006801
has subject term: D034622
has subject term: D014162
source: Mol Cancer Res. 2018-05;16(5):745-753.
volume: 16

The online competition between pro- and anti-vaccination views.
pmid: 32499650
abstract: Distrust in scientific expertise1-14 is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks2-4, as happened for measles in 20195,6. Homemade remedies7,8 and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice9-11. There is a lack of understanding about how this distrust evolves at the system level13,14. Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change11, and highlight the key role of network cluster dynamics in multi-species ecologies15.
has PII: 10.1038/s41586-020-2281-1
doi: 10.1038/s41586-020-2281-1
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Johnson NF
      type: Person
      first name: Neil F
      last name: Johnson
      member of: Physics Department, George Washington University, Washington, DC, USA. neiljohnson@gwu.edu.Institute for Data, Democracy and Politics, George Washington University, Washington, DC, USA. neiljohnson@gwu.edu.
  slot:
    index: 2
    item: Velásquez N
      type: Person
      first name: Nicolas
      last name: Velásquez
      member of: Institute for Data, Democracy and Politics, George Washington University, Washington, DC, USA.
  slot:
    index: 3
    item: Restrepo NJ
      type: Person
      first name: Nicholas Johnson
      last name: Restrepo
      member of: Institute for Data, Democracy and Politics, George Washington University, Washington, DC, USA.
  slot:
    index: 4
    item: Leahy R
      type: Person
      first name: Rhys
      last name: Leahy
      member of: Institute for Data, Democracy and Politics, George Washington University, Washington, DC, USA.
  slot:
    index: 5
    item: Gabriel N
      type: Person
      first name: Nicholas
      last name: Gabriel
      member of: Physics Department, George Washington University, Washington, DC, USA.
  slot:
    index: 6
    item: El Oud S
      type: Person
      first name: Sara
      last name: El Oud
      member of: Physics Department, George Washington University, Washington, DC, USA.
  slot:
    index: 7
    item: Zheng M
      type: Person
      first name: Minzhang
      last name: Zheng
      member of: Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
  slot:
    index: 8
    item: Manrique P
      type: Person
      first name: Pedro
      last name: Manrique
      member of: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA.
  slot:
    index: 9
    item: Wuchty S
      type: Person
      first name: Stefan
      last name: Wuchty
      member of: Department of Computer Science, University of Miami, Coral Gables, FL, USA.
  slot:
    index: 10
    item: Lupu Y
      type: Person
      first name: Yonatan
      last name: Lupu
      member of: Department of Political Science, George Washington University, Washington, DC, USA.
created: 2020-6-6T06:00
date last updated: 2025-01-20
issued: 2020-06
dp: 2020 06
e ISSN: 1476-4687
has issn l: 0028-0836
issue: 7811
has NLM journal title abbreviation: Nature
publication name: Nature
language: eng
has national library of medicine journal id: 0410462
derived from: NLM
starting page: 230
ending page: 233
has place of publication: England
has primary subject term: D018352Q000453Q000517Q000523
has primary subject term: D038622
has primary subject term: D058873Q000517
has primary subject term: D011024Q000453Q000517
has primary subject term: D011639
has primary subject term: D061108Q000706
has primary subject term: D014611Q000523
has subject term: D000465
has subject term: http://id.nlm.nih.gov/mesh/D000086382
has subject term: http://id.nlm.nih.gov/mesh/D000086663
has subject term: D016000
has subject term: D006801
has subject term: D013997
has subject term: D014765
source: Nature. 2020-06;582(7811):230-233.
volume: 582

siRNA Therapeutics for Protein Misfolding Diseases of the Central Nervous System.
pmid: 33928585
abstract: Nanoparticles have been used to deliver siRNA to tissues and cells to silence specific genes in diverse organisms. Research and clinical application of nanoparticles like liposomes for drug delivery requires targeting them to specific anatomic regions or cell types, while avoiding off-target effects or clearance by the liver, kidney, or the immune system. Delivery to the central nervous system (CNS) presents additional challenges to cross the blood-brain barrier (BBB) to specific cell types like neurons, astrocytes, or glia. Here, we describe the generation of three different liposomal siRNA delivery vehicles to the CNS using the thin film hydration method. Utilizing cationic or anionic liposomes protects the siRNA from serum nucleases and proteases en route. To deliver the siRNA specifically to the CNS, the liposomes are complexed to a peptide that acts as a neuronal address by binding to nicotinic acetylcholine receptors (nAchRs). When injected intravenously or instilled intranasally, these liposome-siRNA-peptide complexes (LSPCs) or peptide addressed liposome-encapsulated therapeutic siRNA (PALETS) resist serum degradation, effectively cross the BBB, and deliver siRNA to AchR-expressing cells to suppress protein expression in the CNS.
doi: 10.1007/978-1-0716-1298-9_20
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Zabel MD
      type: Person
      first name: Mark D
      last name: Zabel
      member of: Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. mzabel@colostate.edu.
  slot:
    index: 2
    item: Mollnow L
      type: Person
      first name: Luke
      last name: Mollnow
      member of: Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  slot:
    index: 3
    item: Bender H
      type: Person
      first name: Heather
      last name: Bender
      member of: Prion Research Center, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
created: 2021-5-1T06:00
date last updated: 2025-01-20
issued: 2021
dp: 2021
created: 2021-4-30T07:09
e ISSN: 1940-6029
has issn l: 1064-3745
has NLM journal title abbreviation: Methods Mol Biol
publication name: Methods in molecular biology (Clifton, N.J.)
language: eng
has national library of medicine journal id: 9214969
derived from: NLM
starting page: 377
ending page: 394
has place of publication: United States
has primary subject term: D002493Q000235Q000378Q000628
has primary subject term: D018014
has primary subject term: D008055Q000737
has primary subject term: D011506Q000737
has primary subject term: D057165Q000235Q000378Q000628
has primary subject term: D034622
has primary subject term: D034741Q000737Q000235Q000378
has primary subject term: http://id.nlm.nih.gov/mesh/D000067492
has subject term: D000818
has subject term: D001812Q000378
has subject term: D008081
has subject term: D008815
has subject term: D017510
has subject term: D011978Q000235Q000378
has subject term: D051379
source: Methods Mol Biol. 2021;2282():377-394.
volume: 2282

Male engagement guidelines in antenatal care: unintended consequences for pregnant women in Tanzania.
pmid: 34702198
abstract: The meaningful engagement of male partners in antenatal care (ANC) can positively impact maternal and newborn health outcomes. The Tanzania National Plan for the Elimination of Mother to Child Transmission of HIV recommends male partners attend the first ANC appointment as a strategy for HIV prevention and treatment. This recommendation seeks to increase uptake of HIV and reproductive healthcare services, but unintended consequences of these guidelines may negatively impact women's ANC experiences. This study qualitatively examined the impact of policy promoting male engagement on women's ANC experiences.The study was conducted in two urban clinics in Kilimanjaro Region, Tanzania. In-depth interviews were conducted with 19 participants (13 women and 6 male partners) attending a first ANC appointment. A semi-structured guide was developed, applying Kabeer's Social Relations Approach. Data were analyzed using applied thematic analysis, combining memo writing, coding, synthesis, and comparison of themes.Male attendance impacted the timing of women's presentation to ANC and experience during the first ANC visit. Women whose partners could not attend delayed their presentation to first ANC due to fears of being interrogated or denied care because of their partner absence. Women presenting with partners were given preferential treatment by clinic staff, and women without partners felt discriminated against. Women perceived that the clinic prioritized men's HIV testing over involvement in pregnancy care.Study findings indicate the need to better assess and understand the unintended impact of policies promoting male partner attendance at ANC. Although male engagement can benefit the health outcomes of mothers and newborn children, our findings demonstrate the need for improved methods of engaging men in ANC. ANC clinics should identify ways to make clinic settings more male friendly, utilize male attendance as an opportunity to educate and engage men in pregnancy and newbor[cell cut: 2125 characters, first 2000 kept]
rights: © 2021. The Author(s).
has PII: 10.1186/s12884-021-04141-5
doi: 10.1186/s12884-021-04141-5
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Osaki H
      type: Person
      first name: Haika
      last name: Osaki
      member of: Kilimanjaro Clinical Research Institute, Moshi, Tanzania. h.osaki@kcri.ac.tz.
  slot:
    index: 2
    item: Sao SS
      type: Person
      first name: Saumya S
      last name: Sao
      member of: Duke Global Health Institute, Duke University, Durham, NC, USA.
  slot:
    index: 3
    item: Kisigo GA
      type: Person
      first name: Godfrey A
      last name: Kisigo
      member of: Kilimanjaro Clinical Research Institute, Moshi, Tanzania.Duke Global Health Institute, Duke University, Durham, NC, USA.
  slot:
    index: 4
    item: Coleman JN
      type: Person
      first name: Jessica N
      last name: Coleman
      member of: Duke Global Health Institute, Duke University, Durham, NC, USA.Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.
  slot:
    index: 5
    item: Mwamba RN
      type: Person
      first name: Rimel N
      last name: Mwamba
      member of: Duke Global Health Institute, Duke University, Durham, NC, USA.
  slot:
    index: 6
    item: Renju J
      type: Person
      first name: Jenny
      last name: Renju
      member of: Department of Epidemiology and Biostatistics, Kilimanjaro Christian Medical University College, Moshi, Tanzania.Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.
  slot:
    index: 7
    item: Mmbaga BT
      type: Person
      first name: Blandina T
      last name: Mmbaga
      member of: Kilimanjaro Clinical Research Institute, Moshi, Tanzania.Department of Epidemiology and Biostatistics, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
  slot:
    index: 8
    item: Watt MH
      type: Person
      first name: Melissa H
      last name: Watt
      member of: Duke Global Health Institute, Duke University, Durham, NC, USA.Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
created: 2021-10-28T06:00
date last updated: 2025-01-20
issued: 2021-10-26
dp: 2021 Oct 26
created: 2021-10-27T05:36
e ISSN: 1471-2393
has issn l: 1471-2393
issue: 1
has NLM journal title abbreviation: BMC Pregnancy Childbirth
publication name: BMC pregnancy and childbirth
language: eng
has national library of medicine journal id: 100967799
derived from: NLM
pg: 720
has place of publication: England
has primary subject term: D000553Q000592
has primary subject term: D010358Q000523
has primary subject term: D037841Q000523
has primary subject term: D011295Q000592
has primary subject term: D018454
has subject term: D000328
has subject term: D005260
has subject term: D017408Q000592
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D057766
has subject term: D011247
has subject term: D036301
has subject term: D013636
has subject term: D019037
source: BMC Pregnancy Childbirth. 2021-10-26;21(1):720.
volume: 21

It is not always positive: emotional bias in young and older adults.
pmid: 34704157
abstract: Healthy ageing has been associated with a bias toward positive information and greater psychological well-being. However, to what extent this positivity bias also applies to prioritizing positive information under emotional competition is unclear. Old and young adults performed a word-face interference task, in which they responded to the valence of positive and negative target-words while ignoring happy or angry distractor-faces that could be affectively congruent or incongruent. A control condition with scrambled neutral distractor-faces was also used. Findings showed small facilitation effects with faster responses when targets and distractors were affectively congruent and large interference effects with slower responses when targets and distractors were affectively incongruent compared to the control condition. Importantly, whereas for younger adults there was a similar pattern of interference from happy and angry distractor-faces, for older adults there was greater interference from angry distractor-faces. The present findings are discussed in the context of emotional bias literature.
rights: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00426-021-01614-2
doi: 10.1007/s00426-021-01614-2
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Viviani G
      type: Person
      first name: Giada
      last name: Viviani
      member of: Department of Psychology, Sapienza University of Rome, Rome, Italy.
  slot:
    index: 2
    item: De Luca F
      type: Person
      first name: Francesca
      last name: De Luca
      member of: Department of Psychology, Sapienza University of Rome, Rome, Italy.
  slot:
    index: 3
    item: Antonucci G
      type: Person
      first name: Gabriella
      last name: Antonucci
  slot:
    index: 4
    item: Yankouskaya A
      type: Person
      first name: Alla
      last name: Yankouskaya
      member of: Department of Psychology, Bournemouth University, Poole, UK.
  slot:
    index: 5
    item: Pecchinenda A
      type: Person
      first name: Anna
      last name: Pecchinenda
      member of: Department of Psychology, Sapienza University of Rome, Rome, Italy. anna.pecchinenda@uniroma1.it.
created: 2021-10-28T06:00
date last updated: 2025-01-20
issued: 2022-09
dp: 2022 Sep
created: 2021-10-27T07:17
e ISSN: 1430-2772
has issn l: 0340-0727
issue: 6
has NLM journal title abbreviation: Psychol Res
publication name: Psychological research
language: eng
has national library of medicine journal id: 0435062
derived from: NLM
starting page: 2045
ending page: 2057
has place of publication: Germany
has primary subject term: D004644
has primary subject term: D005149
has subject term: D000368
has subject term: D000786
has subject term: D015982
has subject term: D006240
has subject term: http://id.nlm.nih.gov/mesh/D000073656
has subject term: D006801
has subject term: D055815
source: Psychol Res. 2022-09;86(6):2045-2057.
volume: 86

Validation of Diagnosis Codes to Identify Infection-Related Acute Care Events in Patients With Glomerular Disease.
pmid: 34901577
has PII: S2468-0249(21)01404-2
doi: 10.1016/j.ekir.2021.08.019
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Glenn DA
      type: Person
      first name: Dorey A
      last name: Glenn
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 2
    item: Zee J
      type: Person
      first name: Jarcy
      last name: Zee
      member of: Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  slot:
    index: 3
    item: Hegde A
      type: Person
      first name: Anisha
      last name: Hegde
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 4
    item: Henderson C
      type: Person
      first name: Candace
      last name: Henderson
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 5
    item: O'Shaughnessy MM
      type: Person
      first name: Michelle M
      last name: O'Shaughnessy
      member of: Department of Renal Medicine, University College Cork, Cork, Ireland.
  slot:
    index: 6
    item: Bomback A
      type: Person
      first name: Andrew
      last name: Bomback
      member of: Division of Nephrology, Columbia University, New York, New York, USA.
  slot:
    index: 7
    item: Gibson K
      type: Person
      first name: Keisha
      last name: Gibson
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 8
    item: Greenbaum LA
      type: Person
      first name: Larry A
      last name: Greenbaum
      member of: Division of Pediatric Nephrology, Department of Pediatrics, Emory University, Atlanta, Georgia, USA.
  slot:
    index: 9
    item: Mansfield S
      type: Person
      first name: Sarah
      last name: Mansfield
      member of: Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA.
  slot:
    index: 10
    item: Hu Y
      type: Person
      first name: Yichun
      last name: Hu
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 11
    item: Mariani L
      type: Person
      first name: Laura
      last name: Mariani
      member of: Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  slot:
    index: 12
    item: Falk R
      type: Person
      first name: Ronald
      last name: Falk
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 13
    item: Hogan S
      type: Person
      first name: Susan
      last name: Hogan
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  slot:
    index: 14
    item: Denburg M
      type: Person
      first name: Michelle
      last name: Denburg
      member of: Division of Nephrology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  slot:
    index: 15
    item: Mottl A
      type: Person
      first name: Amy
      last name: Mottl
      member of: Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
creator: CureGN Consortium
created: 2021-12-14T06:00
date last updated: 2025-01-20
issued: 2021-12
dp: 2021 Dec
created: 2021-12-13T18:14
e ISSN: 2468-0249
has issn l: 2468-0249
issue: 12
has NLM journal title abbreviation: Kidney Int Rep
publication name: Kidney international reports
language: eng
has national library of medicine journal id: 101684752
derived from: NLM
starting page: 3079
ending page: 3082
has place of publication: United States
source: Kidney Int Rep. 2021-12;6(12):3079-3082.
volume: 6

Abnormal lymphatic phenotype in a CRISPR mouse model of the human lymphedema-causing Connexin47 R260C point mutation.
pmid: 34735753
abstract: Connexin proteins form gap junctions controlling exchange of ions and small molecules between cells and play an important role in movement of lymph within lymphatic vessels. Connexin47 (CX47) is highly expressed in lymphatic endothelial cells and CX47 missense mutations, i.e., R260C, cosegregate with primary lymphedema in humans. However, studies utilizing CX47 knockout mice have failed to demonstrate any lymphatic anomalies. To unravel the lymphatic consequences of expressing a mutant CX47 protein, we used CRISPR technology to create a mouse carrying a Cx47 missense mutation (Cx47R259C) equivalent to the human CX47R260C missense mutation associated with human primary lymphedema. Intradermal Evans Blue dye injection identified a 2-fold increase in regional lymph nodes in homozygous Cx47R259C mice compared to wildtype, particularly in the jugular region (4.8 ± 0.4 and 2.0 ± 0.0, respectively, p<0.01). Associated lymphatic channels were increased in Cx47R259C mice and mesenteric lymph reflux occurred in homozygous Cx47R259C mice but not in wildtype. Contractility of superficial cervical lymphatics, assessed by pressure myography, was reduced in homozygous Cx47R259C mice compared to wildtype. In conclusion, our data are the first to demonstrate a role for the Cx47 protein in lymphatic anatomy and function. This phenotype is similar to that found with other valve deficient mouse mutants, e.g., in Foxc2. Of significance, this study is the first to use CRISPR technology to develop a pre-clinical model of primary lymphedema and demonstrates the importance of distinguishing between lack of and presence of mutant protein when developing clinically relevant animal models for translation of pre-clinical findings.
rights: Copyright by International Society of Lymphology.
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Mustacich DJ
      type: Person
      first name: D J
      last name: Mustacich
      member of: Department of Surgery, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 2
    item: Kylat RI
      type: Person
      first name: R I
      last name: Kylat
      member of: Department of Pediatrics, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 3
    item: Bernas MJ
      type: Person
      first name: M J
      last name: Bernas
      member of: Department of Surgery, University of Arizona, Tucson, Arizona, USA.Department of Medical Education, TCU and UNTHSC School of Medicine, Fort Worth, TX, USA.
  slot:
    index: 4
    item: Myles RJ
      type: Person
      first name: R J
      last name: Myles
      member of: Department of Surgery, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 5
    item: Jones JA
      type: Person
      first name: J A
      last name: Jones
      member of: Department of Surgery, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 6
    item: Kanady JD
      type: Person
      first name: J D
      last name: Kanady
      member of: Department of Physiology, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 7
    item: Simon AM
      type: Person
      first name: A M
      last name: Simon
      member of: Department of Physiology, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 8
    item: Georgieva TG
      type: Person
      first name: T G
      last name: Georgieva
      member of: GEMM Core, Bio5 Institute, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 9
    item: Witte MH
      type: Person
      first name: M H
      last name: Witte
      member of: Department of Surgery, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 10
    item: Erickson RP
      type: Person
      first name: R P
      last name: Erickson
      member of: Department of Pediatrics, University of Arizona, Tucson, Arizona, USA.
  slot:
    index: 11
    item: Pires PW
      type: Person
      first name: P W
      last name: Pires
      member of: Department of Physiology, University of Arizona, Tucson, Arizona, USA.
created: 2021-11-5T06:00
date last updated: 2025-01-20
issued: 2021
dp: 2021
created: 2021-11-4T17:38
e ISSN: 2522-7963
has issn l: 0024-7766
issue: 2
has NLM journal title abbreviation: Lymphology
publication name: Lymphology
language: eng
has national library of medicine journal id: 0155112
derived from: NLM
starting page: 78
ending page: 91
has place of publication: United States
has primary subject term: D042601Q000473
has primary subject term: D008209Q000473
has subject term: D000818
has subject term: D064112
has subject term: D017630Q000235
has subject term: D042783Q000378Q000473
has subject term: D006801
has subject term: D051379
has subject term: D018345
has subject term: D010641
has subject term: D017354
source: Lymphology. 2021;54(2):78-91.
volume: 54

Exploring the genetic potential of Pakistani soybean cultivars through RNA-seq based transcriptome analysis.
pmid: 35088376
abstract: Soybean is largely grown and considered among the top oilseed crops. Three Pakistani cultivars, NARC-II (N), Swat-84 (S), and Rawal-I (R) were employed for RNA-Seq based transcriptome analysis to explore their genetic potential and performance in our local environment.We grew the plants in glass house at same conditions and sampled leaves for RNA-Seq analysis in triplicate for each variety. We retrieved 2225 differentially expressed genes (DEGs) between S vs R, 2591 DEGs between S vs N, and 1221 DEGs between R vs N cultvars. These genes consist of transcription factors representing Basic Helix-loop Helix, myeloblastosis, ethylene response factors, and WRKY amino acid motif (WRKY) type major families that were up-regulated. KEGG pathway analysis revealed that MAPK, plant hormone signal transduction, and Phenylpropanoid biosynthesis pathways were the most dominant pathways involved in plant defense and growth. Comparative analysis showed that Swat-84 (S) cultivar had better gene expression among these varieties having higher number of DEGs, where mostly genes related to important phenotypic traits were up regulated.This is a pilot study to investigate and functionally characterise the DEG involved in the stress response in the cultivars studied.
rights: © 2021. The Author(s), under exclusive licence to Springer Nature B.V.
has PII: 10.1007/s11033-021-07104-3
doi: 10.1007/s11033-021-07104-3
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Tariq A
      type: Person
      first name: Arslan
      last name: Tariq
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
  slot:
    index: 2
    item: Jabeen Z
      type: Person
      first name: Zahra
      last name: Jabeen
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
  slot:
    index: 3
    item: Farrakh S
      type: Person
      first name: Sumaira
      last name: Farrakh
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
  slot:
    index: 4
    item: Noreen K
      type: Person
      first name: Kiran
      last name: Noreen
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
  slot:
    index: 5
    item: Arshad W
      type: Person
      first name: Waleed
      last name: Arshad
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
  slot:
    index: 6
    item: Ahmed H
      type: Person
      first name: Haroon
      last name: Ahmed
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
  slot:
    index: 7
    item: Haider W
      type: Person
      first name: Waseem
      last name: Haider
      member of: Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. waseem_haider@comsats.edu.pk.
created: 2022-1-29T06:00
date last updated: 2025-01-20
issued: 2022-04
dp: 2022 Apr
created: 2022-1-28T05:57
e ISSN: 1573-4978
has issn l: 0301-4851
issue: 4
has NLM journal title abbreviation: Mol Biol Rep
publication name: Molecular biology reports
language: eng
has national library of medicine journal id: 0403234
derived from: NLM
starting page: 2889
ending page: 2897
has place of publication: Netherlands
has primary subject term: D018506Q000235
has primary subject term: D013025Q000235Q000378
has subject term: D020869Q000379
has subject term: D006801
has subject term: D010154
has subject term: D010865
has subject term: http://id.nlm.nih.gov/mesh/D000081246
has subject term: D059467Q000235
source: Mol Biol Rep. 2022-04;49(4):2889-2897.
volume: 49

Broadband internet subscription rates and opioid prescribing via telemedicine during the COVID-19 pandemic.
pmid: 35224768
abstract: In response to the COVID-19 pandemic, the US DEA allowed controlled substance prescriptions to be issued following a telemedicine encounter. This study evaluated changes in opioid prescribing in Kentucky counties with low and high rates of broadband subscription before, during, and after a series of statewide emergency declarations that may have affected health care access.The study used the prescription drug monitoring program to analyze records of opioid analgesic prescriptions dispensed to opioid-naïve individuals in high (N = 26) and low (N = 94) broadband access counties during 3 periods: before a state of emergency (SOE) and executive order (EO) limiting nonemergent health care services (January 2019-February 2020), while the EO was active (March-April 2020), and after health care services began reopening (May-December 2020). Marginal generalized estimating equations-type negative binomial models were fit to compare prescription counts by broadband access over the 3 periods.Rates of opioid dispensing to opioid-naïve individuals decreased significantly during the EO, but increased nearly to pre-SOE levels after health care services began reopening. Dispensing rates in low broadband counties were higher than those in high broadband counties during all time periods, although these differences were negligible after adjusting for potential confounders. During the EO, prescriptions were written for longer days' supply in both county types.The overall dramatic reduction in opioid prescribing rates should be considered when evaluating annual opioid prescribing trends. However, broadband subscription rate did not appear to influence opioid prescriptions dispensed in Kentucky during the EO.
rights: © 2022 National Rural Health Association.
doi: 10.1111/jrh.12653
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Oyler DR
      type: Person
      first name: Douglas R
      last name: Oyler
      member of: Department of Pharmacy Practice and Science, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 2
    item: Slavova S
      type: Person
      first name: Svetla
      last name: Slavova
      member of: Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.Kentucky Injury Prevention and Research Center, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 3
    item: Freeman PR
      type: Person
      first name: Patricia R
      last name: Freeman
      member of: Department of Pharmacy Practice and Science, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 4
    item: Huang Z
      type: Person
      first name: Zhengyan
      last name: Huang
      member of: Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 5
    item: Talbert J
      type: Person
      first name: Jeffery
      last name: Talbert
      member of: Department of Biomedical Informatics, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 6
    item: Walsh SL
      type: Person
      first name: Sharon L
      last name: Walsh
      member of: Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, USA.Center on Drug and Alcohol Research, University of Kentucky, Lexington, Kentucky, USA.
  slot:
    index: 7
    item: Westgate PM
      type: Person
      first name: Philip M
      last name: Westgate
      member of: Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
created: 2022-3-1T06:00
date last updated: 2025-01-20
issued: 2022-09
dp: 2022 09
created: 2022-2-28T05:44
e ISSN: 1748-0361
has issn l: 0890-765X
issue: 4
has NLM journal title abbreviation: J Rural Health
publication name: The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association
language: eng
has national library of medicine journal id: 8508122
derived from: NLM
starting page: 900
ending page: 907
has place of publication: England
has primary subject term: D000086382Q000453
has primary subject term: D017216
has primary subject term: http://id.nlm.nih.gov/mesh/D000093485
has subject term: D000701Q000627
has subject term: D061891
has subject term: D006801
has subject term: D020407
has subject term: D058873
has subject term: D010818
source: J Rural Health. 2022-09;38(4):900-907.
volume: 38

A gene-to-patient approach uplifts novel disease gene discovery and identifies 18 putative novel disease genes.
pmid: 35532742
abstract: Exome and genome sequencing have drastically accelerated novel disease gene discoveries. However, discovery is still hindered by myriad variants of uncertain significance found in genes of undetermined biological function. This necessitates intensive functional experiments on genes of equal predicted causality, leading to a major bottleneck.We apply the loss-of-function observed/expected upper-bound fraction metric of intolerance to gene inactivation to curate a list of predicted haploinsufficient disease genes. Using data from the 100,000 Genomes Project, we adopt a gene-to-patient approach that matches de novo loss-of-function variants in constrained genes to patients with rare disease. Through large-scale aggregation of data, we reduce excess analytical noise currently hindering novel discoveries.Results from 13,949 trios revealed 643 rare, de novo predicted loss-of-function events filtered from 1044 loss-of-function observed/expected upper-bound fraction-constrained genes. A total of 168 variants occurred within 126 genes without a known disease-gene relationship. Of these, 27 genes had >1 kindred affected, and for 18 of these genes, multiple kindreds had overlapping phenotypes. Two years after initial analysis, 11 of 18 (61%) of these genes have been independently published as novel disease gene discoveries.Using large cohorts and adopting gene-based approaches can rapidly and objectively accelerate dominantly inherited novel gene discovery by targeting the most appropriate genes for functional validation.
rights: Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S1098-3600(22)00748-1
doi: 10.1016/j.gim.2022.04.019
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Seaby EG
      type: Person
      first name: Eleanor G
      last name: Seaby
      member of: Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Program in Medical and Population Genetics, Broad institute of MIT and Harvard, Boston, MA; Center for Genomic Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA. Electronic address: E.Seaby@soton.ac.uk.
  slot:
    index: 2
    item: Smedley D
      type: Person
      first name: Damian
      last name: Smedley
      member of: Genomics England, Dawson Hall, Charterhouse Square, London, EC1M 6BQ, United Kingdom.
  slot:
    index: 3
    item: Taylor Tavares AL
      type: Person
      first name: Ana Lisa
      last name: Taylor Tavares
      member of: Genomics England, Dawson Hall, Charterhouse Square, London, EC1M 6BQ, United Kingdom.
  slot:
    index: 4
    item: Brittain H
      type: Person
      first name: Helen
      last name: Brittain
      member of: Genomics England, Dawson Hall, Charterhouse Square, London, EC1M 6BQ, United Kingdom.
  slot:
    index: 5
    item: van Jaarsveld RH
      type: Person
      first name: Richard H
      last name: van Jaarsveld
      member of: Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
  slot:
    index: 6
    item: Baralle D
      type: Person
      first name: Diana
      last name: Baralle
      member of: Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  slot:
    index: 7
    item: Rehm HL
      type: Person
      first name: Heidi L
      last name: Rehm
      member of: Program in Medical and Population Genetics, Broad institute of MIT and Harvard, Boston, MA; Center for Genomic Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.
  slot:
    index: 8
    item: O'Donnell-Luria A
      type: Person
      first name: Anne
      last name: O'Donnell-Luria
      member of: Program in Medical and Population Genetics, Broad institute of MIT and Harvard, Boston, MA; Center for Genomic Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA.
  slot:
    index: 9
    item: Ennis S
      type: Person
      first name: Sarah
      last name: Ennis
      member of: Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
creator: Genomics England Research Consortium
created: 2022-5-10T06:00
date last updated: 2025-01-20
issued: 2022-08
dp: 2022 08
created: 2022-5-9T11:03
e ISSN: 1530-0366
has issn l: 1098-3600
issue: 8
has NLM journal title abbreviation: Genet Med
publication name: Genetics in medicine : official journal of the American College of Medical Genetics
language: eng
has national library of medicine journal id: 9815831
derived from: NLM
starting page: 1697
ending page: 1707
has place of publication: United States
has primary subject term: D059472Q000235
has subject term: D056726
has subject term: D006801
has subject term: D010641
has subject term: http://id.nlm.nih.gov/mesh/D000073359
source: Genet Med. 2022-08;24(8):1697-1707.
volume: 24

Ski Regulates the Inflammatory Response of Reactive Astrocytes Induced by Oxygen Glucose Deprivation/Reoxygenation (OGD/R) Through the NF-κB Pathway.
pmid: 35339646
abstract: Spinal cord injury (SCI) is a common disease of the nervous system, including primary and secondary injuries. Neuronal inflammation after SCI is the most important pathological process of SCI and a chemical barrier to nerve function recovery after injury. Ski, an evolutionarily conserved functional transcriptional regulator protein, is upregulated in reactive astrocytes after SCI and regulates the biological characteristics of astrocytes. However, its role in the glial inflammatory response triggered by reactive astrocytes after spinal cord ischemia and its exact mechanism remains unclear. This study investigated the role and mechanism of Ski in the inflammatory response triggered by reactive astrocytes induced by oxygen and sugar deprivation/reoxygenation (OGD/R) model in vitro. In the ODG/R model, Ski expression was upregulated. In contrast, Ski upregulation was accompanied by increased levels of iNOS, IL-1β, IL-6, TNF-α, and other inflammation-related factors. These results indicated that the inflammatory response triggered by astrocytes was significantly enhanced in OGD/R-stimulated astrocytes. Astrocytes were transfected with Ski specific siRNA to knock out Ski and subsequently attenuate OGD-induced astrocyte-triggered inflammation. Our results also suggest that Ski downregulation downregulates the expression of iNOS, IL-1β, IL-6, and TNF-α in OGD/R-induced reactive astrocytes by inhibiting the activity of the NF-κB signaling pathway. In conclusion, downregulation of Ski can effectively inhibit glial inflammation in SCI by inhibiting the activity of the NF-κB pathway. These findings suggest that Ski is a promising therapeutic target for inflammatory responses after SCI.In conclusion, Ski downregulation can effectively inhibit glial inflammation in SCI by inhibiting the activity of the NF-κB pathway. These findings suggest that Ski might serve as a promising target for the treatment of inflammatory responses after SCI.
rights: Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
has PII: S0306-4522(22)00076-8
doi: 10.1016/j.neuroscience.2022.02.015
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Liao HY
      type: Person
      first name: Hai-Yang
      last name: Liao
      member of: The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China.
  slot:
    index: 2
    item: Ran R
      type: Person
      first name: Rui
      last name: Ran
      member of: The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China.
  slot:
    index: 3
    item: Da CM
      type: Person
      first name: Chao-Ming
      last name: Da
      member of: The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China; Gansu Provincial Maternal and Child Health Hospital, 143 Qilihe North Street, Lanzhou 730050, PR China.
  slot:
    index: 4
    item: Wang ZQ
      type: Person
      first name: Zhi-Qiang
      last name: Wang
      member of: The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China.
  slot:
    index: 5
    item: Zhou KS
      type: Person
      first name: Kai-Sheng
      last name: Zhou
      member of: The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China.
  slot:
    index: 6
    item: Zhang HH
      type: Person
      first name: Hai-Hong
      last name: Zhang
      member of: The Second Clinical Medical College of Lanzhou University, Lanzhou 730000, PR China; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730000, PR China. Electronic address: 840620161@qq.com.
created: 2022-3-28T06:00
date last updated: 2025-01-19
issued: 2022-05-10
dp: 2022 05 10
created: 2022-3-27T20:21
e ISSN: 1873-7544
has issn l: 0306-4522
has NLM journal title abbreviation: Neuroscience
publication name: Neuroscience
language: eng
has national library of medicine journal id: 7605074
derived from: NLM
starting page: 250
ending page: 263
has place of publication: United States
has primary subject term: D016328Q000378
has primary subject term: D011518Q000378
has primary subject term: D013119Q000378
has subject term: D000818
has subject term: D001253Q000378
has subject term: D005947Q000378
has subject term: D007249Q000378
has subject term: D015850Q000378
has subject term: D010100Q000378
has subject term: D051381
has subject term: D017207
has subject term: D014409Q000378
source: Neuroscience. 2022-05-10;490():250-263.
volume: 490

Between-Subject and Within-Subject Variaton of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest.
pmid: 35273514
abstract: To improve quantification of individual responses to bed rest interventions, we analyzed peripheral quantitative computer tomography (pQCT) datasets of the lower leg of 76 participants, who took part in eight different bed rest studies. A newly developed statistical approach differentiated measurement uncertainty U Meas from between-subject-variation (BSV) and within-subject variation (WSV). The results showed that U Meas decreased 59.3-80% over the two decades of bed rest studies (p < 0.01), and that it was higher for muscles than for bones. The reduction of U Meas could be explained by improved measurement procedures as well as a higher standardization. The vast majority (89.6%) of the individual responses pc i exceeded the 95% confidence interval defined by U Meas , indicating significant and substantial BSV, which was greater for bones than for muscles, especially at the epiphyseal measurement sites. Non-significant to small positive inter-site correlations between bone sites, but very large positive inter-site correlation between muscle sites suggests that substantial WSV exists in the tibia bone, but much less so in the calf musculature. Furthermore, endocortical circumference, an indicator of the individual's bone geometry could partly explain WSV and BSV. These results demonstrate the existence of substantial BSV bone, and that it is partly driven by WSV, and likely also by physical activity and dietary habits prior to bed rest. In addition, genetic and epigenetic variation could potentially explain BSV, but not WSV. As to the latter, differences of bone characteristics and the bone resorption process could offer an explanation for its existence. The study has also demonstrated the importance of duplicate baseline measurements. Finally, we provide here a rationale for worst case scenarios with partly effective countermeasures in long-term space missions.
rights: Copyright © 2022 Böcker, Schmitz, Mittag, Jordan and Rittweger.
doi: 10.3389/fphys.2021.743876
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Böcker J
      type: Person
      first name: Jonas
      last name: Böcker
      member of: Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.
  slot:
    index: 2
    item: Schmitz MT
      type: Person
      first name: Marie-Therese
      last name: Schmitz
      member of: Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.Institute of Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany.
  slot:
    index: 3
    item: Mittag U
      type: Person
      first name: Uwe
      last name: Mittag
      member of: Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.
  slot:
    index: 4
    item: Jordan J
      type: Person
      first name: Jens
      last name: Jordan
      member of: Chair of Aerospace Medicine, University of Cologne, Cologne, Germany.German Aerospace Center, Head of Institute of Aerospace Medicine, Cologne, Germany.
  slot:
    index: 5
    item: Rittweger J
      type: Person
      first name: Jörn
      last name: Rittweger
      member of: Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.Department of Pediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.
created: 2022-3-12T06:00
date last updated: 2025-01-20
issued: 2021
dp: 2021
created: 2022-3-11T05:39
ISSN: 1664-042X
has issn l: 1664-042X
has NLM journal title abbreviation: Front Physiol
publication name: Frontiers in physiology
language: eng
has national library of medicine journal id: 101549006
derived from: NLM
pg: 743876
has place of publication: Switzerland
source: Front Physiol. 2021;12():743876.
volume: 12

Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis.
pmid: 34997540
abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier studies have shown that motor neuron degeneration begins in motor cortex and descends to the neuromuscular junction (NMJ) in a dying forward fashion. However, accumulating evidences support that ALS is a distal axonopathy where early pathological changes occur at the NMJ, prior to onset of clinical symptoms and propagates towards the motor neuron cell body supporting dying back hypothesis. Despite several evidences, series of events triggering NMJ disassembly in ALS are still obscure. Neuromuscular junction is a specialized tripartite chemical synapse which involves a well-coordinated communication among the presynaptic motor neuron, postsynaptic skeletal muscle, and terminal Schwann cells. This review provides comprehensive insight into the role of NMJ in ALS pathogenesis. We have emphasized the molecular alterations in cellular components of NMJ leading to loss of effective neuromuscular transmission in ALS. Further, we provide a preview into research involved in exploring NMJ as potential target for designing effective therapies for ALS.
rights: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12035-021-02658-6
doi: 10.1007/s12035-021-02658-6
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Verma S
      type: Person
      first name: Sagar
      last name: Verma
      member of: Department of Research, Sir Ganga Ram Hospital, Delhi, India.Department of Biotechnology, Jamia Hamdard, Delhi, India.
  slot:
    index: 2
    item: Khurana S
      type: Person
      first name: Shiffali
      last name: Khurana
      member of: Department of Research, Sir Ganga Ram Hospital, Delhi, India.Department of Biomedical Science, Bhaskaracharya College of Applied Sciences, University of Delhi, Delhi, India.
  slot:
    index: 3
    item: Vats A
      type: Person
      first name: Abhishek
      last name: Vats
      member of: Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  slot:
    index: 4
    item: Sahu B
      type: Person
      first name: Bandana
      last name: Sahu
      member of: Department of Research, Sir Ganga Ram Hospital, Delhi, India.
  slot:
    index: 5
    item: Ganguly NK
      type: Person
      first name: Nirmal Kumar
      last name: Ganguly
      member of: Department of Research, Sir Ganga Ram Hospital, Delhi, India.
  slot:
    index: 6
    item: Chakraborti P
      type: Person
      first name: Pradip
      last name: Chakraborti
      member of: Department of Biotechnology, Jamia Hamdard, Delhi, India.
  slot:
    index: 7
    item: Gourie-Devi M
      type: Person
      first name: Mandaville
      last name: Gourie-Devi
      member of: Department of Neurophysiology, Sir Ganga Ram Hospital, Delhi, India.
  slot:
    index: 8
    item: Taneja V
      type: Person
      first name: Vibha
      last name: Taneja
      member of: Department of Research, Sir Ganga Ram Hospital, Delhi, India. vibha.taneja@sgrh.com.
created: 2022-1-9T06:00
date last updated: 2025-01-20
issued: 2022-03
dp: 2022 Mar
created: 2022-1-8T06:13
e ISSN: 1559-1182
has issn l: 0893-7648
issue: 3
has NLM journal title abbreviation: Mol Neurobiol
publication name: Molecular neurobiology
language: eng
has national library of medicine journal id: 8900963
derived from: NLM
starting page: 1502
ending page: 1527
has place of publication: United States
has primary subject term: D000690Q000473
has subject term: D006801
has subject term: D009046Q000473
has subject term: D018482Q000473
has subject term: D009469
has subject term: http://id.nlm.nih.gov/mesh/D000072105
has subject term: D013569Q000473
source: Mol Neurobiol. 2022-03;59(3):1502-1527.
volume: 59

Impact of malnutrition on clinical outcomes in patients diagnosed with COVID-19.
pmid: 35672915
abstract: Coronavirus disease 2019 (COVID-19) is now the third leading cause of death in the United States. Malnutrition in hospitalized patients increases risk of complications. However, the effect of malnutrition on outcomes in patients infected is unclear. This study aims to identify the impact of malnutrition on mortality and adverse hospital events in patients hospitalized with COVID-19.This study used data from the National COVID Cohort Collaborative (N3C), a COVID-19 repository containing harmonized, longitudinal electronic health record data from US health systems. Malnutrition was categorized into three groups based on condition diagnosis: (1) none documented, (2) history of malnutrition, and (3) hospital-acquired malnutrition. Multivariable logistic regression was performed to determine whether malnutrition was associated with mortality and adverse events, including mechanical ventilation, acute respiratory distress syndrome, extracorporeal membrane oxygenation, and hospital-acquired pressure injury, in hospitalized patients with COVID-19.Of 343,188 patients hospitalized with COVID-19, 11,206 had a history of malnutrition and 15,711 had hospital-acquired malnutrition. After adjustment for potential confounders, odds of mortality were significantly higher in patients with a history of malnutrition (odds ratio [OR], 1.71; 95% confidence interval [CI], 1.63-1.79; P < 0.001) and hospital-acquired malnutrition (OR, 2.5; 95% CI, 2.4-2.6; P < 0.001). Adjusted odds of adverse hospital events were also significantly elevated in both malnutrition groups.Results indicate the risk of mortality and adverse inpatient events in adults with COVID-19 is significantly higher in patients with malnutrition. Prevention, diagnosis, and treatment of malnutrition could be a key component in improving outcomes in these patients.
rights: © 2022 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition.
doi: 10.1002/jpen.2418
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Ponce J
      type: Person
      first name: Jana
      last name: Ponce
      member of: University of Nebraska Medical Center, College of Allied Health Professions, Omaha, Nebraska, USA.Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, Nebraska, USA.
  slot:
    index: 2
    item: Anzalone AJ
      type: Person
      first name: Alfred Jerrod
      last name: Anzalone
      member of: Department of Neurological Sciences, University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska, USA.Great Plains IDeA-CTR, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  slot:
    index: 3
    item: Bailey K
      type: Person
      first name: Kristina
      last name: Bailey
      member of: Department of Internal Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska, USA.Veterans Administration Nebraska-Iowa Health Systems, Omaha, Nebraska, USA.
  slot:
    index: 4
    item: Sayles H
      type: Person
      first name: Harlan
      last name: Sayles
      member of: Department of Biostatistics, University of Nebraska Medical Center, College of Public Health, Omaha, Nebraska, USA.
  slot:
    index: 5
    item: Timmerman M
      type: Person
      first name: Megan
      last name: Timmerman
      member of: University of Nebraska Medical Center, College of Allied Health Professions, Omaha, Nebraska, USA.Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, Nebraska, USA.
  slot:
    index: 6
    item: Jackson M
      type: Person
      first name: Mariah
      last name: Jackson
      member of: University of Nebraska Medical Center, College of Allied Health Professions, Omaha, Nebraska, USA.
  slot:
    index: 7
    item: McClay J
      type: Person
      first name: James
      last name: McClay
      member of: Department of Emergency Medicine, University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska, USA.
  slot:
    index: 8
    item: Hanson C
      type: Person
      first name: Corrine
      last name: Hanson
      member of: University of Nebraska Medical Center, College of Allied Health Professions, Omaha, Nebraska, USA.
creator: National COVID Cohort Collaborative (N3C) Consortium
created: 2022-6-9T06:00
date last updated: 2025-01-20
issued: 2022-11
dp: 2022 11
created: 2022-6-8T00:52
e ISSN: 1941-2444
has issn l: 0148-6071
issue: 8
has NLM journal title abbreviation: JPEN J Parenter Enteral Nutr
publication name: JPEN. Journal of parenteral and enteral nutrition
language: eng
has national library of medicine journal id: 7804134
derived from: NLM
starting page: 1797
ending page: 1807
has place of publication: United States
has primary subject term: D000086382Q000150Q000628
has primary subject term: D044342Q000150
has subject term: D000328
has subject term: D006801
has subject term: D014481Q000453
has subject term: D006760
has subject term: D012121
has subject term: D015331
source: JPEN J Parenter Enteral Nutr. 2022-11;46(8):1797-1807.
volume: 46

The targeted high-risk case-finding approach versus universal screening for thyroid dysfunction during pregnancy: thyroid-stimulating hormone (TSH) and/or thyroid peroxidase antibody (TPOAb) test?
pmid: 35366161
abstract: To compare the effects of different thyroid screening scenarios, using the universal and targeted high-risk case-finding approaches with different diagnostic tests on the prevalence of subclinical hypothyroidism (SCH), thyroid autoimmunity, and pregnancy outcomes after adjustments for the intervention.During a secondary analysis of data collected in Tehran Thyroid and Pregnancy Study, a total of 2277 women from the total population, including 1303 high-risk individuals for thyroid dysfunction. The Cochran-Mantel-Haenszel method, adjusted for the intervention, was also used to evaluate the relationships between different screening scenarios [i.e., universal approach using thyroid-stimulating hormone (TSH) and/or thyroid peroxidase antibody (TPOAb) tests and targeted high-risk case-finding approach using TSH and/or TPOAb tests] and pregnancy outcomes (i.e., preterm delivery and NICU admission). The universal approach using both TSH and TPOAb measurements was considered as the reference scenario. We analyzed outcomes of different screening methods in individuals treated with LT4, compared to those individuals who were not treated.Compared to the universal screening approach with both TSH and TPOAb measurements, the targeted high-risk case-finding approach overlooked approximately 42%, 62%, and 74% of women with elevated TSH (> 4 µlU/mL) when using both TSH and TPOAb tests, TSH alone, and TPO alone, respectively. After adjusting for the missed cases, 2.86% of women with preterm delivery and 2.76% of women with NICU admission were missed when they were screened using the targeted high-risk case-finding approach by measuring both TSH and TPOAb. The percentage of missed cases increased when applying the targeted approach with the TSH test alone, without measuring TPOAb. Overall, 4.16% and 4.02% of women with preterm delivery and NICU admission were overlooked in this scenario, respectively. After adjustments for the intervention, the probability of NICU admission in neonat[cell cut: 2427 characters, first 2000 kept]
rights: © 2022. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).
has PII: 10.1007/s40618-021-01738-7
doi: 10.1007/s40618-021-01738-7
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Amiri M
      type: Person
      first name: M
      last name: Amiri
      member of: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran.
  slot:
    index: 2
    item: Nazarpour S
      type: Person
      first name: S
      last name: Nazarpour
      member of: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran.Department of Midwifery, Varamin-Pishva Branch, Islamic Azad University, Tehran, Iran.
  slot:
    index: 3
    item: Ramezani Tehrani F
      type: Person
      first name: F
      last name: Ramezani Tehrani
      member of: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran. fah.tehrani@gmail.com.
  slot:
    index: 4
    item: Sheidaei A
      type: Person
      first name: A
      last name: Sheidaei
      member of: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran.Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 5
    item: Azizi F
      type: Person
      first name: F
      last name: Azizi
      member of: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
created: 2022-4-3T06:00
date last updated: 2025-01-20
issued: 2022-09
dp: 2022 Sep
created: 2022-4-2T12:05
e ISSN: 1720-8386
has issn l: 0391-4097
issue: 9
has NLM journal title abbreviation: J Endocrinol Invest
publication name: Journal of endocrinological investigation
language: eng
has national library of medicine journal id: 7806594
derived from: NLM
starting page: 1641
ending page: 1651
has place of publication: Italy
has primary subject term: D007037Q000175
has primary subject term: D011248Q000175Q000188Q000453
has primary subject term: D047928Q000188
has primary subject term: D013959Q000175Q000188Q000453
has subject term: D001323
has subject term: D005260
has subject term: D006801
has subject term: D007231
has subject term: D007453
has subject term: D007492
has subject term: D011247
has subject term: D013972
has subject term: D013974Q000627
source: J Endocrinol Invest. 2022-09;45(9):1641-1651.
volume: 45

Developing and validating SARS-CoV-2 assays for nonhuman primate surveillance.
pmid: 35794847
abstract: In early 2020, the California National Primate Research Center implemented surveillance to address the threat of SARS-CoV-2 infection in its nonhuman primate colony.To detect antiviral antibodies, multi-antigen assays were developed and validated on enzyme immunoassay and multiplex microbead immunofluorescent assay (MMIA) platforms. To detect viral RNA, RT-PCR was also performed.Using a 4plex, antibody was identified in 16/16 experimentally infected animals; and specificity for spike, nucleocapsid, receptor binding domain, and whole virus antigens was 95.2%, 93.8%, 94.3%, and 97.1%, respectively on surveillance samples. Six laboratories compared this MMIA favorably with nine additional laboratory-developed or commercially available assays. Using a screen and confirm algorithm, 141 of the last 2441 surveillance samples were screen-reactive requiring confirmatory testing. Although 35 samples were reactive to either nucleocapsid or spike; none were reactive to both. Over 20 000 animals have been tested and no spontaneous infections have so far been confirmed across the NIH sponsored National Primate Research Centers.
rights: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
doi: 10.1111/jmp.12604
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Yee J
      type: Person
      first name: JoAnn
      last name: Yee
      member of: Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, Davis, California, USA.
  slot:
    index: 2
    item: Carpenter A
      type: Person
      first name: Amanda
      last name: Carpenter
      member of: Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, Davis, California, USA.
  slot:
    index: 3
    item: Nham P
      type: Person
      first name: Peter
      last name: Nham
      member of: Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, Davis, California, USA.
  slot:
    index: 4
    item: Halley B
      type: Person
      first name: Bryson
      last name: Halley
      member of: Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, Davis, California, USA.
  slot:
    index: 5
    item: Van Rompay KKA
      type: Person
      first name: Koen K A
      last name: Van Rompay
      member of: Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, Davis, California, USA.Department of Pathology, Microbiology & Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
  slot:
    index: 6
    item: Roberts J
      type: Person
      first name: Jeffrey
      last name: Roberts
      member of: Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, Davis, California, USA.Department Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
created: 2022-7-8T06:00
date last updated: 2025-01-20
issued: 2022-10
dp: 2022 10
created: 2022-7-7T01:53
e ISSN: 1600-0684
has issn l: 0047-2565
issue: 5
has NLM journal title abbreviation: J Med Primatol
publication name: Journal of medical primatology
language: eng
has national library of medicine journal id: 0320626
derived from: NLM
starting page: 264
ending page: 269
has place of publication: Denmark
has primary subject term: D000086382Q000175
has primary subject term: http://id.nlm.nih.gov/mesh/D000086402
has subject term: D000818
has subject term: D000914
has subject term: D012367
has subject term: D012680
source: J Med Primatol. 2022-10;51(5):264-269.
volume: 51

Short- and Long-Term Effects of Chlorpyrifos on Thyroid Hormone Axis and Brain Development in Xenopus laevis.
pmid: 35753306
abstract: The extensive use of the insecticide chlorpyrifos (CPF) throughout the world has brought increased scrutiny on its environmental and health impact. CPF is a cholinergic neurotoxicant; however, exposure to low noncholinergic doses is associated with numerous neurodevelopmental effects in animal models. In this study, we aimed to assess CPF for its potential to disrupt thyroid hormone signalling and investigate the short- and long-term effects on neurodevelopment by using Xenopus laevis.The thyroid hormone (TH) disrupting potential of CPF was assessed using TH-sensitive transgenic Tg(thibz:eGFP) tadpoles. The consequences of early embryonic exposure were examined by exposing fertilized eggs for 72 h to environmentally relevant CPF concentrations (10-10 M and 10-8 M). Three endpoints were evaluated: (1) gene expression in whole embryonic brains immediately after exposure, (2) mobility and brain morphology 1 week after exposure, and (3) brain morphology and axon diameters at the end of metamorphosis (2 months after the exposure).CPF disrupted TH signalling in Tg(thibz:eGFP) tadpoles. The expression of genes klf9, cntn4, oatp1c1, and tubb2b was downregulated in response to CPF. Tadpoles exposed to CPF exhibited increased mobility and altered brain morphology compared to control tadpoles. Early embryonic exposure of CPF affected myelinated axon diameter, with exposed animals exhibiting shifted frequency distributions of myelinated axons diameters towards smaller diameters in the hindbrain of froglets.This study provides more evidence of the endocrine and neurodevelopment disrupting activity of CPF. Further experimental and epidemiological studies are warranted to determine the long-term consequences of early CPF exposure on brain development.
rights: © 2022 S. Karger AG, Basel.
has PII: 000525719
doi: 10.1159/000525719
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Spirhanzlova P
      type: Person
      first name: Petra
      last name: Spirhanzlova
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.Unité Eco-Anthropologie, Hommes et Environnements, Muséum National d'Histoire Naturelle, Musée de l'Homme, Paris, France.Laboratoire de Métrologie et d'Essais, Paris, France.
  slot:
    index: 2
    item: Couderq S
      type: Person
      first name: Stephan
      last name: Couderq
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.
  slot:
    index: 3
    item: Le Mével S
      type: Person
      first name: Sébastian
      last name: Le Mével
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.
  slot:
    index: 4
    item: Leemans M
      type: Person
      first name: Michelle
      last name: Leemans
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.
  slot:
    index: 5
    item: Krief S
      type: Person
      first name: Sabrina
      last name: Krief
      member of: Unité Eco-Anthropologie, Hommes et Environnements, Muséum National d'Histoire Naturelle, Musée de l'Homme, Paris, France.
  slot:
    index: 6
    item: Mughal BB
      type: Person
      first name: Bilal B
      last name: Mughal
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.
  slot:
    index: 7
    item: Demeneix BA
      type: Person
      first name: Barbara A
      last name: Demeneix
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.
  slot:
    index: 8
    item: Fini JB
      type: Person
      first name: Jean-Baptiste
      last name: Fini
      member of: Unité PhyMA Laboratory, Adaptation du Vivant, Muséum National d'Histoire Naturelle, Paris, France.
created: 2022-6-27T06:00
date last updated: 2025-01-19
issued: 2023
dp: 2023
created: 2022-6-26T18:22
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 12
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1298
ending page: 1311
has place of publication: Switzerland
has primary subject term: D004390Q000633Q000378
has subject term: D000818
has subject term: D014982Q000378
has subject term: D013963
has subject term: D008675Q000502
has subject term: D001921Q000378
source: Neuroendocrinology. 2023;113(12):1298-1311.
volume: 113

The nasopharyngeal and salivary microbiomes in COVID-19 patients with and without asthma.
pmid: 35837881
doi: 10.1111/all.15438
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Kim JG
      type: Person
      first name: Josh G
      last name: Kim
      member of: Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  slot:
    index: 2
    item: Zhang A
      type: Person
      first name: Ai
      last name: Zhang
      member of: Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  slot:
    index: 3
    item: Rauseo AM
      type: Person
      first name: Adriana M
      last name: Rauseo
      member of: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  slot:
    index: 4
    item: Goss CW
      type: Person
      first name: Charles W
      last name: Goss
      member of: Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  slot:
    index: 5
    item: Mudd PA
      type: Person
      first name: Philip A
      last name: Mudd
      member of: Department of Emergency Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  slot:
    index: 6
    item: O'Halloran JA
      type: Person
      first name: Jane A
      last name: O'Halloran
      member of: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  slot:
    index: 7
    item: Wang L
      type: Person
      first name: Leyao
      last name: Wang
      member of: Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
created: 2022-7-16T06:00
date last updated: 2025-01-20
issued: 2022-12
dp: 2022 12
created: 2022-7-15T04:53
e ISSN: 1398-9995
has issn l: 0105-4538
issue: 12
has NLM journal title abbreviation: Allergy
publication name: Allergy
language: eng
has national library of medicine journal id: 7804028
derived from: NLM
starting page: 3676
ending page: 3679
has place of publication: Denmark
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has primary subject term: D064307
has primary subject term: D001249Q000175
has subject term: D006801
has subject term: D009305
has subject term: D012463
source: Allergy. 2022-12;77(12):3676-3679.
volume: 77

Identifying the Needs of Primary Care Providers Caring for Breast and Colon Cancer Survivors in the Safety-Net: a Qualitative Study.
pmid: 35829986
abstract: As the number of cancer survivors continues to increase and given the shortage of oncology clinicians in safety net health care settings, primary care providers (PCPs) in these settings will increasingly provide cancer survivorship care. In order to ensure equitable care for low-income and underserved breast and colon cancer survivors, it is essential to understand the safety-net PCPs' perspective. We conducted semi-structured, in-depth qualitative interviews with 11 PCPs working in a safety-net health care system to identify their needs in caring for cancer survivors. Interviews were audio-recorded and professionally transcribed. Two coders independently coded the interviews and conducted regular meetings until we reached consensus on the results. Analysis was based in grounded theory and performed using the constant comparative method. Thematic analysis identified six themes as follows: (1) Cancer survivorship care can be integrated with the whole person and chronic disease care management that occurs in primary care; (2) PCPs' perceptions regarding patients' survivorship care needs and their confidence in meeting those needs; (3) preference for a shared care model; (4) coordination of care; (5) PCPs' need for survivorship care education and training; and (6) unique issues involved in the care of older cancer survivors. PCPs in the safety-net believe that providing comprehensive survivorship care requires coordination of care through the cancer continuum. Tools like checklists, electronic health records-based communication, and convenient electronic consultations with cancer specialists would enhance the quality of survivorship care. Respondents advocate the inclusion of survivorship care education in medical education. The continuity of care with PCPs means that they play a particularly important role in the care of older cancer survivors.
rights: © 2022. The Author(s).
has PII: 10.1007/s13187-022-02195-3
doi: 10.1007/s13187-022-02195-3
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Dixit N
      type: Person
      first name: Niharika
      last name: Dixit
      member of: Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Niharika.dixit@ucsf.edu.
  slot:
    index: 2
    item: Rodriguez G
      type: Person
      first name: Gladys
      last name: Rodriguez
      member of: Hematology/Oncology, Stanford School of Medicine, Palo Alto, CA, USA.
  slot:
    index: 3
    item: Sarkar U
      type: Person
      first name: Urmimala
      last name: Sarkar
      member of: Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.Center for Vulnerable Populations, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 4
    item: Burke N
      type: Person
      first name: Nancy
      last name: Burke
      member of: School of Social Sciences, Humanities, and Arts, University of California Merced, Merced, CA, USA.
  slot:
    index: 5
    item: Trejo E
      type: Person
      first name: Evelin
      last name: Trejo
      member of: Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 6
    item: Devore DJ
      type: Person
      first name: Denise Joanna
      last name: Devore
      member of: , Selby Lane, Redwood City, CA, USA.
  slot:
    index: 7
    item: Couey P
      type: Person
      first name: Paul
      last name: Couey
      member of: Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 8
    item: Nápoles AM
      type: Person
      first name: Anna María
      last name: Nápoles
      member of: Division of Intramural Research, National Institute On Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
created: 2022-7-14T06:00
date last updated: 2025-01-20
issued: 2023-06
dp: 2023 06
created: 2022-7-13T11:24
e ISSN: 1543-0154
has issn l: 0885-8195
issue: 3
has NLM journal title abbreviation: J Cancer Educ
publication name: Journal of cancer education : the official journal of the American Association for Cancer Education
language: eng
has national library of medicine journal id: 8610343
derived from: NLM
starting page: 845
ending page: 853
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000073116
has primary subject term: D058007
has primary subject term: D003110Q000628
has subject term: D006801
has subject term: D011320
source: J Cancer Educ. 2023-06;38(3):845-853.
volume: 38

Daily and average associations of physical activity, social media use, and sleep among adolescent girls during the COVID-19 pandemic.
pmid: 35535484
abstract: Adolescents' daily lives have been disrupted during the Coronavirus disease 2019 (COVID-19) pandemic. It remains unclear how changes in adolescents' daily physical and social behaviours affect their sleep. The present study examined the daily and average effects of physical activity and social media use (i.e., video chatting, texting, and social networking sites) on adolescent girls' sleep during the COVID-19 pandemic. Adolescent girls aged 12-17 years (N = 93; 69% White) from a larger longitudinal study completed a 10-day daily diary protocol during state-mandated stay-at-home orders. Girls reported on daily sleep (duration, timing, quality), physical activity, and social media use during COVID-19. Multilevel modelling was used to examine the within- and between-person effects of physical activity and social media on sleep duration, timing, and quality during the 10-day period. Between-person associations indicate that youth with greater social media use (texting, video chatting, and social networking) and less physical activity had later sleep timing across the 10-day study period. Only video chatting was associated with shorter sleep duration. There were no within-person effects of physical activity or social media activities on sleep outcomes. Findings indicate that physical activity and social media use may impact later adolescent sleep timing during the COVID-19 pandemic. It will be critical for research to examine the potential long-term costs of delayed sleep timing, and whether targeting specific youth behaviours associated with sleep and circadian disruption improve mental and physical health during the COVID-19 pandemic and beyond.
rights: © 2022 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
doi: 10.1111/jsr.13611
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Hamilton JL
      type: Person
      first name: Jessica L
      last name: Hamilton
      member of: Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA.
  slot:
    index: 2
    item: Hutchinson E
      type: Person
      first name: Emily
      last name: Hutchinson
      member of: Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  slot:
    index: 3
    item: Evankovich MR
      type: Person
      first name: Maria R
      last name: Evankovich
      member of: Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  slot:
    index: 4
    item: Ladouceur CD
      type: Person
      first name: Cecile D
      last name: Ladouceur
      member of: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  slot:
    index: 5
    item: Silk JS
      type: Person
      first name: Jennifer S
      last name: Silk
      member of: Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
created: 2022-5-11T06:00
date last updated: 2025-01-20
issued: 2023-02
dp: 2023 02
created: 2022-5-10T03:44
e ISSN: 1365-2869
has issn l: 0962-1105
issue: 1
has NLM journal title abbreviation: J Sleep Res
publication name: Journal of sleep research
language: eng
has national library of medicine journal id: 9214441
derived from: NLM
pg: e13611
has place of publication: England
has primary subject term: D061108
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has subject term: D005260
has subject term: D006801
has subject term: D000293
has subject term: D058873
has subject term: D008137
has subject term: D012890
has subject term: D015444
source: J Sleep Res. 2023-02;32(1):e13611.
volume: 32

Exposure to either Bisphenol A or S Represents a Risk for Crucial Behaviors for Pup Survival, Such as Spontaneous Maternal Behavior in Mice.
pmid: 35850097
abstract: Maternal behavior depends on a multitude of factors, including environmental ones, such as Endocrine Disrupting Chemicals (EDCs), which are increasingly attracting attention. Bisphenol A (BPA), an EDC present in plastic, is known to exert negative effects on maternal behavior. Bisphenol S (BPS), a BPA substitute, seems to share some endocrine disrupting properties. In this study, we focused on the analysis of the effects of low-dose (i.e., 4 µg/kg body weight/day, EFSA TDI for BPA) BPA or BPS exposure throughout pregnancy and lactation in mice.We administered adult C57BL/6 J females orally BPA, BPS, or vehicle from mating to offspring weaning. We assessed the number of pups at birth, the sex ratio, and the percentage of dead pups in each litter, and during the first postnatal week, we observed spontaneous maternal behavior. At the weaning of the pups, we sacrificed the dams and analyzed the oxytocin system, known to be involved in the control of maternal care, in the hypothalamic magnocellular nuclei.At birth, pups from BPA-treated dams tended to have a lower male-to-female ratio compared to controls, while the opposite was observed among BPS-treated dams' litters. During the first postnatal week, offspring mortality impacted differentially in the BPA and BPS litters, with more female dead pups among the BPA litters, while more male dead pups in the BPS litters, sharpening the difference in the sex ratio. BPA- and BPS-treated dams spent significantly less time in pup-related behaviors than controls. Oxytocin immunoreactivity in the paraventricular and supraoptic nuclei was increased only in the BPA-treated dams.Alterations in maternal care, along with the treatment itself, may affect, later in life, the offspring's physiology and behavior. Exposure to BPs during sensitive developmental periods represents a risk for both dams and offspring, even at low environmentally relevant doses, through the functional alteration of neural circuits controlling fundamental behavio[cell cut: 2048 characters, first 2000 kept]
rights: © 2022 S. Karger AG, Basel.
has PII: 000526074
doi: 10.1159/000526074
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Bonaldo B
      type: Person
      first name: Brigitta
      last name: Bonaldo
      member of: Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, Turin, Italy.Department of Neuroscience Rita Levi-Montalcini, University of Turin, Turin, Italy.
  slot:
    index: 2
    item: Gioiosa L
      type: Person
      first name: Laura
      last name: Gioiosa
      member of: Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, Parma, Italy.
  slot:
    index: 3
    item: Panzica G
      type: Person
      first name: GianCarlo
      last name: Panzica
      member of: Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, Turin, Italy.Department of Neuroscience Rita Levi-Montalcini, University of Turin, Turin, Italy.
  slot:
    index: 4
    item: Marraudino M
      type: Person
      first name: Marilena
      last name: Marraudino
      member of: Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole, Turin, Italy.Department of Neuroscience Rita Levi-Montalcini, University of Turin, Turin, Italy.
created: 2022-7-20T06:00
date last updated: 2025-01-19
issued: 2023
dp: 2023
created: 2022-7-19T07:20
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 12
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1283
ending page: 1297
has place of publication: Switzerland
has primary subject term: D011297Q000139
has subject term: D011247
has subject term: D006801
has subject term: D051379
has subject term: D000818
has subject term: D008297
has subject term: D005260
has subject term: D010121Q000494
has subject term: D008810
has subject term: D008425
source: Neuroendocrinology. 2023;113(12):1283-1297.
volume: 113

An assessment of urethral radiation exposure in the treatment of endometrial and rectal cancers.
pmid: 36181547
abstract: Female survivors of endometrial and rectal cancers have increased risk of urinary incontinence. Survivors with prior radiation therapy are counseled against mesh incontinence surgery. We hypothesize that urethral radiation dose varies based on modality which may influence surgical risks. We aimed to demonstrate urethral radiation dose differences between vaginal brachytherapy (VBT) and external beam radiation therapy (EBRT).This is a retrospective cohort study of women exposed to VBT for endometrial cancer and EBRT for rectal cancer. The urethra was contoured on CT imaging to calculate radiation doses in centigray (cGy). The primary outcome was the percent of treatment radiation dose estimated to be received by the urethra based on the volume dose to 0.2 cc of urethra. Secondary outcomes were point doses to the bladder neck, mid-urethra, and total mean urethral dose. Descriptive statistics described demographic characteristics. Bivariate analyses compared urethral radiation dose based on radiation modality.Between 2014-2017, 32 women treated were included: 18 with VBT and 14 with EBRT. Mean ± SD urethral volume doses were lower in VBT (1266 cGy ± 533, 42.2% of prescribed treatment dose) compared to EBRT (5051 cGy ± 192, 100.2% of prescribed treatment dose), p < 0.0001. VBT also had significantly lower mean total urethral dose and point doses to bladder neck and mid- urethra compared to EBRT (p < 0.0001).The female urethra is exposed to significantly less radiation in VBT compared to EBRT. These data highlight that modality of pelvic radiation should be considered in treatment counseling on urinary incontinence in women.
rights: © 2022. The International Urogynecological Association.
has PII: 10.1007/s00192-022-05363-7
doi: 10.1007/s00192-022-05363-7
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Hines K
      type: Person
      first name: Katherine
      last name: Hines
      member of: Wake Forest Department of Urology, Division of Female Pelvic Health, Winston-Salem, NC, USA.
  slot:
    index: 2
    item: Nieto K
      type: Person
      first name: Karina
      last name: Nieto
      member of: Wake Forest Department of Radiation Oncology, Winston-Salem, NC, USA.
  slot:
    index: 3
    item: Dezarn W
      type: Person
      first name: William
      last name: Dezarn
      member of: Wake Forest Department of Radiation Oncology, Winston-Salem, NC, USA.
  slot:
    index: 4
    item: Greven K
      type: Person
      first name: Kathryn
      last name: Greven
      member of: Wake Forest Department of Radiation Oncology, Winston-Salem, NC, USA.
  slot:
    index: 5
    item: Krol B
      type: Person
      first name: Bridget
      last name: Krol
      member of: Wake Forest School of Medicine, Winston-Salem, NC, USA.
  slot:
    index: 6
    item: Matthews C
      type: Person
      first name: Catherine
      last name: Matthews
      member of: Wake Forest Department of Urology, Division of Female Pelvic Health, Winston-Salem, NC, USA.
  slot:
    index: 7
    item: Parker-Autry C
      type: Person
      first name: Candace
      last name: Parker-Autry
      member of: Wake Forest Department of Urology, Division of Female Pelvic Health, Winston-Salem, NC, USA. cparkera@wakehealth.edu.
created: 2022-10-2T06:00
date last updated: 2025-01-20
issued: 2023-04
dp: 2023 04
created: 2022-10-1T11:14
e ISSN: 1433-3023
has issn l: 0937-3462
issue: 4
has NLM journal title abbreviation: Int Urogynecol J
publication name: International urogynecology journal
language: eng
has national library of medicine journal id: 101567041
derived from: NLM
starting page: 929
ending page: 935
has place of publication: England
has primary subject term: D016889Q000601
has primary subject term: http://id.nlm.nih.gov/mesh/D000069079
has primary subject term: D012004
has primary subject term: D014549
has subject term: D006801
has subject term: D005260
has subject term: D014521Q000000981
has subject term: D012189
source: Int Urogynecol J. 2023-04;34(4):929-935.
volume: 34

Inhibition of MEK signaling prevents SARS-CoV2-induced lung damage and improves the survival of infected mice.
pmid: 36030555
abstract: Coronavirus disease 2019 (COVID-19) is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Over 500 million confirmed cases of COVID-19 have been recorded, with six million deaths. Thus, reducing the COVID-19-related medical burden is an unmet need. Despite a vaccine that is successful in preventing COVID-19-caused death, effective medication to relieve COVID-19-associated symptoms and alleviate disease progression is still in high demand. In particular, one in three COVID-19 patients have signs of long COVID syndrome and are termed, long haulers. At present, there are no effective ways to treat long haulers. In this study, we determine the effectiveness of inhibiting mitogen-activated protein kinase (MEK) signaling in preventing SARS-CoV-2-induced lung damage in mice. We showed that phosphorylation of extracellular signal-regulated kinase, a marker for MEK activation, is high in SARS-CoV-2-infected lung tissues of mice and humans. We also showed that selumetinib, a specific inhibitor of the upstream MEK kinases, reduces cell proliferation, reduces lung damage following SARS-CoV-2 infection, and prolongs the survival of the infected mice. Selumetinib has been approved by the US Food and Drug Administration to treat cancer. Further analysis indicates that amphiregulin, an essential upstream molecule, was upregulated following SARS-CoV-2 infection. Our data suggest that MEK signaling activation represents a target for therapeutic intervention strategies against SARS-CoV-2-induced lung damage and that selumetinib may be repurposed to treat COVID-19.
rights: © 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
doi: 10.1002/jmv.28094
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Xie J
      type: Person
      first name: Jingwu
      last name: Xie
      member of: Department of Pediatrics, The Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 2
    item: Klemsz MJ
      type: Person
      first name: Michael J
      last name: Klemsz
      member of: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 3
    item: Kacena MA
      type: Person
      first name: Melissa A
      last name: Kacena
      member of: Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 4
    item: Sandusky G
      type: Person
      first name: George
      last name: Sandusky
      member of: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 5
    item: Zhang X
      type: Person
      first name: Xiaoli
      last name: Zhang
      member of: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  slot:
    index: 6
    item: Kaplan MH
      type: Person
      first name: Mark H
      last name: Kaplan
      member of: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
created: 2022-8-29T06:00
date last updated: 2025-01-20
issued: 2022-12
dp: 2022 12
created: 2022-8-28T17:00
e ISSN: 1096-9071
has issn l: 0146-6615
issue: 12
has NLM journal title abbreviation: J Med Virol
publication name: Journal of medical virology
language: eng
has national library of medicine journal id: 7705876
derived from: NLM
starting page: 6097
ending page: 6102
has place of publication: United States
has primary subject term: D000086382Q000150
has primary subject term: http://id.nlm.nih.gov/mesh/D000093485
has subject term: D066258
has subject term: D048049
has subject term: D006801
has subject term: D008168
has subject term: D020930
has subject term: D020929Q000235
has subject term: D012367
has subject term: http://id.nlm.nih.gov/mesh/D000086402
has subject term: http://id.nlm.nih.gov/mesh/D000094024
source: J Med Virol. 2022-12;94(12):6097-6102.
volume: 94

Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children.
pmid: 35932217
doi: 10.1002/ppul.26091
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Gourari I
      type: Person
      first name: Ioulia
      last name: Gourari
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 2
    item: Gomi R
      type: Person
      first name: Rika
      last name: Gomi
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 3
    item: Young M
      type: Person
      first name: Madeline
      last name: Young
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 4
    item: Jordan G
      type: Person
      first name: Geancarlo
      last name: Jordan
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 5
    item: Liongson M
      type: Person
      first name: Madeline
      last name: Liongson
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 6
    item: Heras A
      type: Person
      first name: Andrea
      last name: Heras
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 7
    item: Gerber LM
      type: Person
      first name: Linda M
      last name: Gerber
      member of: Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 8
    item: Thomas C
      type: Person
      first name: Charlene
      last name: Thomas
      member of: Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 9
    item: Tsirilakis K
      type: Person
      first name: Kalliope
      last name: Tsirilakis
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 10
    item: Ono J
      type: Person
      first name: Jennie
      last name: Ono
      member of: Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 11
    item: Narula P
      type: Person
      first name: Pramod
      last name: Narula
      member of: Department of Pediatrics, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.
  slot:
    index: 12
    item: Ketas T
      type: Person
      first name: Thomas
      last name: Ketas
      member of: Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 13
    item: Moore JP
      type: Person
      first name: John P
      last name: Moore
      member of: Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 14
    item: Worgall S
      type: Person
      first name: Stefan
      last name: Worgall
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.Drukier Institute for Children's Health, Weill Cornell Medicine, New York, New York, USA.Department of Genetic Medicine, Weill Cornell Medicine, New York, New York, USA.
  slot:
    index: 15
    item: Permaul P
      type: Person
      first name: Perdita
      last name: Permaul
      member of: Division of Pediatric Pulmonology, Allergy & Immunology, Weill Cornell Medicine, New York, New York, USA.Drukier Institute for Children's Health, Weill Cornell Medicine, New York, New York, USA.
created: 2022-8-7T06:00
date last updated: 2025-01-20
issued: 2022-11
dp: 2022 11
created: 2022-8-6T08:02
e ISSN: 1099-0496
has issn l: 1099-0496
issue: 11
has NLM journal title abbreviation: Pediatr Pulmonol
publication name: Pediatric pulmonology
language: eng
has national library of medicine journal id: 8510590
derived from: NLM
starting page: 2855
ending page: 2860
has place of publication: United States
has primary subject term: D001249Q000235
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has subject term: D002648
has subject term: D020022
has subject term: D006801
has subject term: D012307
source: Pediatr Pulmonol. 2022-11;57(11):2855-2860.
volume: 57

Gabapentin improves parosmia after COVID-19 infection.
pmid: 36484400
doi: 10.1002/alr.23117
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Garcia JAP
      type: Person
      first name: Jaime A Pena
      last name: Garcia
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 2
    item: Miller E
      type: Person
      first name: Emily
      last name: Miller
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 3
    item: Norwood TG
      type: Person
      first name: Timothy G
      last name: Norwood
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 4
    item: Dorin NA
      type: Person
      first name: Natalie A
      last name: Dorin
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 5
    item: Grayson J
      type: Person
      first name: Jessica
      last name: Grayson
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 6
    item: Woodworth B
      type: Person
      first name: Bradford
      last name: Woodworth
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 7
    item: Cho DY
      type: Person
      first name: Do-Yeon
      last name: Cho
      member of: Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.Division of Otolaryngology, Department of Surgery, Veterans Affairs, Birmingham, Alabama, USA.
created: 2022-12-10T06:00
date last updated: 2025-01-20
issued: 2023-06
dp: 2023 06
created: 2022-12-9T06:34
e ISSN: 2042-6984
has issn l: 2042-6976
issue: 6
has NLM journal title abbreviation: Int Forum Allergy Rhinol
publication name: International forum of allergy & rhinology
language: eng
has national library of medicine journal id: 101550261
derived from: NLM
starting page: 1034
ending page: 1036
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has primary subject term: D000857
has subject term: D006801
has subject term: D000077206Q000627
has subject term: D012903
source: Int Forum Allergy Rhinol. 2023-06;13(6):1034-1036.
volume: 13

Induction of Oxidative Stress and Alteration of Synaptic Gene Expression in Newborn Hippocampal Granule Cells after Developmental Exposure to Aroclor 1254.
pmid: 36257292
abstract: Hippocampal newborn neurons integrate into functional circuits where they play an important role in learning and memory. We previously showed that perinatal exposure to Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs) associated with alterations of cognitive function in children, disrupted the normal maturation of excitatory synapses in the dentate gyrus. We hypothesized that hippocampal immature neurons underlie some of the cognitive effects of PCBs.We used newly generated neurons to examine the effects of PCBs in mice following maternal exposure. Newborn dentate granule cells were tagged with enhanced green fluorescent protein using a transgenic mouse line. The transcriptome of the newly generated granule cells was assessed using RNA sequencing.Gestational and lactational exposure to 6 mg/kg/day of Aroclor 1254 disrupted the mRNA expression of 1,308 genes in newborn granule cells. Genes involved in mitochondrial functions were highly enriched with 154 genes significantly increased in exposed compared to control mice. The upregulation of genes involved in oxidative phosphorylation was accompanied by signs of endoplasmic reticulum stress and an increase in lipid peroxidation, a marker of oxidative stress, in the subgranular zone of the dentate gyrus but not in mature granule cells in the granular zone. Aroclor 1254 exposure also disrupted the expression of synaptic genes. Using laser-captured subgranular and granular zones, this effect was restricted to the subgranular zone, where newborn neurons are located.Our data suggest that gene expression in newborn granule cells is disrupted by Aroclor 1254 and provide clues to the effects of endocrine-disrupting chemicals on the brain.
rights: © 2022 S. Karger AG, Basel.
has PII: 000527576
doi: 10.1159/000527576
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Pinson A
      type: Person
      first name: Anneline
      last name: Pinson
      member of: Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Liège, Belgium.
  slot:
    index: 2
    item: Sevrin E
      type: Person
      first name: Elena
      last name: Sevrin
      member of: Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Liège, Belgium.
  slot:
    index: 3
    item: Chatzi C
      type: Person
      first name: Christina
      last name: Chatzi
      member of: Vollum Institute, Oregon Health and Science University, Portland, Oregon, USA.
  slot:
    index: 4
    item: Le Gac B
      type: Person
      first name: Benjamin
      last name: Le Gac
      member of: Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Liège, Belgium.
  slot:
    index: 5
    item: Thiry M
      type: Person
      first name: Marc
      last name: Thiry
      member of: Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium.
  slot:
    index: 6
    item: Westbrook GL
      type: Person
      first name: Gary L
      last name: Westbrook
      member of: Vollum Institute, Oregon Health and Science University, Portland, Oregon, USA.
  slot:
    index: 7
    item: Parent AS
      type: Person
      first name: Anne-Simone
      last name: Parent
      member of: Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Liège, Belgium.
created: 2022-10-19T06:00
date last updated: 2025-01-19
issued: 2023
dp: 2023
created: 2022-10-18T18:30
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 12
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1248
ending page: 1261
has place of publication: Switzerland
has primary subject term: D011078Q000494
has subject term: D006801
has subject term: D005260
has subject term: D011247
has subject term: D002648
has subject term: D051379
has subject term: D000818
has subject term: D020111Q000633
has subject term: D006624
has subject term: D009474Q000502
has subject term: D008822
has subject term: D001921
has subject term: D018384
has subject term: D015870
has subject term: D018891
has subject term: D055495
source: Neuroendocrinology. 2023;113(12):1248-1261.
volume: 113

Impacts of Gestational FireMaster 550 Exposure on the Neonatal Cortex Are Sex Specific and Largely Attributable to the Organophosphate Esters.
pmid: 36075192
abstract: Flame retardants (FRs) are common bodily and environmental pollutants, creating concern about their potential toxicity. We and others have found that the commercial mixture FireMaster® 550 (FM 550) or its individual brominated (BFR) and organophosphate ester (OPFR) components are potential developmental neurotoxicants. Using Wistar rats, we previously reported that developmental exposure to FM 550 or its component classes produced sex- and compound-specific effects on adult socioemotional behaviors. The underlying mechanisms driving the behavioral phenotypes are unknown.To further mechanistic understanding, here we conducted transcriptomics in parallel with a novel lipidomics approach using cortical tissues from newborn siblings of the rats in the published behavioral study. Inclusion of lipid composition is significant because it is rarely examined in developmental neurotoxicity studies. Pups were gestationally exposed via oral dosing to the dam to FM 550 or the BFR or OPFR components at environmentally relevant doses.The neonatal cortex was highly sexually dimorphic in lipid and transcriptome composition, and males were more significantly impacted by FR exposure. Multiple adverse modes of action for the BFRs and OPFRs on neurodevelopment were identified, with the OPFRs being more disruptive than the BFRs via multiple mechanisms including dysregulation of mitochondrial function and disruption of cholinergic and glutamatergic systems. Disrupted mitochondrial function by environmental factors has been linked to a higher risk of autism spectrum disorders and neurodegenerative disorders. Impacted lipid classes included ceramides, sphingomyelins, and triacylglycerides. Robust ceramide upregulation in the OPFR females could suggest a heightened risk of brain metabolic disease.This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern.
rights: © 2022 S. Karger AG, Basel.
has PII: 000526959
doi: 10.1159/000526959
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Witchey SK
      type: Person
      first name: Shannah K
      last name: Witchey
      member of: Department of Biological Sciences, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 2
    item: Doyle MG
      type: Person
      first name: Michael G
      last name: Doyle
      member of: Department of Chemistry, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 3
    item: Fredenburg JD
      type: Person
      first name: Jacob D
      last name: Fredenburg
      member of: Department of Biological Sciences, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 4
    item: St Armour G
      type: Person
      first name: Genevieve
      last name: St Armour
      member of: Department of Biological Sciences, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 5
    item: Horman B
      type: Person
      first name: Brian
      last name: Horman
      member of: Department of Biological Sciences, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 6
    item: Odenkirk MT
      type: Person
      first name: Melanie T
      last name: Odenkirk
      member of: Department of Chemistry, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 7
    item: Aylor DL
      type: Person
      first name: David L
      last name: Aylor
      member of: Department of Biological Sciences, NC State University, Raleigh, North Carolina, USA.Center for Human Health and the Environment, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 8
    item: Baker ES
      type: Person
      first name: Erin S
      last name: Baker
      member of: Department of Chemistry, NC State University, Raleigh, North Carolina, USA.
  slot:
    index: 9
    item: Patisaul HB
      type: Person
      first name: Heather B
      last name: Patisaul
      member of: Center for Human Health and the Environment, NC State University, Raleigh, North Carolina, USA.
created: 2022-9-9T06:00
date last updated: 2025-01-19
issued: 2023
dp: 2023
created: 2022-9-8T18:22
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 12
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1262
ending page: 1282
has place of publication: Switzerland
has primary subject term: D011075
has primary subject term: D005411Q000633
has subject term: D008297
has subject term: D005260
has subject term: D051381
has subject term: D000818
has subject term: D017208
has subject term: D010755Q000633
has subject term: D008055
source: Neuroendocrinology. 2023;113(12):1262-1282.
volume: 113

Dual impacts of Medicare payment reform and the COVID-19 pandemic on therapy staffing in skilled nursing facilities.
pmid: 36571515
abstract: Implementation of new skilled nursing facility (SNF) Medicare payment policy, the Patient Driven Payment Model (PDPM), resulted in immediate declines in physical and occupational therapy staffing. This study characterizes continuing impacts of PDPM in conjunction with COVID-19 on SNF therapy staffing and examines variability in staffing changes based on SNF organizational characteristics.We analyzed Medicare administrative data from a national cohort of SNFs between January 2019 and March 2022. Interrupted time series mixed effects regression examined changes in level and trend of total therapy staffing minutes/patient-day during PDPM and COVID-19 and by type of staff (therapists, assistants, contractors, and in-house staff). Secondary analyses examined the variability in staffing by organizational characteristics.PDPM resulted in a -6.54% level change in total therapy staffing, with larger declines for assistants and contractors. Per-patient staffing fluctuated during COVID-19 as the census changed. PDPM-related staffing declines were larger in SNFs that were: Rural, for-profit, chain-affiliated, provided more intensive therapy, employed more therapy assistants, and admitted more Medicare patients before PDPM. COVID-19 resulted in larger staffing declines in rural SNFs but smaller early declines in SNFs that were hospital-based, for-profit, or received more relief funding.SNFs that historically engaged in profit-maximizing behaviors (e.g., providing more therapy via lower-paid assistants) had larger staffing declines during PDPM compared to other SNFs. Therapy staffing fluctuated during COVID-19, but PDPM-related reductions persisted 2 years into the pandemic, especially in rural SNFs. Results suggest specific organizational characteristics that should be targeted for staffing and quality improvement initiatives.
rights: © 2022 The American Geriatrics Society.
doi: 10.1111/jgs.18208
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Prusynski RA
      type: Person
      first name: Rachel A
      last name: Prusynski
      member of: Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
  slot:
    index: 2
    item: Humbert A
      type: Person
      first name: Andrew
      last name: Humbert
      member of: Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.
  slot:
    index: 3
    item: Leland NE
      type: Person
      first name: Natalie E
      last name: Leland
      member of: Department of Occupational Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  slot:
    index: 4
    item: Frogner BK
      type: Person
      first name: Bianca K
      last name: Frogner
      member of: Center for Health Workforce Studies, Department of Family Medicine, University of Washington, Seattle, Washington, USA.
  slot:
    index: 5
    item: Saliba D
      type: Person
      first name: Debra
      last name: Saliba
      member of: UCLA Borun Center, University of California Los Angeles, Los Angeles, California, USA.Geriatric Research Education & Clinical Center, VA Geriatric Research Education and Clinical Center, Los Angeles, California, USA.RAND Corporation, Santa Monica, California, USA.
  slot:
    index: 6
    item: Mroz TM
      type: Person
      first name: Tracy M
      last name: Mroz
      member of: Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA.Center for Health Workforce Studies, Department of Family Medicine, University of Washington, Seattle, Washington, USA.
created: 2022-12-27T06:00
date last updated: 2025-01-20
issued: 2023-02
dp: 2023 02
created: 2022-12-26T09:42
e ISSN: 1532-5415
has issn l: 0002-8614
issue: 2
has NLM journal title abbreviation: J Am Geriatr Soc
publication name: Journal of the American Geriatrics Society
language: eng
has national library of medicine journal id: 7503062
derived from: NLM
starting page: 609
ending page: 619
has place of publication: United States
has primary subject term: D006278
has primary subject term: D000086382Q000453
has subject term: D000368
has subject term: D006801
has subject term: D014481Q000453
has subject term: D012866
has subject term: D058873
has subject term: http://id.nlm.nih.gov/mesh/D000078329
source: J Am Geriatr Soc. 2023-02;71(2):609-619.
volume: 71

Choosing the right chronic medication for hemodialysis patients. A short ABC for the dialysis nephrologist.
pmid: 36472789
abstract: Adapting drug treatments for patients on hemodialysis with multiple chronic pathologies is a complex affair. When prescribing a medication, the risk-benefit analysis usually focuses primarily on the indication of the drug class prescribed. However, the pharmacokinetics of the chosen drug should also be taken into account. The purpose of our review was to identify the drugs to be favored in each therapeutic class, according to their safety and pharmacokinetic profiles, for the most common chronic diseases in patients on chronic hemodialysis.We conducted a narrative review of the literature using Medline and Web of Science databases, targeting studies on the most commonly-prescribed drugs for non-communicable diseases in patients on chronic hemodialysis.The search identified 1224 articles, 95 of which were further analyzed. The main classes of drugs included concern the cardiovascular system (anti-hypertensives, anti-arrhythmics, anti-thrombotics, hypocholesterolemics), the endocrine and metabolic pathways (anti-diabetics, gastric anti-secretory, anticoagulant, thyroid hormones, anti-gout) and psychiatric and neurological disorders (antidepressants, anxiolytics, antipsychotics and anti-epileptics).We report on the most often prescribed drugs for chronic pathologies in patients on chronic hemodialysis. Most of them require adaptation, and in some cases one better alternative stands out among the drug class. More pharmacokinetic data are needed to define the pharmacokinetics in the various dialysis techniques.
rights: © 2022. The Author(s) under exclusive licence to Italian Society of Nephrology.
has PII: 10.1007/s40620-022-01477-9
doi: 10.1007/s40620-022-01477-9
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Roux C
      type: Person
      first name: Clarisse
      last name: Roux
      member of: Service Pharmacie, Hopital Universitaire de Nimes, CHU Carémeau, Nîmes, France. Clarisse.roux@chu-nimes.fr.Institut Desbrest d'Epidemiologie et Santé publique (IDESP), INSERM, Montpellier, France. Clarisse.roux@chu-nimes.fr.
  slot:
    index: 2
    item: Verollet K
      type: Person
      first name: Kristelle
      last name: Verollet
      member of: Service Pharmacie, Hopital Universitaire de Nimes, CHU Carémeau, Nîmes, France.
  slot:
    index: 3
    item: Prouvot J
      type: Person
      first name: Julien
      last name: Prouvot
      member of: Institut Desbrest d'Epidemiologie et Santé publique (IDESP), INSERM, Montpellier, France.Service Néphrologie Dialyse Apherese, Hopital Universitaire de Nimes, CHU Carémeau, Nîmes, France.
  slot:
    index: 4
    item: Prelipcean C
      type: Person
      first name: Camelia
      last name: Prelipcean
      member of: Service Néphrologie Dialyse Apherese, Hopital Universitaire de Nimes, CHU Carémeau, Nîmes, France.
  slot:
    index: 5
    item: Pambrun E
      type: Person
      first name: Emilie
      last name: Pambrun
      member of: Service Néphrologie Dialyse Apherese, Hopital Universitaire de Nimes, CHU Carémeau, Nîmes, France.
  slot:
    index: 6
    item: Moranne O
      type: Person
      first name: Olivier
      last name: Moranne
      member of: Institut Desbrest d'Epidemiologie et Santé publique (IDESP), INSERM, Montpellier, France. olivier.moranne@chu-nimes.fr.Service Néphrologie Dialyse Apherese, Hopital Universitaire de Nimes, CHU Carémeau, Nîmes, France. olivier.moranne@chu-nimes.fr.
created: 2022-12-7T06:00
date last updated: 2025-01-20
issued: 2023-03
dp: 2023 03
created: 2022-12-6T11:19
e ISSN: 1724-6059
has issn l: 1121-8428
issue: 2
has NLM journal title abbreviation: J Nephrol
publication name: Journal of nephrology
language: eng
has national library of medicine journal id: 9012268
derived from: NLM
starting page: 521
ending page: 536
has place of publication: Italy
has primary subject term: D006435Q000009
has primary subject term: http://id.nlm.nih.gov/mesh/D000072104
has subject term: D006801
has subject term: D000928
source: J Nephrol. 2023-03;36(2):521-536.
volume: 36

De novo emergence of SARS-CoV-2 spike mutations in immunosuppressed patients.
pmid: 35899968
abstract: The continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with decreased susceptibility to neutralizing antibodies is of clinical importance. Several spike mutations associated with immune escape have evolved independently in association with different variants of concern (VOCs). How and when these mutations arise is still unclear. We hypothesized that such mutations might arise in the context of persistent viral replication in immunosuppressed hosts.Nasopharyngeal specimens were collected longitudinally from two immunosuppressed patients with persistent SARS-CoV-2 infection. Plasma was collected from these same patients late in disease course. SARS-CoV-2 whole genome sequencing was performed to assess the emergence and frequency of mutations over time. Select Spike mutations were assessed for their impact on viral entry and antibody neutralization in vitro.Our sequencing results revealed the intrahost emergence of spike mutations that are associated with circulating VOCs in both immunosuppressed patients (del241-243 and E484Q in one patient, and E484K in the other). These mutations decreased antibody-mediated neutralization of pseudotyped virus particles in cell culture, but also decreased efficiency of spike-mediated cell entry.These observations demonstrate the de novo emergence of SARS-CoV-2 spike mutations with enhanced immune evasion in immunosuppressed patients with persistent infection. These data suggest one potential mechanism for the evolution of VOCs and emphasize the importance of continued efforts to develop antiviral drugs for suppression of viral replication in hospitalized settings.
rights: © 2022 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC.
doi: 10.1111/tid.13914
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Simons LM
      type: Person
      first name: Lacy M
      last name: Simons
      member of: Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, Illinois, USA.
  slot:
    index: 2
    item: Ozer EA
      type: Person
      first name: Egon A
      last name: Ozer
      member of: Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, Illinois, USA.
  slot:
    index: 3
    item: Gambut S
      type: Person
      first name: Stephanie
      last name: Gambut
      member of: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
  slot:
    index: 4
    item: Dean TJ
      type: Person
      first name: Taylor J
      last name: Dean
      member of: Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, Illinois, USA.
  slot:
    index: 5
    item: Zhang L
      type: Person
      first name: Li
      last name: Zhang
      member of: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
  slot:
    index: 6
    item: Bhimalli P
      type: Person
      first name: Pavan
      last name: Bhimalli
      member of: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
  slot:
    index: 7
    item: Schneider JR
      type: Person
      first name: Jeffrey R
      last name: Schneider
      member of: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
  slot:
    index: 8
    item: Mamede JI
      type: Person
      first name: João I
      last name: Mamede
      member of: Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
  slot:
    index: 9
    item: Ison MG
      type: Person
      first name: Michael G
      last name: Ison
      member of: Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Department of Surgery, Division of Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  slot:
    index: 10
    item: Karmali R
      type: Person
      first name: Reem
      last name: Karmali
      member of: Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, USA.
  slot:
    index: 11
    item: Gordon LI
      type: Person
      first name: Leo I
      last name: Gordon
      member of: Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  slot:
    index: 12
    item: Lorenzo-Redondo R
      type: Person
      first name: Ramon
      last name: Lorenzo-Redondo
      member of: Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, Illinois, USA.
  slot:
    index: 13
    item: Hultquist JF
      type: Person
      first name: Judd F
      last name: Hultquist
      member of: Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, Illinois, USA.
created: 2022-7-29T06:00
date last updated: 2025-01-20
issued: 2022-12
dp: 2022 Dec
created: 2022-7-28T07:54
e ISSN: 1399-3062
has issn l: 1398-2273
issue: 6
has NLM journal title abbreviation: Transpl Infect Dis
publication name: Transplant infectious disease : an official journal of the Transplantation Society
language: eng
has national library of medicine journal id: 100883688
derived from: NLM
pg: e13914
has place of publication: Denmark
has primary subject term: D000086402Q000235
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has subject term: D006801
has subject term: D009154
has subject term: D000998
has subject term: D016867
has subject term: D057134
has subject term: D000914
source: Transpl Infect Dis. 2022-12;24(6):e13914.
volume: 24

Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic.
pmid: 36241862
abstract: An increasing number of international studies demonstrate serious negative effects of the COVID-19 pandemic on the timely diagnosis of cancer and on cancer treatment. Our study aimed to quantitatively and qualitatively evaluate the capacities of German Comprehensive Cancer Centers (CCCs) in different areas of complex oncology care during the first 2 years of the COVID-19 pandemic.Prospective panel survey over 23 rounds among 18 CCCs in Germany between March 2020 and June 2022.The COVID-19 pandemic substantially affected the oncological care system in Germany during the first 2 years. Persistent limitations of care in CCCs primarily affected follow-up (- 21%) and psycho-oncologic care (- 12%), but also tumor surgery (- 9%). Substantial limitations were also reported for all other areas of multidisciplinary oncological care.This study documents the limitations of oncological care during the COVID-19 pandemic and highlights the need to develop strategies to avoid similar limitations in the future.
rights: © 2022. The Author(s).
has PII: 10.1007/s00432-022-04407-1
doi: 10.1007/s00432-022-04407-1
creator: OrderedList
  length: 30
  slot:
    index: 1
    item: Arndt V
      type: Person
      first name: Volker
      last name: Arndt
      member of: Division of Clinical Epidemiology and Aging Research (C070), Unit of Cancer Survivorship (C071), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. v.arndt@dkfz-heidelberg.de.
  slot:
    index: 2
    item: Doege D
      type: Person
      first name: Daniela
      last name: Doege
      member of: Division of Clinical Epidemiology and Aging Research (C070), Unit of Cancer Survivorship (C071), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
  slot:
    index: 3
    item: Fröhling S
      type: Person
      first name: Stefan
      last name: Fröhling
      member of: Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  slot:
    index: 4
    item: Albers P
      type: Person
      first name: Peter
      last name: Albers
      member of: Department of Urology, Comprehensive Cancer Center/Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  slot:
    index: 5
    item: Algül H
      type: Person
      first name: Hana
      last name: Algül
      member of: Comprehensive Cancer Center München, Institute for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, Munich, Bavaria, Germany.
  slot:
    index: 6
    item: Bargou R
      type: Person
      first name: Ralf
      last name: Bargou
      member of: Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany.
  slot:
    index: 7
    item: Bokemeyer C
      type: Person
      first name: Carsten
      last name: Bokemeyer
      member of: Medical Clinic and Polyclinic II, Center for Oncology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 8
    item: Bornhäuser M
      type: Person
      first name: Martin
      last name: Bornhäuser
      member of: Medical Clinic I, National Center for Tumor Diseases (NCT/UCC), University Hospital Carl Gustav Carus Dresden, TU Dresden, Dresden, Germany.
  slot:
    index: 9
    item: Brandts CH
      type: Person
      first name: Christian H
      last name: Brandts
      member of: University Cancer Center (UCT) Frankfurt-Marburg, Frankfurt University Hospital, Frankfurt, Germany.
  slot:
    index: 10
    item: Brossart P
      type: Person
      first name: Peter
      last name: Brossart
      member of: Medical Clinic III and Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital Bonn, Bonn, Germany.
  slot:
    index: 11
    item: Brucker SY
      type: Person
      first name: Sara Yvonne
      last name: Brucker
      member of: Comprehensive Cancer Center Tübingen-Stuttgart and Department of Women's Health, University Hospital Tübingen, Tübingen, Germany.
  slot:
    index: 12
    item: Brümmendorf TH
      type: Person
      first name: Tim H
      last name: Brümmendorf
      member of: Medical Clinic IV and Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany.
  slot:
    index: 13
    item: Döhner H
      type: Person
      first name: Hartmut
      last name: Döhner
      member of: Comprehensive Cancer Center Ulm (CCCU) and Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.
  slot:
    index: 14
    item: Gattermann N
      type: Person
      first name: Norbert
      last name: Gattermann
      member of: Department of Hematology, Oncology and Clinical Immunology, Comprehensive Cancer Center/Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  slot:
    index: 15
    item: Hallek M
      type: Person
      first name: Michael
      last name: Hallek
      member of: Clinic I for Internal Medicine and Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital Cologne, Cologne, Germany.
  slot:
    index: 16
    item: Heinemann V
      type: Person
      first name: Volker
      last name: Heinemann
      member of: Medical Clinic and Polyclinic III, LMU Hospital, Munich, Germany.
  slot:
    index: 17
    item: Keilholz U
      type: Person
      first name: Ulrich
      last name: Keilholz
      member of: Charité Comprehensive Cancer Center (CCCC), Berlin, Germany.
  slot:
    index: 18
    item: Kindler T
      type: Person
      first name: Thomas
      last name: Kindler
      member of: University Cancer Center (UCT), University Medical Center Mainz, Mainz, Germany.
  slot:
    index: 19
    item: von Levetzow C
      type: Person
      first name: Cornelia
      last name: von Levetzow
      member of: Clinic I for Internal Medicine and Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital Cologne, Cologne, Germany.
  slot:
    index: 20
    item: Lordick F
      type: Person
      first name: Florian
      last name: Lordick
      member of: University Cancer Center Leipzig and Department of Medicine II, University of Leipzig Medical Center, Leipzig, Germany.
  slot:
    index: 21
    item: Neumann UP
      type: Person
      first name: Ulf Peter
      last name: Neumann
      member of: Department of Visceral and Transplantation Surgery, University Hospital of RWTH Aachen, Aachen, Germany.
  slot:
    index: 22
    item: Peters C
      type: Person
      first name: Christoph
      last name: Peters
      member of: Tumor Center Freiburg, Institute of Molecular Medicine and Cell Research, Freiburg, Germany.
  slot:
    index: 23
    item: Schadendorf D
      type: Person
      first name: Dirk
      last name: Schadendorf
      member of: West German Tumor Center (WTZ) Essen and Clinic for Dermatology, Essen University Hospital, Essen, Germany.
  slot:
    index: 24
    item: Stilgenbauer S
      type: Person
      first name: Stephan
      last name: Stilgenbauer
      member of: Comprehensive Cancer Center Ulm (CCCU) and Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany.
  slot:
    index: 25
    item: Zander T
      type: Person
      first name: Thomas
      last name: Zander
      member of: Clinic I for Internal Medicine and Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital Cologne, Cologne, Germany.
  slot:
    index: 26
    item: Zips D
      type: Person
      first name: Daniel
      last name: Zips
      member of: Comprehensive Cancer Center Tübingen-Stuttgart and Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.
  slot:
    index: 27
    item: Braun D
      type: Person
      first name: Delia
      last name: Braun
      member of: German Cancer Research Center (DKFZ), Heidelberg, Germany.
  slot:
    index: 28
    item: Seufferlein T
      type: Person
      first name: Thomas
      last name: Seufferlein
      member of: German Cancer Society, Berlin, Germany.Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
created: 2022-10-15T06:00
date last updated: 2025-01-20
issued: 2023-02
dp: 2023 Feb
created: 2022-10-14T23:31
e ISSN: 1432-1335
has issn l: 0171-5216
issue: 2
has NLM journal title abbreviation: J Cancer Res Clin Oncol
publication name: Journal of cancer research and clinical oncology
language: eng
has national library of medicine journal id: 7902060
derived from: NLM
starting page: 913
ending page: 919
has place of publication: Germany
has primary subject term: D000086382Q000453
has primary subject term: D009369Q000453Q000628
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000086402
has subject term: D058873
has subject term: D011446
source: J Cancer Res Clin Oncol. 2023-02;149(2):913-919.
volume: 149

Persistent Organic Pollutant Exposure and Thyroid Function among 12-Year-Old Children.
pmid: 36502793
abstract: Polychlorobiphenyls (PCBs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants (POPs) having numerous toxicological properties, including thyroid endocrine disruption. Our aim was to assess the impact of POPs on thyroid hormones among 12-year-old children, while taking puberty into consideration.Exposure to 7 PCBs, 4 OCPs, and 6 PFASs (in µg/L), and free tri-iodothyronine (fT3, pg/mL), free thyroxine (fT4, ng/dL), and thyroid-stimulating hormones (TSH, mIU/L) were assessed through blood-serum measurements at age 12 years in 249 boys and 227 girls of the PELAGIE mother-child cohort (France). Pubertal status was clinically rated using the Tanner stages. For each POP, associations were estimated using linear regression, adjusted for potential confounders.Among boys, hexachlorobenzene and perfluorodecanoic acid were associated with decreased fT3 (log-scale; β [95% confidence interval] = -0.07 [-0.12,-0.02] and β = -0.03 [-0.06,-0.00], respectively). Intermediate levels of perfluorohexanesulfonic acid (PFHxS) and PCB180 were associated, respectively, with increased and decreased fT4. After stratification on pubertal status, PCBs and OCPs were associated with decreased TSH only in the more advanced Tanner stages (3-5) and with decreased fT3 among early Tanner stages (1-2). Among girls, PFHxS was associated with decreased TSH (log-scale; β = -0.15 [-0.29,-0.00]), and perfluorooctanoic acid was associated with decreased fT3 (β2nd_tercile = -0.06 [-0.10,-0.03] and β3rd_tercile = -0.04 [-0.08,-0.00], versus. 1st tercile).This cross-sectional study highlights associations between some POPs and thyroid function disruption, which appears consistent with the literature. Considering that the associations were sex-specific and moderated by pubertal status in boys, complex endocrine interactions are likely involved.
rights: © 2022 The Author(s). Published by S. Karger AG, Basel.
has PII: 000528631
doi: 10.1159/000528631
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Tillaut H
      type: Person
      first name: Hélène
      last name: Tillaut
      member of: Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
  slot:
    index: 2
    item: Monfort C
      type: Person
      first name: Christine
      last name: Monfort
      member of: Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
  slot:
    index: 3
    item: Giton F
      type: Person
      first name: Frank
      last name: Giton
      member of: AP-HP, Pôle Biologie-Pathologie Henri Mondor, Créteil, France.Inserm IMRB, Faculté de Santé, Créteil, France.
  slot:
    index: 4
    item: Warembourg C
      type: Person
      first name: Charline
      last name: Warembourg
      member of: Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
  slot:
    index: 5
    item: Rouget F
      type: Person
      first name: Florence
      last name: Rouget
      member of: Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
  slot:
    index: 6
    item: Cordier S
      type: Person
      first name: Sylvaine
      last name: Cordier
      member of: Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
  slot:
    index: 7
    item: Lainé F
      type: Person
      first name: Fabrice
      last name: Lainé
      member of: CHU Rennes, Inserm CIC1414, Rennes, France.
  slot:
    index: 8
    item: Gaudreau E
      type: Person
      first name: Eric
      last name: Gaudreau
      member of: Centre de Toxicologie du Québec (CTQ), Institut national de santé publique du Québec (INSPQ), Quebec, Québec, Canada.
  slot:
    index: 9
    item: Garlantézec R
      type: Person
      first name: Ronan
      last name: Garlantézec
      member of: Inserm IMRB, Faculté de Santé, Créteil, France.
  slot:
    index: 10
    item: Saint-Amour D
      type: Person
      first name: Dave
      last name: Saint-Amour
      member of: Département de Psychologie, Université du Québec à Montréal, Montréal, Québec, Canada.Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
  slot:
    index: 11
    item: Chevrier C
      type: Person
      first name: Cécile
      last name: Chevrier
      member of: Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France, cecile.chevrier@univ-rennes1.fr.
created: 2022-12-13T06:00
date last updated: 2025-01-19
issued: 2023
dp: 2023
created: 2022-12-12T08:53
e ISSN: 1423-0194
has issn l: 0028-3835
issue: 12
has NLM journal title abbreviation: Neuroendocrinology
publication name: Neuroendocrinology
language: eng
has national library of medicine journal id: 0035665
derived from: NLM
starting page: 1232
ending page: 1247
has place of publication: Switzerland
has primary subject term: D011078
has primary subject term: D004785Q000633
has primary subject term: D006843
has primary subject term: D005466Q000633
has subject term: D008297
has subject term: D005260
has subject term: D006801
has subject term: D002648
has subject term: D013961
has subject term: http://id.nlm.nih.gov/mesh/D000083462
has subject term: D003430
has subject term: D013963
has subject term: D013972
source: Neuroendocrinology. 2023;113(12):1232-1247.
volume: 113

Evaluation of the relationship between abdominal fat distribution and osteoporotic vertebral compression fracture with MRI.
pmid: 36472632
abstract: This study was carried out to investigate the effects of abdominal subcutaneous adiposity and visceral adiposity on osteoporotic compression fractures.The study group consisted of a total of 152 individuals aged 50-80 years; 76 were included in the vertebral fracture group and 76 in the healthy control group, whose bone mineral density was calculated. In order to determine the distribution of abdominal fat in both groups, four different measurements, i.e., sagittal abdominal diameter (SAD), abdominal diameter (AD), ventral subcutaneous thickness (VST), and dorsal subcutaneous thickness (DST), were made using lumbar magnetic resonance imaging (MRI). The visceral fat ratio (VFR) was also calculated based on these measurements.There was a significant difference between the patient and control groups in VST and DST values, both when gender distribution was and was not taken into account (p < 0.006 for all cases). There was no significant difference between the patient and control groups in SAD and AS values, both when only female patients were considered, and gender distribution was not taken into account (p > 0.25 for all cases). On the other hand, in the analysis, when only male patients were considered, the SAD and AD values of the patient group were found to be significantly lower than those of the control group (p = 0.046 and p = 0.048, respectively).In conclusion, the study findings indicated that high SAD values in the male gender and high VST and DST values in both genders were associated with low lumbar vertebral fracture risk.
rights: © 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).
has PII: 10.1007/s00256-022-04247-7
doi: 10.1007/s00256-022-04247-7
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Gürbüz AF
      type: Person
      first name: Ahmet Faruk
      last name: Gürbüz
      member of: Department of Radiology, Ermenek State Hospital, 70400, Karaman, Turkey.
  slot:
    index: 2
    item: Keven A
      type: Person
      first name: Ayşe
      last name: Keven
      member of: Department of Radiology, Akdeniz University School of Medicine, Dumlupınar bulvarıArapsuyu, 07059, Antalya, Turkey. aysekeven@gmail.com.
  slot:
    index: 3
    item: Elasan S
      type: Person
      first name: Sadi
      last name: Elasan
      member of: Department of Biostatistics, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey.
  slot:
    index: 4
    item: Çevikol C
      type: Person
      first name: Can
      last name: Çevikol
      member of: Department of Radiology, Akdeniz University School of Medicine, Dumlupınar bulvarıArapsuyu, 07059, Antalya, Turkey.
created: 2022-12-7T06:00
date last updated: 2025-01-20
issued: 2023-06
dp: 2023 Jun
created: 2022-12-6T11:12
e ISSN: 1432-2161
has issn l: 0364-2348
issue: 6
has NLM journal title abbreviation: Skeletal Radiol
publication name: Skeletal radiology
language: eng
has national library of medicine journal id: 7701953
derived from: NLM
starting page: 1203
ending page: 1210
has place of publication: Germany
has primary subject term: D050815Q000000981
has primary subject term: D016103Q000000981
has primary subject term: D058866Q000000981Q000473
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D050153
has subject term: D008279
has subject term: D015519
source: Skeletal Radiol. 2023-06;52(6):1203-1210.
volume: 52

COVID-19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity.
pmid: 36086941
abstract: Coronavirus disease 2019 (COVID-19) is associated with autoimmune features and autoantibody production in a small subset of the population. Pre-existing neutralizing antitype I interferons (IFNs) autoantibodies are related to the severity of COVID-19. Plasma levels of IgG and IgM against 12 viral antigens and 103 self-antigens were evaluated using an antibody protein array in patients with severe/critical or mild/moderate COVID-19 disease and uninfected controls. Patients exhibited increased IgGs against Severe acute respiratory syndrome coronavirus-2 proteins compared to controls, but no difference was observed in the two patient groups. 78% autoreactive IgGs and 93% autoreactive IgMs were increased in patients versus controls. There was no difference in the plasma levels of anti-type I IFN autoantibodies or neutralizing anti-type I IFN activity of plasma samples from the two patient groups. Increased anti-type I IFN IgGs were correlated with higher lymphocyte accounts, suggesting a role of nonpathogenic autoantibodies. Notably, among the 115 antibodies tested, only plasma levels of IgGs against human coronavirus (HCOV)-229E and HCOV-NL63 spike proteins were associated with mild disease outcome. COVID-19 was associated with a bystander polyclonal autoreactive B cell activation, but none of the autoantibody levels were linked to disease severity. Long-term humoral immunity against HCOV-22E and HCOV-NL63 spike protein was associated with mild disease outcome. Understanding the mechanism of life-threatening COVID-19 is critical to reducing mortality and morbidity.
rights: © 2022 Wiley Periodicals LLC.
doi: 10.1002/jmv.28134
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Jiang W
      type: Person
      first name: Wei
      last name: Jiang
      member of: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.Department of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
  slot:
    index: 2
    item: Johnson D
      type: Person
      first name: Douglas
      last name: Johnson
      member of: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
  slot:
    index: 3
    item: Adekunle R
      type: Person
      first name: Ruth
      last name: Adekunle
      member of: Department of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
  slot:
    index: 4
    item: Heather H
      type: Person
      first name: Hughes
      last name: Heather
      member of: Department of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
  slot:
    index: 5
    item: Xu W
      type: Person
      first name: Wanli
      last name: Xu
      member of: University of Connecticut School of Nursing, Storrs, Connecticut, USA.
  slot:
    index: 6
    item: Cong X
      type: Person
      first name: Xiaomei
      last name: Cong
      member of: University of Connecticut School of Nursing, Storrs, Connecticut, USA.
  slot:
    index: 7
    item: Wu X
      type: Person
      first name: Xueling
      last name: Wu
      member of: Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
  slot:
    index: 8
    item: Fan H
      type: Person
      first name: Hongkuan
      last name: Fan
      member of: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA.
  slot:
    index: 9
    item: Andersson LM
      type: Person
      first name: Lars-Magnus
      last name: Andersson
      member of: Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
  slot:
    index: 10
    item: Robertson J
      type: Person
      first name: Josefina
      last name: Robertson
      member of: Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
  slot:
    index: 11
    item: Gisslén M
      type: Person
      first name: Magnus
      last name: Gisslén
      member of: Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
created: 2022-9-11T06:00
date last updated: 2025-01-20
issued: 2023-01
dp: 2023 01
created: 2022-9-10T05:13
e ISSN: 1096-9071
has issn l: 0146-6615
issue: 1
has NLM journal title abbreviation: J Med Virol
publication name: Journal of medical virology
language: eng
has national library of medicine journal id: 7705876
derived from: NLM
pg: e28134
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has primary subject term: D028941
has primary subject term: D007370
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000086402
has subject term: D001323
has subject term: D062072
has subject term: D064370
has subject term: D000914
source: J Med Virol. 2023-01;95(1):e28134.
volume: 95

Response to bipolar androgen therapy and PD-1 inhibition in a patient with metastatic castration-resistant prostate cancer and a germline CHEK2 mutation.
pmid: 36653039
abstract: We present the case of a patient with germline CHEK2-mutated metastatic castration-resistant prostate cancer (mCRPC) who responded to bipolar androgen therapy (BAT) combined with pembrolizumab after progressing through multiple lines of therapy. The patient was diagnosed in his 40s following an elevated screening prostate-specific antigen and biopsy. Over the course of 20 years, he progressed through nearly all standard therapies including androgen deprivation, combined androgen blockade, traditional chemotherapy, targeted therapies and experimental agents. He was ultimately treated with BAT, whereby the patient's cycle was between low (castrate) and high (supraphysiological) testosterone levels. This counterintuitive approach resulted in a marked response to BAT plus pembrolizumab consolidation lasting 13 months. His underlying germline mutation in CHEK2, an important mediator of DNA repair, may have sensitised the cancer cells to the DNA damage caused by BAT. Single case report outcomes should not be used as evidence of efficacy for treatment regimes. Our case supports further investigation into BAT plus immunotherapy for patients with DNA repair-deficient mCRPC.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/1/e251320
doi: 10.1136/bcr-2022-251320
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Berger BT
      type: Person
      first name: Benjamin T
      last name: Berger
      member of: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA benjamin.t.berger@duke.edu andrew.armstrong@duke.edu.
  slot:
    index: 2
    item: Labriola MK
      type: Person
      first name: Matthew K
      last name: Labriola
      member of: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, North Carolina, USA.
  slot:
    index: 3
    item: Antonarakis ES
      type: Person
      first name: Emmanuel S
      last name: Antonarakis
      member of: Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota Academic Health Center, Minneapolis, Minnesota, USA.
  slot:
    index: 4
    item: Armstrong AJ
      type: Person
      first name: Andrew J
      last name: Armstrong
      member of: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA benjamin.t.berger@duke.edu andrew.armstrong@duke.edu.Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University, Durham, North Carolina, USA.
created: 2023-1-19T06:00
date last updated: 2025-01-20
issued: 2023-01-18
dp: 2023 Jan 18
created: 2023-1-18T20:33
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D064129Q000188Q000235Q000473
has subject term: D008297
has subject term: D006801
has subject term: D000728Q000627
has subject term: D061026
has subject term: D017430
has subject term: D018095
has subject term: D000726Q000627
has subject term: D005854Q000473
has subject term: D064447Q000235
source: BMJ Case Rep. 2023-01-18;16(1):.
volume: 16

Blind loop mucocele of a side-to-end colorectal anastomosis as a rare cause of large bowel obstruction.
pmid: 36657820
abstract: Large bowel obstruction (LBO) after colorectal surgery draws wide differentials. To our knowledge, LBO due to blind colonic limb mucocele of a side-to-end colorectal anastomosis has not yet been described. We report a man in his late 50s presenting with pain, abdominal distension and constipation. He had extensive surgical history; notably, a side-to-end colorectal anastomosis was fashioned following Hartmann-type colostomy reversal. CT and MRI suggested a mucus-filled short blind colonic segment compressing the anastomotic site and causing LBO. Flexible sigmoidoscopy under general anaesthesia showed external rectal compression and lumen narrowing. Transrectal needle aspiration of the blind segment yielded 145 mL of mucoid fluid. The patient's symptoms improved and he was discharged with outpatient Gastrografin enema and flexible sigmoidoscopy which confirmed successful blind segment emptying. This case highlights that blind colonic loop mucoceles in colorectal anastomosis can rarely cause obstruction, and endoscopic management is feasible when accurate diagnosis is confirmed on imaging.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/1/e253103
doi: 10.1136/bcr-2022-253103
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Peacock LPE
      type: Person
      first name: Luke Philip Edward
      last name: Peacock
      member of: St George's, University of London, London, UK luke.peacock@nhs.net.General Surgery, William Harvey Hospital, Ashford, UK.
  slot:
    index: 2
    item: Pangeni A
      type: Person
      first name: Anang
      last name: Pangeni
      member of: General Surgery, William Harvey Hospital, Ashford, UK.
  slot:
    index: 3
    item: Shrestha A
      type: Person
      first name: Ashish
      last name: Shrestha
      member of: General Surgery, William Harvey Hospital, Ashford, UK.
  slot:
    index: 4
    item: Allu VJ
      type: Person
      first name: Veera J
      last name: Allu
      member of: General Surgery, William Harvey Hospital, Ashford, UK.
created: 2023-1-20T06:00
date last updated: 2025-01-20
issued: 2023-01-19
dp: 2023 Jan 19
created: 2023-1-19T20:52
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D009078Q000150Q000000981Q000601
has primary subject term: D007415Q000000981Q000209Q000601
has primary subject term: D015179Q000150
has subject term: D008297
has subject term: D006801
has subject term: D000714Q000379
source: BMJ Case Rep. 2023-01-19;16(1):.
volume: 16

Type A aortic dissection identified by point-of-care ultrasound but missed by CT angiogram.
pmid: 36657822
has PII: 16/1/e253577
doi: 10.1136/bcr-2022-253577
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Buchel B
      type: Person
      first name: Brandon
      last name: Buchel
      member of: Emergency Medicine, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA.
  slot:
    index: 2
    item: Sutarjono B
      type: Person
      first name: Bayu
      last name: Sutarjono
      member of: Emergency Medicine, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA b.sutarjono@saba.edu.
  slot:
    index: 3
    item: Grewal E
      type: Person
      first name: Ekjot
      last name: Grewal
      member of: Emergency Medicine, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA.
created: 2023-1-20T06:00
date last updated: 2025-01-20
issued: 2023-01-19
dp: 2023 01 19
created: 2023-1-19T20:52
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D019095
has primary subject term: D000784Q000000981
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000067716
has subject term: D014463
has subject term: D000792
has subject term: D014057
has subject term: D004636
source: BMJ Case Rep. 2023-01-19;16(1):.
volume: 16

Infliximab substantially re-silenced Wnt/β-catenin signaling and ameliorated doxorubicin-induced cardiomyopathy in rats.
pmid: 36636964
abstract: The release of inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), plays an important role in the pathogenesis of cardiomyopathy. TNF-α increases in plasma and in myocardium of heart failure patients. We aimed to investigate the role of TNF-α inhibitor (infliximab; IFX) in regulating dilated cardiomyopathy (DCM) induced in rats. DCM was induced in rats by doxorubicin (DOX; 3.5 mg. kg-1 , i.p) twice weekly for 3 weeks (21 mg. kg-1 cumulative dose). DCM rats were treated with RPL (1 mg. kg-1 orally, daily), IFX (5 mg. kg-1 ; i.p. once) or their combination for 4 weeks starting next day of last DOX dose. Echocardiography was conducted followed by a collection of blood and left ventricle (LV) for biochemical and histological investigations. DCM rats revealed deteriorated cardiac function (increased CK-MB activity, LVIDs, LVIDd, ESV, and EDV, while decreased EF% and FS%), hypertrophy (increased HW/TL, β-MHC, and α-actin), inflammation (increased IL-1β, IL-6, and TNF-α). The activation of Wnt/β-catenin along with increased gene expression of RAS components (RENIN, ACE, and AT1) were evident. LV architecture also revealed abnormalities and some degree of fibrosis. Treatment with RPL and/or IFX suppressed TNF-α and consequently improved most of these parameters suppressing Wnt/β-catenin/RAS axis. Combined RPL and IFX treatment was the best among all treatments. In conclusion, Wnt/β-catenin/RAS axis is implicated in DOX-induced cardiomyopathy. The upstream TNF-α was proved for the first time in-vivo to stimulate this axis where its inhibition by RPL or IFX prevented DCM. Targeting this axis at two points using RPL and IFX showed better therapeutic efficacy.
rights: © 2023 Wiley Periodicals LLC.
doi: 10.1002/jbt.23312
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Mohamed HE
      type: Person
      first name: Hoda E
      last name: Mohamed
      member of: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  slot:
    index: 2
    item: Askar ME
      type: Person
      first name: Mervat E
      last name: Askar
      member of: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  slot:
    index: 3
    item: Shaheen MA
      type: Person
      first name: Mohamed A
      last name: Shaheen
      member of: Department of Histology and Cell Biology, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
  slot:
    index: 4
    item: Salama AE
      type: Person
      first name: Alaa E
      last name: Salama
      member of: Department of Cardiology, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
  slot:
    index: 5
    item: Idris RA
      type: Person
      first name: Reham A
      last name: Idris
      member of: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  slot:
    index: 6
    item: Younis NN
      type: Person
      first name: Nahla N
      last name: Younis
      member of: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
created: 2023-1-14T06:00
date last updated: 2025-01-20
issued: 2023-05
dp: 2023 May
created: 2023-1-13T05:33
e ISSN: 1099-0461
has issn l: 1095-6670
issue: 5
has NLM journal title abbreviation: J Biochem Mol Toxicol
publication name: Journal of biochemical and molecular toxicology
language: eng
has national library of medicine journal id: 9717231
derived from: NLM
pg: e23312
has place of publication: United States
has primary subject term: D009202Q000139Q000188
has primary subject term: http://id.nlm.nih.gov/mesh/D000069285
has primary subject term: D014409
has subject term: D000818
has subject term: D051381
has subject term: D051176Q000378
has subject term: D004317Q000009
has subject term: D060449Q000187
source: J Biochem Mol Toxicol. 2023-05;37(5):e23312.
volume: 37

Therapeutic potential of curcumin in ARDS and COVID-19.
pmid: 36480131
abstract: Curcumin is a safe, non-toxic, readily available and naturally occurring compound, an active constituent of Curcuma longa (turmeric). Curcumin could potentially treat diseases, but faces poor physicochemical and pharmacological characteristics. To overcome these limitations, we developed a stable, water-soluble formulation of curcumin called cyclodextrin-complexed curcumin (CDC). We have previously shown that direct delivery of CDC to the lung following lipopolysaccharides exposure reduces acute lung injury (ALI) and effectively reduces lung injury, inflammation and mortality in mice following Klebsiella pneumoniae. Recently, we found that administration of CDC led to a significant reduction in angiotensin-converting enzyme 2 and signal transducer and activator of transcription 3 expression in gene and protein levels following pneumonia, indicating its potential in treating coronavirus disease 2019 (COVID-19). In this review, we consider the clinical features of ALI and acute respiratory distress syndrome (ARDS) and the role of curcumin in modulating the pathogenesis of bacterial/viral-induced ARDS and COVID-19.
rights: © 2022 John Wiley & Sons Australia, Ltd.
doi: 10.1111/1440-1681.13744
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Suresh MV
      type: Person
      first name: Madathilparambil V
      last name: Suresh
      member of: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  slot:
    index: 2
    item: Francis S
      type: Person
      first name: Sairah
      last name: Francis
      member of: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  slot:
    index: 3
    item: Aktay S
      type: Person
      first name: Sinan
      last name: Aktay
      member of: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  slot:
    index: 4
    item: Kralovich G
      type: Person
      first name: Georgia
      last name: Kralovich
      member of: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  slot:
    index: 5
    item: Raghavendran K
      type: Person
      first name: Krishnan
      last name: Raghavendran
      member of: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
created: 2022-12-9T06:00
date last updated: 2025-01-20
issued: 2023-04
dp: 2023 04
created: 2022-12-8T14:46
e ISSN: 1440-1681
has issn l: 0305-1870
issue: 4
has NLM journal title abbreviation: Clin Exp Pharmacol Physiol
publication name: Clinical and experimental pharmacology & physiology
language: eng
has national library of medicine journal id: 0425076
derived from: NLM
starting page: 267
ending page: 276
has place of publication: Australia
has primary subject term: D003474Q000494
has primary subject term: D000086382Q000473
has primary subject term: D012128Q000473
has primary subject term: D055371Q000473
has subject term: D051379
has subject term: D000818
has subject term: D008168
source: Clin Exp Pharmacol Physiol. 2023-04;50(4):267-276.
volume: 50

Ruptured ectopic molar pregnancy and ruptured uterine fibroid: a challenging rare diagnosis.
pmid: 36653040
abstract: Although rare and unusual occurrences, a ruptured ectopic molar pregnancy (MP) and a ruptured uterine fibroid can lead to significant maternal morbidity and mortality. We present a unique case of these complications developing concurrently-resulting in the haemodynamic compromise of an otherwise healthy young female patient. The patient underwent a diagnostic laparoscopy which converted into a laparotomy, salpingectomy and myomectomy. Comprehensive histopathology confirmed the diagnosis of a ruptured ectopic complete MP and ruptured uterine fibroid. The patient recovered quickly within days. Prompt definitive management, conclusive histopathology and adequate follow-up were the hallmarks of this singular case. These key factors lead to the rare diagnosis of ruptured ectopic MP and uterine fibroid, prevention of adverse outcomes and provision of comprehensive patient care.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/1/e251045
doi: 10.1136/bcr-2022-251045
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Tanudisastro M
      type: Person
      first name: Marietta
      last name: Tanudisastro
      member of: Obstetrics and Gynaecology, Royal Prince Alfred Hospital Women and Babies Ambulatory Care, Camperdown, New South Wales, Australia marietta.tanudisastro@health.nsw.gov.au.Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
  slot:
    index: 2
    item: Chatterjee R
      type: Person
      first name: Rahul
      last name: Chatterjee
      member of: Obstetrics and Gynaecology, Royal Prince Alfred Hospital Women and Babies Ambulatory Care, Camperdown, New South Wales, Australia.
  slot:
    index: 3
    item: Anderson L
      type: Person
      first name: Lyndal
      last name: Anderson
      member of: Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  slot:
    index: 4
    item: Smirnova S
      type: Person
      first name: Sofia
      last name: Smirnova
      member of: Obstetrics and Gynaecology, Royal Prince Alfred Hospital Women and Babies Ambulatory Care, Camperdown, New South Wales, Australia.
created: 2023-1-19T06:00
date last updated: 2025-01-20
issued: 2023-01-18
dp: 2023 Jan 18
created: 2023-1-18T20:33
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D011271Q000175
has primary subject term: D007889Q000150Q000175Q000601
has primary subject term: D063186
has primary subject term: D006828Q000150Q000175Q000601
has primary subject term: D014594Q000150Q000175Q000601
has subject term: D011247
has subject term: D005260
has subject term: D006801
source: BMJ Case Rep. 2023-01-18;16(1):.
volume: 16

Congenital glaucoma as a presenting feature of Rubinstein-Taybi syndrome in an infant with a novel pathogenic variant in the CREBBP gene.
pmid: 36653044
abstract: Rubinstein-Taybi syndrome, also known as broad thumb-hallux syndrome, is a rare autosomal dominant genetic disorder. This multiorgan syndrome is linked to a pathogenic mutation in the CREBBP or EBP300 genes.We present a patient with a hitherto unreported constellation of anterior segment abnormalities, including congenital glaucoma, congenital corneal keloid, cataract, and distinct facial and systemic features including a high-arched palate, low-set posteriorly rotated ears, Café-au-lait spots on the back, broad terminal phalanges of hands and feet, and bilateral cryptorchidism. The characteristic dysgenetic angle features and ultrasound biomicroscopic findings described in this case report show the occurrence of concomitant congenital keloid with glaucoma.Genetic testing revealed a heterozygous one-base pair duplication in exon 3 of the CREBBP gene (c.886dupC), a novel frameshift pathogenic mutation in the CREBBP gene that has not been previously reported in a clinical setting.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/1/e251543
doi: 10.1136/bcr-2022-251543
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Snehi S
      type: Person
      first name: Sagarika
      last name: Snehi
      member of: Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  slot:
    index: 2
    item: Kaur A
      type: Person
      first name: Anupriya
      last name: Kaur
      member of: Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  slot:
    index: 3
    item: Chaudhry C
      type: Person
      first name: Chakshu
      last name: Chaudhry
      member of: Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  slot:
    index: 4
    item: Kaushik S
      type: Person
      first name: Sushmita
      last name: Kaushik
      member of: Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India sushmita_kaushik@yahoo.com.
created: 2023-1-19T06:00
date last updated: 2025-01-20
issued: 2023-01-18
dp: 2023 Jan 18
created: 2023-1-18T20:33
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D012415Q000150Q000175Q000235
has primary subject term: D007627
has primary subject term: D005901
has primary subject term: D006871
has subject term: D008297
has subject term: D006801
has subject term: D007223
has subject term: D009154
has subject term: D016368
has subject term: D050882Q000235
source: BMJ Case Rep. 2023-01-18;16(1):.
volume: 16

Nephrocolocutaneous fistula from a staghorn calculus.
pmid: 36653049
abstract: Fistula formation between the kidney, colon and the skin is an extremely rare complication arising from renal infections secondary to renal stone formation. During the 1980s, reports of nephrocolic fistulas, with or without involvement of the skin, were commonly caused by genitourinary tuberculosis. Due to improvements in diagnosis and specifically the development of anti-Koch's therapy, the incidence of nephrocolic or nephrocolocutaneous fistulas has become uncommon especially in developed countries.We report a case of a patient residing in a developing country, presenting with a 20-year history of a left flank lesion extruding minimal purulent output daily. He was seen at the emergency department due to weakness and was managed as a case of urosepsis. Contrast-enhanced CT scan and fistulogram showed a staghorn calculus in the left kidney with connections to the descending colon and skin. The patient eventually underwent a left hemicolectomy with en bloc excision of the kidney and fistula tract.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/1/e249351
doi: 10.1136/bcr-2022-249351
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Jacinto CK
      type: Person
      first name: Cesar Karunungan
      last name: Jacinto
      member of: Department of Surgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines rocky_awp@yahoo.com.
  slot:
    index: 2
    item: Lim MGL
      type: Person
      first name: Michael Geoffrey Lee
      last name: Lim
      member of: Department of Surgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
  slot:
    index: 3
    item: Lopez MPJ
      type: Person
      first name: Marc Paul Jose
      last name: Lopez
      member of: Department of Surgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
  slot:
    index: 4
    item: Serrano DP
      type: Person
      first name: Dennis Pestano
      last name: Serrano
      member of: Department of Surgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
created: 2023-1-19T06:00
date last updated: 2025-01-20
issued: 2023-01-18
dp: 2023 Jan 18
created: 2023-1-18T20:33
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D000069856Q000150
has primary subject term: D014548Q000000981Q000209Q000601
has primary subject term: D007669Q000150Q000000981Q000601
has subject term: D008297
has subject term: D006801
has subject term: D011859
has subject term: D014057Q000009
source: BMJ Case Rep. 2023-01-18;16(1):.
volume: 16

Skin Barrier Function and Cognition among Older Adults.
pmid: 36641132
has PII: S0022-202X(22)02897-4
doi: 10.1016/j.jid.2022.11.023
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Kim RW
      type: Person
      first name: Richard W
      last name: Kim
      member of: University of California San Francisco School of Medicine, San Francisco, California, USA.
  slot:
    index: 2
    item: An Y
      type: Person
      first name: Yang
      last name: An
      member of: Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.
  slot:
    index: 3
    item: Zukley L
      type: Person
      first name: Linda
      last name: Zukley
      member of: Clinical Research Unit, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.
  slot:
    index: 4
    item: Ferrucci L
      type: Person
      first name: Luigi
      last name: Ferrucci
      member of: Clinical Research Unit, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.
  slot:
    index: 5
    item: Mauro T
      type: Person
      first name: Theodora
      last name: Mauro
      member of: Department of Dermatology, University of California San Francisco, San Francisco, California, USA; Dermatology Service, Veterans Affairs Health Care System, San Francisco, California, USA.
  slot:
    index: 6
    item: Yaffe K
      type: Person
      first name: Kristine
      last name: Yaffe
      member of: Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA; Department of Neurology, University of California San Francisco, San Francisco, California, USA; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California, USA.
  slot:
    index: 7
    item: Resnick SM
      type: Person
      first name: Susan M
      last name: Resnick
      member of: Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.
  slot:
    index: 8
    item: Abuabara K
      type: Person
      first name: Katrina
      last name: Abuabara
      member of: Department of Dermatology, University of California San Francisco, San Francisco, California, USA. Electronic address: Katrina.abuabara@ucsf.edu.
created: 2023-1-15T06:00
date last updated: 2025-01-20
issued: 2023-06
dp: 2023 06
created: 2023-1-14T19:29
e ISSN: 1523-1747
has issn l: 0022-202X
issue: 6
has NLM journal title abbreviation: J Invest Dermatol
publication name: The Journal of investigative dermatology
language: eng
has national library of medicine journal id: 0426720
derived from: NLM
starting page: 1085
ending page: 1087
has place of publication: United States
has primary subject term: D003071
has primary subject term: D012879
has subject term: D006801
has subject term: D000368
source: J Invest Dermatol. 2023-06;143(6):1085-1087.
volume: 143

Neonatal herpes simplex presenting as a zosteriform eruption.
pmid: 36657819
abstract: Herpes simplex virus (HSV) infection in newborn infants is a potentially devastating disease leading to death and disability. Skin, eye and mouth (SEM) infections account for approximately half of the cases in the USA. The appearance of skin findings often guides clinicians towards early diagnosis of HSV infection, prompt interventions and life-saving management; however, less than half of neonates with proven disease present with characteristic vesicular lesions. Furthermore, if SEM infections are not treated promptly, there is significant risk of progression to central nervous system and disseminated disease. We present a case of HSV-2 infection in a neonate with an atypical zosteriform eruption on day 3 of life. This case demonstrates that neonatal HSV can unusually present in a zosteriform rash. By elucidating this unique presentation, we highlight atypical HSV skin presentation and emphasise on the importance of earlier diagnosis and antiviral treatment to prevent the associated morbidity and mortality.
rights: © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: 16/1/e252627
doi: 10.1136/bcr-2022-252627
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Anderson E
      type: Person
      first name: Elizabeth
      last name: Anderson
      member of: Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
  slot:
    index: 2
    item: Johns E
      type: Person
      first name: Emma
      last name: Johns
      member of: Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
  slot:
    index: 3
    item: Conlon J
      type: Person
      first name: Joseph
      last name: Conlon
      member of: Department of Pediatrics and Department of Dermatology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.Department of Pediatrics, Springfield Clinic, Springfield, Illinois, USA.
  slot:
    index: 4
    item: Saleh E
      type: Person
      first name: Ezzeldin
      last name: Saleh
      member of: Pediatrics-Infectious Diseases, Southern Illinois University School of Medicine, Springfield, Illinois, USA esaleh84@siumed.edu.
created: 2023-1-20T06:00
date last updated: 2025-01-20
issued: 2023-01-19
dp: 2023 Jan 19
created: 2023-1-19T20:52
e ISSN: 1757-790X
has issn l: 1757-790X
issue: 1
has NLM journal title abbreviation: BMJ Case Rep
publication name: BMJ case reports
language: eng
has national library of medicine journal id: 101526291
derived from: NLM
has place of publication: England
has primary subject term: D006561Q000175Q000188
has primary subject term: D011251Q000175
has primary subject term: D005076Q000188
has primary subject term: D007232Q000188
has subject term: D007231
has subject term: D007223
has subject term: D011247
has subject term: D005260
has subject term: D006801
has subject term: D000998Q000627
source: BMJ Case Rep. 2023-01-19;16(1):.
volume: 16

Overlapping but separate number representations in the intraparietal sulcus-Probing format- and modality-independence in sighted Braille readers.
pmid: 37003099
abstract: The Triple-Code Model stipulates that numerical information from different formats and modalities converges on a common magnitude representation in the Intraparietal Sulcus (IPS). To what extent the representations of all numerosity forms overlap remains unsolved. It has been postulated that the representation of symbolic numerosities (for example, Arabic digits) is sparser and grounded in an existing representation that codes for non-symbolic numerosity information (i.e., sets of objects). Other theories argue that numerical symbols represent a separate number category that emerges only during education. Here, we tested a unique group of sighted tactile Braille readers with numerosities 2, 4, 6 and 8 in three number notations: Arabic digits, sets of dots, tactile Braille numbers. Using univariate methods, we showed a consistent overlap in activations evoked by these three number notations. This result shows that all three used notations are represented in the IPS, which may suggest at least a partial overlap between the representations of the three notations used in this experiment. Using MVPA, we found that only non-automatized number information (Braille and sets of dots) allowed successful number classification. However, the numerosity of one notation could not be predicted above chance from the brain activation patterns evoked by another notation (no cross-classification). These results show that the IPS may host independent number codes in overlapping cortical circuits. In addition, they suggest that the level of training in encoding a given type of number information is an important factor that determines the amount of exploitable information and needs to be controlled for in order to identify the neural code underlying numerical information per se.
rights: Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
has PII: S0010-9452(23)00043-6
doi: 10.1016/j.cortex.2023.01.011
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Czarnecka M
      type: Person
      first name: Maria
      last name: Czarnecka
      member of: Institute of Psychology, Jagiellonian University, Krakow, Poland. Electronic address: mhczarnecka@gmail.com.
  slot:
    index: 2
    item: Rączy K
      type: Person
      first name: Katarzyna
      last name: Rączy
      member of: Institute of Psychology, Jagiellonian University, Krakow, Poland; Biological Psychology and Neuropsychology, University of Hamburg, Hamburg, Germany.
  slot:
    index: 3
    item: Szewczyk J
      type: Person
      first name: Jakub
      last name: Szewczyk
      member of: Institute of Psychology, Jagiellonian University, Krakow, Poland; Department of Psychology, University of Illinois, Urbana Champaign.
  slot:
    index: 4
    item: Paplińska M
      type: Person
      first name: Małgorzata
      last name: Paplińska
      member of: The Maria Grzegorzewska University, Warsaw, Poland.
  slot:
    index: 5
    item: Jednoróg K
      type: Person
      first name: Katarzyna
      last name: Jednoróg
      member of: Laboratory of Language Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
  slot:
    index: 6
    item: Marchewka A
      type: Person
      first name: Artur
      last name: Marchewka
      member of: Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
  slot:
    index: 7
    item: Hesselmann G
      type: Person
      first name: Guido
      last name: Hesselmann
      member of: Department of General and Biological Psychology, Psychologische Hochschule Berlin, Berlin, Germany.
  slot:
    index: 8
    item: Knops A
      type: Person
      first name: André
      last name: Knops
      member of: UMR CNRS 8240, Laboratory for the Psychology of Child Development and Education, University of Paris, Paris, France.
  slot:
    index: 9
    item: Szwed M
      type: Person
      first name: Marcin
      last name: Szwed
      member of: Institute of Psychology, Jagiellonian University, Krakow, Poland. Electronic address: m.szwed@uj.edu.pl.
created: 2023-4-2T06:00
date last updated: 2025-01-19
issued: 2023-05
dp: 2023 05
created: 2023-4-1T18:05
e ISSN: 1973-8102
has issn l: 0010-9452
has NLM journal title abbreviation: Cortex
publication name: Cortex; a journal devoted to the study of the nervous system and behavior
language: eng
has national library of medicine journal id: 0100725
derived from: NLM
starting page: 65
ending page: 80
has place of publication: Italy
has primary subject term: D008279Q000379
has primary subject term: D007802
has subject term: D006801
has subject term: D010296Q000502
has subject term: D014110
has subject term: D001931
source: Cortex. 2023-05;162():65-80.
volume: 162

Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation.
pmid: 36908295
abstract: Acute ischemic stroke (AIS) is a leading cause of mortality that occurs when an embolus becomes lodged in the cerebral vasculature and obstructs blood flow in the brain. The severity of AIS is determined by the location and how extensively emboli become lodged, which are dictated in large part by the cerebral flow and the dynamics of embolus migration which are difficult to measure in vivo in AIS patients. Computational fluid dynamics (CFD) can be used to predict the patient-specific hemodynamics and embolus migration and lodging in the cerebral vasculature to better understand the underlying mechanics of AIS. To be relied upon, however, the computational simulations must be verified and validated. In this study, a realistic in vitro experimental model and a corresponding computational model of the cerebral vasculature are established that can be used to investigate flow and embolus migration and lodging in the brain. First, the in vitro anatomical model is described, including how the flow distribution in the model is tuned to match physiological measurements from the literature. Measurements of pressure and flow rate for both normal and stroke conditions were acquired and corresponding CFD simulations were performed and compared with the experiments to validate the flow predictions. Overall, the CFD simulations were in relatively close agreement with the experiments, to within ±7% of the mean experimental data with many of the CFD predictions within the uncertainty of the experimental measurement. This work provides an in vitro benchmark data set for flow in a realistic cerebrovascular model and is a first step towards validating a computational model of AIS.
rights: © 2023 Bhardwaj, Craven, Sever, Costanzo, Simon and Manning.
doi: 10.3389/fmedt.2023.1130201
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Bhardwaj S
      type: Person
      first name: Saurabh
      last name: Bhardwaj
      member of: Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States.
  slot:
    index: 2
    item: Craven BA
      type: Person
      first name: Brent A
      last name: Craven
      member of: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, United States.
  slot:
    index: 3
    item: Sever JE
      type: Person
      first name: Jacob E
      last name: Sever
      member of: Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States.
  slot:
    index: 4
    item: Costanzo F
      type: Person
      first name: Francesco
      last name: Costanzo
      member of: Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States.Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA, United States.
  slot:
    index: 5
    item: Simon SD
      type: Person
      first name: Scott D
      last name: Simon
      member of: Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA, United States.
  slot:
    index: 6
    item: Manning KB
      type: Person
      first name: Keefe B
      last name: Manning
      member of: Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, United States.Department of Surgery, Penn State Hershey Medical Center, Hershey, PA, United States.
created: 2023-3-14T06:00
date last updated: 2025-01-20
issued: 2023
dp: 2023
created: 2023-3-13T03:45
e ISSN: 2673-3129
has issn l: 2673-3129
has NLM journal title abbreviation: Front Med Technol
publication name: Frontiers in medical technology
language: eng
has national library of medicine journal id: 101772626
derived from: NLM
pg: 1130201
has place of publication: Switzerland
source: Front Med Technol. 2023;5():1130201.
volume: 5

http://rdf.ncbi.nlm.nih.gov/pubmed/36908838
pmid: 36908838
abstract: This systematic review is part of a broader evidence synthesis which aims to produce two systematic reviews to address a significant gap in the evidence base identified by Luchenski et al. (2018) and by (White, 2018). The first review (which is the subject of this protocol) will use meta-analysis to examine the effectiveness of different psychosocial interventions in (1) reducing problematic substance use; (2) improving mental health; and (3) improving housing stability for adults experiencing homelessness. The second review (which is covered by a separate title registration and protocol) will be of the experiences of adults experiencing homelessness when accessing or using psychosocial interventions, and will be a qualitative evidence synthesis using thematic synthesis (Thomas & Harden, 2008).
rights: © 2022 The Authors. Campbell Systematic Reviews published by John Wiley & Sons Ltd on behalf of The Campbell Collaboration.
has PII: CL21290
doi: 10.1002/cl2.1290
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: O'Leary C
      type: Person
      first name: Chris
      last name: O'Leary
      member of: Policy Evaluation and Research Unit Manchester Metropolitan University Manchester UK.
  slot:
    index: 2
    item: Teixeira L
      type: Person
      first name: Ligia
      last name: Teixeira
      member of: Centre for Homelessness Impact London UK.
  slot:
    index: 3
    item: Coren E
      type: Person
      first name: Esther
      last name: Coren
      member of: Canterbury Christchurch University Canterbury UK.
  slot:
    index: 4
    item: Kiss Z
      type: Person
      first name: Zsolt
      last name: Kiss
      member of: ZK Analytics Oxford UK.
  slot:
    index: 5
    item: Roberts A
      type: Person
      first name: Anton
      last name: Roberts
      member of: Policy Evaluation and Research Unit Manchester Metropolitan University Manchester UK.
  slot:
    index: 6
    item: Amitage H
      type: Person
      first name: Harry
      last name: Amitage
      member of: Policy Evaluation and Research Unit Manchester Metropolitan University Manchester UK.
created: 2023-3-14T06:00
date last updated: 2025-01-20
issued: 2022-12
dp: 2022 Dec
created: 2023-3-13T03:52
e ISSN: 1891-1803
has issn l: 1891-1803
issue: 4
has NLM journal title abbreviation: Campbell Syst Rev
publication name: Campbell systematic reviews
language: eng
has national library of medicine journal id: 9918227275506676
derived from: NLM
pg: e1290
has place of publication: United States
source: Campbell Syst Rev. 2022-12;18(4):e1290.
title: PROTOCOL: The effectiveness of psychosocial interventions for reducing problematic substance use, improving mental health, and improving housing stability for adults experiencing homelessness: A systematic review and meta-analysis.
volume: 18

Build-up and dephasing of Floquet-Bloch bands on subcycle timescales.
pmid: 37046087
abstract: Strong light fields have created opportunities to tailor novel functionalities of solids1-5. Floquet-Bloch states can form under periodic driving of electrons and enable exotic quantum phases6-15. On subcycle timescales, lightwaves can simultaneously drive intraband currents16-29 and interband transitions18,19,30,31, which enable high-harmonic generation16,18,19,21,22,25,28-30 and pave the way towards ultrafast electronics. Yet, the interplay of intraband and interband excitations and their relation to Floquet physics have been key open questions as dynamical aspects of Floquet states have remained elusive. Here we provide this link by visualizing the ultrafast build-up of Floquet-Bloch bands with time-resolved and angle-resolved photoemission spectroscopy. We drive surface states on a topological insulator32,33 with mid-infrared fields-strong enough for high-harmonic generation-and directly monitor the transient band structure with subcycle time resolution. Starting with strong intraband currents, we observe how Floquet sidebands emerge within a single optical cycle; intraband acceleration simultaneously proceeds in multiple sidebands until high-energy electrons scatter into bulk states and dissipation destroys the Floquet bands. Quantum non-equilibrium calculations explain the simultaneous occurrence of Floquet states with intraband and interband dynamics. Our joint experiment and theory study provides a direct time-domain view of Floquet physics and explores the fundamental frontiers of ultrafast band-structure engineering.
rights: © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
has PII: 10.1038/s41586-023-05850-x
doi: 10.1038/s41586-023-05850-x
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Ito S
      type: Person
      first name: S
      last name: Ito
      member of: Department of Physics, Philipps-University of Marburg, Marburg, Germany.
  slot:
    index: 2
    item: Schüler M
      type: Person
      first name: M
      last name: Schüler
      member of: Laboratory for Materials Simulations, Paul Scherrer Institute, Villigen PSI, Switzerland.Department of Physics, University of Fribourg, Fribourg, Switzerland.
  slot:
    index: 3
    item: Meierhofer M
      type: Person
      first name: M
      last name: Meierhofer
      member of: Department of Physics, University of Regensburg, Regensburg, Germany.
  slot:
    index: 4
    item: Schlauderer S
      type: Person
      first name: S
      last name: Schlauderer
      member of: Department of Physics, University of Regensburg, Regensburg, Germany.
  slot:
    index: 5
    item: Freudenstein J
      type: Person
      first name: J
      last name: Freudenstein
      member of: Department of Physics, University of Regensburg, Regensburg, Germany.
  slot:
    index: 6
    item: Reimann J
      type: Person
      first name: J
      last name: Reimann
      member of: Department of Physics, Philipps-University of Marburg, Marburg, Germany.
  slot:
    index: 7
    item: Afanasiev D
      type: Person
      first name: D
      last name: Afanasiev
      member of: Department of Physics, University of Regensburg, Regensburg, Germany.
  slot:
    index: 8
    item: Kokh KA
      type: Person
      first name: K A
      last name: Kokh
      member of: A.V. Rzhanov Institute of Semiconductor Physics and V.S. Sobolev Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russian Federation.
  slot:
    index: 9
    item: Tereshchenko OE
      type: Person
      first name: O E
      last name: Tereshchenko
      member of: A.V. Rzhanov Institute of Semiconductor Physics and V.S. Sobolev Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russian Federation.
  slot:
    index: 10
    item: Güdde J
      type: Person
      first name: J
      last name: Güdde
      member of: Department of Physics, Philipps-University of Marburg, Marburg, Germany.
  slot:
    index: 11
    item: Sentef MA
      type: Person
      first name: M A
      last name: Sentef
      member of: Max Planck Institute for the Structure and Dynamics of Matter, Hamburg, Germany. michael.sentef@mpsd.mpg.de.
  slot:
    index: 12
    item: Höfer U
      type: Person
      first name: U
      last name: Höfer
      member of: Department of Physics, Philipps-University of Marburg, Marburg, Germany. hoefer@physik.uni-marburg.de.Department of Physics, University of Regensburg, Regensburg, Germany. hoefer@physik.uni-marburg.de.
  slot:
    index: 13
    item: Huber R
      type: Person
      first name: R
      last name: Huber
      member of: Department of Physics, University of Regensburg, Regensburg, Germany. rupert.huber@physik.uni-regensburg.de.
created: 2023-4-13T06:00
date last updated: 2025-01-20
issued: 2023-04
dp: 2023 04
created: 2023-4-12T23:29
e ISSN: 1476-4687
has issn l: 0028-0836
issue: 7958
has NLM journal title abbreviation: Nature
publication name: Nature
language: eng
has national library of medicine journal id: 0410462
derived from: NLM
starting page: 696
ending page: 701
has place of publication: England
source: Nature. 2023-04;616(7958):696-701.
volume: 616

Influence of hepatic dysfunction in patients who underwent tricuspid valve surgery.
pmid: 37197498
abstract: Hepatic dysfunction (HD) is frequently associated with chronic tricuspid regurgitation (TR), and is a risk factor for TR surgery. Late referral of patients with TR is associated with the progression of TR and HD, as well as an increase in surgical morbidity and mortality. Many patients with severe TR suffer from HD; however, their clinical impact is not well documented.This retrospective review was conducted between October 2008 and July 2017. In total, 159 consecutive patients underwent surgery for TR; 101 with moderate to severe TR were included. We divided patients into N (normal liver function; n=56) and HD (HD; n=45) groups. HD was defined as clinically or radiologically diagnosed liver cirrhosis, or a preoperative Model for End-Stage Liver Disease (MELD)-XI score ≥13. Perioperative data were compared between groups, and changes in the MELD score following TR surgery were estimated in the HD group. Long-term survival rates were analyzed, and analyses were performed to obtain the assessment tool and cutoff value to determine the degree of HD affecting late mortality.The preoperative demographics of both groups were similar, excluding the presence of HD. The EuroSCORE II, MELD score, and prothrombin time international normalization ratio were significantly higher in the HD group, and although early mortality was comparable between groups [N group: 0%, HD group: 2.2% (n=1); P=0.446], intensive care unit and hospital stays were significantly longer in the HD group. The MELD score in the HD group temporarily increased immediately after surgery, and then decreased. The long-term survival rates were significantly lower in the HD group. The most suitable tool for predicting late mortality was the MELD-XI score, with a cutoff value of 13 points.Surgery for patients with severe TR can be performed with relatively low morbidity and operative mortality, regardless of associated HD. MELD scores significantly improved after TR surgery in patients with HD. Even with favorable[cell cut: 2160 characters, first 2000 kept]
rights: 2023 Journal of Thoracic Disease. All rights reserved.
has PII: jtd-15-04-1614
doi: 10.21037/jtd-22-1741
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lim MH
      type: Person
      first name: Mi Hee
      last name: Lim
      member of: Cardiovascular Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan-si, Korea.
  slot:
    index: 2
    item: Lee CH
      type: Person
      first name: Chee-Hoon
      last name: Lee
      member of: Cardiovascular Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan-si, Korea.
  slot:
    index: 3
    item: Ju MH
      type: Person
      first name: Min Ho
      last name: Ju
      member of: Cardiovascular Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan-si, Korea.
  slot:
    index: 4
    item: Je HG
      type: Person
      first name: Hyung Gon
      last name: Je
      member of: Cardiovascular Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan-si, Korea.
created: 2023-5-18T01:07
date last updated: 2025-01-20
issued: 2023-04-28
dp: 2023 Apr 28
created: 2023-5-17T20:02
ISSN: 2072-1439
has issn l: 2072-1439
issue: 4
has NLM journal title abbreviation: J Thorac Dis
publication name: Journal of thoracic disease
language: eng
has national library of medicine journal id: 101533916
derived from: NLM
starting page: 1614
ending page: 1626
has place of publication: China
source: J Thorac Dis. 2023-04-28;15(4):1614-1626.
volume: 15

Exosome-loaded microneedle patches: Promising factor delivery route.
pmid: 37302628
abstract: During the past decades, the advent of different microneedle patch (MNPs) systems paves the way for the targeted and efficient delivery of several growth factors into the injured sites. MNPs consist of several micro-sized (25-1500 μm) needle rows for painless delivery of incorporated therapeutics and increase of regenerative outcomes. Recent data have indicated the multifunctional potential of varied MNP types for clinical applications. Advances in the application of materials and fabrication processes enable researchers and clinicians to apply several MNP types for different purposes such as inflammatory conditions, ischemic disease, metabolic disorders, vaccination, etc. Exosomes (Exos) are one of the most interesting biological bioshuttles that participate in cell-to-cell paracrine interaction with the transfer of signaling biomolecules. These nano-sized particles, ranging from 50 to 150 nm, can exploit several mechanisms to enter the target cells and deliver their cargo into the cytosol. In recent years, both intact and engineered Exos have been increasingly used to accelerate the healing process and restore the function of injured organs. Considering the numerous benefits provided by MNPs, it is logical to hypothesize that the development of MNPs loaded with Exos provides an efficient therapeutic platform for the alleviation of several pathologies. In this review article, the authors collected recent advances in the application of MNP-loaded Exos for therapeutic purposes.
rights: Copyright © 2023 Elsevier B.V. All rights reserved.
has PII: S0141-8130(23)02126-8
doi: 10.1016/j.ijbiomac.2023.125232
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Fathi-Karkan S
      type: Person
      first name: Sonia
      last name: Fathi-Karkan
      member of: Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
  slot:
    index: 2
    item: Heidarzadeh M
      type: Person
      first name: Morteza
      last name: Heidarzadeh
      member of: Koç University Research Centre for Translational Medicine (KUTTAM), Koç University School of Medicine, Istanbul, Turkey.
  slot:
    index: 3
    item: Narmi MT
      type: Person
      first name: Maryam Taghavi
      last name: Narmi
      member of: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 4
    item: Mardi N
      type: Person
      first name: Narges
      last name: Mardi
      member of: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 5
    item: Amini H
      type: Person
      first name: Hassan
      last name: Amini
      member of: Department of General and Vascular Surgery, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 6
    item: Saghati S
      type: Person
      first name: Sepideh
      last name: Saghati
      member of: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 7
    item: Abrbekoh FN
      type: Person
      first name: Fateme Nazary
      last name: Abrbekoh
      member of: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 8
    item: Saghebasl S
      type: Person
      first name: Solmaz
      last name: Saghebasl
      member of: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  slot:
    index: 9
    item: Rahbarghazi R
      type: Person
      first name: Reza
      last name: Rahbarghazi
      member of: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: rahbarghazir@tbzmed.ac.ir.
  slot:
    index: 10
    item: Khoshfetrat AB
      type: Person
      first name: Ali Baradari
      last name: Khoshfetrat
      member of: Chemical Engineering Faculty, Sahand University of Technology, Tabriz 51335-1996, Iran. Electronic address: khoshfetrat@sut.ac.ir.
created: 2023-6-12T00:42
date last updated: 2025-01-19
issued: 2023-07-15
dp: 2023 Jul 15
created: 2023-6-11T19:16
e ISSN: 1879-0003
has issn l: 0141-8130
has NLM journal title abbreviation: Int J Biol Macromol
publication name: International journal of biological macromolecules
language: eng
has national library of medicine journal id: 7909578
derived from: NLM
pg: 125232
has place of publication: Netherlands
has primary subject term: D055354Q000378
has subject term: D014945
has subject term: D016503
has subject term: D009339
has subject term: D014611
source: Int J Biol Macromol. 2023-07-15;243():125232.
volume: 243

Letter from the Editor: Antibody screening in patients with inflammatory myopathies.
pmid: 37379902
has PII: S0190-9622(23)01190-8
doi: 10.1016/j.jaad.2023.06.029
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Elston DM
      type: Person
      first name: Dirk M
      last name: Elston
      member of: Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address: elstond@musc.edu.
created: 2023-6-29T01:08
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2023-6-28T19:12
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
starting page: 233
ending page: 234
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):233-234.
volume: 92

Deconstructing Fat to Reverse Radiation Induced Soft Tissue Fibrosis.
pmid: 37370673
abstract: Adipose tissue is composed of a collection of cells with valuable structural and regenerative function. Taken as an autologous graft, these cells can be used to address soft tissue defects and irregularities, while also providing a reparative effect on the surrounding tissues. Adipose-derived stem or stromal cells are primarily responsible for this regenerative effect through direct differentiation into native cells and via secretion of numerous growth factors and cytokines that stimulate angiogenesis and disrupt pro-inflammatory pathways. Separating adipose tissue into its component parts, i.e., cells, scaffolds and proteins, has provided new regenerative therapies for skin and soft tissue pathology, including that resulting from radiation. Recent studies in both animal models and clinical trials have demonstrated the ability of autologous fat grafting to reverse radiation induced skin fibrosis. An improved understanding of the complex pathologic mechanism of RIF has allowed researchers to harness the specific function of the ASCs to engineer enriched fat graft constructs to improve the therapeutic effect of AFG.
has PII: bioengineering10060742
doi: 10.3390/bioengineering10060742
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Prescher H
      type: Person
      first name: Hannes
      last name: Prescher
      member of: Section of Plastic & Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL 60615, USA.
  slot:
    index: 2
    item: Froimson JR
      type: Person
      first name: Jill R
      last name: Froimson
      member of: Section of Plastic & Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL 60615, USA.
  slot:
    index: 3
    item: Hanson SE
      type: Person
      first name: Summer E
      last name: Hanson
      member of: Section of Plastic & Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL 60615, USA.
created: 2023-6-28T06:42
date last updated: 2025-01-20
issued: 2023-06-20
dp: 2023 Jun 20
created: 2023-6-28T01:02
ISSN: 2306-5354
has issn l: 2306-5354
issue: 6
has NLM journal title abbreviation: Bioengineering (Basel)
publication name: Bioengineering (Basel, Switzerland)
language: eng
has national library of medicine journal id: 101676056
derived from: NLM
has place of publication: Switzerland
source: Bioengineering (Basel). 2023-06-20;10(6):.
volume: 10

3D versus 2D laparoscopic distal gastrectomy in patients with gastric cancer: a systematic review and meta-analysis.
pmid: 37430123
abstract: While laparoscopic gastrectomy is a prominent therapeutic approach for distal gastric cancer, the clinical benefits of 3D laparoscopy over 2D laparoscopy remain unclear. We aimed to compare the clinical outcomes of 3D laparoscopy and 2D laparoscopy for distal gastric cancer resection through a systematic review and meta-analysis.We searched PubMed/MEDLINE, EMBASE, and Cochrane Library databases for studies published from inception through January 2023, according to the PRISMA guidelines. The MD or RR was used to compare 3D and 2D distal gastrectomy. Random-effects meta-analysis was estimated using the inverse variance and Mantel-Haenszel method for binary outcomes and the DerSimonian-Laird estimator for continuous outcomes.After reviewing 559 studies, 6 manuscripts met the inclusion criteria. The analysis included 689 patients, with 348 (50.5%) in the 3D group and 341 (49.5%) in the 2D group. 3D laparoscopic gastrectomy reduces the operative time (WMD - 28.57 min, 95% CI - 50.70 to - 6.44, p = 0.011), intraoperative blood loss (WMD - 6.69 mL, 95% CI - 8.09 to - 5.29, p < 0.001), and postoperative hospital stay (WMD - 0.92 days, 95% CI - 1.43 to - 0.42, p < 0.001). There were no significant differences in time to first postoperative flatus (WMD - 0.22 days, 95% CI - 0.50 to 0.05, p = 0.110), postoperative complications (Relative Risk 0.56, 95% CI 0.22 to 1.41, p = 0.217), and the number of retrieved lymph nodes (WMD 1.25, 95% CI - 0.54 to 3.03, p = 0.172) between 3 and 2D laparoscopic distal gastrectomy.Our study highlights the potential advantages of 3D laparoscopy in distal gastrectomy, including shorter operative time, postoperative hospital stay, and decreased intraoperative blood loss.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s00464-023-10271-y
doi: 10.1007/s00464-023-10271-y
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Rodrigues ACLF
      type: Person
      first name: Amanda Cyntia Lima Fonseca
      last name: Rodrigues
      member of: Department of Medicine, Positivo University, Curitiba, Brazil.Department of Statistics and Biostatistics, Anhembi Morumbi University, Curitiba, Brazil.
  slot:
    index: 2
    item: Shojaeian F
      type: Person
      first name: Fatemeh
      last name: Shojaeian
      member of: Department of Surgery, The Johns Hopkins University, 600 N. Wolfe St, Blalock 618, Baltimore, MD, 21093, USA.
  slot:
    index: 3
    item: Thanawiboonchai T
      type: Person
      first name: Theethawat
      last name: Thanawiboonchai
      member of: Department of Surgery, The Johns Hopkins University, 600 N. Wolfe St, Blalock 618, Baltimore, MD, 21093, USA.
  slot:
    index: 4
    item: Zevallos A
      type: Person
      first name: Alba
      last name: Zevallos
      member of: Department of Surgery, Northwest Hospital, Randallstown, MD, USA.Universidad Científica del Sur, Lima, Peru.
  slot:
    index: 5
    item: Greer J
      type: Person
      first name: Jonathan
      last name: Greer
      member of: Department of Surgery, The Johns Hopkins University, 600 N. Wolfe St, Blalock 618, Baltimore, MD, 21093, USA.
  slot:
    index: 6
    item: Adrales GL
      type: Person
      first name: Gina L
      last name: Adrales
      member of: Department of Surgery, The Johns Hopkins University, 600 N. Wolfe St, Blalock 618, Baltimore, MD, 21093, USA. gadrale1@jhmi.edu.
created: 2023-7-11T01:08
date last updated: 2025-01-20
issued: 2023-10
dp: 2023 10
created: 2023-7-10T23:31
e ISSN: 1432-2218
has issn l: 0930-2794
issue: 10
has NLM journal title abbreviation: Surg Endosc
publication name: Surgical endoscopy
language: eng
has national library of medicine journal id: 8806653
derived from: NLM
starting page: 7914
ending page: 7922
has place of publication: Germany
has primary subject term: D013274Q000601Q000150
has primary subject term: D010535Q000379
has subject term: D006801
has subject term: D016063
has subject term: D016896
has subject term: D011183Q000453Q000209Q000601
has subject term: D005743Q000379
source: Surg Endosc. 2023-10;37(10):7914-7922.
volume: 37

Does addition of aromatherapy and music help to reduce pain and anxiety during shockwave lithotripsy compared to standard analgesia alone? A randomised controlled trial.
pmid: 37395910
abstract: To assess the effect of aromatherapy with lavender oil alone, and in combination with music, on pain and anxiety during extracorporeal shockwave lithotripsy for kidney stones.This was a single-centre prospective, randomised controlled trial. The subjects were block randomised into 3 study groups, Group 1: Control; Group 2: Aromatherapy only; Group 3: Aromatherapy and music. All subjects were given patient-controlled intravenous alfentanil as standard analgesia. The primary outcome measures were pain and anxiety scores using visual analogue scale (VAS) and State-Trait Anxiety Inventory.Ninety patients were recruited and randomised prospectively into Group 1 (n = 30), Group 2 (n = 30), and Group 3 (n = 30). For pain outcome, both Group 2 and Group 3 showed a trend towards lower mean VAS pain scores of 2.73 in both groups compared to the control with a mean VAS score of 3.50, but it was not statistically significant (p = 0.272). There was no significant difference in anxiety scores between groups post-treatment.Our study was unable to show a significant improvement in pain relief and anxiety when aromatherapy with lavender oil was added to standard analgesia alone during shockwave lithotripsy. There was also no difference when aromatherapy was combined with music.
rights: © 2023. The Author(s), under exclusive licence to Springer Nature B.V.
has PII: 10.1007/s11255-023-03684-0
doi: 10.1007/s11255-023-03684-0
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Law YXT
      type: Person
      first name: Yu Xi Terence
      last name: Law
      member of: Department of Urology, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore, 119228, Singapore. terencelaw83@gmail.com.
  slot:
    index: 2
    item: Kesavan A
      type: Person
      first name: Arshvin
      last name: Kesavan
      member of: Department of Urology, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore, 119228, Singapore.
  slot:
    index: 3
    item: Loke W
      type: Person
      first name: Wayren
      last name: Loke
      member of: Department of Urology, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore, 119228, Singapore.
  slot:
    index: 4
    item: Chua WJ
      type: Person
      first name: Wei Jin
      last name: Chua
      member of: Department of Urology, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore, 119228, Singapore.
  slot:
    index: 5
    item: Tai BC
      type: Person
      first name: Bee Choo
      last name: Tai
      member of: Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
  slot:
    index: 6
    item: Shen L
      type: Person
      first name: Liang
      last name: Shen
      member of: Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  slot:
    index: 7
    item: Tiong HY
      type: Person
      first name: Ho Yee
      last name: Tiong
      member of: Department of Urology, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore, 119228, Singapore.
  slot:
    index: 8
    item: Chen WJK
      type: Person
      first name: Wei Jing Kelven
      last name: Chen
      member of: Department of Urology, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 8, Singapore, 119228, Singapore.
created: 2023-7-3T13:06
date last updated: 2025-01-20
issued: 2023-10
dp: 2023 Oct
created: 2023-7-3T11:11
e ISSN: 1573-2584
has issn l: 0301-1623
issue: 10
has NLM journal title abbreviation: Int Urol Nephrol
publication name: International urology and nephrology
language: eng
has national library of medicine journal id: 0262521
derived from: NLM
starting page: 2405
ending page: 2410
has place of publication: Netherlands
has primary subject term: D009146
has primary subject term: D019341
has primary subject term: D009147
has primary subject term: D000698
has primary subject term: D008096Q000009
has subject term: D006801
has subject term: D059408
has subject term: D011446
has subject term: D010146Q000209Q000517
has subject term: D001007Q000209Q000628
source: Int Urol Nephrol. 2023-10;55(10):2405-2410.
volume: 55

Serologic differences between dermatomyositis and antisynthetase syndrome using a commercially available autoantibody panel: A retrospective cohort study.
pmid: 37391068
has PII: S0190-9622(23)01197-0
doi: 10.1016/j.jaad.2023.06.035
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Narayan N
      type: Person
      first name: Neha
      last name: Narayan
      member of: University of Rochester School of Medicine and Dentistry, Rochester, New York.
  slot:
    index: 2
    item: Richardson CT
      type: Person
      first name: Christopher T
      last name: Richardson
      member of: Department of Dermatology, University of Rochester Medical Center, Rochester, New York. Electronic address: crichardson@urmc.rochester.edu.
created: 2023-7-1T11:41
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2023-6-30T19:16
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
starting page: 311
ending page: 313
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):311-313.
volume: 92

Burden of serious harms from diagnostic error in the USA.
pmid: 37460118
abstract: Diagnostic errors cause substantial preventable harms worldwide, but rigorous estimates for total burden are lacking. We previously estimated diagnostic error and serious harm rates for key dangerous diseases in major disease categories and validated plausible ranges using clinical experts.We sought to estimate the annual US burden of serious misdiagnosis-related harms (permanent morbidity, mortality) by combining prior results with rigorous estimates of disease incidence.Cross-sectional analysis of US-based nationally representative observational data. We estimated annual incident vascular events and infections from 21.5 million (M) sampled US hospital discharges (2012-2014). Annual new cancers were taken from US-based registries (2014). Years were selected for coding consistency with prior literature. Disease-specific incidences for 15 major vascular events, infections and cancers ('Big Three' categories) were multiplied by literature-based rates to derive diagnostic errors and serious harms. We calculated uncertainty estimates using Monte Carlo simulations. Validity checks included sensitivity analyses and comparison with prior published estimates.Annual US incidence was 6.0 M vascular events, 6.2 M infections and 1.5 M cancers. Per 'Big Three' dangerous disease case, weighted mean error and serious harm rates were 11.1% and 4.4%, respectively. Extrapolating to all diseases (including non-'Big Three' dangerous disease categories), we estimated total serious harms annually in the USA to be 795 000 (plausible range 598 000-1 023 000). Sensitivity analyses using more conservative assumptions estimated 549 000 serious harms. Results were compatible with setting-specific serious harm estimates from inpatient, emergency department and ambulatory care. The 15 dangerous diseases accounted for 50.7% of total serious harms and the top 5 (stroke, sepsis, pneumonia, venous thromboembolism and lung cancer) accounted for 38.7%.An estimated 795 000 Americans become permanently [cell cut: 2215 characters, first 2000 kept]
rights: © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: bmjqs-2021-014130
doi: 10.1136/bmjqs-2021-014130
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Newman-Toker DE
      type: Person
      first name: David E
      last name: Newman-Toker
      member of: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA toker@jhu.edu.Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  slot:
    index: 2
    item: Nassery N
      type: Person
      first name: Najlla
      last name: Nassery
      member of: Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  slot:
    index: 3
    item: Schaffer AC
      type: Person
      first name: Adam C
      last name: Schaffer
      member of: Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.Department of Patient Safety, The Risk Management Foundation of the Harvard Medical Institutions Inc, Boston, Massachusetts, USA.
  slot:
    index: 4
    item: Yu-Moe CW
      type: Person
      first name: Chihwen Winnie
      last name: Yu-Moe
      member of: Department of Patient Safety, The Risk Management Foundation of the Harvard Medical Institutions Inc, Boston, Massachusetts, USA.
  slot:
    index: 5
    item: Clemens GD
      type: Person
      first name: Gwendolyn D
      last name: Clemens
      member of: Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  slot:
    index: 6
    item: Wang Z
      type: Person
      first name: Zheyu
      last name: Wang
      member of: Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  slot:
    index: 7
    item: Zhu Y
      type: Person
      first name: Yuxin
      last name: Zhu
      member of: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  slot:
    index: 8
    item: Saber Tehrani AS
      type: Person
      first name: Ali S
      last name: Saber Tehrani
      member of: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  slot:
    index: 9
    item: Fanai M
      type: Person
      first name: Mehdi
      last name: Fanai
      member of: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  slot:
    index: 10
    item: Hassoon A
      type: Person
      first name: Ahmed
      last name: Hassoon
      member of: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  slot:
    index: 11
    item: Siegal D
      type: Person
      first name: Dana
      last name: Siegal
      member of: Candello, The Risk Management Foundation of the Harvard Medical Institutions Inc, Boston, Massachusetts, USA.Department of Risk Management & Analytics, Coverys, Boston, Massachusetts, USA.
created: 2023-7-18T01:09
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2023-7-17T20:33
e ISSN: 2044-5423
has issn l: 2044-5415
issue: 2
has NLM journal title abbreviation: BMJ Qual Saf
publication name: BMJ quality & safety
language: eng
has national library of medicine journal id: 101546984
derived from: NLM
starting page: 109
ending page: 120
has place of publication: England
has primary subject term: D020521
has primary subject term: D008175
has subject term: D006801
has subject term: D014481Q000453
has subject term: D003430
has subject term: D009017
has subject term: D003951
source: BMJ Qual Saf. 2024-01-19;33(2):109-120.
volume: 33

Stress-induced Neuroinflammation of the Spinal Cord is Restrained by Cort113176 (Dazucorilant), A Specific Glucocorticoid Receptor Modulator.
pmid: 37566177
abstract: Glucocorticoids exert antiinflammatory, antiproliferative and immunosupressive effects. Paradoxically they may also enhance inflammation particularly in the nervous system, as shown in Cushing´ syndrome and neurodegenerative disorders of humans and models of human diseases. . The Wobbler mouse model of amyotrophic lateral sclerosis shows hypercorticoidism and neuroinflammation which subsided by treatment with the glucocorticoid receptor (GR) modulator Dazucorilant (CORT113176). This effect suggests that GR mediates the chronic glucocorticoid unwanted effects. We now tested this hypothesis using a chronic stress model resembling the condition of the Wobbler mouse Male NFR/NFR mice remained as controls or were subjected to a restraining / rotation stress protocol for 3 weeks, with a group of stressed mice receiving CORT113176 also for 3 weeks. We determined the mRNAS or reactive protein for the proinflamatory factors HMGB1, TLR4, NFkB, TNFα, markers of astrogliosis (GFAP, SOX9 and acquaporin 4), of microgliosis (Iba, CD11b, P2RY12 purinergic receptor) as well as serum IL1β and corticosterone. We showed that chronic stress produced high levels of serum corticosterone and IL1β, decreased body and spleen weight, produced microgliosis and astrogliosis and increased proinflammatory mediators. In stressed mice, modulation of the GR with CORT113176 reduced Iba + microgliosis, CD11b and P2RY12 mRNAs, immunoreactive HMGB1 + cells, GFAP + astrogliosis, SOX9 and acquaporin expression and TLR4 and NFkB mRNAs vs. stress-only mice. The effects of CORT113176 indicate that glucocorticoids are probably involved in neuroinflammation. Thus, modulation of the GR would become useful to dampen the inflammatory component of neurodegenerative disorders.
rights: © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
has PII: 10.1007/s12035-023-03554-x
doi: 10.1007/s12035-023-03554-x
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Meyer M
      type: Person
      first name: Maria
      last name: Meyer
      member of: Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Buenos Aires, Argentina.
  slot:
    index: 2
    item: Meijer O
      type: Person
      first name: Onno
      last name: Meijer
      member of: Dept. of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
  slot:
    index: 3
    item: Hunt H
      type: Person
      first name: Hazel
      last name: Hunt
      member of: Corcept Therapeutics, Menlo Park, Ca, USA.
  slot:
    index: 4
    item: Belanoff J
      type: Person
      first name: Joseph
      last name: Belanoff
      member of: Corcept Therapeutics, Menlo Park, Ca, USA.
  slot:
    index: 5
    item: Lima A
      type: Person
      first name: Analia
      last name: Lima
      member of: Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Buenos Aires, Argentina.
  slot:
    index: 6
    item: de Kloet ER
      type: Person
      first name: E Ronald
      last name: de Kloet
      member of: Dept. of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
  slot:
    index: 7
    item: Gonzalez Deniselle MC
      type: Person
      first name: Maria Claudia
      last name: Gonzalez Deniselle
      member of: Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Buenos Aires, Argentina.Dept. of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  slot:
    index: 8
    item: De Nicola AF
      type: Person
      first name: Alejandro F
      last name: De Nicola
      member of: Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Buenos Aires, Argentina. alejandrodenicola@gmail.com.Dept. of Human Biochemiistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina. alejandrodenicola@gmail.com.
created: 2023-8-11T12:43
date last updated: 2025-01-20
issued: 2024-01
dp: 2024 Jan
created: 2023-8-11T11:08
e ISSN: 1559-1182
has issn l: 0893-7648
issue: 1
has NLM journal title abbreviation: Mol Neurobiol
publication name: Molecular neurobiology
language: eng
has national library of medicine journal id: 8900963
derived from: NLM
starting page: 1
ending page: 14
has place of publication: United States
has primary subject term: D024243Q000378
has primary subject term: D019636Q000378
has primary subject term: D007546
has primary subject term: D011720
has subject term: D008297
has subject term: D051379
has subject term: D006801
has subject term: D000818
has subject term: D011965Q000378
has subject term: D003345
has subject term: http://id.nlm.nih.gov/mesh/D000090862
has subject term: D005911Q000378
has subject term: D051197Q000378
has subject term: D005938Q000494
has subject term: D013116Q000378
source: Mol Neurobiol. 2024-01;61(1):1-14.
volume: 61

Cinchonine and cinchonidine alleviate cisplatin-induced ototoxicity by regulating PI3K-AKT signaling.
pmid: 37577804
abstract: Cinchonine (CN) and its isomer cinchonidine (CD), two of the common cinchona alkaloids, are wildly used as antimalarial drugs. However, the effects of CN and CD on the auditory system are unknown.Molecular docking and molecular dynamics (MD) simulation were used for predicting effective drugs. The CCK-8 assay was conducted for assessing cell viability in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. MitoSox Red staining revealed reactive oxygen species (ROS) amounts. TMRM staining was used to assess the mitochondrial membrane potential (ΔΨm). Immunofluorescence staining of myosin 7a was used to examine hair cells (HCs) in cisplatin-treated neonatal mouse cochlear explants, while TUJ-1 immunostaining was used for the detection of spiral ganglion neurons (SGNs). Cleaved caspase-3 and TUNEL immunostaining were utilized for apoptosis assessment. Immunoblot was carried out to detect PI3K-AKT signaling effectors.Pretreatment with CN or CD significantly increased cell viability and reduced mitochondrial dysfunction and ROS accumulation in cisplatin-treated HEI-OC1 cells. Immunofluorescent staining of cochlear explants showed that CN and CD attenuated cisplatin-induced damage to SGNs and HCs. Immunoblot revealed that CN and CD downregulated the expression of cleaved caspase-3 and activated PI3K-AKT signaling in cisplatin-injured HEI-OC1 cells.CD and CN can reduce ototoxicity caused by cisplatin and might help treat cisplatin-associated hearing loss.
rights: © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.
doi: 10.1111/cns.14403
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Tang D
      type: Person
      first name: Dongmei
      last name: Tang
      member of: ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  slot:
    index: 2
    item: Wang X
      type: Person
      first name: Xue
      last name: Wang
      member of: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 3
    item: Wu J
      type: Person
      first name: Jingfang
      last name: Wu
      member of: ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  slot:
    index: 4
    item: Li Y
      type: Person
      first name: Yimeng
      last name: Li
      member of: ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  slot:
    index: 5
    item: Li C
      type: Person
      first name: Cai
      last name: Li
      member of: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 6
    item: Qiao X
      type: Person
      first name: Xiangyun
      last name: Qiao
      member of: Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
  slot:
    index: 7
    item: Fan L
      type: Person
      first name: Li
      last name: Fan
      member of: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 8
    item: Chen Y
      type: Person
      first name: Yutao
      last name: Chen
      member of: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 9
    item: Zhu H
      type: Person
      first name: Huanhuan
      last name: Zhu
      member of: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 10
    item: Zhang Z
      type: Person
      first name: Zhiyuan
      last name: Zhang
      member of: Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 11
    item: He Y
      type: Person
      first name: Yingzi
      last name: He
      member of: ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
created: 2023-8-14T06:41
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 02
created: 2023-8-14T05:27
e ISSN: 1755-5949
has issn l: 1755-5930
issue: 2
has NLM journal title abbreviation: CNS Neurosci Ther
publication name: CNS neuroscience & therapeutics
language: eng
has national library of medicine journal id: 101473265
derived from: NLM
pg: e14403
has place of publication: England
has primary subject term: D000970Q000633
has primary subject term: D000081015Q000188
has primary subject term: D002930Q000494
has subject term: D051379
has subject term: D000818
has subject term: D002945Q000633
has subject term: D051057Q000378
has subject term: D053148Q000378
has subject term: D019869
has subject term: D017382Q000378
has subject term: D062105
has subject term: D017209
source: CNS Neurosci Ther. 2024-02;30(2):e14403.
volume: 30

Bacteria- and fungus-derived PAMPs induce innate immune memory via similar functional, metabolic, and transcriptional adaptations.
pmid: 37793181
abstract: Exposure to pathogen-associated molecular patterns (PAMPs) induces an augmented, broad-spectrum antimicrobial response to subsequent infection, a phenomenon termed innate immune memory. This study examined the effects of treatment with β-glucan, a fungus-derived dectin-1 ligand, or monophosphoryl lipid A (MPLA), a bacteria-derived Toll-like receptor 4 ligand, on innate immune memory with a focus on identifying common cellular and molecular pathways activated by these diverse PAMPs. Treatment with either PAMP prepared the innate immune system to respond more robustly to Pseudomonas aeruginosa infection in vivo by facilitating mobilization of innate leukocytes into blood, recruitment of leukocytes to the site of infection, augmentation of microbial clearance, and attenuation of cytokine production. Examination of macrophages ex vivo showed amplification of metabolism, phagocytosis, and respiratory burst after treatment with either agent, although MPLA more robustly augmented these activities and more effectively facilitated killing of bacteria. Both agents activated gene expression pathways in macrophages that control inflammation, antimicrobial functions, and protein synthesis and suppressed pathways regulating cell division. β-glucan treatment minimally altered macrophage differential gene expression in response to lipopolysaccharide (LPS) challenge, whereas MPLA attenuated the magnitude of the LPS-induced transcriptional response, especially cytokine gene expression. These results show that β-glucan and MPLA similarly augment the innate response to infection in vivo. Yet, MPLA more potently induces alterations in macrophage metabolism, antimicrobial functions, gene transcription and the response to LPS.
rights: © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7289224
doi: 10.1093/jleuko/qiad120
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: McBride MA
      type: Person
      first name: Margaret A
      last name: McBride
      member of: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 2
    item: Stothers CL
      type: Person
      first name: Cody L
      last name: Stothers
      member of: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 3
    item: Fensterheim BA
      type: Person
      first name: Benjamin A
      last name: Fensterheim
      member of: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 4
    item: Caja KR
      type: Person
      first name: Katherine R
      last name: Caja
      member of: Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 5
    item: Owen AM
      type: Person
      first name: Allison M
      last name: Owen
      member of: Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 6
    item: Hernandez A
      type: Person
      first name: Antonio
      last name: Hernandez
      member of: Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 7
    item: Bohannon JK
      type: Person
      first name: Julia K
      last name: Bohannon
      member of: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 8
    item: Patil NK
      type: Person
      first name: Naeem K
      last name: Patil
      member of: Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 9
    item: Ali S
      type: Person
      first name: Sabah
      last name: Ali
      member of: Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 10
    item: Dalal S
      type: Person
      first name: Sujata
      last name: Dalal
      member of: Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.
  slot:
    index: 11
    item: Rahim M
      type: Person
      first name: Mohsin
      last name: Rahim
      member of: Department of Chemical and Biomolecular Engineering, Vanderbilt University, 2301 Vanderbilt Place, Nashville 37235, Tennessee.
  slot:
    index: 12
    item: Trenary IA
      type: Person
      first name: Irina A
      last name: Trenary
      member of: Department of Chemical and Biomolecular Engineering, Vanderbilt University, 2301 Vanderbilt Place, Nashville 37235, Tennessee.
  slot:
    index: 13
    item: Young JD
      type: Person
      first name: Jamey D
      last name: Young
      member of: Department of Chemical and Biomolecular Engineering, Vanderbilt University, 2301 Vanderbilt Place, Nashville 37235, Tennessee.Department of Molecular Physiology and Biophysics, Vanderbilt University, 2215 Garland Avenue, Nashville 37232, Tennessee.
  slot:
    index: 14
    item: Williams DL
      type: Person
      first name: David L
      last name: Williams
      member of: Department of Surgery, Quillen College of Medicine, East Tennessee State University, 325 North State of Franklin Road, Johnson City 37604, Tennessee.Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, 325 North State of Franklin Road, Johnson City 37604, Tennessee.
  slot:
    index: 15
    item: Sherwood ER
      type: Person
      first name: Edward R
      last name: Sherwood
      member of: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.Department of Anesthesiology, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville 37232, Tennessee.Department of Surgery, Quillen College of Medicine, East Tennessee State University, 325 North State of Franklin Road, Johnson City 37604, Tennessee.Center for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, 325 North State of Franklin Road, Johnson City 37604, Tennessee.
created: 2023-10-4T18:42
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2023-10-4T17:13
e ISSN: 1938-3673
has issn l: 0741-5400
issue: 2
has NLM journal title abbreviation: J Leukoc Biol
publication name: Journal of leukocyte biology
language: eng
has national library of medicine journal id: 8405628
derived from: NLM
starting page: 358
ending page: 373
has place of publication: England
has primary subject term: D047071Q000494
has primary subject term: D000890
has subject term: D008070Q000494
has subject term: http://id.nlm.nih.gov/mesh/D000069452
has subject term: http://id.nlm.nih.gov/mesh/D000094384
has subject term: D008024
has subject term: D016207
has subject term: D001419
has subject term: D007113
source: J Leukoc Biol. 2024-01-19;115(2):358-373.
volume: 115

Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges.
pmid: 37804835
abstract: Synthetic antisense oligonucleotides (ASOs) and duplex RNAs (dsRNAs) are an increasingly successful strategy for drug development. After a slow start, the pace of success has accelerated since the approval of Spinraza (nusinersen) in 2016 with several drug approvals. These accomplishments have been achieved even though oligonucleotides are large, negatively charged, and have little resemblance to traditional small-molecule drugs-a remarkable achievement of basic and applied science. The goal of this review is to summarize the foundation underlying recent progress and describe ongoing research programs that may increase the scope and impact of oligonucleotide therapeutics.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S2451-9456(23)00323-9
doi: 10.1016/j.chembiol.2023.09.005
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Hofman CR
      type: Person
      first name: Cristina R
      last name: Hofman
      member of: The Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.
  slot:
    index: 2
    item: Corey DR
      type: Person
      first name: David R
      last name: Corey
      member of: The Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA. Electronic address: david.corey@utsouthwestern.edu.
created: 2023-10-8T02:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2023-10-7T18:41
e ISSN: 2451-9448
has issn l: 2451-9448
issue: 1
has NLM journal title abbreviation: Cell Chem Biol
publication name: Cell chemical biology
language: eng
has national library of medicine journal id: 101676030
derived from: NLM
starting page: 125
ending page: 138
has place of publication: United States
has primary subject term: D012313
has primary subject term: D009841
has subject term: D016376Q000627Q000235
has subject term: http://id.nlm.nih.gov/mesh/D000076722
source: Cell Chem Biol. 2024-01-18;31(1):125-138.
volume: 31

Highly efficient cellular expression of circular mRNA enables prolonged protein expression.
pmid: 37883972
abstract: A major problem with mRNA therapeutics is that mRNA is usually degraded within a few hours after entering the cytosol. New approaches for in vitro synthesis of circular mRNA have allowed increased levels and duration of protein synthesis from mRNA therapeutics due to the long half-life of circular mRNA. However, it remains difficult to genetically encode circular mRNAs in mammalian cells. Here, we describe the adaptation of the Tornado (Twister-optimized RNA for durable overexpression) system to achieve in-cell synthesis of circular mRNAs. We screen different promoters and internal ribosomal entry sites (IRESs) and identify combinations that result in high levels of circular mRNA and protein expression. We show that these circular mRNAs can be packaged into virus-like particles (VLPs), thus enabling prolonged protein expression. Overall, these data describe a platform for synthesis of circular mRNAs and how these circular mRNAs can improve VLP therapeutics.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S2451-9456(23)00334-3
doi: 10.1016/j.chembiol.2023.09.015
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Unti MJ
      type: Person
      first name: Mildred J
      last name: Unti
      member of: Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
  slot:
    index: 2
    item: Jaffrey SR
      type: Person
      first name: Samie R
      last name: Jaffrey
      member of: Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Electronic address: srj2003@med.cornell.edu.
created: 2023-10-27T00:43
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2023-10-26T18:42
e ISSN: 2451-9448
has issn l: 2451-9448
issue: 1
has NLM journal title abbreviation: Cell Chem Biol
publication name: Cell chemical biology
language: eng
has national library of medicine journal id: 101676030
derived from: NLM
starting page: 163
ending page: 176.e5
has place of publication: United States
has primary subject term: D012313
has primary subject term: D014176
has subject term: D000818
has subject term: D012333Q000235
has subject term: D008322Q000235
source: Cell Chem Biol. 2024-01-18;31(1):163-176.e5.
volume: 31

Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
pmid: 37967558
abstract: A novel class of benzoxaboroles was reported to induce cancer cell death but the mechanism was unknown. Using a forward genetics platform, we discovered mutations in cleavage and polyadenylation specific factor 3 (CPSF3) that reduce benzoxaborole binding and confer resistance. CPSF3 is the endonuclease responsible for pre-mRNA 3'-end processing, which is also important for RNA polymerase II transcription termination. Benzoxaboroles inhibit this endonuclease activity of CPSF3 in vitro and also curb transcriptional termination in cells, which results in the downregulation of numerous constitutively expressed genes. Furthermore, we used X-ray crystallography to demonstrate that benzoxaboroles bind to the active site of CPSF3 in a manner distinct from the other known inhibitors of CPSF3. The benzoxaborole compound impeded the growth of cancer cell lines derived from different lineages. Our results suggest benzoxaboroles may represent a promising lead as CPSF3 inhibitors for clinical development.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S2451-9456(23)00380-X
doi: 10.1016/j.chembiol.2023.10.019
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Tao Y
      type: Person
      first name: Ye
      last name: Tao
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 2
    item: Budhipramono A
      type: Person
      first name: Albert
      last name: Budhipramono
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 3
    item: Huang J
      type: Person
      first name: Ji
      last name: Huang
      member of: Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  slot:
    index: 4
    item: Fang M
      type: Person
      first name: Min
      last name: Fang
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 5
    item: Xie S
      type: Person
      first name: Shanhai
      last name: Xie
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 6
    item: Kim J
      type: Person
      first name: Jiwoong
      last name: Kim
      member of: Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 7
    item: Khivansara V
      type: Person
      first name: Vishal
      last name: Khivansara
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, Program in Molecular Medicine and Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 8
    item: Dominski Z
      type: Person
      first name: Zbigniew
      last name: Dominski
      member of: Department of Biochemistry and Biophysics and Integrative Program in Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  slot:
    index: 9
    item: Tong L
      type: Person
      first name: Liang
      last name: Tong
      member of: Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: ltong@columbia.edu.
  slot:
    index: 10
    item: De Brabander JK
      type: Person
      first name: Jef K
      last name: De Brabander
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jef.debrabander@utsouthwestern.edu.
  slot:
    index: 11
    item: Nijhawan D
      type: Person
      first name: Deepak
      last name: Nijhawan
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, Program in Molecular Medicine and Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: deepak.nijhawan@utsouthwestern.edu.
created: 2023-11-16T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2023-11-15T18:42
e ISSN: 2451-9448
has issn l: 2451-9448
issue: 1
has NLM journal title abbreviation: Cell Chem Biol
publication name: Cell chemical biology
language: eng
has national library of medicine journal id: 101676030
derived from: NLM
starting page: 139
ending page: 149.e14
has place of publication: United States
has primary subject term: D039223Q000037Q000737
has primary subject term: D004720Q000037
has primary subject term: D012322Q000235Q000378
has primary subject term: D001896Q000737Q000494
has primary subject term: D000970Q000737Q000494
has primary subject term: D012323Q000187
has subject term: D006801
has subject term: D045744
source: Cell Chem Biol. 2024-01-18;31(1):139-149.e14.
volume: 31

Konjac glucomannan-based aerogels with excellent thermal stability and flame retardancy for thermal insulation application.
pmid: 37918590
abstract: Biomass aerogels are a promising kind of environment-friendly thermal insulation material. However, the flammability, poor water resistance, and thermal instability of biomass aerogels limit their applications. Herein, freeze-drying and thermal imidization were used to create konjac glucomannan (KGM), boron nitride (BN), and polyimide (PI)-based aerogels with a semi-interpenetrating network structure. The introduction of BN was beneficial to improve the mechanical properties and thermal stability of aerogels. The imidization process of PI improved the hydrophobicity, mechanical property, and flame retardancy of the aerogels. The synergistic effect of PI and BN reduced the peak heat release rate and total heat release rate of KGM-based aerogel by 55.8 % and 35 %, respectively, and endowed aerogel with good self-extinguishing performance. Moreover, the results of thermal conductivity and infrared thermal imaging demonstrated that the aerogels had excellent thermal insulation properties, and could effectively manage thermal energy over a wide range of temperatures. This study provides a simple method for the preparation of heat-insulating aerogel with high fire safety, which has broad application prospects in the field of energy saving and emission reduction.
rights: Copyright © 2023 Elsevier B.V. All rights reserved.
has PII: S0141-8130(23)04713-X
doi: 10.1016/j.ijbiomac.2023.127814
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Deng P
      type: Person
      first name: Pengpeng
      last name: Deng
      member of: Hubei Key Laboratory of Industry Microbiology, National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China.
  slot:
    index: 2
    item: Liu X
      type: Person
      first name: Xinping
      last name: Liu
      member of: Hubei Key Laboratory of Industry Microbiology, National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China.
  slot:
    index: 3
    item: Li Y
      type: Person
      first name: Yan
      last name: Li
      member of: Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science and Technology, Changsha 410114, China.
  slot:
    index: 4
    item: Zhang YF
      type: Person
      first name: Yue-Fei
      last name: Zhang
      member of: Hunan Provincial Key Laboratory of Cytochemistry, Changsha University of Science and Technology, Changsha 410114, China.
  slot:
    index: 5
    item: Wu K
      type: Person
      first name: Kao
      last name: Wu
      member of: Hubei Key Laboratory of Industry Microbiology, National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China.
  slot:
    index: 6
    item: Jiang F
      type: Person
      first name: Fatang
      last name: Jiang
      member of: Hubei Key Laboratory of Industry Microbiology, National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China; Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK. Electronic address: JIANGFT@mail.hbut.edu.cn.
created: 2023-11-3T00:42
date last updated: 2025-01-19
issued: 2024-01
dp: 2024 Jan
created: 2023-11-2T20:16
e ISSN: 1879-0003
has issn l: 0141-8130
issue: Pt 1
has NLM journal title abbreviation: Int J Biol Macromol
publication name: International journal of biological macromolecules
language: eng
has national library of medicine journal id: 7909578
derived from: NLM
pg: 127814
has place of publication: Netherlands
has primary subject term: D006358
has primary subject term: D008351
has subject term: D018533
has subject term: D005612
source: Int J Biol Macromol. 2024-01;254(Pt 1):127814.
volume: 254

Screening and investigation of a short antimicrobial peptide: AVGAV.
pmid: 37937966
abstract: Bacterial resistance to various drugs is a major problem concerning the field of antibacterial agents. Fortunately, peptides with antibacterial activity can alleviate this problem. In this study, a short peptide (AVGAV) with excellent antibacterial activity was successfully screened from a peptide library by a self-made membrane chromatographic packing. The AVGAV peptide exhibits good biocompatibility and is non-toxic and non-irritating, which ensures that it presents safe antibacterial effects. AVGAV promoted wound healing in a mouse wound bacterial infection model. Most importantly, as a synthetic antimicrobial peptide, AVGAV can alleviate the problem of bacterial resistance, thus improving its application potential. This study provides a solution to the existing and potential problem of bacterial resistance.
doi: 10.1039/d3tb01672b
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Cao Y
      type: Person
      first name: Yang
      last name: Cao
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.
  slot:
    index: 2
    item: Kang L
      type: Person
      first name: Linlin
      last name: Kang
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.
  slot:
    index: 3
    item: Wang Y
      type: Person
      first name: Yumei
      last name: Wang
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.
  slot:
    index: 4
    item: Ren Z
      type: Person
      first name: Zekai
      last name: Ren
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.
  slot:
    index: 5
    item: Wu H
      type: Person
      first name: Han
      last name: Wu
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.
  slot:
    index: 6
    item: Liu X
      type: Person
      first name: Xin
      last name: Liu
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.
  slot:
    index: 7
    item: Cong H
      type: Person
      first name: Hailin
      last name: Cong
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China.School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China.
  slot:
    index: 8
    item: Yu B
      type: Person
      first name: Bing
      last name: Yu
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China.
  slot:
    index: 9
    item: Shen Y
      type: Person
      first name: Youqing
      last name: Shen
      member of: College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China. conghailin@sdut.edu.cn.Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
created: 2023-11-8T12:43
date last updated: 2025-01-20
issued: 2023-11-22
dp: 2023 11 22
created: 2023-11-8T08:54
e ISSN: 2050-7518
has issn l: 2050-750X
issue: 45
has NLM journal title abbreviation: J Mater Chem B
publication name: Journal of materials chemistry. B
language: eng
has national library of medicine journal id: 101598493
derived from: NLM
starting page: 10941
ending page: 10955
has place of publication: England
has primary subject term: D023181Q000494Q000737
has primary subject term: D001424
has subject term: D051379
has subject term: D000818
has subject term: http://id.nlm.nih.gov/mesh/D000089882
has subject term: D000900Q000494Q000737
has subject term: D014945
source: J Mater Chem B. 2023-11-22;11(45):10941-10955.
volume: 11

Balancing patient benefits and environmental impacts of emollient ingredients: An ethical argument.
pmid: 37952567
has PII: S0190-9622(23)03188-2
doi: 10.1016/j.jaad.2023.11.006
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Gotschall JW
      type: Person
      first name: Jeromy W
      last name: Gotschall
      member of: Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  slot:
    index: 2
    item: Silva GS
      type: Person
      first name: Genevieve S
      last name: Silva
      member of: Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  slot:
    index: 3
    item: Grant-Kels JM
      type: Person
      first name: Jane M
      last name: Grant-Kels
      member of: Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut; Department of Dermatology, University of Florida, Gainesville, Florida. Electronic address: grant@uchc.edu.
created: 2023-11-13T00:42
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2023-11-12T19:12
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
starting page: 379
ending page: 380
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):379-380.
volume: 92

Alternative lengthening of telomeres: mechanism and the pathogenesis of cancer.
pmid: 37890990
abstract: Telomere maintenance and elongation allows cells to gain replicative immortality and evade cellular senescence during cancer development. While most cancers use telomerase to maintain telomere lengths, a subset of cancers engage the alternative lengthening of telomeres (ALT) pathway for telomere maintenance. ALT is present in 5%-10% of all cancers, although the prevalence is dramatically higher in certain cancer types, including complex karyotype sarcomas, isocitrate dehydrogenase-mutant astrocytoma (WHO grade II-IV), pancreatic neuroendocrine tumours, neuroblastoma and chromophobe hepatocellular carcinomas. ALT is maintained through a homology-directed DNA repair mechanism. Resembling break-induced replication, this aberrant process results in dramatic cell-to-cell telomere length heterogeneity, widespread chromosomal instability and chronic replication stress. Additionally, ALT-positive cancers frequently harbour inactivating mutations in either chromatin remodelling proteins (ATRX, DAXX and H3F3A) or DNA damage repair factors (SMARCAL1 and SLX4IP). ALT can readily be detected in tissue by assessing the presence of unique molecular characteristics, such as large ultrabright nuclear telomeric foci or partially single-stranded telomeric DNA circles (C-circles). Importantly, ALT has been validated as a robust diagnostic and prognostic biomarker for certain cancer types and may even be exploited as a therapeutic target via small molecular inhibitors and/or synthetic lethality approaches.
rights: © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: jcp-2023-209005
doi: 10.1136/jcp-2023-209005
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mori JO
      type: Person
      first name: Joakin O
      last name: Mori
      member of: Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  slot:
    index: 2
    item: Keegan J
      type: Person
      first name: Joshua
      last name: Keegan
      member of: Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  slot:
    index: 3
    item: Flynn RL
      type: Person
      first name: Rachel L
      last name: Flynn
      member of: Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  slot:
    index: 4
    item: Heaphy CM
      type: Person
      first name: Christopher M
      last name: Heaphy
      member of: Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA heaphyc@bu.edu.Pathology and Laboratory Medicine, Boston Medical Center, Boston, Massachusetts, USA.
created: 2023-10-28T11:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2023-10-27T21:23
e ISSN: 1472-4146
has issn l: 0021-9746
issue: 2
has NLM journal title abbreviation: J Clin Pathol
publication name: Journal of clinical pathology
language: eng
has national library of medicine journal id: 0376601
derived from: NLM
starting page: 82
ending page: 86
has place of publication: England
has primary subject term: D019098Q000235
has primary subject term: D009369Q000235
has subject term: D006801
has subject term: D059505
has subject term: D000075924Q000235
has subject term: D016615Q000235Q000378
has subject term: D004265Q000235
has subject term: D002352
source: J Clin Pathol. 2024-01-18;77(2):82-86.
volume: 77

Addressing patient requests for treatment of noninflamed seborrheic keratoses.
pmid: 38008411
has PII: S0190-9622(23)03225-5
doi: 10.1016/j.jaad.2023.11.025
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Huang C
      type: Person
      first name: Christina
      last name: Huang
      member of: Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: christinahuang1000@gmail.com.
  slot:
    index: 2
    item: Sangari A
      type: Person
      first name: Ayush
      last name: Sangari
      member of: Renaissance School of Medicine, Stony Brook University, Stony Brook, New York.
  slot:
    index: 3
    item: Stoff BK
      type: Person
      first name: Benjamin K
      last name: Stoff
      member of: Department of Dermatology, Emory University School of Medicine, Emory Center for Ethics, Emory University School of Medicine, Atlanta, Georgia.
created: 2023-11-27T00:43
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2023-11-26T19:29
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
starting page: 381
ending page: 382
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):381-382.
volume: 92

2'-OH as a universal handle for studying intracellular RNAs.
pmid: 37992716
abstract: RNA plays pivotal roles in most cellular processes, serving as both the traditional carrier of genetic information and as a key regulator of cellular functions. The advent of chemical technologies has contributed critically to the analysis of cellular RNA structures, functions, and interactions. Many of these methods and molecules involve the utilization of chemically reactive handles in RNAs, either introduced externally or inherent within the polymer itself. Among these handles, the 2'-hydroxyl (2'-OH) group has emerged as an exceptionally well-suited and general chemical moiety for the modification and profiling of RNAs in intracellular studies. In this review, we provide an overview of the recent advancements in intracellular applications of acylation at the 2'-OH group of RNA. We outline progress made in probing RNA structure and interactomes, controlling RNA function, RNA imaging, and analyzing RNA-small molecule interactions, all achieved in living cells through this simple chemical handle on the biopolymer.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S2451-9456(23)00383-5
doi: 10.1016/j.chembiol.2023.10.022
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Xiao L
      type: Person
      first name: Lu
      last name: Xiao
      member of: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
  slot:
    index: 2
    item: Fang L
      type: Person
      first name: Linglan
      last name: Fang
      member of: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
  slot:
    index: 3
    item: Kool ET
      type: Person
      first name: Eric T
      last name: Kool
      member of: Department of Chemistry, Stanford University, Stanford, CA 94305, USA; Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA. Electronic address: kool@stanford.edu.
created: 2023-11-23T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2023-11-22T18:42
e ISSN: 2451-9448
has issn l: 2451-9448
issue: 1
has NLM journal title abbreviation: Cell Chem Biol
publication name: Cell chemical biology
language: eng
has national library of medicine journal id: 101676030
derived from: NLM
starting page: 110
ending page: 124
has place of publication: United States
has primary subject term: D012313Q000378
has subject term: D009690
has subject term: D000215
source: Cell Chem Biol. 2024-01-18;31(1):110-124.
volume: 31

The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions.
pmid: 38053243
abstract: Recent study had deepened our knowledge of the mitochondrial dynamics to classify mitochondrial fission into two types. To further clarify the relationship between the two distinct fission machinery and the four major adaptors of Drp1, we propose a model of mechanism elucidating the multiple functions of phospho-Drp1 with its adaptors during cell cycle and providing in-depth insights into the molecular basis and evolutionary implications in depth. The model highlights not only the clustering characteristics of different phospho-Drp1 with respective subsets of mitochondrial pro-fission adaptors but also the correlation, crosstalk and shifting between different clustering of phosphorylated Drp1-adaptors during different key fission situations. Particularly, phospho-Drp1 (Ser616) couples with Mff/MiD51 to exert mitochondrial division and phospho-Drp1 (Ser637) couples with MiD49/Fis1 to execute mitophagy in M-phase. We then apply the model to address the relationship of mitochondrial dynamics to Parkinson's disease (PD) and carcinogenesis. Our proposed model is indeed compatible with current research results and pathological observations, providing promising directions for future treatment design.
doi: 10.1080/15384101.2023.2289753
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Wu NS
      type: Person
      first name: Nian-Siou
      last name: Wu
      member of: Department of Education, Hsin-Chu Branch, National Taiwan University Hospital, Hsinchu, Taiwan.PhD Program in Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
  slot:
    index: 2
    item: Ma IC
      type: Person
      first name: I-Chu
      last name: Ma
      member of: Division of Neurology, China Medical University Hospital, Taichung, Taiwan.
  slot:
    index: 3
    item: Lin YF
      type: Person
      first name: Yi-Fan
      last name: Lin
      member of: Department of Education, National Taiwan University Hospital, Taipei, Taiwan.
  slot:
    index: 4
    item: Ko HJ
      type: Person
      first name: Huey-Jiun
      last name: Ko
      member of: Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  slot:
    index: 5
    item: Loh JK
      type: Person
      first name: Joon-Khim
      last name: Loh
      member of: Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
  slot:
    index: 6
    item: Hong YR
      type: Person
      first name: Yi-Ren
      last name: Hong
      member of: Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Graduate Institutes of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
created: 2023-12-6T06:42
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-6T00:03
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2485
ending page: 2503
has place of publication: United States
has primary subject term: D034281Q000235Q000378
has primary subject term: D063154
has subject term: D002455
has subject term: D002453
has subject term: D024101Q000235Q000378
source: Cell Cycle. 2023-11;22(21-22):2485-2503.
volume: 22

Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
pmid: 38057958
abstract: Obesity poses significant health risks and can negatively impact an individual's quality of life. The human obesity phenotype results from the differentiation of pre-adipocytes into adipocytes, which leads to hypertrophy and hyperplasia in adipose tissue. The molecular mechanisms by which long non-coding RNAs (lncRNAs) modulate adipocyte differentiation, a process implicated in obesity development, remain poorly characterized. A lncRNA which suppressed the hepatic gluconeogenesis and lipogenesis (lncSHGL) was newly identified. Our research aims to elucidate the functional role and mechanistic underpinnings of suppressor of lncSHGL in adipocyte differentiation. We observed that lncSHGL expression progressively diminished during 3T3-L1 differentiation and was downregulated in the liver and perirenal adipose tissue of ob/ob mice. lncSHGL acts as a molecular sponge for miR-149, with Mospd3 identified as a target of miR-149.Overexpression of lncSHGL and inhibition of miR-149 led to suppressed 3T3-L1 proliferation, decreased lipid droplet accumulation, and attenuated promoter activity of PPARγ2 and C/EBPα. These changes consequently resulted in reduced expression of Cyclin D1, LPL, PPARγ2, AP2, and C/EBPα, as well as inhibited the PI3K/AKT/mTOR signaling pathway. In contrast, lncSHGL suppression yielded opposing outcomes. Moreover, the effects of lncSHGL overexpression and miR-149 inhibition on reduced expression of Cyclin D1, LPL, PPARγ2, AP2, and C/EBPα were reversible upon miR-149 overexpression and Mospd3 suppression. These findings were further validated in vivo. We also discovered a significant increase in methylation levels during 3T3-L1 differentiation, with lncSHGL highly expressed in the presence of a methylation inhibitor. In conclusion. lncSHGL methylation facilitates adipocyte differentiation by modulating the miR-149/Mospd3 axis. Targeting lncSHGL expression may represent a promising therapeutic strategy for obesity-associated adipogenesis, particularly in t[cell cut: 2034 characters, first 2000 kept]
doi: 10.1080/15384101.2023.2287367
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Huang X
      type: Person
      first name: Xianwei
      last name: Huang
      member of: Emergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.Emergency Department, Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, Xiamen, China.
  slot:
    index: 2
    item: Liu X
      type: Person
      first name: Xiong
      last name: Liu
      member of: Emergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.Emergency Department, Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, Xiamen, China.
  slot:
    index: 3
    item: Lin J
      type: Person
      first name: Jiyan
      last name: Lin
      member of: Emergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.Emergency Department, Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, Xiamen, China.
created: 2023-12-7T06:42
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-7T00:12
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2361
ending page: 2380
has place of publication: United States
has primary subject term: D019938Q000378
has primary subject term: D035683Q000235Q000378
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D041721
has subject term: D017667Q000378
has subject term: D050156Q000235
has subject term: D022763Q000235Q000378Q000494
has subject term: D002454
has subject term: D008745
has subject term: D009765Q000235Q000378
has subject term: D019869Q000378
has subject term: D047495Q000378
has subject term: D011788
source: Cell Cycle. 2023-11;22(21-22):2361-2380.
volume: 22

Epigenetic pioneering by SWI/SNF family remodelers.
pmid: 38016477
abstract: In eukaryotic genomes, transcriptional machinery and nucleosomes compete for binding to DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate chromatin accessibility for transcription factor (TF) and RNA polymerase binding. Recent structural studies have revealed multiple modes of TF engagement with nucleosomes, but how initial pioneering results in steady-state DNA accessibility for further TF binding and RNA polymerase II (RNAPII) engagement has been unclear. Even less well understood is how distant sites of open chromatin interact with one another, such as when developmental enhancers activate promoters to release RNAPII for productive elongation. Here, we review evidence for the centrality of the conserved SWI/SNF family of nucleosome remodeling complexes, both in pioneering and in mediating enhancer-promoter contacts. Consideration of the nucleosome unwrapping and ATP hydrolysis activities of SWI/SNF complexes, together with their architectural features, may reconcile steady-state TF occupancy with rapid TF dynamics observed by live imaging.
rights: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S1097-2765(23)00916-4
doi: 10.1016/j.molcel.2023.10.045
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ahmad K
      type: Person
      first name: Kami
      last name: Ahmad
      member of: Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  slot:
    index: 2
    item: Brahma S
      type: Person
      first name: Sandipan
      last name: Brahma
      member of: University of Nebraska Medical Center, Department of Genetics, Cell Biology & Anatomy, Omaha, NE, USA.
  slot:
    index: 3
    item: Henikoff S
      type: Person
      first name: Steven
      last name: Henikoff
      member of: Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: steveh@fredhutch.org.
created: 2023-11-29T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2023-11-28T18:42
e ISSN: 1097-4164
has issn l: 1097-2765
issue: 2
has NLM journal title abbreviation: Mol Cell
publication name: Molecular cell
language: eng
has national library of medicine journal id: 9802571
derived from: NLM
starting page: 194
ending page: 201
has place of publication: United States
has primary subject term: D009707Q000235
has primary subject term: D014157Q000235Q000378
has subject term: D002843
has subject term: D004268Q000235
has subject term: D012319Q000235Q000378
has subject term: D044127
has subject term: D042002
source: Mol Cell. 2024-01-18;84(2):194-201.
volume: 84

Short peripheral blood leukocyte telomere length in rheumatoid arthritis-interstitial lung disease.
pmid: 38071573
abstract: Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.
rights: © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
has PII: thorax-2023-220022
doi: 10.1136/thorax-2023-220022
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Doyle TJ
      type: Person
      first name: Tracy J
      last name: Doyle
      member of: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA tjdoyle@bwh.harvard.edu.
  slot:
    index: 2
    item: Juge PA
      type: Person
      first name: Pierre-Antoine
      last name: Juge
      member of: Université Paris Cité, INSERM UMR 1152, F-75018, Paris, France.Service de Rhumatologie, Hôpital Bichat-Claude Bernard, AP-HP, F-75018, Paris, France.
  slot:
    index: 3
    item: Peljto AL
      type: Person
      first name: Anna L
      last name: Peljto
      member of: Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, California, USA.
  slot:
    index: 4
    item: Lee S
      type: Person
      first name: Seoyeon
      last name: Lee
      member of: Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, California, USA.
  slot:
    index: 5
    item: Walts AD
      type: Person
      first name: Avram D
      last name: Walts
      member of: Department of Medicine, National Jewish Health, Denver, Colorado, USA.
  slot:
    index: 6
    item: Esposito AJ
      type: Person
      first name: Anthony Joseph
      last name: Esposito
      member of: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  slot:
    index: 7
    item: Poli S
      type: Person
      first name: Sergio
      last name: Poli
      member of: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 8
    item: Gill R
      type: Person
      first name: Ritu
      last name: Gill
      member of: Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  slot:
    index: 9
    item: Hatabu H
      type: Person
      first name: Hiroto
      last name: Hatabu
      member of: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 10
    item: Nishino M
      type: Person
      first name: Mizuki
      last name: Nishino
      member of: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 11
    item: Dellaripa PF
      type: Person
      first name: Paul F
      last name: Dellaripa
      member of: Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 12
    item: Weinblatt ME
      type: Person
      first name: Michael E
      last name: Weinblatt
      member of: Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 13
    item: Shadick NA
      type: Person
      first name: Nancy A
      last name: Shadick
      member of: Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 14
    item: Demoruelle MK
      type: Person
      first name: M Kristen
      last name: Demoruelle
      member of: Department of Medicine, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 15
    item: Sparks JA
      type: Person
      first name: Jeffrey A
      last name: Sparks
      member of: Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  slot:
    index: 16
    item: Rosas IO
      type: Person
      first name: Ivan O
      last name: Rosas
      member of: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 17
    item: Granger B
      type: Person
      first name: Benjamin
      last name: Granger
      member of: Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Hôpital Pitié Salpétrière, Public Health Department, F75013, Paris, France.
  slot:
    index: 18
    item: Deane KD
      type: Person
      first name: Kevin D
      last name: Deane
      member of: Department of Medicine, Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  slot:
    index: 19
    item: Crestani B
      type: Person
      first name: Bruno
      last name: Crestani
      member of: Université Paris Cité, INSERM UMR 1152, F-75018, Paris, France.Department of Pulmonology, Centre de Référence des Maladies Pulmonaires Rares, Hopital Bichat-Claude Bernard, APHP, Paris, France.
  slot:
    index: 20
    item: Wolters PJ
      type: Person
      first name: Paul J
      last name: Wolters
      member of: Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA.
  slot:
    index: 21
    item: Dieudé P
      type: Person
      first name: Philippe
      last name: Dieudé
      member of: Université Paris Cité, INSERM UMR 1152, F-75018, Paris, France.Service de Rhumatologie, Hôpital Bichat-Claude Bernard, AP-HP, F-75018, Paris, France.
  slot:
    index: 22
    item: Lee JS
      type: Person
      first name: Joyce S
      last name: Lee
      member of: Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA.
created: 2023-12-10T12:41
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2023-12-10T06:00
e ISSN: 1468-3296
has issn l: 0040-6376
issue: 2
has NLM journal title abbreviation: Thorax
publication name: Thorax
language: eng
has national library of medicine journal id: 0417353
derived from: NLM
starting page: 182
ending page: 185
has place of publication: England
has primary subject term: D001172Q000235Q000150
has primary subject term: D017563Q000150
has subject term: D006801
has subject term: D059506
has subject term: D016615Q000235
has subject term: D012907
source: Thorax. 2024-01-18;79(2):182-185.
volume: 79

Folate regulation of planar cell polarity pathway and F-actin through folate receptor alpha.
pmid: 38095297
abstract: Folate deficiency contribute to neural tube defects (NTDs) which could be rescued by folate supplementation. However, the underlying mechanisms are still not fully understood. Besides, there is considerable controversy concerning the forms of folate used for supplementation. To address this controversy, we prepared culture medium with different forms of folate, folic acid (FA), and 5-methyltetrahydrofolate (5mTHF), at concentrations of 5 μM, 500 nM, 50 nM, and folate free, respectively. Mouse embryonic fibroblasts (MEFs) were treated with different folates continuously for three passages, and cell proliferation and F-actin were monitored. We determined that compared to 5mTHF, FA showed stronger effects on promoting cell proliferation and F-actin formation. We also found that FOLR1 protein level was positively regulated by folate concentration and the non-canonical Wnt/planar cell polarity (PCP) pathway signaling was significantly enriched among different folate conditions in RNA-sequencing analyses. We demonstrated for the first time that FOLR1 could promote the transcription of Vangl2, one of PCP core genes. The transcription of Vangl2 was down-regulated under folate-deficient condition, which resulted in a decrease in PCP activity and F-actin formation. In summary, we identified a distinct advantage of FA in cell proliferation and F-actin formation over 5mTHF, as well as demonstrating that FOLR1 could promote transcription of Vangl2 and provide a new mechanism by which folate deficiency can contribute to the etiology of NTDs.
rights: © 2023 Federation of American Societies for Experimental Biology.
doi: 10.1096/fj.202300202R
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Han X
      type: Person
      first name: Xiao
      last name: Han
      member of: Department of Reproductive Medicine Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 2
    item: Cao X
      type: Person
      first name: Xuanye
      last name: Cao
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 3
    item: Cabrera RM
      type: Person
      first name: Robert M
      last name: Cabrera
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 4
    item: Ramirez PAP
      type: Person
      first name: Paula Andrea Pimienta
      last name: Ramirez
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 5
    item: Lin YL
      type: Person
      first name: Ying Linda
      last name: Lin
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 6
    item: Wlodarczyk BJ
      type: Person
      first name: Bogdan J
      last name: Wlodarczyk
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 7
    item: Zhang C
      type: Person
      first name: Cuilian
      last name: Zhang
      member of: Department of Reproductive Medicine Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China.
  slot:
    index: 8
    item: Finnell RH
      type: Person
      first name: Richard H
      last name: Finnell
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.Departments of Molecular and Human Genetics and Medicine, Baylor College of Medicine, Houston, Texas, USA.
  slot:
    index: 9
    item: Lei Y
      type: Person
      first name: Yunping
      last name: Lei
      member of: Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
created: 2023-12-14T12:41
date last updated: 2025-01-20
issued: 2024-01
dp: 2024 01
created: 2023-12-14T07:43
e ISSN: 1530-6860
has issn l: 0892-6638
issue: 1
has NLM journal title abbreviation: FASEB J
publication name: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
language: eng
has national library of medicine journal id: 8804484
derived from: NLM
pg: e23346
has place of publication: United States
has primary subject term: D009436Q000235Q000378
has primary subject term: D005494Q000378
has subject term: D000818
has subject term: D051379
has subject term: D005492Q000378
has subject term: D000199Q000378
has subject term: D058975Q000235Q000378
has subject term: D016764Q000235
has subject term: D005347Q000378
has subject term: D060449
source: FASEB J. 2024-01;38(1):e23346.
volume: 38

Multi-site lumbar transcutaneous spinal cord stimulation: When less is more.
pmid: 38096973
abstract: Transcutaneous spinal stimulation (TSS) has become a valuable tool for facilitating rehabilitation in individuals with neurological deficits. A significant constraint arises from the need for precise knowledge of stimulation locations to effectively apply TSS for targeted functional enhancement.In this study, we investigate whether single-site or simultaneous multi-site stimulation over the lumbar spinal cord is advantageous for recruitment of specific motor pools projecting to lower limb muscles and generates higher leg extensor forces in neurologically intact individuals. Tests were performed in a supine position. TSS was delivered at T10-T11, T11-T12, T12-L1, and L1-L2 intervertebral spaces individually, then through all four locations simultaneously. The peak-to-peak amplitude of spinally evoked motor potentials and the forces generated by lower limb muscles were compared at the common motor threshold intensity level across all stimulation conditions.Recruitment of motor pools projecting to proximal and distal lower limb muscles followed their topographical rostro-caudal arrangement along the lumbosacral enlargement. Single-site stimulation, apart from the T10-T11 location, resulted in larger responses in both proximal and distal muscles while also generating higher knee-extension and plantarflexion forces when compared to multi-site stimulation.Both motor response and force generation were reduced when using multi-site TSS when compared to single-site stimulation. This demonstrates that the segmental effects of TSS are important to consider when performing multi-site TSS.
rights: Copyright © 2023 Elsevier B.V. All rights reserved.
has PII: S0304-3940(23)00538-4
doi: 10.1016/j.neulet.2023.137579
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Tran K
      type: Person
      first name: Khue
      last name: Tran
      member of: School of Engineering Medicine, Texas A&M University, Houston, TX, USA.
  slot:
    index: 2
    item: Steele A
      type: Person
      first name: Alexander
      last name: Steele
      member of: Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
  slot:
    index: 3
    item: Crossnoe R
      type: Person
      first name: Remington
      last name: Crossnoe
      member of: Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
  slot:
    index: 4
    item: Martin C
      type: Person
      first name: Catherine
      last name: Martin
      member of: Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA.
  slot:
    index: 5
    item: Sayenko DG
      type: Person
      first name: Dimitry G
      last name: Sayenko
      member of: Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA. Electronic address: dgsayenko@houstonmethodist.org.
created: 2023-12-15T00:43
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2023-12-14T19:24
e ISSN: 1872-7972
has issn l: 0304-3940
has NLM journal title abbreviation: Neurosci Lett
publication name: Neuroscience letters
language: eng
has national library of medicine journal id: 7600130
derived from: NLM
pg: 137579
has place of publication: Ireland
has primary subject term: D062187Q000379
has subject term: D006801
has subject term: D018482Q000502
has subject term: D013116Q000502
has subject term: D035002
has subject term: D059408
source: Neurosci Lett. 2024-01-18;820():137579.
volume: 820

PSMC2 knockdown exerts an anti-tumor role in nasopharyngeal carcinoma through regulating AKT signaling pathway.
pmid: 38123344
abstract: Nasopharyngeal carcinoma is a major public health problem in several countries, particularly in Southeast Asia and North Africa. However, the mechanism underlying the malignant biological behaviors of nasopharyngeal carcinoma is not fully clear. Our study intended to investigate the functional importance and molecular mechanism of proteasome 26 S subunit ATPase 2 (PSMC2) in the progression of nasopharyngeal carcinoma. We examined the expression of PSMC2 in both nasopharyngeal carcinoma tissues and normal healthy tissues using immunohistochemistry (IHC). Additionally, we conducted a series of cell experiments to verify the functional roles of PSMC2 and to explore the underlying pathway involved. The results revealed that PSMC2 was significantly upregulated in nasopharyngeal carcinoma tissues compared to normal tissues. Moreover, high PSMC2 was shown to closely correlate with the pathological stage and tumor infiltrate in nasopharyngeal carcinoma patients. Functionally, we observed a suppression of nasopharyngeal carcinoma progression upon knocking down PSMC2. This was evidenced by inhibited cell proliferation and migration in vitro, as well as impaired cell growth in vivo, along with increased apoptosis. Mechanistically, the inhibitory effects of PSMC2 silence on nasopharyngeal carcinoma could be reversed by the addition of AKT activator. Overall, our study sheds light on a novel mechanism underlying the development and progression of nasopharyngeal carcinoma, with PSMC2 exerting a positive regulatory role through the modulation of the AKT signaling pathway. A deeper understanding of PSMC2 may contribute to the development of improved treatment strategies for nasopharyngeal carcinoma.
doi: 10.1080/15384101.2023.2293590
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Su J
      type: Person
      first name: Jin
      last name: Su
      member of: Department of Traditional Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, Henan, China.
  slot:
    index: 2
    item: Hu S
      type: Person
      first name: Shousen
      last name: Hu
      member of: Department of Throat Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, Henan, China.
  slot:
    index: 3
    item: Ding S
      type: Person
      first name: Shiping
      last name: Ding
      member of: Medical Service, Zhengzhou hospital of Traditional Chinese medicine, Zhengzhou, Henan, China.
  slot:
    index: 4
    item: Feng K
      type: Person
      first name: Kun
      last name: Feng
      member of: Department of Traditional Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, Henan, China.
created: 2023-12-21T00:41
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-20T21:05
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2381
ending page: 2391
has place of publication: United States
has primary subject term: D051057Q000378
has primary subject term: D009303Q000473
has subject term: D006801
has subject term: D000077274Q000473
has subject term: D045744
has subject term: D015398
has subject term: D049109Q000235
has subject term: D002465Q000235
has subject term: D015972
has subject term: D000074183Q000235
has subject term: D046988Q000378
source: Cell Cycle. 2023-11;22(21-22):2381-2391.
volume: 22

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
pmid: 38113892
abstract: Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular principles governing many important E3-E2 partnerships remain unknown, including those for RING-family GID/CTLH E3 ubiquitin ligases and their dedicated E2, Ubc8/UBE2H (yeast/human nomenclature). GID/CTLH-Ubc8/UBE2H-mediated ubiquitylation regulates biological processes ranging from yeast metabolic signaling to human development. Here, cryoelectron microscopy (cryo-EM), biochemistry, and cell biology reveal this exquisitely specific E3-E2 pairing through an unconventional catalytic assembly and auxiliary interactions 70-100 Å away, mediated by E2 multisite phosphorylation. Rather than dynamic polyelectrostatic interactions reported for other ubiquitylation complexes, multiple Ubc8/UBE2H phosphorylation sites within acidic CK2-targeted sequences specifically anchor the E2 C termini to E3 basic patches. Positions of phospho-dependent interactions relative to the catalytic domains correlate across evolution. Overall, our data show that phosphorylation-dependent multivalency establishes a specific E3-E2 partnership, is antagonistic with dephosphorylation, rigidifies the catalytic centers within a flexing GID E3-substrate assembly, and facilitates substrate collision with ubiquitylation active sites.
rights: Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
has PII: S1097-2765(23)00972-3
doi: 10.1016/j.molcel.2023.11.027
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Chrustowicz J
      type: Person
      first name: Jakub
      last name: Chrustowicz
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 2
    item: Sherpa D
      type: Person
      first name: Dawafuti
      last name: Sherpa
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 3
    item: Li J
      type: Person
      first name: Jerry
      last name: Li
      member of: Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA.
  slot:
    index: 4
    item: Langlois CR
      type: Person
      first name: Christine R
      last name: Langlois
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 5
    item: Papadopoulou EC
      type: Person
      first name: Eleftheria C
      last name: Papadopoulou
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany; Technical University of Munich, School of Natural Sciences, Munich 85748, Germany.
  slot:
    index: 6
    item: Vu DT
      type: Person
      first name: D Tung
      last name: Vu
      member of: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 7
    item: Hehl LA
      type: Person
      first name: Laura A
      last name: Hehl
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany; Technical University of Munich, School of Natural Sciences, Munich 85748, Germany.
  slot:
    index: 8
    item: Karayel Ö
      type: Person
      first name: Özge
      last name: Karayel
      member of: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 9
    item: Beier V
      type: Person
      first name: Viola
      last name: Beier
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 10
    item: von Gronau S
      type: Person
      first name: Susanne
      last name: von Gronau
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 11
    item: Müller J
      type: Person
      first name: Judith
      last name: Müller
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 12
    item: Prabu JR
      type: Person
      first name: J Rajan
      last name: Prabu
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 13
    item: Mann M
      type: Person
      first name: Matthias
      last name: Mann
      member of: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 14
    item: Kleiger G
      type: Person
      first name: Gary
      last name: Kleiger
      member of: Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA.
  slot:
    index: 15
    item: Alpi AF
      type: Person
      first name: Arno F
      last name: Alpi
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
  slot:
    index: 16
    item: Schulman BA
      type: Person
      first name: Brenda A
      last name: Schulman
      member of: Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany; Technical University of Munich, School of Natural Sciences, Munich 85748, Germany. Electronic address: schulman@biochem.mpg.de.
created: 2023-12-20T06:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2023-12-19T18:42
e ISSN: 1097-4164
has issn l: 1097-2765
issue: 2
has NLM journal title abbreviation: Mol Cell
publication name: Molecular cell
language: eng
has national library of medicine journal id: 9802571
derived from: NLM
starting page: 293
ending page: 308.e14
has place of publication: United States
has primary subject term: D044763Q000378
has primary subject term: D012441Q000235Q000378
has subject term: D006801
has subject term: D010766
has subject term: D020285
has subject term: D044767Q000378
has subject term: D054875
source: Mol Cell. 2024-01-18;84(2):293-308.e14.
volume: 84

Metabolic regulation of homologous recombination repair by MRE11 lactylation.
pmid: 38128537
abstract: Lactylation is a lactate-induced post-translational modification best known for its roles in epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetyltransferase in response to DNA damage and dependent on ATM phosphorylation of the latter. MRE11 lactylation promotes its binding to DNA, facilitating DNA end resection and HR. Inhibition of CBP or LDH downregulated MRE11 lactylation, impaired HR, and enhanced chemosensitivity of tumor cells in patient-derived xenograft and organoid models. A cell-penetrating peptide that specifically blocks MRE11 lactylation inhibited HR and sensitized cancer cells to cisplatin and PARPi. These findings unveil lactylation as a key regulator of HR, providing fresh insights into the ways in which cellular metabolism is linked to DSB repair. They also imply that the Warburg effect can confer chemoresistance through enhancing HR and suggest a potential therapeutic strategy of targeting MRE11 lactylation to mitigate the effects.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S0092-8674(23)01276-X
doi: 10.1016/j.cell.2023.11.022
creator: OrderedList
  length: 27
  slot:
    index: 1
    item: Chen Y
      type: Person
      first name: Yuping
      last name: Chen
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 2
    item: Wu J
      type: Person
      first name: Jinhuan
      last name: Wu
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 3
    item: Zhai L
      type: Person
      first name: Linhui
      last name: Zhai
      member of: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing, China.
  slot:
    index: 4
    item: Zhang T
      type: Person
      first name: Tingting
      last name: Zhang
      member of: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 5
    item: Yin H
      type: Person
      first name: Hui
      last name: Yin
      member of: Department of Thoracic Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang 422001, China.
  slot:
    index: 6
    item: Gao H
      type: Person
      first name: Huanyao
      last name: Gao
      member of: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
  slot:
    index: 7
    item: Zhao F
      type: Person
      first name: Fei
      last name: Zhao
      member of: Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
  slot:
    index: 8
    item: Wang Z
      type: Person
      first name: Zhe
      last name: Wang
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 9
    item: Yang X
      type: Person
      first name: Xiaoning
      last name: Yang
      member of: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 10
    item: Jin M
      type: Person
      first name: Mingpeng
      last name: Jin
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 11
    item: Huang B
      type: Person
      first name: Bingsong
      last name: Huang
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 12
    item: Ding X
      type: Person
      first name: Xin
      last name: Ding
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 13
    item: Li R
      type: Person
      first name: Rui
      last name: Li
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 14
    item: Yang J
      type: Person
      first name: Jie
      last name: Yang
      member of: Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
  slot:
    index: 15
    item: He Y
      type: Person
      first name: Yiming
      last name: He
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 16
    item: Wang Q
      type: Person
      first name: Qianwen
      last name: Wang
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 17
    item: Wang W
      type: Person
      first name: Weibin
      last name: Wang
      member of: Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
  slot:
    index: 18
    item: Kloeber JA
      type: Person
      first name: Jake A
      last name: Kloeber
      member of: Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA; Mayo Clinic Medical Scientist Training Program, Mayo Clinic Alix School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
  slot:
    index: 19
    item: Li Y
      type: Person
      first name: Yunxuan
      last name: Li
      member of: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 20
    item: Hao B
      type: Person
      first name: Bingbing
      last name: Hao
      member of: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing, China.
  slot:
    index: 21
    item: Zhang Y
      type: Person
      first name: Yuanyuan
      last name: Zhang
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
  slot:
    index: 22
    item: Wang J
      type: Person
      first name: Jiadong
      last name: Wang
      member of: Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
  slot:
    index: 23
    item: Tan M
      type: Person
      first name: Minjia
      last name: Tan
      member of: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing, China.
  slot:
    index: 24
    item: Li K
      type: Person
      first name: Ke
      last name: Li
      member of: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  slot:
    index: 25
    item: Wang P
      type: Person
      first name: Ping
      last name: Wang
      member of: Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Shanghai 200072, China.
  slot:
    index: 26
    item: Lou Z
      type: Person
      first name: Zhenkun
      last name: Lou
      member of: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA; Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
  slot:
    index: 27
    item: Yuan J
      type: Person
      first name: Jian
      last name: Yuan
      member of: State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200120, China. Electronic address: yuanjian229@hotmail.com.
created: 2023-12-22T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2023-12-21T18:42
e ISSN: 1097-4172
has issn l: 0092-8674
issue: 2
has NLM journal title abbreviation: Cell
publication name: Cell
language: eng
has national library of medicine journal id: 0413066
derived from: NLM
starting page: 294
ending page: 311.e21
has place of publication: United States
has primary subject term: D004268Q000378
has primary subject term: D000076228Q000378
has primary subject term: D059767
has subject term: D006801
has subject term: D004247
has subject term: D053903
has subject term: D004260
has subject term: D044127
has subject term: D059765
has subject term: D019344Q000378
source: Cell. 2024-01-18;187(2):294-311.e21.
volume: 187

Ethical issues of patient images freely accessible on the internet.
pmid: 38127012
has PII: S0190-9622(23)03230-9
doi: 10.1016/j.jaad.2023.11.028
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Ragi SD
      type: Person
      first name: Sara D
      last name: Ragi
      member of: Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: sara_ragi@brown.edu.
  slot:
    index: 2
    item: Shah A
      type: Person
      first name: Asghar
      last name: Shah
      member of: Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  slot:
    index: 3
    item: Grant-Kels JM
      type: Person
      first name: Jane M
      last name: Grant-Kels
      member of: Dermatology Department, University of Connecticut School of Medicine, Farmington, Connecticut; Dermatology Department, University of Florida College of Medicine, Gainesville, Florida.
  slot:
    index: 4
    item: Bercovitch L
      type: Person
      first name: Lionel
      last name: Bercovitch
      member of: Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.
created: 2023-12-21T12:43
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2023-12-21T10:35
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
starting page: 383
ending page: 384
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):383-384.
volume: 92

Identification of novel potential homologous repair deficiency-associated genes in pancreatic adenocarcinoma via WGCNA coexpression network analysis and machine learning.
pmid: 38124367
abstract: Homologous repair deficiency (HRD) impedes double-strand break repair, which is a common driver of carcinogenesis. Positive HRD status can be used as theranostic markers of response to platinum- and PARP inhibitor-based chemotherapies. Here, we aimed to fully investigate the therapeutic and prognostic potential of HRD in pancreatic adenocarcinoma (PAAD) and identify effective biomarkers related to HRD using comprehensive bioinformatics analysis. The HRD score was defined as the unweighted sum of the LOH, TAI, and LST scores, and it was obtained based on the previous literature. To characterize PAAD immune infiltration subtypes, the ConsensusClusterPlus package in R was used to conduct unsupervised clustering. A WGCNA was conducted to elucidate the gene coexpression modules and hub genes in the HRD-related gene module of PAAD. The functional enrichment study was performed using Metascape. LASSO analysis was performed using the glmnet package in R, while the random forest algorithm was realized using the randomForest package in R. The prognostic variables were evaluated using univariate Cox analysis. The prognostic risk model was built using the LASSO approach. ROC curve and KM survival analyses were performed to assess the prognostic potential of the risk model. The half-maximal inhibitory concentration (IC50) of the PARP inhibitors was estimated using the pRRophetic package in R and the Genomics of Drug Sensitivity in Cancer database. The rms package in R was used to create the nomogram. A high HRD score indicated a poor prognosis and an advanced clinical process in PAAD patients. PAAD tumors with high HRD levels revealed significant T helper lymphocyte depletion, upregulated levels of cancer stem cells, and increased sensitivity to rucaparib, Olaparib, and veliparib. Using WGCNA, 11 coexpression modules were obtained. The red module and 122 hub genes were identified as the most correlated with HRD in PAAD. Functional enrichment analysis revealed that the 122 hub ge[cell cut: 3020 characters, first 2000 kept]
doi: 10.1080/15384101.2023.2293594
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Liu C
      type: Person
      first name: Chun
      last name: Liu
      member of: Department of General surgery, The People's Hospital of Chizhou, Chizhou, Anhui Province, China.
  slot:
    index: 2
    item: Fang J
      type: Person
      first name: Jingyun
      last name: Fang
      member of: Department of Nursing, The People's Hospital of Chizhou, Chizhou, Anhui Province, China.
  slot:
    index: 3
    item: Kang W
      type: Person
      first name: Weibiao
      last name: Kang
      member of: Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
  slot:
    index: 4
    item: Yang Y
      type: Person
      first name: Yang
      last name: Yang
      member of: Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
  slot:
    index: 5
    item: Yu C
      type: Person
      first name: Changjun
      last name: Yu
      member of: Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
  slot:
    index: 6
    item: Chen H
      type: Person
      first name: Hao
      last name: Chen
      member of: Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
  slot:
    index: 7
    item: Zhang Y
      type: Person
      first name: Yongwei
      last name: Zhang
      member of: Department of general surgery, Anqing First People's Hospital, Anqing, Anhui Province, China.
  slot:
    index: 8
    item: Ouyang H
      type: Person
      first name: Huan
      last name: Ouyang
      member of: Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
created: 2023-12-21T06:42
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-21T02:20
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2392
ending page: 2408
has place of publication: United States
has primary subject term: D000230Q000235
has primary subject term: D010190Q000235
has subject term: D006801
has subject term: D018816
has subject term: http://id.nlm.nih.gov/mesh/D000069550
has subject term: D015415
source: Cell Cycle. 2023-11;22(21-22):2392-2408.
volume: 22

IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors.
pmid: 38103559
abstract: Compounds binding to the bromodomains of bromodomain and extra-terminal (BET) family proteins, particularly BRD4, are promising anticancer agents. Nevertheless, side effects and drug resistance pose significant obstacles in BET-based therapeutics development. Using high-throughput screening of a 200,000-compound library, we identified small molecules targeting a phosphorylated intrinsically disordered region (IDR) of BRD4 that inhibit phospho-BRD4 (pBRD4)-dependent human papillomavirus (HPV) genome replication in HPV-containing keratinocytes. Proteomic profiling identified two DNA damage response factors-53BP1 and BARD1-crucial for differentiation-associated HPV genome amplification. pBRD4-mediated recruitment of 53BP1 and BARD1 to the HPV origin of replication occurs in a spatiotemporal and BRD4 long (BRD4-L) and short (BRD4-S) isoform-specific manner. This recruitment is disrupted by phospho-IDR-targeting compounds with little perturbation of the global transcriptome and BRD4 chromatin landscape. The discovery of these protein-protein interaction inhibitors (PPIi) not only demonstrates the feasibility of developing PPIi against phospho-IDRs but also uncovers antiviral agents targeting an epigenetic regulator essential for virus-host interaction and cancer development.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S1097-2765(23)00967-X
doi: 10.1016/j.molcel.2023.11.022
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Wu SY
      type: Person
      first name: Shwu-Yuan
      last name: Wu
      member of: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 2
    item: Lai HT
      type: Person
      first name: Hsien-Tsung
      last name: Lai
      member of: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 3
    item: Sanjib Banerjee N
      type: Person
      first name: N
      last name: Sanjib Banerjee
      member of: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  slot:
    index: 4
    item: Ma Z
      type: Person
      first name: Zonghui
      last name: Ma
      member of: Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
  slot:
    index: 5
    item: Santana JF
      type: Person
      first name: Juan F
      last name: Santana
      member of: Department of Biochemistry and Molecular Biology, The University of Iowa, Iowa City, IA 52242, USA.
  slot:
    index: 6
    item: Wei S
      type: Person
      first name: Shuguang
      last name: Wei
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 7
    item: Liu X
      type: Person
      first name: Xisheng
      last name: Liu
      member of: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  slot:
    index: 8
    item: Zhang M
      type: Person
      first name: Meirong
      last name: Zhang
      member of: State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
  slot:
    index: 9
    item: Zhan J
      type: Person
      first name: Jian
      last name: Zhan
      member of: State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
  slot:
    index: 10
    item: Chen H
      type: Person
      first name: Haiying
      last name: Chen
      member of: Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
  slot:
    index: 11
    item: Posner B
      type: Person
      first name: Bruce
      last name: Posner
      member of: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  slot:
    index: 12
    item: Chen Y
      type: Person
      first name: Yadong
      last name: Chen
      member of: State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
  slot:
    index: 13
    item: Price DH
      type: Person
      first name: David H
      last name: Price
      member of: Department of Biochemistry and Molecular Biology, The University of Iowa, Iowa City, IA 52242, USA.
  slot:
    index: 14
    item: Chow LT
      type: Person
      first name: Louise T
      last name: Chow
      member of: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  slot:
    index: 15
    item: Zhou J
      type: Person
      first name: Jia
      last name: Zhou
      member of: Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA. Electronic address: jizhou@utmb.edu.
  slot:
    index: 16
    item: Chiang CM
      type: Person
      first name: Cheng-Ming
      last name: Chiang
      member of: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: cheng-ming.chiang@utsouthwestern.edu.
created: 2023-12-17T09:44
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2023-12-16T18:42
e ISSN: 1097-4164
has issn l: 1097-2765
issue: 2
has NLM journal title abbreviation: Mol Cell
publication name: Molecular cell
language: eng
has national library of medicine journal id: 9802571
derived from: NLM
starting page: 202
ending page: 220.e15
has place of publication: United States
has primary subject term: D014157Q000235Q000378
has primary subject term: D030361Q000188Q000235
has subject term: D006801
has subject term: D009687Q000235Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000094302
has subject term: D040901
has subject term: D018797Q000235Q000378
has subject term: D027383Q000235Q000378
has subject term: D014764Q000235
has subject term: D014779Q000502
has subject term: D004260
has subject term: http://id.nlm.nih.gov/mesh/D000092468
source: Mol Cell. 2024-01-18;84(2):202-220.e15.
volume: 84

Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury.
pmid: 38141752
abstract: Magnetic resonance imaging plays an important role in characterizing microstructural changes and reorganization after traumatic injuries to the nervous system. In this study, we tested the feasibility of ex-vivo spinal cord diffusion tensor imaging (DTI) in combination with in vivo brain functional MRI to characterize spinal reorganization and its supraspinal association after a hemicontusion cervical spinal cord injury (SCI). DTI parameters (fractional anisotropy [FA], mean diffusion [MD]) and fiber orientation changes related to reorganization in the contused cervical spinal cord were compared to sham specimens. Altered fiber density and fiber directions occurred across the ipsilateral and contralateral hemicords but with only ipsilateral FA and MD changes. The hemicontusion SCI resulted in ipsilateral fiber breaks, voids and vivid fiber reorientations along the injury epicenter. Fiber directional changes below the injury level were primarily inter-hemispheric, indicating prominent below-level cross-hemispheric reorganization. In vivo resting state functional connectivity of the brain from the respective rats before obtaining the spinal cord samples indicated spatial expansion and increased connectivity strength across both the sensory and motor networks after SCI. The consistency of the neuroplastic changes along the neuraxis (both brain and spinal cord) at the single-subject level, indicates that distinctive reorganizational relationships exist between the spinal cord and the brain post-SCI.
rights: Copyright © 2023 Elsevier B.V. All rights reserved.
has PII: S0304-3940(23)00566-9
doi: 10.1016/j.neulet.2023.137607
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Mihailovic JM
      type: Person
      first name: Jelena M
      last name: Mihailovic
      member of: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 300 Cedar St, New Haven, CT 06520, United States. Electronic address: jelena.mihailovic@yale.edu.
  slot:
    index: 2
    item: Sanganahalli BG
      type: Person
      first name: Basavaraju G
      last name: Sanganahalli
      member of: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 300 Cedar St, New Haven, CT 06520, United States. Electronic address: basavaraju.ganganna@yale.edu.
  slot:
    index: 3
    item: Hyder F
      type: Person
      first name: Fahmeed
      last name: Hyder
      member of: Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 300 Cedar St, New Haven, CT 06520, United States. Electronic address: fahmeed.hyder@yale.edu.
  slot:
    index: 4
    item: Chitturi J
      type: Person
      first name: Jyothsna
      last name: Chitturi
      member of: Department of Radiology, Rutgers Biomedical and Health Sciences-New Jersey Medical School, 30 Bergen Street, Newark, NJ 07103, United States.
  slot:
    index: 5
    item: Elkabes S
      type: Person
      first name: Stella
      last name: Elkabes
      member of: Department of Neurosurgery, Rutgers Biomedical and Health Sciences-New Jersey Medical School. 205 South Orange Avenue, Newark, NJ 07103, United States. Electronic address: elkabest@njms.rutgers.edu.
  slot:
    index: 6
    item: Heary RF
      type: Person
      first name: Robert F
      last name: Heary
      member of: Division of Neurosurgery, Hackensack Meridian School of Medicine, Mountainside Medical Center, Montclair, NJ, United States. Electronic address: robert.heary@mountainsidehosp.com.
  slot:
    index: 7
    item: Kannurpatti SS
      type: Person
      first name: Sridhar S
      last name: Kannurpatti
      member of: Department of Radiology, Rutgers Biomedical and Health Sciences-New Jersey Medical School, 30 Bergen Street, Newark, NJ 07103, United States. Electronic address: kannursr@njms.rutgers.edu.
created: 2023-12-24T09:41
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2023-12-23T19:25
e ISSN: 1872-7972
has issn l: 0304-3940
has NLM journal title abbreviation: Neurosci Lett
publication name: Neuroscience letters
language: eng
has national library of medicine journal id: 7600130
derived from: NLM
pg: 137607
has place of publication: Ireland
has primary subject term: D066193Q000293Q000473
has primary subject term: D013119Q000473
has subject term: D051381
has subject term: D000818
has subject term: D056324Q000379
has subject term: D013116Q000473
has subject term: D008279
source: Neurosci Lett. 2024-01-18;820():137607.
volume: 820

Metabolic Usage and Glycan Destinations of GlcNAz in E. coli.
pmid: 38146215
abstract: Bacteria use a diverse range of carbohydrates to generate a profusion of glycans, with amino sugars, such as N-acetylglucosamine (GlcNAc), being prevalent in the cell wall and in many exopolysaccharides. The primary substrate for GlcNAc-containing glycans, UDP-GlcNAc, is the product of the bacterial hexosamine pathway and a key target for bacterial metabolic glycan engineering. Using the strategy of expressing NahK, to circumvent the hexosamine pathway, it is possible to directly feed the analogue of GlcNAc, N-azidoacetylglucosamine (GlcNAz), for metabolic labeling in Escherichia coli. The cytosolic production of UDP-GlcNAz was confirmed by using fluorescence-assisted polyacrylamide gel electrophoresis. The key question of where GlcNAz is incorporated was interrogated by analyzing potential sites including peptidoglycan (PGN), the biofilm-related exopolysaccharide poly-β-1,6-N-acetylglucosamine (PNAG), lipopolysaccharide (LPS), and the enterobacterial common antigen (ECA). The highest levels of incorporation were observed in PGN with lower levels in PNAG and no observable incorporation in LPS or ECA. The promiscuity of the PNAG synthase (PgaCD) toward UDP-GlcNAz in vitro and the lack of undecaprenyl-pyrophosphoryl-GlcNAz intermediates generated in vivo confirmed the incorporation preferences. The results of this work will guide the future development of carbohydrate-based probes and metabolic engineering strategies.
doi: 10.1021/acschembio.3c00501
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Eddenden A
      type: Person
      first name: Alexander
      last name: Eddenden
      member of: Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
  slot:
    index: 2
    item: Dooda MK
      type: Person
      first name: Manoj K
      last name: Dooda
      member of: Department of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.
  slot:
    index: 3
    item: Morrison ZA
      type: Person
      first name: Zachary A
      last name: Morrison
      member of: Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
  slot:
    index: 4
    item: Shankara Subramanian A
      type: Person
      first name: Adithya
      last name: Shankara Subramanian
      member of: Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 0A4, Canada.
  slot:
    index: 5
    item: Howell PL
      type: Person
      first name: P Lynne
      last name: Howell
      member of: Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 0A4, Canada.
  slot:
    index: 6
    item: Troutman JM
      type: Person
      first name: Jerry M
      last name: Troutman
      member of: Department of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.
  slot:
    index: 7
    item: Nitz M
      type: Person
      first name: Mark
      last name: Nitz
      member of: Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.
created: 2023-12-26T06:41
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2023-12-26T02:23
e ISSN: 1554-8937
has issn l: 1554-8929
issue: 1
has NLM journal title abbreviation: ACS Chem Biol
publication name: ACS chemical biology
language: eng
has national library of medicine journal id: 101282906
derived from: NLM
starting page: 69
ending page: 80
has place of publication: United States
has primary subject term: D004926Q000378
has primary subject term: D008070
has subject term: D000117Q000378
has subject term: D011135
has subject term: D010457
has subject term: D014530
source: ACS Chem Biol. 2024-01-19;19(1):69-80.
volume: 19

SMAD7 gene polymorphisms and their influence on patients with colorectal cancer.
pmid: 38146644
abstract: Colorectal cancer (CRC) is a prevalent malignant tumor, and its pathogenesis is still not fully understood. Studies have shown that SMAD7 gene polymorphisms can affect CRC susceptibility, but the results have been inconsistent and require additional confirmation. Our study aimed to evaluate the effect of SMAD7 variants on the risk of CRC in the Chinese Han population. A total of five single nucleotide polymorphisms (SNPs) in SMAD7 were genotyped among 696 CRC patients and 696 healthy participants using the MassARRAY iPLEX platform. SNPs were evaluated for their associations with CRC using logistic regression analysis under multiple genetic models. The false-positive report probability (FPRP) analysis was used to validate the positive findings. Our study indicated that rs11874392 showed an increased association with CRC risk (odds ratio, 1.31; 95% confidence interval, 1.04-1.67; p = 0.024). Stratified analysis showed that rs11874392 might increase the risk of CRC in females (OR = 1.70, p = 0.028), individuals with smoking (OR = 1.87, p = 0.026), and drinking (OR = 1.38, p = 0.027). The rs11874392 was found to be related to an elevated risk of rectal cancer (OR = 1.73, p = 0.003), but not with colon cancer. FPRP analysis demonstrated that all of these associations were statistically significant (FPRP <0.2). Additionally, rs11874392 was the strongest predictive model for CRC. This study provides evidence that the SMAD7 rs11874392 is related to an increased susceptibility to CRC.
doi: 10.1080/15384101.2023.2296210
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Wu Y
      type: Person
      first name: Yongsheng
      last name: Wu
      member of: Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 2
    item: Xu J
      type: Person
      first name: Jue
      last name: Xu
      member of: Department of Intrarenal Rheumatology and Immunology, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 3
    item: Tan B
      type: Person
      first name: Biaobin
      last name: Tan
      member of: The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 4
    item: Yi T
      type: Person
      first name: Ting
      last name: Yi
      member of: The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 5
    item: Liu S
      type: Person
      first name: Su
      last name: Liu
      member of: The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 6
    item: Yang G
      type: Person
      first name: Guang
      last name: Yang
      member of: The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 7
    item: Li K
      type: Person
      first name: Kai
      last name: Li
      member of: The Second Ward of Oncology and Hematology Department, The People's Hospital of XiangXiang, Xiangxiang, China.
  slot:
    index: 8
    item: Zhao X
      type: Person
      first name: Xinhan
      last name: Zhao
      member of: Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
created: 2023-12-26T06:41
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-26T05:28
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2424
ending page: 2435
has place of publication: United States
has primary subject term: D020022
has primary subject term: D015179Q000235Q000473
has subject term: D005260
has subject term: D006801
has subject term: D005838
has subject term: D012306
has subject term: D020641Q000235
has subject term: D016022
has subject term: D051906Q000235
source: Cell Cycle. 2023-11;22(21-22):2424-2435.
volume: 22

SIRT1 alleviates insulin resistance and respiratory distress in late preterm rats by activating QKI5-mediated PPARγ/PI3K/AKT pathway.
pmid: 38146686
abstract: Neonatal respiratory distress syndrome (NRDS) is a common complication of gestational diabetes mellitus (GDM) and late preterm births. Research suggests that SIRT1 was involved in LPS-induced acute respiratory distress syndrome, but its mechanism remains to be further explored. Here, pregnant rats were intraperitoneally injected with 45 mg/Kg streptozotocin at day 0 of gestation to induce GDM and injected with LPS at day 17 of gestation to induce late preterm birth. Pioglitazone (a PPARγ agonist) was administered from day 17 to parturition in GDM group, and it was administered for 3 days before LPS injection in late preterm birth group. SRT1720 (a SIRT1 activator) was administered by oral gavage from day 0 to day 17 in both groups. Our data showed that activation of SIRT1 or PPARγ alleviated the abnormal blood glucose metabolism and lung tissue injury, downregulated expression of surfactant proteins (SP-B and SP-C), and decreased activation of the PI3K/AKT pathway induced by GDM and late preterm birth in neonatal rats. Moreover, an insulin resistance model was established by treating primary AT-II cells with insulin. Activation of SIRT1 reversed insulin-induced reduction in cell proliferation, glucose consumption, SP-B and SP-C expression, and the activity of the PI3K/AKT pathway and increase in cellular inflammation and apoptosis. Mechanistically, SIRT1 upregulated PPARγ expression via deacetylation of QKI5, an RNA binding protein that can stabilize its target mRNA molecules, and then activated the PI3K/AKT pathway. In conclusion, SIRT1 promotes the expression of PPARγ via upregulation of QKI5 and activates the PI3K/AKT pathway, thus mitigating NRDS caused by GDM and late preterm birth.
doi: 10.1080/15384101.2023.2297567
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: He J
      type: Person
      first name: Jinxiao
      last name: He
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 2
    item: Fan F
      type: Person
      first name: Fang
      last name: Fan
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 3
    item: Li J
      type: Person
      first name: Jingxian
      last name: Li
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 4
    item: Han Y
      type: Person
      first name: Yi
      last name: Han
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 5
    item: Song Y
      type: Person
      first name: Ye
      last name: Song
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 6
    item: Zhang R
      type: Person
      first name: Rong
      last name: Zhang
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 7
    item: Xu Y
      type: Person
      first name: Yang
      last name: Xu
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 8
    item: Wu H
      type: Person
      first name: Huajie
      last name: Wu
      member of: Department of Pediatrics, The First Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
  slot:
    index: 9
    item: Fan R
      type: Person
      first name: Rui
      last name: Fan
created: 2023-12-26T06:41
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-26T05:43
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2449
ending page: 2466
has place of publication: United States
has primary subject term: D016640Q000235Q000378
has primary subject term: D007333Q000235
has primary subject term: D047928
has primary subject term: D012128
has subject term: D000818
has subject term: D005260
has subject term: D011247
has subject term: D051381
has subject term: D007328
has subject term: D008070
has subject term: D019869Q000378
has subject term: D047495Q000378
has subject term: D051057Q000378
has subject term: D015398
has subject term: D056564Q000378
source: Cell Cycle. 2023-11;22(21-22):2449-2466.
volume: 22

High-density lipoprotein protects vascular endothelial cells from indoxyl sulfate insults through its antioxidant ability.
pmid: 38129288
abstract: Chronic kidney disease (CKD) patients have a high risk of cardiovascular disease. Indoxyl sulfate (IS) is a uremic toxin that has been shown to inhibit nitric oxide production and cause cell senescence by inducing oxidative stress. High-density lipoprotein (HDL) has a protective effect on the cardiovascular system; however, its impacts on IS-damaged endothelial cells are still unknown. This study aimed to explore the effects of exogenous supplement of HDL on vascular endothelial cells in a uremia-mimic environment. Tube formation, migration, adhesion, and senescence assays were used to evaluate the cell function of human aortic endothelial cells (HAECs). Reactive oxygen species generation was measured by using Amplex red assay. L-NAME and MCI186 were used as a nitric oxide synthase inhibitor and a free radical scavenger, respectively. HDL exerted anti-inflammatory and antioxidant effects via HIF-1α/HO-1 activation and IL-1β/TNF-α/IL-6 inhibition in IS-stimulated HAECs. HDL improved angiogenesis ability through upregulating Akt/eNOS/VEGF/SDF-1 in IS-stimulated HAECs. HDL decreased endothelial adhesiveness via downregulating VCAM-1 and ICAM-1 in IS-stimulated HAECs. Furthermore, HDL reduced cellular senescence via upregulating SIRT1 and downregulating p53 in IS-stimulated HAECs. Importantly, the above beneficial effects of HDL were mainly due to its antioxidant ability. In conclusion, HDL exerted a comprehensive protective effect on vascular endothelial cells against damage from IS through its antioxidant ability. The results of this study might provide a theoretical basis for potential HDL supplementation in CKD patients with endothelial damage.
doi: 10.1080/15384101.2023.2296184
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Chen C
      type: Person
      first name: Ching
      last name: Chen
      member of: Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  slot:
    index: 2
    item: Chang CC
      type: Person
      first name: Chia-Chi
      last name: Chang
      member of: Departments of Internal Medicine, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.
  slot:
    index: 3
    item: Lee IT
      type: Person
      first name: I-Ta
      last name: Lee
      member of: School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
  slot:
    index: 4
    item: Huang CY
      type: Person
      first name: Chun-Yao
      last name: Huang
      member of: Departments of Internal Medicine, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
  slot:
    index: 5
    item: Lin FY
      type: Person
      first name: Feng-Yen
      last name: Lin
      member of: Departments of Internal Medicine, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
  slot:
    index: 6
    item: Lin SJ
      type: Person
      first name: Shing-Jong
      last name: Lin
      member of: Departments of Internal Medicine, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
  slot:
    index: 7
    item: Chen JW
      type: Person
      first name: Jaw-Wen
      last name: Chen
      member of: Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.Departments of Internal Medicine, College of Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan.Department of Research, Taipei Medical University Hospital, Taipei, Taiwan.Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  slot:
    index: 8
    item: Chang TT
      type: Person
      first name: Ting-Ting
      last name: Chang
      member of: Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
created: 2023-12-22T00:42
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-21T22:02
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2409
ending page: 2423
has place of publication: United States
has primary subject term: D000975Q000494Q000378
has primary subject term: D051436Q000378
has subject term: D006801
has subject term: D008075Q000494Q000378
has subject term: D007200Q000494
has subject term: D042783Q000378
source: Cell Cycle. 2023-11;22(21-22):2409-2423.
volume: 22

CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
pmid: 38146657
abstract: Endometriosis is a benign high prevalent disease exhibiting malignant features. However, the underlying pathogenesis and key molecules of endometriosis remain unclear. By integrating and analysis of existing expression profile datasets, we identified coxsackie and adenovirus receptor (CXADR), as a novel key gene in endometriosis. Based on the results of immunohistochemistry (IHC), we confirmed significant down-regulation of CXADR in ectopic endometrial tissues obtained from women with endometriosis compared with healthy controls. Further in vitro investigation indicated that CXADR regulated the stability and function of the phosphatases and AKT inhibitors PHLPP2 (pleckstrin homology domain and leucine-rich repeat protein phosphatase 2) and PTEN (phosphatase and tensin homolog). Loss of CXADR led to phosphorylation of AKT and glycogen synthase kinase-3β (GSK-3β), which resulted in stabilization of an epithelial-mesenchymal transition (EMT) factor, SNAIL1 (snail family transcriptional repressor 1). Therefore, EMT processs was induced, and the proliferation, migration and invasion of Ishikawa cells were enhanced. Over-expression of CXADR showed opposite effects. These findings suggest a previously undefined role of AKT/GSK-3β signaling axis in regulating EMT and reveal the involvement of a CXADR-induced EMT, in pathogenic progression of endometriosis.
doi: 10.1080/15384101.2023.2296242
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Tan HJ
      type: Person
      first name: Hang-Jing
      last name: Tan
      member of: Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.Center for Reproductive Health, and System Biology, Data Sciences, School of Basic Medical Science, Central South University, Changsha, China.
  slot:
    index: 2
    item: Deng ZH
      type: Person
      first name: Zi-Heng
      last name: Deng
      member of: Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.Center for Reproductive Health, and System Biology, Data Sciences, School of Basic Medical Science, Central South University, Changsha, China.
  slot:
    index: 3
    item: Zhang C
      type: Person
      first name: Chun
      last name: Zhang
      member of: Department of Gynaecology and Obstetrics, Xiangya Hospital, Central South University, Changsha, China.
  slot:
    index: 4
    item: Deng HW
      type: Person
      first name: Hong-Wen
      last name: Deng
      member of: Center of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
  slot:
    index: 5
    item: Xiao HM
      type: Person
      first name: Hong-Mei
      last name: Xiao
      member of: Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.Center for Reproductive Health, and System Biology, Data Sciences, School of Basic Medical Science, Central South University, Changsha, China.
created: 2023-12-26T06:41
date last updated: 2025-01-20
issued: 2023-11
dp: 2023 11
created: 2023-12-26T05:29
e ISSN: 1551-4005
has issn l: 1551-4005
issue: 21-22
has NLM journal title abbreviation: Cell Cycle
publication name: Cell cycle (Georgetown, Tex.)
language: eng
has national library of medicine journal id: 101137841
derived from: NLM
starting page: 2436
ending page: 2448
has place of publication: United States
has primary subject term: D004715Q000235
has primary subject term: D051057Q000378
has subject term: D005260
has subject term: D006801
has subject term: D015815
has subject term: D045744
has subject term: D002465
has subject term: D058750
has subject term: http://id.nlm.nih.gov/mesh/D000071679
has subject term: D010749Q000494
has subject term: D010744
has subject term: D000071250Q000235Q000378
source: Cell Cycle. 2023-11;22(21-22):2436-2448.
volume: 22

Mitofusin-2 Regulates Platelet Mitochondria and Function.
pmid: 38156445
abstract: Single-nucleotide polymorphisms linked with the rs1474868 T allele (MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are associated with reduced platelet MFN2 RNA expression and platelet counts. This study investigates the impact of MFN2 on megakaryocyte and platelet biology.Mice with megakaryocyte/platelet deletion of Mfn2 (Mfn2-/- [Mfn2 conditional knockout]) were generated using Pf4-Cre crossed with floxed Mfn2 mice. Human megakaryocytes were generated from cord blood and platelets isolated from healthy subjects genotyped for rs1474868. Ex vivo approaches assessed mitochondrial morphology, function, and platelet activation responses. In vivo measurements included endogenous/transfused platelet life span, tail bleed time, transient middle cerebral artery occlusion, and pulmonary vascular permeability/hemorrhage following lipopolysaccharide-induced acute lung injury.Mitochondria was more fragmented in megakaryocytes derived from Mfn2-/- mice and from human cord blood with MFN2 T/T genotype compared with control megakaryocytes. Human resting platelets of MFN2 T/T genotype had reduced MFN2 protein, diminished mitochondrial membrane potential, and an increased rate of phosphatidylserine exposure during ex vivo culture. Platelet counts and platelet life span were reduced in Mfn2-/- mice accompanied by an increased rate of phosphatidylserine exposure in resting platelets, especially aged platelets, during ex vivo culture. Mfn2-/- also decreased platelet mitochondrial membrane potential (basal) and activated mitochondrial oxygen consumption rate, reactive oxygen species generation, calcium flux, platelet-neutrophil aggregate formation, and phosphatidylserine exposure following dual agonist activation. Ultimately, Mfn2-/- mice showed prolonged tail bleed times, decreased ischemic stroke infarct size after cerebral ischemia-reperfusion, and exacerbated pulmonary inflammatory hemorrhage following lipopolysaccharide-induced acute lung injury. Analy[cell cut: 2375 characters, first 2000 kept]
doi: 10.1161/CIRCRESAHA.123.322914
creator: OrderedList
  length: 28
  slot:
    index: 1
    item: Jacob S
      type: Person
      first name: Shancy
      last name: Jacob
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 2
    item: Kosaka Y
      type: Person
      first name: Yasuhiro
      last name: Kosaka
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 3
    item: Bhatlekar S
      type: Person
      first name: Seema
      last name: Bhatlekar
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 4
    item: Denorme F
      type: Person
      first name: Frederik
      last name: Denorme
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 5
    item: Benzon H
      type: Person
      first name: Haley
      last name: Benzon
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 6
    item: Moody A
      type: Person
      first name: Alexandra
      last name: Moody
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 7
    item: Moody V
      type: Person
      first name: Victoria
      last name: Moody
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 8
    item: Tugolukova EA
      type: Person
      first name: Emilia A
      last name: Tugolukova
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 9
    item: Hull G
      type: Person
      first name: Grayson
      last name: Hull
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 10
    item: Kishimoto N
      type: Person
      first name: Nina
      last name: Kishimoto
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 11
    item: Manne BK
      type: Person
      first name: Bhanu K
      last name: Manne
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 12
    item: Guo L
      type: Person
      first name: Li
      last name: Guo
      member of: Division of Hematology and Oncology, Bloodworks Northwest Research Institute, Seattle, WA (L.G.).
  slot:
    index: 13
    item: Souvenir R
      type: Person
      first name: Rhonda
      last name: Souvenir
      member of: David Geffen School of Medicine and UCLA Health (R.S., E.D.A.), Los Angeles, CA.
  slot:
    index: 14
    item: Seliger BJ
      type: Person
      first name: Brayden J
      last name: Seliger
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 15
    item: Eustes AS
      type: Person
      first name: Alicia S
      last name: Eustes
      member of: University of Iowa (A.S.E.), Iowa City, IA.
  slot:
    index: 16
    item: Hoerger K
      type: Person
      first name: Kelly
      last name: Hoerger
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 17
    item: Tolley ND
      type: Person
      first name: Neal D
      last name: Tolley
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 18
    item: Fatahian AN
      type: Person
      first name: Amir N
      last name: Fatahian
      member of: Department of Nutrition and Integrative Physiology (A.N.F., S. Boudina), University of Utah, Salt Lake City, UT.
  slot:
    index: 19
    item: Boudina S
      type: Person
      first name: Sihem
      last name: Boudina
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.Department of Nutrition and Integrative Physiology (A.N.F., S. Boudina), University of Utah, Salt Lake City, UT.
  slot:
    index: 20
    item: Christiani DC
      type: Person
      first name: David C
      last name: Christiani
      member of: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA (D.C.C.).Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA (D.C.C.).
  slot:
    index: 21
    item: Wei Y
      type: Person
      first name: Yongyue
      last name: Wei
      member of: Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China (Y.W.).Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China (Y.W.).
  slot:
    index: 22
    item: Ju C
      type: Person
      first name: Can
      last name: Ju
      member of: Department of Biostatistics, School of Public Health, Nanjing Medical University, Jiangsu, China (C.J.).
  slot:
    index: 23
    item: Campbell RA
      type: Person
      first name: Robert A
      last name: Campbell
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.Division of Hematology and Hematologic Malignancies (R.A.C., M.T.R., P.F.B), University of Utah, Salt Lake City, UT.Department of Internal Medicine (P.F.B., J.W.R, M.T.R., R.A.C.), University of Utah, Salt Lake City, UT.Department of Pathology (R.A.C., M.T.R.), University of Utah, Salt Lake City, UT.
  slot:
    index: 24
    item: Rondina MT
      type: Person
      first name: Matthew T
      last name: Rondina
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.Division of Hematology and Hematologic Malignancies (R.A.C., M.T.R., P.F.B), University of Utah, Salt Lake City, UT.Department of Internal Medicine (P.F.B., J.W.R, M.T.R., R.A.C.), University of Utah, Salt Lake City, UT.Department of Pathology (R.A.C., M.T.R.), University of Utah, Salt Lake City, UT.The Geriatric Research Education and Clinical Center (GRECC), George E. Wahlen Department of Veterans Affairs Medical Center (VAMC), Salt Lake City, UT (M.T.R.).
  slot:
    index: 25
    item: Abel ED
      type: Person
      first name: E Dale
      last name: Abel
      member of: David Geffen School of Medicine and UCLA Health (R.S., E.D.A.), Los Angeles, CA.
  slot:
    index: 26
    item: Bray PF
      type: Person
      first name: Paul F
      last name: Bray
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.Division of Hematology and Hematologic Malignancies (R.A.C., M.T.R., P.F.B), University of Utah, Salt Lake City, UT.Department of Internal Medicine (P.F.B., J.W.R, M.T.R., R.A.C.), University of Utah, Salt Lake City, UT.
  slot:
    index: 27
    item: Weyrich AS
      type: Person
      first name: Andrew S
      last name: Weyrich
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.Oklahoma Medical Research Foundation (A.S.W.), Oklahoma City, OK.
  slot:
    index: 28
    item: Rowley JW
      type: Person
      first name: Jesse W
      last name: Rowley
      member of: Molecular Medicine Program, (S.J., Y.K., S. Bhatlekar, F.D., H.B., A.M., V.M., E.T., G.H., N.K., B.K.M., B.J.S., K.H., N.D.T., S. Boudina, R.A.C., M.T.R., P.F.B., A.S.W., J.W.R.), University of Utah, Salt Lake City, UT.Department of Internal Medicine (P.F.B., J.W.R, M.T.R., R.A.C.), University of Utah, Salt Lake City, UT.
created: 2023-12-29T06:43
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2023-12-29T05:29
e ISSN: 1524-4571
has issn l: 0009-7330
issue: 2
has NLM journal title abbreviation: Circ Res
publication name: Circulation research
language: eng
has national library of medicine journal id: 0047103
derived from: NLM
starting page: 143
ending page: 161
has place of publication: United States
has primary subject term: D055371Q000378
has primary subject term: D008070
has subject term: D000368
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D001792Q000378
has subject term: D006470Q000378
has subject term: D008928Q000378
has subject term: D010718Q000378
source: Circ Res. 2024-01-19;134(2):143-161.
volume: 134

Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.
pmid: 38134231
abstract: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project.We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES).Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups.Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.
rights: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
doi: 10.1002/alz.13602
creator: OrderedList
  length: 30
  slot:
    index: 1
    item: Su Y
      type: Person
      first name: Yi
      last name: Su
      member of: Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
  slot:
    index: 2
    item: Protas H
      type: Person
      first name: Hillary
      last name: Protas
      member of: Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
  slot:
    index: 3
    item: Luo J
      type: Person
      first name: Ji
      last name: Luo
      member of: Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
  slot:
    index: 4
    item: Chen K
      type: Person
      first name: Kewei
      last name: Chen
      member of: Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
  slot:
    index: 5
    item: Alosco ML
      type: Person
      first name: Michael L
      last name: Alosco
      member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  slot:
    index: 6
    item: Adler CH
      type: Person
      first name: Charles H
      last name: Adler
      member of: Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
  slot:
    index: 7
    item: Balcer LJ
      type: Person
      first name: Laura J
      last name: Balcer
      member of: Departments of Neurology, NYU Grossman School of Medicine, New York, New York, USA.Department of Population Health and Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 8
    item: Bernick C
      type: Person
      first name: Charles
      last name: Bernick
      member of: Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.Department of Neurology, University of Washington, Seattle, Washington, USA.
  slot:
    index: 9
    item: Au R
      type: Person
      first name: Rhoda
      last name: Au
      member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.Framingham Heart Study, Framingham, Massachusetts, USA.Slone Epidemiology Center; Departments of Anatomy & Neurobiology, Neurology, and Medicine, Department of Epidemiology, Boston University Chobanian & Avedisian School of Medicine; Boston University School of Public Health, Boston, Massachusetts, USA.
  slot:
    index: 10
    item: Banks SJ
      type: Person
      first name: Sarah J
      last name: Banks
      member of: Departments of Neuroscience and Psychiatry, University of California, San Diego, California, USA.
  slot:
    index: 11
    item: Barr WB
      type: Person
      first name: William B
      last name: Barr
      member of: Departments of Neurology, NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 12
    item: Coleman MJ
      type: Person
      first name: Michael J
      last name: Coleman
      member of: Departments of Psychiatry and Radiology, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 13
    item: Dodick DW
      type: Person
      first name: David W
      last name: Dodick
      member of: Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
  slot:
    index: 14
    item: Katz DI
      type: Person
      first name: Douglas I
      last name: Katz
      member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.Encompass Health Braintree Rehabilitation Hospital, Braintree, Massachusetts, USA.
  slot:
    index: 15
    item: Marek KL
      type: Person
      first name: Kenneth L
      last name: Marek
      member of: Institute for Neurodegenerative Disorders, Invicro, LLC, New Haven, Connecticut, USA.
  slot:
    index: 16
    item: McClean MD
      type: Person
      first name: Michael D
      last name: McClean
      member of: Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
  slot:
    index: 17
    item: McKee AC
      type: Person
      first name: Ann C
      last name: McKee
      member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.VA Boston Healthcare System, Boston, Massachusetts, USA.
  slot:
    index: 18
    item: Mez J
      type: Person
      first name: Jesse
      last name: Mez
      member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.Framingham Heart Study, Framingham, Massachusetts, USA.
  slot:
    index: 19
    item: Daneshvar DH
      type: Person
      first name: Daniel H
      last name: Daneshvar
      member of: Department of Physical Medicine & Rehabilitation, Massachusetts General Hospital, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  slot:
    index: 20
    item: Palmisano JN
      type: Person
      first name: Joseph N
      last name: Palmisano
      member of: Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Biostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, Boston, Massachusetts, USA.
  slot:
    index: 21
    item: Peskind ER
      type: Person
      first name: Elaine R
      last name: Peskind
      member of: Department of Psychiatry and Behavioral Sciences, VA Northwest Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System; University of Washington School of Medicine, Seattle, Washington, USA.
  slot:
    index: 22
    item: Turner RW
      type: Person
      first name: Robert W
      last name: Turner
      member of: Department of Clinical Research & Leadership, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, USA.
  slot:
    index: 23
    item: Wethe JV
      type: Person
      first name: Jennifer V
      last name: Wethe
      member of: Department of Psychiatry and Psychology, Mayo Clinic School of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
  slot:
    index: 24
    item: Rabinovici G
      type: Person
      first name: Gil
      last name: Rabinovici
      member of: Department of Neurology, University of California San Francisco, San Francisco, California, USA.
  slot:
    index: 25
    item: Johnson K
      type: Person
      first name: Keith
      last name: Johnson
      member of: Gordon Center for Medical Imaging, Mass General Research Institute, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 26
    item: Tripodis Y
      type: Person
      first name: Yorghos
      last name: Tripodis
      member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  slot:
    index: 27
    item: Cummings JL
      type: Person
      first name: Jeffrey L
      last name: Cummings
      member of: Department of Brain Health, Chambers-Grundy Center for Transformative Neuroscience, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
  slot:
    index: 28
    item: Shenton ME
      type: Person
      first name: Martha E
      last name: Shenton
      member of: Departments of Psychiatry and Radiology, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
creator: DIAGNOSE CTE Research Project Investigators
created: 2023-12-22T19:43
date last updated: 2025-01-20
issued: 2024-03
dp: 2024 03
created: 2023-12-22T14:05
e ISSN: 1552-5279
has issn l: 1552-5260
issue: 3
has NLM journal title abbreviation: Alzheimers Dement
publication name: Alzheimer's & dementia : the journal of the Alzheimer's Association
language: eng
has national library of medicine journal id: 101231978
derived from: NLM
starting page: 1827
ending page: 1838
has place of publication: United States
has primary subject term: D000070627Q000000981Q000473
has primary subject term: D005538Q000293
has primary subject term: D000070642Q000150
has primary subject term: D002243
has subject term: D008297
has subject term: D006801
has subject term: D008875
has subject term: D016875
has subject term: D049268
source: Alzheimers Dement. 2024-03;20(3):1827-1838.
volume: 20

Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change?
pmid: 38150745
abstract: The use of biomarkers for the early detection of Alzheimer's disease (AD) is crucial for developing potential therapeutic treatments. Positron Emission Tomography (PET) is a well-established tool used to detect β-amyloid (Aβ) plaques in the brain. Previous studies have shown that cross-sectional biomarkers can predict cognitive decline (Schindler et al.,2021). However, it is still unclear whether longitudinal Aβ-PET may have additional value for predicting time to cognitive impairment in AD. The current study aims to evaluate the ability of baseline- versus longitudinal rate of change in-11C-Pittsburgh compound B (PiB) Aβ-PET to predict cognitive decline. A cohort of 153 participants who previously underwent PiB-PET scans and comprehensive clinical assessments were used in this study. Our analyses revealed that baseline Aβ is significantly associated with the rate of change in cognitive composite scores, with cognition declining more rapidly when baseline PiB Aβ levels were higher. In contrast, no signification association was identified between the rate of change in PiB-PET Aβ and cognitive decline. Additionally, the ability of the rate of change in the PiB-PET measures to predict cognitive decline was significantly influenced by APOE ε4 carrier status. These results suggest that a single PiB-PET scan is sufficient to predict cognitive decline and that longitudinal measures of Aβ accumulation do not improve the prediction of cognitive decline once someone is amyloid positive.
rights: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S2213-1582(23)00242-5
doi: 10.1016/j.nicl.2023.103551
creator: OrderedList
  length: 18
  slot:
    index: 1
    item: Chen G
      type: Person
      first name: Gengsheng
      last name: Chen
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 2
    item: McKay NS
      type: Person
      first name: Nicole S
      last name: McKay
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 3
    item: Gordon BA
      type: Person
      first name: Brian A
      last name: Gordon
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 4
    item: Liu J
      type: Person
      first name: Jingxia
      last name: Liu
      member of: Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 5
    item: Joseph-Mathurin N
      type: Person
      first name: Nelly
      last name: Joseph-Mathurin
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 6
    item: Schindler SE
      type: Person
      first name: Suzanne E
      last name: Schindler
      member of: Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 7
    item: Hassenstab J
      type: Person
      first name: Jason
      last name: Hassenstab
      member of: Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 8
    item: Aschenbrenner AJ
      type: Person
      first name: Andrew J
      last name: Aschenbrenner
      member of: Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 9
    item: Wang Q
      type: Person
      first name: Qing
      last name: Wang
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 10
    item: Schultz SA
      type: Person
      first name: Stephanie A
      last name: Schultz
      member of: Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  slot:
    index: 11
    item: Su Y
      type: Person
      first name: Yi
      last name: Su
      member of: Banner Alzheimer's Institute, Phoenix, AZ, USA.
  slot:
    index: 12
    item: LaMontagne PJ
      type: Person
      first name: Pamela J
      last name: LaMontagne
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 13
    item: Keefe SJ
      type: Person
      first name: Sarah J
      last name: Keefe
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 14
    item: Massoumzadeh P
      type: Person
      first name: Parinaz
      last name: Massoumzadeh
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 15
    item: Cruchaga C
      type: Person
      first name: Carlos
      last name: Cruchaga
      member of: Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 16
    item: Xiong C
      type: Person
      first name: Chengjie
      last name: Xiong
      member of: Divison of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 17
    item: Morris JC
      type: Person
      first name: John C
      last name: Morris
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
  slot:
    index: 18
    item: Benzinger TLS
      type: Person
      first name: Tammie L S
      last name: Benzinger
      member of: Departments of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Electronic address: benzingert@wustl.edu.
created: 2023-12-28T00:42
date last updated: 2025-01-20
issued: 2024
dp: 2024
created: 2023-12-27T18:00
e ISSN: 2213-1582
has issn l: 2213-1582
has NLM journal title abbreviation: Neuroimage Clin
publication name: NeuroImage. Clinical
language: eng
has national library of medicine journal id: 101597070
derived from: NLM
pg: 103551
has place of publication: Netherlands
has primary subject term: D000544Q000000981
has primary subject term: D060825Q000000981
has subject term: D006801
has subject term: D003430
has subject term: D016229Q000378
has subject term: D000682Q000378
has subject term: D001921Q000000981Q000378
has subject term: D015415
has subject term: D049268Q000379
has subject term: D008137
source: Neuroimage Clin. 2024;41():103551.
volume: 41

Identification of Protein Targets of S-Nitroso-Coenzyme A-Mediated S-Nitrosation Using Chemoproteomics.
pmid: 38159293
abstract: S-Nitrosation is a cysteine post-translational modification fundamental to cellular signaling. This modification regulates protein function in numerous biological processes in the nervous, cardiovascular, and immune systems. Small molecule or protein nitrosothiols act as mediators of NO signaling by transferring the NO group (formally NO+) to a free thiol on a target protein through a transnitrosation reaction. The protein targets of specific transnitrosating agents and the extent and functional effects of S-nitrosation on these target proteins have been poorly characterized. S-nitroso-coenzyme A (CoA-SNO) was recently identified as a mediator of endogenous S-nitrosation. Here, we identified direct protein targets of CoA-SNO-mediated transnitrosation using a competitive chemical-proteomic approach that quantified the extent of modification on 789 cysteine residues in response to CoA-SNO. A subset of cysteines displayed high susceptibility to modification by CoA-SNO, including previously uncharacterized sites of S-nitrosation. We further validated and functionally characterized the functional effects of S-nitrosation on the protein targets phosphofructokinase (platelet type), ATP citrate synthase, and ornithine aminotransferase.
doi: 10.1021/acschembio.3c00654
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Falco JA
      type: Person
      first name: Julia A
      last name: Falco
      member of: Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
  slot:
    index: 2
    item: Wynia-Smith SL
      type: Person
      first name: Sarah L
      last name: Wynia-Smith
      member of: Department of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
  slot:
    index: 3
    item: McCoy J
      type: Person
      first name: James
      last name: McCoy
      member of: Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
  slot:
    index: 4
    item: Smith BC
      type: Person
      first name: Brian C
      last name: Smith
      member of: Department of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
  slot:
    index: 5
    item: Weerapana E
      type: Person
      first name: Eranthie
      last name: Weerapana
      member of: Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
created: 2024-1-2T11:42
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2023-12-30T14:03
e ISSN: 1554-8937
has issn l: 1554-8929
issue: 1
has NLM journal title abbreviation: ACS Chem Biol
publication name: ACS chemical biology
language: eng
has national library of medicine journal id: 101282906
derived from: NLM
starting page: 193
ending page: 207
has place of publication: United States
has primary subject term: D003545Q000737
has primary subject term: D026403Q000737Q000378
has primary subject term: D003065
has subject term: D015538
has subject term: D040901
has subject term: D011506Q000378
has subject term: D009569Q000378
source: ACS Chem Biol. 2024-01-19;19(1):193-207.
volume: 19

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
pmid: 38176414
abstract: A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames (ORFs). To address this question, we performed ribosome profiling of 32 medulloblastoma tissues and cell lines and observed widespread non-canonical ORF translation. We then developed a stepwise approach using multiple CRISPR-Cas9 screens to elucidate non-canonical ORFs and putative microproteins implicated in medulloblastoma cell survival. We determined that multiple lncRNA-ORFs and upstream ORFs (uORFs) exhibited selective functionality independent of main coding sequences. A microprotein encoded by one of these ORFs, ASNSD1-uORF or ASDURF, was upregulated, associated with MYC-family oncogenes, and promoted medulloblastoma cell survival through engagement with the prefoldin-like chaperone complex. Our findings underscore the fundamental importance of non-canonical ORF translation in medulloblastoma and provide a rationale to include these ORFs in future studies seeking to define new cancer targets.
rights: Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
has PII: S1097-2765(23)01022-5
doi: 10.1016/j.molcel.2023.12.003
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Hofman DA
      type: Person
      first name: Damon A
      last name: Hofman
      member of: Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  slot:
    index: 2
    item: Ruiz-Orera J
      type: Person
      first name: Jorge
      last name: Ruiz-Orera
      member of: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
  slot:
    index: 3
    item: Yannuzzi I
      type: Person
      first name: Ian
      last name: Yannuzzi
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 4
    item: Murugesan R
      type: Person
      first name: Rakesh
      last name: Murugesan
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 5
    item: Brown A
      type: Person
      first name: Adam
      last name: Brown
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 6
    item: Clauser KR
      type: Person
      first name: Karl R
      last name: Clauser
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 7
    item: Condurat AL
      type: Person
      first name: Alexandra L
      last name: Condurat
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  slot:
    index: 8
    item: van Dinter JT
      type: Person
      first name: Jip T
      last name: van Dinter
      member of: Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  slot:
    index: 9
    item: Engels SAG
      type: Person
      first name: Sem A G
      last name: Engels
      member of: Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  slot:
    index: 10
    item: Goodale A
      type: Person
      first name: Amy
      last name: Goodale
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 11
    item: van der Lugt J
      type: Person
      first name: Jasper
      last name: van der Lugt
      member of: Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  slot:
    index: 12
    item: Abid T
      type: Person
      first name: Tanaz
      last name: Abid
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 13
    item: Wang L
      type: Person
      first name: Li
      last name: Wang
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 14
    item: Zhou KN
      type: Person
      first name: Kevin N
      last name: Zhou
      member of: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  slot:
    index: 15
    item: Vogelzang J
      type: Person
      first name: Jayne
      last name: Vogelzang
      member of: Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.
  slot:
    index: 16
    item: Ligon KL
      type: Person
      first name: Keith L
      last name: Ligon
      member of: Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA; Department of Pathology, Boston Children's Hospital, Boston MA 02115, USA.
  slot:
    index: 17
    item: Phoenix TN
      type: Person
      first name: Timothy N
      last name: Phoenix
      member of: Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45229, USA.
  slot:
    index: 18
    item: Roth JA
      type: Person
      first name: Jennifer A
      last name: Roth
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 19
    item: Root DE
      type: Person
      first name: David E
      last name: Root
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  slot:
    index: 20
    item: Hubner N
      type: Person
      first name: Norbert
      last name: Hubner
      member of: Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany; German Centre for Cardiovascular Research, Partner Site Berlin, 13347 Berlin, Germany.
  slot:
    index: 21
    item: Golub TR
      type: Person
      first name: Todd R
      last name: Golub
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 22
    item: Bandopadhayay P
      type: Person
      first name: Pratiti
      last name: Bandopadhayay
      member of: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 23
    item: van Heesch S
      type: Person
      first name: Sebastiaan
      last name: van Heesch
      member of: Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands. Electronic address: s.vanheesch@prinsesmaximacentrum.nl.
  slot:
    index: 24
    item: Prensner JR
      type: Person
      first name: John R
      last name: Prensner
      member of: Department of Pediatrics, Division of Pediatric Hematology/Oncology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: prensner@umich.edu.
created: 2024-1-5T00:43
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2024-1-4T18:41
e ISSN: 1097-4164
has issn l: 1097-2765
issue: 2
has NLM journal title abbreviation: Mol Cell
publication name: Molecular cell
language: eng
has national library of medicine journal id: 9802571
derived from: NLM
starting page: 261
ending page: 276.e18
has place of publication: United States
has primary subject term: D008527Q000235
has primary subject term: D002528Q000235
has subject term: D006801
has subject term: D014176
has subject term: D016366Q000235
has subject term: D002470Q000235
source: Mol Cell. 2024-01-18;84(2):261-276.e18.
volume: 84

Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus.
pmid: 38176410
abstract: The very-low-density lipoprotein receptor (VLDLR) comprises eight LDLR type A (LA) domains and supports entry of distantly related alphaviruses, including Eastern equine encephalitis virus (EEEV) and Semliki Forest virus (SFV). Here, by resolving multiple cryo-electron microscopy structures of EEEV-VLDLR complexes and performing mutagenesis and functional studies, we show that EEEV uses multiple sites (E1/E2 cleft and E2 A domain) to engage more than one LA domain simultaneously. However, no single LA domain is necessary or sufficient to support efficient EEEV infection. Whereas all EEEV strains show conservation of two VLDLR-binding sites, the EEEV PE-6 strain and a few other EEE complex members feature a single amino acid substitution that enables binding of LA domains to an additional site on the E2 B domain. These structural and functional analyses informed the design of a minimal VLDLR decoy receptor that neutralizes EEEV infection and protects mice from lethal challenge.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S0092-8674(23)01318-1
doi: 10.1016/j.cell.2023.11.031
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Adams LJ
      type: Person
      first name: Lucas J
      last name: Adams
      member of: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  slot:
    index: 2
    item: Raju S
      type: Person
      first name: Saravanan
      last name: Raju
      member of: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  slot:
    index: 3
    item: Ma H
      type: Person
      first name: Hongming
      last name: Ma
      member of: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  slot:
    index: 4
    item: Gilliland T
      type: Person
      first name: Theron
      last name: Gilliland
      member of: The Center for Vaccine Research and Department of Immunology, The University of Pittsburgh, Pittsburgh, PA 15261, USA.
  slot:
    index: 5
    item: Reed DS
      type: Person
      first name: Douglas S
      last name: Reed
      member of: The Center for Vaccine Research and Department of Immunology, The University of Pittsburgh, Pittsburgh, PA 15261, USA.
  slot:
    index: 6
    item: Klimstra WB
      type: Person
      first name: William B
      last name: Klimstra
      member of: The Center for Vaccine Research and Department of Immunology, The University of Pittsburgh, Pittsburgh, PA 15261, USA.
  slot:
    index: 7
    item: Fremont DH
      type: Person
      first name: Daved H
      last name: Fremont
      member of: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: fremont@wustl.edu.
  slot:
    index: 8
    item: Diamond MS
      type: Person
      first name: Michael S
      last name: Diamond
      member of: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mdiamond@wustl.edu.
created: 2024-1-5T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-4T18:41
e ISSN: 1097-4172
has issn l: 0092-8674
issue: 2
has NLM journal title abbreviation: Cell
publication name: Cell
language: eng
has national library of medicine journal id: 0413066
derived from: NLM
starting page: 360
ending page: 374.e19
has place of publication: United States
has primary subject term: D020285
has primary subject term: D004663Q000502Q000648
has primary subject term: D004683Q000378
has primary subject term: D011973Q000648
has subject term: D000818
has subject term: D051379
has subject term: D000524Q000502
has subject term: D006736
has subject term: D011485
source: Cell. 2024-01-18;187(2):360-374.e19.
volume: 187

The influence of anisotropy on the clinical target volume of brain tumor patients.
pmid: 38157552
abstract: Objective.Current radiotherapy guidelines for glioma target volume definition recommend a uniform margin expansion from the gross tumor volume (GTV) to the clinical target volume (CTV), assuming uniform infiltration in the invaded brain tissue. However, glioma cells migrate preferentially along white matter tracts, suggesting that white matter directionality should be considered in an anisotropic CTV expansion. We investigate two models of anisotropic CTV expansion and evaluate their clinical feasibility.Approach.To incorporate white matter directionality into the CTV, a diffusion tensor imaging (DTI) atlas is used. The DTI atlas consists of water diffusion tensors that are first spatially transformed into local tumor resistance tensors, also known as metric tensors, and secondly fed to a CTV expansion algorithm to generate anisotropic CTVs. Two models of spatial transformation are considered in the first step. The first model assumes that tumor cells experience reduced resistance parallel to the white matter fibers. The second model assumes that the anisotropy of tumor cell resistance is proportional to the anisotropy observed in DTI, with an 'anisotropy weighting parameter' controlling the proportionality. The models are evaluated in a cohort of ten brain tumor patients.Main results.To evaluate the sensitivity of the model, a library of model-generated CTVs was computed by varying the resistance and anisotropy parameters. Our results indicate that the resistance coefficient had the most significant effect on the global shape of the CTV expansion by redistributing the target volume from potentially less involved gray matter to white matter tissue. In addition, the anisotropy weighting parameter proved useful in locally increasing CTV expansion in regions characterized by strong tissue directionality, such as near the corpus callosum.Significance.By incorporating anisotropy into the CTV expansion, this study is a step toward an interactive CTV definition that can as[cell cut: 2078 characters, first 2000 kept]
rights: © 2024 Institute of Physics and Engineering in Medicine.
doi: 10.1088/1361-6560/ad1997
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Buti G
      type: Person
      first name: Gregory
      last name: Buti
      member of: Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, Division of Radiation Biophysics, 100 Blossom St, Boston, MA 02114, United States of America.
  slot:
    index: 2
    item: Ajdari A
      type: Person
      first name: Ali
      last name: Ajdari
      member of: Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, Division of Radiation Biophysics, 100 Blossom St, Boston, MA 02114, United States of America.
  slot:
    index: 3
    item: Hochreuter K
      type: Person
      first name: Kim
      last name: Hochreuter
      member of: Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, Division of Radiation Biophysics, 100 Blossom St, Boston, MA 02114, United States of America.Aarhus University Hospital, Danish Centre for Particle Therapy, Palle Juul-Jensens Blvd. 99, DK-8200 Aarhus, Denmark.Aarhus University, Department of Clinical Medicine, Palle Juul-Jensens Blvd. 82, DK-8200 Aarhus, Denmark.
  slot:
    index: 4
    item: Shih H
      type: Person
      first name: Helen
      last name: Shih
      member of: Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, 100 Blossom St, Boston, MA 02114, United States of America.
  slot:
    index: 5
    item: Bridge CP
      type: Person
      first name: Christopher P
      last name: Bridge
      member of: Massachusetts General Hospital and Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth St, Charlestown, MA 02129, United States of America.
  slot:
    index: 6
    item: Sharp GC
      type: Person
      first name: Gregory C
      last name: Sharp
      member of: Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, Division of Radiation Biophysics, 100 Blossom St, Boston, MA 02114, United States of America.
  slot:
    index: 7
    item: Bortfeld T
      type: Person
      first name: Thomas
      last name: Bortfeld
      member of: Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, Division of Radiation Biophysics, 100 Blossom St, Boston, MA 02114, United States of America.
created: 2024-1-2T11:43
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 Jan 19
created: 2023-12-29T17:24
e ISSN: 1361-6560
has issn l: 0031-9155
issue: 3
has NLM journal title abbreviation: Phys Med Biol
publication name: Physics in medicine and biology
language: eng
has national library of medicine journal id: 0401220
derived from: NLM
has place of publication: England
has primary subject term: D001932Q000000981Q000532Q000473
has primary subject term: D005910Q000473
has subject term: D006801
has subject term: D056324Q000379
has subject term: D016880
has subject term: D011880Q000379
has subject term: D001921Q000473
source: Phys Med Biol. 2024-01-19;69(3):.
volume: 69

Enantioenriched Allylesters via a Copper-Catalyzed Diene Carboesterification with Alkyltrifluoroborates and Carboxylic Acids.
pmid: 38194284
abstract: The rapid synthesis of a range of enantioenriched allylic esters is enabled by a new 3-component catalytic enantioselective 1,2-carboesterification of readily available dienes with carboxylic acids and potassium alkyltrifluoroborates. The chiral copper catalyst, formed in situ from Cu(OTf)2 and (4S,4'S)-2,2'-(cyclopentane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole), is implicated in both the generation of alkyl radicals from the alkyltrifluoroborates as well as the enantioselective formation of C-O bonds. Potassium salts of primary and secondary alkyltrifluoroborates as well as several benzylic trifluoroborates, tert-butyltrifluoroborate, and phenyltrifluoroborate participate in the reaction. The regioselectivity and enantioselectivity are strongly impacted by variations in all of the reaction components, which in turn are thought to impact the C-O bond-forming reductive elimination from a [Cu(III)] intermediate.
doi: 10.1021/acs.joc.3c02461
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Kennedy-Ellis JJ
      type: Person
      first name: Jonathan J
      last name: Kennedy-Ellis
      member of: Chemistry Department, Natural Science Complex, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
  slot:
    index: 2
    item: Kelleher AD
      type: Person
      first name: Alexis D
      last name: Kelleher
      member of: Chemistry Department, Natural Science Complex, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
  slot:
    index: 3
    item: Sayeed JA
      type: Person
      first name: Jaffer A
      last name: Sayeed
      member of: Chemistry Department, Natural Science Complex, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
  slot:
    index: 4
    item: Burde AS
      type: Person
      first name: Ameya S
      last name: Burde
      member of: Chemistry Department, Natural Science Complex, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
  slot:
    index: 5
    item: Chemler SR
      type: Person
      first name: Sherry R
      last name: Chemler
      member of: Chemistry Department, Natural Science Complex, The State University of New York at Buffalo, Buffalo, New York 14260, United States.
created: 2024-1-9T13:45
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 Jan 19
created: 2024-1-9T12:03
e ISSN: 1520-6904
has issn l: 0022-3263
issue: 2
has NLM journal title abbreviation: J Org Chem
publication name: The Journal of organic chemistry
language: eng
has national library of medicine journal id: 2985193R
derived from: NLM
starting page: 1256
ending page: 1263
has place of publication: United States
source: J Org Chem. 2024-01-19;89(2):1256-1263.
volume: 89

Cytoneme signaling provides essential contributions to mammalian tissue patterning.
pmid: 38171360
abstract: During development, morphogens pattern tissues by instructing cell fate across long distances. Directly visualizing morphogen transport in situ has been inaccessible, so the molecular mechanisms ensuring successful morphogen delivery remain unclear. To tackle this longstanding problem, we developed a mouse model for compromised sonic hedgehog (SHH) morphogen delivery and discovered that endocytic recycling promotes SHH loading into signaling filopodia called cytonemes. We optimized methods to preserve in vivo cytonemes for advanced microscopy and show endogenous SHH localized to cytonemes in developing mouse neural tubes. Depletion of SHH from neural tube cytonemes alters neuronal cell fates and compromises neurodevelopment. Mutation of the filopodial motor myosin 10 (MYO10) reduces cytoneme length and density, which corrupts neuronal signaling activity of both SHH and WNT. Combined, these results demonstrate that cytoneme-based signal transport provides essential contributions to morphogen dispersion during mammalian tissue development and suggest MYO10 is a key regulator of cytoneme function.
rights: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
has PII: S0092-8674(23)01333-8
doi: 10.1016/j.cell.2023.12.003
creator: OrderedList
  length: 19
  slot:
    index: 1
    item: Hall ET
      type: Person
      first name: Eric T
      last name: Hall
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 2
    item: Dillard ME
      type: Person
      first name: Miriam E
      last name: Dillard
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 3
    item: Cleverdon ER
      type: Person
      first name: Elizabeth R
      last name: Cleverdon
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 4
    item: Zhang Y
      type: Person
      first name: Yan
      last name: Zhang
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 5
    item: Daly CA
      type: Person
      first name: Christina A
      last name: Daly
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 6
    item: Ansari SS
      type: Person
      first name: Shariq S
      last name: Ansari
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 7
    item: Wakefield R
      type: Person
      first name: Randall
      last name: Wakefield
      member of: Cellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 8
    item: Stewart DP
      type: Person
      first name: Daniel P
      last name: Stewart
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 9
    item: Pruett-Miller SM
      type: Person
      first name: Shondra M
      last name: Pruett-Miller
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 10
    item: Lavado A
      type: Person
      first name: Alfonso
      last name: Lavado
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Pediatric Neurological Disease Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 11
    item: Carisey AF
      type: Person
      first name: Alex F
      last name: Carisey
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 12
    item: Johnson A
      type: Person
      first name: Amanda
      last name: Johnson
      member of: Cellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 13
    item: Wang YD
      type: Person
      first name: Yong-Dong
      last name: Wang
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 14
    item: Selner E
      type: Person
      first name: Emma
      last name: Selner
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 15
    item: Tanes M
      type: Person
      first name: Michael
      last name: Tanes
      member of: Center for In Vivo Imaging and Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 16
    item: Ryu YS
      type: Person
      first name: Young Sang
      last name: Ryu
      member of: Center for In Vivo Imaging and Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 17
    item: Robinson CG
      type: Person
      first name: Camenzind G
      last name: Robinson
      member of: Cellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 18
    item: Steinberg J
      type: Person
      first name: Jeffrey
      last name: Steinberg
      member of: Center for In Vivo Imaging and Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  slot:
    index: 19
    item: Ogden SK
      type: Person
      first name: Stacey K
      last name: Ogden
      member of: Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: stacey.ogden@stjude.org.
created: 2024-1-4T11:43
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-3T18:41
e ISSN: 1097-4172
has issn l: 0092-8674
issue: 2
has NLM journal title abbreviation: Cell
publication name: Cell
language: eng
has national library of medicine journal id: 0413066
derived from: NLM
starting page: 276
ending page: 293.e23
has place of publication: United States
has primary subject term: D021961Q000378
has primary subject term: D009218Q000378
has primary subject term: D015398
has primary subject term: D054259Q000166Q000378
has subject term: D000818
has subject term: D051379
has subject term: D001692
has subject term: D053823Q000378
has subject term: D011554Q000378
source: Cell. 2024-01-18;187(2):276-293.e23.
volume: 187

Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling.
pmid: 38159292
abstract: The TAM family of receptor tyrosine kinases is implicated in multiple distinct oncogenic signaling pathways. However, to date, there are no FDA-approved small molecule inhibitors for the TAM kinases. Inhibitor design and screening rely on tools to study the kinase activity. Our goal was to address this gap by designing a set of synthetic peptide substrates for each of the TAM family members: Tyro3, Axl, and Mer. We used an in vitro phosphoproteomics workflow to determine the substrate profile of each TAM kinase and input the identified substrates into our data processing pipeline, KINATEST-ID, producing a position-specific scoring matrix for each target kinase and generating a list of candidate synthetic peptide substrates. We synthesized and characterized a set of those substrate candidates, systematically measuring their initial phosphorylation rate with each TAM kinase by LC-MS. We also used the multimer modeling function of AlphaFold2 (AF2) to predict peptide-kinase interactions at the active site for each of the novel candidate peptide sequences against each of the TAM family kinases and observed that, remarkably, every sequence for which it predicted a putative catalytically competent interaction was also demonstrated biochemically to be a substrate for one or more of the TAM kinases. This work shows that kinase substrate design can be achieved using a combination of preference motifs and structural modeling, and it provides the first demonstration of peptide-protein interaction modeling with AF2 for predicting the likelihood of constructive catalytic interactions.
doi: 10.1021/acschembio.3c00549
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Widstrom NE
      type: Person
      first name: Naomi E
      last name: Widstrom
      member of: Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 2
    item: Andrianov GV
      type: Person
      first name: Grigorii V
      last name: Andrianov
      member of: Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.
  slot:
    index: 3
    item: Heier JL
      type: Person
      first name: Jason L
      last name: Heier
      member of: Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 4
    item: Heier C
      type: Person
      first name: Celina
      last name: Heier
      member of: Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States.
  slot:
    index: 5
    item: Karanicolas J
      type: Person
      first name: John
      last name: Karanicolas
      member of: Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.
  slot:
    index: 6
    item: Parker LL
      type: Person
      first name: Laurie L
      last name: Parker
      member of: Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States.
created: 2024-1-2T11:43
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2023-12-30T14:03
e ISSN: 1554-8937
has issn l: 1554-8929
issue: 1
has NLM journal title abbreviation: ACS Chem Biol
publication name: ACS chemical biology
language: eng
has national library of medicine journal id: 101282906
derived from: NLM
starting page: 117
ending page: 128
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000094963
has primary subject term: D011518Q000378
has subject term: D005668
has subject term: D020794
has subject term: D010455
source: ACS Chem Biol. 2024-01-19;19(1):117-128.
volume: 19

A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design.
pmid: 38181787
abstract: Cells self-organize molecules in space and time to generate complex behaviors, but we lack synthetic strategies for engineering spatiotemporal signaling. We present a programmable reaction-diffusion platform for designing protein oscillations, patterns, and circuits in mammalian cells using two bacterial proteins, MinD and MinE (MinDE). MinDE circuits act like single-cell radios, emitting frequency-barcoded fluorescence signals that can be spectrally isolated and analyzed using digital signal processing tools. We define how to genetically program these signals and connect their spatiotemporal dynamics to cell biology using engineerable protein-protein interactions. This enabled us to construct sensitive reporter circuits that broadcast endogenous cell signaling dynamics on a frequency-barcoded imaging channel and to build control signal circuits that synthetically pattern activities in the cell, such as protein condensate assembly and actin filamentation. Our work establishes a paradigm for visualizing, probing, and engineering cellular activities at length and timescales critical for biological function.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S0092-8674(23)01339-9
doi: 10.1016/j.cell.2023.12.007
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Rajasekaran R
      type: Person
      first name: Rohith
      last name: Rajasekaran
      member of: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Integrated Program in Biochemistry Graduate Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
  slot:
    index: 2
    item: Chang CC
      type: Person
      first name: Chih-Chia
      last name: Chang
      member of: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Biophysics Graduate Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
  slot:
    index: 3
    item: Weix EWZ
      type: Person
      first name: Elliott W Z
      last name: Weix
      member of: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
  slot:
    index: 4
    item: Galateo TM
      type: Person
      first name: Thomas M
      last name: Galateo
      member of: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
  slot:
    index: 5
    item: Coyle SM
      type: Person
      first name: Scott M
      last name: Coyle
      member of: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: smcoyle@wisc.edu.
created: 2024-1-6T10:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-5T18:46
e ISSN: 1097-4172
has issn l: 0092-8674
issue: 2
has NLM journal title abbreviation: Cell
publication name: Cell
language: eng
has national library of medicine journal id: 0413066
derived from: NLM
starting page: 345
ending page: 359.e16
has place of publication: United States
has primary subject term: D001426
has primary subject term: D015398
has primary subject term: D005057Q000378
has subject term: D000818
has subject term: D008322
has subject term: D058615Q000379
source: Cell. 2024-01-18;187(2):345-359.e16.
volume: 187

Continuous Fluorescence Assay for In Vitro Translation Compatible with Noncanonical Amino Acids.
pmid: 38194520
abstract: The tolerance of the translation apparatus toward noncanonical amino acids (ncAAs) has enabled the creation of diverse natural-product-like peptide libraries using mRNA display for use in drug discovery. Typical experiments testing for ribosomal ncAA incorporation involve radioactive end point assays to measure yield alongside mass spectrometry experiments to validate incorporation. These end point assays require significant postexperimental manipulation for analysis and prevent higher throughput analysis and optimization experiments. Continuous assays for in vitro translation involve the synthesis of fluorescent proteins which require the full complement of canonical AAs for function and are therefore of limited utility for testing of ncAAs. Here, we describe a new, continuous fluorescence assay for in vitro translation based on detection of a short peptide tag using an affinity clamp protein, which exhibits changes in its fluorescent properties upon binding. Using this assay in a 384-well format, we were able to validate the incorporation of a variety of ncAAs and also quickly test for the codon reading specificities of a variety of Escherichia coli tRNAs. This assay enables rapid assessment of ncAAs and optimization of translation components and is therefore expected to advance the engineering of the translation apparatus for drug discovery and synthetic biology.
doi: 10.1021/acssynbio.3c00353
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kerestesy GN
      type: Person
      first name: Gianna N
      last name: Kerestesy
      member of: Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23220 Virginia, United States.Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, 23298-0037 Virginia, United States.
  slot:
    index: 2
    item: Dods KK
      type: Person
      first name: Kara K
      last name: Dods
      member of: Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23220 Virginia, United States.Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, 23298-0037 Virginia, United States.
  slot:
    index: 3
    item: McFeely CAL
      type: Person
      first name: Clinton A L
      last name: McFeely
      member of: Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23220 Virginia, United States.Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, 23298-0037 Virginia, United States.
  slot:
    index: 4
    item: Hartman MCT
      type: Person
      first name: Matthew C T
      last name: Hartman
      member of: Chemistry, Virginia Commonwealth University, 1001 W Main Street, Richmond, 23220 Virginia, United States.Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, 23298-0037 Virginia, United States.
created: 2024-1-9T18:41
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2024-1-9T16:01
e ISSN: 2161-5063
has issn l: 2161-5063
issue: 1
has NLM journal title abbreviation: ACS Synth Biol
publication name: ACS synthetic biology
language: eng
has national library of medicine journal id: 101575075
derived from: NLM
starting page: 119
ending page: 128
has place of publication: United States
has primary subject term: D000596Q000378
has primary subject term: D000604Q000378
has subject term: D015202Q000379
has subject term: D011506Q000378
has subject term: D010455Q000378
has subject term: D012343Q000235Q000378
has subject term: D004926Q000235Q000378
source: ACS Synth Biol. 2024-01-19;13(1):119-128.
volume: 13

Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA.
pmid: 38176419
abstract: Viral infection and the antiviral innate immune response are regulated by the RNA modification m6A. m6A directs nearly all aspects of RNA metabolism by recruiting RNA-binding proteins that mediate the fate of m6A-containing RNA. m6A controls the antiviral innate immune response in diverse ways, including shielding viral RNA from detection by antiviral sensors and influencing the expression of cellular mRNAs encoding antiviral signaling proteins, cytokines, and effector proteins. While m6A and the m6A machinery are important for the antiviral response, the precise mechanisms that determine how the m6A machinery selects specific viral or cellular RNA molecules for modification during infection are not fully understood. In this review, we highlight recent findings that shed light on how viral infection redirects the m6A machinery during the antiviral response. A better understanding of m6A targeting during viral infection could lead to new immunomodulatory and therapeutic strategies against viral infection.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S2451-9456(23)00434-8
doi: 10.1016/j.chembiol.2023.12.004
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Aufgebauer CJ
      type: Person
      first name: Caroline J
      last name: Aufgebauer
      member of: Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
  slot:
    index: 2
    item: Bland KM
      type: Person
      first name: Katherine M
      last name: Bland
      member of: Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
  slot:
    index: 3
    item: Horner SM
      type: Person
      first name: Stacy M
      last name: Horner
      member of: Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: stacy.horner@duke.edu.
created: 2024-1-5T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-4T18:41
e ISSN: 2451-9448
has issn l: 2451-9448
issue: 1
has NLM journal title abbreviation: Cell Chem Biol
publication name: Cell chemical biology
language: eng
has national library of medicine journal id: 101676030
derived from: NLM
starting page: 100
ending page: 109
has place of publication: United States
has primary subject term: D012313
has primary subject term: D014777
has subject term: D006801
has subject term: D011932
has subject term: D007113
has subject term: D012367Q000235
source: Cell Chem Biol. 2024-01-18;31(1):100-109.
volume: 31

Machine learning interpretable models of cell mechanics from protein images.
pmid: 38194965
abstract: Cellular form and function emerge from complex mechanochemical systems within the cytoplasm. Currently, no systematic strategy exists to infer large-scale physical properties of a cell from its molecular components. This is an obstacle to understanding processes such as cell adhesion and migration. Here, we develop a data-driven modeling pipeline to learn the mechanical behavior of adherent cells. We first train neural networks to predict cellular forces from images of cytoskeletal proteins. Strikingly, experimental images of a single focal adhesion (FA) protein, such as zyxin, are sufficient to predict forces and can generalize to unseen biological regimes. Using this observation, we develop two approaches-one constrained by physics and the other agnostic-to construct data-driven continuum models of cellular forces. Both reveal how cellular forces are encoded by two distinct length scales. Beyond adherent cell mechanics, our work serves as a case study for integrating neural networks into predictive models for cell biology.
rights: Copyright © 2023 Elsevier Inc. All rights reserved.
has PII: S0092-8674(23)01331-4
doi: 10.1016/j.cell.2023.11.041
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Schmitt MS
      type: Person
      first name: Matthew S
      last name: Schmitt
      member of: James Franck Institute, University of Chicago, Chicago, IL 60637, USA; Department of Physics, University of Chicago, Chicago, IL 60637, USA; Kadanoff Center for Theoretical Physics, University of Chicago, Chicago, IL 60637, USA.
  slot:
    index: 2
    item: Colen J
      type: Person
      first name: Jonathan
      last name: Colen
      member of: James Franck Institute, University of Chicago, Chicago, IL 60637, USA; Department of Physics, University of Chicago, Chicago, IL 60637, USA; Kadanoff Center for Theoretical Physics, University of Chicago, Chicago, IL 60637, USA.
  slot:
    index: 3
    item: Sala S
      type: Person
      first name: Stefano
      last name: Sala
      member of: Department of Cell & Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
  slot:
    index: 4
    item: Devany J
      type: Person
      first name: John
      last name: Devany
      member of: James Franck Institute, University of Chicago, Chicago, IL 60637, USA; Department of Physics, University of Chicago, Chicago, IL 60637, USA.
  slot:
    index: 5
    item: Seetharaman S
      type: Person
      first name: Shailaja
      last name: Seetharaman
      member of: James Franck Institute, University of Chicago, Chicago, IL 60637, USA; Department of Physics, University of Chicago, Chicago, IL 60637, USA.
  slot:
    index: 6
    item: Caillier A
      type: Person
      first name: Alexia
      last name: Caillier
      member of: Department of Cell & Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
  slot:
    index: 7
    item: Gardel ML
      type: Person
      first name: Margaret L
      last name: Gardel
      member of: James Franck Institute, University of Chicago, Chicago, IL 60637, USA; Department of Physics, University of Chicago, Chicago, IL 60637, USA. Electronic address: gardel@uchicago.edu.
  slot:
    index: 8
    item: Oakes PW
      type: Person
      first name: Patrick W
      last name: Oakes
      member of: Department of Cell & Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA. Electronic address: poakes@luc.edu.
  slot:
    index: 9
    item: Vitelli V
      type: Person
      first name: Vincenzo
      last name: Vitelli
      member of: James Franck Institute, University of Chicago, Chicago, IL 60637, USA; Department of Physics, University of Chicago, Chicago, IL 60637, USA; Kadanoff Center for Theoretical Physics, University of Chicago, Chicago, IL 60637, USA. Electronic address: vitelli@uchicago.edu.
created: 2024-1-10T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-9T18:41
e ISSN: 1097-4172
has issn l: 0092-8674
issue: 2
has NLM journal title abbreviation: Cell
publication name: Cell
language: eng
has national library of medicine journal id: 0413066
derived from: NLM
starting page: 481
ending page: 494.e24
has place of publication: United States
has primary subject term: D003598Q000378
has primary subject term: http://id.nlm.nih.gov/mesh/D000069550
has subject term: D002448
has subject term: D003593Q000378
has subject term: D022001Q000378
has subject term: D008954
source: Cell. 2024-01-18;187(2):481-494.e24.
volume: 187

Local and dynamic regulation of neuronal glycolysis in vivo.
pmid: 38198527
abstract: Energy metabolism supports neuronal function. While it is well established that changes in energy metabolism underpin brain plasticity and function, less is known about how individual neurons modulate their metabolic states to meet varying energy demands. This is because most approaches used to examine metabolism in living organisms lack the resolution to visualize energy metabolism within individual circuits, cells, or subcellular regions. Here, we adapted a biosensor for glycolysis, HYlight, for use in Caenorhabditis elegans to image dynamic changes in glycolysis within individual neurons and in vivo. We determined that neurons cell-autonomously perform glycolysis and modulate glycolytic states upon energy stress. By examining glycolysis in specific neurons, we documented a neuronal energy landscape comprising three general observations: 1) glycolytic states in neurons are diverse across individual cell types; 2) for a given condition, glycolytic states within individual neurons are reproducible across animals; and 3) for varying conditions of energy stress, glycolytic states are plastic and adapt to energy demands. Through genetic analyses, we uncovered roles for regulatory enzymes and mitochondrial localization in the cellular and subcellular dynamic regulation of glycolysis. Our study demonstrates the use of a single-cell glycolytic biosensor to examine how energy metabolism is distributed across cells and coupled to dynamic states of neuronal function and uncovers unique relationships between neuronal identities and metabolic landscapes in vivo.
doi: 10.1073/pnas.2314699121
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Wolfe AD
      type: Person
      first name: Aaron D
      last name: Wolfe
      member of: Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06536.Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536.
  slot:
    index: 2
    item: Koberstein JN
      type: Person
      first name: John N
      last name: Koberstein
      member of: Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
  slot:
    index: 3
    item: Smith CB
      type: Person
      first name: Chadwick B
      last name: Smith
      member of: Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
  slot:
    index: 4
    item: Stewart ML
      type: Person
      first name: Melissa L
      last name: Stewart
      member of: Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
  slot:
    index: 5
    item: Gonzalez IJ
      type: Person
      first name: Ian J
      last name: Gonzalez
      member of: Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06536.Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536.
  slot:
    index: 6
    item: Hammarlund M
      type: Person
      first name: Marc
      last name: Hammarlund
      member of: Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06536.Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536.
  slot:
    index: 7
    item: Hyman AA
      type: Person
      first name: Anthony A
      last name: Hyman
      member of: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
  slot:
    index: 8
    item: Stork PJS
      type: Person
      first name: Philip J S
      last name: Stork
      member of: Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
  slot:
    index: 9
    item: Goodman RH
      type: Person
      first name: Richard H
      last name: Goodman
      member of: Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06536.Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536.Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
  slot:
    index: 10
    item: Colón-Ramos DA
      type: Person
      first name: Daniel A
      last name: Colón-Ramos
      member of: Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06536.Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536.Wu Tsai Institute, Yale University, New Haven, CT 06510.
created: 2024-1-10T18:42
date last updated: 2025-01-20
issued: 2024-01-16
dp: 2024 Jan 16
created: 2024-1-10T13:43
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 3
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2314699121
has place of publication: United States
has primary subject term: D006019
has primary subject term: D009474
has subject term: D000818
has subject term: D004734
has subject term: D017173
has subject term: D009473
source: Proc Natl Acad Sci U S A. 2024-01-16;121(3):e2314699121.
volume: 121

Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.
pmid: 38235838
abstract: Pain, when treated inadequately, puts preterm infants at a greater risk of developing clinical and behavioural sequelae because of their immature pain system. Preterm infants in need of intensive care are repeatedly and persistently exposed to noxious stimuli, and this happens during a critical window of their brain development with peak rates of brain growth, exuberant synaptogenesis and the developmental regulation of specific receptor populations. Nearly two-thirds of infants born at less than 29 weeks' gestation require mechanical ventilation for some duration during the newborn period. These neonates are endotracheally intubated and require repeated endotracheal suctioning. Endotracheal suctioning is identified as one of the most frequent and most painful procedures in premature infants, causing moderate to severe pain. Even with improved nursing performance and standard procedures based on neonatal needs, endotracheal suctioning remains associated with mild pain.To evaluate the benefits and harms of non-pharmacological interventions for the prevention of pain during endotracheal suctioning in mechanically ventilated neonates. Non-pharmacological interventions were compared to no intervention, standard care or another non-pharmacological intervention.We conducted searches in June 2023 in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via PubMed, Embase, CINAHL and three trial registries. We searched the reference lists of related systematic reviews, and of studies selected for inclusion.We included randomised controlled trials (RCTs), quasi-RCTs and cluster-RCTs that included term and preterm neonates who were mechanically ventilated via endotracheal tube or via tracheostomy tube and required endotracheal suctioning performed by doctors, nurses, physiotherapists or other healthcare professionals.Our main outcome measures were validated composite pain scores (including a combination of behavioural, physiological and contextual indicators).[cell cut: 5222 characters, first 2000 kept]
rights: Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
doi: 10.1002/14651858.CD013353.pub2
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Pirlotte S
      type: Person
      first name: Sofie
      last name: Pirlotte
      member of: Neonatology, UZ Brussel, Jette, Belgium.
  slot:
    index: 2
    item: Beeckman K
      type: Person
      first name: Katrien
      last name: Beeckman
      member of: Midwifery Research, Education and Policymaking, Universiteit Antwerpen, Brussel, Belgium.
  slot:
    index: 3
    item: Ooms I
      type: Person
      first name: Isabel
      last name: Ooms
      member of: Physiotherapy and Neonatology, UZ Brussel, Jette, Belgium.
  slot:
    index: 4
    item: Cools F
      type: Person
      first name: Filip
      last name: Cools
      member of: Neonatology, UZ Brussel, Jette, Belgium.CEBAM, Belgian Centre for Evidence-Based Medicine, Leuven, Belgium.Vrije Universiteit Brussel, Brussels, Belgium.
created: 2024-1-18T12:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-18T08:28
e ISSN: 1469-493X
has issn l: 1361-6137
has NLM journal title abbreviation: Cochrane Database Syst Rev
publication name: The Cochrane database of systematic reviews
language: eng
has national library of medicine journal id: 100909747
derived from: NLM
pg: CD013353
has place of publication: England
has primary subject term: D007234
has primary subject term: D010146Q000209Q000517
has primary subject term: D012121Q000009
has subject term: D006801
has subject term: D007223
has subject term: D007231
has subject term: D002543
has subject term: D005865
source: Cochrane Database Syst Rev. 2024-01-18;1():CD013353.
volume: 1

The role of serum/glucocorticoid-regulated kinase 1 in brain function following cerebral ischemia.
pmid: 38235747
abstract: Cardiopulmonary arrest (CA) is a major cause of death/disability in the U.S. with poor prognosis and survival rates. Current therapeutic challenges are physiologically complex because they involve hypoperfusion (decreased cerebral blood flow), neuroinflammation, and mitochondrial dysfunction. We previously discovered novel serum/glucocorticoid-regulated kinase 1 (SGK1) is highly expressed in brain of neurons that are susceptible to ischemia (hippocampus and cortex). We inhibited SGK1 and utilized pharmacological (specific inhibitor, GSK650394) and neuron-specific genetic approaches (shRNA) in rodent models of CA to determine if SGK1 is responsible for hypoperfusion, neuroinflammation, mitochondrial dysfunctional, and neurological deficits after CA. Inhibition of SGK1 alleviated cortical hypoperfusion and neuroinflammation (via Iba1, GFAP, and cytokine array). Treatment with GSK650394 enhanced mitochondrial function (via Seahorse respirometry) in the hippocampus 3 and 7 days after CA. Neuronal injury (via MAP2, dMBP, and Golgi staining) in the hippocampus and cortex was observed 7 days after CA but ameliorated with SGK1-shRNA. Moreover, SGK1 mediated neuronal injury by regulating the Ndrg1-SOX10 axis. Finally, animals subjected to CA exhibited learning/memory, motor, and anxiety deficits after CA, whereas SGK1 inhibition via SGK1-shRNA improved neurocognitive function. The present study suggests the fundamental roles of SGK1 in brain circulation and neuronal survival/death in cerebral ischemia-related diseases.
doi: 10.1177/0271678X231224508
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Wu CY
      type: Person
      first name: Celeste Yin-Chieh
      last name: Wu
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 2
    item: Zhang Y
      type: Person
      first name: Yulan
      last name: Zhang
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 3
    item: Xu L
      type: Person
      first name: Li
      last name: Xu
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 4
    item: Huang Z
      type: Person
      first name: Zhihai
      last name: Huang
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 5
    item: Zou P
      type: Person
      first name: Peibin
      last name: Zou
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 6
    item: Clemons GA
      type: Person
      first name: Garrett A
      last name: Clemons
      member of: Department of Cellular Biology and Anatomy, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 7
    item: Li C
      type: Person
      first name: Chun
      last name: Li
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 8
    item: Citadin CT
      type: Person
      first name: Cristiane T
      last name: Citadin
      member of: Department of Cellular Biology and Anatomy, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 9
    item: Zhang Q
      type: Person
      first name: Quanguang
      last name: Zhang
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
  slot:
    index: 10
    item: Lee RH
      type: Person
      first name: Reggie Hui-Chao
      last name: Lee
      member of: Stroke Center for Research, Louisiana State University Health, Shreveport, LA, USA.Department of Neurology, Louisiana State University Health, Shreveport, LA, USA.
created: 2024-1-18T12:43
date last updated: 2025-01-20
issued: 2024-07
dp: 2024 Jul
created: 2024-1-18T08:22
e ISSN: 1559-7016
has issn l: 0271-678X
issue: 7
has NLM journal title abbreviation: J Cereb Blood Flow Metab
publication name: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
language: eng
has national library of medicine journal id: 8112566
derived from: NLM
starting page: 1145
ending page: 1162
has place of publication: United States
has primary subject term: D017874Q000378
has primary subject term: D017346Q000378Q000037Q000235
has primary subject term: D002545Q000378
has subject term: D000818
has subject term: D008297
has subject term: D051379
has subject term: D006323Q000150
has subject term: D001921Q000378
has subject term: D009474Q000378
has subject term: D051381
has subject term: D008928Q000378
has subject term: D006624Q000378
has subject term: D002560Q000502Q000187
has subject term: D004195
has subject term: D008810
has subject term: D001565
has subject term: D019086
source: J Cereb Blood Flow Metab. 2024-07;44(7):1145-1162.
volume: 44

Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states.
pmid: 38199037
abstract: RNA secondary structure plays essential roles in encoding RNA regulatory fate and function. Most RNAs populate ensembles of alternatively paired states and are continually unfolded and refolded by cellular processes. Measuring these structural ensembles and their contributions to cellular function has traditionally posed major challenges, but new methods and conceptual frameworks are beginning to fill this void. In this review, we provide a mechanism- and function-centric compendium of the roles of RNA secondary structural ensembles and minority states in regulating the RNA life cycle, from transcription to degradation. We further explore how dysregulation of RNA structural ensembles contributes to human disease and discuss the potential of drugging alternative RNA states to therapeutically modulate RNA activity. The emerging paradigm of RNA structural ensembles as central to RNA function provides a foundation for a deeper understanding of RNA biology and new therapeutic possibilities.
rights: Copyright © 2023 Elsevier Ltd. All rights reserved.
has PII: S2451-9456(23)00440-3
doi: 10.1016/j.chembiol.2023.12.010
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Bose R
      type: Person
      first name: Ritwika
      last name: Bose
      member of: Therapeutic Innovation Center (THINC), Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 2
    item: Saleem I
      type: Person
      first name: Irfana
      last name: Saleem
      member of: Therapeutic Innovation Center (THINC), Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.
  slot:
    index: 3
    item: Mustoe AM
      type: Person
      first name: Anthony M
      last name: Mustoe
      member of: Therapeutic Innovation Center (THINC), Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address: anthony.mustoe@bcm.edu.
created: 2024-1-11T00:41
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-10T19:50
e ISSN: 2451-9448
has issn l: 2451-9448
issue: 1
has NLM journal title abbreviation: Cell Chem Biol
publication name: Cell chemical biology
language: eng
has national library of medicine journal id: 101676030
derived from: NLM
starting page: 17
ending page: 35
has place of publication: United States
has primary subject term: D012313Q000235
has subject term: D006801
has subject term: D017433
source: Cell Chem Biol. 2024-01-18;31(1):17-35.
volume: 31

Transjugular intrahepatic portosystemic shunts for adults with hepatorenal syndrome.
pmid: 38235907
abstract: Hepatorenal syndrome is a condition that occurs in people with chronic liver disease (such as alcoholic hepatitis, advanced cirrhosis, or fulminant liver failure) and portal hypertension. The prognosis is dismal, often with a survival of weeks to months. Hepatorenal syndrome is characterised by the development of intense splanchnic vasodilation favouring ascites and hypotension leading to renal vasoconstriction and acute renal failure. Therefore, treatment attempts focus on improving arterial pressure through the use of vasopressors, paracentesis, and increasing renal perfusion pressure. Several authors have reported that the placement of transjugular intrahepatic portosystemic shunts (TIPS) may be a therapeutic option because it decreases portal pressure and improves arterial and renal pressures. However, the evidence is not clearly documented and TIPS may cause adverse events. Accordingly, it is necessary to evaluate the evidence of the benefits and harms of TIPS to assess its value in people with hepatorenal syndrome.To evaluate the benefits and harms of transjugular intrahepatic portosystemic shunts (TIPS) in adults with hepatorenal syndrome compared with sham, no intervention, conventional treatment, or other treatments.We used standard, extensive Cochrane search methods. The latest search date was 2 June 2023.We included only randomised clinical trials with a parallel-group design, which compared the TIPS placement with sham, no intervention, conventional therapy, or other therapies, in adults aged 18 years or older, regardless of sex or ethnicity, diagnosed with chronic liver disease and hepatorenal syndrome. We excluded trials of adults with kidney failure due to causes not related to hepatorenal syndrome, and we also excluded data from quasi-randomised, cross-over, and observational study designs as we did not design a separate search for such studies.We used standard Cochrane methods. Our primary outcomes were 1. all-cause mortality, 2. morbidity due to an[cell cut: 5859 characters, first 2000 kept]
rights: Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
doi: 10.1002/14651858.CD011039.pub2
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Gonzalez-Garay AG
      type: Person
      first name: Alejandro G
      last name: Gonzalez-Garay
      member of: Research Methodology Department, Instituto Nacional de Pediatría, Mexico City, Mexico.
  slot:
    index: 2
    item: Serralde-Zúñiga AE
      type: Person
      first name: Aurora E
      last name: Serralde-Zúñiga
      member of: Clinical Nutrition Service, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  slot:
    index: 3
    item: Velasco Hidalgo L
      type: Person
      first name: Liliana
      last name: Velasco Hidalgo
      member of: Pediatric Oncology Department, Instituto Nacional de Pediatría, Mexico City, Mexico.
  slot:
    index: 4
    item: Flores García NC
      type: Person
      first name: Nayelli Cointa
      last name: Flores García
      member of: Gastroenterology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  slot:
    index: 5
    item: Aguirre-Salgado MI
      type: Person
      first name: Ma Isabel
      last name: Aguirre-Salgado
      member of: Medical Library, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
created: 2024-1-18T12:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-18T08:30
e ISSN: 1469-493X
has issn l: 1361-6137
has NLM journal title abbreviation: Cochrane Database Syst Rev
publication name: The Cochrane database of systematic reviews
language: eng
has national library of medicine journal id: 100909747
derived from: NLM
pg: CD011039
has place of publication: England
has primary subject term: D001927Q000209
has primary subject term: D006530Q000209Q000601
has primary subject term: D010538Q000209
has primary subject term: D019168Q000009
has subject term: D000328
has subject term: D006801
has subject term: D000418
has subject term: D001201Q000209Q000601
has subject term: D011788
has subject term: D016032
source: Cochrane Database Syst Rev. 2024-01-18;1():CD011039.
volume: 1

Unaccompanied unstable housing among racially, ethnically, sexually, and gender diverse youth: Intersecting identities bearing the greatest burden.
pmid: 38236247
abstract: Disparities in youth homelessness by racial/ethnic, sexual, and gender identities are well documented, though this literature lacks specificity regarding intersectional social identities of youth who are most likely to experience homelessness. Population-based cross-sectional data on youth from the 2019 Minnesota Student Survey (N = 80,456) were used to examine the relationship between parent caring and intersections of minoritized identities that experience the highest prevalence of two distinct types of unaccompanied unstable housing with expanded categories of sexual and gender identities. Exhaustive chi-square automatic interaction detection models revealed that low parent caring was the most common predictor of unaccompanied homelessness and running away, but there was important variation among youth of color at the intersection of sexual and gender identities. The findings reveal a more complex story of disparities in unaccompanied unstable housing among youth with multiple marginalized social identities and highlight the need to create culturally informed prevention and intervention strategies for parents of LGBTQ+ (lesbian, gay, bisexual, transgender, queer, and questioning) youth of color. The implications for prevention and intervention among subgroups with the highest prevalence are discussed in the context of interlocking systems of power and oppression. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
has PII: 2024-44930-001
doi: 10.1037/ort0000725
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Houghtaling LM
      type: Person
      first name: Laura M
      last name: Houghtaling
      member of: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota Twin Cities.
  slot:
    index: 2
    item: Simon K
      type: Person
      first name: Kay
      last name: Simon
      member of: Department of Family Social Science, College of Education and Human Development, University of Minnesota Twin Cities.
  slot:
    index: 3
    item: Gower AL
      type: Person
      first name: Amy L
      last name: Gower
      member of: Division of General Pediatrics and Adolescent Health, Department of Pediatrics, University of Minnesota Twin Cities.
  slot:
    index: 4
    item: McCurdy A
      type: Person
      first name: Amy
      last name: McCurdy
      member of: Department of Human Development and Family Sciences, University of Texas at Austin.
  slot:
    index: 5
    item: Rider GN
      type: Person
      first name: G Nic
      last name: Rider
      member of: Department of Family Medicine and Community Health, Institute for Sexual and Gender Health, University of Minnesota Medical School.
  slot:
    index: 6
    item: Russell ST
      type: Person
      first name: Stephen T
      last name: Russell
      member of: Department of Human Development and Family Sciences, University of Texas at Austin.
  slot:
    index: 7
    item: Eisenberg ME
      type: Person
      first name: Marla E
      last name: Eisenberg
      member of: Division of General Pediatrics and Adolescent Health, Department of Pediatrics, University of Minnesota Twin Cities.
created: 2024-1-18T12:43
date last updated: 2025-01-20
issued: 2024
dp: 2024
created: 2024-1-18T11:05
e ISSN: 1939-0025
has issn l: 0002-9432
issue: 3
has NLM journal title abbreviation: Am J Orthopsychiatry
publication name: The American journal of orthopsychiatry
language: eng
has national library of medicine journal id: 0400640
derived from: NLM
starting page: 311
ending page: 321
has place of publication: United States
has primary subject term: D000072339Q000523Q000706
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D000293
has subject term: D003430
has subject term: D008910
has subject term: D018453Q000523Q000706
has subject term: D006798
has subject term: D005006Q000523Q000706
has subject term: D012933
has subject term: D055815
source: Am J Orthopsychiatry. 2024;94(3):311-321.
volume: 94

Olfaction and Mobility in Older Adults.
pmid: 38236595
abstract: Decreased mobility is a hallmark of aging. Olfactory dysfunction is common in older adults and may be associated with declines in mobility.To determine whether poor olfaction was associated with faster declines in mobility in older adults.This cohort study included 2500 participants from the Health, Aging, and Body Composition Study. Participants completed the Brief Smell Identification Test during the year 3 clinical visit (1999-2000) and were followed for up to 7 years. A data analysis was conducted between January and July 2023.Olfaction was defined as good (test score, 11-12), moderate (9-10), hyposmia (7-8), or anosmia (0-6).Mobility was measured using the 20-m usual and fast walking tests in clinical visit years 3 to 6, 8, and 10 and the 400-m fast walking test in years 4, 6, 8, and 10.The primary analyses included 2500 participants (1292 women [51.7%]; 1208 men [48.3%]; 960 Black [38.4%] and 1540 White [61.6%] individuals; mean [SD] age, 75.6 [2.8] years). Multivariate-adjusted analyses showed that poor olfaction was associated with slower walking speed at baseline and a faster decline over time. Taking the 20-m usual walking test as an example, compared with participants with good olfaction, the speed at baseline was 0.027 (95% CI, 0-0.053) m/s slower for those with hyposmia and 0.034 (95% CI, 0.005-0.062) m/s slower for those with anosmia. Longitudinally, the annual decline was 0.004 (95% CI, 0.002-0.007) m/s/year faster for those with hyposmia and 0.01 (95% CI, 0.007-0.013) m/s/year faster for those with anosmia. Similar results were obtained for the 20-m and 400-m fast walking tests. Further, compared with participants with good olfaction, the odds of being unable to do the 400-m test were 2.02 (95% CI, 1.17-3.48) times higher for those with anosmia at the year 8 visit and 2.73 (95% CI, 1.40-5.35) times higher at year 10. Multiple sensitivity and subgroup analyses supported the robustness and generalizability of the findings.The results of this cohort stu[cell cut: 2186 characters, first 2000 kept]
has PII: 2814085
doi: 10.1001/jamaoto.2023.4375
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Yuan Y
      type: Person
      first name: Yaqun
      last name: Yuan
      member of: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
  slot:
    index: 2
    item: Chamberlin KW
      type: Person
      first name: Keran W
      last name: Chamberlin
      member of: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
  slot:
    index: 3
    item: Li C
      type: Person
      first name: Chenxi
      last name: Li
      member of: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
  slot:
    index: 4
    item: Luo Z
      type: Person
      first name: Zhehui
      last name: Luo
      member of: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
  slot:
    index: 5
    item: Simonsick EM
      type: Person
      first name: Eleanor M
      last name: Simonsick
      member of: Laboratory of Epidemiology and Population Science, Intramural Research Program of the National Institutes of Health, National Institute on Aging, Bethesda, Maryland.
  slot:
    index: 6
    item: Kucharska-Newton A
      type: Person
      first name: Anna
      last name: Kucharska-Newton
      member of: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill.
  slot:
    index: 7
    item: Chen H
      type: Person
      first name: Honglei
      last name: Chen
      member of: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
created: 2024-1-18T12:43
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 03 01
created: 2024-1-18T11:42
e ISSN: 2168-619X
has issn l: 2168-6181
issue: 3
has NLM journal title abbreviation: JAMA Otolaryngol Head Neck Surg
publication name: JAMA otolaryngology-- head & neck surgery
language: eng
has national library of medicine journal id: 101589542
derived from: NLM
starting page: 201
ending page: 208
has place of publication: United States
has primary subject term: D012903
has primary subject term: D000857Q000175
has subject term: D008297
has subject term: D006801
has subject term: D005260
has subject term: D000368
has subject term: D015331
has subject term: http://id.nlm.nih.gov/mesh/D000086582
has subject term: D000375
has subject term: http://id.nlm.nih.gov/mesh/D000072797
source: JAMA Otolaryngol Head Neck Surg. 2024-03-01;150(3):201-208.
volume: 150

Long-Term Risk and Prediction of Progression in Primary Angle Closure Suspect.
pmid: 38236591
abstract: Identifying primary angle closure suspect (PACS) eyes at risk of angle closure is crucial for its management. However, the risk of progression and its prediction are still understudied in long-term longitudinal studies about PACS.To explore baseline predictors and develop prediction models for the 14-year risk of progression from PACS to primary angle closure (PAC).This cohort study involved participants from the Zhongshan Angle Closure Prevention trial who had untreated eyes with PACS. Baseline examinations included tonometry, ultrasound A-scan biometry, and anterior segment optical coherence tomography (AS-OCT) under both light and dark conditions. Primary angle closure was defined as peripheral anterior synechiae in 1 or more clock hours, intraocular pressure (IOP) greater than 24 mm Hg, or acute angle closure. Based on baseline covariates, logistic regression models were built to predict the risk of progression from PACS to PAC during 14 years of follow-up.The analysis included 377 eyes from 377 patients (mean [SD] patient age at baseline, 58.28 [4.71] years; 317 females [84%]). By the 14-year follow-up visit, 93 eyes (25%) had progressed from PACS to PAC. In multivariable models, higher IOP (odds ratio [OR], 1.14 [95% CI, 1.04-1.25] per 1-mm Hg increase), shallower central anterior chamber depth (ACD; OR, 0.81 [95% CI, 0.67-0.97] per 0.1-mm increase), and shallower limbal ACD (OR, 0.96 [95% CI, 0.93-0.99] per 0.01 increase in peripheral corneal thickness) at baseline were associated with an increased 14-year risk of progression from PACS to PAC. As for AS-OCT measurements, smaller light-room trabecular-iris space area (TISA) at 500 μm from the scleral spur (OR, 0.86 [95% CI, 0.77-0.96] per 0.01-mm2 increase), smaller light-room angle recess area (ARA) at 750 μm from the scleral spur (OR, 0.93 [95% CI, 0.88-0.98] per 0.01-mm2 increase), and smaller dark-room TISA at 500 μm (OR, 0.89 [95% CI, 0.80-0.98] per 0.01-mm2 increase) at baseline were identified as predic[cell cut: 2600 characters, first 2000 kept]
has PII: 2814222
doi: 10.1001/jamaophthalmol.2023.5286
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Yuan Y
      type: Person
      first name: Yixiong
      last name: Yuan
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 2
    item: Xiong R
      type: Person
      first name: Ruilin
      last name: Xiong
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 3
    item: Wang W
      type: Person
      first name: Wei
      last name: Wang
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China.
  slot:
    index: 4
    item: Xu BY
      type: Person
      first name: Benjamin Y
      last name: Xu
      member of: Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California.
  slot:
    index: 5
    item: Liao C
      type: Person
      first name: Chimei
      last name: Liao
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 6
    item: Yang S
      type: Person
      first name: Shaopeng
      last name: Yang
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 7
    item: Li C
      type: Person
      first name: Cong
      last name: Li
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 8
    item: Zhang J
      type: Person
      first name: Jian
      last name: Zhang
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 9
    item: Yin Q
      type: Person
      first name: Qiuxia
      last name: Yin
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 10
    item: Zheng Y
      type: Person
      first name: Yingfeng
      last name: Zheng
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  slot:
    index: 11
    item: Friedman DS
      type: Person
      first name: David S
      last name: Friedman
      member of: Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.
  slot:
    index: 12
    item: Foster PJ
      type: Person
      first name: Paul J
      last name: Foster
      member of: NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom.
  slot:
    index: 13
    item: He M
      type: Person
      first name: Mingguang
      last name: He
      member of: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.Experimental Ophthalmology, The Hong Kong Polytechnic University, Hong Kong, China.
created: 2024-1-18T12:42
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 Mar 01
created: 2024-1-18T11:42
e ISSN: 2168-6173
has issn l: 2168-6165
issue: 3
has NLM journal title abbreviation: JAMA Ophthalmol
publication name: JAMA ophthalmology
language: eng
has national library of medicine journal id: 101589539
derived from: NLM
starting page: 216
ending page: 223
has place of publication: United States
has primary subject term: D032801
has primary subject term: D015812Q000175Q000601
has subject term: D005260
has subject term: D006801
has subject term: D002675
has subject term: D015331
has subject term: D007498
has subject term: D007429
has subject term: D041623Q000379
source: JAMA Ophthalmol. 2024-03-01;142(3):216-223.
volume: 142

Chemical exposures and demographic associations in cutaneous T-cell lymphoma: a large single institution physician validated cohort study.
pmid: 38236413
abstract: Cutaneous T-cell lymphomas (CTCL) are a rare group of T-cell neoplasms which infiltrate the skin and can result in substantial morbidity and mortality. Risk factors for CTCL are still poorly understood though recent studies suggest chemical exposures may play a role in its development. To further characterize patient-centered risk factors for CTCL, especially compared with matched controls, we performed one of the largest prospective cohort survey studies to date to examine patient-reported exposures and health-related quality of life (HRQoL) in association with concurrent clinical disease characteristics. Patient demographics, lifestyle factors, and chemical exposures were collected via clinical data and surveys. Descriptive statistics, ANOVA, Chi-square tests and t tests were utilized to compare patient-reported exposures and HRQoL in patients with CTCL versus matched healthy controls (HC). Statistically significant differences were identified between patients and HC in terms of race (non-white race 22.4% in CTCL patients vs. 18.8% in HC, P = 0.01), and education level (high school or less 41.6% in CTCL patients vs. 14.3% in HC, P = 0.001), but not with Fitzpatrick skin type (P = 0.11) or smoking status (P = 0.28). Notably, 36.0% of the CTCL patients reported exposures to chemicals, a near threefold increased percentage when compared to HC (12.9%). Among various chemical exposures, 27.0% of the CTCL patients specifically reported industrial chemical exposure, a more than two-fold increased percentage when compared to HC (12.9%). Itch and pain were significantly associated with skin disease severity (as evaluated by CTCL-specific mSWAT score) in advanced stage disease (stages IIB-IVB) (r = 0.48 and 0.57, P < 0.05). Itch and body mass index (BMI) were weakly associated with skin disease severity in early-stage disease (stages IA-IIA) (r = 0.27 and 0.20, P < 0.05).
rights: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s00403-023-02799-9
doi: 10.1007/s00403-023-02799-9
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Ren Z
      type: Person
      first name: Ziyou
      last name: Ren
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 2
    item: Chrisman LP
      type: Person
      first name: Lauren P
      last name: Chrisman
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 3
    item: Pang Y
      type: Person
      first name: Yanzhen
      last name: Pang
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 4
    item: Nguyen M
      type: Person
      first name: Morgan
      last name: Nguyen
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 5
    item: Hooper MJ
      type: Person
      first name: Madeline J
      last name: Hooper
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 6
    item: LeWitt TM
      type: Person
      first name: Tessa M
      last name: LeWitt
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 7
    item: Veon FL
      type: Person
      first name: Francesca L
      last name: Veon
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 8
    item: Guitart J
      type: Person
      first name: Joan
      last name: Guitart
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  slot:
    index: 9
    item: Zhou XA
      type: Person
      first name: Xiaolong A
      last name: Zhou
      member of: Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. alan.zhou@northwestern.edu.
created: 2024-1-18T12:43
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 Jan 18
created: 2024-1-18T11:22
e ISSN: 1432-069X
has issn l: 0340-3696
issue: 2
has NLM journal title abbreviation: Arch Dermatol Res
publication name: Archives of dermatological research
language: eng
has national library of medicine journal id: 8000462
derived from: NLM
pg: 74
has place of publication: Germany
has primary subject term: D016410Q000453
has primary subject term: D010820
has primary subject term: D012878Q000453
has subject term: D006801
has subject term: D015331
has subject term: D011446
has subject term: D011788
has subject term: D011537
source: Arch Dermatol Res. 2024-01-18;316(2):74.
volume: 316

Out-of-Pocket Costs and Outpatient Visits Among Patients With Cancer in High-Deductible Health Plans.
pmid: 38236593
abstract: High-deductible health plans (HDHPs) have grown rapidly and may adversely affect access to comprehensive cancer care.To evaluate the association of HDHPs with out-of-pocket medical costs and outpatient physician visits among patients with cancer.Using 2003 to 2017 data from the deidentified Optum Clinformatics Data Mart database from individuals with employer-sponsored health coverage, adults aged 18 to 64 years with cancer who were enrolled in low-deductible (≤$500 annually) health plans during a baseline year were identified. Patients whose employers then mandated a switch to an HDHP (≥$1000 annual deductible) were assigned to the HDHP group, while contemporaneous individuals with cancer at baseline who had no option but to continue enrollment in low-deductible plans were assigned to the control group. The 2 groups were matched on demographic variables (age, sex, race and ethnicity, US Census region, rural vs urban, and neighborhood poverty level), cancer type, morbidity score, number of baseline physician visits by specialty type, baseline out-of-pocket costs, and employer characteristics. These cohorts were followed up for up to 3 years after the baseline year. Data were analyzed from July 2021 to December 2022.Employer-mandated HDHP enrollment.Out-of-pocket medical expenditures and outpatient visits to primary care physicians, cancer specialists, and noncancer specialists.After matching, the sample included 45 708 patients with cancer (2703 patients in the HDHP group and 43 005 matched individuals in the control group); mean (SD) age in the HDHP and control groups was 52.9 (9.3) years and 52.9 (2.3) years, respectively, with 58.5% females in both groups. The matching procedure yielded variable weights for each individual in the control group, resulting in a weighted control group sample of 2703 patients. Patients with cancer who were switched to HDHPs experienced an increase in annual out-of-pocket medical expenditures of 68.1% (95% CI, 51.0%-85.3%; absolute in[cell cut: 2867 characters, first 2000 kept]
has PII: 2813943
doi: 10.1001/jamaoncol.2023.6052
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Trad NK
      type: Person
      first name: Nicolas K
      last name: Trad
      member of: Department of Medicine, Massachusetts General Hospital, Boston.
  slot:
    index: 2
    item: Zhang F
      type: Person
      first name: Fang
      last name: Zhang
      member of: Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
  slot:
    index: 3
    item: Wharam JF
      type: Person
      first name: James Franklin
      last name: Wharam
      member of: Department of Medicine, Duke University, Durham, North Carolina.Duke-Margolis Center for Health Policy, Durham, North Carolina.
created: 2024-1-18T12:42
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 Mar 01
created: 2024-1-18T11:42
e ISSN: 2374-2445
has issn l: 2374-2437
issue: 3
has NLM journal title abbreviation: JAMA Oncol
publication name: JAMA oncology
language: eng
has national library of medicine journal id: 101652861
derived from: NLM
starting page: 390
ending page: 394
has place of publication: United States
has primary subject term: D005102
has primary subject term: D009369Q000628
has subject term: D000328
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D015331
has subject term: D003669
has subject term: D010045
source: JAMA Oncol. 2024-03-01;10(3):390-394.
volume: 10

Intra-Anterior Chamber Injection of Ranibizumab in Advanced Pediatric Vitreoretinal Diseases.
pmid: 38236592
abstract: Anti-vascular endothelial growth factor (VEGF) treatment through intravitreal or subretinal administrations has been proven effective for VEGF-driven pediatric vitreoretinal diseases but are not feasible for advanced cases, such as shallow traction retinal detachments or peripheral circumferential retinal detachments which adhere to the lens. Intra-anterior chamber injection (IAcI) of anti-VEGF may be a viable alternative in such cases but needs evaluation.To investigate the effects and safety of IAcI of anti-VEGF to treat VEGF-driven pediatric vitreoretinal diseases.This was a retrospective observational case series study conducted at Xinhua Hospital, affiliated with Shanghai Jiao Tong University School of Medicine in China. The study included 14 eyes of 13 children diagnosed with vitreoretinal disease exhibiting elevated vascular activity between January and August 2023.IAcI with ranibizumab.Retinal vascular abnormalities, vitreous hemorrhage resolution, and complications 1 month and 3 months after injection.Of 13 patients included in this study, 12 were male. The mean age was 4.6 years (range, 1 month to 9 years). Six patients were diagnosed with familial exudative vitreoretinopathy, 4 with morning glory syndrome, 1 with retinopathy of prematurity, and 2 with chronic retinal detachments of unknown causes. At 1-month postoperative follow-up, vascular activity had decreased in 14 of 14 eyes. At 3-month follow-up, vascular activity had resolved in 7 of 14 eyes, persisted in 6 of 14 eyes, and reactivated in 1 of 14 eyes. On final observation, no complications were reported.These findings support the possibility of treatment using IAcI with ranibizumab to decrease retinal vascular abnormalities in familial exudative vitreoretinopathy or retinopathy of prematurity or related conditions, but further studies are needed to understand more precise benefits and risks. This approach might be considered in cases where intravitreal or subretinal injection are not feasible, rec[cell cut: 2100 characters, first 2000 kept]
has PII: 2814220
doi: 10.1001/jamaophthalmol.2023.6198
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Zhang W
      type: Person
      first name: Wenting
      last name: Zhang
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 2
    item: Liu H
      type: Person
      first name: Huanyu
      last name: Liu
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 3
    item: Chen Y
      type: Person
      first name: Yiye
      last name: Chen
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 4
    item: Zhang X
      type: Person
      first name: Xuerui
      last name: Zhang
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 5
    item: Gu VY
      type: Person
      first name: Victoria Y
      last name: Gu
      member of: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  slot:
    index: 6
    item: Xiao H
      type: Person
      first name: Haodong
      last name: Xiao
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 7
    item: Yang Y
      type: Person
      first name: Yuan
      last name: Yang
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 8
    item: Yin J
      type: Person
      first name: Jiawei
      last name: Yin
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 9
    item: Peng J
      type: Person
      first name: Jie
      last name: Peng
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  slot:
    index: 10
    item: Zhao P
      type: Person
      first name: Peiquan
      last name: Zhao
      member of: Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
created: 2024-1-18T12:42
date last updated: 2025-01-20
issued: 2024-02-01
dp: 2024 Feb 01
created: 2024-1-18T11:42
e ISSN: 2168-6173
has issn l: 2168-6165
issue: 2
has NLM journal title abbreviation: JAMA Ophthalmol
publication name: JAMA ophthalmology
language: eng
has national library of medicine journal id: 101589539
derived from: NLM
starting page: 133
ending page: 139
has place of publication: United States
has primary subject term: D012163Q000209
has primary subject term: D012178Q000175Q000188
has subject term: D007231
has subject term: D006801
has subject term: D008297
has subject term: D002648
has subject term: D002675
has subject term: D005260
has subject term: http://id.nlm.nih.gov/mesh/D000069579
has subject term: D020533Q000627
has subject term: D042461
has subject term: D000080345Q000150Q000188
has subject term: http://id.nlm.nih.gov/mesh/D000097807
has subject term: D002681
has subject term: D012189
has subject term: D058449
has subject term: http://id.nlm.nih.gov/mesh/D000068258
source: JAMA Ophthalmol. 2024-02-01;142(2):133-139.
volume: 142

Physical Function Trajectories and Mortality in Older Adults With Multisensory Impairment.
pmid: 38236596
abstract: Single sensory impairment is associated with reduced functional resilience and increased mortality, though the effects of multiple sensory deficits are not known.To investigate longitudinal associations of the type, severity, and number of sensory impairments with physical function trajectories and mortality in older adults.This retrospective analysis of a longitudinal cohort study, the Health, Aging, and Body Composition (Health ABC) study, incorporated data from April 1997 to July 2013, featuring a 16-year follow-up with annual examinations and questionnaires. The cohort comprised 3075 men and women, aged 70 to 79 years at baseline, residing in Memphis, Tennessee, and Pittsburgh, Pennsylvania. All participants with complete sensory testing and covariate data at analytical baseline (year 5, 2002) were included. The data were analyzed September 1, 2022.Visual, olfactory, auditory, and touch sensory functions were assessed between 2000 and 2002.The main outcomes included physical functioning trajectories and mortality risk. Physical function was assessed longitudinally using the Health ABC physical performance battery (HABCPPB).A total of 1825 individuals (mean [SD] age, 77.4 [3.2] years; 957 [52%] female) were included in this study. Multivariable analysis of HABCPPB decline indicated that having 1 sensory impairment (β estimate, -0.01 [95% CI, -0.02 to -0.001]); 2 sensory impairments (β estimate, -0.01 [95% CI, -0.02 to -0.01]); 3 sensory impairments (β estimate, -0.03 [95% CI, -0.04 to -0.02]); or 4 sensory impairments (β estimate, -0.04 [95% CI, -0.05,-0.03]) was significantly associated with a steeper HABCPPB score decline in a dose-dependent manner. Adjusted Cox proportional hazards models indicated that having 1 sensory impairment (hazard ratio [HR], 1.35 [95% CI, 1.01-1.81]), 2 sensory impairments (HR, 1.58 [95% CI, 1.19-2.11]), 3 sensory impairments (HR, 1.79 [95% CI, 1.33-2.42]), or 4 sensory impairments (HR, 1.97 [95% CI, 1.39-2.79]) was significantly asso[cell cut: 2436 characters, first 2000 kept]
has PII: 2814084
doi: 10.1001/jamaoto.2023.4378
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Vohra V
      type: Person
      first name: Varun
      last name: Vohra
      member of: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
  slot:
    index: 2
    item: Simonsick EM
      type: Person
      first name: Eleanor M
      last name: Simonsick
      member of: National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland.
  slot:
    index: 3
    item: Kamath V
      type: Person
      first name: Vidyulata
      last name: Kamath
      member of: Department of Psychiatry and Behavior Sciences, Johns Hopkins University, Baltimore, Maryland.
  slot:
    index: 4
    item: Bandeen-Roche K
      type: Person
      first name: Karen
      last name: Bandeen-Roche
      member of: Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland.
  slot:
    index: 5
    item: Agrawal Y
      type: Person
      first name: Yuri
      last name: Agrawal
      member of: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
  slot:
    index: 6
    item: Rowan NR
      type: Person
      first name: Nicholas R
      last name: Rowan
      member of: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland.
created: 2024-1-18T12:42
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 03 01
created: 2024-1-18T11:42
e ISSN: 2168-619X
has issn l: 2168-6181
issue: 3
has NLM journal title abbreviation: JAMA Otolaryngol Head Neck Surg
publication name: JAMA otolaryngology-- head & neck surgery
language: eng
has national library of medicine journal id: 101589542
derived from: NLM
starting page: 217
ending page: 225
has place of publication: United States
has primary subject term: D008137
has subject term: D008297
has subject term: D006801
has subject term: D005260
has subject term: D000368
has subject term: D012189
has subject term: D015331
has subject term: D016016
has subject term: D010414Q000453
source: JAMA Otolaryngol Head Neck Surg. 2024-03-01;150(3):217-225.
volume: 150

Pneumocystis jirovecii pneumonia in people living with HIV: a review.
pmid: 38235979
abstract: Pneumocystis jirovecii is a ubiquitous opportunistic fungus that can cause life-threatening pneumonia. People with HIV (PWH) who have low CD4 counts are one of the populations at the greatest risk of Pneumocystis jirovecii pneumonia (PCP). While guidelines have approached the diagnosis, prophylaxis, and management of PCP, the numerous studies of PCP in PWH are dominated by the 1980s and 1990s. As such, most studies have included younger male populations, despite PCP affecting both sexes and a broad age range. Many studies have been small and observational in nature, with an overall lack of randomized controlled trials. In many jurisdictions, and especially in low- and middle-income countries, the diagnosis can be challenging due to lack of access to advanced and/or invasive diagnostics. Worldwide, most patients will be treated with 21 days of high-dose trimethoprim sulfamethoxazole, although both the dose and the duration are primarily based on historical practice. Whether treatment with a lower dose is as effective and less toxic is gaining interest based on observational studies. Similarly, a 21-day tapering regimen of prednisone is used for patients with more severe disease, yet other doses, other steroids, or shorter durations of treatment with corticosteroids have not been evaluated. Now with the widespread availability of antiretroviral therapy, improved and less invasive PCP diagnostic techniques, and interest in novel treatment strategies, this review consolidates the scientific body of literature on the diagnosis and management of PCP in PWH, as well as identifies areas in need of more study and thoughtfully designed clinical trials.
doi: 10.1128/cmr.00101-22
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: McDonald EG
      type: Person
      first name: Emily G
      last name: McDonald
      member of: Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.Division of Experimental Medicine, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.Canadian Medication Appropriateness and Deprescribing Network, Montreal, Quebec, Canada.
  slot:
    index: 2
    item: Afshar A
      type: Person
      first name: Avideh
      last name: Afshar
      member of: Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
  slot:
    index: 3
    item: Assiri B
      type: Person
      first name: Bander
      last name: Assiri
      member of: Division of Experimental Medicine, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
  slot:
    index: 4
    item: Boyles T
      type: Person
      first name: Tom
      last name: Boyles
      member of: Right to Care, NPC, Centurion, South Africa.London School of Hygiene and Tropical Medicine, London, United Kingdom.
  slot:
    index: 5
    item: Hsu JM
      type: Person
      first name: Jimmy M
      last name: Hsu
      member of: Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
  slot:
    index: 6
    item: Khuong N
      type: Person
      first name: Ninh
      last name: Khuong
      member of: Canadian Medication Appropriateness and Deprescribing Network, Montreal, Quebec, Canada.
  slot:
    index: 7
    item: Prosty C
      type: Person
      first name: Connor
      last name: Prosty
      member of: Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
  slot:
    index: 8
    item: So M
      type: Person
      first name: Miranda
      last name: So
      member of: Sinai Health System-University Health Network Antimicrobial Stewardship Program, University of Toronto, Toronto, Canada.Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.
  slot:
    index: 9
    item: Sohani ZN
      type: Person
      first name: Zahra N
      last name: Sohani
      member of: Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
  slot:
    index: 10
    item: Butler-Laporte G
      type: Person
      first name: Guillaume
      last name: Butler-Laporte
      member of: Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
  slot:
    index: 11
    item: Lee TC
      type: Person
      first name: Todd C
      last name: Lee
      member of: Division of Experimental Medicine, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
created: 2024-1-18T12:43
date last updated: 2025-01-20
issued: 2024-03-14
dp: 2024 03 14
created: 2024-1-18T08:36
e ISSN: 1098-6618
has issn l: 0893-8512
issue: 1
has NLM journal title abbreviation: Clin Microbiol Rev
publication name: Clinical microbiology reviews
language: eng
has national library of medicine journal id: 8807282
derived from: NLM
pg: e0010122
has place of publication: United States
has primary subject term: D011020Q000175Q000188Q000517
has primary subject term: D045363
has primary subject term: D015658Q000150Q000188
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D015662Q000627Q000494
source: Clin Microbiol Rev. 2024-03-14;37(1):e0010122.
volume: 37

Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.
pmid: 38236720
abstract: Aggregation prone molecules, such as tau, form both historically well characterized fibrillar deposits (neurofibrillary tangles) and recently identified phosphate-buffered saline (PBS) extract species called proteopathic seeds. Both can cause normal endogenous tau to undergo templated misfolding. The relationship of these seeds to the fibrils that define tau-related diseases is unknown. We characterized the aqueous extractable and sarkosyl insoluble fibrillar tau species derived from human Alzheimer brain using mass spectrometry and in vitro bioassays. Post-translational modifications (PTMs) including phosphorylation, acetylation and ubiquitination are identified in both preparations. PBS extract seed competent tau can be distinguished from sarkosyl insoluble tau by the presence of overlapping, but less abundant, PTMs and an absence of some PTMs unique to the latter. The presence of ubiquitin and other PTMs on the PBS-extracted tau species correlates with the amount of tau in the seed competent size exclusion fractions, with the bioactivity and with the aggressiveness of clinical disease. These results demonstrate that the PTMs present on bioactive, seed competent PBS extract tau species are closely related to, but distinct from, the PTMs of mature paired helical filaments, consistent with the idea that they are a forme fruste of tau species that ultimately form fibrils.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7471794
doi: 10.1093/brain/awad378
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Kumar M
      type: Person
      first name: Mukesh
      last name: Kumar
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 2
    item: Quittot N
      type: Person
      first name: Noé
      last name: Quittot
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 3
    item: Dujardin S
      type: Person
      first name: Simon
      last name: Dujardin
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 4
    item: Schlaffner CN
      type: Person
      first name: Christoph N
      last name: Schlaffner
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 5
    item: Viode A
      type: Person
      first name: Arthur
      last name: Viode
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 6
    item: Wiedmer A
      type: Person
      first name: Anne
      last name: Wiedmer
      member of: Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 7
    item: Beerepoot P
      type: Person
      first name: Pieter
      last name: Beerepoot
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 8
    item: Chun JE
      type: Person
      first name: Joshua E
      last name: Chun
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 9
    item: Glynn C
      type: Person
      first name: Calina
      last name: Glynn
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 10
    item: Fernandes AR
      type: Person
      first name: Analiese R
      last name: Fernandes
      member of: Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 11
    item: Donahue C
      type: Person
      first name: Cameron
      last name: Donahue
      member of: Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  slot:
    index: 12
    item: Steen JA
      type: Person
      first name: Judith A
      last name: Steen
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
  slot:
    index: 13
    item: Hyman BT
      type: Person
      first name: Bradley T
      last name: Hyman
      member of: Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
created: 2024-1-18T18:42
date last updated: 2025-01-20
issued: 2024-02-01
dp: 2024 02 01
created: 2024-1-18T12:53
e ISSN: 1460-2156
has issn l: 0006-8950
issue: 2
has NLM journal title abbreviation: Brain
publication name: Brain : a journal of neurology
language: eng
has national library of medicine journal id: 0372537
derived from: NLM
starting page: 637
ending page: 648
has place of publication: England
has primary subject term: D016874Q000378
has primary subject term: D000544Q000378
has subject term: D006801
has subject term: D016875Q000378
has subject term: D011499
has subject term: D010766
source: Brain. 2024-02-01;147(2):637-648.
volume: 147

Macrophage Heterogeneity and Efferocytosis: Beyond the M1/M2 Dichotomy.
pmid: 38236949
doi: 10.1161/CIRCRESAHA.123.324011
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kumar Jha P
      type: Person
      first name: Prabhash
      last name: Kumar Jha
      member of: Center for Excellence in Vascular Biology (P.K.J., M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston.
  slot:
    index: 2
    item: Aikawa M
      type: Person
      first name: Masanori
      last name: Aikawa
      member of: Center for Excellence in Vascular Biology (P.K.J., M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston.Center for Interdisciplinary Cardiovascular Sciences (M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston.Channing Division of Network Medicine (M.A.), Brigham and Women's Hospital, Harvard Medical School, Boston.
  slot:
    index: 3
    item: Aikawa E
      type: Person
      first name: Elena
      last name: Aikawa
      member of: Center for Excellence in Vascular Biology (P.K.J., M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston.Center for Interdisciplinary Cardiovascular Sciences (M.A., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston.
created: 2024-1-18T18:42
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2024-1-18T14:04
e ISSN: 1524-4571
has issn l: 0009-7330
issue: 2
has NLM journal title abbreviation: Circ Res
publication name: Circulation research
language: eng
has national library of medicine journal id: 0047103
derived from: NLM
starting page: 186
ending page: 188
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000097242
has primary subject term: D008264
has subject term: D006801
has subject term: D010587
has subject term: D007249
source: Circ Res. 2024-01-19;134(2):186-188.
volume: 134

Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer.
pmid: 38237099
abstract: Recurrence after curative-intent treatment occurs in 20%-50% of patients with stage II-IV colorectal cancer (CRC), underscoring the need for early detection of minimal residual disease (MRD) using circulating tumor DNA (ctDNA). Here, we examined the pattern of use of a tumor-informed ctDNA assay in CRC MRD monitoring in routine clinical practice at Mayo Clinic, Rochester.We conducted a retrospective analysis of health records of patients with CRC who had at least one tumor-informed ctDNA assay from May 2019 through July 1, 2022. Recurrence was defined as radiographic evidence of disease. Descriptive characteristics of the cohort, ctDNA results, and subsequent interventions were recorded.Of the 120 patients included, the median age at diagnosis was 67 years, 46% were female, and 94% were White. At diagnosis, 10 patients had stage I, 23 stage II, 60 stage III, and 25 stage IV disease. Of 476 ctDNA assays performed, 70% were performed in patients who had recurrent disease most commonly to monitor the effectiveness of therapeutic interventions and 16% resulted in a change in clinical decision making. There were 110 recurrences identified in 62 patients, as some patients experienced more than one recurrence over time. Compared with serum carcinoembryonic antigen levels, ctDNA results correlated better with radiologic imaging.Routine ctDNA monitoring for MRD detection has been adopted in clinical practice; however, 84% of ctDNA assays performed did not result in a change in clinical management. This suggests the need for further clinical research data to guide routine clinical use of ctDNA MRD testing in CRC.
doi: 10.1200/PO.23.00127
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Emiloju OE
      type: Person
      first name: Oluwadunni E
      last name: Emiloju
      member of: Division of Oncology, Mayo Clinic, Rochester, MN.
  slot:
    index: 2
    item: Storandt M
      type: Person
      first name: Michael
      last name: Storandt
      member of: Department of Medicine, Mayo Clinic, Rochester, MN.
  slot:
    index: 3
    item: Zemla T
      type: Person
      first name: Tyler
      last name: Zemla
      member of: Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
  slot:
    index: 4
    item: Tran N
      type: Person
      first name: Nguyen
      last name: Tran
      member of: Division of Oncology, Mayo Clinic, Rochester, MN.
  slot:
    index: 5
    item: Jethwa K
      type: Person
      first name: Krishan
      last name: Jethwa
      member of: Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
  slot:
    index: 6
    item: Mahipal A
      type: Person
      first name: Amit
      last name: Mahipal
      member of: Department of Hematology and Oncology, University Hospitals, Cleveland, OH.
  slot:
    index: 7
    item: Mitchell J
      type: Person
      first name: Jessica
      last name: Mitchell
      member of: Department of Medicine, Mayo Clinic, Rochester, MN.
  slot:
    index: 8
    item: Thiels C
      type: Person
      first name: Cornelius
      last name: Thiels
      member of: Department of Surgery, Mayo Clinic, Rochester, MN.
  slot:
    index: 9
    item: Mathis K
      type: Person
      first name: Kellie
      last name: Mathis
      member of: Department of Surgery, Mayo Clinic, Rochester, MN.
  slot:
    index: 10
    item: McWilliams R
      type: Person
      first name: Robert
      last name: McWilliams
      member of: Department of Medicine, Mayo Clinic, Rochester, MN.
  slot:
    index: 11
    item: Hubbard J
      type: Person
      first name: Joleen
      last name: Hubbard
      member of: Department of Medicine, Mayo Clinic, Rochester, MN.
  slot:
    index: 12
    item: Sinicrope F
      type: Person
      first name: Frank
      last name: Sinicrope
      member of: Division of Oncology, Mayo Clinic, Rochester, MN.Department of Medicine, Mayo Clinic, Rochester, MN.
  slot:
    index: 13
    item: Shi Q
      type: Person
      first name: Qian
      last name: Shi
      member of: Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
  slot:
    index: 14
    item: Jin Z
      type: Person
      first name: Zhaohui
      last name: Jin
      member of: Division of Oncology, Mayo Clinic, Rochester, MN.
created: 2024-1-18T18:42
date last updated: 2025-01-20
issued: 2024-01
dp: 2024 Jan
created: 2024-1-18T16:03
e ISSN: 2473-4284
has issn l: 2473-4284
has NLM journal title abbreviation: JCO Precis Oncol
publication name: JCO precision oncology
language: eng
has national library of medicine journal id: 101705370
derived from: NLM
pg: e2300127
has place of publication: United States
has primary subject term: D000074141Q000235
has primary subject term: http://id.nlm.nih.gov/mesh/D000073888
has primary subject term: D015179Q000175Q000235
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D018365Q000175Q000235
has subject term: D012189
has subject term: D004273Q000235
source: JCO Precis Oncol. 2024-01;8():e2300127.
volume: 8

Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma.
pmid: 38237157
abstract: Glioblastomas (GBMs) are central nervous system tumors that resist standard-of-care interventions and even immune checkpoint blockade. Myeloid cells in the tumor microenvironment can contribute to GBM progression; therefore, emerging immunotherapeutic approaches include reprogramming these cells to achieve desirable antitumor activity. Triggering receptor expressed on myeloid cells 2 (TREM2) is a myeloid signaling regulator that has been implicated in a variety of cancers and neurological diseases with contrasting functions, but its role in GBM immunopathology and progression is still under investigation.Our reverse translational investigations leveraged single-cell RNA sequencing and cytometry of human gliomas to characterize TREM2 expression across myeloid subpopulations. Using 2 distinct murine glioma models, we examined the role of Trem2 on tumor progression and immune modulation of myeloid cells. Furthermore, we designed a method of tracking phagocytosis of glioma cells in vivo and employed in vitro assays to mechanistically understand the influence of TREM2 signaling on tumor uptake.We discovered that TREM2 expression does not correlate with immunosuppressive pathways, but rather showed strong a positive association with the canonical phagocytosis markers lysozyme (LYZ) and macrophage scavenger receptor (CD163) in gliomas. While Trem2 deficiency was found to be dispensable for gliomagenesis, Trem2+ myeloid cells display enhanced tumor uptake compared to Trem2- cells. Mechanistically, we demonstrate that TREM2 mediates phagocytosis via Syk signaling.These results indicate that TREM2 is not associated with immunosuppression in gliomas. Instead, TREM2 is an important regulator of phagocytosis that may be exploited as a potential therapeutic strategy for brain tumors.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7572941
doi: 10.1093/neuonc/noad257
creator: OrderedList
  length: 21
  slot:
    index: 1
    item: Peshoff MM
      type: Person
      first name: Mekenzie M
      last name: Peshoff
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.Department of Translational Molecular Pathology, The University of Texas, MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, USA.
  slot:
    index: 2
    item: Gupta P
      type: Person
      first name: Pravesh
      last name: Gupta
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 3
    item: Oberai S
      type: Person
      first name: Shivangi
      last name: Oberai
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 4
    item: Trivedi R
      type: Person
      first name: Rakesh
      last name: Trivedi
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 5
    item: Katayama H
      type: Person
      first name: Hiroshi
      last name: Katayama
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 6
    item: Chakrapani P
      type: Person
      first name: Prashanth
      last name: Chakrapani
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 7
    item: Dang M
      type: Person
      first name: Minghao
      last name: Dang
      member of: Department of Genomic Medicine, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 8
    item: Migliozzi S
      type: Person
      first name: Simona
      last name: Migliozzi
      member of: Department of Neurological Surgery, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, Miami, Florida, USA.
  slot:
    index: 9
    item: Gumin J
      type: Person
      first name: Joy
      last name: Gumin
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 10
    item: Kadri DB
      type: Person
      first name: Divya B
      last name: Kadri
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 11
    item: Lin JK
      type: Person
      first name: Jessica K
      last name: Lin
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 12
    item: Milam NK
      type: Person
      first name: Nancy K
      last name: Milam
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 13
    item: Maynard ME
      type: Person
      first name: Mark E
      last name: Maynard
      member of: Department of Electrical and Computer Engineering, University of Houston, Houston, Texas, USA.
  slot:
    index: 14
    item: Vaillant BD
      type: Person
      first name: Brian D
      last name: Vaillant
      member of: Departments of Translational Molecular Pathology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
  slot:
    index: 15
    item: Parker-Kerrigan B
      type: Person
      first name: Brittany
      last name: Parker-Kerrigan
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 16
    item: Lang FF
      type: Person
      first name: Frederick F
      last name: Lang
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 17
    item: Huse JT
      type: Person
      first name: Jason T
      last name: Huse
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.Department of Translational Molecular Pathology, The University of Texas, MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, USA.
  slot:
    index: 18
    item: Iavarone A
      type: Person
      first name: Antonio
      last name: Iavarone
      member of: Department of Neurological Surgery, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, Miami, Florida, USA.
  slot:
    index: 19
    item: Wang L
      type: Person
      first name: Linghua
      last name: Wang
      member of: Department of Genomic Medicine, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 20
    item: Clise-Dwyer K
      type: Person
      first name: Karen
      last name: Clise-Dwyer
      member of: Department of Hematopoietic Biology & Malignancy, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 21
    item: Bhat KP
      type: Person
      first name: Krishna P
      last name: Bhat
      member of: Department of Translational Molecular Pathology, Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.Department of Translational Molecular Pathology, The University of Texas, MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, USA.
created: 2024-1-18T18:42
date last updated: 2025-01-20
issued: 2024-05-03
dp: 2024 05 03
created: 2024-1-18T17:03
e ISSN: 1523-5866
has issn l: 1522-8517
issue: 5
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
starting page: 826
ending page: 839
has place of publication: England
has primary subject term: D011971Q000378Q000235
has primary subject term: D005909Q000378Q000473Q000235
has primary subject term: D008562Q000378Q000235
has primary subject term: D010587
has primary subject term: D001932Q000378Q000473Q000235
has subject term: D000818
has subject term: D051379
has subject term: D006801
has subject term: D059016
has subject term: D022423Q000378
has subject term: D008810
has subject term: D014407
has subject term: D015398
source: Neuro Oncol. 2024-05-03;26(5):826-839.
volume: 26

Platelet Mitochondrial Fusion and Function in Vascular Integrity.
pmid: 38236952
doi: 10.1161/CIRCRESAHA.123.323867
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Tyagi T
      type: Person
      first name: Tarun
      last name: Tyagi
      member of: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (T.T., T.O.Y., J.H.), Yale University School of Medicine, New Haven, CT.
  slot:
    index: 2
    item: Yarovinsky TO
      type: Person
      first name: Timur O
      last name: Yarovinsky
      member of: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (T.T., T.O.Y., J.H.), Yale University School of Medicine, New Haven, CT.
  slot:
    index: 3
    item: Faustino EVS
      type: Person
      first name: E Vincent S
      last name: Faustino
      member of: Section of Critical Care, Department of Pediatrics (E.V.S.F.), Yale University School of Medicine, New Haven, CT.
  slot:
    index: 4
    item: Hwa J
      type: Person
      first name: John
      last name: Hwa
      member of: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (T.T., T.O.Y., J.H.), Yale University School of Medicine, New Haven, CT.Yale Cooperative Center of Excellence in Hematology (J.H.), Yale University School of Medicine, New Haven, CT.
created: 2024-1-18T18:42
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2024-1-18T14:04
e ISSN: 1524-4571
has issn l: 0009-7330
issue: 2
has NLM journal title abbreviation: Circ Res
publication name: Circulation research
language: eng
has national library of medicine journal id: 0047103
derived from: NLM
starting page: 162
ending page: 164
has place of publication: United States
has primary subject term: D063154
has primary subject term: D001792
has subject term: D008533
has subject term: D006487
has subject term: D015539
source: Circ Res. 2024-01-19;134(2):162-164.
volume: 134

Reply: Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease.
pmid: 38237997
has PII: 63/1/2302146
doi: 10.1183/13993003.02146-2023
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Zhang D
      type: Person
      first name: David
      last name: Zhang
      member of: Division of Pulmonary and Critical Care Medicine, Columbia University, New York, NY, USA.
  slot:
    index: 2
    item: Adegunsoye A
      type: Person
      first name: Ayodeji
      last name: Adegunsoye
      member of: Section of Pulmonary and Critical Care, University of Chicago, Chicago, IL, USA.
  slot:
    index: 3
    item: Oldham JM
      type: Person
      first name: Justin M
      last name: Oldham
      member of: Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
  slot:
    index: 4
    item: Wolters PJ
      type: Person
      first name: Paul J
      last name: Wolters
      member of: Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 5
    item: Garcia CK
      type: Person
      first name: Christine Kim
      last name: Garcia
      member of: Division of Pulmonary and Critical Care Medicine, Columbia University, New York, NY, USA.
  slot:
    index: 6
    item: Newton CA
      type: Person
      first name: Chad A
      last name: Newton
      member of: Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA chad.newton@utsouthwestern.edu.
created: 2024-1-19T00:42
date last updated: 2025-01-20
issued: 2024-01
dp: 2024 Jan
created: 2024-1-18T21:02
e ISSN: 1399-3003
has issn l: 0903-1936
issue: 1
has NLM journal title abbreviation: Eur Respir J
publication name: The European respiratory journal
language: eng
has national library of medicine journal id: 8803460
derived from: NLM
has place of publication: England
has primary subject term: D011658Q000235
has primary subject term: D017563
has subject term: D006801
has subject term: D007165
has subject term: D016615
source: Eur Respir J. 2024-01;63(1):.
volume: 63

VLDL Biogenesis and Secretion: It Takes a Village.
pmid: 38236950
abstract: The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a direct impact on liver fat content, as well as the concentrations of cholesterol and triglycerides in the circulation and thus affects both liver and cardiovascular health, respectively. Importantly, insulin resistance, excess caloric intake, and lack of physical activity are associated with overproduction of VLDL, hepatic steatosis, and increased plasma levels of atherogenic lipoproteins. Cholesterol and triglycerides in remnant particles generated by VLDL lipolysis are risk factors for atherosclerotic cardiovascular disease and have garnered increasing attention over the last few decades. Presently, however, increased risk of atherosclerosis is not the only concern when considering today's cardiometabolic patients, as they often also experience hepatic steatosis, a prevalent disorder that can progress to steatohepatitis and cirrhosis. This duality of metabolic risk highlights the importance of understanding the molecular regulation of the biogenesis of VLDL, the lipoprotein that transports triglycerides and cholesterol out of the liver. Fortunately, there has been a resurgence of interest in the intracellular assembly, trafficking, degradation, and secretion of VLDL by hepatocytes, which has led to many exciting new molecular insights that are the topic of this review. Increasing our understanding of the biology of this pathway will aid to the identification of novel therapeutic targets to improve both the cardiovascular and the hepatic health of cardiometabolic patients. This review focuses, for the first time, on this duality.
doi: 10.1161/CIRCRESAHA.123.323284
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: van Zwol W
      type: Person
      first name: Willemien
      last name: van Zwol
      member of: Department of Paediatrics, University Medical Center Groningen, University of Groningen, the Netherlands (W.v.Z., B.v.d.S., J.A.K.).
  slot:
    index: 2
    item: van de Sluis B
      type: Person
      first name: Bart
      last name: van de Sluis
      member of: Department of Paediatrics, University Medical Center Groningen, University of Groningen, the Netherlands (W.v.Z., B.v.d.S., J.A.K.).
  slot:
    index: 3
    item: Ginsberg HN
      type: Person
      first name: Henry N
      last name: Ginsberg
      member of: Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (H.N.G.).
  slot:
    index: 4
    item: Kuivenhoven JA
      type: Person
      first name: Jan Albert
      last name: Kuivenhoven
      member of: Department of Paediatrics, University Medical Center Groningen, University of Groningen, the Netherlands (W.v.Z., B.v.d.S., J.A.K.).
created: 2024-1-18T18:42
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 01 19
created: 2024-1-18T14:04
e ISSN: 1524-4571
has issn l: 0009-7330
issue: 2
has NLM journal title abbreviation: Circ Res
publication name: Circulation research
language: eng
has national library of medicine journal id: 0047103
derived from: NLM
starting page: 226
ending page: 244
has place of publication: United States
has primary subject term: D005234Q000378
has primary subject term: D002318Q000378
has subject term: D006801
has subject term: D008074
has subject term: D008079
has subject term: D014280
has subject term: D008099Q000378
has subject term: D002784Q000378
source: Circ Res. 2024-01-19;134(2):226-244.
volume: 134

Time-series blood cytokine profiles correlate with treatment responses in triple-negative breast cancer patients.
pmid: 38238427
abstract: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes.In this study, we examined blood cytokine profiles of TNBC patients throughout treatments (pre-treatment, during chemotherapy, pre-surgery, and 1 year after the surgery in a total of 294 samples). We analyzed the obtained cytokine datasets using weighted correlation network analyses, protein-protein interaction analyses, and logistic regression analyses.We identified five cytokines that correlate with good clinical outcomes: interleukin (IL)-1α, TNF-related apoptosis-inducing ligand (TRAIL), Stem Cell Factor (SCF), Chemokine ligand 5 (CCL5 also known as RANTES), and IL-16. The expression of these cytokines was decreased during chemotherapy and then restored after the treatment. Importantly, patients with good clinical outcomes had constitutively high expression of these cytokines during treatments. Protein-protein interaction analyses implicated that these five cytokines promote an immune response. Logistic regression analyses revealed that IL-1α and TRAIL expression levels at pre-treatment could predict treatment outcomes in our cohort.We concluded that time-series cytokine profiles in breast cancer patients may be useful for understanding immune cell activity during treatment and for predicting treatment outcomes, supporting precision medicine.The study has been registered with the University Hospital Medical Information Network Clinical Trials Registry ( http://www.umin.ac.jp/ctr/index-j.htm ) with the unique trial number UMIN000023162. The association Japan Breast Cancer Research Group trial number is JBCRG-22. The clinical outcome of the JBCRG-22 study was published in Breast Cancer Research and Treatment on 25 March 2021. https://doi.org/10.1007/s10549-021-06184-w .
rights: © 2024. The Author(s), under exclusive licence to Springer Nature Limited.
has PII: 10.1038/s41416-023-02527-0
doi: 10.1038/s41416-023-02527-0
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Saldajeno DP
      type: Person
      first name: Don Pietro
      last name: Saldajeno
      member of: Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.Mathematical Informatics Laboratory, Division of Information Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
  slot:
    index: 2
    item: Kawaoka S
      type: Person
      first name: Shinpei
      last name: Kawaoka
      member of: Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan.
  slot:
    index: 3
    item: Masuda N
      type: Person
      first name: Norikazu
      last name: Masuda
      member of: Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
  slot:
    index: 4
    item: Tanaka S
      type: Person
      first name: Sunao
      last name: Tanaka
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 5
    item: Bando H
      type: Person
      first name: Hiroko
      last name: Bando
      member of: Breast and Endocrine Surgery, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  slot:
    index: 6
    item: Nishimura T
      type: Person
      first name: Tomomi
      last name: Nishimura
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.Department of Next-generation Clinical Genomic Medicine, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  slot:
    index: 7
    item: Kadoya T
      type: Person
      first name: Takayuki
      last name: Kadoya
      member of: Department of Breast Surgery, Shimane University Hospital, Enyacho 89-1, Izumo, Shimane, 693-0021, Japan.
  slot:
    index: 8
    item: Yamanaka T
      type: Person
      first name: Takashi
      last name: Yamanaka
      member of: Department of Breast Surgery and Oncology, Kanagawa Cancer Center, 2-3-2 Nakano, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan.
  slot:
    index: 9
    item: Imoto S
      type: Person
      first name: Shigeru
      last name: Imoto
      member of: Department of Breast Surgery, Kyorin University Hospital, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.
  slot:
    index: 10
    item: Velaga RM
      type: Person
      first name: Ravindranath M
      last name: Velaga
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 11
    item: Tamura N
      type: Person
      first name: Nobuko
      last name: Tamura
      member of: Department of Breast and Endocrine Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.
  slot:
    index: 12
    item: Aruga T
      type: Person
      first name: Tomoyuki
      last name: Aruga
      member of: Department of Breast Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.
  slot:
    index: 13
    item: Ikeda K
      type: Person
      first name: Kazushi
      last name: Ikeda
      member of: Mathematical Informatics Laboratory, Division of Information Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
  slot:
    index: 14
    item: Fukui Y
      type: Person
      first name: Yukiko
      last name: Fukui
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 15
    item: Maeshima Y
      type: Person
      first name: Yurina
      last name: Maeshima
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 16
    item: Takada M
      type: Person
      first name: Masahiro
      last name: Takada
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 17
    item: Suzuki E
      type: Person
      first name: Eiji
      last name: Suzuki
      member of: Department of Breast Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojimaminamimachi Chuo-ku, Kobe-shi, Hyogo, 650-0047, Japan.
  slot:
    index: 18
    item: Ueno T
      type: Person
      first name: Takayuki
      last name: Ueno
      member of: Breast Surgical Oncology, The Cancer Institute Hospital of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  slot:
    index: 19
    item: Ogawa S
      type: Person
      first name: Seishi
      last name: Ogawa
      member of: Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.Department of Pathology and Tumor Biology, Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
  slot:
    index: 20
    item: Haga H
      type: Person
      first name: Hironori
      last name: Haga
      member of: Department of Diagnostic Pathology, Kyoto University Hospital, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 21
    item: Ohno S
      type: Person
      first name: Shinji
      last name: Ohno
      member of: Breast Oncology Center, The Cancer Institute Hospital of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  slot:
    index: 22
    item: Morita S
      type: Person
      first name: Satoshi
      last name: Morita
      member of: Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan.
  slot:
    index: 23
    item: Kawaguchi K
      type: Person
      first name: Kosuke
      last name: Kawaguchi
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan. kkosuke@kuhp.kyoto-u.ac.jp.
  slot:
    index: 24
    item: Toi M
      type: Person
      first name: Masakazu
      last name: Toi
      member of: Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, 54 Kawahara-cho, Shogoin Sakyo-ku, Kyoto, 606-8507, Japan. toi@kuhp.kyoto-u.ac.jp.Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan. toi@kuhp.kyoto-u.ac.jp.
created: 2024-1-19T00:42
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 Apr
created: 2024-1-18T23:21
e ISSN: 1532-1827
has issn l: 0007-0920
issue: 6
has NLM journal title abbreviation: Br J Cancer
publication name: British journal of cancer
language: eng
has national library of medicine journal id: 0370635
derived from: NLM
starting page: 1023
ending page: 1035
has place of publication: England
has primary subject term: D064726Q000188Q000378
has subject term: D006801
has subject term: D016207Q000378
has subject term: D018925
has subject term: D016896
has subject term: D007564
source: Br J Cancer. 2024-04;130(6):1023-1035.
volume: 130

Vitamin D deficiency promotes intracranial aneurysm rupture.
pmid: 38241458
abstract: Intracranial aneurysm rupture causes severe disability and high mortality. Epidemiological studies show a strong association between decreased vitamin D levels and an increase in aneurysm rupture. However, the causality and mechanism remain largely unknown. In this study, we tested whether vitamin D deficiency promotes aneurysm rupture and examined the underlying mechanism for the protective role of vitamin D against the development of aneurysm rupture utilizing a mouse model of intracranial aneurysm. Mice consuming a vitamin D-deficient diet had a higher rupture rate than mice with a regular diet. Vitamin D deficiency increased proinflammatory cytokines in the cerebral arteries. Concurrently, vitamin D receptor knockout mice had a higher rupture rate than the corresponding wild-type littermates. The vitamin D receptors on endothelial and vascular smooth muscle cells, but not on hematopoietic cells, mediated the effect of aneurysm rupture. Our results establish that vitamin D protects against the development of aneurysmal rupture through the vitamin D receptors on vascular endothelial and smooth muscle cells. Vitamin D supplementation may be a viable pharmacologic therapy for preventing aneurysm rupture.
doi: 10.1177/0271678X241226750
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Kimura T
      type: Person
      first name: Tetsuro
      last name: Kimura
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 2
    item: Rahmani R
      type: Person
      first name: Redi
      last name: Rahmani
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA.
  slot:
    index: 3
    item: Miyamoto T
      type: Person
      first name: Takeshi
      last name: Miyamoto
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 4
    item: Kamio Y
      type: Person
      first name: Yoshinobu
      last name: Kamio
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 5
    item: Kudo D
      type: Person
      first name: Daisuke
      last name: Kudo
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 6
    item: Sato H
      type: Person
      first name: Hiroki
      last name: Sato
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 7
    item: Ikedo T
      type: Person
      first name: Taichi
      last name: Ikedo
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 8
    item: Baranoski JF
      type: Person
      first name: Jacob F
      last name: Baranoski
      member of: Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 9
    item: Uchikawa H
      type: Person
      first name: Hiroki
      last name: Uchikawa
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 10
    item: Ai J
      type: Person
      first name: Jinglu
      last name: Ai
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 11
    item: Lawton MT
      type: Person
      first name: Michael T
      last name: Lawton
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.
  slot:
    index: 12
    item: Hashimoto T
      type: Person
      first name: Tomoki
      last name: Hashimoto
      member of: Barrow Aneurysm and AVM Research Center, Barrow Neurological Institute, Phoenix, Arizona, USA.
created: 2024-1-19T18:30
date last updated: 2025-01-20
issued: 2024-07
dp: 2024 Jul
created: 2024-1-19T14:32
e ISSN: 1559-7016
has issn l: 0271-678X
issue: 7
has NLM journal title abbreviation: J Cereb Blood Flow Metab
publication name: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
language: eng
has national library of medicine journal id: 8112566
derived from: NLM
starting page: 1174
ending page: 1183
has place of publication: United States
has primary subject term: D014808Q000150
has primary subject term: D002532Q000209
has primary subject term: D017542Q000209
has primary subject term: D018345
has primary subject term: D018167Q000378Q000235Q000172
has primary subject term: D014807Q000627Q000097
has subject term: D000818
has subject term: D051379
has subject term: D009131Q000378Q000473
has subject term: D016207Q000378
has subject term: D008810
has subject term: D008297
has subject term: D004195
has subject term: D032389Q000378Q000473
source: J Cereb Blood Flow Metab. 2024-07;44(7):1174-1183.
volume: 44

Advancing the science of visualization of health data for lay audiences.
pmid: 38238784
has PII: 7571518
doi: 10.1093/jamia/ocad255
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Arcia A
      type: Person
      first name: Adriana
      last name: Arcia
      member of: Hahn School of Nursing and Health Science, University of San Diego, San Diego, CA 92110, United States.
  slot:
    index: 2
    item: Benda NC
      type: Person
      first name: Natalie C
      last name: Benda
      member of: School of Nursing, Columbia University, New York, NY 10032, United States.
  slot:
    index: 3
    item: Wu DTY
      type: Person
      first name: Danny T Y
      last name: Wu
      member of: Department of Biomedical Informatics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, United States.
created: 2024-1-19T00:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-18T23:40
e ISSN: 1527-974X
has issn l: 1067-5027
issue: 2
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: 283
ending page: 288
has place of publication: England
has primary subject term: D003142
has primary subject term: D033181
source: J Am Med Inform Assoc. 2024-01-18;31(2):283-288.
volume: 31

Circulating small extracellular vesicle-based miRNA classifier for follicular thyroid carcinoma: a diagnostic study.
pmid: 38238428
abstract: The diagnosis of follicular thyroid carcinoma (FTC) prior to surgery remains a major challenge in the clinic.This multicentre diagnostic study involved 41 and 150 age- and sex-matched patients in the training cohort and validation cohort, respectively. The diagnostic properties of circulating small extracellular vesicle (sEV)-associated and cell-free RNAs were compared by RNA sequencing in the training cohort. Subsequently, using a quantitative real-time polymerase chain reaction (qRT‒PCR) assay, high-quality candidates were identified to construct an RNA classifier for FTC and verified in the validation cohort. The parallel expression, stability and influence of the RNA classifier on surgical strategy were also investigated.The diagnostic properties of sEV long RNAs, cell-free long RNAs and sEV microRNAs (miRNAs) were comparable and superior to those of cell-free miRNAs in RNA sequencing. Given the clinical application, the circulating sEV miRNA (CirsEV-miR) classifier was developed from five miRNAs based on qRT‒PCR data, which could well identify FTC patients (area under curve [AUC] of 0.924 in the training cohort and 0.844 in the multicentre validation cohort). Further tests revealed that the CirsEV-miR score was significantly correlated with the tumour burden, and the levels of sEV miRNAs were also higher in sEVs from the FTC cell line, organoid and tissue. Additionally, circulating sEV miRNAs remained constant after different treatments, and the addition of the CirsEV-miR classifier as a biomarker improves the current surgical strategy.The CirsEV-miR classifier could serve as a noninvasive, convenient, specific and stable auxiliary test to help diagnose FTC following ultrasonography.
rights: © 2024. The Author(s), under exclusive licence to Springer Nature Limited.
has PII: 10.1038/s41416-024-02575-0
doi: 10.1038/s41416-024-02575-0
creator: OrderedList
  length: 18
  slot:
    index: 1
    item: Li G
      type: Person
      first name: Genpeng
      last name: Li
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 2
    item: Wang H
      type: Person
      first name: Hongke
      last name: Wang
      member of: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  slot:
    index: 3
    item: Zhong J
      type: Person
      first name: Jinjing
      last name: Zhong
      member of: Department of Pathology, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 4
    item: Bai Y
      type: Person
      first name: Yilan
      last name: Bai
      member of: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  slot:
    index: 5
    item: Chen W
      type: Person
      first name: Wenjie
      last name: Chen
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 6
    item: Jiang K
      type: Person
      first name: Ke
      last name: Jiang
      member of: Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
  slot:
    index: 7
    item: Huang J
      type: Person
      first name: Jing
      last name: Huang
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 8
    item: Shao Y
      type: Person
      first name: Yuting
      last name: Shao
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 9
    item: Liu J
      type: Person
      first name: Jiaye
      last name: Liu
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 10
    item: Gong Y
      type: Person
      first name: Yanping
      last name: Gong
      member of: Thyroid Surgery, West China Tianfu Hospital, Chengdu, China.
  slot:
    index: 11
    item: Zhang J
      type: Person
      first name: Junhui
      last name: Zhang
      member of: Thyroid and Breast Surgery, West China Fourth Hospital, Chengdu, China.
  slot:
    index: 12
    item: Sun R
      type: Person
      first name: Ronghao
      last name: Sun
      member of: Department of Head and Neck Surgery, Sichuan Provincial Cancer Hospital, Chengdu, China.
  slot:
    index: 13
    item: Wei T
      type: Person
      first name: Tao
      last name: Wei
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 14
    item: Gong R
      type: Person
      first name: Rixiang
      last name: Gong
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 15
    item: Zhu J
      type: Person
      first name: Jingqiang
      last name: Zhu
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 16
    item: Lu Z
      type: Person
      first name: Zhi
      last name: Lu
      member of: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.
  slot:
    index: 17
    item: Li Z
      type: Person
      first name: Zhihui
      last name: Li
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China.
  slot:
    index: 18
    item: Lei J
      type: Person
      first name: Jianyong
      last name: Lei
      member of: Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China. leijianyong@scu.edu.cn.The Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China. leijianyong@scu.edu.cn.
created: 2024-1-19T00:42
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 Apr
created: 2024-1-18T23:21
e ISSN: 1532-1827
has issn l: 0007-0920
issue: 6
has NLM journal title abbreviation: Br J Cancer
publication name: British journal of cancer
language: eng
has national library of medicine journal id: 0370635
derived from: NLM
starting page: 925
ending page: 933
has place of publication: England
has primary subject term: D035683Q000235Q000378
has primary subject term: D018263Q000175Q000235Q000378
has primary subject term: D000067128Q000378
has primary subject term: D013964Q000175Q000235Q000378
has subject term: D006801
has subject term: D015415
source: Br J Cancer. 2024-04;130(6):925-933.
volume: 130

Molecular detection of Paracoccidioides spp. in environmental samples from the Southwestern Amazon.
pmid: 38238556
abstract: Paracoccidioidomycosis is an infection with the potential for environmental dissemination, especially in regions of hot and humid climate, where human cases have been recorded in the Southwestern Amazon of Brazil, specifically in the state of Acre. Despite studies providing information about the presence of these fungi in soil and animal samples, such as armadillos, further investigations are still needed to determine the epidemiological distribution of the genus Paracoccidioides. The aim of this study was to detect the occurrence of Paracoccidioides fungi in the Southwestern Amazon. To achieve this, 60 soil samples were collected from armadillo burrows on rural properties in the in the municipalities of Acrelândia, Bujari, Plácido de Castro, Rio Branco, Sena Madureira, and Senador Guiomard, located in the state of Acre, Brazil. Fungal DNA was extracted from these samples using the DNEASY® PowerSoil kit-Quiagen, followed by Nested PCR technique with ITS4 and ITS5 as external primers, and PBITS-E and PBITS-R as internal primers. DNA amplification products of about 380 bp compatible with Paracoccidioides spp. were detected in six samples (10%), being sequenced and identified as P. brasiliensis. These findings indicate that the soils of the Acre state could be considered a potential source for Paracoccidioides spp., suggesting that local infections are likely.
rights: © 2024. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.
has PII: 10.1007/s42770-024-01256-7
doi: 10.1007/s42770-024-01256-7
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Ferreira IRS
      type: Person
      first name: Iasminy R Silva
      last name: Ferreira
      member of: Graduate Program in Biodiversity and Biotechnology, Federal University of Acre, Rio Branco, AC, 69920-900, Brazil. Iasminysf@gmail.com.
  slot:
    index: 2
    item: de M Teixeira M
      type: Person
      first name: Marcus
      last name: de M Teixeira
      member of: Tropical Medicine Center, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília, DF, 70910-900, Brazil.
  slot:
    index: 3
    item: de Araújo AV
      type: Person
      first name: Atilon V
      last name: de Araújo
      member of: Graduate Program in Biodiversity and Biotechnology, Federal University of Acre, Rio Branco, AC, 69920-900, Brazil.
  slot:
    index: 4
    item: Bagagli E
      type: Person
      first name: Eduardo
      last name: Bagagli
      member of: Department of Chemical and Biological Sciences, São Paulo State University Júlio de Mesquita Filho , Botucatu, SP, 18618-687, Brazil.
  slot:
    index: 5
    item: Garces HG
      type: Person
      first name: Hans G
      last name: Garces
      member of: Department of Chemical and Biological Sciences, São Paulo State University Júlio de Mesquita Filho , Botucatu, SP, 18618-687, Brazil.
  slot:
    index: 6
    item: Peters LP
      type: Person
      first name: Leila P
      last name: Peters
      member of: Center for Biological and Natural Sciences, Federal University of Acre, Rio Branco, AC, 69920-900, Brazil.
  slot:
    index: 7
    item: Carvalho CM
      type: Person
      first name: Clarice M
      last name: Carvalho
      member of: Graduate Program in Biodiversity and Biotechnology, Federal University of Acre, Rio Branco, AC, 69920-900, Brazil.Center for Biological and Natural Sciences, Federal University of Acre, Rio Branco, AC, 69920-900, Brazil.
created: 2024-1-19T00:42
date last updated: 2025-01-20
issued: 2024-03
dp: 2024 Mar
created: 2024-1-18T23:27
e ISSN: 1678-4405
has issn l: 1517-8382
issue: 1
has NLM journal title abbreviation: Braz J Microbiol
publication name: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
language: eng
has national library of medicine journal id: 101095924
derived from: NLM
starting page: 837
ending page: 842
has place of publication: Brazil
has primary subject term: D010228Q000235
has primary subject term: D010229Q000453Q000382
has subject term: D000818
has subject term: D006801
has subject term: D012988
has subject term: D005658
has subject term: D012987
has subject term: D001938Q000453
source: Braz J Microbiol. 2024-03;55(1):837-842.
volume: 55

Poly(glutamic acid)-Based Viscosity Reducers for Concentrated Formulations of a Monoclonal IgG Antibody.
pmid: 38240032
abstract: Above a concentration threshold, the viscosity of solutions of proteins increases abruptly, which hampers the injectability of therapeutic formulations. Concentrations above 200 g/L are an ideal goal for subcutaneous application of antibodies. Molecular additives, such as amino acids (e.g., arginine) help decrease the viscosity, but they are used at concentrations as high as about 200 mmol/L. We addressed the question of whether poly(amino acids) could be more efficient than small molecular additives. We observed marked fluidification of a model therapeutic monoclonal antibody (mAb) solution by poly(d,l-glutamic acid) and poly(l-glutamic acid) derivatives added at concentrations of <6.5 g/L (i.e., a mAb/polymer chain molar ratio between 4:1 and 1:1 mol/mol). The bare poly(glutamate) parent chains were compared with polyethylene glycol-grafted chains as PEGylation is a common way to enhance stability. Viscosity could be decreased to ∼20 mPa s as compared to values of ∼100 mPa s in the absence of polymers at 200 g/L mAb. Formation of complexes between the mAb and the polyglutamates was characterized by capillary electrophoresis analysis in dilute solutions (1 g/L mAb) and by observation of phase separation at higher concentrations, suggesting tight association at about 2:1 mol/mol mAb/polymer. Altogether, these results show that polyglutamate derivatives hold an untapped potential as an excipient for fluidification of concentrated protein solutions.
doi: 10.1021/acs.molpharmaceut.3c01159
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Lapenna A
      type: Person
      first name: Annamaria
      last name: Lapenna
      member of: Département de Chimie, PASTEUR, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, Paris 75005, France.
  slot:
    index: 2
    item: Dagallier C
      type: Person
      first name: Camille
      last name: Dagallier
      member of: Biologics Formulation & Process Development, Biologics Drug Product Development Department, SANOFI R&D, 13 quai Jules Guesde- BP 14, Vitry-sur-Seine 94403, France.
  slot:
    index: 3
    item: Huille S
      type: Person
      first name: Sylvain
      last name: Huille
      member of: Biologics Formulation & Process Development, Biologics Drug Product Development Department, SANOFI R&D, 13 quai Jules Guesde- BP 14, Vitry-sur-Seine 94403, France.
  slot:
    index: 4
    item: Tribet C
      type: Person
      first name: Christophe
      last name: Tribet
      member of: Département de Chimie, PASTEUR, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, Paris 75005, France.
created: 2024-1-19T06:42
date last updated: 2025-01-20
issued: 2024-02-05
dp: 2024 Feb 05
created: 2024-1-19T03:54
e ISSN: 1543-8392
has issn l: 1543-8384
issue: 2
has NLM journal title abbreviation: Mol Pharm
publication name: Molecular pharmaceutics
language: eng
has national library of medicine journal id: 101197791
derived from: NLM
starting page: 982
ending page: 991
has place of publication: United States
has primary subject term: D000911Q000737
has primary subject term: D018698
has subject term: D014783
has subject term: D007074Q000737
has subject term: D000596Q000737
has subject term: D011108
source: Mol Pharm. 2024-02-05;21(2):982-991.
volume: 21

Overcoming barriers and stigma: new frontiers in solid organ transplantation for people with HIV.
pmid: 38240603
abstract: There is a growing need for solid organ transplantation (SOT) for people living with human immunodeficiency virus (HIV). With the advent of antiretroviral therapy, people living with HIV are experiencing increased life expectancies and are, therefore, developing more comorbidities, including end-stage organ disease. In cases of advanced organ failure, SOT is often the best therapeutic option to improve quality of life and overall survival. As organ shortages persist, transplantation of organs from donors with HIV to recipients with HIV has become a potential therapeutic option. This article first reviews the current state of organ transplantation from donors without HIV to recipients with HIV (HIV D-/R+) by organ and discusses key lessons learned from these transplant trials, including those about drug-drug interactions, rejection, and opportunistic infections. It then explores transplantation from donors with HIV to recipients with HIV (HIV D+/R+), a new frontier. Finally, it investigates challenges of implementation, including public awareness and regulatory requirements, and explores future directions for SOT in people living with HIV.
doi: 10.1128/cmr.00111-22
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Storm K
      type: Person
      first name: K
      last name: Storm
      member of: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  slot:
    index: 2
    item: Durand CM
      type: Person
      first name: C M
      last name: Durand
      member of: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
created: 2024-1-19T12:44
date last updated: 2025-01-20
issued: 2024-03-14
dp: 2024 03 14
created: 2024-1-19T09:23
e ISSN: 1098-6618
has issn l: 0893-8512
issue: 1
has NLM journal title abbreviation: Clin Microbiol Rev
publication name: Clinical microbiology reviews
language: eng
has national library of medicine journal id: 8807282
derived from: NLM
pg: e0011122
has place of publication: United States
has primary subject term: D016377
has primary subject term: D015658Q000188
has subject term: D006801
has subject term: D006678
has subject term: D011788
has subject term: D014019
source: Clin Microbiol Rev. 2024-03-14;37(1):e0011122.
volume: 37

Microsurgical Clipping of Unruptured Anterior Circulation Aneurysms-A Global Multicenter Investigation of Perioperative Outcomes.
pmid: 38240568
abstract: Microsurgical aneurysm repair by clipping continues to be highly important despite increasing endovascular treatment options, especially because of inferior occlusion rates. This study aimed to present current global microsurgical treatment practices and to identify risk factors for complications and neurological deterioration after clipping of unruptured anterior circulation aneurysms.Fifteen centers from 4 continents participated in this retrospective cohort study. Consecutive patients who underwent elective microsurgical clipping of untreated unruptured intracranial aneurysm between January 2016 and December 2020 were included. Posterior circulation aneurysms were excluded. Outcome parameters were postsurgical complications and neurological deterioration (defined as decline on the modified Rankin Scale) at discharge and during follow-up. Multivariate regression analyses were performed adjusting for all described patient characteristics.Among a total of 2192 patients with anterior circulation aneurysm, complete occlusion of the treated aneurysm was achieved in 2089 (95.3%) patients at discharge. The occlusion rate remained stable (94.7%) during follow-up. Regression analysis identified hypertension (P < .02), aneurysm diameter (P < .001), neck diameter (P < .05), calcification (P < .01), and morphology (P = .002) as preexisting risk factors for postsurgical complications and neurological deterioration at discharge. Furthermore, intraoperative aneurysm rupture (odds ratio 2.863 [CI 1.606-5.104]; P < .01) and simultaneous clipping of more than 1 aneurysm (odds ratio 1.738 [CI 1.186-2.545]; P < .01) were shown to be associated with an increased risk of postsurgical complications. Yet, none of the surgical-related parameters had an impact on neurological deterioration. Analyzing volume-outcome relationship revealed comparable complication rates (P = .61) among all 15 participating centers.Our international, multicenter analysis presents current microsurgical treatment[cell cut: 2309 characters, first 2000 kept]
rights: Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Congress of Neurological Surgeons.
has PII: 00006123-990000000-01023
doi: 10.1227/neu.0000000000002829
creator: OrderedList
  length: 47
  slot:
    index: 1
    item: Sauvigny J
      type: Person
      first name: Jennifer
      last name: Sauvigny
      member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 2
    item: Drexler R
      type: Person
      first name: Richard
      last name: Drexler
      member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 3
    item: Pantel TF
      type: Person
      first name: Tobias F
      last name: Pantel
      member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 4
    item: Ricklefs FL
      type: Person
      first name: Franz L
      last name: Ricklefs
      member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  slot:
    index: 5
    item: Catapano JS
      type: Person
      first name: Joshua S
      last name: Catapano
      member of: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
  slot:
    index: 6
    item: Wanebo JE
      type: Person
      first name: John E
      last name: Wanebo
      member of: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
  slot:
    index: 7
    item: Lawton MT
      type: Person
      first name: Michael T
      last name: Lawton
      member of: Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
  slot:
    index: 8
    item: Sanchin A
      type: Person
      first name: Aminaa
      last name: Sanchin
      member of: Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  slot:
    index: 9
    item: Hecht N
      type: Person
      first name: Nils
      last name: Hecht
      member of: Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  slot:
    index: 10
    item: Vajkoczy P
      type: Person
      first name: Peter
      last name: Vajkoczy
      member of: Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  slot:
    index: 11
    item: Raygor K
      type: Person
      first name: Kunal
      last name: Raygor
      member of: Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  slot:
    index: 12
    item: Tonetti D
      type: Person
      first name: Daniel
      last name: Tonetti
      member of: Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  slot:
    index: 13
    item: Abla A
      type: Person
      first name: Adib
      last name: Abla
      member of: Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
  slot:
    index: 14
    item: El Naamani K
      type: Person
      first name: Kareem
      last name: El Naamani
      member of: Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
  slot:
    index: 15
    item: Tjoumakaris SI
      type: Person
      first name: Stavropoula I
      last name: Tjoumakaris
      member of: Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
  slot:
    index: 16
    item: Jabbour P
      type: Person
      first name: Pascal
      last name: Jabbour
      member of: Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
  slot:
    index: 17
    item: Jankowitz BT
      type: Person
      first name: Brian T
      last name: Jankowitz
      member of: Department of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.
  slot:
    index: 18
    item: Salem MM
      type: Person
      first name: Mohamed M
      last name: Salem
      member of: Department of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.
  slot:
    index: 19
    item: Burkhardt JK
      type: Person
      first name: Jan-Karl
      last name: Burkhardt
      member of: Department of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.
  slot:
    index: 20
    item: Wagner A
      type: Person
      first name: Arthur
      last name: Wagner
      member of: Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
  slot:
    index: 21
    item: Wostrack M
      type: Person
      first name: Maria
      last name: Wostrack
      member of: Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
  slot:
    index: 22
    item: Gempt J
      type: Person
      first name: Jens
      last name: Gempt
      member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
  slot:
    index: 23
    item: Meyer B
      type: Person
      first name: Bernhard
      last name: Meyer
      member of: Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
  slot:
    index: 24
    item: Gaub M
      type: Person
      first name: Michael
      last name: Gaub
      member of: Department of Neurosurgery, University of Texas Health and Science Center at San Antonio, San Antonio, Texas, USA.
  slot:
    index: 25
    item: Mascitelli JR
      type: Person
      first name: Justin R
      last name: Mascitelli
      member of: Department of Neurosurgery, University of Texas Health and Science Center at San Antonio, San Antonio, Texas, USA.
  slot:
    index: 26
    item: Dodier P
      type: Person
      first name: Philippe
      last name: Dodier
      member of: Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 27
    item: Bavinzski G
      type: Person
      first name: Gerhard
      last name: Bavinzski
      member of: Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
  slot:
    index: 28
    item: Roessler K
      type: Person
      first name: Karl
      last name: Roessler
      member of: Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
created: 2024-1-19T12:43
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 Jan 19
created: 2024-1-19T09:03
e ISSN: 1524-4040
has issn l: 0148-396X
has NLM journal title abbreviation: Neurosurgery
publication name: Neurosurgery
language: eng
has national library of medicine journal id: 7802914
derived from: NLM
has place of publication: United States
source: Neurosurgery. 2024-01-19;():.

Hfe Permease and Haemophilus influenzae Manganese Homeostasis.
pmid: 38240689
abstract: Haemophilus influenzae is a commensal of the human upper respiratory tract that can infect diverse host niches due, at least in part, to its ability to withstand both endogenous and host-mediated oxidative stresses. Here, we show that hfeA, a gene previously linked to iron import, is essential for H. influenzae manganese recruitment via the HfeBCD transporter. Structural analyses show that metal binding in HfeA uses a unique mechanism that involves substantial rotation of the C-terminal lobe of the protein. Disruption of hfeA reduced H. influenzae manganese acquisition and was associated with decreased growth under aerobic conditions, impaired manganese-superoxide dismutase activity, reduced survival in macrophages, and changes in biofilm production in the presence of superoxide. Collectively, this work shows that HfeA contributes to H. influenzae manganese acquisition and virulence attributes. High conservation of the hfeABCD permease in Haemophilus species suggests that it may serve similar roles in other pathogenic Pasteurellaceae.
doi: 10.1021/acsinfecdis.3c00407
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Ganio K
      type: Person
      first name: Katherine
      last name: Ganio
      member of: Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
  slot:
    index: 2
    item: Nasreen M
      type: Person
      first name: Marufa
      last name: Nasreen
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 3
    item: Yang Z
      type: Person
      first name: Zihao
      last name: Yang
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 4
    item: Maunders EA
      type: Person
      first name: Eve A
      last name: Maunders
      member of: Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
  slot:
    index: 5
    item: Luo Z
      type: Person
      first name: Zhenyao
      last name: Luo
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 6
    item: Hossain SI
      type: Person
      first name: Sheikh Imamul
      last name: Hossain
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.School of Life Sciences, University of Technology Sydney, Ultimo, New South Wales 2007, Australia.
  slot:
    index: 7
    item: Ngu DHY
      type: Person
      first name: Dalton H Y
      last name: Ngu
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 8
    item: Ellis D
      type: Person
      first name: Daniel
      last name: Ellis
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 9
    item: Gu J
      type: Person
      first name: Jin
      last name: Gu
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 10
    item: Neville SL
      type: Person
      first name: Stephanie L
      last name: Neville
      member of: Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
  slot:
    index: 11
    item: Wilksch J
      type: Person
      first name: Jonathan
      last name: Wilksch
      member of: Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
  slot:
    index: 12
    item: Gunn AP
      type: Person
      first name: Adam P
      last name: Gunn
      member of: Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
  slot:
    index: 13
    item: Whittall JJ
      type: Person
      first name: Jonathan J
      last name: Whittall
      member of: School of Biological Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.
  slot:
    index: 14
    item: Kobe B
      type: Person
      first name: Boštjan
      last name: Kobe
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 15
    item: Deplazes E
      type: Person
      first name: Evelyne
      last name: Deplazes
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.School of Life Sciences, University of Technology Sydney, Ultimo, New South Wales 2007, Australia.
  slot:
    index: 16
    item: Kappler U
      type: Person
      first name: Ulrike
      last name: Kappler
      member of: School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia.Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland 4072, Australia.
  slot:
    index: 17
    item: McDevitt CA
      type: Person
      first name: Christopher A
      last name: McDevitt
      member of: Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
created: 2024-1-19T12:43
date last updated: 2025-01-20
issued: 2024-02-09
dp: 2024 02 09
created: 2024-1-19T10:13
e ISSN: 2373-8227
has issn l: 2373-8227
issue: 2
has NLM journal title abbreviation: ACS Infect Dis
publication name: ACS infectious diseases
language: eng
has national library of medicine journal id: 101654580
derived from: NLM
starting page: 436
ending page: 452
has place of publication: United States
has primary subject term: D006193Q000235Q000378
has primary subject term: D026901Q000235
has subject term: D006801
has subject term: D008345Q000378
has subject term: D018441
has subject term: D006706
source: ACS Infect Dis. 2024-02-09;10(2):436-452.
volume: 10

Structural barriers to health care as risk factors for preterm and small-for-gestational-age birth among US-born Black and White mothers.
pmid: 38241851
abstract: We develop county-level measures of structural and institutional barriers to care, and test associations between these barriers and birth outcomes for US-born Black and White mothers using national birth records for 2014-2017. Results indicate elevated odds of greater preterm birth severity for Black mothers in counties with higher uninsurance rates among Black adults, fewer Black physicians per Black residents, and fewer publicly-funded contraceptive services. Most structural barriers were not associated with small-for-gestational-age birth, and barriers defined for Black residents were not associated with birth outcomes for White mothers, with the exception of Black uninsurance rate. Structural determinants of care may influence preterm birth risk for Black Americans.
rights: Copyright © 2024 Elsevier Ltd. All rights reserved.
has PII: S1353-8292(24)00005-4
doi: 10.1016/j.healthplace.2024.103177
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Curtis DS
      type: Person
      first name: David S
      last name: Curtis
      member of: Department of Family and Consumer Studies, University of Utah, Salt Lake City, UT, 84112, USA. Electronic address: david.curtis@fcs.utah.edu.
  slot:
    index: 2
    item: Waitzman N
      type: Person
      first name: Norman
      last name: Waitzman
      member of: Department of Economics, University of Utah, Salt Lake City, UT, 84112, USA.
  slot:
    index: 3
    item: Kramer MR
      type: Person
      first name: Michael R
      last name: Kramer
      member of: Department of Epidemiology, Emory University, Atlanta, GA, 30322, USA.
  slot:
    index: 4
    item: Shakib JH
      type: Person
      first name: Julie H
      last name: Shakib
      member of: Department of Pediatrics, University of Utah, Salt Lake City, UT, 84112, USA.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-01
dp: 2024 Jan
created: 2024-1-19T18:07
e ISSN: 1873-2054
has issn l: 1353-8292
has NLM journal title abbreviation: Health Place
publication name: Health & place
language: eng
has national library of medicine journal id: 9510067
derived from: NLM
pg: 103177
has place of publication: England
has primary subject term: D047928Q000453
has primary subject term: D007236
has subject term: D000328
has subject term: D005260
has subject term: D006801
has subject term: D007231
has subject term: D003695
has subject term: D012307
has subject term: http://id.nlm.nih.gov/mesh/D000095223
has subject term: D001741
has subject term: D017057
source: Health Place. 2024-01;85():103177.
volume: 85

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective.
pmid: 38242087
abstract: Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection to acquire samples representing the whole tumor mapped by 3D spatial coordinates. Integrative tissue and single-cell analysis revealed sources of genomic, epigenomic, and microenvironmental intratumoral heterogeneity and their spatial patterning. By distinguishing tumor-wide molecular features from those with regional specificity, we inferred GBM evolutionary trajectories from neurodevelopmental lineage origins and initiating events such as chromothripsis to emergence of genetic subclones and spatially restricted activation of differential tumor and microenvironmental programs in the core, periphery, and contrast-enhancing regions. Our work depicts GBM evolution and heterogeneity from a 3D whole-tumor perspective, highlights potential therapeutic targets that might circumvent heterogeneity-related failures, and establishes an interactive platform enabling 360° visualization and analysis of 3D spatial patterns for user-selected genes, programs, and other features across whole GBM tumors.
rights: Copyright © 2023. Published by Elsevier Inc.
has PII: S0092-8674(23)01345-4
doi: 10.1016/j.cell.2023.12.013
creator: OrderedList
  length: 30
  slot:
    index: 1
    item: Mathur R
      type: Person
      first name: Radhika
      last name: Mathur
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 2
    item: Wang Q
      type: Person
      first name: Qixuan
      last name: Wang
      member of: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 3
    item: Schupp PG
      type: Person
      first name: Patrick G
      last name: Schupp
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 4
    item: Nikolic A
      type: Person
      first name: Ana
      last name: Nikolic
      member of: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB.
  slot:
    index: 5
    item: Hilz S
      type: Person
      first name: Stephanie
      last name: Hilz
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 6
    item: Hong C
      type: Person
      first name: Chibo
      last name: Hong
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 7
    item: Grishanina NR
      type: Person
      first name: Nadia R
      last name: Grishanina
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 8
    item: Kwok D
      type: Person
      first name: Darwin
      last name: Kwok
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 9
    item: Stevers NO
      type: Person
      first name: Nicholas O
      last name: Stevers
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 10
    item: Jin Q
      type: Person
      first name: Qiushi
      last name: Jin
      member of: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 11
    item: Youngblood MW
      type: Person
      first name: Mark W
      last name: Youngblood
      member of: Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 12
    item: Stasiak LA
      type: Person
      first name: Lena Ann
      last name: Stasiak
      member of: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 13
    item: Hou Y
      type: Person
      first name: Ye
      last name: Hou
      member of: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 14
    item: Wang J
      type: Person
      first name: Juan
      last name: Wang
      member of: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 15
    item: Yamaguchi TN
      type: Person
      first name: Takafumi N
      last name: Yamaguchi
      member of: Department of Human Genetics, University of California, Los Angeles, Los Angees, CA, USA.
  slot:
    index: 16
    item: Lafontaine M
      type: Person
      first name: Marisa
      last name: Lafontaine
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 17
    item: Shai A
      type: Person
      first name: Anny
      last name: Shai
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 18
    item: Smirnov IV
      type: Person
      first name: Ivan V
      last name: Smirnov
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 19
    item: Solomon DA
      type: Person
      first name: David A
      last name: Solomon
      member of: Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 20
    item: Chang SM
      type: Person
      first name: Susan M
      last name: Chang
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 21
    item: Hervey-Jumper SL
      type: Person
      first name: Shawn L
      last name: Hervey-Jumper
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 22
    item: Berger MS
      type: Person
      first name: Mitchel S
      last name: Berger
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 23
    item: Lupo JM
      type: Person
      first name: Janine M
      last name: Lupo
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 24
    item: Okada H
      type: Person
      first name: Hideho
      last name: Okada
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 25
    item: Phillips JJ
      type: Person
      first name: Joanna J
      last name: Phillips
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
  slot:
    index: 26
    item: Boutros PC
      type: Person
      first name: Paul C
      last name: Boutros
      member of: Department of Human Genetics, University of California, Los Angeles, Los Angees, CA, USA.
  slot:
    index: 27
    item: Gallo M
      type: Person
      first name: Marco
      last name: Gallo
      member of: Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB; Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
  slot:
    index: 28
    item: Oldham MC
      type: Person
      first name: Michael C
      last name: Oldham
      member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-01-18
dp: 2024 01 18
created: 2024-1-19T18:18
e ISSN: 1097-4172
has issn l: 0092-8674
issue: 2
has NLM journal title abbreviation: Cell
publication name: Cell
language: eng
has national library of medicine journal id: 0413066
derived from: NLM
starting page: 446
ending page: 463.e16
has place of publication: United States
has primary subject term: D001932Q000235Q000473
has primary subject term: D005909Q000235Q000473
has primary subject term: D008954
has subject term: D006801
has subject term: D057890
has subject term: D023281
has subject term: D059010
has subject term: D059016
has subject term: D018740
source: Cell. 2024-01-18;187(2):446-463.e16.
volume: 187

A dispensable role of oligodendrocyte-derived laminin-α5 in brain homeostasis and intracerebral hemorrhage.
pmid: 38241459
abstract: Laminin, a major component of the basal lamina in the CNS, is also expressed in oligodendrocytes (OLs). However, the function of OL-derived laminin remains largely unknown. Here, we performed loss-of-function studies using two OL-specific laminin-α5 conditional knockout mouse lines. Both mutants were grossly normal and displayed intact blood-brain barrier (BBB) integrity. In a mouse model of intracerebral hemorrhage (ICH), control mice and both mutants exhibited comparable hematoma size and neurological dysfunction. In addition, similar levels of hemoglobin and IgG leakage were detected in the mutant brains compared to the controls, indicating comparable BBB damage. Consistent with this finding, subsequent studies revealed no differences in tight junction protein (TJP) and caveolin-1 expression among control and knockout mice, suggesting that neither paracellular nor transcellular mechanism was affected in the mutants. Furthermore, compared to the controls, both mutant lines showed comparable oligodendrocyte number, oligodendrocyte proliferation rate, MBP/MAG levels, and SMI-32 expression, highlighting a minimal role of OL-derived laminin-α5 in OL biology. Together, these findings highlight a dispensable role of OL-derived laminin-α5 in both brain homeostasis and ICH pathogenesis.
doi: 10.1177/0271678X241228058
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Kang M
      type: Person
      first name: Minkyung
      last name: Kang
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  slot:
    index: 2
    item: Nirwane A
      type: Person
      first name: Abhijit
      last name: Nirwane
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  slot:
    index: 3
    item: Ruan J
      type: Person
      first name: Jingsong
      last name: Ruan
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  slot:
    index: 4
    item: Adithan A
      type: Person
      first name: Aravinthan
      last name: Adithan
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  slot:
    index: 5
    item: Gray M
      type: Person
      first name: Marsilla
      last name: Gray
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  slot:
    index: 6
    item: Xu L
      type: Person
      first name: Lingling
      last name: Xu
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.Current Address: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
  slot:
    index: 7
    item: Yao Y
      type: Person
      first name: Yao
      last name: Yao
      member of: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
created: 2024-1-19T18:30
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 04
created: 2024-1-19T14:32
e ISSN: 1559-7016
has issn l: 0271-678X
issue: 4
has NLM journal title abbreviation: J Cereb Blood Flow Metab
publication name: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
language: eng
has national library of medicine journal id: 8112566
derived from: NLM
starting page: 611
ending page: 623
has place of publication: United States
has primary subject term: D001812Q000378
has primary subject term: D001921Q000378
has subject term: D000818
has subject term: D051379
has subject term: D002543Q000473
has subject term: D006706
has subject term: D007797Q000378
has subject term: D018345
has subject term: D009836Q000378
source: J Cereb Blood Flow Metab. 2024-04;44(4):611-623.
volume: 44

Cannabis Use Associates With Reduced Proviral Burden and Inflammatory Cytokine in Tissues From Men With Clade C HIV-1 on Suppressive Antiretroviral Therapy.
pmid: 38243412
abstract: Human immunodeficiency virus 1 (HIV-1) tissue reservoirs remain the main obstacle against an HIV cure. Limited information exists regarding cannabis's effects on HIV-1 infections in vivo, and the impact of cannabis use on HIV-1 parenchymal tissue reservoirs is unexplored.To investigate whether cannabis use alters HIV-1 tissue reservoirs, we systematically collected 21 postmortem brain and peripheral tissues from 20 men with subtype C HIV-1 and with suppressed viral load enrolled in Zambia, 10 of whom tested positive for cannabis use. The tissue distribution and copies of subtype C HIV-1 LTR, gag, env DNA and RNA, and the relative mRNA levels of cytokines IL-1β, IL-6, IL-10, and TGF-β1 were quantified using PCR-based approaches. Utilizing generalized linear mixed models we compared persons with HIV-1 and suppressed viral load, with and without cannabis use.The odds of tissues harboring HIV-1 DNA and the viral DNA copies in those tissues were significantly lower in persons using cannabis. Moreover, the transcription levels of proinflammatory cytokines IL-1β and IL-6 in lymphoid tissues of persons using cannabis were also significantly lower.Our findings suggested that cannabis use is associated with reduced sizes and inflammatory cytokine expression of subtype C HIV-1 reservoirs in men with suppressed viral load.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577694
doi: 10.1093/infdis/jiad575
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Liu Z
      type: Person
      first name: Zhou
      last name: Liu
      member of: School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.Department of Interdisciplinary Oncology, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center,New Orleans, Louisiana, USA.
  slot:
    index: 2
    item: Julius P
      type: Person
      first name: Peter
      last name: Julius
      member of: Department of Pathology and Microbiology, University of Zambia School of Medicine, Lusaka, Zambia.
  slot:
    index: 3
    item: Himwaze CM
      type: Person
      first name: Cordilia Maria
      last name: Himwaze
      member of: Department of Pathology and Microbiology, University of Zambia School of Medicine, Lusaka, Zambia.
  slot:
    index: 4
    item: Mucheleng'anga LA
      type: Person
      first name: Luchenga Adam
      last name: Mucheleng'anga
      member of: Office of the State Forensic Pathologist, Ministry of Home Affairs, Lusaka, Zambia.
  slot:
    index: 5
    item: Chapple AG
      type: Person
      first name: Andrew G
      last name: Chapple
      member of: Department of Interdisciplinary Oncology, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center,New Orleans, Louisiana, USA.
  slot:
    index: 6
    item: West JT
      type: Person
      first name: John T
      last name: West
      member of: Department of Interdisciplinary Oncology, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center,New Orleans, Louisiana, USA.
  slot:
    index: 7
    item: Wood C
      type: Person
      first name: Charles
      last name: Wood
      member of: School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.Department of Interdisciplinary Oncology, Louisiana Cancer Research Center, Louisiana State University Health Sciences Center,New Orleans, Louisiana, USA.
created: 2024-1-20T10:42
date last updated: 2025-01-20
issued: 2024-05-15
dp: 2024 May 15
created: 2024-1-20T00:53
e ISSN: 1537-6613
has issn l: 0022-1899
issue: 5
has NLM journal title abbreviation: J Infect Dis
publication name: The Journal of infectious diseases
language: eng
has national library of medicine journal id: 0413675
derived from: NLM
starting page: 1306
ending page: 1316
has place of publication: United States
has primary subject term: D015497Q000235Q000187
has primary subject term: D015658Q000188Q000821
has primary subject term: D016207Q000378Q000235
has primary subject term: D019562
has subject term: D006801
has subject term: D008297
has subject term: D000328
has subject term: D011533Q000235
has subject term: D008875
has subject term: D015024
has subject term: D004279
has subject term: D044966Q000627
has subject term: D001921Q000821Q000378
has subject term: D055815
has subject term: D000074609Q000378
source: J Infect Dis. 2024-05-15;229(5):1306-1316.
volume: 229

Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV-2 2'-O-Methyltransferase.
pmid: 38242544
abstract: The urgent need for new classes of orally available, safe, and effective antivirals─covering a breadth of emerging viruses─is evidenced by the loss of life and economic challenges created by the HIV-1 and SARS-CoV-2 pandemics. As frontline interventions, small-molecule antivirals can be deployed prophylactically or postinfection to control the initial spread of outbreaks by reducing transmissibility and symptom severity. Natural products have an impressive track record of success as prototypic antivirals and continue to provide new drugs through synthesis, medicinal chemistry, and optimization decades after discovery. Here, we demonstrate an approach using computational analysis typically used for rational drug design to identify and develop natural product-inspired antivirals. This was done with the goal of identifying natural product prototypes to aid the effort of progressing toward safe, effective, and affordable broad-spectrum inhibitors of Betacoronavirus replication by targeting the highly conserved RNA 2'-O-methyltransferase (2'-O-MTase). Machaeriols RS-1 (7) and RS-2 (8) were identified using a previously outlined informatics approach to first screen for natural product prototypes, followed by in silico-guided synthesis. Both molecules are based on a rare natural product group. The machaeriols (3-6), isolated from the genus Machaerium, endemic to Amazonia, inhibited the SARS-CoV-2 2'-O-MTase more potently than the positive control, Sinefungin (2), and in silico modeling suggests distinct molecular interactions. This report highlights the potential of computationally driven screening to leverage natural product libraries and improve the efficiency of isolation or synthetic analog development.
doi: 10.1021/acs.jnatprod.3c00875
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Hanna GS
      type: Person
      first name: George S
      last name: Hanna
      member of: Department of Drug Discovery, Biomedical Sciences and Public Health, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
  slot:
    index: 2
    item: Benjamin MM
      type: Person
      first name: Menny M
      last name: Benjamin
      member of: Department of Drug Discovery, Biomedical Sciences and Public Health, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
  slot:
    index: 3
    item: Choo YM
      type: Person
      first name: Yeun-Mun
      last name: Choo
      member of: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  slot:
    index: 4
    item: De R
      type: Person
      first name: Ramyani
      last name: De
      member of: Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive, NE Atlanta, Georgia 30322, United States.
  slot:
    index: 5
    item: Schinazi RF
      type: Person
      first name: Raymond F
      last name: Schinazi
      member of: Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive, NE Atlanta, Georgia 30322, United States.
  slot:
    index: 6
    item: Nielson SE
      type: Person
      first name: Sarah E
      last name: Nielson
      member of: Department of Chemistry & Biochemistry, Utah State University, Logan, Utah 84322, United States.
  slot:
    index: 7
    item: Hevel JM
      type: Person
      first name: Joan M
      last name: Hevel
      member of: Department of Chemistry & Biochemistry, Utah State University, Logan, Utah 84322, United States.
  slot:
    index: 8
    item: Hamann MT
      type: Person
      first name: Mark T
      last name: Hamann
      member of: Department of Drug Discovery, Biomedical Sciences and Public Health, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-02-23
dp: 2024 02 23
created: 2024-1-19T19:53
e ISSN: 1520-6025
has issn l: 0163-3864
issue: 2
has NLM journal title abbreviation: J Nat Prod
publication name: Journal of natural products
language: eng
has national library of medicine journal id: 7906882
derived from: NLM
starting page: 217
ending page: 227
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000086382
has primary subject term: D001688Q000494
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000086402
has subject term: D048088
has subject term: D000998Q000494
source: J Nat Prod. 2024-02-23;87(2):217-227.
volume: 87

Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer: a multicentre external validation in patients who underwent surgery.
pmid: 38243011
abstract: Several diagnostic prediction models to help clinicians discriminate between benign and malignant adnexal masses are available. This study is a head-to-head comparison of the performance of the Assessment of Different NEoplasias in the adneXa (ADNEX) model with that of the Risk of Ovarian Malignancy Algorithm (ROMA).This is a retrospective study based on prospectively included consecutive women with an adnexal tumour scheduled for surgery at five oncology centres and one non-oncology centre in four countries between 2015 and 2019. The reference standard was histology. Model performance for ADNEX and ROMA was evaluated regarding discrimination, calibration, and clinical utility.The primary analysis included 894 patients, of whom 434 (49%) had a malignant tumour. The area under the receiver operating characteristic curve (AUC) was 0.92 (95% CI 0.88-0.95) for ADNEX with CA125, 0.90 (0.84-0.94) for ADNEX without CA125, and 0.85 (0.80-0.89) for ROMA. ROMA, and to a lesser extent ADNEX, underestimated the risk of malignancy. Clinical utility was highest for ADNEX. ROMA had no clinical utility at decision thresholds <27%.ADNEX had better ability to discriminate between benign and malignant adnexal tumours and higher clinical utility than ROMA.clinicaltrials.gov NCT01698632 and NCT02847832.
rights: © 2024. The Author(s), under exclusive licence to Springer Nature Limited.
has PII: 10.1038/s41416-024-02578-x
doi: 10.1038/s41416-024-02578-x
creator: OrderedList
  length: 22
  slot:
    index: 1
    item: Landolfo C
      type: Person
      first name: Chiara
      last name: Landolfo
      member of: Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.Department of Development and Regeneration, KU Leuven, Leuven, Belgium.Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
  slot:
    index: 2
    item: Ceusters J
      type: Person
      first name: Jolien
      last name: Ceusters
      member of: Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
  slot:
    index: 3
    item: Valentin L
      type: Person
      first name: Lil
      last name: Valentin
      member of: Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
  slot:
    index: 4
    item: Froyman W
      type: Person
      first name: Wouter
      last name: Froyman
      member of: Department of Development and Regeneration, KU Leuven, Leuven, Belgium.Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 5
    item: Van Gorp T
      type: Person
      first name: Toon
      last name: Van Gorp
      member of: Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.Department of Oncology, Gynaecological Oncology, KU Leuven, Leuven Cancer Institute, Leuven, Belgium.
  slot:
    index: 6
    item: Heremans R
      type: Person
      first name: Ruben
      last name: Heremans
      member of: Department of Development and Regeneration, KU Leuven, Leuven, Belgium.Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 7
    item: Baert T
      type: Person
      first name: Thaïs
      last name: Baert
      member of: Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.Department of Oncology, Gynaecological Oncology, KU Leuven, Leuven Cancer Institute, Leuven, Belgium.
  slot:
    index: 8
    item: Wouters R
      type: Person
      first name: Roxanne
      last name: Wouters
      member of: Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.Oncoinvent AS, Oslo, Norway.
  slot:
    index: 9
    item: Vankerckhoven A
      type: Person
      first name: Ann
      last name: Vankerckhoven
      member of: Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
  slot:
    index: 10
    item: Van Rompuy AS
      type: Person
      first name: Anne-Sophie
      last name: Van Rompuy
      member of: Department of Pathology, UZ Leuven, Leuven, Belgium.
  slot:
    index: 11
    item: Billen J
      type: Person
      first name: Jaak
      last name: Billen
      member of: Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium.
  slot:
    index: 12
    item: Moro F
      type: Person
      first name: Francesca
      last name: Moro
      member of: Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
  slot:
    index: 13
    item: Mascilini F
      type: Person
      first name: Floriana
      last name: Mascilini
      member of: Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
  slot:
    index: 14
    item: Neumann A
      type: Person
      first name: Adam
      last name: Neumann
      member of: Department of Obstetrics and Gynaecology, First Faculty of Medicine, Charles University, Prague, Czech Republic.General University Hospital, Prague, Czech Republic.
  slot:
    index: 15
    item: Van Holsbeke C
      type: Person
      first name: Caroline
      last name: Van Holsbeke
      member of: Department of Obstetrics and Gynecology, Ziekenhuis Oost-Limburg, Genk, Belgium.
  slot:
    index: 16
    item: Chiappa V
      type: Person
      first name: Valentina
      last name: Chiappa
      member of: Department of Gynecologic Oncology, National Cancer Institute of Milan, Milan, Italy.
  slot:
    index: 17
    item: Bourne T
      type: Person
      first name: Tom
      last name: Bourne
      member of: Department of Development and Regeneration, KU Leuven, Leuven, Belgium.Queen Charlotte's and Chelsea Hospital, Imperial College, London, UK.
  slot:
    index: 18
    item: Fischerova D
      type: Person
      first name: Daniela
      last name: Fischerova
      member of: Department of Obstetrics and Gynaecology, First Faculty of Medicine, Charles University, Prague, Czech Republic.General University Hospital, Prague, Czech Republic.
  slot:
    index: 19
    item: Testa A
      type: Person
      first name: Antonia
      last name: Testa
      member of: Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
  slot:
    index: 20
    item: Coosemans A
      type: Person
      first name: An
      last name: Coosemans
      member of: Department of Oncology, Laboratory of Tumour Immunology and Immunotherapy, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
  slot:
    index: 21
    item: Timmerman D
      type: Person
      first name: Dirk
      last name: Timmerman
      member of: Department of Development and Regeneration, KU Leuven, Leuven, Belgium.Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.
  slot:
    index: 22
    item: Van Calster B
      type: Person
      first name: Ben
      last name: Van Calster
      member of: Department of Development and Regeneration, KU Leuven, Leuven, Belgium. ben.vancalster@kuleuven.be.Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands. ben.vancalster@kuleuven.be.Leuven Unit for Health Technology Assessment Research (LUHTAR), KU Leuven, Leuven, Belgium. ben.vancalster@kuleuven.be.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 Apr
created: 2024-1-19T23:25
e ISSN: 1532-1827
has issn l: 0007-0920
issue: 6
has NLM journal title abbreviation: Br J Cancer
publication name: British journal of cancer
language: eng
has national library of medicine journal id: 0370635
derived from: NLM
starting page: 934
ending page: 940
has place of publication: England
has primary subject term: D010051Q000175Q000601Q000473
has primary subject term: D000291Q000175Q000601Q000473
has subject term: D006801
has subject term: D005260
has subject term: D012189
has subject term: D014463
has subject term: D000465
has subject term: D012680
has subject term: D018394
source: Br J Cancer. 2024-04;130(6):934-940.
volume: 130

Histone deacetylase OsHDA716 represses rice chilling tolerance by deacetylating OsbZIP46 to reduce its transactivation function and protein stability.
pmid: 38242836
abstract: Low temperature is a major environmental factor limiting plant growth and crop production. Epigenetic regulation of gene expression is important for plant adaptation to environmental changes, whereas the epigenetic mechanism of cold signaling in rice (Oryza sativa) remains largely elusive. Here, we report that the histone deacetylase (HDAC) OsHDA716 represses rice cold tolerance by interacting with and deacetylating the transcription factor OsbZIP46. The loss-of-function mutants of OsHDA716 exhibit enhanced chilling tolerance, compared with the wild-type plants, while OsHDA716 overexpression plants show chilling hypersensitivity. On the contrary, OsbZIP46 confers chilling tolerance in rice through transcriptionally activating OsDREB1A and COLD1 to regulate cold-induced calcium influx and cytoplasmic calcium elevation. Mechanistic investigation showed that OsHDA716-mediated OsbZIP46 deacetylation in the DNA-binding domain reduces the DNA-binding ability and transcriptional activity as well as decreasing OsbZIP46 protein stability. Genetic evidence indicated that OsbZIP46 deacetylation mediated by OsHDA716 reduces rice chilling tolerance. Collectively, these findings reveal that the functional interplay between the chromatin regulator and transcription factor fine-tunes the cold response in plant and uncover a mechanism by which HDACs repress gene transcription through deacetylating nonhistone proteins and regulating their biochemical functions.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577598
doi: 10.1093/plcell/koae010
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Sun Y
      type: Person
      first name: Ying
      last name: Sun
      member of: Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
  slot:
    index: 2
    item: Xie Z
      type: Person
      first name: Zizhao
      last name: Xie
      member of: Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
  slot:
    index: 3
    item: Jin L
      type: Person
      first name: Liang
      last name: Jin
      member of: Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
  slot:
    index: 4
    item: Qin T
      type: Person
      first name: Tian
      last name: Qin
      member of: Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
  slot:
    index: 5
    item: Zhan C
      type: Person
      first name: Chenghang
      last name: Zhan
      member of: Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
  slot:
    index: 6
    item: Huang J
      type: Person
      first name: Junli
      last name: Huang
      member of: Key Laboratory of Biorheological Science and Technology of Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-05-01
dp: 2024 May 01
created: 2024-1-19T22:13
e ISSN: 1532-298X
has issn l: 1040-4651
issue: 5
has NLM journal title abbreviation: Plant Cell
publication name: The Plant cell
language: eng
has national library of medicine journal id: 9208688
derived from: NLM
starting page: 1913
ending page: 1936
has place of publication: England
has primary subject term: D012275Q000235Q000201Q000378Q000502
has primary subject term: D010940Q000235Q000378
has primary subject term: D006655Q000235Q000378
has primary subject term: D018506
has primary subject term: D003080
has primary subject term: D055550
has primary subject term: D015533Q000235
has subject term: D014157Q000378Q000235
has subject term: D030821
has subject term: D000107
source: Plant Cell. 2024-05-01;36(5):1913-1936.
volume: 36

Degradation of FATTY ACID EXPORT PROTEIN1 by RHOMBOID-LIKE PROTEASE11 contributes to cold tolerance in Arabidopsis.
pmid: 38242838
abstract: Plants need to acclimate to different stresses to optimize growth under unfavorable conditions. In Arabidopsis (Arabidopsis thaliana), the abundance of the chloroplast envelope protein FATTY ACID EXPORT PROTEIN1 (FAX1) decreases after the onset of low temperatures. However, how FAX1 degradation occurs and whether altered FAX1 abundance contributes to cold tolerance in plants remains unclear. The rapid cold-induced increase in RHOMBOID-LIKE PROTEASE11 (RBL11) transcript levels, the physical interaction of RBL11 with FAX1, the specific FAX1 degradation after RBL11 expression, and the absence of cold-induced FAX1 degradation in rbl11 loss-of-function mutants suggest that this enzyme is responsible for FAX1 degradation. Proteomic analyses showed that rbl11 mutants have higher levels of FAX1 and other proteins involved in membrane lipid homeostasis, suggesting that RBL11 is a key element in the remodeling of membrane properties during cold conditions. Consequently, in the cold, rbl11 mutants show a shift in lipid biosynthesis toward the eukaryotic pathway, which coincides with impaired cold tolerance. To test whether cold sensitivity is due to increased FAX1 levels, we analyzed FAX1 overexpressors. The rbl11 mutants and FAX1 overexpressor lines show superimposable phenotypic defects upon exposure to cold temperatures. Our re-sults show that the cold-induced degradation of FAX1 by RBL11 is critical for Arabidop-sis to survive cold and freezing periods.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577599
doi: 10.1093/plcell/koae011
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: John A
      type: Person
      first name: Annalisa
      last name: John
      member of: Plant Physiology, University of Kaiserslautern, Kaiserslautern D-67653, Germany.
  slot:
    index: 2
    item: Krämer M
      type: Person
      first name: Moritz
      last name: Krämer
      member of: Plant Biochemistry, Faculty of Biology, Ludwig-Maximilians-Universität Munich, Planegg-Martinsried 82152, Germany.
  slot:
    index: 3
    item: Lehmann M
      type: Person
      first name: Martin
      last name: Lehmann
      member of: Plant Biochemistry, Faculty of Biology, Ludwig-Maximilians-Universität Munich, Planegg-Martinsried 82152, Germany.
  slot:
    index: 4
    item: Kunz HH
      type: Person
      first name: Hans-Henning
      last name: Kunz
      member of: Plant Biochemistry, Faculty of Biology, Ludwig-Maximilians-Universität Munich, Planegg-Martinsried 82152, Germany.
  slot:
    index: 5
    item: Aarabi F
      type: Person
      first name: Fayezeh
      last name: Aarabi
      member of: Max Planck Institut for Molecular Plant Physiology, Central Metabolism, Potsdam D-14476, Germany.
  slot:
    index: 6
    item: Alseekh S
      type: Person
      first name: Saleh
      last name: Alseekh
      member of: Max Planck Institut for Molecular Plant Physiology, Central Metabolism, Potsdam D-14476, Germany.
  slot:
    index: 7
    item: Fernie A
      type: Person
      first name: Alisdair
      last name: Fernie
      member of: Max Planck Institut for Molecular Plant Physiology, Central Metabolism, Potsdam D-14476, Germany.
  slot:
    index: 8
    item: Sommer F
      type: Person
      first name: Frederik
      last name: Sommer
      member of: Molecular Biotechnology and Systems Biology, University of Kaiserslautern, Kaiserslautern D-67653, Germany.
  slot:
    index: 9
    item: Schroda M
      type: Person
      first name: Michael
      last name: Schroda
      member of: Molecular Biotechnology and Systems Biology, University of Kaiserslautern, Kaiserslautern D-67653, Germany.
  slot:
    index: 10
    item: Zimmer D
      type: Person
      first name: David
      last name: Zimmer
      member of: Computational Systems Biology, University of Kaiserslautern, Kaiserslautern D-67653, Germany.
  slot:
    index: 11
    item: Mühlhaus T
      type: Person
      first name: Timo
      last name: Mühlhaus
      member of: Computational Systems Biology, University of Kaiserslautern, Kaiserslautern D-67653, Germany.
  slot:
    index: 12
    item: Peisker H
      type: Person
      first name: Helga
      last name: Peisker
      member of: Institute for Molecular Physiology and Biotechnology of Plants, IMBIO, University of Bonn, Bonn D-53115, Germany.
  slot:
    index: 13
    item: Gutbrod K
      type: Person
      first name: Katharina
      last name: Gutbrod
      member of: Institute for Molecular Physiology and Biotechnology of Plants, IMBIO, University of Bonn, Bonn D-53115, Germany.
  slot:
    index: 14
    item: Dörmann P
      type: Person
      first name: Peter
      last name: Dörmann
      member of: Institute for Molecular Physiology and Biotechnology of Plants, IMBIO, University of Bonn, Bonn D-53115, Germany.
  slot:
    index: 15
    item: Neunzig J
      type: Person
      first name: Jens
      last name: Neunzig
      member of: Plant Biology, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken D-66123, Germany.
  slot:
    index: 16
    item: Philippar K
      type: Person
      first name: Katrin
      last name: Philippar
      member of: Plant Biology, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken D-66123, Germany.
  slot:
    index: 17
    item: Neuhaus HE
      type: Person
      first name: Horst Ekkehard
      last name: Neuhaus
      member of: Plant Physiology, University of Kaiserslautern, Kaiserslautern D-67653, Germany.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-05-01
dp: 2024 May 01
created: 2024-1-19T22:13
e ISSN: 1532-298X
has issn l: 1040-4651
issue: 5
has NLM journal title abbreviation: Plant Cell
publication name: The Plant cell
language: eng
has national library of medicine journal id: 9208688
derived from: NLM
starting page: 1937
ending page: 1962
has place of publication: England
has primary subject term: D017360Q000235Q000378Q000502
has primary subject term: D029681Q000378Q000235
has primary subject term: D003080
has primary subject term: D018506
has subject term: D050612Q000378Q000235
has subject term: D009154
has subject term: D059748
source: Plant Cell. 2024-05-01;36(5):1937-1962.
volume: 36

Plasmodium malariae and Plasmodium ovale-Prevalent and Relevant.
pmid: 38243611
has PII: 7577765
doi: 10.1093/infdis/jiae015
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Graumans W
      type: Person
      first name: Wouter
      last name: Graumans
      member of: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, the Netherlands.
  slot:
    index: 2
    item: Ayo D
      type: Person
      first name: Daniel
      last name: Ayo
      member of: Infectious Diseases Research Collaboration, Kampala, Uganda.
  slot:
    index: 3
    item: van Lieshout N
      type: Person
      first name: Nadeche
      last name: van Lieshout
      member of: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, the Netherlands.
  slot:
    index: 4
    item: Lanke K
      type: Person
      first name: Kjerstin
      last name: Lanke
      member of: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, the Netherlands.
  slot:
    index: 5
    item: Bousema T
      type: Person
      first name: Teun
      last name: Bousema
      member of: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, the Netherlands.Department of Infection Biology, London School of Hygiene and Tropical Medicine, United Kingdom.
  slot:
    index: 6
    item: Arinaitwe E
      type: Person
      first name: Emmanuel
      last name: Arinaitwe
      member of: Infectious Diseases Research Collaboration, Kampala, Uganda.
created: 2024-1-20T10:43
date last updated: 2025-01-20
issued: 2024-04-12
dp: 2024 Apr 12
created: 2024-1-20T02:00
e ISSN: 1537-6613
has issn l: 0022-1899
issue: 4
has NLM journal title abbreviation: J Infect Dis
publication name: The Journal of infectious diseases
language: eng
has national library of medicine journal id: 0413675
derived from: NLM
starting page: 1239
ending page: 1240
has place of publication: United States
has primary subject term: D041122Q000235
has primary subject term: D008288Q000453
has primary subject term: D010961
has subject term: D006801
has subject term: D010965
source: J Infect Dis. 2024-04-12;229(4):1239-1240.
volume: 229

SUPPRESSOR OF MAX2 1-LIKE (SMXL) homologs are MAX2-dependent repressors of Physcomitrium patens growth.
pmid: 38242840
abstract: SUPPRESSOR OF MAX2 (SMAX)1-LIKE (SMXL) proteins are a plant-specific clade of type I HSP100/Clp-ATPases. SMXL genes are present in virtually all land plant genomes. However, they have mainly been studied in angiosperms. In Arabidopsis (Arabidopsis thaliana), 3 functional SMXL subclades have been identified: SMAX1/SMXL2, SMXL345, and SMXL678. Of these, 2 subclades ensure endogenous phytohormone signal transduction. SMAX1/SMXL2 proteins are involved in KAI2 ligand (KL) signaling, while SMXL678 proteins are involved in strigolactone (SL) signaling. Many questions remain regarding the mode of action of these proteins, as well as their ancestral roles. We addressed these questions by investigating the functions of the 4 SMXL genes in the moss Physcomitrium patens. We demonstrate that PpSMXL proteins are involved in the conserved ancestral MAX2-dependent KL signaling pathway and negatively regulate growth. However, PpSMXL proteins expressed in Arabidopsis cannot replace SMAX1 or SMXL2 function in KL signaling, whereas they can functionally replace SMXL4 and SMXL5 and restore root growth. Therefore, the molecular functions of SMXL proteins are conserved, but their interaction networks are not. Moreover, the PpSMXLC/D clade positively regulates SL signal transduction in P. patens. Overall, our data reveal that SMXL proteins in moss mediate crosstalk between the SL and KL signaling pathways.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577597
doi: 10.1093/plcell/koae009
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Guillory A
      type: Person
      first name: Ambre
      last name: Guillory
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.LIPME, Université de Toulouse, INRAE, CNRS, Castanet-Tolosan 31326, France.
  slot:
    index: 2
    item: Lopez-Obando M
      type: Person
      first name: Mauricio
      last name: Lopez-Obando
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.Institut de biologie moléculaire des plantes (IBMP), CNRS, University of Strasbourg, 12 rue du Général Zimmer, 67000 Strasbourg, France.
  slot:
    index: 3
    item: Bouchenine K
      type: Person
      first name: Khalissa
      last name: Bouchenine
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
  slot:
    index: 4
    item: Le Bris P
      type: Person
      first name: Philippe
      last name: Le Bris
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
  slot:
    index: 5
    item: Lécureuil A
      type: Person
      first name: Alain
      last name: Lécureuil
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
  slot:
    index: 6
    item: Pillot JP
      type: Person
      first name: Jean-Paul
      last name: Pillot
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
  slot:
    index: 7
    item: Steinmetz V
      type: Person
      first name: Vincent
      last name: Steinmetz
      member of: CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  slot:
    index: 8
    item: Boyer FD
      type: Person
      first name: François-Didier
      last name: Boyer
      member of: CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  slot:
    index: 9
    item: Rameau C
      type: Person
      first name: Catherine
      last name: Rameau
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
  slot:
    index: 10
    item: de Saint Germain A
      type: Person
      first name: Alexandre
      last name: de Saint Germain
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
  slot:
    index: 11
    item: Bonhomme S
      type: Person
      first name: Sandrine
      last name: Bonhomme
      member of: Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France.
created: 2024-1-20T05:42
date last updated: 2025-01-20
issued: 2024-05-01
dp: 2024 May 01
created: 2024-1-19T22:13
e ISSN: 1532-298X
has issn l: 1040-4651
issue: 5
has NLM journal title abbreviation: Plant Cell
publication name: The Plant cell
language: eng
has national library of medicine journal id: 9208688
derived from: NLM
starting page: 1655
ending page: 1672
has place of publication: England
has primary subject term: D019068Q000235Q000254Q000378
has primary subject term: D018506
has primary subject term: D010940Q000235Q000378
has primary subject term: D029681Q000378Q000235
has subject term: D017360Q000235Q000378Q000254
has subject term: D015398
has subject term: D010802
has subject term: D007783Q000378
source: Plant Cell. 2024-05-01;36(5):1655-1672.
volume: 36

Correlation between tumor size change and outcome in a rare cancer immunotherapy basket trial.
pmid: 38243705
abstract: RECIST criteria for progressive disease, partial response, and complete response, reflecting +20%, -30%, and -100% tumor size changes, respectively, are critical outcome variables in oncology clinical trials. Herein, we evaluated post-immunotherapy tumor size change correlation with outcomes.We used a unique clinical trial data resource, a multicenter basket trial in patients with rare solid tumors treated with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) between 2017 and 2023 (National Cancer Institute/Southwest Oncology Group-sponsored DART trial [NCT02834013]) (open at 1083 sites at its peak). Outcome associations were evaluated by survival analysis techniques including Martingale residuals.In 638 evaluable patients, we found strong linear relationships between percent change in tumor measurement up to a 40%-50% increase and progression-free (PFS) and overall survival (OS) (both Cox regression P < .001; landmark analyses based on day 65). Pearson R correlation between survival estimates and tumor change category were -0.94, -0.89, and -0.89 (PFS) and -0.84, -0.90, and -0.90 (OS) for median, 6-month (PFS), and 1-year (OS) and for 1-year (PFS) and 2-year (OS) estimates.Percent change in tumor measurement per RECISTv1.1 (the sum of longest dimensions of target lesions) has a linear association with PFS and OS up to a 40% to 50% increase in tumor measurement in this cohort of patients with rare cancers who received combination immune checkpoint blockade. Quantitative first scan tumor measurement changes include important information to evaluate the potential efficacy of a therapy beyond the proportion of patients who achieve an objective response.
rights: © The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
has PII: 7577858
doi: 10.1093/jnci/djae009
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Othus M
      type: Person
      first name: Megan
      last name: Othus
      member of: SWOG Cancer Research Network Statistical Center, Seattle, WA, USA.Division of Public Health, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  slot:
    index: 2
    item: Patel SP
      type: Person
      first name: Sandip P
      last name: Patel
      member of: Department of Medical Oncology, University of California at San Diego Moores Cancer Center, La Jolla, CA, USA.
  slot:
    index: 3
    item: Chae YK
      type: Person
      first name: Young K
      last name: Chae
      member of: Department of Medicine, Northwestern University, Chicago, IL, USA.
  slot:
    index: 4
    item: Dietrich E
      type: Person
      first name: Eliana
      last name: Dietrich
      member of: Division of Public Health, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  slot:
    index: 5
    item: Streicher H
      type: Person
      first name: Howard
      last name: Streicher
      member of: Cancer Therapy Evaluation Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA (during conduct of trial for E Sharon).
  slot:
    index: 6
    item: Sharon E
      type: Person
      first name: Elad
      last name: Sharon
      member of: Cancer Therapy Evaluation Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA (during conduct of trial for E Sharon).Department of Medicine, Dana-Farber/Harvard Cancer Center, Boston, MA, USA (current).
  slot:
    index: 7
    item: Kurzrock R
      type: Person
      first name: Razelle
      last name: Kurzrock
      member of: Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA.
created: 2024-1-20T10:43
date last updated: 2025-01-20
issued: 2024-05-08
dp: 2024 May 08
created: 2024-1-20T03:53
e ISSN: 1460-2105
has issn l: 0027-8874
issue: 5
has NLM journal title abbreviation: J Natl Cancer Inst
publication name: Journal of the National Cancer Institute
language: eng
has national library of medicine journal id: 7503089
derived from: NLM
starting page: 673
ending page: 680
has place of publication: United States
has primary subject term: D007167Q000379
has primary subject term: D009369Q000473Q000188Q000401Q000628Q000276
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D008875
has subject term: D000368
has subject term: D000074324Q000627Q000008
has subject term: D000328
has subject term: D000077594Q000627
has subject term: D066066
has subject term: D000082082Q000627
has subject term: D047368
has subject term: http://id.nlm.nih.gov/mesh/D000077982
has subject term: D016896
has subject term: D000971Q000627
source: J Natl Cancer Inst. 2024-05-08;116(5):673-680.
volume: 116

Multimodal study of multilevel pulvino-temporal connections: a new piece in the puzzle of lexical retrieval networks.
pmid: 38243610
abstract: Advanced methods of imaging and mapping the healthy and lesioned brain have allowed for the identification of the cortical nodes and white matter tracts supporting the dual neurofunctional organization of language networks in a dorsal phonological and a ventral semantic stream. Much less understood are the anatomical correlates of the interaction between the two streams; one hypothesis being that of a subcortically mediated interaction, through crossed cortico-striato-thalamo-cortical and cortico-thalamo-cortical loops. In this regard, the pulvinar is the thalamic subdivision that has most regularly appeared as implicated in the processing of lexical retrieval. However, descriptions of its connections with temporal (language) areas remain scarce. Here we assess this pulvino-temporal connectivity using a combination of state-of-the-art techniques: white matter stimulation in awake surgery and postoperative diffusion MRI (n = 4), virtual dissection from the Human Connectome Project 3 and 7 T datasets (n = 172) and operative microscope-assisted post-mortem fibre dissection (n = 12). We demonstrate the presence of four fundamental fibre contingents: (i) the anterior component (Arnold's bundle proper) initially described by Arnold in the 19th century and destined to the anterior temporal lobe; (ii) the optic radiations-like component, which leaves the pulvinar accompanying the optical radiations and reaches the posterior basal temporal cortices; (iii) the lateral component, which crosses the temporal stem orthogonally and reaches the middle temporal gyrus; and (iv) the auditory radiations-like component, which leaves the pulvinar accompanying the auditory radiations to the superomedial aspect of the temporal operculum, just posteriorly to Heschl's gyrus. Each of those components might correspond to a different level of information processing involved in the lexical retrieval process of picture naming.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7577763
doi: 10.1093/brain/awae021
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Maldonado IL
      type: Person
      first name: Igor Lima
      last name: Maldonado
      member of: UMR 1253, iBrain, Université de Tours, Inserm, 37000 Tours, France.Department of Neurosurgery, CHRU de Tours, 37000 Tours, France.
  slot:
    index: 2
    item: Descoteaux M
      type: Person
      first name: Maxime
      last name: Descoteaux
      member of: Sherbrooke Connectivity Imaging Laboratory, Department of Computer Science, Faculty of Sciences, Université de Sherbrooke, J1K 2X9 Sherbrooke, Quebec, Canada.Imeka Solutions, J1H 4A7 Sherbrooke, Quebec, Canada.
  slot:
    index: 3
    item: Rheault F
      type: Person
      first name: François
      last name: Rheault
      member of: Imeka Solutions, J1H 4A7 Sherbrooke, Quebec, Canada.
  slot:
    index: 4
    item: Zemmoura I
      type: Person
      first name: Ilyess
      last name: Zemmoura
      member of: UMR 1253, iBrain, Université de Tours, Inserm, 37000 Tours, France.Department of Neurosurgery, CHRU de Tours, 37000 Tours, France.
  slot:
    index: 5
    item: Benn A
      type: Person
      first name: Austin
      last name: Benn
      member of: CNRS, Integrative Neuroscience and Cognition Center (UMR 8002), Université de Paris Cité, 75006 Paris, France.Wellcome Centre for Integrative Neuroimaging, University of Oxford, OX1 3QD Oxford, UK.
  slot:
    index: 6
    item: Margulies D
      type: Person
      first name: Daniel
      last name: Margulies
      member of: CNRS, Integrative Neuroscience and Cognition Center (UMR 8002), Université de Paris Cité, 75006 Paris, France.
  slot:
    index: 7
    item: Boré A
      type: Person
      first name: Arnaud
      last name: Boré
      member of: Sherbrooke Connectivity Imaging Laboratory, Department of Computer Science, Faculty of Sciences, Université de Sherbrooke, J1K 2X9 Sherbrooke, Quebec, Canada.
  slot:
    index: 8
    item: Duffau H
      type: Person
      first name: Hugues
      last name: Duffau
      member of: Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 34090 Montpellier, France.Team 'Plasticity of Central Nervous System, Stem Cells and Glial Tumors', U1191 Laboratory, Institute of Functional Genomics, National Institute for Health and Medical Research (INSERM), University of Montpellier, 34000, Montpellier, France.
  slot:
    index: 9
    item: Mandonnet E
      type: Person
      first name: Emmanuel
      last name: Mandonnet
      member of: Department of Neurosurgery, Lariboisière Hospital, AP-HP, 75010 Paris, France.Frontlab, CNRS UMR 7225, INSERM U1127, Paris Brain Institute (ICM), 75013 Paris, France.UFR Médecine, Université de Paris Cité, 75006 Paris, France.
created: 2024-1-20T10:42
date last updated: 2025-01-20
issued: 2024-06-03
dp: 2024 Jun 03
created: 2024-1-20T02:00
e ISSN: 1460-2156
has issn l: 0006-8950
issue: 6
has NLM journal title abbreviation: Brain
publication name: Brain : a journal of neurology
language: eng
has national library of medicine journal id: 0372537
derived from: NLM
starting page: 2245
ending page: 2257
has place of publication: England
has primary subject term: D013702Q000502Q000000981
has primary subject term: D020649Q000502Q000000981
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D000328
has subject term: D009434Q000502
has subject term: D063132
has subject term: D066127Q000000981Q000502
has subject term: D007802
has subject term: D008875
has subject term: D009415Q000502Q000000981
has subject term: D055815
source: Brain. 2024-06-03;147(6):2245-2257.
volume: 147

Nuclear translocation matters: Role of FABP7 in driving glioblastoma stemness and invasion: Reply to Mu et al.
pmid: 38244229
has PII: 7582049
doi: 10.1093/neuonc/noad239
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Liu RZ
      type: Person
      first name: Rong-Zong
      last name: Liu
      member of: Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
  slot:
    index: 2
    item: Choi WS
      type: Person
      first name: Won-Shik
      last name: Choi
      member of: Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
  slot:
    index: 3
    item: Godbout R
      type: Person
      first name: Roseline
      last name: Godbout
      member of: Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
created: 2024-1-20T21:42
date last updated: 2025-01-20
issued: 2024-03-04
dp: 2024 03 04
created: 2024-1-20T16:03
e ISSN: 1523-5866
has issn l: 1522-8517
issue: 3
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
starting page: 590
ending page: 591
has place of publication: England
has primary subject term: D005909Q000378
has primary subject term: D001932Q000378
has subject term: D006801
has subject term: D050556
has subject term: D013234Q000378
has subject term: http://id.nlm.nih.gov/mesh/D000071438
has subject term: D025521Q000378
source: Neuro Oncol. 2024-03-04;26(3):590-591.
volume: 26

Surgical smoke and its components, effects, and mitigation: a contemporary review.
pmid: 38243717
abstract: Energy-based surgical instruments produce surgical smoke, which contains harmful byproducts, such as polycyclic aromatic hydrocarbons, volatile organic compounds, particulate matter, and viable microorganisms. The research setting has shifted from the laboratory to the operating room. However, significant heterogeneity in the methods of detection and placement of samplers, diversity in the tissue operated on, and types of surgeries tested has resulted in variability in detected levels and composition of surgical smoke. State regulation limiting surgical smoke exposure through local evacuators is expanding but has yet to reach the national regulatory level. However, most studies have not shown levels above standard established limits but relatively short bursts of high concentrations of these harmful by-products. This review highlights the limitations of the current research and unsupported conclusions while also suggesting further areas of interest that need more focus to improve Occupational Safety and Health Administration guidelines.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577863
doi: 10.1093/toxsci/kfae005
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Benaim EH
      type: Person
      first name: Ezer H
      last name: Benaim
      member of: Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  slot:
    index: 2
    item: Jaspers I
      type: Person
      first name: Ilona
      last name: Jaspers
      member of: Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.Curriculum in Toxicology & Environmental Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
created: 2024-1-20T10:42
date last updated: 2025-01-20
issued: 2024-03-26
dp: 2024 Mar 26
created: 2024-1-20T03:53
e ISSN: 1096-0929
has issn l: 1096-0929
issue: 2
has NLM journal title abbreviation: Toxicol Sci
publication name: Toxicological sciences : an official journal of the Society of Toxicology
language: eng
has national library of medicine journal id: 9805461
derived from: NLM
starting page: 157
ending page: 168
has place of publication: United States
has primary subject term: D011084
has primary subject term: D055549Q000032
has subject term: D012906Q000009
has subject term: D052638
has subject term: D009873
source: Toxicol Sci. 2024-03-26;198(2):157-168.
volume: 198

Opioid therapy trajectories of patients with chronic non-cancer pain over 1 year of follow-up after initiation of short-acting opioid formulations.
pmid: 38243702
abstract: This study compared opioid utilization trajectories of persons initiating tramadol, short-acting hydrocodone, or short-acting oxycodone, and it characterized opioid dose trajectories and type of opioid in persistent opioid therapy subsamples.A retrospective cohort study of adults with chronic non-cancer pain who were initiating opioid therapy was conducted with the IQVIA PharMetrics® Plus for Academics data (2008-2018). Continuous enrollment was required for 6 months before ( baseline ) and 12 months after ( follow-up ) the first opioid prescription ( index date ). Opioid therapy measures were assessed every 7 days over follow-up. Group-based trajectory modeling (GBTM) was used to identify trajectories for any opioid and total morphine milligram equivalent measures, and longitudinal latent class analysis was used for opioid therapy type.A total of 40 276 tramadol, 141 023 hydrocodone, and 45 221 oxycodone initiators were included. GBTM on any opioid therapy identified 3 latent trajectories: early discontinuers (tramadol 39.0%, hydrocodone 54.1%, oxycodone 61.4%), late discontinuers (tramadol 37.9%, hydrocodone 39.4%, oxycodone 33.3%), and persistent therapy (tramadol 6.7%, hydrocodone 6.5%, oxycodone 5.3%). An additional fourth trajectory, intermittent therapy (tramadol 16.4%), was identified for tramadol initiators. Of those on persistent therapy, 2687 individuals were on persistent therapy with tramadol, 9169 with hydrocodone, and 2377 with oxycodone. GBTM on opioid dose resulted in 6 similar trajectory groups in each persistent therapy group. Longitudinal latent class analysis on opioid therapy type identified 6 latent classes for tramadol and oxycodone and 7 classes for hydrocodone.Opioid therapy patterns meaningfully differed by the initial opioid prescribed, notably the presence of intermittent therapy among tramadol initiators and higher morphine milligram equivalents and prescribing of long-acting opioids among oxycodone initiators.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577847
doi: 10.1093/pm/pnad169
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Acharya M
      type: Person
      first name: Mahip
      last name: Acharya
      member of: Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
  slot:
    index: 2
    item: Hayes CJ
      type: Person
      first name: Corey J
      last name: Hayes
      member of: Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare Systems, North Little Rock, AR 72211, United States.
  slot:
    index: 3
    item: Li C
      type: Person
      first name: Chenghui
      last name: Li
      member of: Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
  slot:
    index: 4
    item: Painter JT
      type: Person
      first name: Jacob T
      last name: Painter
      member of: Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare Systems, North Little Rock, AR 72211, United States.
  slot:
    index: 5
    item: Dayer L
      type: Person
      first name: Lindsey
      last name: Dayer
      member of: College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
  slot:
    index: 6
    item: Martin BC
      type: Person
      first name: Bradley C
      last name: Martin
      member of: Division of Pharmaceutical Evaluation and Policy, Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
created: 2024-1-20T10:43
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 Mar 01
created: 2024-1-20T03:53
e ISSN: 1526-4637
has issn l: 1526-2375
issue: 3
has NLM journal title abbreviation: Pain Med
publication name: Pain medicine (Malden, Mass.)
language: eng
has national library of medicine journal id: 100894201
derived from: NLM
starting page: 173
ending page: 186
has place of publication: England
has primary subject term: D014147Q000627
has primary subject term: D059350Q000188
has subject term: D000328
has subject term: D006801
has subject term: D000701Q000627
has subject term: D010098Q000627
has subject term: D006853Q000627
has subject term: D005500
has subject term: D012189
source: Pain Med. 2024-03-01;25(3):173-186.
volume: 25

Rapidly developing communications materials during public health emergencies: the Âu Cơ campaign in the USA.
pmid: 38243779
abstract: During public health emergencies, health communication materials to contain the outbreak are needed promptly, which prevents the use of standard approaches for getting feedback from the intended audience. We propose a strategy for rapidly obtaining community feedback on new health communication materials during the public health emergencies. We illustrate this with COVID-19 testing campaign in a Vietnamese-American enclave in the USA. The project included community-based COVID-19 testing and communication activities to increase the awareness of the testing centers and encourage frequent testing. Our strategy involves two main components: (i) use of a research team with an existing trust relationship with the community and that includes researchers from that community and (ii) co-design of communication materials using community-based gatekeepers and a cultural broker. We developed brochures and posters to increase the awareness of the COVID-19 testing services. The cultural broker and community-based partners identified salient message concepts and worked with the researchers to define the objectives and content of the materials, which were then reviewed by the entire team. In lieu of standard pretesting, we relied on feedback on mockups of the materials and subsequent revisions from the community-based gatekeepers and cultural broker. Our strategy strikes a balance between the need to urgently disseminate new materials and the need for community input. One key takeaway is that effective planning for public health emergencies must start long before the crisis occurs.
rights: © The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
has PII: 7578626
doi: 10.1093/heapro/daad198
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Meekers D
      type: Person
      first name: Dominique
      last name: Meekers
      member of: Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  slot:
    index: 2
    item: Pham NK
      type: Person
      first name: NhuNgoc K
      last name: Pham
      member of: Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  slot:
    index: 3
    item: Tran CT
      type: Person
      first name: Cam-Thanh
      last name: Tran
      member of: Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  slot:
    index: 4
    item: VanLandingham MJ
      type: Person
      first name: Mark J
      last name: VanLandingham
      member of: Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  slot:
    index: 5
    item: Do M
      type: Person
      first name: Mai
      last name: Do
      member of: Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
created: 2024-1-20T10:42
date last updated: 2025-01-20
issued: 2024-02-01
dp: 2024 Feb 01
created: 2024-1-20T05:53
e ISSN: 1460-2245
has issn l: 0957-4824
issue: 1
has NLM journal title abbreviation: Health Promot Int
publication name: Health promotion international
language: eng
has national library of medicine journal id: 9008939
derived from: NLM
has place of publication: England
has primary subject term: D011634
has primary subject term: D004630
has subject term: D006801
has subject term: http://id.nlm.nih.gov/mesh/D000086742
has subject term: D003142
has subject term: D004196
source: Health Promot Int. 2024-02-01;39(1):.
volume: 39

A paradigm shift in how we treat pediatric low-grade glioma-Targeting the molecular drivers.
pmid: 38243845
has PII: 7578443
doi: 10.1093/neuonc/noae008
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Ziegler DS
      type: Person
      first name: David S
      last name: Ziegler
      member of: Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
  slot:
    index: 2
    item: Lehmann R
      type: Person
      first name: Rebecca
      last name: Lehmann
      member of: Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, New South Wales, Australia.
  slot:
    index: 3
    item: Eisenstat DD
      type: Person
      first name: David D
      last name: Eisenstat
      member of: Children's Cancer Centre, Royal Children's Hospital, Parkville, Victoria, Australia.Murdoch Children's Research Institute, Parkville, Victoria, Australia.Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
created: 2024-1-20T21:41
date last updated: 2025-01-20
issued: 2024-04-05
dp: 2024 04 05
created: 2024-1-20T09:07
e ISSN: 1523-5866
has issn l: 1522-8517
issue: 4
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
starting page: 593
ending page: 595
has place of publication: England
has primary subject term: D005910Q000235Q000628
has primary subject term: D001932Q000235Q000628
has subject term: D002648
has subject term: D006801
source: Neuro Oncol. 2024-04-05;26(4):593-595.
volume: 26

Measuring quality-of-care in treatment of young children with attention-deficit/hyperactivity disorder using pre-trained language models.
pmid: 38244997
abstract: To measure pediatrician adherence to evidence-based guidelines in the treatment of young children with attention-deficit/hyperactivity disorder (ADHD) in a diverse healthcare system using natural language processing (NLP) techniques.We extracted structured and free-text data from electronic health records (EHRs) of all office visits (2015-2019) of children aged 4-6 years in a community-based primary healthcare network in California, who had ≥1 visits with an ICD-10 diagnosis of ADHD. Two pediatricians annotated clinical notes of the first ADHD visit for 423 patients. Inter-annotator agreement (IAA) was assessed for the recommendation for the first-line behavioral treatment (F-measure = 0.89). Four pre-trained language models, including BioClinical Bidirectional Encoder Representations from Transformers (BioClinicalBERT), were used to identify behavioral treatment recommendations using a 70/30 train/test split. For temporal validation, we deployed BioClinicalBERT on 1,020 unannotated notes from other ADHD visits and well-care visits; all positively classified notes (n = 53) and 5% of negatively classified notes (n = 50) were manually reviewed.Of 423 patients, 313 (74%) were male; 298 (70%) were privately insured; 138 (33%) were White; 61 (14%) were Hispanic. The BioClinicalBERT model trained on the first ADHD visits achieved F1 = 0.76, precision = 0.81, recall = 0.72, and AUC = 0.81 [0.72-0.89]. Temporal validation achieved F1 = 0.77, precision = 0.68, and recall = 0.88. Fairness analysis revealed low model performance in publicly insured patients (F1 = 0.53).Deploying pre-trained language models on a variable set of clinical notes accurately captured pediatrician adherence to guidelines in the treatment of children with ADHD. Validating this approach in other patient populations is needed to achieve equitable measurement of quality of care at scale and improve clinical care for mental health conditions.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.
has PII: 7582076
doi: 10.1093/jamia/ocae001
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Pillai M
      type: Person
      first name: Malvika
      last name: Pillai
      member of: Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, United States.
  slot:
    index: 2
    item: Posada J
      type: Person
      first name: Jose
      last name: Posada
      member of: Computer Science Department, University of the North, Barranquilla 080020, Colombia.
  slot:
    index: 3
    item: Gardner RM
      type: Person
      first name: Rebecca M
      last name: Gardner
      member of: Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94305, United States.
  slot:
    index: 4
    item: Hernandez-Boussard T
      type: Person
      first name: Tina
      last name: Hernandez-Boussard
      member of: Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA 94305, United States.
  slot:
    index: 5
    item: Bannett Y
      type: Person
      first name: Yair
      last name: Bannett
      member of: Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, United States.
created: 2024-1-21T00:42
date last updated: 2025-01-20
issued: 2024-04-03
dp: 2024 04 03
created: 2024-1-20T20:13
e ISSN: 1527-974X
has issn l: 1067-5027
issue: 4
has NLM journal title abbreviation: J Am Med Inform Assoc
publication name: Journal of the American Medical Informatics Association : JAMIA
language: eng
has national library of medicine journal id: 9430800
derived from: NLM
starting page: 949
ending page: 957
has place of publication: England
has primary subject term: D001289Q000175Q000188
has subject term: D002648
has subject term: D006801
has subject term: D008297
has subject term: D002675
has subject term: D005260
has subject term: D006630
has subject term: D019983
has subject term: http://id.nlm.nih.gov/mesh/D000072143
has subject term: D009323
source: J Am Med Inform Assoc. 2024-04-03;31(4):949-957.
volume: 31

Domestication and the evolution of crops: variable syndromes, complex genetic architectures, and ecological entanglements.
pmid: 38243576
abstract: Domestication can be considered a specialized mutualism in which a domesticator exerts control over the reproduction or propagation (fitness) of a domesticated species to gain resources or services. The evolution of crops by human-associated selection provides a powerful set of models to study recent evolutionary adaptations and their genetic bases. Moreover, the domestication and dispersal of crops such as rice, maize, and wheat during the Holocene transformed human social and political organization by serving as the key mechanism by which human societies fed themselves. Here we review major themes and identify emerging questions in three fundamental areas of crop domestication research: domestication phenotypes and syndromes, genetic architecture underlying crop evolution, and the ecology of domestication. Current insights on the domestication syndrome in crops largely come from research on cereal crops such as rice and maize, and recent work indicates distinct domestication phenotypes can arise from different domestication histories. While early studies on the genetics of domestication often identified single large-effect loci underlying major domestication traits, emerging evidence supports polygenic bases for many canonical traits such as shattering and plant architecture. Adaptation in human-constructed environments also influenced ecological traits in domesticates such as resource acquisition rates and interactions with other organisms such as root mycorrhizal fungi and pollinators. Understanding the ecological context of domestication will be key to developing resource-efficient crops and implementing more sustainable land management and cultivation practices.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577726
doi: 10.1093/plcell/koae013
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Alam O
      type: Person
      first name: Ornob
      last name: Alam
      member of: Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA.
  slot:
    index: 2
    item: Purugganan MD
      type: Person
      first name: Michael D
      last name: Purugganan
      member of: Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA.Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.Institute for the Study of the Ancient World, New York University, New York, NY, 10028, USA.
created: 2024-1-20T10:42
date last updated: 2025-01-20
issued: 2024-05-01
dp: 2024 May 01
created: 2024-1-20T01:13
e ISSN: 1532-298X
has issn l: 1040-4651
issue: 5
has NLM journal title abbreviation: Plant Cell
publication name: The Plant cell
language: eng
has national library of medicine journal id: 9208688
derived from: NLM
starting page: 1227
ending page: 1241
has place of publication: England
has primary subject term: http://id.nlm.nih.gov/mesh/D000071278
has primary subject term: D018556Q000235
has subject term: D005075
has subject term: D010641
has subject term: D006801
source: Plant Cell. 2024-05-01;36(5):1227-1241.
volume: 36

Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.
pmid: 38243818
abstract: Isocitrate dehydrogenase (IDH) mutant astrocytoma grading, until recently, has been entirely based on morphology. The 5th edition of the Central Nervous System World Health Organization (WHO) introduces CDKN2A/B homozygous deletion as a biomarker of grade 4. We sought to investigate the prognostic impact of DNA methylation-derived molecular biomarkers for IDH mutant astrocytoma.We analyzed 98 IDH mutant astrocytomas diagnosed at NYU Langone Health between 2014 and 2022. We reviewed DNA methylation subclass, CDKN2A/B homozygous deletion, and ploidy and correlated molecular biomarkers with histological grade, progression free (PFS), and overall (OS) survival. Findings were confirmed using 2 independent validation cohorts.There was no significant difference in OS or PFS when stratified by histologic WHO grade alone, copy number complexity, or extent of resection. OS was significantly different when patients were stratified either by CDKN2A/B homozygous deletion or by DNA methylation subclass (P value = .0286 and .0016, respectively). None of the molecular biomarkers were associated with significantly better PFS, although DNA methylation classification showed a trend (P value = .0534).The current WHO recognized grading criteria for IDH mutant astrocytomas show limited prognostic value. Stratification based on DNA methylation shows superior prognostic value for OS.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: 7578744
doi: 10.1093/neuonc/noae009
creator: OrderedList
  length: 26
  slot:
    index: 1
    item: Galbraith K
      type: Person
      first name: Kristyn
      last name: Galbraith
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 2
    item: Garcia M
      type: Person
      first name: Mekka
      last name: Garcia
      member of: Department of Neurology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 3
    item: Wei S
      type: Person
      first name: Siyu
      last name: Wei
      member of: Department of Biostatistics, NYU School of Global Public Health, New York, New York, USA.
  slot:
    index: 4
    item: Chen A
      type: Person
      first name: Anna
      last name: Chen
      member of: Department of Radiology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 5
    item: Schroff C
      type: Person
      first name: Chanel
      last name: Schroff
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 6
    item: Serrano J
      type: Person
      first name: Jonathan
      last name: Serrano
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 7
    item: Pacione D
      type: Person
      first name: Donato
      last name: Pacione
      member of: Department of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 8
    item: Placantonakis DG
      type: Person
      first name: Dimitris G
      last name: Placantonakis
      member of: Department of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 9
    item: William CM
      type: Person
      first name: Christopher M
      last name: William
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 10
    item: Faustin A
      type: Person
      first name: Arline
      last name: Faustin
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 11
    item: Zagzag D
      type: Person
      first name: David
      last name: Zagzag
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 12
    item: Barbaro M
      type: Person
      first name: Marissa
      last name: Barbaro
      member of: Department of Neuro-oncology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 13
    item: Eibl MDPGP
      type: Person
      first name: Maria Del Pilar Guillermo Prieto
      last name: Eibl
      member of: Department of Neuro-oncology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 14
    item: Shirahata M
      type: Person
      first name: Mitsuaki
      last name: Shirahata
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 15
    item: Reuss D
      type: Person
      first name: David
      last name: Reuss
      member of: Department of Neuropathology, Ruprecht-Karls-University, Heidelberg, Germany.CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  slot:
    index: 16
    item: Tran QT
      type: Person
      first name: Quynh T
      last name: Tran
      member of: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  slot:
    index: 17
    item: Alom Z
      type: Person
      first name: Zahangir
      last name: Alom
      member of: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  slot:
    index: 18
    item: von Deimling A
      type: Person
      first name: Andreas
      last name: von Deimling
      member of: Department of Neuropathology, Ruprecht-Karls-University, Heidelberg, Germany.CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  slot:
    index: 19
    item: Orr BA
      type: Person
      first name: Brent A
      last name: Orr
      member of: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  slot:
    index: 20
    item: Sulman EP
      type: Person
      first name: Erik P
      last name: Sulman
      member of: Department of Radiation Oncology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, New York, New York, USA.
  slot:
    index: 21
    item: Golfinos JG
      type: Person
      first name: John G
      last name: Golfinos
      member of: Department of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 22
    item: Orringer DA
      type: Person
      first name: Daniel A
      last name: Orringer
      member of: Department of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 23
    item: Jain R
      type: Person
      first name: Rajan
      last name: Jain
      member of: Department of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 24
    item: Lieberman E
      type: Person
      first name: Evan
      last name: Lieberman
      member of: Department of Radiology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
  slot:
    index: 25
    item: Feng Y
      type: Person
      first name: Yang
      last name: Feng
      member of: Department of Biostatistics, NYU School of Global Public Health, New York, New York, USA.
  slot:
    index: 26
    item: Snuderl M
      type: Person
      first name: Matija
      last name: Snuderl
      member of: Department of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, New York, New York, USA.
created: 2024-1-20T21:41
date last updated: 2025-01-20
issued: 2024-06-03
dp: 2024 06 03
created: 2024-1-20T09:05
e ISSN: 1523-5866
has issn l: 1522-8517
issue: 6
has NLM journal title abbreviation: Neuro Oncol
publication name: Neuro-oncology
language: eng
has national library of medicine journal id: 100887420
derived from: NLM
starting page: 1042
ending page: 1051
has place of publication: England
has primary subject term: D001254Q000235Q000473Q000401
has primary subject term: D019175
has primary subject term: D007521Q000235
has primary subject term: D019941Q000235
has primary subject term: D009154
has primary subject term: D014408Q000235
has primary subject term: D001932Q000235Q000473Q000401
has subject term: D006801
has subject term: D008297
has subject term: D011379
has subject term: D005260
has subject term: D008875
has subject term: D000328
has subject term: D050762Q000235
has subject term: D000368
has subject term: D015996
has subject term: D005500
has subject term: D055815
has subject term: D006720
has subject term: D017353
source: Neuro Oncol. 2024-06-03;26(6):1042-1051.
volume: 26

Breast Imaging Fellowship Virtual Interviews: The Program Director's Perspective.
pmid: 38243860
abstract: To evaluate breast imaging fellowship program directors' perspectives on the virtual interview process.A 20-question survey constructed by members of the Fellowship Match Committee of the Society of Breast Imaging was distributed to all 99 breast imaging program directors registered with the Society. An initial e-mail with a link to the survey was distributed on September 9, 2022, and the survey was closed on October 1, 2022. Results were compiled and a descriptive statistical analysis was performed utilizing Microsoft Excel.There were 63 total responses (63/99, 64% response rate). There was a wide distribution in both the number of applications received and the number of interviews each program offered. Just under a fifth (12/63, 19%) of programs received 1 to 5 applications, whereas a quarter (16/63, 25%) received over 40 applications. In contrast, over a quarter (17/63, 27%) of programs interviewed 1 to 5 applicants, and only a small number (3/63, 5%) interviewed over 40 applicants. When reporting what worked best with the virtual interview process, the responses fell into the following 4 categories: efficiency, flexibility, virtual format, or other. When reporting what did not work well, the most common response (14/37, 38%) was conveying the atmosphere of the program in the virtual setting.This study provides an assessment of the virtual interview experience from the perspective of breast imaging fellowship programs, which may be useful in optimizing future interview experiences for programs and applicants.
rights: © Society of Breast Imaging 2023. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7425383
doi: 10.1093/jbi/wbad072
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Katzen J
      type: Person
      first name: Janine
      last name: Katzen
      member of: Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
  slot:
    index: 2
    item: Nguyen J
      type: Person
      first name: Jonathan
      last name: Nguyen
      member of: Department of Radiology, University of Virginia, Charlottesville, VA, USA.
  slot:
    index: 3
    item: Zuckerman S
      type: Person
      first name: Samantha
      last name: Zuckerman
      member of: Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
  slot:
    index: 4
    item: Wang L
      type: Person
      first name: Lilian
      last name: Wang
      member of: Department of Radiology, Northwestern Medicine, Chicago, IL, USA.
  slot:
    index: 5
    item: Whitman G
      type: Person
      first name: Gary
      last name: Whitman
      member of: Anderson Cancer Center, The University of Texas, Houston, MD, USA.
  slot:
    index: 6
    item: Mango V
      type: Person
      first name: Victoria
      last name: Mango
      member of: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
created: 2024-1-20T21:42
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 Jan 19
created: 2024-1-20T09:08
e ISSN: 2631-6129
has issn l: 2631-6110
issue: 1
has NLM journal title abbreviation: J Breast Imaging
publication name: Journal of breast imaging
language: eng
has national library of medicine journal id: 101752190
derived from: NLM
starting page: 80
ending page: 85
has place of publication: United States
has primary subject term: D005257
has primary subject term: D010560Q000379
has subject term: D012107
has subject term: D011795
source: J Breast Imaging. 2024-01-19;6(1):80-85.
volume: 6

Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk.
pmid: 38243829
abstract: RNA-based, antibody-based, and genome editing-based therapies are currently under investigation to determine if the inhibition of angiopoietin-like protein-3 (ANGPTL3) could reduce lipoprotein-lipid levels and atherosclerotic cardiovascular disease (ASCVD) risk. Mendelian randomisation (MR) was used to determine whether genetic variations influencing ANGPTL3 liver gene expression, blood levels, and protein structure could causally influence triglyceride and apolipoprotein B (apoB) levels as well as coronary artery disease (CAD), ischaemic stroke (IS), and other cardiometabolic diseases.RNA sequencing of 246 explanted liver samples and genome-wide genotyping was performed to identify single-nucleotide polymorphisms (SNPs) associated with liver expression of ANGPTL3. Genome-wide summary statistics of plasma protein levels of ANGPTL3 from the deCODE study (n = 35 359) were used. A total of 647 carriers of ANGPTL3 protein-truncating variants (PTVs) associated with lower plasma triglyceride levels were identified in the UK Biobank. Two-sample MR using SNPs that influence ANGPTL3 liver expression or ANGPTL3 plasma protein levels as exposure and cardiometabolic diseases as outcomes was performed (CAD, IS, heart failure, non-alcoholic fatty liver disease, acute pancreatitis, and type 2 diabetes). The impact of rare PTVs influencing plasma triglyceride levels on apoB levels and CAD was also investigated in the UK Biobank.In two-sample MR studies, common genetic variants influencing ANGPTL3 hepatic or blood expression levels of ANGPTL3 had a very strong effect on plasma triglyceride levels, a more modest effect on low-density lipoprotein cholesterol, a weaker effect on apoB levels, and no effect on CAD or other cardiometabolic diseases. In the UK Biobank, the carriers of rare ANGPTL3 PTVs providing lifelong reductions in median plasma triglyceride levels [-0.37 (interquartile range 0.41) mmol/L] had slightly lower apoB levels (-0.06 ± 0.32 g/L) and similar CAD event rates com[cell cut: 2483 characters, first 2000 kept]
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7578379
doi: 10.1093/eurheartj/ehad845
creator: OrderedList
  length: 17
  slot:
    index: 1
    item: Gobeil É
      type: Person
      first name: Émilie
      last name: Gobeil
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 2
    item: Bourgault J
      type: Person
      first name: Jérôme
      last name: Bourgault
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 3
    item: Mitchell PL
      type: Person
      first name: Patricia L
      last name: Mitchell
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 4
    item: Houessou U
      type: Person
      first name: Ursula
      last name: Houessou
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 5
    item: Gagnon E
      type: Person
      first name: Eloi
      last name: Gagnon
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 6
    item: Girard A
      type: Person
      first name: Arnaud
      last name: Girard
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 7
    item: Paulin A
      type: Person
      first name: Audrey
      last name: Paulin
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 8
    item: Manikpurage HD
      type: Person
      first name: Hasanga D
      last name: Manikpurage
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 9
    item: Côté V
      type: Person
      first name: Valérie
      last name: Côté
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 10
    item: Couture C
      type: Person
      first name: Christian
      last name: Couture
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.
  slot:
    index: 11
    item: Marceau S
      type: Person
      first name: Simon
      last name: Marceau
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada.
  slot:
    index: 12
    item: Bossé Y
      type: Person
      first name: Yohan
      last name: Bossé
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, Canada.
  slot:
    index: 13
    item: Thériault S
      type: Person
      first name: Sébastien
      last name: Thériault
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, Canada.
  slot:
    index: 14
    item: Mathieu P
      type: Person
      first name: Patrick
      last name: Mathieu
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada.
  slot:
    index: 15
    item: Vohl MC
      type: Person
      first name: Marie-Claude
      last name: Vohl
      member of: School of Nutrition, Université Laval, Québec, Canada.Centre Nutrition, santé et société, Institut sur la nutrition et les aliments fonctionnels, Université Laval, Québec, Canada.
  slot:
    index: 16
    item: Tchernof A
      type: Person
      first name: André
      last name: Tchernof
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.School of Nutrition, Université Laval, Québec, Canada.
  slot:
    index: 17
    item: Arsenault BJ
      type: Person
      first name: Benoit J
      last name: Arsenault
      member of: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 chemin Ste-Foy, Québec, QC G1V 4G5, Canada.Department of Medicine, Faculty of Medicine, Université Laval, 2325 Rue de l'Université, Québec, QC G1V 0A6, Canada.
created: 2024-1-20T21:41
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 Mar 01
created: 2024-1-20T09:06
e ISSN: 1522-9645
has issn l: 0195-668X
issue: 9
has NLM journal title abbreviation: Eur Heart J
publication name: European heart journal
language: eng
has national library of medicine journal id: 8006263
derived from: NLM
starting page: 707
ending page: 721
has place of publication: England
has primary subject term: D002545
has primary subject term: D003924
has primary subject term: D010195
has primary subject term: D020521
has primary subject term: D050197
has primary subject term: D003324Q000235
has subject term: D006801
has subject term: D000208
has subject term: http://id.nlm.nih.gov/mesh/D000091303
has subject term: D000906
has subject term: D001055Q000235
has subject term: D014280
source: Eur Heart J. 2024-03-01;45(9):707-721.
volume: 45

The chromatographic fingerprinting study and genotoxicity evaluation of aqueous extract from Cyclocarya paliurus leaves.
pmid: 38250584
abstract: Cyclocarya paliurus leaf is a medicinal and edible homologous plant, which possess various bioactive components with significant health benefits. However, the quality and safety of the aqueous extract from Cyclocarya paliurus leaves (CPLAE) vary greatly due to the raw materials and preparation technology. At present, chromatographic fingerprinting has been widely used for qualitative and quantitative analysis of traditional Chinese medicine (TCM). In this study, a method combining high performance liquid chromatography (HPLC) fingerprint with quantitative analysis was established and successfully applied to the characterization and quality evaluation of the CPLAE. In addition, the genetic safety of the CPLAE was evaluated by genotoxicity tests, including Ames test, chromosomal aberration test of Chinese hamster lung (CHL) cell in vitro, and bone marrow micronucleus test in mice. The results showed that 10 batches of CPLAE samples were analyzed by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS), and the similarity of chromatographic fingerprint of each batch was above 0.961, indicating good similarity. At the same time, the 6 compounds with high absorption strength in the chromatogram were quantitatively analyzed. The results showed that all 6 compounds had good regression (R2=1.000) in the test range, and the recoveries ranged from 96.25% to 102.46%. The results of the 3 genotoxicity tests showed that the highest dose of CPLAE had no genotoxicity. In conclusion, the newly established chromatographic fingerprint and multi-component quantitative analysis method is stable and accurate, and can be used for the identification and quality evaluation of the CPLAE. Moreover, the CPLAE has the characteristics of safety and high quality as functional materials in food.
rights: © The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
has PII: tfae007
doi: 10.1093/toxres/tfae007
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Zhao H
      type: Person
      first name: Hongwei
      last name: Zhao
      member of: Scientific Research Center, Infinitus (China) Company Ltd., 6th Floor, Tower A, Infinitus Plaza, 2nd Yuncheng South Road, Baiyun District, Guangzhou 510000, P.R. China.
  slot:
    index: 2
    item: Yang X
      type: Person
      first name: Xiaobing
      last name: Yang
      member of: Scientific Research Center, Infinitus (China) Company Ltd., 6th Floor, Tower A, Infinitus Plaza, 2nd Yuncheng South Road, Baiyun District, Guangzhou 510000, P.R. China.
  slot:
    index: 3
    item: Wang L
      type: Person
      first name: Lei
      last name: Wang
      member of: Scientific Research Center, Infinitus (China) Company Ltd., 6th Floor, Tower A, Infinitus Plaza, 2nd Yuncheng South Road, Baiyun District, Guangzhou 510000, P.R. China.
  slot:
    index: 4
    item: Huang X
      type: Person
      first name: Xianju
      last name: Huang
      member of: Ethnopharmacology Level 3 Laboratory, National Administration of Traditional Chinese Medicine, South-Central Minzu University, 182 Minyuan Road, Hongshan District, Wuhan 430074, P.R. China.
created: 2024-1-22T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-1-22T05:26
ISSN: 2045-452X
has issn l: 2045-452X
issue: 1
has NLM journal title abbreviation: Toxicol Res (Camb)
publication name: Toxicology research
language: eng
has national library of medicine journal id: 101587950
derived from: NLM
pg: tfae007
has place of publication: England
source: Toxicol Res (Camb). 2024-02;13(1):tfae007.
volume: 13

FGF21 Induces Skeletal Muscle Atrophy and Increases Amino Acids in Female Mice: A Potential Role for Glucocorticoids.
pmid: 38244215
abstract: Fibroblast growth factor-21 (FGF21) is an intercellular signaling molecule secreted by metabolic organs, including skeletal muscle, in response to intracellular stress. FGF21 crosses the blood-brain barrier and acts via the nervous system to coordinate aspects of the adaptive starvation response, including increased lipolysis, gluconeogenesis, fatty acid oxidation, and activation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Given its beneficial effects for hepatic lipid metabolism, pharmaceutical FGF21 analogues are used in clinical trials treatment of fatty liver disease. We predicted pharmacologic treatment with FGF21 increases HPA axis activity and skeletal muscle glucocorticoid signaling and induces skeletal muscle atrophy in mice. Here we found a short course of systemic FGF21 treatment decreased muscle protein synthesis and reduced tibialis anterior weight; this was driven primarily by its effect in female mice. Similarly, intracerebroventricular FGF21 reduced tibialis anterior muscle fiber cross-sectional area; this was more apparent among female mice than male littermates. In agreement with the reduced muscle mass, the topmost enriched metabolic pathways in plasma collected from FGF21-treated females were related to amino acid metabolism, and the relative abundance of plasma proteinogenic amino acids was increased up to 3-fold. FGF21 treatment increased hypothalamic Crh mRNA, plasma corticosterone, and adrenal weight, and increased expression of glucocorticoid receptor target genes known to reduce muscle protein synthesis and/or promote degradation. Given the proposed use of FGF21 analogues for the treatment of metabolic disease, the study is both physiologically relevant and may have important clinical implications.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7581884
doi: 10.1210/endocr/bqae004
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Larson KR
      type: Person
      first name: Karlton R
      last name: Larson
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 2
    item: Jayakrishnan D
      type: Person
      first name: Devi
      last name: Jayakrishnan
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 3
    item: Soto Sauza KA
      type: Person
      first name: Karla A
      last name: Soto Sauza
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 4
    item: Goodson ML
      type: Person
      first name: Michael L
      last name: Goodson
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 5
    item: Chaffin AT
      type: Person
      first name: Aki T
      last name: Chaffin
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 6
    item: Davidyan A
      type: Person
      first name: Arik
      last name: Davidyan
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.Department of Biological Sciences, California State University Sacramento, Sacramento, CA 95819, USA.
  slot:
    index: 7
    item: Pathak S
      type: Person
      first name: Suraj
      last name: Pathak
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 8
    item: Fang Y
      type: Person
      first name: Yanbin
      last name: Fang
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 9
    item: Gonzalez Magaña D
      type: Person
      first name: Diego
      last name: Gonzalez Magaña
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
  slot:
    index: 10
    item: Miller BF
      type: Person
      first name: Benjamin F
      last name: Miller
      member of: Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
  slot:
    index: 11
    item: Ryan KK
      type: Person
      first name: Karen K
      last name: Ryan
      member of: Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA.
created: 2024-1-20T21:42
date last updated: 2025-01-20
issued: 2024-01-16
dp: 2024 Jan 16
created: 2024-1-20T15:37
e ISSN: 1945-7170
has issn l: 0013-7227
issue: 3
has NLM journal title abbreviation: Endocrinology
publication name: Endocrinology
language: eng
has national library of medicine journal id: 0375040
derived from: NLM
has place of publication: United States
has primary subject term: D005938Q000378
has primary subject term: D000596Q000378
has subject term: D008297
has subject term: D051379
has subject term: D005260
has subject term: D000818
has subject term: D007030Q000378
has subject term: D010913Q000378
has subject term: D008099Q000378
has subject term: D005346Q000378
has subject term: D009133Q000378
has subject term: D018482Q000378
has subject term: D009124Q000378
source: Endocrinology. 2024-01-16;165(3):.
volume: 165

The economics of heart failure care.
pmid: 38244828
abstract: Heart failure (HF) poses a significant economic burden in the US, with costs projected to reach $70 billion by 2030. Cost-effectiveness analyses play a pivotal role in assessing the economic value of HF therapies. In this review, we overview the cost-effectiveness of HF therapies and discuss ways to improve patient access. Based on current costs, guideline directed medical therapies for HF with reduced ejection fraction provide high economic value except for sodium-glucose cotransporter-2 inhibitors, which provide intermediate economic value. Combining therapy with the four pillars of medical therapy also has intermediate economic value, with incremental cost-effectiveness ratios ranging from $73,000 to $98,500/ quality adjusted life-years. High economic value procedures include cardiac resynchronization devices, implantable cardioverter-defibrillators, and coronary artery bypass surgery. In contrast, advanced HF therapies have previously demonstrated intermediate to low economic value, but newer data appear more favorable. Given the affordability challenges of HF therapies, additional efforts are needed to ensure optimal care for patients. The recent Inflation Reduction Act contains provisions to reform policy pertaining to drug price negotiation and out-of-pocket spending, as well as measures to increase access to existing programs, including the Medicare low-income subsidy. On a patient level, it is also important to encourage patient and physician awareness and discussions surrounding medical costs. Overall, a broad approach to improving available therapies and access to care is needed to reduce the growing clinical and economic morbidity of HF.
rights: Copyright © 2024 Elsevier Inc. All rights reserved.
has PII: S0033-0620(24)00010-0
doi: 10.1016/j.pcad.2024.01.010
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Wei C
      type: Person
      first name: Chen
      last name: Wei
      member of: Department of Medicine, Stanford University School of Medicine, United States of America.
  slot:
    index: 2
    item: Heidenreich PA
      type: Person
      first name: Paul A
      last name: Heidenreich
      member of: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, United States of America; Palo Alto Veterans Affairs Healthcare System, Palo Alto, CA, United States of America.
  slot:
    index: 3
    item: Sandhu AT
      type: Person
      first name: Alexander T
      last name: Sandhu
      member of: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, United States of America; Palo Alto Veterans Affairs Healthcare System, Palo Alto, CA, United States of America. Electronic address: ats114@stanford.edu.
created: 2024-1-21T00:42
date last updated: 2025-01-20
created: 2024-1-20T19:18
e ISSN: 1873-1740
has issn l: 0033-0620
has NLM journal title abbreviation: Prog Cardiovasc Dis
publication name: Progress in cardiovascular diseases
language: eng
has national library of medicine journal id: 0376442
derived from: NLM
starting page: 90
ending page: 101
has place of publication: United States
has primary subject term: D000077203Q000627
has primary subject term: D006333Q000628Q000188
has primary subject term: D017147
has subject term: D000368
has subject term: D006801
has subject term: D014481
has subject term: D003362
has subject term: D006278
source: Prog Cardiovasc Dis. ;82():90-101.
volume: 82

Artificial Intelligence Decision Support for Triple-Negative Breast Cancers on Ultrasound.
pmid: 38243859
abstract: To assess performance of an artificial intelligence (AI) decision support software in assessing and recommending biopsy of triple-negative breast cancers (TNBCs) on US.Retrospective institutional review board-approved review identified patients diagnosed with TNBC after US-guided biopsy between 2009 and 2019. Artificial intelligence output for TNBCs on diagnostic US included lesion features (shape, orientation) and likelihood of malignancy category (benign, probably benign, suspicious, and probably malignant). Artificial intelligence true positive was defined as suspicious or probably malignant and AI false negative (FN) as benign or probably benign. Artificial intelligence and radiologist lesion feature agreement, AI and radiologist sensitivity and FN rate (FNR), and features associated with AI FNs were determined using Wilcoxon rank-sum test, Fisher's exact test, chi-square test of independence, and kappa statistics.The study included 332 patients with 345 TNBCs. Artificial intelligence and radiologists demonstrated moderate agreement for lesion shape and orientation (k = 0.48 and k = 0.47, each P <.001). On the set of examinations using 6 earlier diagnostic US, radiologists recommended biopsy of 339/345 lesions (sensitivity 98.3%, FNR 1.7%), and AI recommended biopsy of 333/345 lesions (sensitivity 96.5%, FNR 3.5%), including 6/6 radiologist FNs. On the set of examinations using immediate prebiopsy diagnostic US, AI recommended biopsy of 331/345 lesions (sensitivity 95.9%, FNR 4.1%). Artificial intelligence FNs were more frequently oval (q < 0.001), parallel (q < 0.001), circumscribed (q = 0.04), and complex cystic and solid (q = 0.006).Artificial intelligence accurately recommended biopsies for 96% to 97% of TNBCs on US and may assist radiologists in classifying these lesions, which often demonstrate benign sonographic features.
rights: © Society of Breast Imaging 2023. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7334081
doi: 10.1093/jbi/wbad080
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Coffey K
      type: Person
      first name: Kristen
      last name: Coffey
      member of: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  slot:
    index: 2
    item: Aukland B
      type: Person
      first name: Brianna
      last name: Aukland
      member of: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  slot:
    index: 3
    item: Amir T
      type: Person
      first name: Tali
      last name: Amir
      member of: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  slot:
    index: 4
    item: Sevilimedu V
      type: Person
      first name: Varadan
      last name: Sevilimedu
      member of: Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  slot:
    index: 5
    item: Saphier NB
      type: Person
      first name: Nicole B
      last name: Saphier
      member of: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  slot:
    index: 6
    item: Mango VL
      type: Person
      first name: Victoria L
      last name: Mango
      member of: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
created: 2024-1-20T21:41
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 Jan 19
created: 2024-1-20T09:08
e ISSN: 2631-6129
has issn l: 2631-6110
issue: 1
has NLM journal title abbreviation: J Breast Imaging
publication name: Journal of breast imaging
language: eng
has national library of medicine journal id: 101752190
derived from: NLM
starting page: 33
ending page: 44
has place of publication: United States
has primary subject term: D001185
has primary subject term: D064726Q000175
has subject term: D006801
has subject term: D012189
has subject term: D014463
has subject term: D001706
source: J Breast Imaging. 2024-01-19;6(1):33-44.
volume: 6

Neurological Manifestations of Infectious Diseases: Insights From Recent Cases.
pmid: 38288186
abstract: This narrative review examines the complex connection between infectious diseases and their neurological effects. It provides a detailed analysis of recent instances and insights derived from various pathogens. As we explore the realm of infectious agents, including viruses, bacteria, parasites, and fungi, a thorough and diverse analysis reveals the intricacies of neurological problems. The review begins by examining viral infections, specifically focusing on how viruses invade the neurological system and its subsequent effects. Significant instances from recent widespread disease outbreaks function as instructive benchmarks, highlighting the progressing comprehension of these ever-changing interconnections. The article examines the complex pathophysiology of neurological problems caused by bacterial infections. It presents current cases that illustrate the various ways these complications might manifest and the difficulties faced in their therapeutic management. Parasitic and fungal infections, which are typically overlooked, are being carefully examined to emphasize their distinct role in causing neurological complications. The mentioned cases highlight the importance of being thoroughly aware of these less-explored areas ranging from protozoan parasites to opportunistic fungal infections. In addition to the immediate effects caused by infectious agents, the review investigates autoimmune responses activated by infections. It provides a detailed examination of specific instances that shed light on the complex relationship between viral triggers and future neurological problems. This text elaborates on the intricacy of autoimmune-related neurological issues, highlighting the necessity for a comprehensive approach to diagnosing and treating them. The narrative next redirects its attention to the diagnostic difficulties that arise when interpreting the neurological symptoms of viral disorders. This article provides a thorough examination of existing diagnostic tools,[cell cut: 3164 characters, first 2000 kept]
rights: Copyright © 2023, Kashyap et al.
doi: 10.7759/cureus.51256
creator: OrderedList
  length: 16
  slot:
    index: 1
    item: Kashyap J
      type: Person
      first name: Jyoti
      last name: Kashyap
      member of: Medicine, Sri Balaji Action Medical Institute, Delhi, IND.
  slot:
    index: 2
    item: Olanrewaju OA
      type: Person
      first name: Olusegun A
      last name: Olanrewaju
      member of: Pure and Applied Biology, Ladoke Akintola University of Technology, Ogbomoso, NGA.General Medicine, Stavropol State Medical University, Stavropol, RUS.
  slot:
    index: 3
    item: Mahar K
      type: Person
      first name: Kinza
      last name: Mahar
      member of: Medicine, Bahria University Medical and Dental College, Karachi, PAK.
  slot:
    index: 4
    item: Israni M
      type: Person
      first name: Meena
      last name: Israni
      member of: Medicine, Sir Syed College of Medical Sciences, Karachi, PAK.
  slot:
    index: 5
    item: Bai R
      type: Person
      first name: Reena
      last name: Bai
      member of: Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.
  slot:
    index: 6
    item: Kumar N
      type: Person
      first name: Narendar
      last name: Kumar
      member of: Internal Medicine, Burjeel Hospital, Abu Dhabi, ARE.
  slot:
    index: 7
    item: Kumari K
      type: Person
      first name: Komal
      last name: Kumari
      member of: Medicine, NMC Royal Family Medical Centre, Abu Dhabi, ARE.
  slot:
    index: 8
    item: Shadmani S
      type: Person
      first name: Sujeet
      last name: Shadmani
      member of: Medicine, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, PAK.
  slot:
    index: 9
    item: Bashir MA
      type: Person
      first name: Muhammad Arsalan
      last name: Bashir
      member of: Medicine, Ziauddin University, Karachi, PAK.
  slot:
    index: 10
    item: Elharif M
      type: Person
      first name: Mostafa
      last name: Elharif
      member of: Medicine, Menoufia University, Shibin El Kom, EGY.
  slot:
    index: 11
    item: Varrassi G
      type: Person
      first name: Giustino
      last name: Varrassi
      member of: Pain Medicine, Paolo Procacci Foundation, Rome, ITA.
  slot:
    index: 12
    item: Kumar S
      type: Person
      first name: Satish
      last name: Kumar
      member of: Medicine, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, PAK.
  slot:
    index: 13
    item: Khatri M
      type: Person
      first name: Mahima
      last name: Khatri
      member of: Internal Medicine/Cardiology, Dow University of Health Sciences, Karachi, PAK.
  slot:
    index: 14
    item: Muzammil MA
      type: Person
      first name: Muhammad Ali
      last name: Muzammil
      member of: Internal Medicine, Dow University of Health Sciences, Karachi, PAK.
  slot:
    index: 15
    item: Sharma R
      type: Person
      first name: Roshan
      last name: Sharma
      member of: Medicine, Sanjay Gandhi Memorial Hospital, Delhi, IND.
  slot:
    index: 16
    item: Ullah F
      type: Person
      first name: Farhan
      last name: Ullah
      member of: Internal Medicine, Khyber Teaching Hospital, Peshawar, PAK.
created: 2024-1-30T06:42
date last updated: 2025-01-20
issued: 2023-12
dp: 2023 Dec
created: 2024-1-30T03:39
ISSN: 2168-8184
has issn l: 2168-8184
issue: 12
has NLM journal title abbreviation: Cureus
publication name: Cureus
language: eng
has national library of medicine journal id: 101596737
derived from: NLM
pg: e51256
has place of publication: United States
source: Cureus. 2023-12;15(12):e51256.
volume: 15

Loratadine as an Anti-inflammatory Agent Against Clostridium difficile Toxin B.
pmid: 38243838
abstract: Clostridium difficile infection (CDI) is a debilitating nosocomial infection. C. difficile produces toxins A and B, which cause inflammation. Existing therapies have issues with recurrence, cost, and safety. We aim to discover a safe, effective, and economical nonmicrobiological therapeutic approach against CDI.We included human primary peripheral blood mononuclear cells (PBMCs), fresh human colonic explants, and humanized HuCD34-NCG mice. Toxin A+B+ VPI 10463 and A-B+ ribotype 017 C. difficile strains were used. We used single-cell RNA profiling and high-throughput screening to find actionable toxin B-dependent pathways in PBMCs.Histamine 1 receptor-related drugs were found among the hit compounds that reversed toxin-mediated macrophage inflammatory protein (MIP) 1α expression in PBMCs. We identified loratadine as the safest representative antihistamine for therapeutic development. Loratadine inhibited toxin B-induced MIP-1α secretion in fresh human colonic tissues. Oral loratadine (10 mg/kg/d) maintained survival, inhibited intestinal CCl3 messenger RNA expression, and prevented vancomycin-associated recurrence in the VPI 10463-infected mice and ribotype 017-infected hamsters. Splenocytes from loratadine-treated mice conferred anti-inflammatory effects to the VPI 10463-infected T/B-cell--deficient Rag-/- mice. Oral loratadine suppressed human MIP-1α expression in monocytes/macrophages in toxin B-expressing ribotype 017-infected humanized HuCD34-NCG mice.Loratadine may be repurposed to optimize existing therapies against CDI.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7577993
doi: 10.1093/infdis/jiae021
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Xie Y
      type: Person
      first name: Ying
      last name: Xie
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.Department of Gastroenterology, The First Hospital of China Medical University, Shenyang City, China.
  slot:
    index: 2
    item: Irwin S
      type: Person
      first name: Sophie
      last name: Irwin
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
  slot:
    index: 3
    item: Chupina Estrada A
      type: Person
      first name: Andrea
      last name: Chupina Estrada
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
  slot:
    index: 4
    item: Nelson B
      type: Person
      first name: Becca
      last name: Nelson
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
  slot:
    index: 5
    item: Bullock A
      type: Person
      first name: Ashlen
      last name: Bullock
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
  slot:
    index: 6
    item: Fontenot L
      type: Person
      first name: Lindsey
      last name: Fontenot
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
  slot:
    index: 7
    item: Feng H
      type: Person
      first name: Hanping
      last name: Feng
      member of: Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.
  slot:
    index: 8
    item: Sun M
      type: Person
      first name: Mingjun
      last name: Sun
      member of: Department of Gastroenterology, The First Hospital of China Medical University, Shenyang City, China.
  slot:
    index: 9
    item: Koon HW
      type: Person
      first name: Hon Wai
      last name: Koon
      member of: Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
created: 2024-1-20T21:42
date last updated: 2025-01-20
issued: 2024-09-23
dp: 2024 Sep 23
created: 2024-1-20T09:07
e ISSN: 1537-6613
has issn l: 0022-1899
issue: 3
has NLM journal title abbreviation: J Infect Dis
publication name: The Journal of infectious diseases
language: eng
has national library of medicine journal id: 0413675
rights holder: Loratadine, a Food and Drug Administration–approved antihistamine, inhibits toxin B–mediated proinflammatory macrophage inflammatory protein 1α secretion from immune cells. Its anti-inflammatory effect ameliorates intestinal inflammation in Clostridium difficile–infected animals. Loratadine may be repurposed to optimize existing therapies.
derived from: NLM
starting page: 545
ending page: 557
has place of publication: United States
has primary subject term: D016360Q000187
has primary subject term: D000893Q000494
has primary subject term: D017336Q000494
has primary subject term: D007963Q000187Q000378
has primary subject term: D001427
has primary subject term: D001426Q000378
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D003015Q000188
has subject term: D003106Q000187Q000382Q000378
has subject term: D004768
has subject term: D054405Q000378
source: J Infect Dis. 2024-09-23;230(3):545-557.
volume: 230

Biorobotic hybrid heart as a benchtop cardiac mitral valve simulator.
pmid: 38312504
abstract: In this work, we developed a high-fidelity beating heart simulator that provides accurate mitral valve pathophysiology. The benchtop platform is based on a biorobotic hybrid heart that combines preserved intracardiac tissue with soft robotic cardiac muscle providing dynamic left ventricular motion and precise anatomical features designed for testing intracardiac devices, particularly for mitral valve repair. The heart model is integrated into a mock circulatory loop, and the active myocardium drives fluid circulation producing physiological hemodynamics without an external pulsatile pump. Using biomimetic soft robotic technology, the heart can replicate both ventricular and septal wall motion, as well as intraventricular pressure-volume relationships. This enables the system to recreate the natural motion and function of the mitral valve, which allows us to demonstrate various surgical and interventional techniques. The biorobotic cardiovascular simulator allows for real-time hemodynamic data collection, direct visualization of the intracardiac procedure, and compatibility with clinical imaging modalities.
doi: 10.1016/j.device.2023.100217
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Park C
      type: Person
      first name: Clara
      last name: Park
      member of: Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, MA, USA 02139.Department of Mechanical Engineering, Massachusetts Institute of Technology; Cambridge, MA, USA 02139.
  slot:
    index: 2
    item: Singh M
      type: Person
      first name: Manisha
      last name: Singh
      member of: Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, MA, USA 02139.
  slot:
    index: 3
    item: Saeed MY
      type: Person
      first name: Mossab Y
      last name: Saeed
      member of: Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA 02115.
  slot:
    index: 4
    item: Nguyen CT
      type: Person
      first name: Christopher T
      last name: Nguyen
      member of: Cardiovascular Research Center, Massachusetts General Hospital; Charlestown, MA, USA 02114.Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic; Cleveland, OH, USA 44195.Imaging Sciences, Imaging Institute, Cleveland Clinic; Cleveland, OH, USA 44195.Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic; Cleveland, OH, USA 44196.
  slot:
    index: 5
    item: Roche ET
      type: Person
      first name: Ellen T
      last name: Roche
      member of: Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, MA, USA 02139.Department of Mechanical Engineering, Massachusetts Institute of Technology; Cambridge, MA, USA 02139.
created: 2024-2-5T06:43
date last updated: 2025-01-20
issued: 2024-01-19
dp: 2024 Jan 19
created: 2024-2-5T04:20
e ISSN: 2666-9986
has issn l: 2666-9986
issue: 1
has NLM journal title abbreviation: Device
publication name: Device
language: eng
has national library of medicine journal id: 9918646081706676
derived from: NLM
has place of publication: United States
source: Device. 2024-01-19;2(1):.
volume: 2

Can patient anthropometry predict the anterior cruciate ligament footprint dimensions? - An MRI-based observational study on north Indian population.
pmid: 38323077
abstract: Anterior Cruciate Ligament (ACL) reconstruction is one of the most common surgeries being currently done. As we usher into the era of Individualized Anatomic Reconstruction, it is very important to understand the native anatomy of ACL. We aimed to assess the ACL footprint dimensions in our patients and correlate it with anthropometric variables, which can help in preoperative decision making.A total of 143 eligible patients with suspected ACL injury presented during the study period. Out of which 92 were included in the study. Data on patient's age, sex, height, weight and body mass index (BMI) was recorded. The length and area of both the tibial and femoral footprints were measured on MRI. The footprint dimensions were correlated with the recorded anthropometric data.The ACL tibial footprint length and area, and femoral footprint length and area were found to be 13.3 ± 2.23 mm, 142.6 ± 26.16 mm2, 11.2 ± 1.97 mm, 125.8 ± 28.75 mm2 respectively. Footprint in males was significantly larger than females. A weak (ρ- 0.21 to 0.4) correlation with weight and moderate (ρ- 0.41 to 0.6) correlation with height was observed. Multivariate linear regression analysis yielded height to be the only significant predictor of footprint dimension from which predictive equations were drawn.Height was found to be the most significant predictor of footprint dimensions in our patients. The predictive equations and graphs can aid in preoperative surgical decision making resulting in a more anatomical ACL reconstruction and improve the post-operative results.
has PII: S0976-5662(24)00010-9
doi: 10.1016/j.jcot.2024.102341
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Gupta K
      type: Person
      first name: Kshitij
      last name: Gupta
      member of: Department of Orthopaedics, All India Institute of Medical Sciences, Veerbhadra Road, Rishikesh, Uttarakhand, 249203, India.
  slot:
    index: 2
    item: Choudhury AK
      type: Person
      first name: Arghya Kundu
      last name: Choudhury
      member of: Department of Orthopaedics, All India Institute of Medical Sciences, Veerbhadra Road, Rishikesh, Uttarakhand, 249203, India.
  slot:
    index: 3
    item: Raja BS
      type: Person
      first name: Balgovind S
      last name: Raja
      member of: Department of Orthopaedics, All India Institute of Medical Sciences, Veerbhadra Road, Rishikesh, Uttarakhand, 249203, India.
  slot:
    index: 4
    item: Chandra A
      type: Person
      first name: Abhishek
      last name: Chandra
      member of: Department of Trauma Surgery, All India Institute of Medical Sciences, Veerbhadra Road, Rishikesh, Uttarakhand, 249203, India.
  slot:
    index: 5
    item: Azam MQ
      type: Person
      first name: Md Quamar
      last name: Azam
      member of: Department of Trauma Surgery, All India Institute of Medical Sciences, Veerbhadra Road, Rishikesh, Uttarakhand, 249203, India.
  slot:
    index: 6
    item: Kalia RB
      type: Person
      first name: Roop Bhushan
      last name: Kalia
      member of: Department of Orthopaedics, All India Institute of Medical Sciences, Veerbhadra Road, Rishikesh, Uttarakhand, 249203, India.
created: 2024-2-7T06:41
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-2-7T04:12
ISSN: 0976-5662
has issn l: 0976-5662
has NLM journal title abbreviation: J Clin Orthop Trauma
publication name: Journal of clinical orthopaedics and trauma
language: eng
has national library of medicine journal id: 101559469
derived from: NLM
pg: 102341
has place of publication: India
source: J Clin Orthop Trauma. 2024-02;49():102341.
volume: 49

Neurodevelopmental assessments used to measure preschoolers' cognitive development in Latin America: a systematic review.
pmid: 38244996
abstract: The objective of this study was to systematically review the standardized neurodevelopmental assessments used to study preschool-aged children's cognitive development in Spanish-speaking Latin America.The authors systematically searched PubMed, PsycINFO, and ERIC databases for peer-reviewed articles from Spanish-speaking Latin American countries. Articles were included if they measured cognitive development among children aged 2-6 years using at least one standardized assessment tool; 97 articles were included and reviewed in accordance with PRISMA guidelines to assess their use of these tools.Ninety-seven studies across 13 countries used a total of 41 assessments to measure cognitive development; most widely used were the Wechsler intelligence scales (n = 46/97), particularly the Wechsler Preschool and Primary Scale of Intelligence and Wechsler Intelligence Scale for Children (n = 23 and 29, respectively). Other common assessments included the McCarthy Scales of Children's Abilities (n = 9), Raven's Progressive Matrices (n = 9), Child Neuropsychological Assessment (n = 8), and Peabody Picture Vocabulary Test (n = 7). In regions where normative data for a given assessment were unpublished, authors commonly used norms from the United States, Mexico, or Spain or did not report standard scores in their analyses.The wide range of tools used in these studies presents a challenge for generalizing results when measuring the neurodevelopment of Latin American preschool-aged children. The low availability of normative data for specific regions reveals concerns if some tools are culturally and linguistically appropriate even when Spanish is a common language, particularly in low-resource settings. Future work to forge greater consistency in the use of validated measures, clarity in reporting research methods, and publication of regional normative data would benefit the field.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
has PII: 7582081
doi: 10.1093/jpepsy/jsad089
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Williams ME
      type: Person
      first name: Meagan E
      last name: Williams
      member of: Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.
  slot:
    index: 2
    item: Corn EA
      type: Person
      first name: Elizabeth A
      last name: Corn
      member of: Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.
  slot:
    index: 3
    item: Martinez Ransanz S
      type: Person
      first name: Santiago
      last name: Martinez Ransanz
      member of: Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.Department of Emergency Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
  slot:
    index: 4
    item: Berl MM
      type: Person
      first name: Madison M
      last name: Berl
      member of: Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.Department of Psychiatry and Behavioral Sciences, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
  slot:
    index: 5
    item: Andringa-Seed R
      type: Person
      first name: Regan
      last name: Andringa-Seed
      member of: Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.
  slot:
    index: 6
    item: Mulkey SB
      type: Person
      first name: Sarah B
      last name: Mulkey
      member of: Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, United States.Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
created: 2024-1-21T00:42
date last updated: 2025-01-20
issued: 2024-05-16
dp: 2024 May 16
created: 2024-1-20T20:13
e ISSN: 1465-735X
has issn l: 0146-8693
issue: 5
has NLM journal title abbreviation: J Pediatr Psychol
publication name: Journal of pediatric psychology
language: eng
has national library of medicine journal id: 7801773
derived from: NLM
starting page: 321
ending page: 339
has place of publication: United States
has primary subject term: D002657Q000502
has primary subject term: D003071
has subject term: D006801
has subject term: D007843
has subject term: D002675
has subject term: D002648
has subject term: D009483Q000592Q000706
source: J Pediatr Psychol. 2024-05-16;49(5):321-339.
volume: 49

Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity.
pmid: 38357286
abstract: Cathepsins (Cats) are proteases that mediate the successful entry of SARS-CoV-2 into host cells. We designed and synthesized a tailored series of 21 peptidomimetics and evaluated their inhibitory activity against human cathepsins L, B, and S. Structural diversity was realized by combinations of different C-terminal warhead functions and N-terminal capping groups, while a central Leu-Phe fragment was maintained. Several compounds were identified as promising cathepsin L and S inhibitors with Ki values in the low nanomolar to subnanomolar range, for example, the peptide aldehydes 9a and 9b (9a, 2.67 nM, CatL; 0.455 nM, CatS; 9b, 1.76 nM, CatL; 0.512 nM, CatS). The compounds' inhibitory activity against the main protease of SARS-CoV-2 (Mpro) was additionally investigated. Based on the results at CatL, CatS, and Mpro, selected inhibitors were subjected to investigations of their antiviral activity in cell-based assays. In particular, the peptide nitrile 11e exhibited promising antiviral activity with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity. High metabolic stability and favorable pharmacokinetic properties make 11e suitable for further preclinical development.
rights: © 2024 American Chemical Society.
doi: 10.1021/acsptsci.3c00313
creator: OrderedList
  length: 21
  slot:
    index: 1
    item: Flury P
      type: Person
      first name: Philipp
      last name: Flury
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.
  slot:
    index: 2
    item: Breidenbach J
      type: Person
      first name: Julian
      last name: Breidenbach
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 3
    item: Krüger N
      type: Person
      first name: Nadine
      last name: Krüger
      member of: Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany.
  slot:
    index: 4
    item: Voget R
      type: Person
      first name: Rabea
      last name: Voget
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 5
    item: Schäkel L
      type: Person
      first name: Laura
      last name: Schäkel
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 6
    item: Si Y
      type: Person
      first name: Yaoyao
      last name: Si
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 7
    item: Krasniqi V
      type: Person
      first name: Vesa
      last name: Krasniqi
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 8
    item: Calistri S
      type: Person
      first name: Sara
      last name: Calistri
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.
  slot:
    index: 9
    item: Olfert M
      type: Person
      first name: Matthias
      last name: Olfert
      member of: Faculty of Biology and Psychology, University Göttingen, Göttingen 37073, Germany.
  slot:
    index: 10
    item: Sylvester K
      type: Person
      first name: Katharina
      last name: Sylvester
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 11
    item: Rocha C
      type: Person
      first name: Cheila
      last name: Rocha
      member of: Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany.
  slot:
    index: 12
    item: Ditzinger R
      type: Person
      first name: Raphael
      last name: Ditzinger
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.
  slot:
    index: 13
    item: Rasch A
      type: Person
      first name: Alexander
      last name: Rasch
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.
  slot:
    index: 14
    item: Pöhlmann S
      type: Person
      first name: Stefan
      last name: Pöhlmann
      member of: Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research Göttingen, Kellnerweg 4, Göttingen 37077, Germany.Faculty of Biology and Psychology, University Göttingen, Göttingen 37073, Germany.
  slot:
    index: 15
    item: Kronenberger T
      type: Person
      first name: Thales
      last name: Kronenberger
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.Excellence Cluster Controlling Microbes to Fight Infections (CMFI), Tübingen 72076, Germany.
  slot:
    index: 16
    item: Poso A
      type: Person
      first name: Antti
      last name: Poso
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.
  slot:
    index: 17
    item: Rox K
      type: Person
      first name: Katharina
      last name: Rox
      member of: Department of Chemical Biology, Helmholtz Centre for Infection Research (HZI), Braunschweig 38124, Germany.Partner Site Hannover-Braunschweig, German Center for Infection Research (DZIF), Braunschweig 38124, Germany.
  slot:
    index: 18
    item: Laufer SA
      type: Person
      first name: Stefan A
      last name: Laufer
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.
  slot:
    index: 19
    item: Müller CE
      type: Person
      first name: Christa E
      last name: Müller
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 20
    item: Gütschow M
      type: Person
      first name: Michael
      last name: Gütschow
      member of: PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.
  slot:
    index: 21
    item: Pillaiyar T
      type: Person
      first name: Thanigaimalai
      last name: Pillaiyar
      member of: Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany.
created: 2024-2-15T06:43
date last updated: 2025-01-20
issued: 2024-02-09
dp: 2024 Feb 09
created: 2024-2-15T04:19
e ISSN: 2575-9108
has issn l: 2575-9108
issue: 2
has NLM journal title abbreviation: ACS Pharmacol Transl Sci
publication name: ACS pharmacology & translational science
language: eng
has national library of medicine journal id: 101721411
derived from: NLM
starting page: 493
ending page: 514
has place of publication: United States
source: ACS Pharmacol Transl Sci. 2024-02-09;7(2):493-514.
volume: 7

Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma.
pmid: 38373993
abstract: Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using whole genome bisulfite sequencing (WGBS), we identify the transcription factor (TF) FOXM1 as an important epigenetic regulator of EAC. FOXM1 plays a critical role in cellular proliferation and tumor growth in EAC patient-derived organoids and cell line models. We identify ERBB2 as an upstream regulator of the expression and transcriptional activity of FOXM1. Unexpectedly, gene set enrichment analysis (GSEA) unbiased screen reveals a prominent anti-correlation between FOXM1 and immune response pathways. Indeed, syngeneic mouse models show that FOXM1 inhibits the infiltration of CD8+ T cells into the tumor microenvironment. Consistently, FOXM1 suppresses CD8+ T cell chemotaxis in vitro and antigen-dependent CD8+ T cell killing. This study characterizes FOXM1 as a significant EAC-promoting TF and elucidates its novel function in regulating anti-tumor immune response.
rights: © 2024. The Author(s).
has PII: 10.1038/s41419-024-06488-x
doi: 10.1038/s41419-024-06488-x
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Ziman B
      type: Person
      first name: Benjamin
      last name: Ziman
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St, Los Angeles, CA, 90089, USA.Department of Otolaryngology Head and Neck, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA, 90033, USA.
  slot:
    index: 2
    item: Yang Q
      type: Person
      first name: Qian
      last name: Yang
      member of: Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Cedars-Sinai Medical Center, 127S. San Vicente Blvd, Los Angeles, CA, 90048, USA.
  slot:
    index: 3
    item: Zheng Y
      type: Person
      first name: Yueyuan
      last name: Zheng
      member of: Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Cedars-Sinai Medical Center, 127S. San Vicente Blvd, Los Angeles, CA, 90048, USA.
  slot:
    index: 4
    item: Sheth M
      type: Person
      first name: Megha
      last name: Sheth
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St, Los Angeles, CA, 90089, USA.
  slot:
    index: 5
    item: Nam C
      type: Person
      first name: Chehyun
      last name: Nam
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St, Los Angeles, CA, 90089, USA.
  slot:
    index: 6
    item: Zhao H
      type: Person
      first name: Hua
      last name: Zhao
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St, Los Angeles, CA, 90089, USA.
  slot:
    index: 7
    item: Zhang L
      type: Person
      first name: Le
      last name: Zhang
      member of: Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Cedars-Sinai Medical Center, 127S. San Vicente Blvd, Los Angeles, CA, 90048, USA.
  slot:
    index: 8
    item: Hu B
      type: Person
      first name: Boyan
      last name: Hu
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St, Los Angeles, CA, 90089, USA.
  slot:
    index: 9
    item: Bhowmick NA
      type: Person
      first name: Neil A
      last name: Bhowmick
      member of: Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Cedars-Sinai Medical Center, 127S. San Vicente Blvd, Los Angeles, CA, 90048, USA.
  slot:
    index: 10
    item: Sinha UK
      type: Person
      first name: Uttam K
      last name: Sinha
      member of: Department of Otolaryngology Head and Neck, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA, 90033, USA. sinha@med.usc.edu.
  slot:
    index: 11
    item: Lin DC
      type: Person
      first name: De-Chen
      last name: Lin
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St, Los Angeles, CA, 90089, USA. dechenli@usc.edu.Department of Otolaryngology Head and Neck, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA, 90033, USA. dechenli@usc.edu.
created: 2024-2-20T11:50
date last updated: 2025-01-20
issued: 2024-02-19
dp: 2024 02 19
created: 2024-2-19T23:38
e ISSN: 2041-4889
issue: 2
has NLM journal title abbreviation: Cell Death Dis
publication name: Cell death & disease
language: eng
has national library of medicine journal id: 101524092
derived from: NLM
pg: 152
has place of publication: England
has primary subject term: D000230Q000235Q000276Q000473
has primary subject term: D018414Q000378
has primary subject term: D004938Q000235Q000276
has primary subject term: D000072278Q000235Q000378
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D045744
has subject term: D049109
has subject term: D057890
has subject term: D015972
has subject term: D007109
has subject term: D059016Q000276
source: Cell Death Dis. 2024-02-19;15(2):152.
volume: 15

Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.
pmid: 38380882
abstract: Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's disease (DIAD) presenilin-1 (PSEN1) mutation carriers. We investigated how mutation position relative to codon 200 (pre-/postcodon 200) influences these pathologic features and dementia at different stages.Individuals from families with known PSEN1 mutations (n = 393) underwent neuroimaging and clinical assessments. We cross-sectionally evaluated regional Pittsburgh compound B-positron emission tomography uptake, magnetic resonance imaging markers of SVD (diffusion tensor imaging-based white matter injury, white matter hyperintensity volumes, and microhemorrhages), and cognition.Postcodon 200 carriers had lower amyloid burden in all regions but worse markers of SVD and worse Clinical Dementia Rating® scores compared to precodon 200 carriers as a function of estimated years to symptom onset. Markers of SVD partially mediated the mutation position effects on clinical measures.We demonstrated the genotypic variability behind spatiotemporal amyloidosis, SVD, and clinical presentation in DIAD, which may inform patient prognosis and clinical trials.Mutation position influences Aβ burden, SVD, and dementia. PSEN1 pre-200 group had stronger associations between Aβ burden and disease stage. PSEN1 post-200 group had stronger associations between SVD markers and disease stage. PSEN1 post-200 group had worse dementia score than pre-200 in late disease stage. Diffusion tensor imaging-based SVD markers mediated mutation position effects on dementia in the late stage.
rights: © 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
doi: 10.1002/alz.13729
creator: OrderedList
  length: 58
  slot:
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    item: Joseph-Mathurin N
      type: Person
      first name: Nelly
      last name: Joseph-Mathurin
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 2
    item: Feldman RL
      type: Person
      first name: Rebecca L
      last name: Feldman
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 3
    item: Lu R
      type: Person
      first name: Ruijin
      last name: Lu
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 4
    item: Shirzadi Z
      type: Person
      first name: Zahra
      last name: Shirzadi
      member of: Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 5
    item: Toomer C
      type: Person
      first name: Carmen
      last name: Toomer
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  slot:
    index: 6
    item: Saint Clair JR
      type: Person
      first name: Junie R
      last name: Saint Clair
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.Meharry School of Medicine, Meharry College, Nashville, Tennessee, USA.
  slot:
    index: 7
    item: Ma Y
      type: Person
      first name: Yinjiao
      last name: Ma
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 8
    item: McKay NS
      type: Person
      first name: Nicole S
      last name: McKay
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 9
    item: Strain JF
      type: Person
      first name: Jeremy F
      last name: Strain
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 10
    item: Kilgore C
      type: Person
      first name: Collin
      last name: Kilgore
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 11
    item: Friedrichsen KA
      type: Person
      first name: Karl A
      last name: Friedrichsen
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 12
    item: Chen CD
      type: Person
      first name: Charles D
      last name: Chen
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 13
    item: Gordon BA
      type: Person
      first name: Brian A
      last name: Gordon
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 14
    item: Chen G
      type: Person
      first name: Gengsheng
      last name: Chen
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 15
    item: Hornbeck RC
      type: Person
      first name: Russ C
      last name: Hornbeck
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 16
    item: Massoumzadeh P
      type: Person
      first name: Parinaz
      last name: Massoumzadeh
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 17
    item: McCullough AA
      type: Person
      first name: Austin A
      last name: McCullough
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 18
    item: Wang Q
      type: Person
      first name: Qing
      last name: Wang
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 19
    item: Li Y
      type: Person
      first name: Yan
      last name: Li
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 20
    item: Wang G
      type: Person
      first name: Guoqiao
      last name: Wang
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 21
    item: Keefe SJ
      type: Person
      first name: Sarah J
      last name: Keefe
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 22
    item: Schultz SA
      type: Person
      first name: Stephanie A
      last name: Schultz
      member of: Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  slot:
    index: 23
    item: Cruchaga C
      type: Person
      first name: Carlos
      last name: Cruchaga
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 24
    item: Preboske GM
      type: Person
      first name: Gregory M
      last name: Preboske
      member of: Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 25
    item: Jack CR
      type: Person
      first name: Clifford R
      last name: Jack
      member of: Mayo Clinic, Rochester, Minnesota, USA.
  slot:
    index: 26
    item: Llibre-Guerra JJ
      type: Person
      first name: Jorge J
      last name: Llibre-Guerra
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
  slot:
    index: 27
    item: Allegri RF
      type: Person
      first name: Ricardo F
      last name: Allegri
      member of: Institute for Neurological Research FLENI, Montañeses, Buenos Aires, Argentina.
  slot:
    index: 28
    item: Ances BM
      type: Person
      first name: Beau M
      last name: Ances
      member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.
creator: Dominantly Inherited Alzheimer Network
created: 2024-2-21T12:42
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 04
created: 2024-2-21T08:33
e ISSN: 1552-5279
has issn l: 1552-5260
issue: 4
has NLM journal title abbreviation: Alzheimers Dement
publication name: Alzheimer's & dementia : the journal of the Alzheimer's Association
language: eng
has national library of medicine journal id: 101231978
derived from: NLM
starting page: 2680
ending page: 2697
has place of publication: United States
has primary subject term: D000544Q000000981Q000235Q000473
has primary subject term: D000686
has primary subject term: D059345Q000000981Q000235Q000150
has subject term: D006801
has subject term: D056324
has subject term: D008279
has subject term: D009154Q000235
has subject term: D053764Q000235
source: Alzheimers Dement. 2024-04;20(4):2680-2697.
volume: 20

Harnessing Transfer Learning for Dementia Prediction: Leveraging Sex-Different Mild Cognitive Impairment Prognosis.
pmid: 38404694
abstract: This paper presents a machine learning-based prediction for dementia, leveraging transfer learning to reuse the knowledge learned from prediction of mild cognitive impairment, a precursor of dementia. We also examine the impacts of temporal aspects of longitudinal data and sex differences. The methodology encompasses key components such as setting the duration window, comparing different modeling strategies, conducting comprehensive evaluations, and examining the sex-specific impacts of simulated scenarios. The findings reveal that cognitive deficits in females, once detected at the mild cognitive impairment stage, tend to deteriorate over time, while males exhibit more diverse decline across various characteristics without highlighting specific ones. However, the underlying reasons for these sex differences remain unknown and warrant further investigation.
doi: 10.1109/bibm58861.2023.10385516
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Liu Z
      type: Person
      first name: Ziming
      last name: Liu
      member of: Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, USA.
  slot:
    index: 2
    item: Garg M
      type: Person
      first name: Muskan
      last name: Garg
      member of: Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
  slot:
    index: 3
    item: Fu S
      type: Person
      first name: Sunyang
      last name: Fu
      member of: Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
  slot:
    index: 4
    item: Sarkar S
      type: Person
      first name: Surjodeep
      last name: Sarkar
      member of: Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
  slot:
    index: 5
    item: Vassilaki M
      type: Person
      first name: Maria
      last name: Vassilaki
      member of: Department of Quantitative Health Sciences, Mayo Clinic, Rochester, USA.
  slot:
    index: 6
    item: Petersen RC
      type: Person
      first name: Ronald C
      last name: Petersen
      member of: Department of Neurology, Mayo Clinic, Rochester, USA.
  slot:
    index: 7
    item: St Sauver J
      type: Person
      first name: Jennifer
      last name: St Sauver
      member of: Department of Quantitative Health Sciences, Mayo Clinic, Rochester, USA.
  slot:
    index: 8
    item: Sohn S
      type: Person
      first name: Sunghwan
      last name: Sohn
      member of: Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
created: 2024-2-26T06:42
date last updated: 2025-01-20
issued: 2023-12
dp: 2023 Dec
created: 2024-2-26T04:31
ISSN: 2156-1125
has issn l: 2156-1125
has NLM journal title abbreviation: Proceedings (IEEE Int Conf Bioinformatics Biomed)
publication name: Proceedings. IEEE International Conference on Bioinformatics and Biomedicine
language: eng
has national library of medicine journal id: 101525347
derived from: NLM
starting page: 2097
ending page: 2100
has place of publication: United States
source: Proceedings (IEEE Int Conf Bioinformatics Biomed). 2023-12;2023():2097-2100.
volume: 2023

Potentially toxic elements contamination in the water resources: an integrated risk assessment approach in the upper Citarum watershed area.
pmid: 38367034
abstract: The Citarum watershed is West Java Province's most important water resource; hence, harmful compounds should be monitored regularly. This study assessed pollution levels along with ecological and health risks from Cd, Pb, Mn, Fe, Cu, Cr, and Hg contamination in river water, sediment, groundwater, and soil in Citarum's upper watershed. In river water, the average amounts of Cd, Pb, Mn, Fe, Cu, Cr, and Hg were 0.002, 0.05, 0.092, 0.649, 0.022, 0.001, and 0.421 mg/L. In sediment, they were 7.4, 1175.1, 32,289.9, 37.3, 3.9, and 0.015 mg/kg. The mean concentrations of Cd, Pb, Mn, Fe, Cu, Cr, and Hg in groundwater were 0.004, 0.046, 0.567, 0.366, 0.019, 0.001, and 0.177 mg/L, and in soil, BDL, 10.2, 744.6, 50,094.1, 45.6, 5.9, and 0.015 mg/kg. The river water and groundwater were highly polluted by PTEs, with HPI values of 14,733 and 933, respectively. While PTEs pollution levels and risk in sediment and soil were low based on I-geo, CF, PLI, and M-ERM-Q values, PTEs contamination in river water may cause adverse impacts on aquatic living organisms (HQ > 1). The population doing recreational activities in river ecosystems was still safe from non-carcinogenic and carcinogenic impacts due to PTEs exposure from river water and sediment (THI < 1 and TCR value < 1E-04), while the population in the upper Citarum River was not safe from the carcinogenic risk due to PTE exposure from groundwater and soil (TCR > 1E-04). The sensitivity analysis showed that Cd concentration in groundwater is the most influential factor in cancer risk, with a total contribution of 99.9%. Therefore, a reduction in Cd concentration in groundwater is important to reduce cancer risk in the population.
rights: © 2024. The Author(s), under exclusive licence to Springer Nature B.V.
has PII: 10.1007/s10653-023-01818-y
doi: 10.1007/s10653-023-01818-y
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Astuti RDP
      type: Person
      first name: Ratna Dwi Puji
      last name: Astuti
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia. ratna.dwi@fkm.unair.ac.id.Faculty of Public Health, Universitas Airlangga, Surabaya, 60155, Indonesia. ratna.dwi@fkm.unair.ac.id.
  slot:
    index: 2
    item: Maria R
      type: Person
      first name: Rizka
      last name: Maria
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia. rizk002@brin.go.id.
  slot:
    index: 3
    item: Nurohman H
      type: Person
      first name: Heri
      last name: Nurohman
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia.
  slot:
    index: 4
    item: Shoedarto RM
      type: Person
      first name: Riostantieka Mayandari
      last name: Shoedarto
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia.
  slot:
    index: 5
    item: Rusydi AF
      type: Person
      first name: Anna Fadliah
      last name: Rusydi
      member of: Research Center for Limnology and Water Resources, National Research and Innovation Agency, Cibinong, 16911, Indonesia.
  slot:
    index: 6
    item: Marganingrum D
      type: Person
      first name: Dyah
      last name: Marganingrum
      member of: Research Center for Environmental and Clean Technology, National Research and Innovation Agency, Bandung, 40135, Indonesia.
  slot:
    index: 7
    item: Damayanti R
      type: Person
      first name: Retno
      last name: Damayanti
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia.
  slot:
    index: 8
    item: Mulyono A
      type: Person
      first name: Asep
      last name: Mulyono
      member of: Research Center for Environmental and Clean Technology, National Research and Innovation Agency, Bandung, 40135, Indonesia.
  slot:
    index: 9
    item: Rahayudin Y
      type: Person
      first name: Yudi
      last name: Rahayudin
      member of: Polytechnic of Energy and Mining, Ministry of Energy and Mineral Resources, Bandung, 40211, Indonesia.
  slot:
    index: 10
    item: Dida EN
      type: Person
      first name: Eki Naidania
      last name: Dida
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia.
  slot:
    index: 11
    item: Yuliyanti A
      type: Person
      first name: Anita
      last name: Yuliyanti
      member of: Research Center for Geological Resources, National Research and Innovation Agency, Bandung, 40135, Indonesia.
created: 2024-2-17T21:42
date last updated: 2025-01-20
issued: 2024-02-17
dp: 2024 Feb 17
created: 2024-2-17T11:03
e ISSN: 1573-2983
has issn l: 0269-4042
issue: 3
has NLM journal title abbreviation: Environ Geochem Health
publication name: Environmental geochemistry and health
language: eng
has national library of medicine journal id: 8903118
derived from: NLM
pg: 77
has place of publication: Netherlands
has primary subject term: D019216Q000633Q000032
has primary subject term: D008628Q000032
has primary subject term: D009369
has subject term: D006801
has subject term: D017753
has subject term: D004784
has subject term: D014867Q000032
has subject term: D002104Q000032
has subject term: D007854Q000032
has subject term: D045483
has subject term: D018570
has subject term: D012987
has subject term: D011948
has subject term: D002681
source: Environ Geochem Health. 2024-02-17;46(3):77.
volume: 46

Navigating Sex-Specific Disease Dynamics in Incident Dementia.
pmid: 38404695
abstract: Dementia is among the leading causes of cognitive and functional loss and disability in older adults. Past studies suggested sex differences in health conditions and progression of cognitive decline. Existing studies on the temporal trajectory of health conditions for patient characterization after dementia diagnosis are scarce and ambiguous. Thus, there's limited and unclear research on how health conditions change over time after a dementia diagnosis. To this end, we aim to analyze the shift in medical conditions and examine sex-specific changes in patterns of chronic health conditions after dementia diagnosis. We centered our analysis on a 15-year window around the point of dementia diagnosis, encompassing the 5 years leading up to the diagnosis and the 10 years following it. We introduce (i) MedMet, a network metric to quantify the contribution of each medical condition, and (ii) growth and decay function for temporal trajectory analysis of medical conditions. Our experiments demonstrate that certain health conditions are more prevalent among females than males. Thus, our findings underscore the pressing need to examine differences between men and women, which could be important for healthcare utilization after a dementia diagnosis.
doi: 10.1109/bibm58861.2023.10385324
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Garg M
      type: Person
      first name: Muskan
      last name: Garg
      member of: Artificial Intelligence & Informatics, Mayo Clinic, Rochester, MN, USA.
  slot:
    index: 2
    item: Liu X
      type: Person
      first name: Xingyi
      last name: Liu
      member of: Artificial Intelligence & Informatics, Mayo Clinic, Rochester, MN, USA.
  slot:
    index: 3
    item: Vassilaki M
      type: Person
      first name: Maria
      last name: Vassilaki
      member of: Quantitative Health Science Research, Mayo Clinic, Rochester, MN, USA.
  slot:
    index: 4
    item: Petersen RC
      type: Person
      first name: Ronald C
      last name: Petersen
      member of: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  slot:
    index: 5
    item: St Sauver J
      type: Person
      first name: Jennifer
      last name: St Sauver
      member of: Quantitative Health Science Research, Mayo Clinic, Rochester, MN, USA.
  slot:
    index: 6
    item: Sohn S
      type: Person
      first name: Sunghwan
      last name: Sohn
      member of: Artificial Intelligence & Informatics, Mayo Clinic, Rochester, MN, USA.
created: 2024-2-26T06:43
date last updated: 2025-01-20
issued: 2023-12
dp: 2023 Dec
created: 2024-2-26T04:31
ISSN: 2156-1125
has issn l: 2156-1125
has NLM journal title abbreviation: Proceedings (IEEE Int Conf Bioinformatics Biomed)
publication name: Proceedings. IEEE International Conference on Bioinformatics and Biomedicine
language: eng
has national library of medicine journal id: 101525347
derived from: NLM
starting page: 4065
ending page: 4072
has place of publication: United States
source: Proceedings (IEEE Int Conf Bioinformatics Biomed). 2023-12;2023():4065-4072.
volume: 2023

Systematic methodological review of health state values in glaucoma cost-utility analyses.
pmid: 38411844
abstract: Describing the characteristics and sources of health state utility values and reporting practice in the literature of cost-utility analyses facilitates an understanding of the level of the transparency, validity, and generalizability of cost-utility analyses. Improving the quality of reporting will support investigators in describing the incremental value of emerging glaucoma interventions.To describe the state of practice among published glaucoma cost-utility analysis studies, focusing on valuation of health and the quality of reporting.We searched several databases including Medline, CINHAL, Embase, Web of Science, Scopus, Biosis previews, the Health Economic Evaluations Database, and the NHS Economic Evaluation Database (NHS EED). We included full-text, English, published cost-utility analyses of glaucoma interventions with quality-adjusted life years (QALYs) as the primary outcome measure to calculate incremental cost-utility ratios. Excluded studies were non-English language, reviews, editorials, protocols, or other types of economic studies (cost-benefit, cost-minimization, cost-effectiveness). Study characteristics, operational definitions of glaucoma health states and health state utilities were extracted. The original source of the health utility was reviewed to determine the scale of measurement and the source of preference weighting. Items from the Systematic Review of Utilities for Cost-Effectiveness (SpRUCE checklist) were used to assess the reporting and quality of health utilities in glaucoma CUA.43 CUAs were included, with 11 unique sources of health utilities. A wide range of health utilities for the same Hodapp-Parrish-Anderson glaucoma health states were reported; ocular hypertension (0.84-0.95), mild (0.68-0.94), moderate (0.57-0.92), advanced (0.58-0.88), severe/blind (0.46-0.76), and bilateral blindness (0.26-0.5). Most studies reported the basis for using health utilities (34, 79%) and any assumptions or adjustments applied to the health utili[cell cut: 2861 characters, first 2000 kept]
rights: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
has PII: 10.1007/s10198-023-01663-x
doi: 10.1007/s10198-023-01663-x
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Kennedy K
      type: Person
      first name: Kevin
      last name: Kennedy
      member of: School of Population and Public Health, University of British Columbia, 2206 E Mall, Vancouver, BC, V6T1Z3, Canada. kevin.kennedy@ubc.ca.
  slot:
    index: 2
    item: Sarohia G
      type: Person
      first name: Gurkaran
      last name: Sarohia
      member of: Department of Ophthalmology and Visual Sciences, University of Alberta, 400, 10924, 107 Avenue, Edmonton, AB, T5H 0X5, Canada.
  slot:
    index: 3
    item: Podbielski D
      type: Person
      first name: Dominik
      last name: Podbielski
      member of: Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
  slot:
    index: 4
    item: Pickard S
      type: Person
      first name: Simon
      last name: Pickard
      member of: College of Pharmacy-Pharmacy Systems Outcomes and Policy, University of Illinois Chicago, Chicago, USA.
  slot:
    index: 5
    item: Tarride JE
      type: Person
      first name: Jean-Eric
      last name: Tarride
      member of: Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
  slot:
    index: 6
    item: Xie F
      type: Person
      first name: Feng
      last name: Xie
      member of: Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
created: 2024-2-27T12:42
date last updated: 2025-01-19
issued: 2024-11
dp: 2024 Nov
created: 2024-2-27T11:13
e ISSN: 1618-7601
has issn l: 1618-7598
issue: 8
has NLM journal title abbreviation: Eur J Health Econ
publication name: The European journal of health economics : HEPAC : health economics in prevention and care
language: eng
has national library of medicine journal id: 101134867
derived from: NLM
starting page: 1417
ending page: 1435
has place of publication: Germany
has primary subject term: D003362Q000379
has primary subject term: D005901Q000191
has primary subject term: D019057
has subject term: D006801
has subject term: D006304
source: Eur J Health Econ. 2024-11;25(8):1417-1435.
volume: 25

Optimization of an in vitro Pseudomonas aeruginosa Biofilm Model to Examine Antibiotic Pharmacodynamics at the Air-Liquid Interface.
pmid: 38429317
abstract: Pseudomonas aeruginosa is an important cause of lower respiratory tract infections, such as ventilator-associated bacterial pneumonia (VABP). Using inhaled antibiotics to treat VABP can achieve high drug concentrations at the infection site while minimizing systemic toxicities. Despite the theoretical advantages, clinical trials have failed to show a benefit for inhaled antibiotic therapy in treating VABP. A potential reason for this discordance is the presence of biofilm-embedded bacteria in lower respiratory tract infections. Drug selection and dosing are often based on data from bacteria grown planktonically. In the present study, an in vitro air-liquid interface pharmacokinetic/pharmacodynamic biofilm model was optimized to evaluate the activity of simulated epithelial lining fluid exposures of inhaled and intravenous doses of polymyxin B and tobramycin against two P. aeruginosa strains. Antibiotic activity was also determined against the P. aeruginosa strains grown planktonically. Our study revealed that inhaled antibiotic exposures were more active than their intravenous counterparts across biofilm and planktonic populations. Inhaled exposures of polymyxin B and tobramycin exhibited comparable activity against planktonic P. aeruginosa. Although inhaled polymyxin B exposures were initially more active against P. aeruginosa biofilms (through 6 h), tobramycin was more active by the end of the experiment (48 h). Together, these data slightly favor the use of inhaled tobramycin for VABP caused by biofilm-forming P. aeruginosa that are not resistant to either antibiotic. The optimized in vitro air-liquid interface pharmacokinetic/pharmacodynamic biofilm model may be beneficial for the development of novel anti-biofilm agents or to optimize antibiotic dosing for infections such as VABP.
rights: © 2024. The Author(s).
has PII: 10.1038/s41522-024-00483-y
doi: 10.1038/s41522-024-00483-y
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Tan X
      type: Person
      first name: Xing
      last name: Tan
      member of: Department of Pharmacy Practice, University of Illinois Chicago College of Pharmacy, Chicago, IL, USA.
  slot:
    index: 2
    item: Huang Y
      type: Person
      first name: Yanqin
      last name: Huang
      member of: Department of Pharmacy Practice, University of Illinois Chicago College of Pharmacy, Chicago, IL, USA.
  slot:
    index: 3
    item: Rana A
      type: Person
      first name: Amisha
      last name: Rana
      member of: Department of Pharmacy Practice, University of Illinois Chicago College of Pharmacy, Chicago, IL, USA.
  slot:
    index: 4
    item: Singh N
      type: Person
      first name: Nidhi
      last name: Singh
      member of: Department of Pharmacy Practice, University of Illinois Chicago College of Pharmacy, Chicago, IL, USA.
  slot:
    index: 5
    item: Abbey TC
      type: Person
      first name: Taylor C
      last name: Abbey
      member of: Department of Pharmacy Practice, University of Illinois Chicago College of Pharmacy, Chicago, IL, USA.
  slot:
    index: 6
    item: Chen H
      type: Person
      first name: Hui
      last name: Chen
      member of: Mass Spectrometry Core, Research Resources Center, University of Illinois Chicago, Chicago, IL, USA.
  slot:
    index: 7
    item: Toth PT
      type: Person
      first name: Peter T
      last name: Toth
      member of: Fluorescence Imaging Core, Research Resources Center, University of Illinois Chicago, Chicago, IL, USA.
  slot:
    index: 8
    item: Bulman ZP
      type: Person
      first name: Zackery P
      last name: Bulman
      member of: Department of Pharmacy Practice, University of Illinois Chicago College of Pharmacy, Chicago, IL, USA. bulman@uic.edu.
created: 2024-3-2T10:43
date last updated: 2025-01-20
issued: 2024-03-01
dp: 2024 Mar 01
created: 2024-3-1T23:18
e ISSN: 2055-5008
has issn l: 2055-5008
issue: 1
has NLM journal title abbreviation: NPJ Biofilms Microbiomes
publication name: NPJ biofilms and microbiomes
language: eng
has national library of medicine journal id: 101666944
derived from: NLM
pg: 16
has place of publication: United States
has primary subject term: D011552Q000188
has primary subject term: D012141
has subject term: D006801
has subject term: D000900
has subject term: D011550
has subject term: D011112Q000494
has subject term: D014031Q000494
has subject term: D018441
source: NPJ Biofilms Microbiomes. 2024-03-01;10(1):16.
volume: 10

Outcomes of Eyes Lost to Follow-up After Treatment With Intraocular or Periocular Steroid Injections.
pmid: 38465363
abstract: Purpose: To evaluate the visual, intraocular pressure (IOP), and anatomic outcomes of eyes with loss to follow-up (LTFU) after intravitreal or periocular steroid injections. Methods: Patients receiving intraocular or periocular steroid injections and with LTFU for at least 180 days were included in this retrospective cohort study. Charts were reviewed for the visual acuity (VA), IOP, and central foveal thickness at the visit before LTFU, the first return visit, and 3, 6, and 12 months after return. Results: Fifty-three eyes of 47 patients were identified. The mean (±SD) age was 62.3 ± 14.9 years, the mean LTFU time was 295 ± 181.2 days (range, 182-1101), and the mean follow-up after return was 354 ± 339.3 days (range, 32-1141). The overall mean number of steroid injections was 5.2 ± 3.9 (range, 1-18). Compared with the mean logMAR VA at the visit before LTFU (0.59 [Snellen 20/77]), the mean VA remained stable at all timepoints after return as follows: return visit (0.62 [20/83]; P = .6), month 3 (0.55 [20/70]; P = .6), month 6 (0.55 [20/70]; P = .5), month 12 (0.64 [20/87]; P = .6), and final visit (0.69 [20/97]; P = .2). At the first return visit, 8 (15%) of 53 patients had an IOP of 21 mm Hg or higher (range, 21-31); 2 required treatment with a new antihypertensive medication (latanoprost and timolol, respectively). Conclusions: Patients with LTFU after receiving steroid injections maintained their VA. No patient required incisional glaucoma surgery. Compared with other etiologies, eyes with diabetic macular edema had a greater increase in IOP.
rights: © The Author(s) 2024.
has PII: 10.1177_24741264231218044
doi: 10.1177/24741264231218044
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Mahmoudzadeh R
      type: Person
      first name: Raziyeh
      last name: Mahmoudzadeh
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 2
    item: Salabati M
      type: Person
      first name: Mirataollah
      last name: Salabati
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 3
    item: Israilevich R
      type: Person
      first name: Rachel
      last name: Israilevich
      member of: Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 4
    item: Hinkle JW
      type: Person
      first name: John W
      last name: Hinkle
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 5
    item: Obeid A
      type: Person
      first name: Anthony
      last name: Obeid
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 6
    item: Khan MA
      type: Person
      first name: M Ali
      last name: Khan
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 7
    item: Hsu J
      type: Person
      first name: Jason
      last name: Hsu
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
  slot:
    index: 8
    item: Chaudhary V
      type: Person
      first name: Varun
      last name: Chaudhary
      member of: Hamilton Regional Eye Institute, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.Department of Surgery, McMaster University, Hamilton, ON, Canada.
  slot:
    index: 9
    item: Garg SJ
      type: Person
      first name: Sunir J
      last name: Garg
      member of: Mid Atlantic Retina, Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
created: 2024-3-11T06:43
date last updated: 2025-01-20
created: 2024-3-11T04:50
e ISSN: 2474-1272
has issn l: 2474-1264
issue: 2
has NLM journal title abbreviation: J Vitreoretin Dis
publication name: Journal of vitreoretinal diseases
language: eng
has national library of medicine journal id: 101700301
derived from: NLM
starting page: 144
ending page: 151
has place of publication: United States
source: J Vitreoretin Dis. ;8(2):144-151.
volume: 8

Diurnal Pain Classification in Critically Ill Patients using Machine Learning on Accelerometry and Analgesic Data.
pmid: 38463539
abstract: Quantifying pain in patients admitted to intensive care units (ICUs) is challenging due to the increased prevalence of communication barriers in this patient population. Previous research has posited a positive correlation between pain and physical activity in critically ill patients. In this study, we advance this hypothesis by building machine learning classifiers to examine the ability of accelerometer data collected from daily wearables to predict self-reported pain levels experienced by patients in the ICU. We trained multiple Machine Learning (ML) models, including Logistic Regression, CatBoost, and XG-Boost, on statistical features extracted from the accelerometer data combined with previous pain measurements and patient demographics. Following previous studies that showed a change in pain sensitivity in ICU patients at night, we performed the task of pain classification separately for daytime and nighttime pain reports. In the pain versus no-pain classification setting, logistic regression gave the best classifier in daytime (AUC: 0.72, F1-score: 0.72), and CatBoost gave the best classifier at nighttime (AUC: 0.82, F1-score: 0.82). Performance of logistic regression dropped to 0.61 AUC, 0.62 F1-score (mild vs. moderate pain, nighttime), and CatBoost's performance was similarly affected with 0.61 AUC, 0.60 F1-score (moderate vs. severe pain, daytime). The inclusion of analgesic information benefited the classification between moderate and severe pain. SHAP analysis was conducted to find the most significant features in each setting. It assigned the highest importance to accelerometer-related features on all evaluated settings but also showed the contribution of the other features such as age and medications in specific contexts. In conclusion, accelerometer data combined with patient demographics and previous pain measurements can be used to screen painful from painless episodes in the ICU and can be combined with analgesic information to provide moderate cla[cell cut: 2061 characters, first 2000 kept]
doi: 10.1109/bibm58861.2023.10385764
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Sena J
      type: Person
      first name: Jessica
      last name: Sena
      member of: Federal University of Minas Gerais/Department of Computer Science, Belo Horizonte, Brazil.
  slot:
    index: 2
    item: Bandyopadhyay S
      type: Person
      first name: Sabyasachi
      last name: Bandyopadhyay
      member of: University of Florida/J. Crayton Pruitt Family Department of Biomedical Engineering, Gainesville, USA.University of Florida/Intelligent Critical Care Center, Gainesville, Florida, USA.
  slot:
    index: 3
    item: Mostafiz MT
      type: Person
      first name: Mohammad Tahsin
      last name: Mostafiz
      member of: University of Florida/J. Crayton Pruitt Family Department of Biomedical Engineering, Gainesville, USA.
  slot:
    index: 4
    item: Davidson A
      type: Person
      first name: Andrea
      last name: Davidson
      member of: University of Florida/Intelligent Critical Care Center, Gainesville, Florida, USA.University of Florida/Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, College of Medicine, Gainesville, Florida, USA.
  slot:
    index: 5
    item: Guan Z
      type: Person
      first name: Ziyuan
      last name: Guan
      member of: University of Florida/Intelligent Critical Care Center, Gainesville, Florida, USA.University of Florida/Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, College of Medicine, Gainesville, Florida, USA.
  slot:
    index: 6
    item: Barreto J
      type: Person
      first name: Jesimon
      last name: Barreto
      member of: Federal University of Minas Gerais/Department of Computer Science, Belo Horizonte, Brazil.
  slot:
    index: 7
    item: Ozrazgat-Baslanti T
      type: Person
      first name: Tezcan
      last name: Ozrazgat-Baslanti
      member of: University of Florida/Intelligent Critical Care Center, Gainesville, Florida, USA.University of Florida/Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, College of Medicine, Gainesville, Florida, USA.
  slot:
    index: 8
    item: Tighe P
      type: Person
      first name: Patrick
      last name: Tighe
      member of: University of Florida/Department of Anesthesiology, College of Medicine, Gainesville, Florida.
  slot:
    index: 9
    item: Bihorac A
      type: Person
      first name: Azra
      last name: Bihorac
      member of: University of Florida/Intelligent Critical Care Center, Gainesville, Florida, USA.University of Florida/Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, College of Medicine, Gainesville, Florida, USA.
  slot:
    index: 10
    item: Schwartz WR
      type: Person
      first name: William Robson
      last name: Schwartz
      member of: Federal University of Minas Gerais/Department of Computer Science, Belo Horizonte, Brazil.
  slot:
    index: 11
    item: Rashidi P
      type: Person
      first name: Parisa
      last name: Rashidi
      member of: University of Florida/J. Crayton Pruitt Family Department of Biomedical Engineering, Gainesville, USA.University of Florida/Intelligent Critical Care Center, Gainesville, Florida, USA.
created: 2024-3-11T06:44
date last updated: 2025-01-20
issued: 2023-12
dp: 2023 Dec
created: 2024-3-11T04:22
has NLM journal title abbreviation: IEEE Int Conf Bioinform Biomed Workshops
publication name: IEEE International Conference on Bioinformatics and Biomedicine workshops. IEEE International Conference on Bioinformatics and Biomedicine
language: eng
has national library of medicine journal id: 101647436
derived from: NLM
starting page: 2207
ending page: 2212
has place of publication: United States
source: IEEE Int Conf Bioinform Biomed Workshops. 2023-12;2023():2207-2212.
volume: 2023

Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation.
pmid: 38458275
abstract: Diabetic wound healing is a substantial clinical challenge, characterized by delayed angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from shiitake mushrooms, has the potential to regulate both macrophage polarization and angiogenesis, though this aspect remains inadequately explored. To facilitate lentinan's clinical utility, we have developed a GelMA hydrogel encapsulated with lentinan (10 μM), offering a controlled release mechanism for sustained lentinan delivery at the wound site. Application of the lentinan-encapsulated delivery system topically significantly expedites wound closure compared to control groups. Furthermore, histological examination demonstrates enhanced neovascularization and reduced inflammation in lentinan-treated wounds, as evidenced by increased M2 macrophage infiltration. Moreover, our results indicated that lentinan-induced AMPK activation promotes DAF16 expression, enhancing the resistance of macrophages and HUVECs to oxidative stress in high-glucose environments, thereby promoting M2 macrophage polarization and angiogenesis. All these findings underscore lentinan's capacity to modulate macrophage polarization and angiogenesis via the AMPK/DAF16 pathway, ultimately facilitating the healing of diabetic wounds.
rights: Copyright © 2024 Elsevier B.V. All rights reserved.
has PII: S0141-8130(24)01520-4
doi: 10.1016/j.ijbiomac.2024.130716
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Jia Z
      type: Person
      first name: Zhiwei
      last name: Jia
      member of: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 101100, China. Electronic address: jiazhiweivip@163.com.
  slot:
    index: 2
    item: Chen L
      type: Person
      first name: Lei
      last name: Chen
      member of: Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
  slot:
    index: 3
    item: Gu D
      type: Person
      first name: Dongqiang
      last name: Gu
      member of: Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
  slot:
    index: 4
    item: Li X
      type: Person
      first name: Xingxuan
      last name: Li
      member of: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 101100, China.
  slot:
    index: 5
    item: Wen T
      type: Person
      first name: Tianlin
      last name: Wen
      member of: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 101100, China.
  slot:
    index: 6
    item: Li W
      type: Person
      first name: Wei
      last name: Li
      member of: Department of Sports Medicine, Fourth Medical Center of PLA General Hospital, Beijing 100048, China. Electronic address: weilichn@126.com.
created: 2024-3-9T10:42
date last updated: 2025-01-19
issued: 2024-04
dp: 2024 Apr
created: 2024-3-8T19:12
e ISSN: 1879-0003
has issn l: 0141-8130
issue: Pt 2
has NLM journal title abbreviation: Int J Biol Macromol
publication name: International journal of biological macromolecules
language: eng
has national library of medicine journal id: 7909578
derived from: NLM
pg: 130716
has place of publication: Netherlands
has primary subject term: D020100
has primary subject term: D003920
has subject term: D006801
has subject term: D007912Q000494
has subject term: D055372
has subject term: http://id.nlm.nih.gov/mesh/D000096482
has subject term: D014945
has subject term: D007249Q000473
source: Int J Biol Macromol. 2024-04;264(Pt 2):130716.
volume: 264

Management of Neuropathic Pain with Neurectomy Combined with Dermal Sensory Regenerative Peripheral Nerve Interface (DS-RPNI).
pmid: 38495065
abstract: Neuropathic pain affects a large percentage of the U.S. population and leads to tremendous morbidity. Numerous nonsurgical and surgical treatments have been utilized to try and manage neuropathic pain with varying degrees of success. Recent research investigating ways to improve prosthetic control have identified new mechanisms for preventing neuromas in both motor and sensory nerves with free muscle and dermal grafts, respectively. These procedures have been used to treat chronic neuropathic pain in nonamputees, as well, in order to reduce failure rates found with traditional neurectomy procedures. Herein, we focus our attention on Dermal Sensory-Regenerative Peripheral Nerve Interfaces (DS-RPNI, free dermal grafts) which can be used to physiologically cap sensory nerves following neurectomy and have been shown to significantly decrease neuropathic pain.
rights: Thieme. All rights reserved.
has PII: sps01409
doi: 10.1055/s-0043-1778041
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Hespe GE
      type: Person
      first name: Geoffrey E
      last name: Hespe
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 2
    item: Brown DL
      type: Person
      first name: David L
      last name: Brown
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
created: 2024-3-18T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:14
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 48
ending page: 52
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):48-52.
volume: 38

Regenerative Peripheral Nerve Interface Surgery for the Management of Chronic Posttraumatic Neuropathic Pain.
pmid: 38495062
abstract: Chronic pain resulting from peripheral nerve injury remains a common issue in the United States and affects 7 to 10% of the population. Regenerative Peripheral Nerve Interface (RPNI) surgery is an innovative surgical procedure designed to treat posttraumatic neuropathic pain, particularly when a symptomatic neuroma is present on clinical exam. RPNI surgery involves implantation of a transected peripheral nerve into an autologous free muscle graft to provide denervated targets to regenerating axons. RPNI surgery has been found in animal and human studies to be highly effective in addressing postamputation pain. While most studies have reported its uses in the amputation patient population for the treatment of neuroma and phantom limb pain, RPNI surgery has recently been used to address refractory headache, postmastectomy pain, and painful donor sites from the harvest of neurotized flaps. This review summarizes the current understanding of RPNI surgery for the treatment of chronic neuropathic pain.
rights: Thieme. All rights reserved.
has PII: sps01405
doi: 10.1055/s-0043-1778078
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Lee JC
      type: Person
      first name: Jennifer C
      last name: Lee
      member of: Section of Plastic Surgery, Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.
  slot:
    index: 2
    item: Kemp SWP
      type: Person
      first name: Stephen W P
      last name: Kemp
      member of: Section of Plastic Surgery, Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.
  slot:
    index: 3
    item: Kung TA
      type: Person
      first name: Theodore A
      last name: Kung
      member of: Section of Plastic Surgery, Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.
created: 2024-3-18T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:14
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 19
ending page: 24
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):19-24.
volume: 38

A Qualitative Systematic Review of Healthcare Practitioners' Experience of Workplace Violence.
pmid: 38456107
abstract: Healthcare practitioners face significant risks of workplace violence due to various reasons such as hospital congestion, miscommunication, and aggressive behaviours of patients and relatives. Exposure to workplace violence may disrupt the workflow process and compromise patient care in healthcare facilities, ultimately affecting job performance, reducing job satisfaction, and negatively affecting the physical and mental health of healthcare practitioners. This study aimed to review all the published studies conducted on the experiences of workplace violence among healthcare practitioners. This study is a systematic review of qualitative studies. Data were collected through online databases including ScienceDirect, PubMed, MEDLINE and JSTOR were searched from the year 2015-2021. The inclusion criteria were: qualitative methods and mixed methods of data collection and analysis; studies that were carried out among healthcare practitioners who have been experience on workplace violence; scope of the primary studies included experience of workplace violence; and published in English/Malay in academic journal between 2015 and 2021. A total of 15 papers were included in the final analysis. The overall quality of the included papers was high. Of the 15 papers, 12 studies fully met the CASP criteria. The results of the 15 included studies were organised into the thematic groups of: i) verbal violence as the common workplace violence; ii) perceived causes of workplace violence and iii) seeking help. Across different countries, verbal violence was the most common type of workplace violence reported by healthcare practitioners. This review also identified that a lack of information, failure to meet patient expectations, and delayed treatment were the main contributing factors to workplace violence.
rights: © Penerbit Universiti Sains Malaysia, 2024.
has PII: 04mjms3101_ra
doi: 10.21315/mjms2024.31.1.4
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Emary EAM
      type: Person
      first name: Ezatul Alia Md
      last name: Emary
      member of: Emergency Department, Hospital Sultan Idris Shah Serdang, Selangor, Malaysia.
  slot:
    index: 2
    item: Arifin SRM
      type: Person
      first name: Siti Roshaidai Mohd
      last name: Arifin
      member of: Department of Special Care Nursing, Kulliyah of Nursing, International Islamic University Malaysia, Pahang, Malaysia.
  slot:
    index: 3
    item: Yusof MZ
      type: Person
      first name: Muhammad Zubir
      last name: Yusof
      member of: Department of Community Medicine, Kulliyah of Medicine, International Islamic University Malaysia, Pahang, Malaysia.
created: 2024-3-8T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-8T04:09
ISSN: 1394-195X
has issn l: 1394-195X
issue: 1
has NLM journal title abbreviation: Malays J Med Sci
publication name: The Malaysian journal of medical sciences : MJMS
language: eng
has national library of medicine journal id: 101126308
derived from: NLM
starting page: 51
ending page: 61
has place of publication: Malaysia
source: Malays J Med Sci. 2024-02;31(1):51-61.
volume: 31

Financial Toxicity in Breast Reconstruction: The Role of the Surgeon-Patient Cost-of-Care Discussion.
pmid: 38495060
abstract: The financial burden of breast cancer treatment and reconstruction is a significant concern for patients. Patient desire for preoperative cost-of-care counseling while navigating the reconstructive process remains unknown. A cross-sectional survey of women from the Love Research Army was conducted. An electronic survey was distributed to women over 18 years of age and at least 1 year after postmastectomy breast reconstruction. Descriptive statistics and multivariable modeling were used to determine desire for and occurrence of cost-of-care discussions, and factors associated with preference for such discussions. Secondary outcomes included the association of financial toxicity with desire for cost discussions. Among 839 women who responded, 620 women (74.1%) did not speak to their plastic surgeon and 480 (57.4%) did not speak to a staff member regarding costs of breast reconstruction. Of the 550 women who reported it would have been helpful to discuss costs, 315 (57.3%) were not engaged in a financial conversation initiated by a health care provider. A greater proportion of women who reported financial toxicity, compared to those who did not, would have preferred to discuss costs with their plastic surgeon (65.2% vs. 43.5%, p < 0.001) or a staff member (75.5% vs. 59.3%, p < 0.001). Among women with financial toxicity, those who had some form of insurance (private, Medicaid, Medicare, other ) were significantly more likely to prefer a cost-of-care discussion ( p < 0.001, p = 0.02, p = 0.05, p = 0.01). Financial discussions about the potential costs of breast reconstruction seldom occurred in this national cohort. Given the reported preference and unmet need for financial discussions by a majority of women, better cost transparency and communication is needed.
rights: Thieme. All rights reserved.
has PII: sps01408
doi: 10.1055/s-0043-1778040
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Baglien BD
      type: Person
      first name: Brigit D
      last name: Baglien
      member of: Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 2
    item: Ganesh Kumar N
      type: Person
      first name: Nishant
      last name: Ganesh Kumar
      member of: Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 3
    item: Berlin NL
      type: Person
      first name: Nicholas L
      last name: Berlin
      member of: Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 4
    item: Hawley ST
      type: Person
      first name: Sarah T
      last name: Hawley
      member of: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.Department of Health Behavior and Health Education, University of Michigan, Ann Arbor, Michigan.Ann Arbor VA Center for Clinical Management Research, Ann Arbor, Michigan.
  slot:
    index: 5
    item: Jagsi R
      type: Person
      first name: Reshma
      last name: Jagsi
      member of: Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia.
  slot:
    index: 6
    item: Momoh AO
      type: Person
      first name: Adeyiza O
      last name: Momoh
      member of: Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
created: 2024-3-18T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:14
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 39
ending page: 47
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):39-47.
volume: 38

Outcomes of Chandelier-Assisted Scleral Buckling in Rhegmatogenous Retinal Detachments: Systematic Review and Meta-analysis.
pmid: 38465358
abstract: Purpose: To examine the outcomes of chandelier endoillumination-assisted scleral buckling (chandelier scleral buckling) for rhegmatogenous retinal detachments (RRDs) and compare them with those of standard scleral buckling using indirect ophthalmoscopy. Methods: A literature search was performed on April 15, 2023. Outcomes analyzed included the primary anatomic success rates, surgical duration, and complication rates. A meta-analysis of proportions estimated the pooled success rate of chandelier scleral buckling. In addition, meta-analyses compared the success rates between pseudophakic eyes and phakic eyes having chandelier scleral buckling and compared success rates and surgical duration between standard scleral buckling and chandelier scleral buckling. Results: Thirty studies with 1133 eyes were included. The pooled primary anatomic success rate of chandelier scleral buckling was 91.7% (95% CI, 89.6%-93.6%). In studies comparing success rates between the 2 techniques, there was no significant difference (risk ratio, 1.01; 95% CI, 0.94-1.08; P = .80). The surgical times were significantly shorter with chandelier scleral buckling than with standard scleral buckling (mean difference, -18.83; 95% CI, -30.88 to -6.79; P = .002). There was no significant difference in the success rate between pseudophakic eyes and phakic eyes (risk ratio, 0.99; 95% CI, 0.91-1.08; P = .89). No cases of endophthalmitis were reported. Conclusions: Chandelier endoillumination-assisted scleral buckling may be a promising technique given its high rate of primary anatomic success for RRDs and success rates similar to those of standard scleral buckling. There was no significant difference in the efficacy of chandelier scleral buckling between pseudophakic eyes and phakic eyes.
rights: © The Author(s) 2024.
has PII: 10.1177_24741264231224956
doi: 10.1177/24741264231224956
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Zhu D
      type: Person
      first name: Daniel
      last name: Zhu
      member of: Department of Ophthalmology, Northwell Health Eye Institute, Great Neck, NY, USA.
  slot:
    index: 2
    item: Wong A
      type: Person
      first name: Amanda
      last name: Wong
      member of: Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
  slot:
    index: 3
    item: Jiao G
      type: Person
      first name: George
      last name: Jiao
      member of: Department of Ophthalmology, Northwell Health Eye Institute, Great Neck, NY, USA.
  slot:
    index: 4
    item: Zhang C
      type: Person
      first name: Charles
      last name: Zhang
      member of: Department of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, State University of New York, University at Buffalo, Buffalo, NY USA.
  slot:
    index: 5
    item: Yakobashvili D
      type: Person
      first name: Daniela
      last name: Yakobashvili
      member of: Institute of Ophthalmology & Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA.
  slot:
    index: 6
    item: Zhu E
      type: Person
      first name: Edward
      last name: Zhu
      member of: Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  slot:
    index: 7
    item: Tham T
      type: Person
      first name: Tristan
      last name: Tham
      member of: Department of Otolaryngology-Head and Neck Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
  slot:
    index: 8
    item: Lieberman R
      type: Person
      first name: Ronni
      last name: Lieberman
      member of: Department of Ophthalmology, Icahn School of Medicine, Mount Sinai Medical Center, and New York City Health and Hospitals, New York, NY, USA.
created: 2024-3-11T06:42
date last updated: 2025-01-20
created: 2024-3-11T04:50
e ISSN: 2474-1272
has issn l: 2474-1264
issue: 2
has NLM journal title abbreviation: J Vitreoretin Dis
publication name: Journal of vitreoretinal diseases
language: eng
has national library of medicine journal id: 101700301
derived from: NLM
starting page: 158
ending page: 167
has place of publication: United States
source: J Vitreoretin Dis. ;8(2):158-167.
volume: 8

A Historical Review of Racial, Ethnic, and Gender Diversity in Plastic Surgery at the University of Michigan.
pmid: 38495058
abstract: In this article, we examine the 60-year history of diversity efforts within the Section of Plastic Surgery at the University of Michigan (UofM) in the context of national trends. We describe the experiences of pioneering Underrepresented in Medicine (URiM) and female graduates of the program. James Norris, MD, and Christine Sullivan, MD, were the first URiM and female graduates from UofM in 1974 and 1989, respectively. Currently, women constitute over one-half the plastic surgery trainees at UofM, but URiM trainee representation remains limited. Dr. Adeyiza Momoh and Dr. Amy Alderman were the first URiM and female faculty members hired in 2011 and 2004, respectively. At present, there are four URiM and seven female faculty members in the Section. With a shared vision, supportive leadership, and motivation to change, faculty diversity has increased substantially. Additional strategies, including ongoing pipeline programs in medicine and science for URiM and women, are needed to further increase workforce diversity in plastic surgery.
rights: Thieme. All rights reserved.
has PII: sps01412
doi: 10.1055/s-0043-1778044
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Levy JJS
      type: Person
      first name: Julien J S
      last name: Levy
      member of: Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
  slot:
    index: 2
    item: Hooper RC
      type: Person
      first name: Rachel C
      last name: Hooper
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
created: 2024-3-18T06:42
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:14
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 69
ending page: 73
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):69-73.
volume: 38

A History of Gender-Affirming Surgery at the University of Michigan: Lessons for Today.
pmid: 38495068
abstract: The University of Michigan has played an important role in advancing gender-affirming surgery programs in the United States. The University of Michigan was home to a little-known gender identity clinic shortly after the opening of the first such clinic at Johns Hopkins. Since 1995, the University of Michigan Comprehensive Services Program (UMCGSP) has been continually offering surgical services to transgender and gender diverse patients. Here, we present the history of both programs, drawn from program documents and oral history, and explore their implications for the future sustainability of gender-affirming surgery programs. The original gender identity clinic opened in 1968, and operated in a multidisciplinary fashion, similar to other clinics at the time. Eventually, the clinic was closed due to disinvestment and lack of sufficient providers to maintain the program, problems which are being increasingly recognized as barriers for similar programs. The modern program, UMCGSP is perhaps the longest continually running gender-affirming surgical program at an academic center. In spite of challenges, key investments in education, statewide community engagement, and the development of a comprehensive care model have helped UMCGSP avoid the pitfalls of the earlier clinic and remain relevant throughout its nearly 30-year history. In the face of rising challenges to gender-affirming care in the United States, much can be learned from the sustainability of the UMCGSP. Institutions seeking to maintain gender-affirming surgery programs should ensure the availability of comprehensive care and promote the education of the health care workforce.
rights: Thieme. All rights reserved.
has PII: sps01410
doi: 10.1055/s-0043-1778042
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Roblee C
      type: Person
      first name: Cole
      last name: Roblee
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
  slot:
    index: 2
    item: Keyes O
      type: Person
      first name: Os
      last name: Keyes
      member of: Department of Human Centered Design and Engineering, University of Washington, Seattle, Washington.
  slot:
    index: 3
    item: Blasdel G
      type: Person
      first name: Gaines
      last name: Blasdel
      member of: University of Michigan Medical School, Medical School, Ann Arbor, Michigan.
  slot:
    index: 4
    item: Haley C
      type: Person
      first name: Caleb
      last name: Haley
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 5
    item: Lane M
      type: Person
      first name: Megan
      last name: Lane
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 6
    item: Marquette L
      type: Person
      first name: Lauren
      last name: Marquette
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 7
    item: Hsu J
      type: Person
      first name: Jessica
      last name: Hsu
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 8
    item: Kuzon WM
      type: Person
      first name: William M
      last name: Kuzon
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
created: 2024-3-18T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:14
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 53
ending page: 60
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):53-60.
volume: 38

Glycemic Control in Patients Living With HIV Initiated on Integrase Inhibitor-Based Three-Drug Antiretroviral Therapy.
pmid: 38525088
abstract: Background: The increased risk of cardio-metabolic disorders associated with people living with human immunodeficiency virus (HIV) is of growing importance. Given the broad adoption of integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as first-line therapy for HIV, additional data are needed regarding the metabolic effects of these regimens. Objective: The purpose of this study is to assess glycemic control in patients started on INSTI-based 3-drug regimens over a 2-year period. Methods: A retrospective study was conducted on patients seen in the Brooklyn Hospital Center. Men and nonpregnant, nonlactating women aged 18 years or older with a diagnosis of HIV who were initiated on or switched to an ART consisting of 2 nucleoside reverse transcriptase inhibitors (NRTIs) plus an INSTI were included in the analysis. The primary endpoint is change in A1C from baseline (pre-INSTI initiation) to 2 years after initiation. Results: Two hundred fifty-one patients were eligible based on specified inclusion and exclusion criteria. Overall, a statistically significant increase in A1C was seen in all patients started on INSTI-based regimen (95% CI, 0.10-0.36; P < 0.001). Primarily patients on both elvitegravir-based and bictegravir-based regimens saw the most significant increase in A1C: 0.16% (95% CI, 0.04-0.27; P = 0.006) and 0.39% (95% CI, 0.02-0.76; P = 0.038), respectively. Conclusion and Relevance: Integrase strand-transfer inhibitor-based 3-drug ART was associated with a small but statistically significant increase in A1C over a 2-year period, requiring additional monitoring by clinicians.
rights: © The Author(s) 2024.
has PII: 10.1177_87551225231221059
doi: 10.1177/87551225231221059
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Gerber A
      type: Person
      first name: Anthony
      last name: Gerber
      member of: New York City Health + Hospital/Bellevue, New York, NY, USA.The Brooklyn Hospital Center, Brooklyn, NY, USA.
  slot:
    index: 2
    item: Fischetti B
      type: Person
      first name: Briann
      last name: Fischetti
      member of: The Brooklyn Hospital Center, Brooklyn, NY, USA.Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, USA.
  slot:
    index: 3
    item: Popova O
      type: Person
      first name: Olga
      last name: Popova
      member of: Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, USA.Texas Children's Hospital, Houston, TX, USA.
  slot:
    index: 4
    item: Longo M
      type: Person
      first name: Maria
      last name: Longo
      member of: The Brooklyn Hospital Center, Brooklyn, NY, USA.Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, USA.
created: 2024-3-25T06:43
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 Apr
created: 2024-3-25T04:36
ISSN: 8755-1225
has issn l: 1549-4810
issue: 2
has NLM journal title abbreviation: J Pharm Technol
publication name: The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
language: eng
has national library of medicine journal id: 8504643
derived from: NLM
starting page: 85
ending page: 91
has place of publication: United States
source: J Pharm Technol. 2024-04;40(2):85-91.
volume: 40

Mean Ocular Perfusion Pressure Effect During Pars Plana Vitrectomy on the Foveal Avascular Zone: A Pilot Study.
pmid: 38465364
abstract: Purpose: To evaluate the effect of mean ocular perfusion pressure on the foveal avascular zone (FAZ) area in eyes with successful retinal detachment (RD) surgery. Methods: This prospective pilot fellow eye-controlled study measured the intraoperative mean ocular perfusion pressure in eyes having surgery for rhegmatogenous RD (RRD). Postoperatively, the FAZ area was measured; the change was calculated as the difference in the FAZ area between the operated eye and the contralateral control eye. Results: The study comprised 8 patients with a mean age (±SD) of 53.38 ± 13.92 years. The mean superficial FAZ area was not different between operated eyes and control eyes, while the deep FAZ area was significantly larger in operated eyes. There was a strong negative correlation between the mean ocular perfusion pressure and the change in the deep FAZ area (Spearman ρ, -0.73; P = .04); the correlation between the mean ocular perfusion pressure and the change in the superficial FAZ area was not significant (Spearman ρ, -0.24; P = .57). A significant linear regression was found between the mean ocular perfusion pressure and the change in the deep FAZ area (R2 = 0.388). The predicted enlargement of the deep FAZ area was 0.03 mm with every 1 mm Hg decrease in the mean ocular perfusion pressure. Conclusions: Lower intraoperative mean ocular perfusion pressure is associated with enlargement of the deep FAZ area in eyes having successful RRD surgery.
rights: © The Author(s) 2024.
has PII: 10.1177_24741264231223389
doi: 10.1177/24741264231223389
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Shaheen F
      type: Person
      first name: Fiza
      last name: Shaheen
      member of: Ophthalmology Department, Shifa International Hospital, Islamabad, Pakistan.Ophthalmology Department, Alshifa Trust Eye Hospital, Islamabad, Pakistan.
  slot:
    index: 2
    item: Khan HA
      type: Person
      first name: Hashim Ali
      last name: Khan
      member of: Faculty of Medicine & Health, University of New South Wales, Sydney, NSW, Australia.
  slot:
    index: 3
    item: Afzal F
      type: Person
      first name: Farooq
      last name: Afzal
      member of: Ophthalmology Department, Shifa International Hospital, Islamabad, Pakistan.
  slot:
    index: 4
    item: Awan MA
      type: Person
      first name: Muhammad Amer
      last name: Awan
      member of: Ophthalmology Department, Shifa International Hospital, Islamabad, Pakistan.
created: 2024-3-11T06:44
date last updated: 2025-01-20
created: 2024-3-11T04:50
e ISSN: 2474-1272
has issn l: 2474-1264
issue: 2
has NLM journal title abbreviation: J Vitreoretin Dis
publication name: Journal of vitreoretinal diseases
language: eng
has national library of medicine journal id: 101700301
derived from: NLM
starting page: 152
ending page: 157
has place of publication: United States
source: J Vitreoretin Dis. ;8(2):152-157.
volume: 8

Pyrocarbon Lunate Arthroplasty: An Option for the Young Patient with Advanced Kienbock Disease.
pmid: 38495070
abstract: Kienbock disease, or avascular necrosis of the lunate, is an uncommon cause of a painful and stiff wrist. Management options range from conservative treatment in the form of immobilization and corticosteroid injections to a wide variety of surgical treatments that depend on the structural integrity of the lunate, intercarpal relationships, and the condition of the articular cartilage of the wrist. A particularly difficult problem lies in the management of young patient in whom vascularized bone grafting of the lunate has failed but in whom arthritis has not yet developed. Pyrocarbon lunate implant arthroplasty is a newer treatment option for such a patient, and allows the preservation of the remainder of the proximal carpal row while directly addressing the degenerative lunate. This article describes the evidence and surgical technique for lunate implant arthroplasty and presents an illustrative case example.
rights: Thieme. All rights reserved.
has PII: sps01406
doi: 10.1055/s-0043-1778036
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Dwivedi SS
      type: Person
      first name: Shashank S
      last name: Dwivedi
      member of: Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
  slot:
    index: 2
    item: Chung KC
      type: Person
      first name: Kevin C
      last name: Chung
      member of: Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
created: 2024-3-18T06:43
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:15
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 25
ending page: 30
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):25-30.
volume: 38

H Vessel Formation as a Marker for Enhanced Bone Healing in Irradiated Distraction Osteogenesis.
pmid: 38495069
abstract: In the setting of bone defects, the injured vasculature and loss of hemodynamic inflow leads to hematoma formation and low oxygen tension which stimulates vascular expansion through the HIf-1α pathway. Most importantly, this pathway upregulates sprouting of type H vessels (CD31hiEmcnhi vessels). H vessels engage in direct interaction with perivascular osteoprogenitor cells (OPCs), osteoblasts, and preosteoclasts of bone formation and remodeling. This angiogenic-osteogenic coupling leads to synchronous propagation of vascular and bony tissue for regenerative healing. A growing body of literature demonstrates that H vessels constitute a large portion of bone's innate capacity for osteogenic healing. We believe that CD31hiEmcnhi vessels play a role in bone healing during distraction osteogenesis (DO). DO is a procedure that utilizes traction forces to facilitate induction of endogenous bone formation and regeneration of surrounding soft tissues such as skin, muscle, tendon, and neurovascular structures. While the H vessel response to mechanical injury is adequate to facilitate healing in normal healthy tissue, it remains inadequate to overcome the devastation of radiation. We posit that the destruction of CD31hiEmcnhi vessels plays a role in precluding DO's effectiveness in irradiated bone defect healing. We aim, therefore, to recapitulate the normal pathway of bony healing by utilizing the regenerative capacity of H vessels. We hypothesize that using localized application of deferoxamine (DFO) will enhance the H vessel-mediated vasculogenic response to radiation damage and ultimately enable osteogenic healing during DO. This discovery could potentially be exploited by developing translational therapeutics to hopefully accelerate bone formation and shorten the DO consolidation period, thereby potentially expanding DO's utilization in irradiated bone healing. Sprague-Dawley rats were divided into three groups: DO, radiation with DO (xDO), and radiation with DO and DFO i[cell cut: 5182 characters, first 2000 kept]
rights: Thieme. All rights reserved.
has PII: sps01407
doi: 10.1055/s-0043-1778039
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Daniel M
      type: Person
      first name: Melissa
      last name: Daniel
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 2
    item: Sheppard N
      type: Person
      first name: Nathan
      last name: Sheppard
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 3
    item: Carlos G
      type: Person
      first name: Garrison
      last name: Carlos
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 4
    item: Nelson N
      type: Person
      first name: Noah
      last name: Nelson
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 5
    item: Donneys A
      type: Person
      first name: Alex
      last name: Donneys
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
  slot:
    index: 6
    item: Buchman SR
      type: Person
      first name: Steven R
      last name: Buchman
      member of: Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
created: 2024-3-18T06:42
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-18T04:15
ISSN: 1535-2188
has issn l: 1535-2188
issue: 1
has NLM journal title abbreviation: Semin Plast Surg
publication name: Seminars in plastic surgery
language: eng
has national library of medicine journal id: 101131275
derived from: NLM
starting page: 31
ending page: 38
has place of publication: United States
source: Semin Plast Surg. 2024-02;38(1):31-38.
volume: 38

Endocrinology/Primary Care Pharmacy Collaboration vs Endocrinology Care Alone in Patients With Type 2 Diabetes and A1c >9.
pmid: 38525094
abstract: Background: Type 2 diabetes (T2D) requires close collaboration between patients and their care management team, often including endocrinology. Primary care pharmacist impact on diabetes management in collaboration with endocrinology is not well established. Objective: To assess if pharmacy and endocrinology collaboration results in a greater A1c reduction in patients with T2D vs endocrinology alone. Methods: This retrospective, observational cohort study was conducted in adult outpatients with T2D and baseline A1c >9% who saw endocrinology within 1 year preceding the study period (January 1, 2021 to January 1, 2022). Patients were included if they had a follow-up A1c 6 months (±90 days) from index date and completed at least 1 endocrinology visit during the study period. Patients managed by endocrinology/primary care pharmacist collaboration (Endo/PharmD) were compared with those who received endocrinology care alone (Endo). Primary outcome was change in A1c from baseline to 6 months. Secondary outcomes included total number of completed visits and percentage of patients achieving A1c <6.5%, <7%, <8%, and <9% between groups at 6 months. Results: A total of 418 patients were included (22 Endo/PharmD, 396 Endo). The change in follow-up A1c was not significantly different between groups, -0.481% (standard error [SE] = 0.396); P = 0.6179. Endo/PharmD patients had significantly more provider visits during the study period (5.3 ± 2.3 vs 2.3 ± 1.2; P < 0.001). No significant difference was observed in odds of A1c goal attainment between groups at 6 months. Conclusion and Relevance: Endocrinology/primary care pharmacist collaboration occurred infrequently but was associated with a trend toward greater A1c reduction in patients with T2D and A1c >9%.
rights: © The Author(s) 2024.
has PII: 10.1177_87551225231224251
doi: 10.1177/87551225231224251
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Fornwald CR
      type: Person
      first name: Courtney R
      last name: Fornwald
      member of: Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 2
    item: Russo-Alvarez G
      type: Person
      first name: Giavanna
      last name: Russo-Alvarez
      member of: Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 3
    item: Pantalone KM
      type: Person
      first name: Kevin M
      last name: Pantalone
      member of: Department of Endocrinology, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 4
    item: Zeleznikar E
      type: Person
      first name: Elizabeth
      last name: Zeleznikar
      member of: Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 5
    item: Parker M
      type: Person
      first name: Marcie
      last name: Parker
      member of: Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 6
    item: McCorkindale N
      type: Person
      first name: Nicole
      last name: McCorkindale
      member of: Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 7
    item: Butler R
      type: Person
      first name: Robert
      last name: Butler
      member of: Quantitative Health Sciences Department, Learner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
  slot:
    index: 8
    item: Hermiller T
      type: Person
      first name: Taylor
      last name: Hermiller
      member of: Department of Pharmacy, Cleveland Clinic Foundation, Cleveland, OH, USA.
created: 2024-3-25T06:42
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 Apr
created: 2024-3-25T04:36
ISSN: 8755-1225
has issn l: 1549-4810
issue: 2
has NLM journal title abbreviation: J Pharm Technol
publication name: The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
language: eng
has national library of medicine journal id: 8504643
derived from: NLM
starting page: 78
ending page: 84
has place of publication: United States
source: J Pharm Technol. 2024-04;40(2):78-84.
volume: 40

http://rdf.ncbi.nlm.nih.gov/pubmed/38506226
pmid: 38506226
abstract: Chimeric antigen receptor (CAR) T cell therapy has markedly improved the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). The relative positioning of tumor lesions in lymphoma varies among patients, manifesting as either aggregation (clumped together) or dissemination (spread throughout the body). Prognostic significance of factors indicating the relative positioning of tumor lesions in CAR T cell therapy remains underexplored. For aggregation, prior research proposed the tumor volume surface ratio (TVSR), linking it to prognosis in chemotherapy. Regarding dissemination, indicators such as disease stage or extranodal involvement, commonly used in clinical practice, have not demonstrated prognostic significance in CAR T cell therapy. This study aims to analyze current indicators of tumor aggregation or dissemination and introduce a novel indicator to assess the prognostic value of tumor lesions' relative positioning in DLBCL patients undergoing CAR T cell therapy.This retrospective study included 42 patients receiving CAR T cell therapy. Lesion image information was obtained from the last PET/CT scan prior to CAR T cell infusion, including total metabolic tumor volume, total tumor surface, diameter of lymphoma masses, and the sites of tumor lesions. We evaluated TVSR and bulky disease as descriptors of tumor aggregation. We refined existing indicators, stage III&IV and >1 site extranodal involvement, to distill a new indicator, termed 'extra stage', to better represent tumor dissemination. The study examined the prognostic significance of tumor aggregation and dissemination.Our findings indicate that TVSR, while prognostically valuable in chemotherapy, lacks practical prognostic value in CAR T cell therapy. Conversely, bulky disease emerged as an optimal prognostic indicator of tumor aggregation. Both bulky disease and extra stage were associated with poor prognosis and exhibiting synergistic prognostic impact in CAR T cell therapy.Overall, the relat[cell cut: 2206 characters, first 2000 kept]
rights: © 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
doi: 10.1002/cam4.6991
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Dang X
      type: Person
      first name: Xiuyong
      last name: Dang
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 2
    item: Li P
      type: Person
      first name: Ping
      last name: Li
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 3
    item: Shen A
      type: Person
      first name: Aijun
      last name: Shen
      member of: Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 4
    item: Lu Y
      type: Person
      first name: Yan
      last name: Lu
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 5
    item: Zhu Z
      type: Person
      first name: Zeyv
      last name: Zhu
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 6
    item: Zhang M
      type: Person
      first name: Min
      last name: Zhang
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 7
    item: Qian W
      type: Person
      first name: Wenbin
      last name: Qian
      member of: Department of Hematology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  slot:
    index: 8
    item: Liang A
      type: Person
      first name: Aibin
      last name: Liang
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  slot:
    index: 9
    item: Zhang W
      type: Person
      first name: Wenjun
      last name: Zhang
      member of: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
created: 2024-3-20T12:44
date last updated: 2025-01-20
issued: 2024-03
dp: 2024 Mar
created: 2024-3-20T06:23
e ISSN: 2045-7634
has issn l: 2045-7634
issue: 6
has NLM journal title abbreviation: Cancer Med
publication name: Cancer medicine
language: eng
has national library of medicine journal id: 101595310
derived from: NLM
pg: e6991
has place of publication: United States
has primary subject term: D000076962Q000627
has primary subject term: D016403Q000188
has subject term: D006801
has subject term: D016219Q000379
has subject term: http://id.nlm.nih.gov/mesh/D000072078
has subject term: D012189
has subject term: D011379
has subject term: D064987
source: Cancer Med. 2024-03;13(6):e6991.
title: Indicators describing the tumor lesion aggregation and dissemination and their impact on the prognosis of patients with diffuse large B cell lymphoma receiving chimeric antigen receptor T cell therapy.
volume: 13

Brevipalpus yothersi Baker (Tenuipalpidae) development in sweet orange plants is influenced by previous mite infestation and the presence of shelters.
pmid: 38512422
abstract: Citrus leprosis is the most important viral disease affecting citrus. The disease is caused predominantly by CiLV-C and is transmitted by Brevipalpus yothersi Baker mites. This study brings some insight into the colonization of B. yothersi in citrus [(Citrus × sinensis (L.) Osbeck (Rutaceae)] previously infested by viruliferous or non-viruliferous B. yothersi. It also assesses the putative role of shelters on the behavior of B. yothersi. Expression of PR1 and PR4 genes, markers of plant defense mechanisms, were evaluated by RT-qPCR to correlate the role of the plant hormonal changes during the tri-trophic virus-mite-plant interplay. A previous infestation with either non-viruliferous and viruliferous mites positively influenced oviposition and the number of adult individuals in the resulting populations. Mite populations were higher on branches that had received a previous mite infestation than branches that did not. There was an increase in the expression of PR4, a marker gene in the jasmonic acid (JA) pathway, in the treatment with non-viruliferous mites, indicating a response from the plant to their feeding. Conversely, an induced expression of PR1, a marker gene in the salicylic acid (SA) pathway, was observed mainly in the treatment with viruliferous mites, which suggests the activation of a plant response against the pathogen. The earlier mite infestation, as well as the presence of leprosis lesions and a gypsum mixture as artificial shelters, all fostered the growth of the B. yothersi populations after the second infestation, regardless of the presence or absence of CiLV-C. Furthermore, it is suggested that B. yothersi feeding actually induces the JA pathway in plants. At the same time, the CiLV-C represses the JA pathway and induces the SA pathway, which benefits the mite vector.
rights: © 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
has PII: 10.1007/s10493-024-00903-w
doi: 10.1007/s10493-024-00903-w
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Kapp ABP
      type: Person
      first name: Ana Beatriz Piai
      last name: Kapp
      member of: Laboratório de Acarologia (AcaroLab), Faculdade de Ciências Agrárias e Veterinárias (FCAV-Unesp), Universidade Estadual Paulista, Via de Acesso Prof. Paulo Donato Castellane s/nº, Jaboticabal, São Paulo, CEP 14884-900, Brazil.
  slot:
    index: 2
    item: Vechia JFD
      type: Person
      first name: Jaqueline Franciosi Della
      last name: Vechia
      member of: Laboratório de Acarologia (AcaroLab), Faculdade de Ciências Agrárias e Veterinárias (FCAV-Unesp), Universidade Estadual Paulista, Via de Acesso Prof. Paulo Donato Castellane s/nº, Jaboticabal, São Paulo, CEP 14884-900, Brazil.
  slot:
    index: 3
    item: Sinico TE
      type: Person
      first name: Thaís Elise
      last name: Sinico
      member of: Instituto Biológico/IB, São Paulo, São Paulo, 04014-002, Brazil.Centro de Citricultura Sylvio Moreira/IAC, Cordeirópolis, São Paulo, 13490-970, Brazil.
  slot:
    index: 4
    item: Bassanezi RB
      type: Person
      first name: Renato Beozzo
      last name: Bassanezi
      member of: Fundo de Defesa da Citricultura/Fundecitrus, Araraquara, São Paulo, 14807-040, Brazil.
  slot:
    index: 5
    item: Ramos-González PL
      type: Person
      first name: Pedro Luis
      last name: Ramos-González
      member of: Instituto Biológico/IB, São Paulo, São Paulo, 04014-002, Brazil.
  slot:
    index: 6
    item: Freitas-Astúa J
      type: Person
      first name: Juliana
      last name: Freitas-Astúa
      member of: Instituto Biológico/IB, São Paulo, São Paulo, 04014-002, Brazil.Embrapa Mandioca e Fruticultura, Cruz das Almas, Bahia, 44380-000, Brazil.
  slot:
    index: 7
    item: Andrade DJ
      type: Person
      first name: Daniel Júnior
      last name: Andrade
      member of: Laboratório de Acarologia (AcaroLab), Faculdade de Ciências Agrárias e Veterinárias (FCAV-Unesp), Universidade Estadual Paulista, Via de Acesso Prof. Paulo Donato Castellane s/nº, Jaboticabal, São Paulo, CEP 14884-900, Brazil. daniel.andrade@unesp.br.
created: 2024-3-21T18:45
date last updated: 2025-01-20
issued: 2024-05
dp: 2024 May
created: 2024-3-21T12:05
e ISSN: 1572-9702
has issn l: 0168-8162
issue: 4
has NLM journal title abbreviation: Exp Appl Acarol
publication name: Experimental & applied acarology
language: eng
has national library of medicine journal id: 8507436
derived from: NLM
starting page: 759
ending page: 775
has place of publication: Netherlands
has primary subject term: D008925Q000502
has primary subject term: D032084
has subject term: D000818
has subject term: D010935Q000469
has subject term: D005260
has subject term: D008924Q000662Q000469
has subject term: D010058
source: Exp Appl Acarol. 2024-05;92(4):759-775.
volume: 92

Use of noninvasive imaging to identify causes of skeletal fragility in adults with diabetes: a review.
pmid: 38505529
abstract: Diabetes, a disease marked by consistent high blood glucose levels, is associated with various complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease. Notably, skeletal fragility has emerged as a significant complication in both type 1 (T1D) and type 2 (T2D) diabetic patients. This review examines noninvasive imaging studies that evaluate skeletal outcomes in adults with T1D and T2D, emphasizing distinct skeletal phenotypes linked with each condition and pinpointing gaps in understanding bone health in diabetes. Although traditional DXA-BMD does not fully capture the increased fracture risk in diabetes, recent techniques such as quantitative computed tomography, peripheral quantitative computed tomography, high-resolution quantitative computed tomography, and MRI provide insights into 3D bone density, microstructure, and strength. Notably, existing studies present heterogeneous results possibly due to variations in design, outcome measures, and potential misclassification between T1D and T2D. Thus, the true nature of diabetic skeletal fragility is yet to be fully understood. As T1D and T2D are diverse conditions with heterogeneous subtypes, future research should delve deeper into skeletal fragility by diabetic phenotypes and focus on longitudinal studies in larger, diverse cohorts to elucidate the complex influence of T1D and T2D on bone health and fracture outcomes.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.
has PII: ziae003
doi: 10.1093/jbmrpl/ziae003
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Emerzian SR
      type: Person
      first name: Shannon R
      last name: Emerzian
      member of: Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, United States.
  slot:
    index: 2
    item: Johannesdottir F
      type: Person
      first name: Fjola
      last name: Johannesdottir
      member of: Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, United States.
  slot:
    index: 3
    item: Yu EW
      type: Person
      first name: Elaine W
      last name: Yu
      member of: Department of Medicine, Endocrine Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
  slot:
    index: 4
    item: Bouxsein ML
      type: Person
      first name: Mary L
      last name: Bouxsein
      member of: Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, United States.Department of Medicine, Endocrine Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.
created: 2024-3-20T06:46
date last updated: 2025-01-20
issued: 2024-02
dp: 2024 Feb
created: 2024-3-20T04:12
e ISSN: 2473-4039
has issn l: 2473-4039
issue: 2
has NLM journal title abbreviation: JBMR Plus
publication name: JBMR plus
language: eng
has national library of medicine journal id: 101707013
derived from: NLM
pg: ziae003
has place of publication: England
source: JBMR Plus. 2024-02;8(2):ziae003.
volume: 8

Dust and Death: Evidence from the West African Harmattan.
pmid: 38505244
abstract: Using two decades of data from 12 low-income countries in West Africa, we show that dust carried by harmattan trade winds increases infant and child mortality. Health investments respond to dust exposure, consistent with compensating behaviours. Despite these efforts, surviving children still exhibit negative health impacts. Our data allow us to investigate differential impacts over time and across countries. We find declining impacts over time, suggesting adaptation. Using national-level measures of macroeconomic conditions and health resources, we find suggestive evidence that both economic development and public health improvements have contributed to this adaptation, with health improvements playing a larger role.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of Royal Economic Society.
has PII: uead088
doi: 10.1093/ej/uead088
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Adhvaryu A
      type: Person
      first name: Achyuta
      last name: Adhvaryu
      member of: University of California San Diego, USA.
  slot:
    index: 2
    item: Bharadwaj P
      type: Person
      first name: Prashant
      last name: Bharadwaj
      member of: University of California San Diego, USA.
  slot:
    index: 3
    item: Fenske J
      type: Person
      first name: James
      last name: Fenske
      member of: University of Warwick, UK.
  slot:
    index: 4
    item: Nyshadham A
      type: Person
      first name: Anant
      last name: Nyshadham
      member of: University of Michigan, USA.
  slot:
    index: 5
    item: Stanley R
      type: Person
      first name: Richard
      last name: Stanley
      member of: PATH, USA.
created: 2024-3-20T06:46
date last updated: 2025-01-20
issued: 2024-04
dp: 2024 Apr
created: 2024-3-20T04:06
ISSN: 0013-0133
has issn l: 0013-0133
issue: 659
has NLM journal title abbreviation: Econ J (London)
publication name: Economic journal (London, England)
language: eng
has national library of medicine journal id: 101518442
derived from: NLM
starting page: 885
ending page: 912
has place of publication: England
source: Econ J (London). 2024-04;134(659):885-912.
volume: 134

Development of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities.
pmid: 38516588
abstract: Inhibition of the Hsp90 C-terminal domain offers a promising opportunity to treat numerous diseases/indications. Furthermore, the development of Hsp90 C-terminal inhibitors (CTIs) is advantageous over N-terminal inhibitors because it avoids the detriments associated with induction of the heat shock response (HSR). However, the lack of co-crystal structures of small molecules bound to the C-terminus have hindered their development. Therefore, structure-activity relationship (SAR) studies have been pursued to optimize such inhibitors. Noviose sugar surrogates, also known as noviomimetics have been prepared to investigate the size and nature of the C-terminal domain binding pocket. Herein, we report the synthesis and anti-proliferative activity manifested by this new series of Hsp90 C-terminal inhibitors.
rights: This journal is © The Royal Society of Chemistry.
has PII: d3md00529a
doi: 10.1039/d3md00529a
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Amatya E
      type: Person
      first name: Eva
      last name: Amatya
      member of: Department of Chemistry and Biochemistry, Warren Center for Drug Discovery, University of Notre Dame Notre Dame Indiana 46556 USA bblagg@nd.edu.
  slot:
    index: 2
    item: Subramanian C
      type: Person
      first name: Chitra
      last name: Subramanian
      member of: Cancer Center at Illinois, University of Illinois Urbana-Champaign Urbana Illinois 61801 USA.
  slot:
    index: 3
    item: Cohen MS
      type: Person
      first name: Mark S
      last name: Cohen
      member of: Cancer Center at Illinois, University of Illinois Urbana-Champaign Urbana Illinois 61801 USA.
  slot:
    index: 4
    item: Blagg BSJ
      type: Person
      first name: Brian S J
      last name: Blagg
      member of: Department of Chemistry and Biochemistry, Warren Center for Drug Discovery, University of Notre Dame Notre Dame Indiana 46556 USA bblagg@nd.edu.
created: 2024-3-22T06:45
date last updated: 2025-01-20
issued: 2024-03-20
dp: 2024 Mar 20
created: 2024-3-22T04:16
e ISSN: 2632-8682
has issn l: 2632-8682
issue: 3
has NLM journal title abbreviation: RSC Med Chem
publication name: RSC medicinal chemistry
language: eng
has national library of medicine journal id: 101759460
derived from: NLM
starting page: 888
ending page: 894
has place of publication: England
source: RSC Med Chem. 2024-03-20;15(3):888-894.
volume: 15

Ethnic Differences in Muslim Women's Mental Health Beliefs, Rejection Attitudes, and Familiarity with Professional Mental Healthcare.
pmid: 38585328
abstract: Prior work on Muslims' mental health help-seeking factors has emphasized their rejection attitudes, religious and cultural beliefs, and familiarity with mental health (Aloud & Rathur, 2009; Ali et al., 2021). However, no research has examined differences in these factors across different Muslim ethnic groups, and particularly among Muslim women. 1214 Muslim women living in the USA completed online questionnaires. Data was stratified based on history of mental health visits to control for previous service utilization. MANOVAs assessed ethnic group differences in beliefs, familiarity, and rejection attitudes toward professional mental healthcare. Results revealed significant differences between ethnic groups in all three factors; these differences depended on the women's history of service utilization. Findings suggest that barriers to accessing professional mental healthcare differ among Muslim ethnic groups. Results are discussed in light of clinical implications and other contributing factors to the underutilization of professional mental healthcare among ethnically diverse American Muslim women.
doi: 10.1080/13674676.2023.2243459
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Elahi S
      type: Person
      first name: Saadia
      last name: Elahi
      member of: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, USA.
  slot:
    index: 2
    item: Elsayed D
      type: Person
      first name: Danah
      last name: Elsayed
      member of: Department of Family Relations and Applied Nutrition, University of Guelph, Canada.
  slot:
    index: 3
    item: Ali S
      type: Person
      first name: Sara
      last name: Ali
      member of: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA.
  slot:
    index: 4
    item: Awaad R
      type: Person
      first name: Rania
      last name: Awaad
      member of: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA.
created: 2023-1-1T00:00
date last updated: 2025-01-20
issued: 2023
dp: 2023
created: 2024-4-8T04:28
ISSN: 1367-4676
has issn l: 1367-4676
issue: 9
has NLM journal title abbreviation: Ment Health Relig Cult
publication name: Mental health, religion & culture
language: eng
has national library of medicine journal id: 9814576
derived from: NLM
starting page: 890
ending page: 907
has place of publication: England
source: Ment Health Relig Cult. 2023;26(9):890-907.
volume: 26

Definition: Orientation agnosia.
pmid: 38594164
has PII: S0010-9452(24)00081-9
doi: 10.1016/j.cortex.2024.03.006
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Beschin N
      type: Person
      first name: Nicoletta
      last name: Beschin
      member of: Neuropsychological and Cognitive Rehabilitation Service, Rehabilitation Unit & Clinical Psychology Unit, ASST Valle Olona, Varese, Italy. Electronic address: nicoletta.beschin@gmail.com.
  slot:
    index: 2
    item: Turnbull OH
      type: Person
      first name: Oliver H
      last name: Turnbull
      member of: Department of Psychology, Bangor University, Bangor, Wales, UK.
created: 2024-4-10T00:42
date last updated: 2025-01-19
issued: 2025-01
dp: 2025 Jan
created: 2024-4-9T22:03
e ISSN: 1973-8102
has issn l: 0010-9452
has NLM journal title abbreviation: Cortex
publication name: Cortex; a journal devoted to the study of the nervous system and behavior
language: eng
has national library of medicine journal id: 0100725
derived from: NLM
pg: 216
has place of publication: Italy
source: Cortex. 2025-01;182():216.
volume: 182

Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.
pmid: 38618952
abstract: N6-Methyladenosine (m6A) is the most abundant posttranscriptional modification, and its contribution to cancer evolution has recently been appreciated. Renal cancer is the most common adult genitourinary cancer, approximately 85% of which is accounted for by the clear cell renal cell carcinoma (ccRCC) subtype characterized by VHL loss. However, it is unclear whether VHL loss in ccRCC affects m6A patterns. In this study, we demonstrate that VHL binds and promotes METTL3/METTL14 complex formation while VHL depletion suppresses m6A modification, which is distinctive from its canonical E3 ligase role. m6A RNA immunoprecipitation sequencing (RIP-Seq) coupled with RNA-Seq allows us to identify a selection of genes whose expression may be regulated by VHL-m6A signaling. Specifically, PIK3R3 is identified to be a critical gene whose mRNA stability is regulated by VHL in a m6A-dependent but HIF-independent manner. Functionally, PIK3R3 depletion promotes renal cancer cell growth and orthotopic tumor growth while its overexpression leads to decreased tumorigenesis. Mechanistically, the VHL-m6A-regulated PIK3R3 suppresses tumor growth by restraining PI3K/AKT activity. Taken together, we propose a mechanism by which VHL regulates m6A through modulation of METTL3/METTL14 complex formation, thereby promoting PIK3R3 mRNA stability and protein levels that are critical for regulating ccRCC tumorigenesis.
has PII: 175703
doi: 10.1172/JCI175703
creator: OrderedList
  length: 20
  slot:
    index: 1
    item: Zhang C
      type: Person
      first name: Cheng
      last name: Zhang
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 2
    item: Yu M
      type: Person
      first name: Miaomiao
      last name: Yu
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 3
    item: Hepperla AJ
      type: Person
      first name: Austin J
      last name: Hepperla
      member of: Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) School of Medicine, Chapel Hill, North Carolina, USA.Department of Genetics, Neuroscience Center and.UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, UNC, Chapel Hill, North Carolina, USA.
  slot:
    index: 4
    item: Zhang Z
      type: Person
      first name: Zhao
      last name: Zhang
      member of: Department of Molecular Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  slot:
    index: 5
    item: Raj R
      type: Person
      first name: Rishi
      last name: Raj
      member of: Department of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center and.
  slot:
    index: 6
    item: Zhong H
      type: Person
      first name: Hua
      last name: Zhong
      member of: Department of Pathology, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 7
    item: Zhou J
      type: Person
      first name: Jin
      last name: Zhou
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 8
    item: Hu L
      type: Person
      first name: Lianxin
      last name: Hu
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 9
    item: Fang J
      type: Person
      first name: Jun
      last name: Fang
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 10
    item: Liu H
      type: Person
      first name: Hongyi
      last name: Liu
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 11
    item: Liang Q
      type: Person
      first name: Qian
      last name: Liang
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 12
    item: Jia L
      type: Person
      first name: Liwei
      last name: Jia
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 13
    item: Liao C
      type: Person
      first name: Chengheng
      last name: Liao
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  slot:
    index: 14
    item: Xi S
      type: Person
      first name: Sichuan
      last name: Xi
      member of: Thoracic Epigenetics Section, Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  slot:
    index: 15
    item: Simon JM
      type: Person
      first name: Jeremy M
      last name: Simon
      member of: Lineberger Comprehensive Cancer Center, University of North Carolina (UNC) School of Medicine, Chapel Hill, North Carolina, USA.Department of Genetics, Neuroscience Center and.UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, UNC, Chapel Hill, North Carolina, USA.
  slot:
    index: 16
    item: Xu K
      type: Person
      first name: Kexin
      last name: Xu
      member of: Department of Molecular Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  slot:
    index: 17
    item: Liu Z
      type: Person
      first name: Zhijie
      last name: Liu
      member of: Department of Molecular Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  slot:
    index: 18
    item: Nam Y
      type: Person
      first name: Yunsun
      last name: Nam
      member of: Department of Biochemistry, Department of Biophysics, Simmons Comprehensive Cancer Center and.
  slot:
    index: 19
    item: Kapur P
      type: Person
      first name: Payal
      last name: Kapur
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.Kidney Cancer Program, Simmons Comprehensive Cancer Center, Department of Urology.
  slot:
    index: 20
    item: Zhang Q
      type: Person
      first name: Qing
      last name: Zhang
      member of: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
created: 2024-4-15T12:44
date last updated: 2025-01-20
issued: 2024-04-15
dp: 2024 Apr 15
created: 2024-4-15T06:03
e ISSN: 1558-8238
has issn l: 0021-9738
issue: 8
has NLM journal title abbreviation: J Clin Invest
publication name: The Journal of clinical investigation
language: eng
has national library of medicine journal id: 7802877
derived from: NLM
has place of publication: United States
has primary subject term: D000225
has primary subject term: D002292Q000235
has primary subject term: D007680Q000235
has subject term: D000328
has subject term: D006801
has subject term: D063646Q000235
has subject term: D002471
has subject term: D015870
has subject term: D008780Q000235
has subject term: D019869Q000235
source: J Clin Invest. 2024-04-15;134(8):.
volume: 134

[Priapism].
pmid: 38653788
abstract: Priapism is defined as penile erection lasting more than four hours that is unrelated to sexual arousal. Priapism is classified based on the oxygenation of the penile tissue into ischemic and non-ischemic subtypes. As the most common form, ischemic priapism is usually associated with pain and carries a significant risk of permanent loss of erectile function; thus, rapid intervention is necessary. Initial therapy consists of corporal aspiration and injection of sympathomimetic agents. If detumescence is not achieved, a cavernosal shunt is necessary. Non-ischemic priapism is less common than the ischemic type and is usually the result of perineal trauma. In this subtype, there is usually no pain and treatment is initially conservative. Recurrent (stuttering) priapism is a variant of the ischemic subtype, but is self-limiting and usually occurs during sleep with a duration of less than three to four hours. In the case of prolonged erection, therapy is analogous to that of the ischemic subtype.
rights: © 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
has PII: 10.1007/s00120-024-02338-y
doi: 10.1007/s00120-024-02338-y
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Rosellen J
      type: Person
      first name: Jens
      last name: Rosellen
      member of: Klinik für Urologie, Kinderurologie und Andrologie, Justus Liebig Universität, Rudolf-Buchheim-Straße 8, 35392, Gießen, Deutschland. jens.rosellen@uk-gm.de.
  slot:
    index: 2
    item: Hauptmann A
      type: Person
      first name: Arne
      last name: Hauptmann
      member of: Klinik für Urologie, Kinderurologie und Andrologie, Justus Liebig Universität, Rudolf-Buchheim-Straße 8, 35392, Gießen, Deutschland.
  slot:
    index: 3
    item: Wagenlehner F
      type: Person
      first name: Florian
      last name: Wagenlehner
      member of: Klinik für Urologie, Kinderurologie und Andrologie, Justus Liebig Universität, Rudolf-Buchheim-Straße 8, 35392, Gießen, Deutschland.
  slot:
    index: 4
    item: Diemer T
      type: Person
      first name: Thorsten
      last name: Diemer
      member of: Klinik für Urologie, Kinderurologie und Andrologie, Justus Liebig Universität, Rudolf-Buchheim-Straße 8, 35392, Gießen, Deutschland.
created: 2024-4-24T01:43
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-4-23T23:17
e ISSN: 2731-7072
has issn l: 2731-7064
issue: 6
has NLM journal title abbreviation: Urologie
publication name: Urologie (Heidelberg, Germany)
language: ger
has national library of medicine journal id: 9918384886606676
rights holder: Der Priapismus ist definiert als eine penile Erektion über mehr als 4 h Dauer unabhängig von einer sexuellen Erregung. Hierbei erfolgt abhängig von der Oxygenierung des penilen Gewebes eine Klassifizierung in einen ischämischen und nicht-ischämischen Subtyp. Der ischämische Priapismus ist als häufigste Form meist mit Schmerzen assoziiert und birgt bei verzögertem Therapiebeginn ein erhebliches Risiko für einen permanenten Verlust der Erektionsfähigkeit. Die initiale Therapie besteht in der korporalen Aspiration und Injektion von Sympathomimetika. Bei Nichterreichen einer Detumeszenz ist ein kavernosaler Shunt notwendig. Ein nicht-ischämischer Priapismus ist seltener als der ischämische Typ und meist Folge eines perinealen Traumas. Bei diesem Subtyp liegen meist keine Schmerzen vor und die Therapie erfolgt zunächst konservativ. Ein rekurrenter („stuttering“) Priapismus ist eine Variante des ischämischen Subtyps, aber selbstlimitierend und meist im Schlaf auftretend mit einer Dauer unter 3 bis 4 h. Bei einer prolongierten Erektion erfolgt hier eine Therapie analog zu der des ischämischen Subtyps.
derived from: NLM
starting page: 566
ending page: 572
has place of publication: Germany
has primary subject term: D011317Q000628Q000209Q000175Q000503
has subject term: D006801
has subject term: D008297
has subject term: D010413Q000098
source: Urologie. 2024-06;63(6):566-572.
volume: 63

Comparison of bamlanivimab with or without etesevimab and casirivimab-imdevimab in clinical outcomes in patients with COVID-19: a systematic review and meta-analysis.
pmid: 38721976
doi: 10.1080/1120009X.2024.2352268
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yang M
      type: Person
      first name: Mingyang
      last name: Yang
      member of: Department of Emergency and Critical Care Medicine, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.Health Emergency Management Research Center, China-PUMC C.C. Chen Institute of Health, Sichuan University.
  slot:
    index: 2
    item: Liu J
      type: Person
      first name: Junzhao
      last name: Liu
      member of: Department of Emergency and Critical Care Medicine, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.Health Emergency Management Research Center, China-PUMC C.C. Chen Institute of Health, Sichuan University.
  slot:
    index: 3
    item: Luo L
      type: Person
      first name: Linna
      last name: Luo
      member of: Department of Emergency and Critical Care Medicine, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.Health Emergency Management Research Center, China-PUMC C.C. Chen Institute of Health, Sichuan University.
  slot:
    index: 4
    item: Dai K
      type: Person
      first name: Kaili
      last name: Dai
      member of: Department of Emergency and Critical Care Medicine, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.Health Emergency Management Research Center, China-PUMC C.C. Chen Institute of Health, Sichuan University.
created: 2024-5-9T14:26
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2024-5-9T07:33
e ISSN: 1973-9478
has issn l: 1120-009X
issue: 1
has NLM journal title abbreviation: J Chemother
publication name: Journal of chemotherapy (Florence, Italy)
language: eng
has national library of medicine journal id: 8907348
derived from: NLM
starting page: 94
ending page: 96
has place of publication: England
source: J Chemother. 2025-02;37(1):94-96.
volume: 37

Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches.
pmid: 38737610
abstract: Glioblastoma (GBM) poses therapeutic challenges due to its aggressive nature, particularly for patients with poor functional status and/or advanced disease. Hypofractionated radiotherapy (RT) regimens have demonstrated comparable disease outcomes for this population while allowing treatment to be completed more quickly. Here, we report our institutional outcomes of patients treated with 2 hypofractionated RT regimens: 40 Gy/15fx (3w-RT) and 50 Gy/20fx (4w-RT).A single-institution retrospective analysis was conducted of 127 GBM patients who underwent 3w-RT or 4w-RT. Patient characteristics, treatment regimens, and outcomes were analyzed. Univariate and multivariable Cox regression models were used to estimate progression-free survival (PFS) and overall survival (OS). The impact of chemotherapy and RT schedule was explored through subgroup analyses.Median OS for the entire cohort was 7.7 months. There were no significant differences in PFS or OS between 3w-RT and 4w-RT groups overall. Receipt and timing of temozolomide (TMZ) emerged as the variable most strongly associated with survival, with patients receiving adjuvant-only or concurrent and adjuvant TMZ having significantly improved PFS and OS (P < .001). In a subgroup analysis of patients that did not receive TMZ, patients in the 4w-RT group demonstrated a trend toward improved OS as compared to the 3w-RT group (P = .12).This study demonstrates comparable survival outcomes between 3w-RT and 4w-RT regimens in GBM patients. Receipt and timing of TMZ were strongly associated with survival outcomes. The potential benefit of dose-escalated hypofractionation for patients not receiving chemotherapy warrants further investigation and emphasizes the importance of personalized treatment approaches.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: npae004
doi: 10.1093/nop/npae004
creator: OrderedList
  length: 18
  slot:
    index: 1
    item: Beckham TH
      type: Person
      first name: Thomas H
      last name: Beckham
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 2
    item: Rooney MK
      type: Person
      first name: Michael K
      last name: Rooney
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 3
    item: McAleer MF
      type: Person
      first name: Mary F
      last name: McAleer
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 4
    item: Ghia AJ
      type: Person
      first name: Amol J
      last name: Ghia
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 5
    item: Tom MC
      type: Person
      first name: Martin C
      last name: Tom
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 6
    item: Perni S
      type: Person
      first name: Subha
      last name: Perni
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 7
    item: McGovern S
      type: Person
      first name: Susan
      last name: McGovern
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 8
    item: Grosshans D
      type: Person
      first name: David
      last name: Grosshans
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 9
    item: Chung C
      type: Person
      first name: Caroline
      last name: Chung
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 10
    item: Wang C
      type: Person
      first name: Chenyang
      last name: Wang
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 11
    item: De B
      type: Person
      first name: Brain
      last name: De
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 12
    item: Swanson T
      type: Person
      first name: Todd
      last name: Swanson
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 13
    item: Paulino A
      type: Person
      first name: Arnold
      last name: Paulino
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 14
    item: Jiang W
      type: Person
      first name: Wen
      last name: Jiang
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 15
    item: Ferguson S
      type: Person
      first name: Sherise
      last name: Ferguson
      member of: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 16
    item: Patel CB
      type: Person
      first name: Chirag B
      last name: Patel
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 17
    item: Li J
      type: Person
      first name: Jing
      last name: Li
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  slot:
    index: 18
    item: Yeboa DN
      type: Person
      first name: Debra N
      last name: Yeboa
      member of: Department of Radiation Oncology, CNS/Pediatrics Section, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
created: 2024-5-13T06:42
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-5-13T04:17
ISSN: 2054-2577
has issn l: 2054-2577
issue: 3
has NLM journal title abbreviation: Neurooncol Pract
publication name: Neuro-oncology practice
language: eng
has national library of medicine journal id: 101640528
derived from: NLM
starting page: 266
ending page: 274
has place of publication: England
source: Neurooncol Pract. 2024-06;11(3):266-274.
volume: 11

Multimodal imaging with magnetization transfer and diffusion tensor imaging reveals evidence of myelin damage in children and youth treated for a brain tumor.
pmid: 38737604
abstract: The microstructural damage underlying compromise of white matter following treatment for pediatric brain tumors is unclear. We use multimodal imaging employing advanced diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI) MRI methods to examine chronic microstructural damage to white matter in children and adolescents treated for pediatric brain tumor. Notably, MTI may be more sensitive to macromolecular content, including myelin, than DTI.Fifty patients treated for brain tumors (18 treated with surgery ± chemotherapy and 32 treated with surgery followed by cranial-spinal radiation; time from diagnosis to scan ~6 years) and 45 matched healthy children completed both MTI and DTI scans. Voxelwise and region-of-interest approaches were employed to compare white matter microstructure metrics (magnetization transfer ratio (MTR); DTI- fractional anisotropy [FA], radial diffusivity [RD], axial diffusivity [AD], mean diffusivity [MD]) between patients and healthy controls.MTR was decreased across multiple white matter tracts in patients when compared to healthy children, P < .001. These differences were observed for both patients treated with radiation and those treated with only surgery, P < .001. We also found that children and adolescents treated for brain tumors exhibit decreased FA and increased RD/AD/MD compared to their healthy counterparts in several white matter regions, Ps < .02. Finally, we observed that MTR and DTI metrics were related to multiple white matter tracts in patients, Ps < .01, but not healthy control children.Our findings provide evidence that the white matter damage observed in patients years after treatment of pediatric posterior fossa tumors, likely reflects myelin disruption.
rights: © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
has PII: npae003
doi: 10.1093/nop/npae003
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Skocic J
      type: Person
      first name: Jovanka
      last name: Skocic
      member of: Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
  slot:
    index: 2
    item: Richard L
      type: Person
      first name: Logan
      last name: Richard
      member of: Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
  slot:
    index: 3
    item: Ferkul A
      type: Person
      first name: Ashley
      last name: Ferkul
      member of: Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
  slot:
    index: 4
    item: Cox E
      type: Person
      first name: Elizabeth
      last name: Cox
      member of: Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  slot:
    index: 5
    item: Tseng J
      type: Person
      first name: Julie
      last name: Tseng
      member of: Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
  slot:
    index: 6
    item: Laughlin S
      type: Person
      first name: Suzanne
      last name: Laughlin
      member of: Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  slot:
    index: 7
    item: Bouffet E
      type: Person
      first name: Eric
      last name: Bouffet
      member of: Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
  slot:
    index: 8
    item: Mabbott DJ
      type: Person
      first name: Donald James
      last name: Mabbott
      member of: Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
created: 2024-5-13T06:42
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-5-13T04:17
ISSN: 2054-2577
has issn l: 2054-2577
issue: 3
has NLM journal title abbreviation: Neurooncol Pract
publication name: Neuro-oncology practice
language: eng
has national library of medicine journal id: 101640528
derived from: NLM
starting page: 307
ending page: 318
has place of publication: England
source: Neurooncol Pract. 2024-06;11(3):307-318.
volume: 11

Inactivation of Cronobacter sakazakii in powdered infant formula with probiotics and metagenomic analysis.
pmid: 38752114
abstract: In the present study, proper manual for powdered infant formula with probiotics (PIF-P) to prevent the contamination of Cronobacter sakazakii was investigated. First, the population of C. sakazakii and LAB in three different PIF-P samples were quantitatively analyzed after reconstituted with hydrothermal treatments. When C. sakazakii was inoculated into reconstituted infant formula with probiotics (RIF-P), it was immediately reduced below the detection limit by 60-65 °C hydrothermal treatment whereas reduction levels of LAB was 1-2 log CFU/g. When heat resistance of C. sakazakii inoculated to PIF-P with 4 h drying was compared with that inoculated to RIF-P samples, the heat resistance of C. sakazakii increased significantly after the inoculation in PIF-P with drying. Metagenomic analysis revealed that Lactobacillus and Bifidobacterium were dominant genus in all three groups and there was no significant difference in the microbial community of untreated PIF sample and hydrothermal treated samples.The online version contains supplementary material available at 10.1007/s10068-023-01503-x.
rights: © The Korean Society of Food Science and Technology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 1503
doi: 10.1007/s10068-023-01503-x
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Lee JY
      type: Person
      first name: Ji-Yeon
      last name: Lee
      member of: Department of Food Engineering, Dankook University, Cheonan, Chungnam 31116 Republic of Korea.
  slot:
    index: 2
    item: Kwon EA
      type: Person
      first name: Eun-Ae
      last name: Kwon
      member of: Department of Food Engineering, Dankook University, Cheonan, Chungnam 31116 Republic of Korea.
  slot:
    index: 3
    item: Kim SS
      type: Person
      first name: Sang-Soon
      last name: Kim
      member of: Department of Food Engineering, Dankook University, Cheonan, Chungnam 31116 Republic of Korea.
created: 2024-5-16T06:42
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-5-16T03:55
e ISSN: 2092-6456
has issn l: 1226-7708
issue: 8
has NLM journal title abbreviation: Food Sci Biotechnol
publication name: Food science and biotechnology
language: eng
has national library of medicine journal id: 9816587
derived from: NLM
starting page: 1985
ending page: 1996
has place of publication: Korea (South)
source: Food Sci Biotechnol. 2024-06;33(8):1985-1996.
volume: 33

ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling.
pmid: 38816354
abstract: ARID1B haploinsufficiency in humans causes Coffin-Siris syndrome, associated with developmental delay, facial dysmorphism, and intellectual disability. The role of ARID1B has been widely studied in neuronal development, but whether it also regulates stem cells remains unknown. Here, we employ scRNA-seq and scATAC-seq to dissect the regulatory functions and mechanisms of ARID1B within mesenchymal stem cells (MSCs) using the mouse incisor model. We reveal that loss of Arid1b in the GLI1+ MSC lineage disturbs MSCs' quiescence and leads to their proliferation due to the ectopic activation of non-canonical Activin signaling via p-ERK. Furthermore, loss of Arid1b upregulates Bcl11b, which encodes a BAF complex subunit that modulates non-canonical Activin signaling by directly regulating the expression of activin A subunit, Inhba. Reduction of Bcl11b or non-canonical Activin signaling restores the MSC population in Arid1b mutant mice. Notably, we have identified that ARID1B suppresses Bcl11b expression via specific binding to its third intron, unveiling the direct inter-regulatory interactions among BAF subunits in MSCs. Our results demonstrate the vital role of ARID1B as an epigenetic modifier in maintaining MSC homeostasis and reveal its intricate mechanistic regulatory network in vivo, providing novel insights into the linkage between chromatin remodeling and stem cell fate determination.
rights: © 2024. The Author(s).
has PII: 10.1038/s41467-024-48285-2
doi: 10.1038/s41467-024-48285-2
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Zhang M
      type: Person
      first name: Mingyi
      last name: Zhang
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 2
    item: Guo T
      type: Person
      first name: Tingwei
      last name: Guo
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 3
    item: Pei F
      type: Person
      first name: Fei
      last name: Pei
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 4
    item: Feng J
      type: Person
      first name: Jifan
      last name: Feng
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 5
    item: Jing J
      type: Person
      first name: Junjun
      last name: Jing
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 6
    item: Xu J
      type: Person
      first name: Jian
      last name: Xu
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 7
    item: Yamada T
      type: Person
      first name: Takahiko
      last name: Yamada
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 8
    item: Ho TV
      type: Person
      first name: Thach-Vu
      last name: Ho
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 9
    item: Du J
      type: Person
      first name: Jiahui
      last name: Du
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 10
    item: Sehgal P
      type: Person
      first name: Prerna
      last name: Sehgal
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA.
  slot:
    index: 11
    item: Chai Y
      type: Person
      first name: Yang
      last name: Chai
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, 90033, USA. ychai@usc.edu.
created: 2024-5-31T00:42
date last updated: 2025-01-20
issued: 2024-05-30
dp: 2024 May 30
created: 2024-5-30T23:14
e ISSN: 2041-1723
has issn l: 2041-1723
issue: 1
has NLM journal title abbreviation: Nat Commun
publication name: Nature communications
language: eng
has national library of medicine journal id: 101528555
derived from: NLM
pg: 4614
has place of publication: England
has primary subject term: D004268Q000378Q000235
has primary subject term: D059630Q000378Q000166
has primary subject term: D012097Q000378Q000235
has primary subject term: D014157Q000378Q000235
has subject term: D000818
has subject term: D051379
has subject term: D028341Q000378
has subject term: D049109
has subject term: D015398
has subject term: D025521Q000378Q000235
has subject term: http://id.nlm.nih.gov/mesh/D000071676
source: Nat Commun. 2024-05-30;15(1):4614.
volume: 15

TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs.
pmid: 38828688
abstract: The factors driving glioma progression remain poorly understood. Here, the epigenetic regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 overexpression promotes HRasV12 anaplastic astrocytoma (AA) progression into epithelioid GBM (Ep-GBM)-like tumors. Co-transfection of TRIM24 with HRasV12 also induces Ep-GBM-like transformation of human neural stem cells (hNSCs) with tumor protein p53 gene (TP53) knockdown. Furthermore, TRIM24 is highly expressed in clinical Ep-GBM specimens. Using single-cell RNA-sequencing (scRNA-Seq), the authors show that TRIM24 overexpression impacts both intratumoral heterogeneity and the tumor microenvironment. Mechanically, HRasV12 activates phosphorylated adaptor for RNA export (PHAX) and upregulates U3 small nucleolar RNAs (U3 snoRNAs) to recruit Ku-dependent DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Overexpressed TRIM24 is also recruited by PHAX to U3 snoRNAs, thereby facilitating DNA-PKcs phosphorylation of TRIM24 at S767/768 residues. Phosphorylated TRIM24 induces epigenome and transcription factor network reprogramming and promotes Ep-GBM-like transformation. Targeting DNA-PKcs with the small molecule inhibitor NU7441 synergizes with temozolomide to reduce Ep-GBM tumorigenicity and prolong animal survival. These findings provide new insights into the epigenetic regulation of Ep-GBM-like transformation and suggest a potential therapeutic strategy for patients with Ep-GBM.
rights: © 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
doi: 10.1002/advs.202400023
creator: OrderedList
  length: 11
  slot:
    index: 1
    item: Xu C
      type: Person
      first name: Chenxin
      last name: Xu
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  slot:
    index: 2
    item: Chen G
      type: Person
      first name: Guoyu
      last name: Chen
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  slot:
    index: 3
    item: Yu B
      type: Person
      first name: Bo
      last name: Yu
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  slot:
    index: 4
    item: Sun B
      type: Person
      first name: Bowen
      last name: Sun
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  slot:
    index: 5
    item: Zhang Y
      type: Person
      first name: Yingwen
      last name: Zhang
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  slot:
    index: 6
    item: Zhang M
      type: Person
      first name: Mingda
      last name: Zhang
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
  slot:
    index: 7
    item: Yang Y
      type: Person
      first name: Yi
      last name: Yang
      member of: Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, 200127, China.
  slot:
    index: 8
    item: Xiao Y
      type: Person
      first name: Yichuan
      last name: Xiao
      member of: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
  slot:
    index: 9
    item: Cheng SY
      type: Person
      first name: Shi-Yuan
      last name: Cheng
      member of: Department of Neurology, Lou and Jean Malnati Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Simpson Querrey Institute for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
  slot:
    index: 10
    item: Li Y
      type: Person
      first name: Yanxin
      last name: Li
      member of: Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, 200127, China.
  slot:
    index: 11
    item: Feng H
      type: Person
      first name: Haizhong
      last name: Feng
      member of: State Key Laboratory of Systems Medicine for Cancer, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
created: 2024-6-3T06:42
date last updated: 2025-01-20
issued: 2024-08
dp: 2024 Aug
created: 2024-6-3T05:53
e ISSN: 2198-3844
has issn l: 2198-3844
issue: 29
has NLM journal title abbreviation: Adv Sci (Weinh)
publication name: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
language: eng
has national library of medicine journal id: 101664569
derived from: NLM
pg: e2400023
has place of publication: Germany
has primary subject term: D018450
has primary subject term: D005910Q000235Q000378Q000473
has primary subject term: D009154Q000235
has primary subject term: D020537Q000235Q000378
has subject term: D000818
has subject term: D006801
has subject term: D051379
has subject term: D001932Q000235Q000378Q000473
has subject term: D002352
has subject term: D045744
has subject term: D004195
has subject term: D051747Q000235Q000378
has subject term: D009687Q000235Q000378
has subject term: D018631Q000378Q000235
source: Adv Sci (Weinh). 2024-08;11(29):e2400023.
volume: 11

Ameloblastin and its multifunctionality in amelogenesis: A review.
pmid: 38815936
abstract: Extracellular matrix proteins play crucial roles in the formation of mineralized tissues like bone and teeth via multifunctional mechanisms. In tooth enamel, ameloblastin (Ambn) is one such multifunctional extracellular matrix protein implicated in cell signaling and polarity, cell adhesion to the developing enamel matrix, and stabilization of prismatic enamel morphology. To provide a perspective for Ambn structure and function, we begin this review by describing dental enamel and enamel formation (amelogenesis) followed by a description of enamel extracellular matrix. We then summarize the established domains and motifs in Ambn protein, human amelogenesis imperfecta cases, and genetically engineered mouse models involving mutated or null Ambn. We subsequently delineate in silico, in vitro, and in vivo evidence for the amphipathic helix in Ambn as a proposed cell-matrix adhesive and then more recent in vitro evidence for the multitargeting domain as the basis for dynamic interactions of Ambn with itself, amelogenin, and membranes. The multitargeting domain facilitates tuning between Ambn-membrane interactions and self/co-assembly and supports a likely overall role for Ambn as a matricellular protein. We anticipate that this review will enhance the understanding of multifunctional matrix proteins by consolidating diverse mechanisms through which Ambn contributes to enamel extracellular matrix mineralization.
rights: Copyright © 2024. Published by Elsevier B.V.
has PII: S0945-053X(24)00068-4
doi: 10.1016/j.matbio.2024.05.007
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Kegulian NC
      type: Person
      first name: Natalie C
      last name: Kegulian
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St., CSA 148, Los Angeles, CA 90033, USA.
  slot:
    index: 2
    item: Visakan G
      type: Person
      first name: Gayathri
      last name: Visakan
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St., CSA 148, Los Angeles, CA 90033, USA.
  slot:
    index: 3
    item: Bapat RA
      type: Person
      first name: Rucha Arun
      last name: Bapat
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St., CSA 148, Los Angeles, CA 90033, USA.
  slot:
    index: 4
    item: Moradian-Oldak J
      type: Person
      first name: Janet
      last name: Moradian-Oldak
      member of: Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar St., CSA 148, Los Angeles, CA 90033, USA. Electronic address: joldak@usc.edu.
created: 2024-5-31T00:42
date last updated: 2025-01-20
issued: 2024-08
dp: 2024 Aug
created: 2024-5-30T19:24
e ISSN: 1569-1802
has issn l: 0945-053X
has NLM journal title abbreviation: Matrix Biol
publication name: Matrix biology : journal of the International Society for Matrix Biology
language: eng
has national library of medicine journal id: 9432592
derived from: NLM
starting page: 62
ending page: 76
has place of publication: Netherlands
has primary subject term: D003746Q000378Q000235
has primary subject term: D000566Q000235
has primary subject term: D000567Q000235Q000378Q000473
has primary subject term: D003743Q000378Q000737
has primary subject term: D005109Q000378
has subject term: D006801
has subject term: D000818
has subject term: D051379
has subject term: D053523Q000378Q000235Q000737
has subject term: D002448
source: Matrix Biol. 2024-08;131():62-76.
volume: 131

Ivonescimab Plus Chemotherapy in Non-Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial.
pmid: 38820549
abstract: For patients with non-small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited.To compare the efficacy of ivonescimab plus chemotherapy with chemotherapy alone for patients with relapsed advanced or metastatic non-small cell lung cancer with the epidermal growth factor receptor (EGFR) variant.Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China enrolled participants from January 2022 to November 2022; a total of 322 eligible patients were enrolled.Participants received ivonescimab (n = 161) or placebo (n = 161) plus pemetrexed and carboplatin once every 3 weeks for 4 cycles, followed by maintenance therapy of ivonescimab plus pemetrexed or placebo plus pemetrexed.The primary end point was progression-free survival in the intention-to-treat population assessed by an independent radiographic review committee (IRRC) per Response Evaluation Criteria in Solid Tumors version 1.1. The results of the first planned interim analysis are reported.Among 322 enrolled patients in the ivonescimab and placebo groups, the median age was 59.6 vs 59.4 years and 52.2% vs 50.9% of patients were female. As of March 10, 2023, median follow-up time was 7.89 months. Median progression-free survival was 7.1 (95% CI, 5.9-8.7) months in the ivonescimab group vs 4.8 (95% CI, 4.2-5.6) months for placebo (difference, 2.3 months; hazard ratio [HR], 0.46 [95% CI, 0.34-0.62]; P < .001). The prespecified subgroup analysis showed progression-free survival benefit favoring patients receiving ivonescimab over placebo across almost all subgroups, including patients whose disease progressed while receiving third-generation EGFR-TKI therapy (HR, 0.48 [95% CI 0.35-0.66]) and those with brain metastases (HR, 0.40 [95% CI, 0.22-0.73]). The objective response rate was 50.6% (95% CI, 42.6%-58.6%) with ivonescimab and 35.4% (95% CI, 28.0%-43.3%) with p[cell cut: 2857 characters, first 2000 kept]
has PII: 2819600
doi: 10.1001/jama.2024.10613
creator: OrderedList
  length: 69
  slot:
    index: 1
    item: Fang W
      type: Person
      first name: Wenfeng
      last name: Fang
      member of: Sun Yat-sen University Cancer Center, Guangzhou, China.
  slot:
    index: 2
    item: Zhao Y
      type: Person
      first name: Yuanyuan
      last name: Zhao
      member of: Sun Yat-sen University Cancer Center, Guangzhou, China.
  slot:
    index: 3
    item: Luo Y
      type: Person
      first name: Yongzhong
      last name: Luo
      member of: Hunan Cancer Hospital, Changsha, China.
  slot:
    index: 4
    item: Yang R
      type: Person
      first name: Runxiang
      last name: Yang
      member of: Yunnan Cancer Hospital, Kunming, China.
  slot:
    index: 5
    item: Huang Y
      type: Person
      first name: Yan
      last name: Huang
      member of: Sun Yat-sen University Cancer Center, Guangzhou, China.
  slot:
    index: 6
    item: He Z
      type: Person
      first name: Zhiyong
      last name: He
      member of: Fujian Provincial Tumor Hospital, Fuzhou, China.
  slot:
    index: 7
    item: Zhao H
      type: Person
      first name: Hui
      last name: Zhao
      member of: The Second Hospital of Anhui Medical University, Hefei, China.
  slot:
    index: 8
    item: Li M
      type: Person
      first name: Mingjun
      last name: Li
      member of: The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  slot:
    index: 9
    item: Li K
      type: Person
      first name: Kai
      last name: Li
      member of: Tianjin Medical University Cancer Institute & Hospital, Tianjin, China.
  slot:
    index: 10
    item: Song Q
      type: Person
      first name: Qibing
      last name: Song
      member of: Renmin Hospital of Wuhan University, Wuhan, China.
  slot:
    index: 11
    item: Du X
      type: Person
      first name: Xiaobo
      last name: Du
      member of: Mianyang Central Hospital, Mianyang, China.
  slot:
    index: 12
    item: Sun Y
      type: Person
      first name: Yulan
      last name: Sun
      member of: Shandong Cancer Prevention and Treatment Institute, Jinan, China.
  slot:
    index: 13
    item: Li W
      type: Person
      first name: Wei
      last name: Li
      member of: The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
  slot:
    index: 14
    item: Xu F
      type: Person
      first name: Fei
      last name: Xu
      member of: The First Affiliated Hospital of Nanchang University, Nanchang, China.
  slot:
    index: 15
    item: Wang Z
      type: Person
      first name: Zhiyu
      last name: Wang
      member of: The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  slot:
    index: 16
    item: Yang K
      type: Person
      first name: Kunning
      last name: Yang
      member of: Weifang No. 2 People's Hospital, Weifang, China.
  slot:
    index: 17
    item: Fan Y
      type: Person
      first name: Yun
      last name: Fan
      member of: Zhejiang Cancer Hospital, Hangzhou, China.
  slot:
    index: 18
    item: Liu B
      type: Person
      first name: Baogang
      last name: Liu
      member of: Harbin Medical University Cancer Hospital, Harbin, China.
  slot:
    index: 19
    item: Zhao H
      type: Person
      first name: Hongyun
      last name: Zhao
      member of: Sun Yat-sen University Cancer Center, Guangzhou, China.
  slot:
    index: 20
    item: Hu Y
      type: Person
      first name: Ying
      last name: Hu
      member of: Beijing Chest Hospital, Capital Medical University, Beijing, China.
  slot:
    index: 21
    item: Jia L
      type: Person
      first name: Li
      last name: Jia
      member of: Yuncheng Central Hospital of Shanxi Province, Yuncheng, China.
  slot:
    index: 22
    item: Xu S
      type: Person
      first name: Shen
      last name: Xu
      member of: Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou, China.
  slot:
    index: 23
    item: Yi T
      type: Person
      first name: Tienan
      last name: Yi
      member of: Xiangyang Central Hospital, Xiangyang, China.
  slot:
    index: 24
    item: Lv D
      type: Person
      first name: Dongqing
      last name: Lv
      member of: Taizhou Municipal Hospital, Taizhou, China.
  slot:
    index: 25
    item: Lan H
      type: Person
      first name: Haitao
      last name: Lan
      member of: Sichuan Provincial People's Hospital, Chengdu, China.
  slot:
    index: 26
    item: Li M
      type: Person
      first name: Mengxia
      last name: Li
      member of: Army Medical Center of Chinese People's Liberation Army, Chongqing, China.
  slot:
    index: 27
    item: Liang W
      type: Person
      first name: Wenhua
      last name: Liang
      member of: The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  slot:
    index: 28
    item: Wang Y
      type: Person
      first name: Yongsheng
      last name: Wang
      member of: West China Hospital of Sichuan University, Chengdu, China.
creator: HARMONi-A Study Investigators
created: 2024-5-31T18:42
date last updated: 2025-01-20
issued: 2024-08-20
dp: 2024 08 20
created: 2024-5-31T16:32
e ISSN: 1538-3598
has issn l: 0098-7484
issue: 7
has NLM journal title abbreviation: JAMA
publication name: JAMA
language: eng
has national library of medicine journal id: 7501160
derived from: NLM
starting page: 561
ending page: 570
has place of publication: United States
has primary subject term: D000971Q000008Q000009
has primary subject term: D016190Q000008Q000009
has primary subject term: D002289Q000188Q000235Q000401
has primary subject term: D066246Q000235
has primary subject term: D008175Q000188Q000235Q000401
has primary subject term: D000068437Q000008Q000009
has primary subject term: http://id.nlm.nih.gov/mesh/D000077982
has subject term: D000328
has subject term: D000368
has subject term: D005260
has subject term: D006801
has subject term: D008297
has subject term: D008875
has subject term: D061067Q000008Q000009
has subject term: D004311
has subject term: D057194
has subject term: D009154
has subject term: D018033Q000008Q000009
source: JAMA. 2024-08-20;332(7):561-570.
volume: 332

Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
pmid: 38853519
abstract: Metabolic dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), in which the abnormalities in brown adipose tissue (BAT) play important roles. However, the cellular composition and function of BAT as well as its pathological significance in diabetes remain incompletely understood. Our objective is to delineate the single-cell landscape of BAT-derived stromal vascular fraction (SVF) and their characteristic alterations in T2DM rats.T2DM was induced in rats by intraperitoneal injection of low-dose streptozotocin and high-fat diet feeding. Single-cell mRNA sequencing was then performed on BAT samples and compared to normal rats to characterize changes in T2DM rats. Subsequently, the importance of key cell subsets in T2DM was elucidated using various functional studies.Almost all cell types in the BAT-derived SVF of T2DM rats exhibited enhanced inflammatory responses, increased angiogenesis, and disordered glucose and lipid metabolism. The multidirectional differentiation potential of adipose tissue-derived stem cells was also reduced. Moreover, macrophages played a pivotal role in intercellular crosstalk of BAT-derived SVF. A novel Rarres2+macrophage subset promoted the differentiation and metabolic function of brown adipocytes via adipose-immune crosstalk.BAT SVF exhibited strong heterogeneity in cellular composition and function and contributed to T2DM as a significant inflammation source, in which a novel macrophage subset was identified that can promote brown adipocyte function.
has PII: dmj.2023.0278
doi: 10.4093/dmj.2023.0278
creator: OrderedList
  length: 10
  slot:
    index: 1
    item: Gu J
      type: Person
      first name: Junfei
      last name: Gu
      member of: Department of Endocrinology & Geriatrics, Shandong Provincial Hospital, Shandong University, Jinan, China.Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.Department of Endocrinology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, China.
  slot:
    index: 2
    item: Jin J
      type: Person
      first name: Jiajia
      last name: Jin
      member of: National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 3
    item: Ren X
      type: Person
      first name: Xiaoyu
      last name: Ren
      member of: National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 4
    item: Zhang X
      type: Person
      first name: Xinjie
      last name: Zhang
      member of: Department of Biology, University College London, London, UK.
  slot:
    index: 5
    item: Li J
      type: Person
      first name: Jiaxuan
      last name: Li
      member of: Department of Endocrinology & Geriatrics, Shandong Provincial Hospital, Shandong University, Jinan, China.Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 6
    item: Wang X
      type: Person
      first name: Xiaowei
      last name: Wang
      member of: National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 7
    item: Zhang S
      type: Person
      first name: Shucui
      last name: Zhang
      member of: National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 8
    item: Yin X
      type: Person
      first name: Xianlun
      last name: Yin
      member of: National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 9
    item: Zhang Q
      type: Person
      first name: Qunye
      last name: Zhang
      member of: National Key Laboratory for Innovation and Transformation of Luobing Theory, Shandong University, Jinan, China.Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Shandong University, Jinan, China.Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
  slot:
    index: 10
    item: Wang Z
      type: Person
      first name: Zhe
      last name: Wang
      member of: Department of Endocrinology & Geriatrics, Shandong Provincial Hospital, Shandong University, Jinan, China.Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
created: 2024-6-10T06:42
date last updated: 2025-01-20
issued: 2024-09
dp: 2024 Sep
created: 2024-6-10T02:59
e ISSN: 2233-6087
has issn l: 2233-6079
issue: 5
has NLM journal title abbreviation: Diabetes Metab J
publication name: Diabetes & metabolism journal
language: eng
has national library of medicine journal id: 101556588
derived from: NLM
starting page: 885
ending page: 900
has place of publication: Korea (South)
has primary subject term: D003921
has primary subject term: D008264Q000378
has primary subject term: D003924Q000378
has primary subject term: D002001Q000378
has primary subject term: D052437Q000378
has primary subject term: D059010
has subject term: D000818
has subject term: D051381
has subject term: D008297
has subject term: D059305
has subject term: D002454
has subject term: D017207
source: Diabetes Metab J. 2024-09;48(5):885-900.
volume: 48

Universal Formation of Single Atoms from Molten Salt for Facilitating Selective CO2 Reduction.
pmid: 38857899
abstract: Clarifying the formation mechanism of single-atom sites guides the design of emerging single-atom catalysts (SACs) and facilitates the identification of the active sites at atomic scale. Herein, a molten-salt atomization strategy is developed for synthesizing zinc (Zn) SACs with temperature universality from 400 to 1000/1100 °C and an evolved coordination from Zn-N2Cl2 to Zn-N4. The electrochemical tests and in situ attenuated total reflectance-surface-enhanced infrared absorption spectroscopy confirm that the Zn-N4 atomic sites are active for electrochemical carbon dioxide (CO2) conversion to carbon monoxide (CO). In a strongly acidic medium (0.2 m K2SO4, pH = 1), the Zn SAC formed at 1000 °C (Zn1NC) containing Zn-N4 sites enables highly selective CO2 electroreduction to CO, with nearly 100% selectivity toward CO product in a wide current density range of 100-600 mA cm-2. During a 50 h continuous electrolysis at the industrial current density of 200 mA cm-2, Zn1NC achieves Faradaic efficiencies greater than 95% for CO product. The work presents a temperature-universal formation of single-atom sites, which provides a novel platform for unraveling the active sites in Zn SACs for CO2 electroreduction and extends the synthesis of SACs with controllable coordination sites.
rights: © 2024 Wiley‐VCH GmbH.
doi: 10.1002/adma.202406380
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Hao Q
      type: Person
      first name: Qi
      last name: Hao
      member of: School of Materials Science & Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China.School of Engineering, Westlake University, Hangzhou, Zhejiang, 310030, China.
  slot:
    index: 2
    item: Zhen C
      type: Person
      first name: Cheng
      last name: Zhen
      member of: Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang, 315200, China.
  slot:
    index: 3
    item: Tang Q
      type: Person
      first name: Qi
      last name: Tang
      member of: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
  slot:
    index: 4
    item: Wang J
      type: Person
      first name: Jiazhi
      last name: Wang
      member of: Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, 230026, China.
  slot:
    index: 5
    item: Ma P
      type: Person
      first name: Peiyu
      last name: Ma
      member of: Key Laboratory of Precision and Intelligent Chemistry, National Synchrotron Radiation Laboratory, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), University of Science and Technology of China, Hefei, Anhui, 230026, China.
  slot:
    index: 6
    item: Wu J
      type: Person
      first name: Junxiu
      last name: Wu
      member of: College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
  slot:
    index: 7
    item: Wang T
      type: Person
      first name: Tianyang
      last name: Wang
      member of: School of Engineering, Westlake University, Hangzhou, Zhejiang, 310030, China.
  slot:
    index: 8
    item: Liu D
      type: Person
      first name: Dongxue
      last name: Liu
      member of: Key Laboratory of Automobile Materials Ministry of Education and College of Materials Science and Engineering, Jilin University, Changchun, Jilin, 130022, China.
  slot:
    index: 9
    item: Xie L
      type: Person
      first name: Linxuan
      last name: Xie
      member of: School of Engineering, Westlake University, Hangzhou, Zhejiang, 310030, China.
  slot:
    index: 10
    item: Liu X
      type: Person
      first name: Xiao
      last name: Liu
      member of: School of Engineering, Westlake University, Hangzhou, Zhejiang, 310030, China.
  slot:
    index: 11
    item: Gu MD
      type: Person
      first name: M Danny
      last name: Gu
      member of: Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang, 315200, China.
  slot:
    index: 12
    item: Hoffmann MR
      type: Person
      first name: Michael R
      last name: Hoffmann
      member of: Department of Environmental Science and Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, CA, 91125, USA.
  slot:
    index: 13
    item: Yu G
      type: Person
      first name: Gang
      last name: Yu
      member of: Merging Contaminants Research Center, Beijing Normal University, Zhuhai, Guangdong, 519087, China.
  slot:
    index: 14
    item: Liu K
      type: Person
      first name: Kai
      last name: Liu
      member of: School of Engineering, Westlake University, Hangzhou, Zhejiang, 310030, China.
  slot:
    index: 15
    item: Lu J
      type: Person
      first name: Jun
      last name: Lu
      member of: College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
created: 2024-6-11T00:42
date last updated: 2025-01-19
issued: 2024-08
dp: 2024 Aug
created: 2024-6-10T20:03
e ISSN: 1521-4095
has issn l: 0935-9648
issue: 33
has NLM journal title abbreviation: Adv Mater
publication name: Advanced materials (Deerfield Beach, Fla.)
language: eng
has national library of medicine journal id: 9885358
derived from: NLM
pg: e2406380
has place of publication: Germany
source: Adv Mater. 2024-08;36(33):e2406380.
volume: 36

Circulating Tumor DNA-Guided De-Escalation Targeted Therapy for Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial.
pmid: 38869865
abstract: Uninterrupted targeted therapy until disease progression or intolerable toxic effects is currently the routine therapy for advanced non-small cell lung cancer (NSCLC) involving driver gene variations. However, drug resistance is inevitable.To assess the clinical feasibility of adaptive de-escalation tyrosine kinase inhibitor (TKI) treatment guided by circulating tumor DNA (ctDNA) for achieving complete remission after local consolidative therapy (LCT) in patients with advanced NSCLC.This prospective nonrandomized controlled trial was conducted at a single center from June 3, 2020, to July 19, 2022, and included 60 patients with advanced NSCLC with driver variations without radiologically detectable disease after TKI and LCT. The median (range) follow-up time was 19.2 (3.8-29.7) months. Data analysis was conducted from December 15, 2022, to May 10, 2023.Cessation of TKI treatment and follow-up every 3 months. Treatment was restarted in patients with progressive disease (defined by the Response Evaluation Criteria in Solid Tumors 1.1 criteria), detectable ctDNA, or elevated carcinoembryonic antigen (CEA) levels, whichever manifested first, and treatment ceased if all indicators were negative during follow-up surveillance.Progression-free survival (PFS). Secondary end points were objective response rate, time to next treatment, and overall survival.Among the total study sample of 60 participants (median [range] age, 55 [21-75] years; 33 [55%] were female), the median PFS was 18.4 (95% CI, 12.6-24.2) months and the median (range) total treatment break duration was 9.1 (1.5-28.1) months. Fourteen patients (group A) remained in TKI cessation with a median (range) treatment break duration of 20.3 (6.8-28.1) months; 31 patients (group B) received retreatment owing to detectable ctDNA and/or CEA and had a median PFS of 20.2 (95% CI, 12.9-27.4) months with a median (range) total treatment break duration of 8.8 (1.5-20.6) months; and 15 patients (group C) who underwent retreat[cell cut: 2647 characters, first 2000 kept]
has PII: 2820083
doi: 10.1001/jamaoncol.2024.1779
creator: OrderedList
  length: 29
  slot:
    index: 1
    item: Dong S
      type: Person
      first name: Song
      last name: Dong
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 2
    item: Wang Z
      type: Person
      first name: Zhen
      last name: Wang
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 3
    item: Zhang JT
      type: Person
      first name: Jia-Tao
      last name: Zhang
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 4
    item: Yan B
      type: Person
      first name: Bingfa
      last name: Yan
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 5
    item: Zhang C
      type: Person
      first name: Chao
      last name: Zhang
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 6
    item: Gao X
      type: Person
      first name: Xuan
      last name: Gao
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 7
    item: Sun H
      type: Person
      first name: Hao
      last name: Sun
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 8
    item: Li YS
      type: Person
      first name: Yang-Si
      last name: Li
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 9
    item: Yan HH
      type: Person
      first name: Hong-Hong
      last name: Yan
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 10
    item: Tu HY
      type: Person
      first name: Hai-Yan
      last name: Tu
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 11
    item: Liu SM
      type: Person
      first name: Si-Yang Maggie
      last name: Liu
      member of: Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.Chinese Thoracic Oncology Group, Guangzhou, Guangdong, China.
  slot:
    index: 12
    item: Gong Y
      type: Person
      first name: Yuhua
      last name: Gong
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 13
    item: Gao W
      type: Person
      first name: Wei
      last name: Gao
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 14
    item: Huang J
      type: Person
      first name: Jie
      last name: Huang
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 15
    item: Liao RQ
      type: Person
      first name: Ri-Qiang
      last name: Liao
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 16
    item: Lin JT
      type: Person
      first name: Jun-Tao
      last name: Lin
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 17
    item: Ke EE
      type: Person
      first name: E-E
      last name: Ke
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 18
    item: Xu Z
      type: Person
      first name: Zelong
      last name: Xu
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 19
    item: Zhang X
      type: Person
      first name: Xue
      last name: Zhang
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 20
    item: Xia X
      type: Person
      first name: Xuefeng
      last name: Xia
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 21
    item: Li AN
      type: Person
      first name: An-Na
      last name: Li
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 22
    item: Liu SY
      type: Person
      first name: Si-Yang
      last name: Liu
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 23
    item: Pan Y
      type: Person
      first name: Yi
      last name: Pan
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 24
    item: Yang JJ
      type: Person
      first name: Jin-Ji
      last name: Yang
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 25
    item: Zhong WZ
      type: Person
      first name: Wen-Zhao
      last name: Zhong
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  slot:
    index: 26
    item: Yi X
      type: Person
      first name: Xin
      last name: Yi
      member of: Geneplus-Beijing Institute, Beijing, China.
  slot:
    index: 27
    item: Zhou Q
      type: Person
      first name: Qing
      last name: Zhou
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.Chinese Thoracic Oncology Group, Guangzhou, Guangdong, China.
  slot:
    index: 28
    item: Yang XN
      type: Person
      first name: Xue-Ning
      last name: Yang
      member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
created: 2024-6-13T12:43
date last updated: 2025-01-20
issued: 2024-07-01
dp: 2024 Jul 01
created: 2024-6-13T11:34
e ISSN: 2374-2445
has issn l: 2374-2437
issue: 7
has NLM journal title abbreviation: JAMA Oncol
publication name: JAMA oncology
language: eng
has national library of medicine journal id: 101652861
derived from: NLM
starting page: 932
ending page: 940
has place of publication: United States
has primary subject term: D002289Q000188Q000235Q000473
has primary subject term: D000074141Q000097Q000235
has primary subject term: D008175Q000188Q000235Q000473
has primary subject term: D047428Q000627Q000008
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D008875
has subject term: D000368
has subject term: D000328
has subject term: D011446
has subject term: D058990Q000379
source: JAMA Oncol. 2024-07-01;10(7):932-940.
volume: 10

Alternative splicing drives the functional diversification of a bHLH transcription factor in the control of growth and drought tolerance in rice.
pmid: 38880686
has PII: S2095-9273(24)00397-9
doi: 10.1016/j.scib.2024.06.001
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Ning M
      type: Person
      first name: Min
      last name: Ning
      member of: Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs, School of Agriculture, Yunnan University, Kunming 650091, China.
  slot:
    index: 2
    item: Li Q
      type: Person
      first name: Qinyan
      last name: Li
      member of: Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs, School of Agriculture, Yunnan University, Kunming 650091, China.
  slot:
    index: 3
    item: Wang Y
      type: Person
      first name: Ya
      last name: Wang
      member of: Cereal Crops Research Institute, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
  slot:
    index: 4
    item: Li Q
      type: Person
      first name: Qingmao
      last name: Li
      member of: Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs, School of Agriculture, Yunnan University, Kunming 650091, China.
  slot:
    index: 5
    item: Tao Y
      type: Person
      first name: Yonghong
      last name: Tao
      member of: Wenshan Academy of Agricultural Sciences, Wenshan 663000, China.
  slot:
    index: 6
    item: Zhang F
      type: Person
      first name: Fan
      last name: Zhang
      member of: State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100081, China. Electronic address: zhangfan03@caas.cn.
  slot:
    index: 7
    item: Hu F
      type: Person
      first name: Fengyi
      last name: Hu
      member of: Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs, School of Agriculture, Yunnan University, Kunming 650091, China. Electronic address: hfengyi@ynu.edu.cn.
  slot:
    index: 8
    item: Huang L
      type: Person
      first name: Liyu
      last name: Huang
      member of: Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs, School of Agriculture, Yunnan University, Kunming 650091, China. Electronic address: lyhuang@ynu.edu.cn.
created: 2024-6-17T00:42
date last updated: 2025-01-19
issued: 2025-01-30
dp: 2025 Jan 30
created: 2024-6-16T21:55
e ISSN: 2095-9281
has issn l: 2095-9273
issue: 2
has NLM journal title abbreviation: Sci Bull (Beijing)
publication name: Science bulletin
language: eng
has national library of medicine journal id: 101655530
derived from: NLM
starting page: 153
ending page: 156
has place of publication: Netherlands
source: Sci Bull (Beijing). 2025-01-30;70(2):153-156.
volume: 70

Preparation and characterization of CS/PAT/ MWCNT@MgAl-LDHs nanocomposite for Cd2+ removal and 4-nitrophenol reduction.
pmid: 38887760
abstract: The present study evaluated the performance of multiwalled carbon nanotube (MWCNT)@MgAl-layered double hydroxide (LDH) nanoparticles loaded on poly-2 aminothiazole (PAT)/chitosan (CS) matrix (CPML) to remove Cd2+ ions from aqueous solution. The removal efficiency of modified CS/PAT with MWCNT@MgAl-LDHs was increased significantly compared to pure CS/PAT. The influence of heavy metal ion concentration, pH, temperature, adsorbent dosage, and contact time on the adsorption was examined. The optimum conditions for the adsorption of Cd2+ ions were 25 0C with the adsorbent dosage of 0.06 g and initial concentration for adsorption of the Cd2+ 100 mg/L at pH = 8. The maximum adsorption capacity was measured to be 1106.19 mg/g. The values of thermodynamic parameters namely Gibbs free energy (ΔG°), entropy change (ΔS°), and enthalpy change (ΔH°) indicated the feasibility, spontaneity and the endothermic nature of the adsorption process, respectively. The pseudo-second-order kinetics and the Langmuir model were selected as the best models for the adsorption process. Also, CPML nanocomposite (NC) was successfully tested for p-nitrophenol (p-NP) reduction in the presence of NaBH4. The reaction was nearly completed in 6 min. The fabricated CPML-NC could be reused for three consecutive cycles.
rights: © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 885
doi: 10.1007/s40201-023-00885-8
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Rostami MS
      type: Person
      first name: Mohammad Saeid
      last name: Rostami
      member of: Department of Organic Chemistry, Razi University, Kermanshah, 67149-67346 Iran.
  slot:
    index: 2
    item: Khodaei MM
      type: Person
      first name: Mohammad Mehdi
      last name: Khodaei
      member of: Department of Organic Chemistry, Razi University, Kermanshah, 67149-67346 Iran.Nanoscience and Nanotechnology Research Center, Razi University, Kermanshah, 67149-67346 Iran.
created: 2024-6-18T06:41
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-6-18T04:02
ISSN: 2052-336X
issue: 1
has NLM journal title abbreviation: J Environ Health Sci Eng
publication name: Journal of environmental health science & engineering
language: eng
has national library of medicine journal id: 101613643
derived from: NLM
starting page: 179
ending page: 195
has place of publication: England
source: J Environ Health Sci Eng. 2024-06;22(1):179-195.
volume: 22

Triblock Glycopolymers with Two 10-mer Blocks of Activating Sugars Enhance the Activation of Acrosomal Exocytosis in Mouse Sperm.
pmid: 38911911
abstract: Carbohydrate recognition is imperative for the induction of sperm acrosomal exocytosis (AE), an essential phenomenon in mammalian fertilization. In mouse sperm, polynorbornene 100-mers displaying fucose or mannose moieties were effective at inducing AE. In contrast, glycopolymers exhibiting glucose sugars resulted in no AE activation. To further elucidate the role of ligand density on the activation of AE in mouse sperm, a triple-stain flow cytometry assay was employed to determine the efficacy of polynorbornene block copolymers with barbell-like sequences as initiators of AE. Triblock (ABA or ABC) copolymers were synthesized by ring-opening metathesis polymerization (ROMP) with one or two activating sugars, mannose or fucose, and one nonactivating sugar, glucose. The active ligand fractions in the polymers varied from 10, 20, or 40%. Simultaneously, random copolymers comprising 20% activating ligands were prepared to confirm the importance of ligand positionality in AE activation in mouse sperm. Polynorbornene 100-mers possessing two 10-mer blocks of activating sugars were the most effective copolymers at inducing AE with levels of AE comparable to their homopolymer counterparts and more effective than their random analogues. Small-angle X-ray scattering (SAXS) was then performed to verify that there were no differences in the conformations of the glycopolymers contributing to their varying AE activity. SAXS data analysis confirmed that all of the glycopolymers assumed semiflexible cylindrical structures with similar radii and Kuhn lengths. These findings suggest that the overall ligand density of the sugar moieties in the polymer is less important than the positionality of short blocks of high-density ligands for AE activation in mouse sperm.
rights: © 2024 The Authors. Published by American Chemical Society.
doi: 10.1021/acsbiomedchemau.4c00012
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Mendez LC
      type: Person
      first name: Luz C
      last name: Mendez
      member of: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
  slot:
    index: 2
    item: Kennedy M
      type: Person
      first name: Mitchell
      last name: Kennedy
      member of: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
  slot:
    index: 3
    item: Bhatia SR
      type: Person
      first name: Surita R
      last name: Bhatia
      member of: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
  slot:
    index: 4
    item: Sampson NS
      type: Person
      first name: Nicole S
      last name: Sampson
      member of: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, United States.
created: 2024-6-24T06:41
date last updated: 2025-01-20
issued: 2024-06-19
dp: 2024 Jun 19
created: 2024-6-24T05:31
e ISSN: 2694-2437
has issn l: 2694-2437
issue: 3
has NLM journal title abbreviation: ACS Bio Med Chem Au
publication name: ACS bio & med chem Au
language: eng
has national library of medicine journal id: 9918232604406676
derived from: NLM
starting page: 165
ending page: 177
has place of publication: United States
source: ACS Bio Med Chem Au. 2024-06-19;4(3):165-177.
volume: 4

Acrylamide drives amidase-mediated gut dysbiosis to aggravate colitis.
pmid: 38909004
has PII: S2095-9273(24)00400-6
doi: 10.1016/j.scib.2024.06.004
creator: OrderedList
  length: 18
  slot:
    index: 1
    item: Li D
      type: Person
      first name: Daotong
      last name: Li
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 2
    item: Luo Y
      type: Person
      first name: Yinghua
      last name: Luo
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 3
    item: Fan H
      type: Person
      first name: Huimin
      last name: Fan
      member of: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
  slot:
    index: 4
    item: Dong L
      type: Person
      first name: Li
      last name: Dong
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 5
    item: Zhang X
      type: Person
      first name: Xiaoying
      last name: Zhang
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 6
    item: Feng Y
      type: Person
      first name: Yu
      last name: Feng
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 7
    item: Tian M
      type: Person
      first name: Meiling
      last name: Tian
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 8
    item: Zhang S
      type: Person
      first name: Shuqing
      last name: Zhang
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 9
    item: Chen W
      type: Person
      first name: Wenjing
      last name: Chen
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 10
    item: Zhang L
      type: Person
      first name: Lujia
      last name: Zhang
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 11
    item: Gao J
      type: Person
      first name: Jianwei
      last name: Gao
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 12
    item: Ma X
      type: Person
      first name: Xiangning
      last name: Ma
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 13
    item: Wang X
      type: Person
      first name: Xiaofei
      last name: Wang
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 14
    item: Ma C
      type: Person
      first name: Chen
      last name: Ma
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 15
    item: Zheng R
      type: Person
      first name: Ruimao
      last name: Zheng
      member of: Department of Anatomy, Histology and Embryology, Health Science Center, Peking University, Beijing 100191, China.
  slot:
    index: 16
    item: Hu X
      type: Person
      first name: Xiaosong
      last name: Hu
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
  slot:
    index: 17
    item: Wang J
      type: Person
      first name: Jinfeng
      last name: Wang
      member of: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address: wangjf@cau.edu.cn.
  slot:
    index: 18
    item: Chen F
      type: Person
      first name: Fang
      last name: Chen
      member of: College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture, Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China. Electronic address: chenfangch@sina.com.
created: 2024-6-23T00:42
date last updated: 2025-01-19
issued: 2025-01-30
dp: 2025 Jan 30
created: 2024-6-22T21:58
e ISSN: 2095-9281
has issn l: 2095-9273
issue: 2
has NLM journal title abbreviation: Sci Bull (Beijing)
publication name: Science bulletin
language: eng
has national library of medicine journal id: 101655530
derived from: NLM
starting page: 157
ending page: 161
has place of publication: Netherlands
source: Sci Bull (Beijing). 2025-01-30;70(2):157-161.
volume: 70

Letter to the Editor: Lazzaro responds to Kennedy et al.
pmid: 38916817
has PII: 10.1007/s10198-024-01703-0
doi: 10.1007/s10198-024-01703-0
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Lazzaro C
      type: Person
      first name: Carlo
      last name: Lazzaro
      member of: Health Economist and Research Director, Studio di Economia Sanitaria, Via Stefanardo da Vimercate, 19, Milan, 20128, Italy. carlo.lazzaro@tiscalinet.it.Biology and Biotechnologies Department Lazzaro Spallanzani , University of Pavia, Pavia, 27100, Italy. carlo.lazzaro@tiscalinet.it.
created: 2024-6-25T12:42
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2024-6-25T11:18
e ISSN: 1618-7601
has issn l: 1618-7598
issue: 1
has NLM journal title abbreviation: Eur J Health Econ
publication name: The European journal of health economics : HEPAC : health economics in prevention and care
language: eng
has national library of medicine journal id: 101134867
derived from: NLM
starting page: 141
ending page: 142
has place of publication: Germany
source: Eur J Health Econ. 2025-02;26(1):141-142.
volume: 26

FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development.
pmid: 38910207
abstract: Stem/progenitor cells differentiate into different cell lineages during organ development and morphogenesis. Signaling pathway networks and mechanotransduction are important factors to guide the lineage commitment of stem/progenitor cells during craniofacial tissue morphogenesis. Here, we used tooth root development as a model to explore the roles of FGF signaling and mechanotransduction as well as their interaction in regulating the progenitor cell fate decision. We show that Fgfr1 is expressed in the mesenchymal progenitor cells and their progeny during tooth root development. Loss of Fgfr1 in Gli1+ progenitors leads to hyperproliferation and differentiation, which causes narrowed periodontal ligament (PDL) space with abnormal cementum/bone formation leading to ankylosis. We further show that aberrant activation of WNT signaling and mechanosensitive channel Piezo2 occurs after loss of FGF signaling in Gli1-CreER;Fgfr1fl/fl mice. Overexpression of Piezo2 leads to increased osteoblastic differentiation and decreased Piezo2 leads to downregulation of WNT signaling. Mechanistically, an FGF/PIEZO2/WNT signaling cascade plays a crucial role in modulating the fate of progenitors during root morphogenesis. Downregulation of WNT signaling rescues tooth ankylosis in Fgfr1 mutant mice. Collectively, our findings uncover the mechanism by which FGF signaling regulates the fate decisions of stem/progenitor cells, and the interactions among signaling pathways and mechanotransduction during tooth root development, providing insights for future tooth root regeneration.
rights: © 2024. The Author(s).
has PII: 10.1038/s41413-024-00345-5
doi: 10.1038/s41413-024-00345-5
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Pei F
      type: Person
      first name: Fei
      last name: Pei
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
  slot:
    index: 2
    item: Guo T
      type: Person
      first name: Tingwei
      last name: Guo
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 3
    item: Zhang M
      type: Person
      first name: Mingyi
      last name: Zhang
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 4
    item: Ma L
      type: Person
      first name: Li
      last name: Ma
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 5
    item: Jing J
      type: Person
      first name: Junjun
      last name: Jing
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 6
    item: Feng J
      type: Person
      first name: Jifan
      last name: Feng
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 7
    item: Ho TV
      type: Person
      first name: Thach-Vu
      last name: Ho
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 8
    item: Wen Q
      type: Person
      first name: Quan
      last name: Wen
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA.
  slot:
    index: 9
    item: Chai Y
      type: Person
      first name: Yang
      last name: Chai
      member of: Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA, 90033, USA. ychai@usc.edu.
created: 2024-6-24T00:42
date last updated: 2025-01-20
issued: 2024-06-24
dp: 2024 Jun 24
created: 2024-6-23T23:07
ISSN: 2095-4700
has issn l: 2095-4700
issue: 1
has NLM journal title abbreviation: Bone Res
publication name: Bone research
language: eng
has national library of medicine journal id: 101608652
derived from: NLM
pg: 37
has place of publication: China
has primary subject term: D060449Q000502
has primary subject term: D014092Q000254Q000378Q000166
has primary subject term: D040542
has primary subject term: D005346Q000378Q000235
has subject term: D000818
has subject term: D051379
has subject term: D002454
has subject term: D013234Q000378
has subject term: D051496Q000378Q000235
has subject term: D007473
source: Bone Res. 2024-06-24;12(1):37.
volume: 12

Ten-Year Efficacy of Transoral Surgery for Squamous Carcinoma of the Lateral Oropharynx.
pmid: 38932658
abstract: To document the 10-year results of transoral mandibular preservation surgery for patients with T1-2 squamous cell carcinoma (SCC) arising from the lateral oropharynx.This was a retrospective 30-year review using STROBE guidelines at an academic, tertiary referral center. A total of 294 patients with T1-2 SCC of the lateral oropharynx were reviewed. Only 19% of patients were never-smokers, suggesting a predominantly HPV-negative population. All patients had transoral mandibular preservation surgery. Follow-up therapy included neck dissection (76.5%), induction chemotherapy (57.8%), and postoperative radiation therapy (31.6%) Local control, survival, and functional endpoints, as well as the consequences of local recurrence, were analyzed.The 10-year local disease control was 88.3%. Local recurrence was salvaged in 50% of cases, resulting in an overall 94.5% local control rate. The overall 10-year survival was 50%. Mortality was related to metachronous second primary cancer (MSPC) (29.2%), medical comorbidities (25.7%), uncontrolled local recurrence (10%), and complications following transoral resection (4.2%). In multivariate analysis, the development of an MSPC significantly increased (p < 0.005) the risk of death. Overall, 95.2% of patients achieved mandibular preservation. However, gastrostomy and tracheostomy dependence occurred in 1% and 0.3% of cases, respectively.For a patient population with a significant percentage of tobacco-associated oropharyngeal cancer (OPC), transoral surgery was associated with long-term minimal postoperative complications and a high rate of local control. MSPC was the main cause of death during the first 10 postoperative years. Such long-term figures support transoral surgery as an effective first-line treatment for early-stage predominantly tobacco-related OPC.4 Laryngoscope, 134:4564-4572, 2024.
rights: © 2024 The Author(s). The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.
doi: 10.1002/lary.31574
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Laccourreye O
      type: Person
      first name: Ollivier
      last name: Laccourreye
      member of: Université Paris Cité, Service d'Otorhinolaryngologie et de Chirurgie Cervico-Faciale, HEGP, AP-HP, Paris, France.
  slot:
    index: 2
    item: Garcia D
      type: Person
      first name: Dominique
      last name: Garcia
      member of: Université Paris Cité, Service d'Otorhinolaryngologie et de Chirurgie Cervico-Faciale, HEGP, AP-HP, Paris, France.
  slot:
    index: 3
    item: Rahman A
      type: Person
      first name: Arifeen
      last name: Rahman
      member of: Division of Head & Neck Surgery, Department of Otolaryngology, Stanford University, Palo Alto, California, U.S.A.
  slot:
    index: 4
    item: Holsinger FC
      type: Person
      first name: F Christopher
      last name: Holsinger
      member of: Division of Head & Neck Surgery, Department of Otolaryngology, Stanford University, Palo Alto, California, U.S.A.
created: 2024-6-27T06:42
date last updated: 2025-01-20
issued: 2024-11
dp: 2024 11
created: 2024-6-27T03:45
e ISSN: 1531-4995
has issn l: 0023-852X
issue: 11
has NLM journal title abbreviation: Laryngoscope
publication name: The Laryngoscope
language: eng
has national library of medicine journal id: 8607378
derived from: NLM
starting page: 4564
ending page: 4572
has place of publication: United States
has primary subject term: D009959Q000601Q000473Q000401
has primary subject term: D002294Q000601Q000473Q000401
has primary subject term: D009364Q000453
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D012189
has subject term: D008875
has subject term: D000368
has subject term: D000328
has subject term: D016896
has subject term: D000369
has subject term: D009367
has subject term: D005500
has subject term: D037981Q000379
has subject term: D015996
has subject term: D008334Q000601
source: Laryngoscope. 2024-11;134(11):4564-4572.
volume: 134

A mini review on recent progress of microfluidic systems for antibody development.
pmid: 38932846
abstract: Antibody is specific reagent that be utilized in various field of biomedical research. Monoclonal antibodies are mostly produced using two common techniques namely hybridoma and antibody engineering, which suffer from some limitations such as boring screening procedures, long production time, low efficacy and a degree of automation. To address these limitations, various microfluidics techniques have been developed for the antibody isolation and screening.This study specifically investigates nearly recent reports published in peer-reviewed journals indexed in various databases including Web of Science, Scopus, PubMed, Google Scholar, and Science Direct.In this study, we identified a total of seventy papers from a pool of 130 articles. These papers focus on the application of three major groups of microfluidic platforms, namely valves, microwells, and droplets, in the development of antibodies using hybridoma method and phage display technology. We provide a summary of these applications and also discuss the key findings in this field. Additionally, we illustrate our discussion with several examples to enhance understanding.Microfluidics has the potential to serve as a valuable tool in streamlining complex laboratory procedures involved in antibody discovery. However, it is important to note that microfluidics is limited to laboratory settings. Further enhancements are needed to address existing challenges and to make microfluidics a reliable, accurate, and cost-effective tool for antibody discovery.
rights: © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
has PII: 1386
doi: 10.1007/s40200-024-01386-7
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Omidfar K
      type: Person
      first name: Kobra
      last name: Omidfar
      member of: Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, IR Iran.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  slot:
    index: 2
    item: Kashanian S
      type: Person
      first name: Sohiela
      last name: Kashanian
      member of: Faculty of Chemistry, Razi University, Kermanshah, 6714414971 Iran.Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, 6714414971 Iran.
created: 2024-6-27T06:42
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-6-27T04:24
ISSN: 2251-6581
has issn l: 2251-6581
issue: 1
has NLM journal title abbreviation: J Diabetes Metab Disord
publication name: Journal of diabetes and metabolic disorders
language: eng
has national library of medicine journal id: 101590741
derived from: NLM
starting page: 323
ending page: 331
has place of publication: Switzerland
source: J Diabetes Metab Disord. 2024-06;23(1):323-331.
volume: 23

http://rdf.ncbi.nlm.nih.gov/pubmed/38949906
pmid: 38949906
abstract: Speed of processing (SOP) cognitive training may improve indicators of the quality of life (QoL) in people living with HIV. In this 2-year, longitudinal, randomized, controlled trial, 216 participants ages 40 years and older with HIV-associated neurocognitive disorder or borderline HIV-associated neurocognitive disorder were assigned to one of three groups: (a) 10 hr of SOP training (n = 70); (b) 20 hr of SOP training (n = 73), or (c) 10 hr of internet navigation control training (a contact control group; n = 73). Participants completed several QoL measures at baseline, posttest, and Year 1 and Year 2 follow-ups. Using linear mixed-effect models, no strong pattern of training effects across QoL outcomes was apparent, with small-magnitude, nonsignificant, between-group differences in depression, locus of control, and Medical Outcomes Study-HIV scales. In conclusion, despite prior work showing some transfer of SOP cognitive training improving QoL, that was not observed. Implications for research and practice are posited.
rights: Copyright © 2024 Association of Nurses in AIDS Care.
has PII: 00001782-202404000-00004
doi: 10.1097/JNC.0000000000000449
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Vance DE
      type: Person
      first name: David E
      last name: Vance
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 2
    item: Fazeli PL
      type: Person
      first name: Pariya L
      last name: Fazeli
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 3
    item: Azuero A
      type: Person
      first name: Andres
      last name: Azuero
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 4
    item: Frank JS
      type: Person
      first name: Jennifer S
      last name: Frank
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 5
    item: Wadley VG
      type: Person
      first name: Virginia G
      last name: Wadley
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 6
    item: Raper JL
      type: Person
      first name: James L
      last name: Raper
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 7
    item: Pope CN
      type: Person
      first name: Caitlin N
      last name: Pope
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 8
    item: Jacob A
      type: Person
      first name: Alexandra
      last name: Jacob
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  slot:
    index: 9
    item: Ball KK
      type: Person
      first name: Karlene K
      last name: Ball
      member of: David E. Vance is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Pariya L. Fazeli is an Associate Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Andres Azuero is a Professor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Jennifer S. Frank is an Instructor, School of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.Virginia G. Wadley is an Associate Professor (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.James L. Raper is a Professor and Director of the 1917 (HIV/AIDS) Clinic (retired), School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.Caitlin N. Pope is an Assistant Professor, Department of Health, Behavior & Society, University of Kentucky, Lexington, Kentucky, USA.Alexandra Jacob is a Medical Clinical Psychology Doctoral Student, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.Karlene K. Ball is a Professor, Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
created: 2024-7-1T18:49
date last updated: 2025-01-20
created: 2024-7-1T12:22
e ISSN: 1552-6917
has issn l: 1055-3290
issue: 2
has NLM journal title abbreviation: J Assoc Nurses AIDS Care
publication name: The Journal of the Association of Nurses in AIDS Care : JANAC
language: eng
has national library of medicine journal id: 9111870
derived from: NLM
starting page: 104
ending page: 121
has place of publication: United States
has primary subject term: D011788Q000523
has primary subject term: D015658Q000523Q000150
has subject term: D006801
has subject term: D008297
has subject term: D005260
has subject term: D008875
has subject term: D000328
has subject term: D000407
has subject term: D008137
has subject term: D016896
has subject term: D015928Q000379
has subject term: D003071
has subject term: D003863Q000523
has subject term: D019965
has subject term: D015526Q000523Q000628
has subject term: http://id.nlm.nih.gov/mesh/D000091942
source: J Assoc Nurses AIDS Care. ;35(2):104-121.
title: A 2-Year, Randomized, Clinical Trial Examining the Effects of Speed of Processing Cognitive Training on Quality-of-Life Indicators in Adults With HIV-Associated Neurocognitive Disorder in Birmingham, Alabama: Results of the Think Fast Study.
volume: 35

Editorial: Commercialization and industrialization of pharmacology of infectious diseases: 2022.
pmid: 38962313
has PII: 1438072
doi: 10.3389/fphar.2024.1438072
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Huang Y
      type: Person
      first name: Yanqin
      last name: Huang
      member of: Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, United States.Harvard Medical School, Boston, MA, United States.
  slot:
    index: 2
    item: Nang SC
      type: Person
      first name: Sue C
      last name: Nang
      member of: Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
  slot:
    index: 3
    item: Lin YW
      type: Person
      first name: Yu-Wei
      last name: Lin
      member of: Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.Malaya Translational and Clinical Pharmacometrics Group, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, Malaysia.Department of Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, Malaysia.Certara Drug Development Solutions, Certara, Radnor, PA, United States.
  slot:
    index: 4
    item: Sime F
      type: Person
      first name: Fekade
      last name: Sime
      member of: Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.
created: 2024-7-4T06:42
date last updated: 2025-01-20
issued: 2024
dp: 2024
created: 2024-7-4T04:19
ISSN: 1663-9812
has issn l: 1663-9812
has NLM journal title abbreviation: Front Pharmacol
publication name: Frontiers in pharmacology
language: eng
has national library of medicine journal id: 101548923
derived from: NLM
pg: 1438072
has place of publication: Switzerland
source: Front Pharmacol. 2024;15():1438072.
volume: 15

Temporal-specific single-cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets.
pmid: 38987092
has PII: S2095-9273(24)00462-6
doi: 10.1016/j.scib.2024.07.001
creator: OrderedList
  length: 13
  slot:
    index: 1
    item: Zhao W
      type: Person
      first name: Wenting
      last name: Zhao
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 2
    item: Chen J
      type: Person
      first name: Juan
      last name: Chen
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 3
    item: Xia Y
      type: Person
      first name: Yi
      last name: Xia
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 4
    item: Wei Z
      type: Person
      first name: Zhixi
      last name: Wei
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 5
    item: Wan S
      type: Person
      first name: Sitong
      last name: Wan
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 6
    item: Guo H
      type: Person
      first name: Huiyuan
      last name: Guo
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 7
    item: Hao Y
      type: Person
      first name: Yanling
      last name: Hao
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
  slot:
    index: 8
    item: Jiang W
      type: Person
      first name: Wenjian
      last name: Jiang
      member of: Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
  slot:
    index: 9
    item: Zhang H
      type: Person
      first name: Hongjia
      last name: Zhang
      member of: Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
  slot:
    index: 10
    item: Ren F
      type: Person
      first name: Fazheng
      last name: Ren
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. Electronic address: renfazheng@cau.edu.cn.
  slot:
    index: 11
    item: An P
      type: Person
      first name: Peng
      last name: An
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. Electronic address: an-peng@cau.edu.cn.
  slot:
    index: 12
    item: Luo Y
      type: Person
      first name: Yongting
      last name: Luo
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. Electronic address: luo.yongting@cau.edu.cn.
  slot:
    index: 13
    item: Luo J
      type: Person
      first name: Junjie
      last name: Luo
      member of: Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. Electronic address: luojj@cau.edu.cn.
created: 2024-7-11T00:42
date last updated: 2025-01-19
issued: 2025-01-30
dp: 2025 Jan 30
created: 2024-7-10T21:59
e ISSN: 2095-9281
has issn l: 2095-9273
issue: 2
has NLM journal title abbreviation: Sci Bull (Beijing)
publication name: Science bulletin
language: eng
has national library of medicine journal id: 101655530
derived from: NLM
starting page: 167
ending page: 171
has place of publication: Netherlands
source: Sci Bull (Beijing). 2025-01-30;70(2):167-171.
volume: 70

CSF multi-omics of intracerebral hemorrhage from onset to reperfusion underscores lipid metabolism in functional outcome.
pmid: 38971657
has PII: S2095-9273(24)00401-8
doi: 10.1016/j.scib.2024.06.005
creator: OrderedList
  length: 15
  slot:
    index: 1
    item: Jiang Y
      type: Person
      first name: Yibin
      last name: Jiang
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 2
    item: Lam SM
      type: Person
      first name: Sin Man
      last name: Lam
      member of: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  slot:
    index: 3
    item: Zhang S
      type: Person
      first name: Shuixian
      last name: Zhang
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 4
    item: Miao H
      type: Person
      first name: Huan
      last name: Miao
      member of: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  slot:
    index: 5
    item: Zhou Y
      type: Person
      first name: Yong
      last name: Zhou
      member of: Chongqing Key Laboratory on Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
  slot:
    index: 6
    item: Zhang Q
      type: Person
      first name: Qian
      last name: Zhang
      member of: Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 7
    item: Zhou T
      type: Person
      first name: Tengyuan
      last name: Zhou
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 8
    item: Feng H
      type: Person
      first name: Hui
      last name: Feng
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 9
    item: Ding N
      type: Person
      first name: Ning
      last name: Ding
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 10
    item: Wang H
      type: Person
      first name: Haomiao
      last name: Wang
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 11
    item: Luo R
      type: Person
      first name: Ran
      last name: Luo
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 12
    item: Yin Y
      type: Person
      first name: Yi
      last name: Yin
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 13
    item: Feng H
      type: Person
      first name: Hua
      last name: Feng
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  slot:
    index: 14
    item: Shui G
      type: Person
      first name: Guanghou
      last name: Shui
      member of: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: ghshui@genetics.ac.cn.
  slot:
    index: 15
    item: Hu R
      type: Person
      first name: Rong
      last name: Hu
      member of: Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address: huchrong@tmmu.edu.cn.
created: 2024-7-7T00:42
date last updated: 2025-01-19
issued: 2025-01-30
dp: 2025 Jan 30
created: 2024-7-6T21:57
e ISSN: 2095-9281
has issn l: 2095-9273
issue: 2
has NLM journal title abbreviation: Sci Bull (Beijing)
publication name: Science bulletin
language: eng
has national library of medicine journal id: 101655530
derived from: NLM
starting page: 162
ending page: 166
has place of publication: Netherlands
source: Sci Bull (Beijing). 2025-01-30;70(2):162-166.
volume: 70

Commentary: Clinical Predictors of Overall Survival in Very Elderly Patients With Glioblastoma: A National Cancer Database Multivariable Analysis.
pmid: 39007590
has PII: 00006123-202502000-00028
doi: 10.1227/neu.0000000000003116
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Pichardo-Rojas PS
      type: Person
      first name: Pavel S
      last name: Pichardo-Rojas
      member of: Vivian L. Smith Department of Neurosurgery, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston , Texas , USA.
  slot:
    index: 2
    item: Dono A
      type: Person
      first name: Antonio
      last name: Dono
      member of: Vivian L. Smith Department of Neurosurgery, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston , Texas , USA.
  slot:
    index: 3
    item: Esquenazi Y
      type: Person
      first name: Yoshua
      last name: Esquenazi
      member of: Vivian L. Smith Department of Neurosurgery, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston , Texas , USA.Memorial Hermann Hospital-TMC, Houston , Texas , USA.
created: 2024-7-15T12:42
date last updated: 2025-01-20
issued: 2025-02-01
dp: 2025 Feb 01
created: 2024-7-15T09:03
e ISSN: 1524-4040
has issn l: 0148-396X
issue: 2
has NLM journal title abbreviation: Neurosurgery
publication name: Neurosurgery
language: eng
has national library of medicine journal id: 7802914
derived from: NLM
starting page: e27
ending page: e28
has place of publication: United States
source: Neurosurgery. 2025-02-01;96(2):e27-e28.
volume: 96

AcMNPV-miR-2 affects Autographa californica nucleopolyhedrovirus infection by regulating the expression of ac28 and several other viral early genes.
pmid: 39023251
abstract: Virus-encoded microRNAs (miRNAs) exert diverse regulatory roles in the biological processes of both viruses and hosts. This study delves into the functions of AcMNPV-miR-2, an early miRNA encoded by Autographa californica multiple nucleopolyhedrovirus (AcMNPV). AcMNPV-miR-2 targets viral early genes ac28 (lef-6), ac37 (lef-11), ac49, and ac63. Overexpression of AcMNPV-miR-2 leads to reduced production of infectious budded virions (BVs) and diminished viral DNA replication. Delayed polyhedron formation was observed through light and transmission electron microscopy, and the larval lifespan extended in oral infection assays. Moreover, the mRNA expression levels of two Lepidoptera-specific immune-related proteins, Gloverin and Spod-11-tox, significantly decreased. These findings indicate that AcMNPV-miR-2 restrains viral load, reducing host immune sensitivity. This beneficial effect enables the virus to combat host defense mechanisms and reside within the host for an extended duration.Virus-encoded miRNAs have been extensively studied for their pivotal roles in finetuning viral infections. Baculoviruses, highly pathogenic in insects, remain underexplored concerning their encoded miRNAs. Previous reports outlined three AcMNPV-encoded miRNAs, AcMNPV-miR-1, -miR-3, and -miR-4. This study delves into the functions of another AcMNPV-encoded miRNA, AcMNPV-miR-2 (Ac-miR-2). Through a comprehensive analysis of target gene expression, the impact on larvae, and variations in host immune-related gene expression, we elucidate a functional pathway for Ac-miR-2. This miRNA suppresses viral load and infectivity and prolongs lifespans of infected larva by downregulating specific viral early genes and host immune-related genes. These mechanisms ultimately serve the virus's primary goal of enhanced propagation. Our study significantly contributes to understanding of the intricate regulatory mechanisms of virus-encoded miRNAs in baculovirus infections.
doi: 10.1128/jvi.00570-24
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Yu X
      type: Person
      first name: Xinghua
      last name: Yu
      member of: School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 2
    item: Teng T
      type: Person
      first name: Tingkai
      last name: Teng
      member of: School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 3
    item: Duan Z
      type: Person
      first name: Zhuowen
      last name: Duan
      member of: School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
  slot:
    index: 4
    item: Wang J
      type: Person
      first name: Jinwen
      last name: Wang
      member of: School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
created: 2024-7-18T12:43
date last updated: 2025-01-20
issued: 2024-08-20
dp: 2024 Aug 20
created: 2024-7-18T09:02
e ISSN: 1098-5514
has issn l: 0022-538X
issue: 8
has NLM journal title abbreviation: J Virol
publication name: Journal of virology
language: eng
has national library of medicine journal id: 0113724
derived from: NLM
pg: e0057024
has place of publication: United States
has primary subject term: D017924Q000235
has primary subject term: D035683Q000235Q000378
has primary subject term: D014779
has primary subject term: D015967
has primary subject term: D014764Q000235Q000378
has subject term: D000818
has subject term: D007814Q000821Q000235
has subject term: D061987
has subject term: D019562
has subject term: D018411Q000821
has subject term: D014771Q000235Q000378
source: J Virol. 2024-08-20;98(8):e0057024.
volume: 98

Geometry-induced friction at a soft interface.
pmid: 39024108
abstract: Soft and biological matter come in a variety of shapes and geometries. When soft surfaces that do not fit into each other due to a mismatch in Gaussian curvatures form an interface, beautiful geometry-induced patterns are known to emerge. In this paper, we study the effect of geometry on the dynamical response of soft surfaces moving relative to each other. Using a simple experimental scheme, we measure friction between a highly bendable thin polymer sheet and a hydrogel substrate. At this soft and low-friction interface, we find a strong dependence of friction on the relative geometry of the two surfaces-a flat sheet experiences significantly larger friction on a spherical substrate than on flat or cylindrical substrate. We show that the stress developed in the sheet due to its geometrically incompatible confinement is responsible for the enhanced friction. This mechanism also leads to a transition in the nature of friction as the sheet radius is increased beyond a critical value. Our finding reveals a hitherto unnoticed mechanism based on an interplay between geometry and elasticity that may influence friction significantly in soft, biological, and nanoscale systems. In particular, it provokes us to reexamine our understanding of phenomena such as the curvature dependence of biological cell mobility.
doi: 10.1073/pnas.2320068121
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Chawla A
      type: Person
      first name: Aashna
      last name: Chawla
      member of: Department of Physics, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
  slot:
    index: 2
    item: Kumar D
      type: Person
      first name: Deepak
      last name: Kumar
      member of: Department of Physics, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
created: 2024-7-18T18:43
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-18T12:42
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2320068121
has place of publication: United States
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2320068121.
volume: 121

Linking faces to social cognition: The temporal pole as a potential social switch.
pmid: 39024106
doi: 10.1073/pnas.2411735121
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Dipani A
      type: Person
      first name: Alish
      last name: Dipani
      member of: Cognition and Brain Science, School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332.Center of Excellence in Computational Cognition, Georgia Institute of Technology, Atlanta, GA 30332.
  slot:
    index: 2
    item: McNeal N
      type: Person
      first name: Nikolas
      last name: McNeal
      member of: School of Mathematics, Georgia Institute of Technology, Atlanta, GA 30332.
  slot:
    index: 3
    item: Ratan Murty NA
      type: Person
      first name: N Apurva
      last name: Ratan Murty
      member of: Cognition and Brain Science, School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332.Center of Excellence in Computational Cognition, Georgia Institute of Technology, Atlanta, GA 30332.
created: 2024-7-18T18:42
date last updated: 2025-01-20
issued: 2024-07-30
dp: 2024 Jul 30
created: 2024-7-18T12:42
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 31
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2411735121
has place of publication: United States
has primary subject term: http://id.nlm.nih.gov/mesh/D000083282
has subject term: D006801
has subject term: D013702Q000502
has subject term: D005145
has subject term: D000066499Q000502
source: Proc Natl Acad Sci U S A. 2024-07-30;121(31):e2411735121.
volume: 121

HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment.
pmid: 39022295
abstract: People living with HIV (PLWH) experience high rates of childhood trauma exposure, which is a significant risk factor for the development of posttraumatic stress disorder (PTSD). Because Black Americans living in urban environments are exposed to high levels of trauma, suffer from chronic PTSD, and are at increased risk for HIV infection, it is important to understand how HIV status interacts with childhood maltreatment to influence PTSD symptom severity and underlying psychophysiology.The current cross-sectional study assessed whether HIV status interacts with childhood maltreatment to influence PTSD symptom severity and heart rate variability during a dark-enhanced startle (DES) task in 88 Black women with (n=30) and without HIV (n=58).HIV was associated with greater PTSD symptom severity only in women with low levels of childhood maltreatment (p=.024). Startle potentiation during DES was highest in women living without HIV and with high childhood maltreatment (p=.018). In women who had experienced low levels of childhood maltreatment, respiratory sinus arrhythmia (RSA) was lower during the dark phase of DES in women living without HIV than women living with HIV (WLWH), (p=.046). RSA during the light phase of DES was lower in WLWH than in women living without HIV (p=.042).In the current sample of Black women, HIV status was associated with PTSD symptom severity in a manner dependent on level of childhood maltreatment, suggesting that HIV status may be an important factor to consider for behavioral and pharmacological treatment strategies for PTSD. Additionally, HIV status is associated with lower percent potentiation to darkness and lower RSA during the light phase of DES, suggesting physiological mechanisms by which HIV may contribute to PTSD symptoms in individuals exposed to low levels of childhood maltreatment.
doi: 10.1080/10253890.2024.2303634
creator: OrderedList
  length: 14
  slot:
    index: 1
    item: Michopoulos V
      type: Person
      first name: Vasiliki
      last name: Michopoulos
      member of: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.Emory National Primate Research Center, Atlanta, Georgia.
  slot:
    index: 2
    item: Rocha M
      type: Person
      first name: Mariana
      last name: Rocha
      member of: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
  slot:
    index: 3
    item: Hinrichs R
      type: Person
      first name: Rebecca
      last name: Hinrichs
      member of: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
  slot:
    index: 4
    item: Turkson S
      type: Person
      first name: Susie
      last name: Turkson
      member of: Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA.
  slot:
    index: 5
    item: Dyer S
      type: Person
      first name: Samya
      last name: Dyer
      member of: Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA.
  slot:
    index: 6
    item: Howell P
      type: Person
      first name: Paul
      last name: Howell
      member of: Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA.
  slot:
    index: 7
    item: Heaton EC
      type: Person
      first name: Elizabeth C
      last name: Heaton
      member of: Emory National Primate Research Center, Atlanta, Georgia.
  slot:
    index: 8
    item: Hart J
      type: Person
      first name: Jakayla
      last name: Hart
      member of: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
  slot:
    index: 9
    item: Powers A
      type: Person
      first name: Abigail
      last name: Powers
      member of: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
  slot:
    index: 10
    item: Mekawi Y
      type: Person
      first name: Yara
      last name: Mekawi
      member of: University of Louisville, Department of Psychological and Brain Sciences, Louisville, Kentucky.
  slot:
    index: 11
    item: Carter S
      type: Person
      first name: Sierra
      last name: Carter
      member of: Department of Psychology, Georgia State University, Atlanta, Georgia.
  slot:
    index: 12
    item: Ofotokun I
      type: Person
      first name: Ighovwerha
      last name: Ofotokun
      member of: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.Grady Health System, Atlanta, GA.
  slot:
    index: 13
    item: Jovanovic T
      type: Person
      first name: Tanja
      last name: Jovanovic
      member of: Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan.
  slot:
    index: 14
    item: Neigh G
      type: Person
      first name: Gretchen
      last name: Neigh
      member of: Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA.
created: 2024-7-18T06:42
date last updated: 2025-01-20
issued: 2024
dp: 2024
created: 2024-7-18T04:46
e ISSN: 1607-8888
has issn l: 1025-3890
issue: 1
has NLM journal title abbreviation: Stress
publication name: Stress (Amsterdam, Netherlands)
language: eng
has national library of medicine journal id: 9617529
derived from: NLM
has place of publication: England
has primary subject term: D013313Q000503Q000523
has primary subject term: D006339Q000502
has primary subject term: D013216Q000502
has primary subject term: D015658Q000503Q000523
has primary subject term: D054523Q000523
has primary subject term: D001741
has subject term: D006801
has subject term: D005260
has subject term: D000328
has subject term: D003430
has subject term: D008875
has subject term: D012720
has subject term: D011603
has subject term: D065809Q000502
source: Stress. 2024;27(1):.
volume: 27

Entropy drives the ligand recognition in G-protein-coupled receptor subtypes.
pmid: 39024109
abstract: Achieving ligand subtype selectivity within highly homologous subtypes of G-protein-coupled receptor (GPCR) is critical yet challenging for GPCR drug discovery, primarily due to the unclear mechanism underlying ligand subtype selectivity, which hampers the rational design of subtype-selective ligands. Herein, we disclose an unusual molecular mechanism of entropy-driven ligand recognition in cannabinoid (CB) receptor subtypes, revealed through atomic-level molecular dynamics simulations, cryoelectron microscopy structure, and mutagenesis experiments. This mechanism is attributed to the distinct conformational dynamics of the receptor's orthosteric pocket, leading to variations in ligand binding entropy and consequently, differential binding affinities, which culminate in specific ligand recognition. We experimentally validated this mechanism and leveraged it to design ligands with enhanced or ablated subtype selectivity. One such ligand demonstrated favorable pharmacokinetic properties and significant efficacy in rodent inflammatory analgesic models. More importantly, it is precisely due to the high subtype selectivity obtained based on this mechanism that this ligand does not show addictive properties in animal models. Our findings elucidate the unconventional role of entropy in CB receptor subtype selectivity and suggest a strategy for rational design of ligands to achieve entropy-driven subtype selectivity for many pharmaceutically important GPCRs.
doi: 10.1073/pnas.2401091121
creator: OrderedList
  length: 21
  slot:
    index: 1
    item: Yang X
      type: Person
      first name: Xin
      last name: Yang
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 2
    item: Zhou P
      type: Person
      first name: Pei
      last name: Zhou
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 3
    item: Shen S
      type: Person
      first name: Siyuan
      last name: Shen
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 4
    item: Hu Q
      type: Person
      first name: Qian
      last name: Hu
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 5
    item: Tian C
      type: Person
      first name: Chenyu
      last name: Tian
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 6
    item: Xia A
      type: Person
      first name: Anjie
      last name: Xia
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 7
    item: Wang Y
      type: Person
      first name: Yifei
      last name: Wang
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 8
    item: Yang Z
      type: Person
      first name: Zhiqian
      last name: Yang
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 9
    item: Nan J
      type: Person
      first name: Jinshan
      last name: Nan
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 10
    item: Zhou Y
      type: Person
      first name: Yangli
      last name: Zhou
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 11
    item: Chen S
      type: Person
      first name: Shasha
      last name: Chen
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 12
    item: Tian X
      type: Person
      first name: Xiaowen
      last name: Tian
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 13
    item: Wu C
      type: Person
      first name: Chao
      last name: Wu
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 14
    item: Lin G
      type: Person
      first name: Guifeng
      last name: Lin
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 15
    item: Zhang L
      type: Person
      first name: Liting
      last name: Zhang
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 16
    item: Wang K
      type: Person
      first name: Kexin
      last name: Wang
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 17
    item: Zheng T
      type: Person
      first name: Tao
      last name: Zheng
      member of: Engineering Research Center of Medical Information Technology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 18
    item: Zou J
      type: Person
      first name: Jun
      last name: Zou
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 19
    item: Yan W
      type: Person
      first name: Wei
      last name: Yan
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  slot:
    index: 20
    item: Shao Z
      type: Person
      first name: Zhenhua
      last name: Shao
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Division of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Frontier Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan 610212, China.
  slot:
    index: 21
    item: Yang S
      type: Person
      first name: Shengyong
      last name: Yang
      member of: Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.New Cornerstone Science Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.Frontier Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan 610212, China.
created: 2024-7-18T18:43
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-18T12:42
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2401091121
has place of publication: United States
has primary subject term: D019277
has primary subject term: D056004
has primary subject term: D043562Q000378Q000737
has subject term: D008024
has subject term: D000818
has subject term: D006801
has subject term: D011485
has subject term: D051379
has subject term: D020285
has subject term: D043882Q000378Q000737
has subject term: D001665
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2401091121.
volume: 121

Universal scaling in far-from-equilibrium quantum systems: An equivalent differential approach.
pmid: 39024112
abstract: Recent progress in out-of-equilibrium closed quantum systems has significantly advanced the understanding of mechanisms behind their evolution toward thermalization. Notably, the concept of nonthermal fixed points (NTFPs)-responsible for the emergence of spatiotemporal universal scaling in far-from-equilibrium systems-has played a crucial role in both theoretical and experimental investigations. In this work, we introduce a differential equation that has the universal scaling associated with NTFPs as a solution. The advantage of working with a differential equation, rather than only with its solution, is that we can extract several insightful properties not necessarily present in the solution alone. How the differential equation is derived allows physical interpretation of the universal exponents in terms of the time dependence of the amplitude of the distributions and their momentum scaling. Employing two limiting cases of the equation, we determined the universal exponents related to the scaling using the distributions near just two momentum values. We established a solid agreement with previous investigations by validating this approach with three distinct physical systems. This consistency highlights the universal nature of scaling due to NTFPs and emphasizes the predictive capabilities of the proposed differential equation. Moreover, under specific conditions, the equation predicts a power-law related to the ratio of the two universal exponents, leading to implications concerning particle and energy transport. This suggests that the observed power-laws in far-from-equilibrium turbulent fluids could be related to the universal scaling due to NTFPs, potentially offering insights into the study of turbulence.
doi: 10.1073/pnas.2404828121
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Madeira L
      type: Person
      first name: Lucas
      last name: Madeira
      member of: Física e Ciência dos Materiais, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos 13560-970, Brazil.
  slot:
    index: 2
    item: García-Orozco AD
      type: Person
      first name: Arnol D
      last name: García-Orozco
      member of: Física e Ciência dos Materiais, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos 13560-970, Brazil.
  slot:
    index: 3
    item: Moreno-Armijos MA
      type: Person
      first name: Michelle A
      last name: Moreno-Armijos
      member of: Física e Ciência dos Materiais, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos 13560-970, Brazil.
  slot:
    index: 4
    item: Fritsch AR
      type: Person
      first name: Amilson R
      last name: Fritsch
      member of: Física e Ciência dos Materiais, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos 13560-970, Brazil.
  slot:
    index: 5
    item: Bagnato VS
      type: Person
      first name: Vanderlei S
      last name: Bagnato
      member of: Física e Ciência dos Materiais, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos 13560-970, Brazil.Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843.Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843.
created: 2024-7-18T18:43
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-18T12:42
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2404828121
has place of publication: United States
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2404828121.
volume: 121

APC/C prevents a noncanonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest.
pmid: 39024113
abstract: Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating cells, premature S phase entry is avoided by the E3 ubiquitin ligase anaphasepromoting complex/cyclosome (APC/C), although the APC/C substrates whose degradation restrains G1-S progression are not fully known. The APC/C is also active in arrested cells that exited the cell cycle, but it is not clear whether APC/C maintains all types of arrest. Here, by expressing the APC/C inhibitor, EMI1, we show that APC/C activity is essential to prevent S phase entry in cells arrested by pharmacological cyclin-dependent kinases 4 and 6 (CDK4/6) inhibition (Palbociclib). Thus, active protein degradation is required for arrest alongside repressed cell cycle gene expression. The mechanism of rapid and robust arrest bypass from inhibiting APC/C involves CDKs acting in an atypical order to inactivate retinoblastoma-mediated E2F repression. Inactivating APC/C first causes mitotic cyclin B accumulation which then promotes cyclin A expression. We propose that cyclin A is the key substrate for maintaining arrest because APC/C-resistant cyclin A, but not cyclin B, is sufficient to induce S phase entry. Cells bypassing arrest from CDK4/6 inhibition initiate DNA replication with severely reduced origin licensing. The simultaneous accumulation of S phase licensing inhibitors, such as cyclin A and geminin, with G1 licensing activators disrupts the normal order of G1-S progression. As a result, DNA synthesis and cell proliferation are profoundly impaired. Our findings predict that cancers with elevated EMI1 expression will tend to escape CDK4/6 inhibition into a premature, underlicensed S phase and suffer enhanced genome instability.
doi: 10.1073/pnas.2319574121
creator: OrderedList
  length: 9
  slot:
    index: 1
    item: Mouery BL
      type: Person
      first name: Brandon L
      last name: Mouery
      member of: Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 2
    item: Baker EM
      type: Person
      first name: Eliyambuya M
      last name: Baker
      member of: Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
  slot:
    index: 3
    item: Mei L
      type: Person
      first name: Liu
      last name: Mei
      member of: Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 4
    item: Wolff SC
      type: Person
      first name: Samuel C
      last name: Wolff
      member of: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Computational Medicine Program, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 5
    item: Mills CA
      type: Person
      first name: Christine A
      last name: Mills
      member of: University of North Carolina Proteomics Core Facility, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 6
    item: Fleifel D
      type: Person
      first name: Dalia
      last name: Fleifel
      member of: Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 7
    item: Mulugeta N
      type: Person
      first name: Nebyou
      last name: Mulugeta
      member of: Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 8
    item: Herring LE
      type: Person
      first name: Laura E
      last name: Herring
      member of: University of North Carolina Proteomics Core Facility, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
  slot:
    index: 9
    item: Cook JG
      type: Person
      first name: Jeanette Gowen
      last name: Cook
      member of: Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
created: 2024-7-18T18:43
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-18T12:42
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2319574121
has place of publication: United States
has primary subject term: D051361Q000378Q000235
has primary subject term: D051358Q000378Q000235Q000037
has subject term: D006801
has subject term: D064173Q000378Q000235
has subject term: D045744
has subject term: D016196Q000187
has subject term: D011725Q000494
has subject term: D010879Q000494
has subject term: D018797Q000378Q000235
has subject term: D050684Q000378Q000235
has subject term: D059447Q000187
has subject term: D016213Q000378Q000235
has subject term: D044783
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2319574121.
volume: 121

Oxygen-bridging Fe, Co dual-metal dimers boost reversible oxygen electrocatalysis for rechargeable Zn-air batteries.
pmid: 39024111
abstract: Rechargeable zinc-air batteries (ZABs) are regarded as a remarkably promising alternative to current lithium-ion batteries, addressing the requirements for large-scale high-energy storage. Nevertheless, the sluggish kinetics involving oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) hamper the widespread application of ZABs, necessitating the development of high-efficiency and durable bifunctional electrocatalysts. Here, we report oxygen atom-bridged Fe, Co dual-metal dimers (FeOCo-SAD), in which the active site Fe-O-Co-N6 moiety boosts exceptional reversible activity toward ORR and OER in alkaline electrolytes. Specifically, FeOCo-SAD achieves a half-wave potential (E1/2) of 0.87 V for ORR and an overpotential of 310 mV at a current density of 10 mA cm-2 for OER, with a potential gap (ΔE) of only 0.67 V. Meanwhile, FeOCo-SAD manifests high performance with a peak power density of 241.24 mW cm-2 in realistic rechargeable ZABs. Theoretical calculations demonstrate that the introduction of an oxygen bridge in the Fe, Co dimer induced charge spatial redistribution around Fe and Co atoms. This enhances the activation of oxygen and optimizes the adsorption/desorption dynamics of reaction intermediates. Consequently, energy barriers are effectively reduced, leading to a strong promotion of intrinsic activity toward ORR and OER. This work suggests that oxygen-bridging dual-metal dimers offer promising prospects for significantly enhancing the performance of reversible oxygen electrocatalysis and for creating innovative catalysts that exhibit synergistic effects and electronic states.
doi: 10.1073/pnas.2404013121
creator: OrderedList
  length: 12
  slot:
    index: 1
    item: Zhou Q
      type: Person
      first name: Qixing
      last name: Zhou
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 2
    item: Xue W
      type: Person
      first name: Wendan
      last name: Xue
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 3
    item: Cui X
      type: Person
      first name: Xun
      last name: Cui
      member of: State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430200, People's Republic of China.
  slot:
    index: 4
    item: Wang P
      type: Person
      first name: Pengfei
      last name: Wang
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 5
    item: Zuo S
      type: Person
      first name: Sijin
      last name: Zuo
      member of: State of Key Laboratory of Natural Medicines School of Engineering, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
  slot:
    index: 6
    item: Mo F
      type: Person
      first name: Fan
      last name: Mo
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 7
    item: Li C
      type: Person
      first name: Chengzhi
      last name: Li
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 8
    item: Liu G
      type: Person
      first name: Gaolei
      last name: Liu
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 9
    item: Ouyang S
      type: Person
      first name: Shaohu
      last name: Ouyang
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 10
    item: Zhan S
      type: Person
      first name: Sihui
      last name: Zhan
      member of: Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Carbon Neutrality Interdisciplinary Science Centre/College of Environmental Science and Engineering, Nankai University, Tianjin 300350, People's Republic of China.
  slot:
    index: 11
    item: Chen J
      type: Person
      first name: Juan
      last name: Chen
      member of: College of Environment, Hohai University, Nanjing 210098, People's Republic of China.
  slot:
    index: 12
    item: Wang C
      type: Person
      first name: Chao
      last name: Wang
      member of: College of Environment, Hohai University, Nanjing 210098, People's Republic of China.
created: 2024-7-18T18:42
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-18T12:42
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2404013121
has place of publication: United States
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2404013121.
volume: 121

An aldolase-dependent phloroglucinol degradation pathway in Collinsella sp. zg1085.
pmid: 39028195
abstract: Phloroglucinol (1,3,5-trihydroxybenzene) is a key intermediate in the degradation of polyphenols such as flavonoids and hydrolysable tannins and can be used by certain bacteria as a carbon and energy source for growth. The identification of enzymes that participate in the fermentation of phloroglucinol to acetate and butyrate in Clostridia was recently reported. In this study, we present the discovery and characterization of a novel metabolic pathway for phloroglucinol degradation in the bacterium Collinsella sp. zg1085, from marmot respiratory tract. In both the Clostridial and Collinsella pathways, phloroglucinol is first reduced to dihydrophoroglucinol by the NADPH-dependent phloroglucinol reductase (PGR), followed by ring opening to form (S)-3-hydroxy-5-oxohexanoate by a Mn2+-dependent dihydrophloroglucinol cyclohydrolase (DPGC). In the Collinsella pathway, (S)-3-hydroxy-5-oxohexanoate is then cleaved to form malonate semialdehyde and acetone by a newly identified aldolase (HOHA). Finally, a NADP+-dependent malonate-semialdehyde dehydrogenase converts malonate semialdehyde to CO2 and acetyl-CoA, an intermediate in carbon and energy metabolism. Recombinant expression of the Collinsella PGR, DPGC, and HOHA in E. coli enabled the conversion of phloroglucinol into acetone, providing support for the proposed pathway. Experiments with Olsenella profusa, another bacterium containing the gene cluster of interest, show that the PGR, DPGC, HOHA, and MSDH are induced by phloroglucinol. Our findings add to the variety of metabolic pathways for the degradation of phloroglucinol, a widely distributed phenolic compound, in the anaerobic microbiome.IMPORTANCEPhloroglucinol is an important intermediate in the bacterial degradation of polyphenols, a highly abundant class of plant natural products. Recent research has identified key enzymes of the phloroglucinol degradation pathway in butyrate-producing anaerobic bacteria, which involves cleavage of a linear triketide intermediate[cell cut: 2386 characters, first 2000 kept]
doi: 10.1128/aem.01047-24
creator: OrderedList
  length: 6
  slot:
    index: 1
    item: Li Y
      type: Person
      first name: Yating
      last name: Li
      member of: Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China.Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China.Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
  slot:
    index: 2
    item: Xu T
      type: Person
      first name: Tong
      last name: Xu
      member of: Department of Pharmacy, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou, Jiangsu, China.
  slot:
    index: 3
    item: Tu Y
      type: Person
      first name: Yanqin
      last name: Tu
      member of: Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China.Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China.Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
  slot:
    index: 4
    item: Li T
      type: Person
      first name: Tong
      last name: Li
      member of: Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China.Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China.Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
  slot:
    index: 5
    item: Wei Y
      type: Person
      first name: Yifeng
      last name: Wei
      member of: Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
  slot:
    index: 6
    item: Zhou Y
      type: Person
      first name: Yan
      last name: Zhou
      member of: Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China.Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China.Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, China.
created: 2024-7-19T12:41
date last updated: 2025-01-20
issued: 2024-08-21
dp: 2024 08 21
created: 2024-7-19T09:03
e ISSN: 1098-5336
has issn l: 0099-2240
issue: 8
has NLM journal title abbreviation: Appl Environ Microbiol
publication name: Applied and environmental microbiology
language: eng
has national library of medicine journal id: 7605801
derived from: NLM
pg: e0104724
has place of publication: United States
has primary subject term: D010696Q000378Q000031
has primary subject term: D053858Q000235
has subject term: D001426Q000378Q000235
has subject term: D000446Q000378Q000235
has subject term: D000818
source: Appl Environ Microbiol. 2024-08-21;90(8):e0104724.
volume: 90

A geometrical theory of gliding motility based on cell shape and surface flow.
pmid: 39028692
abstract: Gliding motility proceeds with little changes in cell shape and often results from actively driven surface flows of adhesins binding to the extracellular environment. It allows for fast movement over surfaces or through tissue, especially for the eukaryotic parasites from the phylum apicomplexa, which includes the causative agents of the widespread diseases malaria and toxoplasmosis. We have developed a fully three-dimensional active particle theory which connects the self-organized, actively driven surface flow over a fixed cell shape to the resulting global motility patterns. Our analytical solutions and numerical simulations show that straight motion without rotation is unstable for simple shapes and that straight cell shapes tend to lead to pure rotations. This suggests that the curved shapes of Plasmodium sporozoites and Toxoplasma tachyzoites are evolutionary adaptations to avoid rotations without translation. Gliding motility is also used by certain myxo- or flavobacteria, which predominantly move on flat external surfaces and with higher control of cell surface flow through internal tracks. We extend our theory for these cases. We again find a competition between rotation and translation and predict the effect of internal track geometry on overall forward speed. While specific mechanisms might vary across species, in general, our geometrical theory predicts and explains the rotational, circular, and helical trajectories which are commonly observed for microgliders. Our theory could also be used to design synthetic microgliders.
doi: 10.1073/pnas.2410708121
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Lettermann L
      type: Person
      first name: Leon
      last name: Lettermann
      member of: Institute for Theoretical Physics, Heidelberg University, Heidelberg 69120, Germany.Bioquant-Center, Heidelberg University, Heidelberg 69120, Germany.
  slot:
    index: 2
    item: Ziebert F
      type: Person
      first name: Falko
      last name: Ziebert
      member of: Institute for Theoretical Physics, Heidelberg University, Heidelberg 69120, Germany.Bioquant-Center, Heidelberg University, Heidelberg 69120, Germany.
  slot:
    index: 3
    item: Schwarz US
      type: Person
      first name: Ulrich S
      last name: Schwarz
      member of: Institute for Theoretical Physics, Heidelberg University, Heidelberg 69120, Germany.Bioquant-Center, Heidelberg University, Heidelberg 69120, Germany.
created: 2024-7-19T18:42
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-19T13:23
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2410708121
has place of publication: United States
has primary subject term: D048430Q000502
has primary subject term: D008954
has subject term: D002465Q000502
has subject term: D014122Q000502
has subject term: D010961Q000502
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2410708121.
volume: 121

Difference in microbial community structure along a gradient of crater altitude: insights from the Nushan volcano.
pmid: 39028194
abstract: The variation in the soil microbial community along the altitude gradient has been widely documented. However, the structure and function of the microbial communities distributed along the altitude gradient in the crater still need to be determined. We gathered soil specimens from different elevations within the Nushan volcano crater to bridge this knowledge gap. We investigated the microbial communities of bacteria and fungi in the soil. It is noteworthy that the microbial alpha diversity peaks in the middle of the crater. However, network analysis shows that bacterial (nodes 760 vs 613 vs 601) and fungal (nodes 328 vs 224 vs 400) communities are most stable at the bottom and top of the crater, respectively. Furthermore, the soil microbial network exhibited a decline, followed by an increase across varying altitudes. The core microorganisms displayed the highest correlation with pH and alkaline phosphatase (AP, as determined through redundancy analysis (RDA) and Mantel tests for correlation analysis. The fungal community has a higher number of core microorganisms, while the bacterial core microorganisms demonstrate greater susceptibility to environmental factors. In conclusion, we utilized Illumina sequencing techniques to assess the disparities in the structure and function of bacteria and fungi in the soil.IMPORTANCEThese findings serve as a foundation for future investigations on microbial communities present in volcanic soil.
doi: 10.1128/aem.00753-24
creator: OrderedList
  length: 7
  slot:
    index: 1
    item: Chen J
      type: Person
      first name: Jin
      last name: Chen
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
  slot:
    index: 2
    item: Cui Y
      type: Person
      first name: Ye
      last name: Cui
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
  slot:
    index: 3
    item: Xiao Q
      type: Person
      first name: Qingchen
      last name: Xiao
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
  slot:
    index: 4
    item: Lin K
      type: Person
      first name: Keqin
      last name: Lin
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
  slot:
    index: 5
    item: Wang B
      type: Person
      first name: Boyan
      last name: Wang
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
  slot:
    index: 6
    item: Zhou J
      type: Person
      first name: Jing
      last name: Zhou
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
  slot:
    index: 7
    item: Li X
      type: Person
      first name: Xiaoyu
      last name: Li
      member of: School of Life Sciences, Anhui Agricultural University, Hefei, China.National Engineering Laboratory of Crop Stress Resistance Breeding, Anhui Agricultural University, Hefei, China.Key Laboratory of Crop Stress Resistance and High-Quality Biology of Anhui Province, Anhui Agricultural University, Hefei, China.
created: 2024-7-19T12:41
date last updated: 2025-01-20
issued: 2024-08-21
dp: 2024 08 21
created: 2024-7-19T09:03
e ISSN: 1098-5336
has issn l: 0099-2240
issue: 8
has NLM journal title abbreviation: Appl Environ Microbiol
publication name: Applied and environmental microbiology
language: eng
has national library of medicine journal id: 7605801
derived from: NLM
pg: e0075324
has place of publication: United States
has primary subject term: D012988
has primary subject term: D000531
has primary subject term: D001419Q000235Q000145Q000302
has primary subject term: D005658Q000235Q000145Q000302
has primary subject term: D064307
has primary subject term: D018707
has subject term: D002681
source: Appl Environ Microbiol. 2024-08-21;90(8):e0075324.
volume: 90

On the friendship paradox and inversity: A network property with applications to privacy-sensitive network interventions.
pmid: 39028691
abstract: We provide the mathematical and empirical foundations of the friendship paradox in networks, often stated as Your friends have more friends than you. We prove a set of network properties on friends of friends and characterize the concepts of ego-based and alter-based means. We propose a network property called inversity that quantifies the imbalance in degrees across edges and prove that the sign of inversity determines the ordering between ego-based or alter-based means for any network, with implications for interventions. Network intervention problems like immunization benefit from using highly connected nodes. We characterize two intervention strategies based on the friendship paradox to obtain such nodes, with the alter-based and ego-based strategy. Both strategies provide provably guaranteed improvements for any network structure with variation in node degrees. We demonstrate that the proposed strategies obtain several-fold improvement (100-fold in some networks) in node degree relative to a random benchmark, for both generated and real networks. We evaluate how inversity informs which strategy works better based on network topology and show how network aggregation can alter inversity. We illustrate how the strategies can be used to control contagion of an epidemic spreading across a set of village networks, finding that these strategies require far fewer nodes to be immunized (less than 50%, relative to random). The interventions do not require knowledge of network structure, are privacy-sensitive, are flexible for time-sensitive action, and only require selected nodes to nominate network neighbors.
doi: 10.1073/pnas.2306412121
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kumar V
      type: Person
      first name: Vineet
      last name: Kumar
      member of: Yale School of Management, Yale University, New Haven, CT 06511.
  slot:
    index: 2
    item: Krackhardt D
      type: Person
      first name: David
      last name: Krackhardt
      member of: John Heinz III College of Public Policy and Management, Carnegie Mellon University, Pittsburgh, PA 15213.
  slot:
    index: 3
    item: Feld S
      type: Person
      first name: Scott
      last name: Feld
      member of: Department of Sociology, College of Liberal Arts, Purdue University, West Lafayette, IN 47907.
created: 2024-7-19T18:42
date last updated: 2025-01-20
issued: 2024-07-23
dp: 2024 Jul 23
created: 2024-7-19T13:23
e ISSN: 1091-6490
has issn l: 0027-8424
issue: 30
has NLM journal title abbreviation: Proc Natl Acad Sci U S A
publication name: Proceedings of the National Academy of Sciences of the United States of America
language: eng
has national library of medicine journal id: 7505876
derived from: NLM
pg: e2306412121
has place of publication: United States
source: Proc Natl Acad Sci U S A. 2024-07-23;121(30):e2306412121.
volume: 121

Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus.
pmid: 39028869
abstract: An exome sequencing strategy employed to identify pathogenic variants in patients with pediatric-onset systemic lupus or Evans syndrome resulted in the discovery of six novel monoallelic mutations in PTPN2. PTPN2 is a phosphatase that acts as an essential negative regulator of the JAK/STAT pathways. All mutations led to a loss of PTPN2 regulatory function as evidenced by in vitro assays and by hyperproliferation of patients' T cells. Furthermore, patients exhibited high serum levels of inflammatory cytokines, mimicking the profile observed in individuals with gain-of-function mutations in STAT factors. Flow cytometry analysis of patients' blood cells revealed typical alterations associated with autoimmunity and all patients presented with autoantibodies. These findings further supported the notion that a loss of function in negative regulators of cytokine pathways can lead to a broad spectrum of autoimmune manifestations and that PTPN2 along with SOCS1 haploinsufficiency constitute a new group of monogenic autoimmune diseases that can benefit from targeted therapy.
rights: © 2024 Jeanpierre et al.
has PII: 276866
doi: 10.1084/jem.20232337
creator: OrderedList
  length: 24
  slot:
    index: 1
    item: Jeanpierre M
      type: Person
      first name: Marie
      last name: Jeanpierre
      member of: Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163 , Paris, France, IHU-Imagine, Université de Paris, Paris, France.
  slot:
    index: 2
    item: Cognard J
      type: Person
      first name: Jade
      last name: Cognard
      member of: Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon , Lyon, France.
  slot:
    index: 3
    item: Tusseau M
      type: Person
      first name: Maud
      last name: Tusseau
      member of: Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon , Lyon, France.Department of Medical Genetics, Hospices Civils de Lyon, Bron, France.
  slot:
    index: 4
    item: Riller Q
      type: Person
      first name: Quentin
      last name: Riller
      member of: Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163 , Paris, France, IHU-Imagine, Université de Paris, Paris, France.
  slot:
    index: 5
    item: Bui LC
      type: Person
      first name: Linh-Chi
      last name: Bui
      member of: Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative , Paris, France.
  slot:
    index: 6
    item: Berthelet J
      type: Person
      first name: Jérémy
      last name: Berthelet
      member of: Université Paris Cité, CNRS, Epigenetics and Cell Fate , Paris, France.
  slot:
    index: 7
    item: Laurent A
      type: Person
      first name: Audrey
      last name: Laurent
      member of: National Referee Centre for Pediatric-Onset Rheumatism and Autoimmune Diseases, Hospices Civils de Lyon, Pediatric Nephrology, Rheumatology, Dermatology Unit, Mother and Children University Hospital ; Lyon, France.
  slot:
    index: 8
    item: Crickx E
      type: Person
      first name: Etienne
      last name: Crickx
      member of: Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163 , Paris, France, IHU-Imagine, Université de Paris, Paris, France.Service de Médecine Interne, Centre National de Référence des Cytopénies Auto-immunes de L'adulte, Hôpital Henri Mondor, Fédération Hospitalo-Universitaire TRUE InnovaTive TheRapy for ImmUne disordErs, Assistance Publique Hôpitaux de Paris, Université Paris Est Créteil , Créteil, France.
  slot:
    index: 9
    item: Parlato M
      type: Person
      first name: Marianna
      last name: Parlato
      member of: Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163 , Paris, France, IHU-Imagine, Université de Paris, Paris, France.
  slot:
    index: 10
    item: Stolzenberg MC
      type: Person
      first name: Marie-Claude
      last name: Stolzenberg
      member of: Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163 , Paris, France, IHU-Imagine, Université de Paris, Paris, France.
  slot:
    index: 11
    item: Suarez F
      type: Person
      first name: Felipe
      last name: Suarez
      member of: Department of Adult Hematology, Necker-Enfants Malades University Hospital and Centre de Référence des déficits Immunitaires Héréditaires, Assistance Publique Hôpitaux de Paris, INSERM U1163, Imagine Institute, Université Paris Cité, Paris, France.
  slot:
    index: 12
    item: Leverger G
      type: Person
      first name: Guy
      last name: Leverger
      member of: Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, UMR_S938, Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Sorbonne Université, Hôpital Armand Trousseau , Paris, France.
  slot:
    index: 13
    item: Aladjidi N
      type: Person
      first name: Nathalie
      last name: Aladjidi
      member of: Centre de Référence National des Cytopénies Auto-immunes de l'Enfant , Bordeaux, France.Pediatric Oncology Hemato-Immunology Unit, University Hospital, Plurithématique Centre d'Investigation Clinique, 1401, INSERM , Bordeaux, France.
  slot:
    index: 14
    item: Collardeau-Frachon S
      type: Person
      first name: Sophie
      last name: Collardeau-Frachon
      member of: Institute of Pathology, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1 , Lyon, France.Société Française de Foetopathologie Paris , Paris, France.
  slot:
    index: 15
    item: Pietrement C
      type: Person
      first name: Christine
      last name: Pietrement
      member of: Centre Hospitalier Universitaire de Reims, Service de Pédiatrie Spécialisée et Généralisée, Université Reims Champagne Ardenne , Reims, France.
  slot:
    index: 16
    item: Malphettes M
      type: Person
      first name: Marion
      last name: Malphettes
      member of: Service d'Immunopathologie Clinique, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris , Paris, France.
  slot:
    index: 17
    item: Froissart A
      type: Person
      first name: Antoine
      last name: Froissart
      member of: Service Médecine Interne, Hôpital Intercommunal de Créteil , Créteil, France.
  slot:
    index: 18
    item: Bole-Feysot C
      type: Person
      first name: Christine
      last name: Bole-Feysot
      member of: Genomic Platform, INSERM UMR 1163, Imagine Institute, University Paris Cité , Paris, France.
  slot:
    index: 19
    item: Cagnard N
      type: Person
      first name: Nicolas
      last name: Cagnard
      member of: Bioinformatic Platform, INSERM UMR 1163, Imagine Institute, University Paris Cité , Paris, France.
  slot:
    index: 20
    item: Rodrigues Lima F
      type: Person
      first name: Fernando
      last name: Rodrigues Lima
      member of: Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative , Paris, France.
  slot:
    index: 21
    item: Walzer T
      type: Person
      first name: Thierry
      last name: Walzer
      member of: Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon , Lyon, France.
  slot:
    index: 22
    item: Rieux-Laucat F
      type: Person
      first name: Frédéric
      last name: Rieux-Laucat
      member of: Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, Université Paris Cité, INSERM UMR 1163 , Paris, France, IHU-Imagine, Université de Paris, Paris, France.
  slot:
    index: 23
    item: Belot A
      type: Person
      first name: Alexandre
      last name: Belot
      member of: Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon , Lyon, France.National Referee Centre for Pediatric-Onset Rheumatism and Autoimmune Diseases, Hospices Civils de Lyon, Pediatric Nephrology, Rheumatology, Dermatology Unit, Mother and Children University Hospital ; Lyon, France.
  slot:
    index: 24
    item: Mathieu AL
      type: Person
      first name: Anne-Laure
      last name: Mathieu
      member of: Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon , Lyon, France.
created: 2024-7-19T18:42
date last updated: 2025-01-20
issued: 2024-09-02
dp: 2024 09 02
created: 2024-7-19T14:52
e ISSN: 1540-9538
has issn l: 0022-1007
issue: 9
has NLM journal title abbreviation: J Exp Med
publication name: The Journal of experimental medicine
language: eng
has national library of medicine journal id: 2985109R
derived from: NLM
has place of publication: United States
has primary subject term: D057895Q000235
has primary subject term: D054578Q000235
has primary subject term: D000744Q000235Q000276
has primary subject term: D008180Q000235Q000276
has primary subject term: D015551Q000235
has subject term: D006801
has subject term: D005260
has subject term: D008297
has subject term: D002648
has subject term: D000293
has subject term: D009154
has subject term: D013922Q000235Q000276
has subject term: D000071222Q000235
has subject term: D001323Q000276
has subject term: D016207Q000378
has subject term: D002675
has subject term: D013601Q000276
has subject term: D013921
source: J Exp Med. 2024-09-02;221(9):.
volume: 221

Structural determinants of spike infectivity in bat SARS-like coronaviruses RsSHC014 and WIV1.
pmid: 39028202
abstract: The recurrent spillovers of coronaviruses (CoVs) have posed severe threats to public health and the global economy. Bat severe acute respiratory syndrome (SARS)-like CoVs RsSHC014 and WIV1, currently circulating in bat populations, are poised for human emergence. The trimeric spike (S) glycoprotein, responsible for receptor recognition and membrane fusion, plays a critical role in cross-species transmission and infection. Here, we determined the cryo-electron microscopy (EM) structures of the RsSHC014 S protein in the closed state at 2.9 Å, the WIV1 S protein in the closed state at 2.8 Å, and the intermediate state at 4.0 Å. In the intermediate state, one receptor-binding domain (RBD) is in the down position, while the other two RBDs exhibit poor density. We also resolved the complex structure of the WIV1 S protein bound to human ACE2 (hACE2) at 4.5 Å, which provides structural basis for the future emergence of WIV1 in humans. Through biochemical experiments, we found that despite strong binding affinities between the RBDs and both human and civet ACE2, the pseudoviruses of RsSHC014, but not WIV1, failed to infect 293T cells overexpressing either human or civet ACE2. Mutagenesis analysis revealed that the Y623H substitution, located in the SD2 region, significantly improved the cell entry efficiency of RsSHC014 pseudoviruses, which is likely accomplished by promoting the open conformation of spike glycoproteins. Our findings emphasize the necessity of both efficient RBD lifting and tight RBD-hACE2 binding for viral infection and underscore the significance of the 623 site of the spike glycoprotein for the infectivity of bat SARS-like CoVs.The bat SARS-like CoVs RsSHC014 and WIV1 can use hACE2 for cell entry without further adaptation, indicating their potential risk of emergence in human populations. The S glycoprotein, responsible for receptor recognition and membrane fusion, plays a crucial role in cross-species transmission and infection. In this study, we determ[cell cut: 2603 characters, first 2000 kept]
doi: 10.1128/jvi.00342-24
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Qiao S
      type: Person
      first name: Shuyuan
      last name: Qiao
      member of: The Ministry of Education Key Laboratory of Protein Science, Beijing, China.Beijing Frontier Research Center for Biological Structure, Beijing, China.School of Life Sciences, Tsinghua University, Beijing, China.
  slot:
    index: 2
    item: Wang X
      type: Person
      first name: Xinquan
      last name: Wang
      member of: The Ministry of Education Key Laboratory of Protein Science, Beijing, China.Beijing Frontier Research Center for Biological Structure, Beijing, China.School of Life Sciences, Tsinghua University, Beijing, China.
created: 2024-7-19T12:42
date last updated: 2025-01-20
issued: 2024-08-20
dp: 2024 Aug 20
created: 2024-7-19T09:03
e ISSN: 1098-5514
has issn l: 0022-538X
issue: 8
has NLM journal title abbreviation: J Virol
publication name: Journal of virology
language: eng
has national library of medicine journal id: 0113724
derived from: NLM
pg: e0034224
has place of publication: United States
has primary subject term: D064370Q000378Q000737Q000235
has primary subject term: D002685Q000821
has primary subject term: D020285
has primary subject term: D000085962Q000378Q000737
has subject term: D006801
has subject term: D000818
has subject term: D011485
has subject term: D045473Q000235Q000737Q000378Q000502
has subject term: D053586
has subject term: D008958
has subject term: D011487
has subject term: D057809
source: J Virol. 2024-08-20;98(8):e0034224.
volume: 98

PTPN2 deficiency: Amping up JAK/STAT.
pmid: 39028870
abstract: Identification of monogenic causes of immune dysregulation provides insight into human immune response and signaling pathways associated with autoimmunity. Here, Jeanpierre et al. (https://doi.org/10.1084/jem.20232337) identify new germline variants in the gene encoding PTPN2 associated with loss of regulatory function, enhanced JAK/STAT signaling, and early-onset autoimmunity.
rights: © 2024 Tobin and Cooper.
has PII: 276867
doi: 10.1084/jem.20240980
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Tobin JM
      type: Person
      first name: Joshua M
      last name: Tobin
      member of: Division of Rheumatology/Immunology, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
  slot:
    index: 2
    item: Cooper MA
      type: Person
      first name: Megan A
      last name: Cooper
      member of: Division of Rheumatology/Immunology, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
created: 2024-7-19T18:42
date last updated: 2025-01-20
issued: 2024-09-02
dp: 2024 09 02
created: 2024-7-19T14:52
e ISSN: 1540-9538
has issn l: 0022-1007
issue: 9
has NLM journal title abbreviation: J Exp Med
publication name: The Journal of experimental medicine
language: eng
has national library of medicine journal id: 2985109R
derived from: NLM
has place of publication: United States
has primary subject term: D054578Q000235Q000378
has primary subject term: D015398
has primary subject term: D050791Q000378Q000235
has primary subject term: D053612Q000378Q000235
has subject term: D006801
has subject term: D015551
has subject term: D018095
source: J Exp Med. 2024-09-02;221(9):.
volume: 221

JAAD Game Changers: Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia: A systematic review.
pmid: 39029526
has PII: S0190-9622(24)02502-7
doi: 10.1016/j.jaad.2024.07.1451
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Friedman A
      type: Person
      first name: Adam
      last name: Friedman
created: 2024-7-20T10:44
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2024-7-19T19:28
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
pg: 239
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):239.
volume: 92

JAAD Game Changer: Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients.
pmid: 39029523
has PII: S0190-9622(24)02504-0
doi: 10.1016/j.jaad.2024.07.1453
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Friedman A
      type: Person
      first name: Adam
      last name: Friedman
created: 2024-7-20T10:43
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2024-7-19T19:28
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
pg: 251
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):251.
volume: 92

JAAD Game Changers: Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the US Cutaneous Lymphoma Consortium.
pmid: 39029527
has PII: S0190-9622(24)02503-9
doi: 10.1016/j.jaad.2024.07.1452
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Friedman A
      type: Person
      first name: Adam
      last name: Friedman
created: 2024-7-20T10:44
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2024-7-19T19:28
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
pg: 241
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):241.
volume: 92

JAAD Game Changers: The use of oral antibiotics before isotretinoin therapy in patients with acne.
pmid: 39033979
has PII: S0190-9622(24)02505-2
doi: 10.1016/j.jaad.2024.07.1454
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Friedman A
      type: Person
      first name: Adam
      last name: Friedman
created: 2024-7-22T00:42
date last updated: 2025-01-19
issued: 2025-02
dp: 2025 Feb
created: 2024-7-21T19:25
e ISSN: 1097-6787
has issn l: 0190-9622
issue: 2
has NLM journal title abbreviation: J Am Acad Dermatol
publication name: Journal of the American Academy of Dermatology
language: eng
has national library of medicine journal id: 7907132
derived from: NLM
pg: 310
has place of publication: United States
source: J Am Acad Dermatol. 2025-02;92(2):310.
volume: 92

Practical Strategies for Nurse Leaders to De-Implement Low-Value Nursing Practices.
pmid: 39028988
has PII: 00001786-202501000-00001
doi: 10.1097/NCQ.0000000000000796
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Morris A
      type: Person
      first name: April
      last name: Morris
      member of: Author Affiliation: Duquesne University, Pittsburgh, Pennsylvania.
created: 2024-7-19T18:41
date last updated: 2025-01-20
created: 2024-7-19T16:43
e ISSN: 1550-5065
has issn l: 1057-3631
issue: 1
has NLM journal title abbreviation: J Nurs Care Qual
publication name: Journal of nursing care quality
language: eng
has national library of medicine journal id: 9200672
derived from: NLM
starting page: 1
ending page: 4
has place of publication: United States
source: J Nurs Care Qual. ;40(1):1-4.
volume: 40

What's in a Gas-Brief Guidance for Nursing Educators on the Purpose of Arterial Blood Gas Testing.
pmid: 39028971
has PII: 00001786-202501000-00016
doi: 10.1097/NCQ.0000000000000798
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Istanboulian L
      type: Person
      first name: Laura
      last name: Istanboulian
  slot:
    index: 2
    item: Lee C
      type: Person
      first name: Charlotte
      last name: Lee
created: 2024-7-19T18:42
date last updated: 2025-01-20
created: 2024-7-19T16:33
e ISSN: 1550-5065
has issn l: 1057-3631
issue: 1
has NLM journal title abbreviation: J Nurs Care Qual
publication name: Journal of nursing care quality
language: eng
has national library of medicine journal id: 9200672
derived from: NLM
pg: 14
has place of publication: United States
source: J Nurs Care Qual. ;40(1):14.
volume: 40

What conclusions can (and cannot) be drawn three years after transperineal laser ablation of prostate?
pmid: 39045662
has PII: S2724-6051.24.06008-7
doi: 10.23736/S2724-6051.24.06008-7
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Minafra P
      type: Person
      first name: Paolo
      last name: Minafra
      member of: Unit of Urology, Department of Emergency and Organ Transplantation, Aldo Moro University, Bari, Italy - minafra.p@gmail.com.Unit of Urology, Mater Dei Hospital, Bari, Italy - minafra.p@gmail.com.
  slot:
    index: 2
    item: DE Rienzo G
      type: Person
      first name: Gaetano
      last name: DE Rienzo
      member of: Unit of Urology, Department of Emergency and Organ Transplantation, Aldo Moro University, Bari, Italy.
  slot:
    index: 3
    item: Ditonno P
      type: Person
      first name: Pasquale
      last name: Ditonno
      member of: Unit of Urology, Department of Emergency and Organ Transplantation, Aldo Moro University, Bari, Italy.
created: 2024-7-24T06:41
date last updated: 2025-01-20
issued: 2024-12
dp: 2024 Dec
created: 2024-7-24T04:34
e ISSN: 2724-6442
has issn l: 2724-6051
issue: 6
has NLM journal title abbreviation: Minerva Urol Nephrol
publication name: Minerva urology and nephrology
language: eng
has national library of medicine journal id: 101777299
derived from: NLM
starting page: 804
ending page: 805
has place of publication: Italy
source: Minerva Urol Nephrol. 2024-12;76(6):804-805.
volume: 76

Reinforced colour preference of parasitoid wasps in the presence of floral scent: a case study of a cross-modal effect.
pmid: 39052136
abstract: We examined the possibility of a cross-modal effect in naïve Cotesia vestalis, a parasitoid wasp of diamondback moth larvae, by using artificial flower models of four colours (blue, green, yellow, and red) in the absence or presence of floral scent collected from Brassica rapa inflorescences. In a four-choice test, regardless of the floral scent, non-starved female wasps visited green and yellow models significantly more often than blue and red ones, although no significant difference was observed between visits to the green and yellow models. They seldom visited blue and red models. When starved, the wasps became even more particular, visiting yellow significantly more frequently than green models, irrespective of the presence of the floral scent, indicating that they preferred to use yellow visual cues in their food search. Furthermore, a factorial analysis of variance revealed a significant effect of the interaction between model colour and floral scent on the wasps' visits to flower models. The floral scent induced starved and non-starved wasps to visit yellow and green models about twice as often as without the scent. A cross-modal effect of olfactory perception on the use of chromatic information by wasps may allow them to search efficiently for food sources.
rights: © 2024. The Author(s).
has PII: 10.1007/s10071-024-01890-6
doi: 10.1007/s10071-024-01890-6
creator: OrderedList
  length: 3
  slot:
    index: 1
    item: Kugimiya S
      type: Person
      first name: Soichi
      last name: Kugimiya
      member of: Institute for Plant Protection, National Agriculture and Food Research Organization (NARO), Kannondai 3-1-3, Tsukuba, Ibaraki, 305-8604, Japan. kugimiya@affrc.go.jp.
  slot:
    index: 2
    item: Shimoda T
      type: Person
      first name: Takeshi
      last name: Shimoda
      member of: Institute for Plant Protection, National Agriculture and Food Research Organization (NARO), Kannondai 3-1-3, Tsukuba, Ibaraki, 305-8604, Japan.Tohoku Agricultural Research Center, NARO, Akahira 4, Shimo-kuriyagawa, Morioka, Iwate, 020-0198, Japan.
  slot:
    index: 3
    item: Takabayashi J
      type: Person
      first name: Junji
      last name: Takabayashi
      member of: Center for Ecological Research, Kyoto University, Hirano 2-509-3, Otsu, Shiga, 520-2113, Japan.
created: 2024-7-26T12:41
date last updated: 2025-01-20
issued: 2024-07-25
dp: 2024 Jul 25
created: 2024-7-25T11:16
e ISSN: 1435-9456
has issn l: 1435-9448
issue: 1
has NLM journal title abbreviation: Anim Cogn
publication name: Animal cognition
language: eng
has national library of medicine journal id: 9814573
derived from: NLM
pg: 50
has place of publication: Germany
has primary subject term: D014863Q000502
has primary subject term: D009812
has primary subject term: D035264
has primary subject term: D003118
has subject term: D000818
has subject term: D005260
has subject term: D003463
has subject term: D002755
has subject term: D009036Q000469
has subject term: D055696
has subject term: D003116
source: Anim Cogn. 2024-07-25;27(1):50.
volume: 27

Lattice matching enables construction of CaS@NaYF4 heterostructure with synergistically enhanced water resistance and luminescence for antibiotic detection.
pmid: 39060720
abstract: Rare earth (RE)-doped CaS phosphors have been widely used as light-emitting components in various fields. Nevertheless, the application of nanosized CaS particles is still significantly limited by their poor water resistance and weak luminescence. Herein, a lattice-matching strategy is developed by growing an inert shell of cubic NaYF4 phase on the CaS luminescent core. Due to their similarity in crystal structure, a uniform core-shell heterostructure (CaS:Ce3+@NaYF4) can be obtained, which effectively protects the CaS:Ce3+ core from degradation in aqueous environment and enhances its luminescence intensity. As a proof of concept, a label-free aptasensor is further constructed by combining core-shell CaS:Ce3+@NaYF4 and Au nanoparticles (AuNPs) for the ultrasensitive detection of kanamycin antibiotics. Based on the efficient FRET process, the detection linear range of kanamycin spans from 100 to 1000 nM with a detection limit of 7.8 nM. Besides, the aptasensor shows excellent selectivity towards kanamycin antibiotics, and has been successfully applied to the detection of kanamycin spiked in tap water and milk samples, demonstrating its high potential for sensing applications.
rights: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
has PII: 10.1007/s00604-024-06568-x
doi: 10.1007/s00604-024-06568-x
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Wang Y
      type: Person
      first name: Yao
      last name: Wang
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
  slot:
    index: 2
    item: Chen H
      type: Person
      first name: Huadong
      last name: Chen
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
  slot:
    index: 3
    item: Zhao T
      type: Person
      first name: Tonghan
      last name: Zhao
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
  slot:
    index: 4
    item: Wang J
      type: Person
      first name: Jing
      last name: Wang
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
  slot:
    index: 5
    item: Wu Y
      type: Person
      first name: Yihan
      last name: Wu
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
  slot:
    index: 6
    item: Liu J
      type: Person
      first name: Jinliang
      last name: Liu
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
  slot:
    index: 7
    item: Zhang Y
      type: Person
      first name: Yong
      last name: Zhang
      member of: Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China. yozhang@cityu.edu.hk.
  slot:
    index: 8
    item: Zhu X
      type: Person
      first name: Xiaohui
      last name: Zhu
      member of: School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. xhzhu@shu.edu.cn.
created: 2024-7-27T10:42
date last updated: 2025-01-20
issued: 2024-07-26
dp: 2024 07 26
created: 2024-7-26T23:38
e ISSN: 1436-5073
has issn l: 0026-3672
issue: 8
has NLM journal title abbreviation: Mikrochim Acta
publication name: Mikrochimica acta
language: eng
has national library of medicine journal id: 7808782
derived from: NLM
pg: 485
has place of publication: Austria
has primary subject term: D005459Q000737
has primary subject term: D000900Q000032Q000737
has primary subject term: D008892Q000737
has primary subject term: D015019Q000737
has primary subject term: D006046Q000737
has primary subject term: D053768Q000737
has primary subject term: D007612Q000032Q000737
has primary subject term: D057230
has subject term: D052157Q000737
has subject term: D000818
has subject term: D014874Q000032
has subject term: D049449
has subject term: D060766Q000032
has subject term: D015374Q000379
has subject term: D014867Q000737
has subject term: D031541Q000379
source: Mikrochim Acta. 2024-07-26;191(8):485.
volume: 191

Retraction Note: Importance of Religious Coping in Bereaved Parents after the Death of a Child with Genetic Disorder.
pmid: 39086441
abstract: An investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Genetics in Volume 12, Number 02, 95-96, in June 2023 (DOI: 10.1055/s-0042-1759781), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
rights: Thieme. All rights reserved.
has PII: JPG-D-22-00023_Retraction Note
doi: 10.1055/s-0044-1779450
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Çaksen H
      type: Person
      first name: Hüseyin
      last name: Çaksen
      member of: Divisions of Pediatric Neurology and Genetics and Behavioral-Developmental Pediatrics, Department of Pediatrics, Meram Medical Faculty, Necmettin Erbakan University, Meram, Konya, Türkiye.
created: 2024-8-1T06:41
date last updated: 2025-01-20
issued: 2024-09
dp: 2024 09
created: 2024-8-1T04:14
ISSN: 2146-4596
has issn l: 2146-460X
issue: 3
has NLM journal title abbreviation: J Pediatr Genet
publication name: Journal of pediatric genetics
language: eng
has national library of medicine journal id: 101589859
derived from: NLM
pg: 250
has place of publication: Germany
source: J Pediatr Genet. 2024-09;13(3):250.
volume: 13

Retraction Note: A Brief View of The Prophet Ayyub's (Alayhi As-Salam) Disease: Was It Job's Syndrome?
pmid: 39086448
abstract: An investigation by the publisher found a number of articles, including this one, published in Journal of Pediatric Genetics in Volume 12, Number 03, 185-186, in September 2023 (DOI: 10.1055/s-0043-1764300), with a number of concerns, including but not limited to undeclared conflicts of interest and manipulated peer review procedures. As a result, the publisher has retracted and removed this article.
rights: Thieme. All rights reserved.
has PII: JPG-D-22-00017RetractionNote
doi: 10.1055/s-0044-1779461
creator: OrderedList
  length: 1
  slot:
    index: 1
    item: Çaksen H
      type: Person
      first name: Hüseyin
      last name: Çaksen
      member of: Divisions of Pediatric Neurology and Genetics and Behavioral-Developmental Pediatrics, Department of Pediatrics, Meram Medical Faculty, Necmettin Erbakan University, Meram, Konya, Türkiye.
created: 2024-8-1T06:42
date last updated: 2025-01-20
issued: 2024-09
dp: 2024 09
created: 2024-8-1T04:14
ISSN: 2146-4596
has issn l: 2146-460X
issue: 3
has NLM journal title abbreviation: J Pediatr Genet
publication name: Journal of pediatric genetics
language: eng
has national library of medicine journal id: 101589859
derived from: NLM
pg: 252
has place of publication: Germany
source: J Pediatr Genet. 2024-09;13(3):252.
volume: 13

Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies.
pmid: 39108718
abstract: Ribosomopathies arise from the disruptions in ribosome biogenesis within the nucleolus, which is organized via liquid-liquid phase separation (LLPS). The roles of LLPS in ribosomopathies remain poorly understood. Here, we generated human induced pluripotent stem cell (hiPSC) models of ribosomopathy caused by mutations in small nucleolar RNA (snoRNA) gene SNORD118. Mutant hiPSC-derived neural progenitor cells (NPCs) or neural crest cells (NCCs) exhibited ribosomopathy hallmark cellular defects resulting in reduced organoid growth, recapitulating developmental delay in patients. SNORD118 mutations in NPCs disrupted nucleolar morphology and LLPS properties coupled with impaired ribosome biogenesis and a translational downregulation of fibrillarin (FBL), the key LLPS effector acting via the intrinsically disordered region (IDR) motif. IDR-depleted FBL failed to rescue NPC defects, whereas a chimeric FBL with swapped IDR motif from an unrelated protein mitigated ribosomopathy and organoid growth defects. Thus, SNORD118 human iPSC models revealed aberrant phase separation and nucleolar functions as potential pathogenic mechanisms in ribosomopathies.
has PII: S2589-0042(24)01655-9
doi: 10.1016/j.isci.2024.110430
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Zhang W
      type: Person
      first name: Wei
      last name: Zhang
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
  slot:
    index: 2
    item: Zhang M
      type: Person
      first name: Minjie
      last name: Zhang
      member of: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  slot:
    index: 3
    item: Ma L
      type: Person
      first name: Li
      last name: Ma
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
  slot:
    index: 4
    item: Jariyasakulroj S
      type: Person
      first name: Supawadee
      last name: Jariyasakulroj
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
  slot:
    index: 5
    item: Chang Q
      type: Person
      first name: Qing
      last name: Chang
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
  slot:
    index: 6
    item: Lin Z
      type: Person
      first name: Ziying
      last name: Lin
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
  slot:
    index: 7
    item: Lu Z
      type: Person
      first name: Zhipeng
      last name: Lu
      member of: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  slot:
    index: 8
    item: Chen JF
      type: Person
      first name: Jian-Fu
      last name: Chen
      member of: Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
created: 2024-8-7T06:41
date last updated: 2025-01-20
issued: 2024-08-16
dp: 2024 Aug 16
created: 2024-8-7T04:30
e ISSN: 2589-0042
has issn l: 2589-0042
issue: 8
has NLM journal title abbreviation: iScience
publication name: iScience
language: eng
has national library of medicine journal id: 101724038
derived from: NLM
pg: 110430
has place of publication: United States
source: iScience. 2024-08-16;27(8):110430.
volume: 27

Clustering-triggered emission mechanism of carboxymethyl β-cyclodextrin aqueous solution and efficient recognition of Fe3+ in mixed ions.
pmid: 39129424
abstract: Most nonconventional luminogens enjoy good water solubility and biocompatibility, showing unique application prospects in fields like biological imaging. Although clustering-triggered emission (CTE) mechanisms have been proposed to explain such emissions, the have not been thoroughly elucidated, which limits their development and application. Here, the photoluminescence properties of carboxymethyl β-cyclodextrin (CM-β-CD) aqueous solution are utilized to further investigate the effects of changes in concentration, in order to elucidate the emission mechanism through cryo-transmission electron microscopy (cryo-TEM), small-angle X-ray scattering (SAXS), molecular interaction analysis, and theoretical calculation. The results showed that the size distribution, morphology, and distance between water aggregates were successfully correlated with the cluster emission centers. The emission mechanism of nonconventional luminogen solutions was more clearly and intuitively elucidated, which has a promoting effect on the emission and application of this field. It is interesting that temperature-dependent emission spectra show the blue-shift phenomenon of PL with increasing excitation wavelengths. Moreover, due to its strong static quenching effect for Fe3+, CM-β-CD can efficiently detect Fe3+ in mixed-ion aqueous solutions. It provides a strategy to clarify the CTE mechanism of nonconventional luminogen solutions more clearly and its application of mixed-ion detection.
rights: © 2024 John Wiley & Sons Ltd.
doi: 10.1002/bio.4856
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Xu H
      type: Person
      first name: Haiyan
      last name: Xu
      member of: Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou, China.
  slot:
    index: 2
    item: Wang J
      type: Person
      first name: Jun
      last name: Wang
      member of: Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou, China.
  slot:
    index: 3
    item: Li Q
      type: Person
      first name: Qi
      last name: Li
      member of: Zhejiang Sci-Tech University Shaoxing-Keqiao Research Institute, Zhejiang Provincial Innovation Center of Advanced Textile Technology, Building 7, Cross border E-commerce Park, Huashe Street, Keqiao District, Shaoxing City, Zhejiang, China.
  slot:
    index: 4
    item: Zhou Q
      type: Person
      first name: Qing
      last name: Zhou
      member of: Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou, China.Zhejiang Sci-Tech University Shaoxing-Keqiao Research Institute, Zhejiang Provincial Innovation Center of Advanced Textile Technology, Building 7, Cross border E-commerce Park, Huashe Street, Keqiao District, Shaoxing City, Zhejiang, China.MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
created: 2024-8-12T06:43
date last updated: 2025-01-20
issued: 2024-08
dp: 2024 Aug
created: 2024-8-12T03:22
e ISSN: 1522-7243
has issn l: 1522-7235
issue: 8
has NLM journal title abbreviation: Luminescence
publication name: Luminescence : the journal of biological and chemical luminescence
language: eng
has national library of medicine journal id: 100889025
derived from: NLM
pg: e4856
has place of publication: England
has primary subject term: D047392Q000737
has primary subject term: D014867Q000737
has subject term: D049449
has subject term: D007477Q000737
has subject term: D012996
has subject term: D014961
has subject term: D053838
has subject term: D015394
has subject term: D005290Q000737
source: Luminescence. 2024-08;39(8):e4856.
volume: 39

The effects of the space environment on circadian rhythm and sleep in astronauts: An emphasis on the telomere length dynamics associated with sleep.
pmid: 39137932
doi: 10.1111/jsr.14312
creator: OrderedList
  length: 4
  slot:
    index: 1
    item: Xerfan EMS
      type: Person
      first name: Ellen M S
      last name: Xerfan
      member of: Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
  slot:
    index: 2
    item: Tempaku PF
      type: Person
      first name: Priscila F
      last name: Tempaku
      member of: Sleep Institute, Associação Fundo de Incentivo à Pesquisa (AFIP), São Paulo, Brazil.
  slot:
    index: 3
    item: Tufik S
      type: Person
      first name: Sergio
      last name: Tufik
      member of: Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.Sleep Institute, Associação Fundo de Incentivo à Pesquisa (AFIP), São Paulo, Brazil.
  slot:
    index: 4
    item: Andersen ML
      type: Person
      first name: Monica L
      last name: Andersen
      member of: Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.Sleep Institute, Associação Fundo de Incentivo à Pesquisa (AFIP), São Paulo, Brazil.
created: 2024-8-14T00:42
date last updated: 2025-01-20
issued: 2025-02
dp: 2025 Feb
created: 2024-8-13T20:22
e ISSN: 1365-2869
has issn l: 0962-1105
issue: 1
has NLM journal title abbreviation: J Sleep Res
publication name: Journal of sleep research
language: eng
has national library of medicine journal id: 9214441
derived from: NLM
pg: e14312
has place of publication: England
source: J Sleep Res. 2025-02;34(1):e14312.
volume: 34

Risk Factors of Alcohol Use Disorders Among Inpatients with Schizophrenia: An Institutional-Based Cross-sectional Survey.
pmid: 39148606
abstract: This study aimed to elucidate the risk factors associated with alcohol use disorders (AUDs) among inpatients with schizophrenia at a specialized mental hospital in Baoding city, China.This cross-sectional survey comprised 301 comorbid patients. Three binary logistic regression models were used to investigate the factors linked to AUDs in patients with schizophrenia. Propensity score matching analysis was conducted to validate inconsistent variables identified by the regression models.Significant differences were observed between the comorbid and non-comorbid groups concerning sex (P < .001), disposition (P = .049), smoking habits (P < .001), place of residence (P = .010), family relationships (P = .002), family history of mental disorders (P = .008), history of alcoholism (P = .003), onset latency (P = .005), impulsivity (P < .001), suicide or self-injury history (P < .001), and obvious aggressive behavior (P < .001) in univariate analyses. The area under the curve values for the three regression models were 0.83 (P < .001), 0.80 (P < .001), and 0.81 (P < .001), respectively. Binary logistic regression and propensity score matching analyses indicated that introverted disposition, smoking, acute onset, impulsivity, and suicide or self-injury history were independent risk factors associated with AUDs in inpatients with schizophrenia with an odds ratio of > 1.Introverted disposition, smoking, acute onset, impulsivity, and suicide or self-injury history were independently associated with the AUDs in inpatients with schizophrenia. Future studies should prioritize longitudinal studies to discern the evolving dynamics of potential confounding risk factors.
rights: 2024 authors.
has PII: ap-25-3-421
doi: 10.5152/alphapsychiatry.2024.241613
creator: OrderedList
  length: 8
  slot:
    index: 1
    item: Li B
      type: Person
      first name: Bing
      last name: Li
      member of: Hebei Provincial Mental Health Center, Baoding, China.Hebei Key Laboratory of Major Mental and Behavioral Disorders, Baoding, China.The Sixth Clinical Medical College of Hebei University, Baoding, China.
  slot:
    index: 2
    item: Li W
      type: Person
      first name: Wei
      last name: Li
      member of: Hebei Provincial Mental Health Center, Baoding, China.Hebei Key Laboratory of Major Mental and Behavioral Disorders, Baoding, China.The Sixth Clinical Medical College of Hebei University, Baoding, China.
  slot:
    index: 3
    item: Wang J
      type: Person
      first name: Jie
      last name: Wang
      member of: Hebei Provincial Mental Health Center, Baoding, China.Hebei Key Laboratory of Major Mental and Behavioral Disorders, Baoding, China.The Sixth Clinical Medical College of Hebei University, Baoding, China.
  slot:
    index: 4
    item: Zhang X
      type: Person
      first name: Xianfeng
      last name: Zhang
      member of: Hebei Provincial Mental Health Center, Baoding, China.Hebei Key Laboratory of Major Mental and Behavioral Disorders, Baoding, China.The Sixth Clinical Medical College of Hebei University, Baoding, China.
  slot:
    index: 5
    item: Zheng W
      type: Person
      first name: Wei
      last name: Zheng
      member of: Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
  slot:
    index: 6
    item: Liu C
      type: Person
      first name: Chaomeng
      last name: Liu
      member of: Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
  slot:
    index: 7
    item: Yan B
      type: Person
      first name: Baoping
      last name: Yan
      member of: Hebei Provincial Mental Health Center, Baoding, China.Hebei Key Laboratory of Major Mental and Behavioral Disorders, Baoding, China.The Sixth Clinical Medical College of Hebei University, Baoding, China.
  slot:
    index: 8
    item: Chen X
      type: Person
      first name: Xueyan
      last name: Chen
      member of: Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
created: 2024-8-16T06:42
date last updated: 2025-01-20
issued: 2024-06
dp: 2024 Jun
created: 2024-8-16T04:25
e ISSN: 2757-8038
has issn l: 2757-8038
issue: 3
has NLM journal title abbreviation: Alpha Psychiatry
publication name: Alpha psychiatry
language: eng
has national library of medicine journal id: 9918284277106676
derived from: NLM
starting page: 421
ending page: 428
has place of publication: Turkey
source: Alpha Psychiatry. 2024-06;25(3):421-428.
volume: 25

Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cells.
pmid: 39211250
abstract: Immune-surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell-mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a novel function for intracellular C3d, we discovered that C3d engaged T cell responses against malignant plasma cells in the bone marrow of mice that had developed multiple myeloma spontaneously. Our results show that C3d internalized by cells augments immune surveillance by several mechanisms. In one, C3d induces a master transcription regulator, E2f1, to increase the expression of long non-coding (lnc) RNAs, to generate peptides for MHC-I presentation and increase MHC-I expression. In another, C3d increases expression of RNAs encoding ribosomal proteins linked to processing of defective ribosomal products (DRiPs) that arise from non-canonical translation and known to promote immunosurveillance. Cancer cells are uniquely susceptible to increased expression and presentation of mutant peptides given the extent of protein misfolding and accumulation of somatic mutations. Accordingly, although C3d can be internalized by any cell, C3d preferentially targets malignant clones by evoking specific T cell mediated immunity (CMI) and sparing most non-transformed polyclonal B cells and plasma cells with lower mutation loads. Malignant plasma cell deletion was blocked by cyclosporin or by CD8 depletion confirming that endogenous T cells mediated malignant clone clearance. Besides the potential for therapeutic application our results highlight how intracellular C3d modifies cellular metabolism to augment immune surveillance.We show that intracellular soluble fragment 3d of complement (C3d) induces regression of spontaneous multiple myeloma in mice reducing tumor burden by 10 fold, after 8 weeks. C3d enables cell-mediated immunity[cell cut: 3181 characters, first 2000 kept]
doi: 10.1101/2024.07.31.606044
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      type: Person
      first name: Jeffrey L
      last name: Platt
  slot:
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    item: Zhao C
      type: Person
      first name: Chong
      last name: Zhao
  slot:
    index: 3
    item: Chicca J
      type: Person
      first name: Jeffrey
      last name: Chicca
  slot:
    index: 4
    item: Pianko MJ
      type: Person
      first name: Matthew J
      last name: Pianko
  slot:
    index: 5
    item: Han J
      type: Person
      first name: Joshua
      last name: Han
  slot:
    index: 6
    item: The S
      type: Person
      first name: Stephanie
      last name: The
  slot:
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    item: Rao A
      type: Person
      first name: Arvind
      last name: Rao
  slot:
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    item: Keller E
      type: Person
      first name: Evan
      last name: Keller
  slot:
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    item: de Mattos Barbosa MG
      type: Person
      first name: Mayara Garcia
      last name: de Mattos Barbosa
  slot:
    index: 10
    item: Naing L
      type: Person
      first name: Lwar
      last name: Naing
  slot:
    index: 11
    item: Pasieka-Axenov T
      type: Person
      first name: Tracy
      last name: Pasieka-Axenov
  slot:
    index: 12
    item: Axenov L
      type: Person
      first name: Lev
      last name: Axenov
  slot:
    index: 13
    item: Schaefer S
      type: Person
      first name: Simon
      last name: Schaefer
  slot:
    index: 14
    item: Farkash E
      type: Person
      first name: Evan
      last name: Farkash
  slot:
    index: 15
    item: Cascalho M
      type: Person
      first name: Marilia
      last name: Cascalho
created: 2024-8-31T09:44
date last updated: 2025-01-20
issued: 2024-07-31
dp: 2024 Jul 31
created: 2024-8-30T04:21
e ISSN: 2692-8205
has issn l: 2692-8205
has NLM journal title abbreviation: bioRxiv
publication name: bioRxiv : the preprint server for biology
language: eng
has national library of medicine journal id: 101680187
derived from: NLM
has place of publication: United States
source: bioRxiv. 2024-07-31;():.

Definition: Mirror writing.
pmid: 39214714
has PII: S0010-9452(24)00224-7
doi: 10.1016/j.cortex.2024.07.017
creator: OrderedList
  length: 2
  slot:
    index: 1
    item: Fischer JP
      type: Person
      first name: Jean-Paul
      last name: Fischer
      member of: Université de Lorraine, Nancy, France. Electronic address: jean-paul.fischer@univ-lorraine.fr.
  slot:
    index: 2
    item: McIntosh RD
      type: Person
      first name: Robert D
      last name: McIntosh
      member of: University of Edinburgh, Human Cognitive Neuroscience, Psychology, UK. Electronic address: r.d.mcintosh@ed.ac.uk.
created: 2024-8-31T09:52
date last updated: 2025-01-19
issued: 2025-01
dp: 2025 Jan
created: 2024-8-30T21:57
e ISSN: 1973-8102
has issn l: 0010-9452
has NLM journal title abbreviation: Cortex
publication name: Cortex; a journal devoted to the study of the nervous system and behavior
language: eng
has national library of medicine journal id: 0100725
derived from: NLM
starting page: 214
ending page: 215
has place of publication: Italy
source: Cortex. 2025-01;182():214-215.
volume: 182

Correction to: Welldeveloped spatial reversal learning abilities in harbor seals (Phoca vitulina) : Issue : 25_5_Issue.
pmid: 39212805
has PII: 10.1007/s10071-024-01893-3
doi: 10.1007/s10071-024-01893-3
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Niesterok B
      type: Person
      first name: Benedikt
      last name: Niesterok
      member of: Institute for Biosciences, Sensory and Cognitive Ecology, University of Rostock, Albert-Einstein-Str. 3, Rostock, 18059, Germany.
  slot:
    index: 2
    item: Martin S
      type: Person
      first name: Shanie
      last name: Martin
      member of: Faculty of Science and Engineering, Biological and Marine Science, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK.
  slot:
    index: 3
    item: Hildebrand L
      type: Person
      first name: Lisa
      last name: Hildebrand
      member of: Geospatial Ecology of Marine Megafauna Lab, Marine Mammal Institute, and Department of Fisheries, Wildlife and Conservation Sciences, Oregon State University, Newport, OR, 97365, USA.
  slot:
    index: 4
    item: Dehnhardt G
      type: Person
      first name: Guido
      last name: Dehnhardt
      member of: Institute for Biosciences, Sensory and Cognitive Ecology, University of Rostock, Albert-Einstein-Str. 3, Rostock, 18059, Germany.
  slot:
    index: 5
    item: Hanke FD
      type: Person
      first name: Frederike D
      last name: Hanke
      member of: Institute for Biosciences, Sensory and Cognitive Ecology, University of Rostock, Albert-Einstein-Str. 3, Rostock, 18059, Germany. frederike.hanke@uni-rostock.de.
created: 2024-8-31T09:46
date last updated: 2025-01-20
issued: 2024-08-30
dp: 2024 Aug 30
created: 2024-8-30T11:18
e ISSN: 1435-9456
has issn l: 1435-9448
issue: 1
has NLM journal title abbreviation: Anim Cogn
publication name: Animal cognition
language: eng
has national library of medicine journal id: 9814573
derived from: NLM
pg: 59
has place of publication: Germany
source: Anim Cogn. 2024-08-30;27(1):59.
volume: 27

Definition: Aphantasia.
pmid: 39227264
has PII: S0010-9452(24)00223-5
doi: 10.1016/j.cortex.2024.07.019
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Zeman A
      type: Person
      first name: Adam
      last name: Zeman
      member of: Centre for Clinical Brain Sciences, University of Edinburgh, UK; Health & Community Sciences, University of Exeter, UK. Electronic address: a.zeman@exeter.ac.uk.
  slot:
    index: 2
    item: Monzel M
      type: Person
      first name: Merlin
      last name: Monzel
      member of: Department of Psychology, University of Bonn, Germany.
  slot:
    index: 3
    item: Pearson J
      type: Person
      first name: Joel
      last name: Pearson
      member of: School of Psychology, University of New South Wales, Sydney, Australia.
  slot:
    index: 4
    item: Scholz CO
      type: Person
      first name: Christian O
      last name: Scholz
      member of: Institute of Philosophy II, Ruhr-Universität Bochum, Germany.
  slot:
    index: 5
    item: Simner J
      type: Person
      first name: Julia
      last name: Simner
      member of: School of Psychology, University of Sussex, UK.
created: 2024-9-4T01:01
date last updated: 2025-01-19
issued: 2025-01
dp: 2025 Jan
created: 2024-9-3T21:59
e ISSN: 1973-8102
has issn l: 0010-9452
has NLM journal title abbreviation: Cortex
publication name: Cortex; a journal devoted to the study of the nervous system and behavior
language: eng
has national library of medicine journal id: 0100725
derived from: NLM
starting page: 212
ending page: 213
has place of publication: Italy
source: Cortex. 2025-01;182():212-213.
volume: 182

Sleep diaries and other subjective measures are essential for the assessment of insomnia.
pmid: 39231509
doi: 10.1111/jsr.14313
creator: OrderedList
  length: 5
  slot:
    index: 1
    item: Perlis M
      type: Person
      first name: Michael
      last name: Perlis
      member of: Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
created: 2024-9-5T00:50
date last updated: 2025-01-20
issued: 2025-02
dp: 2025 Feb
created: 2024-9-4T19:42
e ISSN: 1365-2869
has issn l: 0962-1105
issue: 1
has NLM journal title abbreviation: J Sleep Res
publication name: Journal of sleep research
language: eng
has national library of medicine journal id: 9214441
derived from: NLM
pg: e14313
has place of publication: England
source: J Sleep Res. 2025-02;34(1):e14313.
volume: 34

index: 29
item: Nettekoven G
  type: Person
  first name: Gerd
  last name: Nettekoven
  member of: German Cancer Aid, Bonn, Germany.

index: 30
item: Baumann M
  type: Person
  first name: Michael
  last name: Baumann
  member of: German Cancer Research Center (DKFZ), Heidelberg, Germany.

index: 29
item: Stern RA
  type: Person
  first name: Robert A
  last name: Stern
  member of: Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.

index: 30
item: Reiman EM
  type: Person
  first name: Eric M
  last name: Reiman
  member of: Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.University of Arizona, Arizona State University, Translational Genomics Research Institute, Phoenix, Arizona, USA.

index: 29
item: Stroh N
  type: Person
  first name: Nico
  last name: Stroh
  member of: Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

index: 30
item: Gmeiner M
  type: Person
  first name: Matthias
  last name: Gmeiner
  member of: Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

index: 31
item: Gruber A
  type: Person
  first name: Andreas
  last name: Gruber
  member of: Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University, Linz, Austria.

index: 32
item: Figueiredo EG
  type: Person
  first name: Eberval G
  last name: Figueiredo
  member of: Division of Neurological Surgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

index: 33
item: Coelho ACSDS
  type: Person
  first name: Antonio Carlos Samaia da Silva
  last name: Coelho
  member of: Division of Neurological Surgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

index: 34
item: Bervitskiy AV
  type: Person
  first name: Anatoliy V
  last name: Bervitskiy
  member of: Federal Center of Neurosurgery, Novosibirsk, Russia.

index: 35
item: Anisimov ED
  type: Person
  first name: Egor D
  last name: Anisimov
  member of: Federal Center of Neurosurgery, Novosibirsk, Russia.

index: 36
item: Rzaev JA
  type: Person
  first name: Jamil A
  last name: Rzaev
  member of: Federal Center of Neurosurgery, Novosibirsk, Russia.

index: 37
item: Krenzlin H
  type: Person
  first name: Harald
  last name: Krenzlin
  member of: Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.

index: 38
item: Keric N
  type: Person
  first name: Naureen
  last name: Keric
  member of: Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.

index: 39
item: Ringel F
  type: Person
  first name: Florian
  last name: Ringel
  member of: Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany.

index: 40
item: Park D
  type: Person
  first name: Dougho
  last name: Park
  member of: Department of Neurosurgery, Pohang Stroke and Spine Hospital, Pohang, Korea.

index: 41
item: Kim MC
  type: Person
  first name: Mun-Chul
  last name: Kim
  member of: Department of Neurosurgery, Pohang Stroke and Spine Hospital, Pohang, Korea.

index: 42
item: Marcati E
  type: Person
  first name: Eleonora
  last name: Marcati
  member of: Department of Neurosurgery, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

index: 43
item: Cenzato M
  type: Person
  first name: Marco
  last name: Cenzato
  member of: Department of Neurosurgery, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

index: 44
item: Krause L
  type: Person
  first name: Linda
  last name: Krause
  member of: Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

index: 45
item: Westphal M
  type: Person
  first name: Manfred
  last name: Westphal
  member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

index: 46
item: Dührsen L
  type: Person
  first name: Lasse
  last name: Dührsen
  member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

index: 47
item: Sauvigny T
  type: Person
  first name: Thomas
  last name: Sauvigny
  member of: Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

index: 29
item: Yue F
  type: Person
  first name: Feng
  last name: Yue
  member of: Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: yue@northwestern.edu.

index: 30
item: Costello JF
  type: Person
  first name: Joseph F
  last name: Costello
  member of: Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: joseph.costello@ucsf.edu.

index: 29
item: Berman SB
  type: Person
  first name: Sarah B
  last name: Berman
  member of: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

index: 30
item: Brooks WS
  type: Person
  first name: William S
  last name: Brooks
  member of: Neuroscience Research Australia, Sydney, NSW, Australia.University of New South Wales, Sydney, NSW, Australia.

index: 31
item: Cash DM
  type: Person
  first name: David M
  last name: Cash
  member of: UK Dementia Research Institute and Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.

index: 32
item: Day GS
  type: Person
  first name: Gregory S
  last name: Day
  member of: Mayo Clinic, Jacksonville, Florida, USA.

index: 33
item: Fox NC
  type: Person
  first name: Nick C
  last name: Fox
  member of: UK Dementia Research Institute and Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.

index: 34
item: Fulham M
  type: Person
  first name: Michael
  last name: Fulham
  member of: Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

index: 35
item: Ghetti B
  type: Person
  first name: Bernardino
  last name: Ghetti
  member of: Indiana University School of Medicine, Indianapolis, Indiana, USA.

index: 36
item: Johnson KA
  type: Person
  first name: Keith A
  last name: Johnson
  member of: Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

index: 37
item: Jucker M
  type: Person
  first name: Mathias
  last name: Jucker
  member of: German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

index: 38
item: Klunk WE
  type: Person
  first name: William E
  last name: Klunk
  member of: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

index: 39
item: la Fougère C
  type: Person
  first name: Christian
  last name: la Fougère
  member of: German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.University hospital Tübingen, Tübingen, Germany.

index: 40
item: Levin J
  type: Person
  first name: Johannes
  last name: Levin
  member of: German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.Ludwig Maximilian University of Munich, Munich, Germany.Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

index: 41
item: Niimi Y
  type: Person
  first name: Yoshiki
  last name: Niimi
  member of: The University of Tokyo, Bunkyo City, Tokyo, Japan.

index: 42
item: Oh H
  type: Person
  first name: Hwamee
  last name: Oh
  member of: Brown University, Providence, Rhode Island, USA.

index: 43
item: Perrin RJ
  type: Person
  first name: Richard J
  last name: Perrin
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 44
item: Reischl G
  type: Person
  first name: Gerald
  last name: Reischl
  member of: German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.University hospital Tübingen, Tübingen, Germany.

index: 45
item: Ringman JM
  type: Person
  first name: John M
  last name: Ringman
  member of: Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

index: 46
item: Saykin AJ
  type: Person
  first name: Andrew J
  last name: Saykin
  member of: Indiana University School of Medicine, Indianapolis, Indiana, USA.

index: 47
item: Schofield PR
  type: Person
  first name: Peter R
  last name: Schofield
  member of: Neuroscience Research Australia, Sydney, NSW, Australia.University of New South Wales, Sydney, NSW, Australia.

index: 48
item: Su Y
  type: Person
  first name: Yi
  last name: Su
  member of: Banner Alzheimer Institute, Banner Health, Phoenix, Arizona, USA.

index: 49
item: Supnet-Bell C
  type: Person
  first name: Charlene
  last name: Supnet-Bell
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 50
item: Vöglein J
  type: Person
  first name: Jonathan
  last name: Vöglein
  member of: German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.Ludwig Maximilian University of Munich, Munich, Germany.

index: 51
item: Yakushev I
  type: Person
  first name: Igor
  last name: Yakushev
  member of: Department of Nuclear Medicine, Technical University of Munich, Munich, Germany.

index: 52
item: Brickman AM
  type: Person
  first name: Adam M
  last name: Brickman
  member of: Columbia University Medical Center, New York, New York, USA.

index: 53
item: Morris JC
  type: Person
  first name: John C
  last name: Morris
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 54
item: McDade E
  type: Person
  first name: Eric
  last name: McDade
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 55
item: Xiong C
  type: Person
  first name: Chengjie
  last name: Xiong
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 56
item: Bateman RJ
  type: Person
  first name: Randall J
  last name: Bateman
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 57
item: Chhatwal JP
  type: Person
  first name: Jasmeer P
  last name: Chhatwal
  member of: Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

index: 58
item: Benzinger TLS
  type: Person
  first name: Tammie L S
  last name: Benzinger
  member of: Washington University School of Medicine in Saint Louis, St. Louis, Missouri, USA.

index: 29
item: Yang H
  type: Person
  first name: Hui
  last name: Yang
  member of: The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.

index: 30
item: Jia Y
  type: Person
  first name: Yuming
  last name: Jia
  member of: Yibin Second People's Hospital, Yibin, China.

index: 31
item: Chen Y
  type: Person
  first name: Yuan
  last name: Chen
  member of: Tongji Hospital of Tongji Medical College of Hust, Wuhan, China.

index: 32
item: Lu J
  type: Person
  first name: Junguo
  last name: Lu
  member of: Nantong Tumor Hospital, Nantong, China.

index: 33
item: Feng J
  type: Person
  first name: Jifeng
  last name: Feng
  member of: Jiangsu Cancer Hospital, Nanjing, China.

index: 34
item: Liu C
  type: Person
  first name: Chunling
  last name: Liu
  member of: Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

index: 35
item: Zhou M
  type: Person
  first name: Ming
  last name: Zhou
  member of: Affiliated Cancer Hospital and Institution of Guangzhou Medical University, Guangzhou, China.

index: 36
item: Zhou J
  type: Person
  first name: Jianya
  last name: Zhou
  member of: The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

index: 37
item: Liu X
  type: Person
  first name: Xianling
  last name: Liu
  member of: The Second Xiangya Hospital of Central South University, Changsha, China.

index: 38
item: Zhou N
  type: Person
  first name: Ningning
  last name: Zhou
  member of: Sun Yat-sen University Cancer Center, Guangzhou, China.

index: 39
item: He M
  type: Person
  first name: Ming
  last name: He
  member of: The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

index: 40
item: Dong X
  type: Person
  first name: Xiaorong
  last name: Dong
  member of: Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.

index: 41
item: Chen H
  type: Person
  first name: Hualin
  last name: Chen
  member of: Affiliated Hospital of Guangdong Medical University, Guangzhou, China.

index: 42
item: Chen Y
  type: Person
  first name: Yongxing
  last name: Chen
  member of: Hainan General Hospital, Haikou, China.

index: 43
item: Su H
  type: Person
  first name: Haichuan
  last name: Su
  member of: Tangdu Hospital of the Fourth Military Medical University, Xi'an, China.

index: 44
item: Li X
  type: Person
  first name: Xiaoling
  last name: Li
  member of: Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Shenyang, China.

index: 45
item: Zhang Z
  type: Person
  first name: Zhihong
  last name: Zhang
  member of: Anhui Provincial Cancer Hospital, Hefei, China.

index: 46
item: Yang L
  type: Person
  first name: Lei
  last name: Yang
  member of: Gansu Provincial Cancer Hospital, Lanzhou, China.

index: 47
item: Cheng Y
  type: Person
  first name: Ying
  last name: Cheng
  member of: Jilin Cancer Hospital, Changchun, China.

index: 48
item: Chen L
  type: Person
  first name: Likun
  last name: Chen
  member of: Sun Yat-sen University Cancer Center, Guangzhou, China.

index: 49
item: Hou X
  type: Person
  first name: Xue
  last name: Hou
  member of: Sun Yat-sen University Cancer Center, Guangzhou, China.

index: 50
item: Zhang Y
  type: Person
  first name: Yu
  last name: Zhang
  member of: Nanjing Chest Hospital, Nanjing, China.

index: 51
item: Guo J
  type: Person
  first name: Jun
  last name: Guo
  member of: Xingtai People's Hospital, Xingtai, China.

index: 52
item: Wang Z
  type: Person
  first name: Zhen
  last name: Wang
  member of: Linyi Cancer Hospital, Linyi, China.

index: 53
item: Lu H
  type: Person
  first name: Hong
  last name: Lu
  member of: Huaihe Hospital of Henan University, Kaifeng, China.

index: 54
item: Wu D
  type: Person
  first name: Di
  last name: Wu
  member of: Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital (First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University), Shenzhen, China.

index: 55
item: Feng W
  type: Person
  first name: Weineng
  last name: Feng
  member of: The First People's Hospital of Foshan, Foshan, China.

index: 56
item: Li W
  type: Person
  first name: Wen
  last name: Li
  member of: The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.

index: 57
item: Huang J
  type: Person
  first name: Jianan
  last name: Huang
  member of: The First Affiliated Hospital of Soochow University, Suzhou, China.

index: 58
item: Wang Y
  type: Person
  first name: Yan
  last name: Wang
  member of: General Hospital of Ningxia Medical University, Yinchuan, China.

index: 59
item: Song X
  type: Person
  first name: Xia
  last name: Song
  member of: Shanxi Cancer Hospital, Taiyuan, China.

index: 60
item: Peng J
  type: Person
  first name: Jiewen
  last name: Peng
  member of: Zhongshan City People's Hospital, Zhongshan, China.

index: 61
item: Liu L
  type: Person
  first name: Laiyu
  last name: Liu
  member of: Nanfang Hospital Nanfang Medical University, Guangzhou, China.

index: 62
item: Guo Y
  type: Person
  first name: Yubiao
  last name: Guo
  member of: The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

index: 63
item: Li W
  type: Person
  first name: Wenting
  last name: Li
  member of: Akeso Biopharma, Inc, Zhongshan, China.

index: 64
item: Lu D
  type: Person
  first name: Dongmei
  last name: Lu
  member of: Akeso Biopharma, Inc, Zhongshan, China.

index: 65
item: Hu M
  type: Person
  first name: Mingxiu
  last name: Hu
  member of: Akeso Biopharma, Inc, Zhongshan, China.

index: 66
item: Wang ZM
  type: Person
  first name: Zhongmin Maxwell
  last name: Wang
  member of: Akeso Biopharma, Inc, Zhongshan, China.

index: 67
item: Li B
  type: Person
  first name: Baiyong
  last name: Li
  member of: Akeso Biopharma, Inc, Zhongshan, China.

index: 68
item: Xia M
  type: Person
  first name: Michelle
  last name: Xia
  member of: Akeso Biopharma, Inc, Zhongshan, China.

index: 69
item: Zhang L
  type: Person
  first name: Li
  last name: Zhang
  member of: Sun Yat-sen University Cancer Center, Guangzhou, China.

index: 29
item: Wu YL
  type: Person
  first name: Yi-Long
  last name: Wu
  member of: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.Chinese Thoracic Oncology Group, Guangzhou, Guangdong, China.